## FlyBase Best Gene Summary report ## Generated: Sun Oct 06 10:26:08 2024 ## Using datasource: fb_2024_05_reporting ## Note: The single best available gene summary is reported for each D. melanogaster gene. "## Note: Gene summaries are taken from the following sources, in order of decreasing rank:" "## Note: FlyBase gene snapshots, UniProtKB functional descriptions, InteractiveFly summaries, Alliance of Genome Resources automated descriptions, FlyBase automatically generated summaries." "## Note: For other non-D. melanogaster genes, please see FlyBase's ""automated_gene_summaries.tsv.gz"" file." ## #FBgn_ID Summary_Source Summary FBgn0031081 UniProtKB Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle-term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation. (UniProtKB:Q9W5Y0) FBgn0052826 Alliance Predicted to enable CCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031085 Alliance Is expressed in adult head. FBgn0062565 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:Q8IRZ5)" FBgn0041626 FlyBase Gene Snapshot Odorant receptor 19a (Or19a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0031086 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; anterior endoderm anlage; central brain anlage in statu nascendi; foregut anlage in statu nascendi; and head mesoderm anlage. Orthologous to human FOXI3 (forkhead box I3); FOXJ2 (forkhead box J2); and FOXS1 (forkhead box S1)." FBgn0031082 UniProtKB "Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules (PubMed:36342916). Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released (By similarity). Main acetyltransferase responsible for alpha-tubulin 'Lys-40' acetylation in germline cells during the early stages of oogenesis (PubMed:36342916). Required for normal egg chamber separation (PubMed:36342916). (UniProtKB:Q9W5X9)" FBgn0053217 Alliance "Predicted to be involved in rRNA processing. Predicted to be active in nucleus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; germline cell; and visceral muscle cell. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1)." FBgn0052350 FlyBase Gene Snapshot "Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes." FBgn0024733 Alliance A structural constituent of ribosome. Predicted to be involved in ribosomal large subunit assembly. Located in cytosolic ribosome and neuronal cell body. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in autistic disorder; spermatogenic failure 63; and syndromic X-linked mental retardation 35. Orthologous to human RPL10 (ribosomal protein L10) and RPL10L (ribosomal protein L10 like). FBgn0040372 FlyBase Gene Snapshot "G9a (G9a) encodes a histone-lysine methyltransferase involved in epigenetic regulation. It contributes to multiple processes including gene expression, dendrite morphogenesis, larval locomotory behavior as well as short and long-term memory." FBgn0000316 UniProtKB "Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (UniProtKB:P39205)" FBgn0024989 Alliance "Is expressed in several structures, including adult brain; embryonic esophagus; embryonic head epidermis; epithelium; and primary segmental tracheal branch primordium." FBgn0040371 Alliance Is expressed in adult head and spermatozoon. FBgn0029521 FlyBase Gene Snapshot Odorant receptor 1a (Or1a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0004034 FlyBase Gene Snapshot yellow (y) is the founding gene of the Yellow family. Lack of y function results in an abnormal male courtship behavior and a characteristic yellow color of the adult cuticle and larval mouthparts. FBgn0000022 FlyBase Gene Snapshot achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development. FBgn0004170 FlyBase Gene Snapshot "scute (sc) is a proneural gene of the achaete-scute complex. It encodes a transcription factor involved in nervous system development, Notch signalling and sex determination." FBgn0002561 UniProtKB AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. (UniProtKB:P09774) FBgn0000137 FlyBase Gene Snapshot "asense (ase) encodes a transcription factor in the achaete-scute complex. It acts together with other proneural genes in nervous system development, which involves N-mediated lateral inhibition. ase is expressed in the CNS type-I neuroblasts and the PNS sensory organ precursors (SOPs) but not in the proneural clusters that give rise to the SOP via lateral inhibition." FBgn0029522 Alliance Predicted to enable CD27 receptor binding activity. Predicted to be involved in extrinsic apoptotic signaling pathway. Is expressed in organism. FBgn0052817 Alliance "Predicted to enable CD27 receptor binding activity. Predicted to be involved in extrinsic apoptotic signaling pathway. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; lateral cord neurons; and ventral nerve cord primordium." FBgn0029524 Alliance "Predicted to enable CD27 receptor binding activity. Predicted to be involved in extrinsic apoptotic signaling pathway. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; lateral cord neurons; and ventral nerve cord primordium." FBgn0023536 Alliance "Predicted to enable ABC-type oligopeptide transporter activity. Predicted to be involved in oligopeptide export from mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10)." FBgn0023535 FlyBase Gene Snapshot Arginase (Arg) encodes an enzyme that converts arginine into ornithine. Lack of Arg produces a developmental embryonic delay. FBgn0023537 UniProtKB "Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine. (UniProtKB:Q7KW39)" FBgn0029525 Alliance "Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm." FBgn0010019 FlyBase Gene Snapshot Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes. FBgn0011822 FlyBase Gene Snapshot Pepsinogen C-like (Pgcl) encodes a protein predicted to belong to a family of aspartic proteases and controls planar cell polarity. Pgcl mutants result in loss of wing margins. FBgn0040370 Alliance Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be active in plasma membrane. FBgn0040373 Alliance "Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in organism." FBgn0000108 UniProtKB "During development, plays a role in the regulation of the neddylation pathway. Appl and APP-BP1 interact antagonistically during development. (UniProtKB:P14599)" FBgn0025640 Alliance Predicted to enable ribokinase activity. Predicted to be involved in D-ribose metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to human RBKS (ribokinase). FBgn0025635 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in gonad and organism. Orthologous to human HINFP (histone H4 transcription factor)." FBgn0001341 UniProtKB "Has a role in rRNA biogenesis, cell proliferation and tissue growth by contributing to the localization of nclb to the nucleolus. (UniProtKB:Q9W5E4)" FBgn0003575 UniProtKB "RNA-binding protein that suppresses transcription of some RNAs (PubMed:11027289, PubMed:15082769, PubMed:1703632, PubMed:19687295, PubMed:26577379, PubMed:9121479). Together with Wdr82, part of a transcription termination checkpoint that promotes transcription termination of RNAs and their subsequent degradation by the nuclear exosome (PubMed:26577379). Promotes transcription termination of aberrant RNAs, transcripts from genes containing a transposon inserted at their very 5' end or RNAs from heat-shock-inducible repetitive element (PubMed:1703632, PubMed:19687295, PubMed:26577379). Binds RNA preferentially at a sequence that resembles a cryptic 5'-splice site (PubMed:9121479). (UniProtKB:P22293)" FBgn0025634 Alliance Predicted to be involved in chromatin organization. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2B. Orthologous to human GATAD1 (GATA zinc finger domain containing 1). FBgn0025638 FlyBase Gene Snapshot Regulator of cullins 1a (Roc1a) encodes a C2H2 type zinc finger protein and component of several Cullin-Ring E3 ubiquitin ligase complexes. It binds directly to the Cullin subunit within the CRL complex and functions to recruit ubiquitin-charged E2 proteins. FBgn0040383 Alliance "Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21)." FBgn0040382 Alliance Involved in regulation of circadian rhythm. Is expressed in adult head. FBgn0027343 UniProtKB "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. (UniProtKB:O77438)" FBgn0025621 Alliance Is expressed in organism. Orthologous to human HEATR6 (HEAT repeat containing 6). FBgn0015799 FlyBase Gene Snapshot "Retinoblastoma-family protein (Rbf) encodes a protein that binds to members of the E2F transcription factors and forms the DREAM complex, which regulates genes with diverse biological functions including cell cycle regulators, apoptosis regulators, and DNA replication/repair factors. The product of Rbf can also bind chromosomal proteins and modulate genome stability. It is negatively regulated by CycE-Cdk2 and CycD-Cdk4 cyclin-dependent kinase complexes." FBgn0025620 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in dorsal ectoderm anlage; embryonic/larval dorsal vessel; and embryonic/larval midgut. FBgn0015288 FlyBase Gene Snapshot "Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis." FBgn0029531 Alliance Is expressed in embryonic anal pad; embryonic head epidermis; embryonic head sensory system; embryonic labial sensory complex; and larval foregut atrium. FBgn0025639 FlyBase Gene Snapshot "Histone methyltransferase 4-20 (Hmt4-20) encodes a di- and trimethyltransferase, acting on the lysine 20 residue of monomethylated Histone H4." FBgn0002579 UniProtKB Component of the large ribosomal subunit. (UniProtKB:P49630) FBgn0026879 Alliance Is expressed in adult head. Orthologous to human TMA7 (translation machinery associated 7 homolog). FBgn0029529 Alliance Is expressed in adult head and organism. FBgn0025633 Alliance "Involved in several processes, including adult somatic muscle development; notum morphogenesis; and sarcomere organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Teebi hypertelorism syndrome 1 and oblique facial clefting 1. Orthologous to several human genes including SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like)." FBgn0040341 FlyBase Gene Snapshot "CG11664 encodes a protein with homology to serine-type endopeptidases, but is not predicted to have catalytic activity due to mutations in its active site. It is produced by the male accessory glands." FBgn0040339 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (UniProtKB:Q9V439)" FBgn0040340 Alliance "Predicted to be involved in protein insertion into ER membrane. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa primordium; dorsal epidermis primordium; and epithelium. Orthologous to several human genes including TRAM1 (translocation associated membrane protein 1) and TRAM1L1 (translocation associated membrane protein 1 like 1)." FBgn0040347 FlyBase Gene Snapshot mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. FBgn0042146 Alliance Predicted to enable RNA binding activity. FBgn0040337 UniProtKB "Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. (UniProtKB:Q9W5B6)" FBgn0040398 Alliance Is expressed in adult head; amnioserosa; embryonic/larval hemocyte; visceral mesoderm derivative; and yolk nucleus. FBgn0040365 Alliance Predicted to enable mRNA binding activity. FBgn0040397 Alliance Predicted to enable UDP-galactosyltransferase activity. Predicted to be involved in N-glycan processing and glycosylation. Predicted to be active in cytoplasm. Is expressed in organism. FBgn0026143 FlyBase Gene Snapshot Cell division cycle 45 (Cdc45) encodes a protein that contributes to 3'-5' DNA helicase activity of the Cdc45/Mcm2-7/GINS complex. It is involved in chromosome condensation and the regulation of the mitotic G1/S transition. FBgn0040351 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. FBgn0040338 UniProtKB TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity). (UniProtKB:Q9W5B9) FBgn0040350 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human SVOPL (SVOP like). FBgn0040349 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Is expressed in Malpighian tubule primordium; adult head; adult heart; epithelium; and gut section. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). FBgn0040348 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in intracellular protein transport. Is expressed in embryonic brain; embryonic head sensory system; and larval ventral nerve cord. Orthologous to human RUNDC1 (RUN domain containing 1). FBgn0040346 Alliance Predicted to enable GTPase activity. Is expressed in organism. Orthologous to human GPN1 (GPN-loop GTPase 1). FBgn0040342 Alliance Is expressed in adult head. FBgn0040345 Alliance Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be part of chromatin. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human NAP1L3 (nucleosome assembly protein 1 like 3) and NAP1L5 (nucleosome assembly protein 1 like 5). FBgn0052814 Alliance Involved in germ cell development. Located in cytosol. FBgn0040364 Alliance Is expressed in adult head; centripetal follicle cell; egg chamber; embryonic/larval midgut; and embryonic/larval midgut primordium. FBgn0040360 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic epipharynx; and gut section." FBgn0040359 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval posterior spiracle; gonad; and inclusive hindgut primordium." FBgn0029568 Alliance Located in egg chorion. FBgn0040367 Alliance Is expressed in adult head. FBgn0025642 Alliance Predicted to enable calcium ion binding activity. Predicted to be active in plasma membrane. FBgn0004650 FlyBase Gene Snapshot "female sterile (1) Nasrat (fs(1)N) encodes encodes a protein that is required, along with the products of fs(1)M3 and clos, for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation." FBgn0024362 UniProtKB Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. (UniProtKB:Q95RC0) FBgn0024361 UniProtKB "Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium. (UniProtKB:O46101)" FBgn0024364 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human ESF1 (ESF1 nucleolar pre-rRNA processing protein homolog)." FBgn0024987 Alliance Enables RNA binding activity. Involved in defense response to bacterium; post-transcriptional gene silencing; and regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in organism. FBgn0023169 FlyBase Gene Snapshot "AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited." FBgn0052813 Alliance "Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle cell; and visceral mesoderm derivative. Orthologous to human MSANTD3 (Myb/SANT DNA binding domain containing 3)." FBgn0024985 UniProtKB May have a role in lysosome distribution by interacting with Arl8. (UniProtKB:O76878) FBgn0027794 FlyBase Gene Snapshot Leucine-rich pentatricopeptide repeat containing 2 (Lrpprc2) encodes an RNA-binding protein that forms a complex with the product of SLIRP2. It localizes to the mitochondrial matrix where it functions to coordinate mitochondrial translation. FBgn0024986 Alliance "Predicted to be involved in cell redox homeostasis. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm." FBgn0000826 FlyBase Gene Snapshot "pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu." FBgn0024365 Alliance "Predicted to enable amino acid transmembrane transporter activity and potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Is expressed in several structures, including adult midgut; anterior-posterior subdivision of organism; embryonic/larval central nervous system; embryonic/larval gut; and mesoderm. Orthologous to human SLC12A8 (solute carrier family 12 member 8)." FBgn0024360 UniProtKB Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation. (UniProtKB:O46102) FBgn0024366 Alliance "Is expressed in several structures, including adult fat body; antennal anlage; central brain anlage; dorsal ectoderm; and dorsal head epidermis anlage." FBgn0025641 FlyBase Gene Snapshot "Dishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons." FBgn0028550 FlyBase Gene Snapshot "Activating transcription factor 3 (Atf3) encodes a transcription factor whose levels are tightly controlled during development. It forms homodimers or heterodimerizes with the product of Jra. It contributes to abdominal morphogenesis, and immune system and metabolic homeostasis." FBgn0026876 Alliance Predicted to enable DNA helicase activity. Predicted to be involved in DNA duplex unwinding and establishment of sister chromatid cohesion. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). FBgn0040366 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Predicted to be active in nucleus. Is expressed in organism." FBgn0040363 Alliance Predicted to enable UDP-galactosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be active in cytoplasm. FBgn0040368 FlyBase Gene Snapshot eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation. FBgn0026872 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). FBgn0029580 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in adult head. FBgn0025383 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0025381 FlyBase Gene Snapshot rush hour (rush) encodes an endosome-associated protein that directly binds phosphatidylinositol 3-phosphate (PI3P) and the Rab GDP dissociation inhibitor encoded by Gdi. rush product regulates endosomal trafficking by modulating the activity of Rab proteins. FBgn0025394 FlyBase Gene Snapshot insomniac (inc) encodes a BTB domain-containing protein that is essential in neurons for normal sleep-wake cycles. FBgn0000482 UniProtKB "Core component of the class C core vacuole/endosome tethering (CORVET) and the homotypic fusion and vacuole protein sorting (HOPS) tethering complexes involved in endo-lysosomal vesicle trafficking and lysosome biogenesis (PubMed:10549280, PubMed:24554766, PubMed:25422373, PubMed:27253064, PubMed:28063257, PubMed:31194677, PubMed:9065698). The CORVET complex facilitates docking and fusion of endosomal vesicles during endosome maturation, acts upstream of HOPS, but is not involved in autophagic flux (PubMed:10549280, PubMed:25422373, PubMed:27253064, PubMed:31194677). The CORVET complex may cooperate with the early endosomal tether Rbsn-5 to mediate endosomal fusion (PubMed:27253064). The HOPS complex facilitates docking and fusion of lysosomes with late endosomes and several other types of vesicles (PubMed:24554766, PubMed:28063257, PubMed:31194677). The HOPS complex is also involved in autophagy and crinophagy (the elimination of unused secretory granules through their fusion with lysosomes) (PubMed:24554766, PubMed:31194677). The HOPS complex mediates autophagocitic flux, probably by binding autophagosome-associated Syx17/syntaxin 17, promoting assembly of the trans-SNARE complex and instigating autophagosome-lysosome fusion (PubMed:24554766, PubMed:28063257). Independent of Syx17/syntaxin 17, HOPS is involved in biosynthetic transport to lysosomes and lysosome-related organelles such as eye-pigment granules (PubMed:10549280, PubMed:24554766, PubMed:31194677). Required for endocytic degradation of boss/bride of sevenless and N/Notch in developing ommatidia (PubMed:24554766). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257). In larval neuromuscular junctions, essential for endosomal sorting that traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route (PubMed:25422373). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599). (UniProtKB:Q24314)" FBgn0001189 UniProtKB Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes. (UniProtKB:Q9W568) FBgn0024897 Alliance Predicted to be located in glutamatergic synapse. Is expressed in adult fat body. Orthologous to human NPTX2 (neuronal pentraxin 2). FBgn0025391 FlyBase Gene Snapshot Sarcoglycan delta (Scgdelta) encodes a transmembrane protein that is required for normal muscle structure and function. It contributes to sarcomere organization and heart contraction. FBgn0025378 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLK10 (kallikrein related peptidase 10). FBgn0023130 Alliance Involved in embryonic development via the syncytial blastoderm. Is expressed in embryonic/larval midgut; embryonic/larval muscle system; and organism. FBgn0023530 Alliance Involved in neuromuscular process. Is expressed in adult abdomen; adult head; adult thorax; and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 43 and neurodegeneration with brain iron accumulation 4. Orthologous to human C19orf12 (chromosome 19 open reading frame 12). FBgn0025390 Alliance Predicted to be an extracellular matrix structural constituent. Located in egg chorion. Is expressed in embryonic/larval gut; embryonic/larval salivary gland; and organism. FBgn0003517 UniProtKB Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development. (UniProtKB:P38979) FBgn0044508 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0025382 FlyBase Gene Snapshot Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. FBgn0052808 Alliance "Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in several diseases, including Lewy body dementia; artery disease (multiple); chronic kidney disease (multiple); demyelinating disease; and synucleinopathy (multiple). Orthologous to several human genes including KLK14 (kallikrein related peptidase 14) and KLK3 (kallikrein related peptidase 3)." FBgn0027791 UniProtKB "Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. (UniProtKB:Q9W589)" FBgn0027793 Alliance Is expressed in adult heart; embryonic Malpighian tubule; and embryonic main segment of Malpighian tubule. FBgn0026873 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (UniProtKB:Q9XZT1)" FBgn0023513 UniProtKB Involved in recombination-dependent repair of stalled or collapsed replication forks. (UniProtKB:O46089) FBgn0014411 UniProtKB "Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis. (UniProtKB:Q9W552)" FBgn0023514 Alliance "Predicted to be involved in DNA-templated DNA replication and rRNA processing. Predicted to be part of nuclear pre-replicative complex and rixosome complex. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human WDR18 (WD repeat domain 18)." FBgn0029594 UniProtKB "May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain. (Microbial infection) Required for optimal replication of E.chaffeensis. (UniProtKB:Q9W549)" FBgn0023519 Alliance "Predicted to enable rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval muscle system; embryonic/larval visceral muscle cell; and spermatozoon. Orthologous to human MRPL16 (mitochondrial ribosomal protein L16)." FBgn0023509 FlyBase Gene Snapshot "Myb-interacting protein 130 (mip130) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle." FBgn0023510 FlyBase Gene Snapshot "Rabconnectin-3B (Rbcn-3B) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells." FBgn0023508 FlyBase Gene Snapshot "Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis." FBgn0023522 UniProtKB N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. (UniProtKB:Q9I7X6) FBgn0023521 Alliance Predicted to be involved in tRNA wobble uridine modification. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human KTI12 (KTI12 chromatin associated homolog). FBgn0025627 Alliance "Is expressed in several structures, including clypeo-labral primordium; dorsal ectoderm; dorsal epidermis primordium; embryonic/larval midgut primordium; and gut section." FBgn0025630 UniProtKB "Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (By similarity). Function plays an important role in a RNA repair and splicing pathway which controls axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:25961792, PubMed:31919191). In response to axotomy, negatively regulates splicing of Xbp1 which in turn activates downstream effectors which inhibit axon regeneration, including down-regulating the microtubule regulators ringer and futsch (PubMed:25961792, PubMed:31919191). (UniProtKB:O77264)" FBgn0025629 UniProtKB Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (UniProtKB:O77263) FBgn0025626 Alliance "Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval salivary gland; foregut primordium; and salivary gland body primordium." FBgn0025625 FlyBase Gene Snapshot Salt-inducible kinase 2 (Sik2) encodes a serine/threonine kinase that is activated by the product of Lkb1. It regulates lipid storage and energy homeostasis by controlling the activity of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). FBgn0025631 UniProtKB "Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord. (UniProtKB:Q9W534)" FBgn0026878 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of antibacterial peptide biosynthetic process. FBgn0000667 FlyBase Gene Snapshot "alpha actinin (Actn) encodes an actin cross-linking protein with muscle and non-muscle specific isoforms, which are produced by alternative spicing. The muscle isoform has a role in muscle development while the non-muscle isoform localizes to ovarian ring canals and has a role in cytoskeletal remodeling of follicle cells." FBgn0003964 UniProtKB Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene. (UniProtKB:P20153) FBgn0023545 UniProtKB "Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). (UniProtKB:Q8T4E1)" FBgn0023520 UniProtKB Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity). (UniProtKB:O46080) FBgn0023512 FlyBase Gene Snapshot eukaryotic translation initiation factor 2B subunit epsilon (eIF2Bepsilon) encodes a guanyl-nucleotide exchange factor. FBgn0023511 FlyBase Gene Snapshot "ER degradation enhancer, mannosidase alpha-like 1 (Edem1) encodes a lectin in the endoplasmic reticulum (ER) lumen that helps to recognize specific misfolded glycoproteins in this cellular compartment for retro-translation to the cytoplasm and ubiquitin-mediated degradation. This process is referred to as ""ER-Associated Degradation""." FBgn0052801 Alliance Is expressed in adult fat body. FBgn0023518 FlyBase Gene Snapshot trithorax-related (trr) encodes a methyltransferase that trimethylates lysine 4 of the histone encoded by His3. The activity of the product of trr is stimulated by ecdysone and is important for eye development. FBgn0026088 Alliance Orthologous to human BBLN (bublin coiled coil protein). FBgn0026089 Alliance Predicted to be a structural constituent of ribosome. Predicted to be active in mitochondrial ribosome. Is expressed in adult head. Orthologous to human MRPL57 (mitochondrial ribosomal protein L57). FBgn0023517 UniProtKB "Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity. (UniProtKB:O46084)" FBgn0023516 Alliance Predicted to enable peroxisome matrix targeting signal-1 binding activity. Involved in protein import into peroxisome matrix and response to anesthetic. Located in cytosol and peroxisome. Is expressed in embryonic cortex and yolk. Used to study peroxisomal biogenesis disorder and peroxisome biogenesis disorder 2A. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to several human genes including PEX5 (peroxisomal biogenesis factor 5). FBgn0023515 UniProtKB "May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:31839537). Limits replication stress and DNA double-strand breaks (PubMed:31839537). (UniProtKB:Q7KW09)" FBgn0028969 FlyBase Gene Snapshot Coat Protein (coatomer) delta (deltaCOP) mutants show narrow tracheal tubes due to defective luminal extracellular matrix secretion. FBgn0026090 Alliance "Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of Ragulator complex. Predicted to be active in lysosome. Is expressed in adult head. Orthologous to human LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)." FBgn0025624 Alliance Predicted to be involved in regulation of autophagy. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1) and DRAM2 (DNA damage regulated autophagy modulator 2). FBgn0040395 FlyBase Gene Snapshot Unc-76 (Unc-76) encodes a kinesin binding protein involved in axo-dendritic transport. FBgn0000382 FlyBase Gene Snapshot "corkscrew (csw) encodes a non receptor tyrosine phosphatase acting downstream of receptor tyrosine kinases (RTKs) such as Egfr, tor and FGF RTKs. The product of csw contributes to growth regulation, cell survival and developmental patterning." FBgn0023507 FlyBase Gene Snapshot D-2-hydroxyglutaric acid dehydrogenase (D2hgdh) encodes an enzyme involved in oxidation-reduction metabolism. FBgn0004654 FlyBase Gene Snapshot "Phosphogluconate dehydrogenase (Pgd) encodes a cytosolic enzyme that catalyzes the oxidation of 6-phospho-D-gluconate to D-ribulose 5-phosphate, with the concomitant reduction of NADP+ to NADPH in the oxidative branch of the pentose phosphate pathway." FBgn0023540 Alliance "Predicted to enable actin binding activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in actin cytoskeleton. Is expressed in several structures, including adult head; embryonic central brain; embryonic foregut; embryonic foregut sensory structure; and embryonic hypopharynx. Orthologous to human ABRA (actin binding Rho activating protein)." FBgn0025839 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Orthologous to human NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7)." FBgn0011576 UniProtKB Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q27589) FBgn0015036 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:O46054) FBgn0003116 FlyBase Gene Snapshot prune (pn) encodes a phosphoesterase that localizes to the mitochondrial matrix. It hydrolyzes cAMP and negatively regulates mitochondrial cAMP signaling. It is involved in mtDNA maintenance and eye pigment biosynthesis. FBgn0040899 Alliance "Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section." FBgn0024984 Alliance Predicted to be involved in anaphase-promoting complex-dependent catabolic process. Predicted to be part of anaphase-promoting complex. Is expressed in organism. FBgn0023549 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14). FBgn0003048 UniProtKB Involved in neurogenesis. (UniProtKB:P18490) FBgn0000810 FlyBase Gene Snapshot "female sterile (1) K10 (fs(1)K10) encodes a nuclear protein of unknown biochemical function required during oogenesis for the proper localization of grk mRNA and protein in the oocyte, a key step in the specification of the dorsoventral axis of the oocyte, mature egg, and future embryo." FBgn0023523 FlyBase Gene Snapshot Odorant receptor 2a (Or2a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0023527 Alliance "Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Predicted to be part of t-UTP complex. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human UTP15 (UTP15 small subunit processome component)." FBgn0040391 Alliance "Predicted to be active in mitochondrion. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial)." FBgn0003079 FlyBase Gene Snapshot "Raf oncogene (Raf) encodes a serine-threonine protein kinase that acts downstream of the product of Ras85D. It activates the MEK/ERK pathway to regulate cell proliferation, differentiation and survival downstream of receptor tyrosine kinases such as those encoded by tor, Egfr, and sev." FBgn0003159 Alliance "Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm." FBgn0040389 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; embryonic/larval muscle system; and gut section. Orthologous to human MRPL14 (mitochondrial ribosomal protein L14)." FBgn0044047 FlyBase Gene Snapshot Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. FBgn0040392 Alliance Predicted to enable DNA binding activity. FBgn0023526 Alliance "Is expressed in several structures, including anterior endoderm anlage; central brain primordium; embryonic central brain neurons; ganglia; and head mesoderm anlage." FBgn0023529 Alliance "Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in cellular response to hypoxia. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; dorsal ectoderm; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1)." FBgn0023528 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). FBgn0027296 FlyBase Gene Snapshot tempura (temp) encodes a protein-prenyltransferase subunit that regulates Notch signaling. FBgn0023524 Alliance Predicted to enable potassium channel regulator activity. Predicted to be involved in regulation of muscle contraction and regulation of potassium ion transport. Predicted to be active in plasma membrane and striated muscle dense body. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and ventral nerve cord primordium. FBgn0023525 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; embryonic head sensory system; and labral sensory complex. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0000377 FlyBase Gene Snapshot "crooked neck (crn) encodes a component of the splicing complex involved in axon ensheathment, glial cell migration and Malpighian tubule morphogenesis." FBgn0001330 Alliance "Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in ovary. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37)." FBgn0004397 FlyBase Gene Snapshot "Vinculin (Vinc) encodes a key mechanoeffector of cell-cell and cell-extracellular matrix adhesion. It binds to the products of rhea and alpha-Cat, when they are stretched by force, and links them to actin. Vinc mutant flies are viable and fertile although mild defects have been documented in muscle attachment and heart function." FBgn0023550 FlyBase Gene Snapshot Fatty acyl-CoA reductase in oenocytes (FarO) encodes a long-chain-fatty-acyl-CoA reductase involved in the regulation of cell growth and lipid storage. FBgn0023542 Alliance "Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosomal large subunit export from nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; and gut section. Orthologous to human NMD3 (NMD3 ribosome export adaptor)." FBgn0023541 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:O46051) FBgn0005670 UniProtKB Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:P33269) FBgn0004655 FlyBase Gene Snapshot wings apart-like (wapl) encodes a protein that interacts with the product of pds5 to form the releasin complex that enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. It also influences gene activation and silencing through interactions with cohesin. FBgn0013432 Alliance Involved in iron-sulfur cluster assembly. Located in mitochondrion. Part of L-cysteine desulfurase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). FBgn0004861 FlyBase Gene Snapshot "polyhomeotic proximal (ph-p) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-d, ph-p functions as a tumor suppressor gene." FBgn0004860 FlyBase Gene Snapshot "polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene." FBgn0040394 Alliance Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including CCNL1 (cyclin L1). FBgn0040376 Alliance Predicted to enable aralkylamine N-acetyltransferase activity. Is expressed in adult head. FBgn0040066 UniProtKB "Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:25310983). In neurons and together with DNA N6-methyl adenine demethylase Tet, plays a role in the maintenance of transcriptional activation for specific sets of genes (PubMed:30078725). (UniProtKB:Q9V3J8)" FBgn0001404 UniProtKB Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system. (UniProtKB:O01346) FBgn0040336 FlyBase Gene Snapshot Seipin (Seipin) encodes a transmembrane protein with roles in ER calcium homeostasis and lipid storage. FBgn0040333 Alliance "Predicted to enable calcium channel activity. Involved in response to cold. Predicted to be active in membrane. Orthologous to human PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting)." FBgn0040334 FlyBase Gene Snapshot "Tetraspanin 3A (Tsp3A) encodes a member of the tetraspanin superfamily. With two other tetraspanins, encoded by Tsp26A and Tsp86D, it regulates the trafficking of the product of kuz and consequently Notch signaling and several Notch-dependent developmental processes." FBgn0029629 UniProtKB "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (UniProtKB:Q9W4X7)" FBgn0011566 Alliance Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be active in nucleus. Orthologous to several human genes including SMYD3 (SET and MYND domain containing 3). FBgn0011606 FlyBase Gene Snapshot Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis. FBgn0040375 Alliance Orthologous to human GUCD1 (guanylyl cyclase domain containing 1). FBgn0040377 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). (UniProtKB:Q9NEF6)" FBgn0040388 FlyBase Gene Snapshot "brother of ihog (boi) encodes a transmembrane protein that binds to the product of hh. The products of boi and ihog promote Hh signaling in receiving cells by acting as a co-receptor for the effector protein encoded by ptc. The product of boi also can suppress Hh signaling through a sequestration and release mechanism in cells producing the product of hh. It regulates many hh-dependent processes including proliferation, cell fate specification, and patterning." FBgn0003714 FlyBase Gene Snapshot technical knockout (tko) encodes the mitochondrial ribosomal protein S12. It is involved in the response to hypoxia and mechanosensory and courtship behaviors. FBgn0001150 FlyBase Gene Snapshot "giant (gt) encodes a transcription factor in the basic leucine zipper family. It is one of the ""gap"" transcription factors, transcribed very early in embryonic development, that help to divide the embryo along the anteroposterior axis." FBgn0052797 Alliance Predicted to be active in nucleus. FBgn0003371 FlyBase Gene Snapshot "shaggy (sgg) encodes a glycogen synthase kinase 3, and a key component of the beta-catenin destruction complex. It functions in the canonical Wnt cascade." FBgn0003068 UniProtKB "Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361). (UniProtKB:P07663)" FBgn0024993 Alliance "Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Is expressed in several structures, including antennal primordium; anterior endoderm; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Orthologous to human SAMD1 (sterile alpha motif domain containing 1) and SAMD13 (sterile alpha motif domain containing 13)." FBgn0024996 Alliance Predicted to enable translation initiation factor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in cellular response to hypoxia. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). FBgn0024997 Alliance Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. FBgn0024991 Alliance Predicted to be active in nucleus. Is expressed in germline cell; organism; and primordial germ cell. FBgn0000928 FlyBase Gene Snapshot female sterile (1) Yb (fs(1)Yb) encodes a protein involved in maintenance of the germ-line stem cell population during oogenesis. FBgn0000927 FlyBase Gene Snapshot "female sterile (1) Young arrest (fs(1)Ya) encodes a maternally-expressed protein that is required for mitotic phase initiation during early embryogenesis. It localizes in the nuclear lamina of the embryo, and binds DNA and the product of His2B. In developing oocytes the product of fs(1)Ya is cytoplasmic, but enters nuclei when it is dephosphorylated during egg activation." FBgn0000520 FlyBase Gene Snapshot "deformed wings (dwg) encodes an architectural chromatin protein essential for embryonic development that organizes open chromatin in regulatory regions (predominantly promoters). dwg product binding site was found in the insulator encoded by scs, and its functions include enhancer blocking, support of distant interactions and recruitment of transcription factors." FBgn0024975 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to several human genes including ZFP37 (ZFP37 zinc finger protein); ZFP90 (ZFP90 zinc finger protein); and ZNF559-ZNF177 (ZNF559-ZNF177 readthrough)." FBgn0040356 Alliance Predicted to enable DNA binding activity. Is expressed in spermatocyte. FBgn0003996 FlyBase Gene Snapshot "white (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker." FBgn0040384 Alliance Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human TMEM120A (transmembrane protein 120A) and TMEM120B (transmembrane protein 120B). FBgn0024980 FlyBase Gene Snapshot "Syntaxin 4 (Syx4) encodes a member of the superfamily of SNARE genes, which mediate membrane fusion. The product of Syx4 is associated with Golgi to plasma membrane transport as well as acting as a plasma membrane t-SNARE to regulate synaptic growth at the neuromuscular junction." FBgn0000376 UniProtKB "Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV). (UniProtKB:O76906)" FBgn0024973 Alliance Predicted to enable ubiquitin binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is expressed in organism. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). FBgn0024998 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Orthologous to human WBP11 (WW domain binding protein 11)." FBgn0024995 Alliance Enables phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in organism and ring gland. FBgn0024994 FlyBase Gene Snapshot "UDP-galactose transporter (Ugalt) encodes a transporter involved in UDP-N-acetylgalactosamine, UDP-galactose and galactose transmembrane transport." FBgn0024992 Alliance "Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing and regulation of mitochondrial membrane permeability. Located in mitochondrion. Part of m-AAA complex. Is expressed in adult head and spermatozoon. Used to study hereditary spastic paraplegia 7. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)." FBgn0000092 UniProtKB "Component of the circadian clock or downstream effector of clock function (PubMed:2517256, PubMed:31080079). Required for suppressing daytime sleep (siesta) under ambient environmental temperatures. Part of a heat avoidance mechanism that modulates daytime sleep behavior under different environmental temperatures to minimize the risk of heat exposure. Under cooler ambient temperatures, suppresses daytime sleep (siesta) and thus allows for longer periods of daytime activity (PubMed:31080079). (UniProtKB:O76879)" FBgn0025838 Alliance Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. FBgn0011276 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic brain; larval ventral midline neurons; midline primordium; and ventral midline of embryo. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; and adult T-cell leukemia/lymphoma. Orthologous to several human genes including TAL2 (TAL bHLH transcription factor 2)." FBgn0004647 UniProtKB "Essential signaling protein which has a major role in many developmental processes (PubMed:3935325). Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination (PubMed:10935637, PubMed:12909620, PubMed:15620650, PubMed:18243100). Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex (PubMed:7671825). Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction (PubMed:11719214, PubMed:12369105, PubMed:3935325). Regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt; might also regulate dpn expression through the activation of the transcriptional regulator Su(H) (PubMed:18342578, PubMed:20152183, PubMed:21262215, PubMed:23056424, PubMed:27151950, PubMed:28899667). Targeted for ESCRT-mediated endosomal sequestration and lysosomal degradation by various E3 ubiquitin ligases to regulate the Notch signaling pathway (PubMed:17084358, PubMed:22162134, PubMed:33349255). Can undergo ligand-dependent and non-canonical ligand-independent activation (PubMed:22162134). Ligand-independent activation is dependent on endosome acidification and probably occurs in late endosomes or lysosome (PubMed:23178945). Ectopic ligand-independent activation occurs when disruption of the endolysosomal pathway, particularly of the ESCRT-III complex, prevents sequestration of the receptor in intraluminal vesicles of multivesicular bodies (PubMed:17084357, PubMed:17084358, PubMed:17088062, PubMed:23178945). (UniProtKB:P07207)" FBgn0040396 Alliance Predicted to enable protein-disulfide reductase (NAD(P)H) activity. Predicted to be active in cytosol. Is expressed in embryonic midgut chamber; embryonic small intestine; embryonic/larval midgut; organism; and spermatozoon. Orthologous to human TXNDC17 (thioredoxin domain containing 17). FBgn0000479 FlyBase Gene Snapshot "Phosphodiesterase 4 (Pde4) encodes a cAMP-specific phosphodiesterase, responsible for cAMP degradation. Pde4 product plays a pivotal role in neurological and behavioral plasticity including synaptic development and function, learning and courtship. The product of Pde4 is also known to affect regulation of several developmental processes such as oogenesis." FBgn0003374 Alliance Involved in puparial adhesion. Located in adhesive extracellular matrix. Is expressed in embryonic/larval salivary gland; organism; and salivary gland. FBgn0029660 Alliance Is expressed in spermatozoon. FBgn0029662 Alliance "Predicted to be involved in sensory perception of sound. Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; embryonic/larval posterior spiracle; epithelium; and larval foregut atrium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1)." FBgn0029661 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein polyubiquitination and regulation of mitochondrial fission. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). FBgn0029659 Alliance Is expressed in adult head. FBgn0052493 Alliance Predicted to enable CAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003086 Alliance Is expressed in embryonic/larval salivary gland and organism. FBgn0010296 Alliance Is expressed in organism. FBgn0010295 Alliance Is expressed in embryonic/larval salivary gland. FBgn0000644 Alliance Is expressed in follicle cell. FBgn0028746 Alliance Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human C18orf32 (chromosome 18 open reading frame 32). FBgn0040355 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in synaptic signaling. Predicted to be active in plasma membrane. FBgn0029642 Alliance Predicted to enable heme binding activity and transmembrane ascorbate ferrireductase activity. FBgn0029648 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Is expressed in adult head; adult heart; and organism. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). FBgn0028369 FlyBase Gene Snapshot "kin of irre (kirre) encodes a transmembrane protein of the Ig superfamily that is involved in heterotypic interactions with the product of sns. Interactions with intracellular adaptors regulate cytoskeleton dynamics. Its biological roles include myoblast aggregation and fusion, nephrocyte diaphragm formation, and cell sorting in the eye and wing imaginal discs." FBgn0003285 FlyBase Gene Snapshot roughest (rst) encodes a multi-purpose transmembrane protein that is well studied in the fly eye and muscle during development. It interacts with the transmembrane ligand encoded by hbs to guide cell movement. FBgn0029639 Alliance Is expressed in embryonic anal pad; embryonic dorsal epidermis; embryonic hindgut; embryonic large intestine; and embryonic ventral epidermis. FBgn0029664 Alliance Predicted to enable Ser-tRNA(Ala) hydrolase activity. Predicted to be involved in regulation of translational fidelity. Is expressed in adult head and organism. Orthologous to human PTGES3L-AARSD1 (PTGES3L-AARSD1 readthrough) and AARSD1 (alanyl-tRNA synthetase domain containing 1). FBgn0029666 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. Orthologous to human RO60 (Ro60, Y RNA binding protein)." FBgn0052792 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult fat body. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). FBgn0044046 FlyBase Gene Snapshot "Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth." FBgn0023215 FlyBase Gene Snapshot "Mnt (Mnt) encodes a protein that belongs to the basic-helic-loop-helix-zipper class of transcription factors, which form heterodimers with the protein encoded by Max. Mnt product acts as a repressor of transcription by recruiting a co-repressor complex to its genomic binding sites. It antagonizes cell growth promoting functions of the product encoded by Myc and its depletion produces flies with larger cells, increased weight, and decreased lifespan." FBgn0015286 FlyBase Gene Snapshot "Ras-like protein A (Rala) encodes a GTPase that regulates Notch, Jak/Stat and JNK signalling pathways." FBgn0023216 FlyBase Gene Snapshot "Poly(ADP-ribose) glycohydrolase (Parg) encodes a nuclear enzyme that degrades poly(ADP-ribose) to mono(ADP-ribose) from the acceptor proteins after their modification by the product of Parp1. It performs several vital roles, including regulation of developmental patterning and germ-line stem cell fate." FBgn0029672 Alliance "Predicted to be involved in ribosome biogenesis. Predicted to be part of Noc4p-Nop14p complex and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval visceral muscle cell; and visceral muscle primordium. Orthologous to human NOC4L (nucleolar complex associated 4 homolog)." FBgn0052791 Alliance Involved in synapse organization. Located in neuron projection membrane. Is expressed in ganglia; larval ventral midline glial cell; medulla; optic lobe intrinsic neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). FBgn0029667 UniProtKB Cytoskeletal linker which probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). (UniProtKB:Q8MT08) FBgn0029665 Alliance "Predicted to enable protein transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human TIMM29 (translocase of inner mitochondrial membrane 29)." FBgn0029663 Alliance Predicted to enable neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid transport; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in anterior-posterior subdivision of organism; embryonic head sensory system; embryonic/larval nervous system; and ganglia. Human ortholog(s) of this gene implicated in Hartnup disease and autosomal recessive intellectual developmental disorder 48. Orthologous to several human genes including SLC6A15 (solute carrier family 6 member 15); SLC6A17 (solute carrier family 6 member 17); and SLC6A18 (solute carrier family 6 member 18). FBgn0052785 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0025118 Alliance Predicted to enable CCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0028491 Alliance Predicted to enable dipeptide transmembrane transporter activity. Predicted to be involved in dipeptide import across plasma membrane. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in adult head. Orthologous to several human genes including SLC15A1 (solute carrier family 15 member 1). FBgn0029681 Alliance Is expressed in embryonic dorsal epidermis; embryonic esophagus; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval salivary gland. FBgn0029686 FlyBase Gene Snapshot "Gaulos (Glos) encodes a protein that is required for neuromuscular function and adult viability, and is part of the Survival Motor Neuron (SMN) complex." FBgn0052786 Alliance Part of SMN complex. FBgn0052783 Alliance Part of SMN complex. FBgn0029687 FlyBase Gene Snapshot "VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections." FBgn0029690 Alliance Predicted to enable carboxylesterase activity. Orthologous to human CES3 (carboxylesterase 3) and CES4A (carboxylesterase 4A). FBgn0029689 Alliance Predicted to enable asparaginase activity. Predicted to be involved in amino acid metabolic process. Is expressed in organism. Orthologous to human ASPG (asparaginase). FBgn0029688 FlyBase Gene Snapshot "lava lamp (lva) encodes a microfilament/microtubule-associated protein involved in cellularization, Golgi localization, and dendrite morphogenesis." FBgn0029685 Alliance Predicted to enable N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in Golgi membrane. Is expressed in adult head and organism. Orthologous to human CASD1 (CAS1 domain containing 1). FBgn0019661 Interactive Fly "X chomosome associated RNA - chromatin associated non-translated RNA involved in dosage compensation - ectopically expressed roX1 and roX2 RNAs target high-affinity sites on the X chromosome in trans and, via spatial proximity, induce spreading of the MSL complex in cis, leading to increased expression of neighboring autosomal genes - The MSL complex regulates nucleosome positioning at high-affinity sites, therefore acting locally rather than influencing the overall chromosomal architecture." FBgn0000221 UniProtKB Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal-ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation. (UniProtKB:Q24157) FBgn0026084 FlyBase Gene Snapshot ciboulot (cib) encodes an actin binding protein involved in brain development and the remodeling of the larval central nervous system. FBgn0026085 UniProtKB "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). (UniProtKB:Q9W4M8)" FBgn0026083 FlyBase Gene Snapshot twenty-four (tyf) encodes a protein that forms a complex together with the products of Atx2 and Lsm12. This complex binds per mRNA and activates its translation to sustain circadian rhythms. The tyf product is also involved in immune defense against Listeria monocytogenes infection. FBgn0066114 UniProtKB "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates. (UniProtKB:O97422)" FBgn0029697 Alliance Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Located in egg chorion. FBgn0029706 Alliance Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be part of mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex and pyruvate dehydrogenase complex. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). FBgn0040907 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MRPL33 (mitochondrial ribosomal protein L33). FBgn0002707 FlyBase Gene Snapshot meiotic 9 (mei-9) encodes the catalytic subunit of the Mei-9-Ercc1 structure-selective endonuclease that functions in nucleotide excision repair. The products of mei-9 and Ercc1 interact with the product of mus312 to generate meiotic crossovers. FBgn0052774 Alliance Predicted to be an extracellular matrix structural constituent. Involved in egg chorion assembly. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval salivary gland and organism. FBgn0041252 Alliance Involved in egg chorion assembly. Located in cytoplasm. FBgn0029696 Alliance Involved in egg chorion assembly. FBgn0000635 FlyBase Gene Snapshot "Fasciclin 2 (Fas2) encodes a member of the immunoglobulin superfamily of cell adhesion molecules, and functions during axon extension and imaginal disc growth. Fas2 promotes EGFR-dependent epithelial cell proliferation in imaginal discs at low and moderate expression levels, whereas it acts as an EGFR repressor at high expression levels." FBgn0026080 FlyBase Gene Snapshot "Tat interactive protein 60kDa (Tip60) encodes a lysine acetyltransferase that acetylates histone proteins to regulate chromatin packaging and epigenetic gene control. It also acetylates non-histone proteins, and plays a role in apoptosis, DNA repair and various neural processes." FBgn0026079 UniProtKB RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory. (UniProtKB:Q9W4M9) FBgn0004832 UniProtKB "Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). (UniProtKB:P28518)" FBgn0029693 UniProtKB "S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs (PubMed:32504809). Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1) (PubMed:32504809). Positively regulates the Ago2-dependent small RNA pathway, with roles in both siRNA biogenesis and RISC assembly (PubMed:32504809). Involved in facilitating conversion of pre-RISC into holo-RISC, possibly by promoting the unwinding of Ago2-bound siRNA duplexes and thus the retention of the guide strand in holo-RISC (PubMed:32504809). (UniProtKB:Q9W4N2)" FBgn0000179 FlyBase Gene Snapshot "bifid (bi) encodes a T-box transcription factor that controls cell proliferation, viability and cell migration. It contributes to the development of several tissues such as brain, eyes and wings. In wing development it is activated by the product of dpp and to a lesser extent by Wg signaling." FBgn0029708 Alliance Predicted to enable cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor) and TCN1 (transcobalamin 1). FBgn0029709 FlyBase Gene Snapshot CHOp24 (CHOp24) encodes a p24 transporter that contributes to the intracellular trafficking between the ER and Golgi. It is required for secretion of Wnt ligands. FBgn0029710 Alliance Is expressed in spermatozoon. FBgn0029712 Alliance Predicted to be active in nucleus. Orthologous to human HDHD3 (haloacid dehalogenase like hydrolase domain containing 3). FBgn0029714 UniProtKB "S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes. S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (By similarity). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). (UniProtKB:Q9W4J5)" FBgn0022768 Alliance "Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of gene expression, epigenetic. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)." FBgn0029715 Alliance "Predicted to enable RNA binding activity. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human PDAP1 (PDGFA associated protein 1)." FBgn0029713 Alliance Is expressed in organism. Orthologous to human TTC17 (tetratricopeptide repeat domain 17). FBgn0029711 FlyBase Gene Snapshot Usf (Usf) encodes a bHLH family transcription factor that recognizes E-boxes in the Ste promoter. FBgn0003210 FlyBase Gene Snapshot "ruby (rb) encodes the beta3-adaptin subunit of the Adaptor protein-3 (AP-3) complex involved in biogenesis of lysosome-related organelles. It is required for regulation of lipid storage, eye pigment biogenesis and the processing of the receptor encoded by N." FBgn0011760 FlyBase Gene Snapshot "cut up (ctp) encodes the 8 kDa (LC8/DLC1) subunit of the cytoplasmic Dynein, as well as the Myosin V. It homodimerizes and binds to a variety of proteins. It is involved in both dynein-dependent and independent functions such as cell viability, axonal guidance, spermatid growth and individualization, and regulation of spermatogonial divisions." FBgn0028325 Alliance Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study disease of metabolism and retinal degeneration. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). FBgn0029722 Alliance Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of pyruvate dehydrogenase complex. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). FBgn0029727 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). FBgn0029733 Alliance Enables pH-gated chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in adult optic lobe; antenna; and nurse cell. FBgn0052772 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II." FBgn0029737 Alliance Predicted to enable heparan-alpha-glucosaminide N-acetyltransferase activity. Predicted to be involved in lysosomal transport. Predicted to be located in lysosomal membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type IIIC and retinitis pigmentosa 73. Orthologous to human HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase). FBgn0004368 FlyBase Gene Snapshot "Protein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr." FBgn0029725 Alliance Is expressed in adult head. FBgn0025679 Alliance Enables sequence-specific DNA binding activity. Involved in nephrocyte diaphragm assembly; nephrocyte differentiation; and response to silver ion. Predicted to be located in nucleus. Is expressed in adult pericardial cell; embryonic/larval garland cell; embryonic/larval pericardial cell; garland cell primordium; and organism. Used to study cardiomyopathy. Orthologous to human KLF15 (KLF transcription factor 15). FBgn0029745 Alliance "Predicted to enable endopeptidase activator activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, lid subcomplex." FBgn0003449 FlyBase Gene Snapshot sans fille (snf) encodes a protein component of U1 and U2 small nuclear ribonucleoproteins (snRNPs). U1 and U2 snRNPs combine with other snRNPs on the pre-mRNA to assemble a spliceosome. It contributes to alternative splicing regulation. FBgn0011761 FlyBase Gene Snapshot deadhead (dhd) encodes a thioredoxin-like protein necessary for the initiation of embryonic development. FBgn0029755 FlyBase Gene Snapshot "Something about silencing 10 (Sas10) encodes a protein belonging to the SAS10 family. It might be a substrate of the RNA deaminase encoded by Adar, which shows an adenosine to inosine (A-to-I) deaminase activity in pre-mRNA transcripts. The noncoding strand of the adjacent gene, Rnp4F, reads through to form a duplex with Sas10 transcripts at their 3'-end to target both transcripts for promiscuous A-to-I editing and degradation." FBgn0014024 FlyBase Gene Snapshot RNA-binding protein 4F (Rnp4F) encodes an essential evolutionarily-conserved RNA-binding protein. Rnp4F gene expression is post-transcriptionally regulated by interaction with a stable stem-loop structure in the 5'-UTR of the mRNA with trans-acting factors. FBgn0029754 Alliance Involved in male germ-line sex determination. Located in cytoplasm. FBgn0029752 UniProtKB Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline. (UniProtKB:Q8IFW4) FBgn0029751 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome." FBgn0029747 Alliance Predicted to be located in nucleoplasm. Is expressed in spermatozoon. FBgn0052767 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in organism; wing hinge primordium; and wing pouch. Orthologous to several human genes including ZNF136 (zinc finger protein 136); ZNF333 (zinc finger protein 333); and ZNF34 (zinc finger protein 34)." FBgn0026751 Alliance "Predicted to enable damaged DNA binding activity. Predicted to be involved in base-excision repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); central nervous system cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1)." FBgn0010014 UniProtKB "Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase. (UniProtKB:P48451)" FBgn0029761 FlyBase Gene Snapshot "small conductance calcium-activated potassium channel (SK) encodes a potassium channel subunit. Four SK subunits together form a voltage-independent potassium channel, which is activated by intracellular calcium levels and is required for normal photoreceptor light response. Contrary to its mammalian counterpart, Drosophila SK channel is not sensitive to apamin, at least not in photoreceptors." FBgn0029763 UniProtKB Involved in the regulation of DNA damage repair. (UniProtKB:Q9W4C3) FBgn0029765 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in wing disc. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to several human genes including LYZL1 (lysozyme like 1); LYZL2 (lysozyme like 2); and LYZL6 (lysozyme like 6). FBgn0029766 Alliance Is expressed in adult head and wing disc. FBgn0029768 UniProtKB "Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior (PubMed:18066048, PubMed:20308537, PubMed:20458515, PubMed:24089336, PubMed:25333796). MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons (PubMed:25333796). SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying (PubMed:18066048, PubMed:24089336). The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk) (PubMed:18066048, PubMed:24089336). (UniProtKB:Q8SWR3)" FBgn0029771 Alliance "Predicted to be active in membrane. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to several human genes including CMTM4 (CKLF like MARVEL transmembrane domain containing 4); CMTM6 (CKLF like MARVEL transmembrane domain containing 6); and CMTM8 (CKLF like MARVEL transmembrane domain containing 8)." FBgn0026702 Alliance "Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in rRNA processing and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Is expressed in organism. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Orthologous to human POP1 (POP1 homolog, ribonuclease P/MRP subunit)." FBgn0004687 FlyBase Gene Snapshot Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. FBgn0029778 FlyBase Gene Snapshot Rho GTPase activating protein at 5A (RhoGAP5A) encodes a GTPase activating protein involved in adherens junction maintenance and regulation of ERK MAP kinase signaling FBgn0029769 Alliance "Involved in negative regulation of female receptivity, post-mating. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1)." FBgn0029762 UniProtKB "Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine. (UniProtKB:Q9W4C5)" FBgn0029756 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in recycling endosome. Orthologous to human DENND6A (DENN domain containing 6A) and DENND6B (DENN domain containing 6B). FBgn0028474 Alliance "Predicted to enable mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism and spermatozoon. Orthologous to human RBM25 (RNA binding motif protein 25)." FBgn0029785 Alliance "A structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytosolic ribosome. Is expressed in organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 19. Orthologous to human RPL35 (ribosomal protein L35)." FBgn0003747 UniProtKB "Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (UniProtKB:Q9W497)" FBgn0000394 FlyBase Gene Snapshot crossveinless (cv) encodes a member of the tumor suppressor gene family of BMP binding proteins. Its primary function is to help specify the posterior crossvein during pupal wing development by enhancing Dpp/Gbb signaling. FBgn0029791 Alliance "Predicted to enable metalloendopeptidase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of imaginal disc-derived wing vein specification. Predicted to be active in extracellular matrix. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic epipharynx; embryonic hypopharynx; and presumptive wing vein. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and congenital heart disease. Orthologous to several human genes including ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) and ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7)." FBgn0029798 UniProtKB "ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates (By similarity). In male germline stem cells (GSCs), plays a role in GSCs maintenance during larval germline development by modulating the expression of genes such as Stat92E and preventing DNA damage-induced checkpoint activation (PubMed:34644293). May play a role in female germline stem cell maintenance (PubMed:34644293). (UniProtKB:Q9W484)" FBgn0029799 Alliance Predicted to enable structural molecule activity. Is expressed in adult head and organism. FBgn0029801 Alliance Predicted to enable N-acylneuraminate-9-phosphatase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Orthologous to human NANP (N-acetylneuraminic acid phosphatase). FBgn0029809 Alliance Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. FBgn0029810 Alliance Is expressed in embryonic brain; embryonic stomatogastric nervous system; and larval ventral nerve cord. FBgn0029811 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0029812 Alliance "Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to several human genes including PSMB7 (proteasome 20S subunit beta 7)." FBgn0029814 Alliance "Predicted to enable carbohydrate binding activity. Is expressed in several structures, including CNS glial cell; embryonic central brain neurons; embryonic/larval nervous system; ganglia; and ventral midline of embryo." FBgn0029820 Alliance Predicted to be involved in cAMP-mediated signaling. Predicted to be located in nucleus. Is expressed in adult head and organism. Orthologous to several human genes including TCP11L1 (t-complex 11 like 1) and TCP11L2 (t-complex 11 like 2). FBgn0029821 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult head and adult heart. FBgn0029822 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism." FBgn0029823 FlyBase Gene Snapshot "Serine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism." FBgn0029819 UniProtKB Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). (UniProtKB:Q9W462) FBgn0014340 FlyBase Gene Snapshot "males absent on the first (mof) encodes a MYST family histone acetyltransferase that acetylates the product of His4 at Lysine 16. It is part of the male-specific lethal complex that mediates dosage compensation by transcriptional upregulation of the male X chromosome. In addition, it is part of the non-specific lethal complex which regulates expression of housekeeping genes in males and females." FBgn0029818 FlyBase Gene Snapshot "Glycosylphosphatidylinositol anchor attachment 1 (GAA1) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane." FBgn0029813 Alliance Enables aralkylamine N-acetyltransferase activity. FBgn0029807 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). FBgn0029804 Alliance "Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including anal pad primordium; anlage in statu nascendi; epithelium; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6)." FBgn0013987 UniProtKB Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). (UniProtKB:P49071) FBgn0029800 FlyBase Gene Snapshot "lin-52 (lin-52) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle." FBgn0261383 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9W485)" FBgn0052758 Alliance Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). FBgn0053080 Alliance "Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head; embryonic Malpighian tubule; and embryonic Malpighian tubule tip cell." FBgn0027564 UniProtKB "Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues (By similarity). However, the intramembrane lipid transporter activity could not be confirmed in vitro (By similarity). (UniProtKB:Q9Y123)" FBgn0029789 UniProtKB Involved in inositol deacylation of GPI-anchored proteins. (UniProtKB:Q9W495) FBgn0046687 FlyBase Gene Snapshot "Trapped in endoderm 1 (Tre1) encodes a G protein-coupled receptor of the rhodopsin class. Its functions include primordial germ cell/pole cell migration and programmed cell death, central nervous system stem cell division orientation, and mating/courtship behavior." FBgn0015794 Alliance "Predicted to enable GTPase activity. Involved in macroautophagy. Located in Golgi apparatus; endoplasmic reticulum; and vacuole. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family)." FBgn0029783 UniProtKB NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (UniProtKB:Q8IRR5) FBgn0029824 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and organism. FBgn0052756 Alliance Is expressed in organism; pole plasm; and spermatozoon. FBgn0029826 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0052755 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0029827 Alliance Predicted to enable serine-type endopeptidase activity. Involved in regulation of terminal button organization. FBgn0029828 Alliance Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0029830 FlyBase Gene Snapshot Glutamate receptor binding protein (Grip) encodes a protein involved in muscle attachment and synapse organization. FBgn0029831 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic head sensory system; and gut section. Orthologous to several human genes including PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)) and PNLIPRP3 (pancreatic lipase related protein 3)." FBgn0029833 FlyBase Gene Snapshot "Malignant T cell amplified sequence 1 (MCTS1) encodes a protein that, together with its binding partner encoded by DENR, is a non-canonical translation initiation factor. It associates with ribosomes and it promotes translation reinitiation." FBgn0029834 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is expressed in adult head and spermatozoon. Orthologous to human ARFGEF3 (ARFGEF family member 3). FBgn0029835 Alliance Predicted to enable spectrin binding activity. Predicted to be involved in G2/M transition of mitotic cell cycle. Predicted to be located in apical part of cell. Predicted to be part of stereocilia ankle link complex. Predicted to be active in cilium; plasma membrane; and stereocilium tip. Human ortholog(s) of this gene implicated in Usher syndrome; Usher syndrome type 1; Usher syndrome type 1C; and autosomal recessive nonsyndromic deafness 18A. Orthologous to human USH1C (USH1 protein network component harmonin). FBgn0029843 FlyBase Gene Snapshot Neprilysin 1 (Nep1) encodes a plasma membrane bound metallopeptidase considered to cleave and thus inactivate signaling peptides in the extracellular space. It contributes to female and male fertility. FBgn0029849 FlyBase Gene Snapshot "ER GDP-fucose transporter (Efr) encodes a multifunctional endoplasmic reticulum nucleotide sugar transporter that transports GDP-fucose, UDP-N-acetylglucosamine and UDP-xylose from the cytosol into the ER lumen." FBgn0003514 FlyBase Gene Snapshot "spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis." FBgn0029848 FlyBase Gene Snapshot "Biotinidase (Btnd) encodes an enzyme that cleaves biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. It has also been shown to have biotinyl transferase activity." FBgn0040069 Alliance Predicted to enable pantetheine hydrolase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). FBgn0052751 Alliance Predicted to enable pantetheine hydrolase activity. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). FBgn0052750 Alliance Predicted to enable pantetheine hydrolase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). FBgn0026060 Alliance Predicted to enable acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; and inositol phosphate phosphatase activity. Predicted to be involved in TOR signaling. Predicted to be located in extracellular exosome. Predicted to be part of TORC1 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). FBgn0029840 FlyBase Gene Snapshot "raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism." FBgn0029839 Alliance Is expressed in adult head. Orthologous to human THEM6 (thioesterase superfamily member 6). FBgn0029838 Alliance "Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. Orthologous to human THEM6 (thioesterase superfamily member 6)." FBgn0029837 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including TSPAN4 (tetraspanin 4). FBgn0003302 UniProtKB Negative regulator of both mitosis and meiosis. Required for the establishment of the G1 phase in the developing eye. (UniProtKB:P50445) FBgn0029003 Alliance "Predicted to be involved in eye development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; dorsal epidermis primordium; ganglia; and head epidermis primordium. Used to study microphthalmia. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Orthologous to human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2)." FBgn0027546 Alliance Predicted to be involved in eye development. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Orthologous to human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2). FBgn0005390 FlyBase Gene Snapshot "female sterile (1) M3 (fs(1)M3) encodes a protein that is required, along with the products of fs(1)N and clos, for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation." FBgn0029851 Alliance Is expressed in adult head. FBgn0015818 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis; cervical cancer; and hepatocellular carcinoma. Orthologous to human SF3B4 (splicing factor 3b subunit 4)." FBgn0029853 UniProtKB May act as a deubiquitinating enzyme. (UniProtKB:Q9W422) FBgn0028982 UniProtKB "Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Required for the transcriptional induction of heat shock response genes and for maximal recruitment of two other elongation factors, Spt5 and Paf1, to the induced Hsp70. Plays a critical role in normal fly development throughout the lifecycle. (UniProtKB:Q9W420)" FBgn0029857 UniProtKB "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis. (UniProtKB:Q9W415)" FBgn0029858 FlyBase Gene Snapshot mulder (mldr) encodes a protein involved in mitochondrial tRNA processing. FBgn0029861 Alliance Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Part of Sin3-type complex. Is expressed in organism. Orthologous to human PHF12 (PHD finger protein 12). FBgn0029863 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0029864 Alliance Is expressed in adult head. FBgn0029866 Alliance "Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to human RDH11 (retinol dehydrogenase 11) and RDH12 (retinol dehydrogenase 12)." FBgn0029867 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm." FBgn0052748 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0029873 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Is expressed in organism. Orthologous to human SREK1IP1 (SREK1 interacting protein 1). FBgn0014031 FlyBase Gene Snapshot Alanine-glyoxylate aminotransferase (Agxt) encodes an enzyme involved in glyoxylate catabolism. FBgn0000524 UniProtKB "Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Regulates the sorting and degradation of N/Notch via an ESCRT-III dependent endolysosomal pathway (PubMed:22162134). (UniProtKB:Q23985)" FBgn0014026 FlyBase Gene Snapshot Ribosomal protein L7A (RpL7A) encodes a ribosomal structural constituent. FBgn0029874 Alliance Is expressed in organism. Orthologous to human FKBP15 (FKBP prolyl isomerase family member 15). FBgn0003139 FlyBase Gene Snapshot "Protein phosphatase V (PpV) encodes the catalytic subunit of the protein phosphatase 6 (PP6), which negatively regulates JNK and AMPK signaling. PpV product is essential for lipid homeostasis and Ras-induced tumorigenesis." FBgn0003655 UniProtKB "Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis. (UniProtKB:P40688)" FBgn0029868 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and oncocytic carcinoma of the thyroid. Orthologous to human NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). FBgn0043796 Alliance Enables DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. FBgn0028685 FlyBase Gene Snapshot "Regulatory particle triple-A ATPase 4 (Rpt4) encodes the 19S proteasomal ATPase, which is a component of the 26S proteosome complex. It localizes to the nucleolus and participates in regulating rRNA transcription. It physically interacts with the tumor suppressor encoded by BHD." FBgn0026015 FlyBase Gene Snapshot "Topoisomerase 3beta (Top3beta) encodes an RNA topoisomerase that participates in both transcription and translation. It promotes transcription by being recruited by the product of Tdrd3, an epigenetic reader recognizing dimethylarginine motifs in core histones. It contributes to translation by complexing with the product of Fmr1, an RNA-binding protein deficient in fragile X mental retardation syndrome." FBgn0029856 Alliance Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in determination of adult lifespan and negative regulation of reproductive process. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Is expressed in organism; polar primary spermatocyte; and testis. Orthologous to human UBB (ubiquitin B). FBgn0040918 FlyBase Gene Snapshot schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators. FBgn0023458 FlyBase Gene Snapshot "Rabconnectin-3A (Rbcn-3A) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It is involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells." FBgn0029877 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). FBgn0029878 FlyBase Gene Snapshot Protein interacting with APP tail-1 (Pat1) encodes a protein required for the product of Khc to transport cargo and to maximize its motility. In oocytes the products of Pat1 and Klc act in a redundant manner. FBgn0029879 FlyBase Gene Snapshot Anaphase Promoting Complex subunit 7 (APC7) encodes a protein that associates with the anaphase promoting complex/cyclosome (APC/C). It shows synergistic genetic interaction with the essential APC/C subunit encoded by Cdc23. The association of the product of APC7 and APC/C may be either transient or occurs only in certain forms of the APC/C complex. FBgn0029881 UniProtKB "Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons. (UniProtKB:Q9W3Y4)" FBgn0029880 UniProtKB Probable ATP-binding RNA helicase. (UniProtKB:Q9W3Y5) FBgn0028360 FlyBase Gene Snapshot "Cdc7 kinase (Cdc7) encodes a conserved protein kinase that is activated by the regulatory subunit encoded by chif during late G1/S of the cell cycle. The activated product of Cdc7 promotes the initiation of DNA replication through phosphorylation, and thereby activation, of the DNA helicase encoded by Mcm2 ." FBgn0062413 FlyBase Gene Snapshot Copper transporter 1A (Ctr1A) encodes a plasma membrane protein that functions as a copper transporter. It is required to drive neuropeptide maturation during normal growth and development. FBgn0025815 FlyBase Gene Snapshot "Minichromosome maintenance 6 (Mcm6) encodes a subunit of the hetero-hexameric mini-chromosome maintenance (MCM) Complex, which is the eukaryotic replicative DNA helicase. MCM complex requires association with CDC45L and the GINS complex for full helicase activity." FBgn0029895 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. Is expressed in spermatozoon; wing hinge primordium; and wing pouch. FBgn0029898 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. FBgn0029502 Alliance "Predicted to enable 3-demethoxyubiquinol 3-hydroxylase activity. Predicted to be involved in several processes, including determination of adult lifespan; regulation of reactive oxygen species metabolic process; and ubiquinone biosynthetic process. Predicted to be active in mitochondrial inner membrane and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 9 and primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase)." FBgn0029903 FlyBase Gene Snapshot pod1 (pod1) encodes a microtubule and actin filament binding protein involved in actin cytoskeleton reorganization and axon guidance. FBgn0029906 FlyBase Gene Snapshot xiantuan (xit) encodes a glucosyl transferase enzyme in the N-glycosylation pathway of the endoplasmic reticulum. It adds the three terminal glucose residues to oligosaccharyl-dolichol before the oligosaccharyl is transferred to newly synthesized proteins. It contributes to the control of gastrulation movements. FBgn0029907 FlyBase Gene Snapshot "Ataxin 1 (Atx-1) encodes the ortholog of human Atx-1, in which pathogenic variants with expanded glutamine tracts cause spinocerebellar ataxia type 1. It interacts with the product of sens via its AXH domain." FBgn0029909 FlyBase Gene Snapshot "muscarinic Acetylcholine Receptor, C-type (mAChR-C) encodes a G protein-coupled receptor activated by acetylcholine." FBgn0029905 FlyBase Gene Snapshot Nuclear factor Y-box C (Nf-YC) encodes a transcription factor involved in axon guidance. FBgn0003390 FlyBase Gene Snapshot shifted (shf) encodes a secreted protein that positively modulates Hedgehog signaling. It controls the diffusion of the lipid-modified protein encoded by hh by stabilizing its interaction with the heparan sulfate proteoglycans. FBgn0052740 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0029897 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPL17 (ribosomal protein L17). FBgn0029896 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including CNS glial cell; adult head; embryonic Malpighian tubule tip cell; epithelium; and ganglia. Orthologous to several human genes including SV2A (synaptic vesicle glycoprotein 2A)." FBgn0029894 Alliance Orthologous to human ZNF821 (zinc finger protein 821). FBgn0029892 Alliance "Predicted to enable diphthine methylesterase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be active in cytoplasm. Is expressed in several structures, including antennal anlage; antennal primordium; ganglia; gut section; and head epidermis primordium. Orthologous to human DPH7 (diphthamide biosynthesis 7)." FBgn0029887 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition. Predicted to be part of U1 snRNP and U2-type prespliceosome. Is expressed in several structures, including anterior endoderm; central brain primordium; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human LUC7L3 (LUC7 like 3 pre-mRNA splicing factor)." FBgn0029885 UniProtKB Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. (UniProtKB:Q9W3Y0) FBgn0029882 Alliance Predicted to enable S100 protein binding activity; tubulin binding activity; and ubiquitin protein ligase binding activity. Involved in heart development. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human CACYBP (calcyclin binding protein). FBgn0029912 Alliance Enables cargo receptor activity. Involved in intra-Golgi vesicle-mediated transport and vesicle tethering to Golgi. Is active in trans-Golgi network membrane. Orthologous to human TMF1 (TATA element modulatory factor 1). FBgn0029914 Alliance Is expressed in organism. Orthologous to human C6orf89 (chromosome 6 open reading frame 89). FBgn0029922 Alliance Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be active in cytoplasm. Is expressed in organism. FBgn0029924 Alliance "Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; adult heart; epithelial tube; and spermatozoon. Human ortholog(s) of this gene implicated in Mitchell syndrome; congenital bile acid synthesis defect 6; and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1)." FBgn0027108 FlyBase Gene Snapshot "Innexin 2 (Inx2) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the products of ogre or Inx3. It can also interact with cell adhesion forming components encoded by shg and arm. It contributes to epithelial organization and polarity of the embryonic epidermis, regulation of morphogen-dependent organ size and stem cell behavior." FBgn0052736 UniProtKB "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. (UniProtKB:Q9W3T5)" FBgn0029929 Alliance Is expressed in adult head and organism. Orthologous to human CCDC25 (coiled-coil domain containing 25). FBgn0029931 Alliance "Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; anlage in statu nascendi; anterior endoderm; and anterior endoderm anlage." FBgn0004143 UniProtKB "Actin-myosin network stability during cellularization. Might be involved in increasing actin-actin interactions or membrane-to-cytoskeleton attachments. nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. (UniProtKB:P32845)" FBgn0029932 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. FBgn0029937 Alliance Orthologous to several human genes including FAM177A1 (family with sequence similarity 177 member A1). FBgn0027342 UniProtKB "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. (UniProtKB:Q9NBW1)" FBgn0029936 Alliance Is expressed in organism. Orthologous to human HMGXB4 (HMG-box containing 4). FBgn0029935 Alliance Predicted to enable pore-forming activity. Predicted to be located in membrane. Is expressed in organism. Orthologous to human MMD (monocyte to macrophage differentiation associated) and MMD2 (monocyte to macrophage differentiation associated 2). FBgn0029928 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0000330 Alliance "Predicted to enable cargo adaptor activity. Involved in several processes, including Notch receptor processing; determination of adult lifespan; and exocytosis. Predicted to be part of AP-3 adaptor complex. Predicted to be active in cytoplasmic vesicle. Orthologous to several human genes including AP3M2 (adaptor related protein complex 3 subunit mu 2)." FBgn0027106 FlyBase Gene Snapshot Innexin 7 (Inx7) is one out of eight gap junction protein encoding genes in Drosophila. It is expressed in all embryonic epithelia from early to late stages of development and is found in glial and neuronal cells. It is functionally required for embryonic nervous system development. FBgn0004646 FlyBase Gene Snapshot "optic ganglion reduced (ogre) encodes one of the innexin subunits spanning the membrane 4 times. Together with the products of Inx2 and Inx3, it forms homo or hetero oligomers forming gap junctions, which allow the transfer of small solute between cells." FBgn0029925 Alliance Is expressed in adult head and organism. Orthologous to human LRRC57 (leucine rich repeat containing 57). FBgn0052732 UniProtKB Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-74'. (UniProtKB:Q9W3U1) FBgn0029915 Alliance Is expressed in optic lobe neuroepithelial cell. FBgn0029913 Alliance Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be active in extracellular region. Is expressed in organism. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). FBgn0029911 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in autophagosome-lysosome fusion. Located in cytoplasm. Orthologous to several human genes including ZNRF2 (zinc and ring finger 2). FBgn0029939 Alliance "Predicted to enable DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptide hormone secretion; neuroblast fate specification; and positive regulation of gene expression. Located in cytosol. Is expressed in several structures, including central brain; head epidermis primordium; proventriculus; sensory nervous system primordium; and ventral nerve cord. Used to study neurodegenerative disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; immunodeficiency 49; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BCL11 transcription factor A) and BCL11B (BCL11 transcription factor B)." FBgn0029942 Alliance Enables carboxylesterase activity. Predicted to be involved in cellular lipid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ABHD11 (abhydrolase domain containing 11). FBgn0029944 FlyBase Gene Snapshot Downstream of kinase (Dok) encodes a membrane-associated protein that functions upstream of the product of Shark to activate Jun kinase signaling during embryonic dorsal closure. FBgn0029945 Alliance Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). FBgn0026144 Alliance "Predicted to enable calcium ion binding activity. Involved in defense response to Gram-negative bacterium. Located in cytosol and nucleoplasm. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; head epidermis primordium; and mesoderm." FBgn0029950 Alliance Enables solute:sodium symporter activity. Predicted to be involved in sodium ion transport. Is active in plasma membrane. Is expressed in adult head; adult main segment of Malpighian tubule; ensheathing glial cell; larval ventral nerve cord; and lateral cord neurons. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0029949 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in mitochondrion. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). FBgn0029946 Alliance Is expressed in adult head. FBgn0029943 UniProtKB "Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). (UniProtKB:Q9W3R7)" FBgn0025549 UniProtKB Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. (UniProtKB:Q9XYQ2) FBgn0004198 FlyBase Gene Snapshot "cut (ct) encodes a homeoprotein that functions as a transcriptional factor in many different cells such as wing disc, muscle, oocyte and sense organ cells. It is a regulator of type-specific neuronal identity in the peripheral nervous system. ct is expressed at variable levels in the dendritic arborization (DA) neurons and these levels control the different dendritic morphologies specific for each class of DA neurons." FBgn0022786 FlyBase Gene Snapshot Hira (Hira) encodes a histone H3-H4 chaperone that specifically assembles nucleosomes containing the histone H3.3 variant. It is involved in various replication-independent nucleosome assembly processes and is critically required for de novo chromatin assembly in the male pronucleus. FBgn0029957 Alliance Is expressed in organism and spermatozoon. FBgn0029959 Alliance "Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of autophagosome maturation. Located in several cellular components, including Golgi apparatus; autolysosome membrane; and neuronal cell body. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Waisman syndrome and non-syndromic X-linked intellectual disability 72. Orthologous to human RAB39A (RAB39A, member RAS oncogene family) and RAB39B (RAB39B, member RAS oncogene family)." FBgn0016041 FlyBase Gene Snapshot "Translocase of outer membrane 40 (Tom40) encodes a protein predicted to be a channel component of the TOM complex, which is involved in protein import into mitochondria. It is predicted to be involved in the cellular response to hypoxia." FBgn0029961 Alliance "Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in membrane. Is expressed in several structures, including adult pharynx; gustatory receptor neurons; labellum; larval gnathal ganglion; and organism subdivision." FBgn0029958 FlyBase Gene Snapshot Pyruvate dehydrogenase phosphatase (Pdp) encodes an enzyme that regulates the BMP/DPP pathway via dephosporylation of the product encoded by Mad. FBgn0027553 UniProtKB "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. (UniProtKB:Q9Y113)" FBgn0029955 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0029962 Alliance Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Is expressed in adult head. Orthologous to human CA10 (carbonic anhydrase 10) and CA11 (carbonic anhydrase 11). FBgn0029964 Alliance Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in testis. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Megarbane-Dagher-Melike type. Orthologous to human PAM16 (presequence translocase associated motor 16). FBgn0029966 FlyBase Gene Snapshot "Ionotropic receptor 7c (Ir7c) encodes a tuning ionotropic receptor subunit that functions in aversive high salt taste neurons. It acts in a complex with Ir76b and Ir25a to mediate cation non-specific responses to high salt concentrations, but is only required for responses to monovalent cations." FBgn0029968 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in larval abdomen; larval external sense organ gustatory receptor neurons; and terminal organ. FBgn0040087 FlyBase Gene Snapshot p115 (p115) encodes a key protein of the early secretory pathway where it interacts with the product of GM130 and Rab proteins. p115 depletion from S2 cells leads to a fragmentation of the Golgi but without impairing transport efficiency. FBgn0010292 UniProtKB Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. (UniProtKB:P51406) FBgn0029975 FlyBase Gene Snapshot "spidey (spidey) encodes a member of the short chain dehydrogenase/reductase family. It regulates oenocyte growth and maturation, as well as the metabolism of ecdysteroids and cuticular hydrocarbons." FBgn0029976 FlyBase Gene Snapshot snazarus (snz) encodes a sorting nexin protein involved in lifespan. FBgn0004403 Alliance A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly and translation. Located in cytosolic ribosome. Is expressed in adult heart and organism. Human ortholog(s) of this gene implicated in chromosome 5q deletion syndrome. Orthologous to human RPS14 (ribosomal protein S14). FBgn0004404 Alliance A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly and translation. Located in cytosolic ribosome. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in chromosome 5q deletion syndrome. Orthologous to human RPS14 (ribosomal protein S14). FBgn0003447 FlyBase Gene Snapshot "singed (sn) encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The bundling activity of the product of sn is regulated by phosphorylation." FBgn0004657 FlyBase Gene Snapshot "myospheroid (mys) encodes a beta subunit of the integrin dimer. Integrin transmembrane receptors function as a link for the extracellular matrix and the intracellular actin cytoskeleton. The product of mys acts as adhesion/signaling protein regulating cellular adhesion, migration and survival." FBgn0029993 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be part of outer dynein arm. Is expressed in spermatogonium and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). FBgn0040319 FlyBase Gene Snapshot Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine. FBgn0029997 Alliance Enables myosin binding activity. Predicted to be involved in endocytosis. Is expressed in adult head and organism. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain). FBgn0029996 FlyBase Gene Snapshot Ubiquitin conjugating enzyme E2H (UbcE2H)encodes an E2 enzyme involved in protein ubiquitylation. It is involved in response to viral infection. FBgn0029995 Alliance Predicted to enable calcium ion binding activity. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). FBgn0029994 Alliance "Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Located in endoplasmic reticulum and lipid droplet. Is expressed in adult head; adult heart; embryonic/larval anterior midgut; embryonic/larval corpus allatum; and embryonic/larval fat body. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13); and RDH10 (retinol dehydrogenase 10)." FBgn0029992 FlyBase Gene Snapshot "Upf2 (Upf2) encodes a protein required for nonsense-mediated mRNA decay (NMD). It interacts directly with the product of Upf1 to identify and degrade NMD-substrate mRNAs, including mRNAs containing premature termination codons and a number of normal endogenous mRNAs." FBgn0004656 FlyBase Gene Snapshot "female sterile (1) homeotic (fs(1)h) encodes a Bromodomain and Extra-Terminal domain (BET) family of protein, characterized by the presence of two tandem bromodomains and an extra-terminal (ET) domain. BET proteins can bind acetylated lysine residues in histones and regulate transcription. The proteins encoded by fs(1)h and human BRD2 possess protein kinase activity." FBgn0029990 Alliance Is expressed in adult head; adult heart; and embryonic/larval fat body. FBgn0003656 FlyBase Gene Snapshot swiss cheese (sws) encodes a transmembrane protein that hydrolyzes phosphatidylcholine and binds to and inhibits the C3 catalytic subunit of protein kinase A. Its loss leads to neuronal and glial degeneration and apoptotic cell death. FBgn0029986 Alliance Is expressed in organism. FBgn0027280 Interactive Fly "chemokine-like protein that binds to phosphatidylserine (PS) - PS exposure on neurons is supplied cell-non-autonomously to coat dendrites> and to mediate interactions between PS and Draper, thus enabling phagocytosis - involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms - expressed in fat body, epidermal cells, trachea, hemocytes and glia - necessary for both axonal pruning and removal of axonal debris in the developing mushroom body" FBgn0029980 Alliance "Predicted to enable transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Predicted to be involved in polyprenol biosynthetic process. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; embryonic/larval midgut; and organism. Used to study retinitis pigmentosa 59. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit)." FBgn0029979 FlyBase Gene Snapshot maheshvara (mahe) encodes an RNA helicase. FBgn0029977 FlyBase Gene Snapshot hold'em (hdm) encodes an enzyme involved in photoreceptor synaptic transmission. FBgn0029974 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. FBgn0029971 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head. Orthologous to human NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1). FBgn0029970 FlyBase Gene Snapshot "Nek2 (Nek2) encodes a Ser/Thr kinase belonging to the NIMA family of kinases. It regulates centrosome disjunction, bipolar spindle formation, and kinetochore microtubule dynamics during mitosis. It also participates in meiosis by regulating chromatin condensation events." FBgn0029969 Alliance Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in acetyl-CoA biosynthetic process and fatty acid beta-oxidation. Located in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). FBgn0029965 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of terminal organ; gustatory receptor neuron of the hypophysis; terminal organ; and wing. FBgn0029963 Alliance Is expressed in adult head. Orthologous to human MTCH1 (mitochondrial carrier 1) and MTCH2 (mitochondrial carrier 2). FBgn0029999 Alliance Predicted to be part of MLL1 complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human TEX10 (testis expressed 10). FBgn0030003 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Predicted to be located in nucleus. Is expressed in organism." FBgn0030004 Alliance Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in chordotonal neurons; embryonic head sensory system; male germline cell; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21 and spermatogenic failure. Orthologous to human DRC1 (dynein regulatory complex subunit 1). FBgn0030005 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic hindgut and organism." FBgn0030008 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of heterochromatin. Is expressed in organism. Orthologous to human ZNF497 (zinc finger protein 497)." FBgn0030009 Alliance Predicted to enable sequence-specific DNA binding activity. Is expressed in organism. FBgn0030010 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in organism." FBgn0030012 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. FBgn0030013 Alliance Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Is expressed in germline cell; organism; and primordial germ cell. Orthologous to human PLA2G3 (phospholipase A2 group III). FBgn0030014 Alliance Is expressed in organism. FBgn0030025 Alliance "Is expressed in several structures, including central brain primordium; embryonic brain; embryonic/larval visceral muscle cell; trunk mesoderm; and visceral muscle primordium." FBgn0020653 UniProtKB "Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms. (UniProtKB:P91938)" FBgn0030027 Alliance Predicted to be involved in proteolysis. Is expressed in spermatozoon. FBgn0030030 Alliance Is expressed in adult head. FBgn0030033 Alliance Is expressed in spermatozoon. FBgn0030034 Alliance Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in synovial sarcoma. Orthologous to human SS18L2 (SS18 like 2); SS18 (SS18 subunit of BAF chromatin remodeling complex); and SS18L1 (SS18L1 subunit of BAF chromatin remodeling complex). FBgn0030035 Alliance "Predicted to be involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in several structures, including adult head; embryonic midline of ventral nerve cord; embryonic/larval brain; follicle cell; and imaginal disc. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T)." FBgn0040928 Alliance Is expressed in organism. FBgn0015519 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor alpha3 (nAChRalpha3) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel." FBgn0030029 Alliance Predicted to enable pyridoxamine phosphate oxidase activity. Predicted to be involved in pyridoxal phosphate biosynthetic process. FBgn0030028 FlyBase Gene Snapshot Companion of reaper (Corp) is a gene that is transcriptionally induced following DNA damage. It may function to inhibit the pro-apoptotic activity of the transcriptional factor encoded by p53. FBgn0017566 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity). (UniProtKB:Q94511) FBgn0030026 FlyBase Gene Snapshot sniffer (sni) encodes a homodimeric carbonyl reductase that belongs to the SDR superfamily of proteins. It catalyzes the reduction of the lipid derived aldehyde 4-oxononenal. It contributes to protection against oxidative stress-induced neurodegeneration and prevention of apoptosis by removal of damaged cardiolipin. FBgn0030016 FlyBase Gene Snapshot Odorant receptor 7a (Or7a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0030015 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein polyubiquitination and regulation of mitochondrial fission. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). FBgn0030011 Alliance "Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic central brain neurons; embryonic head sensory system; embryonic/larval midgut; ganglia; and organism subdivision. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Orthologous to human GNB5 (G protein subunit beta 5)." FBgn0030007 FlyBase Gene Snapshot "Phenylalanyl-tRNA synthetase, alpha-subunit (alpha-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the beta-subunit it forms a tetrameric enzyme complex. This subunit provides the catalytic core." FBgn0025800 FlyBase Gene Snapshot "Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes." FBgn0030001 Alliance "Predicted to be involved in epithelial cell morphogenesis. Predicted to be located in membrane. Is expressed in several structures, including embryonic dorsal epidermis; embryonic head sensory system; embryonic labial sensory complex; gut section; and labial sensory complex primordium." FBgn0030000 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human WDR46 (WD repeat domain 46)." FBgn0030038 Alliance "Predicted to enable aminopeptidase activity and cysteine-type peptidase activity. Predicted to be involved in homocysteine catabolic process and response to toxic substance. Located in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult brain; epithelium; gut section; and head epidermis primordium. Orthologous to human BLMH (bleomycin hydrolase)." FBgn0023506 Alliance Predicted to be involved in nervous system development. Part of catalytic step 2 spliceosome. Orthologous to human ESS2 (ess-2 splicing factor homolog). FBgn0014465 FlyBase Gene Snapshot Chorion protein b at 7F (Cp7Fb) belongs to a family of nine Chorion protein genes clustered in two chromosomes (X and 3rd). It is expressed in the follicle cells in a dynamic pattern. FBgn0014466 FlyBase Gene Snapshot Chorion protein c at 7F (Cp7Fc) belongs to a family of nine Chorion protein genes clustered in two chromosomes (X and 3rd). It is expressed in the follicle cells in a dynamic pattern. FBgn0000359 FlyBase Gene Snapshot Chorion protein 36 (Cp36) encodes an abundant structural protein of the eggshell whose expression is enhanced by gene amplification in ovarian follicle cells. It is essential for fertility and for endochorion integrity. FBgn0000360 Alliance A structural constituent of egg chorion. Involved in chorion-containing eggshell formation. Located in egg chorion. Is expressed in adult heart; follicle cell; and ovary. FBgn0053181 Alliance Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in monoatomic cation transport. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including SLC41A1 (solute carrier family 41 member 1) and SLC41A2 (solute carrier family 41 member 2). FBgn0030049 UniProtKB "Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information (PubMed:18765642, PubMed:26786835). Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (PubMed:26786835). Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs (PubMed:18765642, PubMed:26786835). (UniProtKB:Q7KVS9)" FBgn0030052 Alliance Predicted to enable catalytic activity. Predicted to be involved in nucleoside metabolic process. Is expressed in adult head. FBgn0030053 Alliance Predicted to enable chromatin binding activity. Predicted to be part of chromatin. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human KLHDC3 (kelch domain containing 3). FBgn0025864 FlyBase Gene Snapshot Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein (Crag) encodes a guanine exchange factor for the products of Rab10 and Rab11. It is involved in the exclusive secretion of basement membrane proteins on the basal side of cells. FBgn0030055 Alliance Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in negative regulation of autophagy. Predicted to be located in early endosome. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to several human genes including RUBCN (rubicon autophagy regulator). FBgn0030056 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. FBgn0027864 FlyBase Gene Snapshot "8-oxoguanine DNA glycosylase (Ogg1) encodes the DNA glycosylase required for removal of 8-oxo guanines from nuclei. Depletion of Ogg1 resulted in accumulation of the oxidized guanines in nuclei of adult intestines, treated with an oxidative stress inducer. Conversely, its overexpression conferred the resistance to oxidative stress and a significantly longer lifespan." FBgn0030058 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to several human genes including ESX1 (ESX homeobox 1); RHOXF1 (Rhox homeobox family member 1); and RHOXF2 (Rhox homeobox family member 2)." FBgn0030057 FlyBase Gene Snapshot Palmitoyl-protein thioesterase 1 (Ppt1) encodes a lysosomal enzyme that removes palmitoyl groups from particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins. FBgn0030054 FlyBase Gene Snapshot "Chromatin assembly factor 1, p180 subunit (Caf1-180) encodes a component of the chromatin assembly factor-1, which couples DNA replication to histone deposition. The product of Caf1-180 is involved in nucleosome organization, DNA endoduplication and double-strand DNA break repair." FBgn0040929 Alliance Predicted to be involved in chromatin remodeling. Predicted to be part of Ino80 complex. Is expressed in organism. Orthologous to human INO80C (INO80 complex subunit C). FBgn0030051 Alliance Predicted to enable serine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade and defense response to other organism. Predicted to be located in extracellular region. FBgn0030050 Alliance Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Is expressed in adult head and organism. FBgn0026679 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Essential for development (PubMed:21078872). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9W3E1)" FBgn0024943 UniProtKB Required for the morphological differentiation and maintenance of the rhabdomeric photoreceptor apical domain (PubMed:32579558). Acts as a downstream component of the gl and Pph13 transcriptional pathway which is required for photoreceptor cell development (PubMed:32579558). Likely to function by regulating the trafficking or retention of rhabdomeric proteins including the phototransduction proteins ninaE and didum (PubMed:32579558). (UniProtKB:Q9W3E2) FBgn0003023 UniProtKB Essential for female fertility; germ cell division and differentiation. (UniProtKB:P10383) FBgn0030041 Alliance Predicted to enable sepiapterin reductase (NADP+) activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). FBgn0014032 FlyBase Gene Snapshot Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin. FBgn0030040 Alliance Is expressed in adult head; amnioserosa; gastric caecum; gut section; and yolk nucleus. FBgn0021767 FlyBase Gene Snapshot optomotor-blind-related-gene-1 (org-1) encodes a T-box transcription factor involved in the combinatorial activation of somatic muscle lineage-specific targets. FBgn0030037 UniProtKB Regulator of mitochondrial fusion required to maintain neuronal homeostasis. (UniProtKB:Q9W3F7) FBgn0041629 FlyBase Gene Snapshot Hexosaminidase 2 (Hexo2) encodes a beta-N-acetylglucosaminidase involved in carbohydrate metabolism. FBgn0030061 UniProtKB "May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit. (UniProtKB:Q9W3C2)" FBgn0030063 UniProtKB Involved in nucleolar processing of pre-18S ribosomal RNA. (UniProtKB:Q9W3C0) FBgn0030065 Alliance "Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic anal pad; gland; and gut section." FBgn0030067 Alliance "Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human MAK16 (MAK16 homolog)." FBgn0030073 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in several structures, including embryonic/larval visceral muscle cell; gut section; and wing disc. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0030071 Alliance Predicted to be active in cytoplasm. Orthologous to human FAM136A (family with sequence similarity 136 member A). FBgn0011586 UniProtKB Acts as an enhancer of the rudimentary gene. Has a role in pyrimidine biosynthesis and the cell cycle. (UniProtKB:Q24337) FBgn0030066 Alliance Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). FBgn0011661 FlyBase Gene Snapshot "Moesin (Moe) encodes an Ezrin, Radixin, Moesin (ERM) protein involved in cortical cytoskeleton stability. It regulates the products of crb and Rho1. The product of Moe contributes to apical-basal polarity, mitotic spindle organisation and epithelial integrity." FBgn0026411 FlyBase Gene Snapshot LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. FBgn0027330 UniProtKB "RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility (PubMed:11493925). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). (UniProtKB:Q9W3C1)" FBgn0030060 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0030082 FlyBase Gene Snapshot Heterochromatin Protein 1b (HP1b) encodes a chromatin binding protein that negatively regulates transcription and heterochromatin formation. FBgn0052707 Alliance Involved in protein catabolic process. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Is expressed in organism. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). FBgn0052708 Alliance Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be active in nucleolus. Is expressed in embryonic/larval midgut; embryonic/larval visceral muscle cell; and organism. Orthologous to human ABT1 (activator of basal transcription 1). FBgn0052706 Alliance Predicted to enable RNA binding activity. Involved in defense response to bacterium. Predicted to be active in nucleolus. Is expressed in fat body/gonad primordium and gonad. Orthologous to human ABT1 (activator of basal transcription 1). FBgn0030085 Alliance "Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in fat body/gonad primordium and gonad. Orthologous to human ABT1 (activator of basal transcription 1)." FBgn0030086 Alliance "Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Used to study candidiasis. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2)." FBgn0030088 Alliance Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in Golgi to plasma membrane protein transport; intracellular protein transport; and protein localization to Golgi apparatus. Predicted to be active in Golgi apparatus. Is expressed in adult head. Orthologous to human ARFRP1 (ADP ribosylation factor related protein 1). FBgn0030089 FlyBase Gene Snapshot "Adaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking." FBgn0030091 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. FBgn0030093 FlyBase Gene Snapshot Brahma associated protein 111kD (Bap111) encodes a protein important for Brahma complex function. It is involved in chromatin remodeling and transcription induction. FBgn0040467 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. Is expressed in organism and yolk nucleus. FBgn0026206 FlyBase Gene Snapshot "meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis." FBgn0030099 UniProtKB Heme-binding protein. (UniProtKB:Q9W376) FBgn0030100 Alliance Predicted to be involved in sodium ion transport. Is expressed in organism. Orthologous to human COMMD3 (COMM domain containing 3). FBgn0030103 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. FBgn0030104 Alliance Predicted to enable zinc ion binding activity. Orthologous to human ZFAND5 (zinc finger AN1-type containing 5) and ZFAND6 (zinc finger AN1-type containing 6). FBgn0030105 Alliance Predicted to enable cysteine-type endopeptidase inhibitor activity. FBgn0030108 UniProtKB "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing and avoiding L-canavanine, a plant-derived insecticide. (UniProtKB:Q9W367)" FBgn0010269 FlyBase Gene Snapshot "Downstream of raf1 (Dsor1) encodes a serine/threonine kinase that phosphorylates MAP kinase. It is activated by the product of Raf and acts downstream of receptor tyrosine kinases such as those encoded by tor, Egfr, and sev." FBgn0030114 Alliance Is expressed in amnioserosa; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to several human genes including KLHL5 (kelch like family member 5). FBgn0028292 FlyBase Gene Snapshot "ric8a (ric8a) encodes a guanine nucleotide-exchange factor for the product of Galphai. Its function is necessary to ensure cortical localization of the heterotrimeric subunits encoded by Galphai and Gbeta13F, thereby regulating spindle orientation during asymmetric cell division in the sensory lineage." FBgn0030122 UniProtKB Involved in mitotic spindle assembly. (UniProtKB:Q9W351) FBgn0002576 FlyBase Gene Snapshot "lozenge (lz) encodes an alpha-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It plays an important role during eye development contributing to programmed cell death, eye morphogenesis, eye cone cell differentiation and R7 cell development. It contributes to hemopoiesis and wound healing." FBgn0040234 Alliance Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human VWA8 (von Willebrand factor A domain containing 8). FBgn0040235 UniProtKB Involved in pre-mRNA splicing. (UniProtKB:Q9V3B6) FBgn0040236 Alliance Located in Golgi apparatus and late endosome. Is expressed in adult head and organism. Orthologous to several human genes including MROH1 (maestro heat like repeat family member 1). FBgn0030121 FlyBase Gene Snapshot "CXXC finger protein 1 (Cfp1) encodes a protein that is thought to help target the Set1/COMPASS histone methyltransferase complex to CpG rich regions of the genome, including gene promoters." FBgn0030120 Alliance Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). FBgn0052703 FlyBase Gene Snapshot Extracellularly regulated kinase 7 (Erk7) encodes an unconventional ERK family member with a role in the organization of the early secretory pathway. FBgn0000077 UniProtKB "Positive regulator of Notch signaling during lateral inhibition and boundary formation (PubMed:14595834, PubMed:18331889, PubMed:34905536). Interacts with Notch signaling at the membrane, at the level of gamma-secretase-mediated S3 cleavage (PubMed:18331889, PubMed:34905536). May regulate Notch signaling by regulating the subcellular localization of N/Notch in a context dependent manner (PubMed:31782145, PubMed:34905536). Maternal neurogenic factor involved in Notch signaling-dependent mesectodermal and neuroectodermal specification during early embryogenesis (PubMed:14595834, PubMed:18331889, PubMed:31782145, PubMed:34905536). Functions cooperatively with bisc/TM2D1 and amrt/TM2D2 (PubMed:34905536). Required for maintenance of neuronal function (PubMed:34905536). Involved in imaginal specification of eyes and wings (PubMed:18331889). (UniProtKB:Q9U4H5)" FBgn0052704 FlyBase Gene Snapshot Ionotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids. FBgn0030109 Alliance Predicted to be active in Golgi apparatus and membrane. Is expressed in adult head. Orthologous to human GPR107 (G protein-coupled receptor 107) and GPR108 (G protein-coupled receptor 108). FBgn0030102 Alliance Predicted to enable histone deacetylase binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in adult head. FBgn0030101 Alliance Predicted to be involved in cobalamin metabolic process. Located in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblD. Orthologous to human MMADHC (metabolism of cobalamin associated D). FBgn0030096 FlyBase Gene Snapshot Zpr1 (Zpr1) encodes a protein that functions downstream of the EGFR and other tyrosine kinase receptors. It also contributes to the assembly of spliceosome snRNPs. In the developing tracheal system it is required for terminal cell lumen formation. FBgn0040931 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; epithelium; somatic mesoderm; and visceral mesoderm." FBgn0014868 UniProtKB "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity). (UniProtKB:Q24319)" FBgn0030092 FlyBase Gene Snapshot frataxin (fh) encodes an essential nuclear encoded protein located in the mitochondrial inner membrane. It is involved in the synthesis of iron-sulfur clusters which are required for ATP production by the respiratory chain as well as other biological processes such as steroidogenesis. The levels of the product of fh are also crucial for protection of the product of mAcon1 against oxidative stress and iron homeostasis. FBgn0030090 FlyBase Gene Snapshot forked end (fend) encodes a transmembrane protein that contributes to selective target selection in the neuromuscular system. FBgn0004856 FlyBase Gene Snapshot Bx42 (Bx42) encodes a nuclear protein that acts as a cofactor in Notch signalling pathway. FBgn0030087 UniProtKB "Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (By similarity). (UniProtKB:Q9W391)" FBgn0030081 Alliance "Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human UTP6 (UTP6 small subunit processome component)." FBgn0030077 Alliance Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1); LZTS2 (leucine zipper tumor suppressor 2); and LZTS3 (leucine zipper tumor suppressor family member 3). FBgn0026149 Alliance "Is expressed in several structures, including antennal anlage; central brain anlage; central brain primordium; dorsal head epidermis anlage; and ganglia. Orthologous to several human genes including BCL7B (BAF chromatin remodeling complex subunit BCL7B) and BCL7C (BAF chromatin remodeling complex subunit BCL7C)." FBgn0030136 Alliance A structural constituent of ribosome. Predicted to be involved in maturation of SSU-rRNA and ribosomal small subunit assembly. Located in cytosolic ribosome. Is expressed in adult heart. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). FBgn0001186 FlyBase Gene Snapshot "Hexokinase A (Hex-A) encodes an enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexoses D-glucose, D-fructose and D-mannose to D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively. It mediates the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate." FBgn0030141 FlyBase Gene Snapshot "Golgi-localized, gamma-adaptin ear containing, ARF binding protein (Gga) encodes a clathrin binding protein involved in post-Golgi vesicle-mediated transport." FBgn0027084 Alliance "Predicted to enable lysine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in lysyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; germline cell; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1)." FBgn0052699 FlyBase Gene Snapshot "Lysophosphatidylcholine acyltransferase (LPCAT) encodes an enzyme involved in the synthesis of the major membrane lipid phosphatidylcholine. Combined with the activity of the phospholipase encoded by Pla2, it allows exchange of fatty acids on the sn-2 position, which is the major pathway to introduce polyunsaturated fatty acids into membrane phospholipids." FBgn0052702 UniProtKB "Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless. (UniProtKB:Q9W332)" FBgn0028327 Alliance "Located in endoplasmic reticulum and fusome. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; epithelium; gut section; and mesoderm. Orthologous to human SSR1 (signal sequence receptor subunit 1)." FBgn0000233 FlyBase Gene Snapshot "buttonhead (btd) encodes a triple C(2)H(2) zinc finger protein structurally and functionally related to the human transcription factors Sp5, Sp8, and Sp9. The product of btd contributes to embryonic head segmentation, leg development, embryonic hematopoiesis, PNS formation, and maintenance of the functional heterogeneity of brain neural stem cells." FBgn0020378 FlyBase Gene Snapshot "Sp1 (Sp1) encodes a member of the Sp-family of Cys2His2-type zinc finger transcription factors. It is involved in ventral thoracic appendage specification, leg growth and in the development of type-II neuroblasts." FBgn0052698 Alliance Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Orthologous to human CA10 (carbonic anhydrase 10) and CA11 (carbonic anhydrase 11). FBgn0026415 UniProtKB "Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex. (UniProtKB:Q9W303)" FBgn0030148 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in adult head; embryonic/larval gut; embryonic/larval midgut; and gastric caecum." FBgn0030164 Alliance Predicted to enable G protein-coupled receptor binding activity and chitin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human TNR (tenascin R). FBgn0052694 Alliance "Is expressed in several structures, including adult fat body; adult head; embryonic dorsal epidermis; embryonic epipharynx; and gut section." FBgn0004045 UniProtKB "Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Along with Yp2 and Yp3, and their receptor yl/yolkless, required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex (PubMed:33891588). (UniProtKB:P02843)" FBgn0052693 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IRL8)" FBgn0030174 Alliance Predicted to be active in neuron projection. Is expressed in organism. FBgn0005391 UniProtKB "Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Vitellogenins and their receptor yl/yolkless are required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex (PubMed:33891588). (UniProtKB:P02844)" FBgn0030163 Alliance Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human TNR (tenascin R). FBgn0030177 Alliance "Predicted to enable RNA endonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be part of preribosome, small subunit precursor. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog)." FBgn0030181 Alliance Predicted to enable zinc ion binding activity. FBgn0028342 Alliance "Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Used to study mitochondrial complex V (ATP synthase) deficiency nuclear type 5. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 5. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta)." FBgn0030189 Alliance Is expressed in organism and wing disc. FBgn0028480 Alliance "Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval oenocyte; gastric caecum; and gut section. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human TLCD3A (TLC domain containing 3A) and TLCD3B (TLC domain containing 3B)." FBgn0000711 UniProtKB Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development. (UniProtKB:P48462) FBgn0030200 Alliance Predicted to enable GTPase activity. Predicted to be involved in Rab protein signal transduction; endocytic recycling; and secretion by cell. Predicted to be located in vesicle. Predicted to be active in cytoplasmic vesicle and plasma membrane. FBgn0030206 Alliance Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism. FBgn0030208 UniProtKB Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). (UniProtKB:Q9W2U4) FBgn0052687 Alliance Predicted to be involved in signal transduction. Is expressed in embryonic/larval fat body; embryonic/larval midgut; embryonic/larval posterior spiracle; yolk; and yolk nucleus. Orthologous to human LRRC58 (leucine rich repeat containing 58). FBgn0030207 Alliance Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Orthologous to human DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). FBgn0030204 FlyBase Gene Snapshot Odorant receptor 9a (Or9a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0052683 Alliance Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor internalization. Located in plasma membrane. FBgn0030196 Alliance Predicted to be involved in mitotic DNA replication initiation. Part of CMG complex and GINS complex. Is expressed in organism. Orthologous to human GINS3 (GINS complex subunit 3). FBgn0052681 Alliance Is expressed in spermatozoon. FBgn0052686 Alliance Is expressed in spermatozoon. FBgn0052679 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to several human genes including R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0028331 Alliance "Is expressed in several structures, including adult head; embryonic anal pad; embryonic hypopharynx; embryonic/larval muscle system; and gut section. Orthologous to human PLXDC1 (plexin domain containing 1) and PLXDC2 (plexin domain containing 2)." FBgn0030191 Alliance Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to be active in microtubule cytoskeleton. Is expressed in adult head. FBgn0011770 UniProtKB Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). (UniProtKB:P36951) FBgn0030187 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0030186 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in embryonic dorsal epidermis and embryonic ventral epidermis. FBgn0030183 UniProtKB "Involved in regulating synaptic transmission in presynaptic neurons (PubMed:32461240). In class IV dendritic arborization neurons (nociceptors), involved in regulating activation of their second-order neurons (SONs) and maintaining synaptic contact between nociceptors and their SONs (PubMed:32461240). (UniProtKB:Q9W2X7)" FBgn0030178 UniProtKB "Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (UniProtKB:Q9W2Y3)" FBgn0052685 Alliance "Enables protein phosphatase 1 binding activity. Predicted to be involved in regulation of telomere maintenance. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; head epidermis primordium; and mesoderm. Orthologous to human YLPM1 (YLP motif containing 1)." FBgn0067052 Alliance Predicted to enable GTPase activity. Predicted to be involved in Rab protein signal transduction; endocytic recycling; and secretion by cell. Predicted to be located in vesicle. Predicted to be active in cytoplasmic vesicle and plasma membrane. FBgn0030217 Alliance Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in spermatozoon. Orthologous to human FASTKD5 (FAST kinase domains 5). FBgn0030223 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. FBgn0052677 Alliance Involved in protein localization to membrane. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Is expressed in embryonic/larval brain; embryonic/larval central nervous system; and larval ventral nerve cord. Orthologous to several human genes including APBA1 (amyloid beta precursor protein binding family A member 1) and APBA2 (amyloid beta precursor protein binding family A member 2). FBgn0003204 UniProtKB "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (UniProtKB:Q07152)" FBgn0030228 FlyBase Gene Snapshot BTB (POZ) domain containing 9 (BTBD9) encodes a protein that regulates brain dopamine levels and the circadian sleep/wake cycle. FBgn0052672 FlyBase Gene Snapshot "Autophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan." FBgn0052675 Alliance Involved in Golgi organization and protein secretion. Located in endoplasmic reticulum. Is expressed in adult head. Orthologous to human VMP1 (vacuole membrane protein 1). FBgn0030230 Alliance Enables small GTPase binding activity. Predicted to be involved in intracellular protein transport; neurotransmitter secretion; and regulation of calcium ion-dependent exocytosis. Predicted to be located in secretory granule and synaptic vesicle membrane. Predicted to be active in synapse. Used to study cardiomyopathy. Orthologous to several human genes including RPH3A (rabphilin 3A). FBgn0052676 FlyBase Gene Snapshot stuxnet (stx) encodes a protein that controls the homeostasis of the product of Pc via proteasomal degradation through an ubiquitin-independent pathway. FBgn0052673 Alliance Predicted to enable GTPase activity. Predicted to be involved in Rab protein signal transduction; endocytic recycling; and secretion by cell. Predicted to be located in vesicle. Predicted to be active in cytoplasmic vesicle and plasma membrane. FBgn0030222 Alliance Predicted to enable zinc ion binding activity. Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. FBgn0030221 Alliance Predicted to enable GTPase activity. Predicted to be involved in Rab protein signal transduction; endocytic recycling; and secretion by cell. Predicted to be located in vesicle. Predicted to be active in cytoplasmic vesicle and plasma membrane. FBgn0030218 Alliance Predicted to enable L-ornithine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be located in mitochondrial envelope. Predicted to be active in mitochondrion. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to human SLC25A15 (solute carrier family 25 member 15) and SLC25A2 (solute carrier family 25 member 2). FBgn0001206 FlyBase Gene Snapshot Hybrid male rescue (Hmr) encodes a protein required to repress transposable element and satellite DNA expression. It also has a gain-of-function phenotype of causing lethality in F1 male hybrids between D. melanogaster and D. simulans. FBgn0030215 Alliance Predicted to be involved in cristae formation. Predicted to be part of MICOS complex. Predicted to be active in mitochondrial crista junction. Is expressed in adult head. FBgn0034551 Alliance Predicted to be located in extracellular space. FBgn0034554 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. FBgn0050295 UniProtKB "Contributes to the formation of Ins(1,2,3,4,5,6)P6 (InsP6, IP6 or phytate) (PubMed:15322119). Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form InsP6 (Probable). Together with Ipk2, they are the main contributors to higher InsP synthesis (PubMed:15322119). (UniProtKB:Q9W2Q7)" FBgn0034558 UniProtKB Calcium- and integrin-binding protein (By similarity). Plays a role in intracellular calcium homeostasis (PubMed:23023331). Critical for proper photoreceptor cell maintenance and function (PubMed:23023331). Required for prevention of light-dependent retinal degeneration (PubMed:23023331). (UniProtKB:Q9W2Q5) FBgn0034560 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. FBgn0020617 FlyBase Gene Snapshot "Retinal Homeobox (Rx) encodes a homeodomain transcription factor required for processes of brain development. It is involved in growth regulation, proliferation and cell survival." FBgn0034564 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and maturation of SSU-rRNA. Predicted to be part of sno(s)RNA-containing ribonucleoprotein complex; spliceosomal complex; and spliceosomal snRNP complex. Predicted to be active in P-body and nucleolus. Is expressed in organism. Orthologous to human LSM6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)." FBgn0034570 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in gravitaxis. Predicted to be active in nucleus. Is expressed in organism." FBgn0034572 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in RNA processing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; hindgut anlage; and hindgut proper primordium. Orthologous to human U2SURP (U2 snRNP associated SURP domain containing)." FBgn0050296 FlyBase Gene Snapshot RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. FBgn0034576 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in communication disorder and nuclear type mitochondrial complex I deficiency 14. Orthologous to human NDUFA11 (NADH:ubiquinone oxidoreductase subunit A11)." FBgn0034579 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL54 (mitochondrial ribosomal protein L54). FBgn0034580 Alliance "Predicted to enable chitin binding activity and chitinase activity. Involved in ecdysis, chitin-based cuticle. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic)." FBgn0003748 FlyBase Gene Snapshot Trehalase (Treh) encodes an enzyme that hydrolyzes the the disaccharide trehalose to two molecules of glucose in either the cytoplasm or the extracellular space. FBgn0034583 Alliance "Located in cytoplasm. Is expressed in several structures, including adult head; female germline cell; follicle cell; gland; and glial cell." FBgn0034582 FlyBase Gene Snapshot Chitinase 9 (Cht9) encodes an enzyme involved in the formation of chitin-based extracellular matrix at barrier tissues. FBgn0022700 FlyBase Gene Snapshot Chitinase 4 (Cht4) encodes a chitin binding protein with chitinolytic activity. FBgn0050293 FlyBase Gene Snapshot "Chitinase 12 (Cht12) encodes an enzyme involved in cuticle development, ecdysis and wound healing." FBgn0034578 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human COA1 (cytochrome c oxidase assembly factor 1). FBgn0003391 UniProtKB "Cadherins are calcium-dependent cell adhesion proteins (PubMed:7958432). In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:7958432). During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte (PubMed:24855950, PubMed:30763317). Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surrounding nurse cells (PubMed:24855950). This adhesion increases Rac1 signaling in the leading cells, which in turn stabilizes DE-cadherin/DE-cadherin adhesions through the formation of forward-directed protrusions which attach/detach to the surrounding nurse cells in order to pull the cluster through the egg chamber to the oocyte (PubMed:24855950). Within the BC cluster, also promotes adhesion between BCs, and between BCs and polar cells which enables the lead BC to communicate direction to the other cells in the cluster, providing polarity to each individual cell and ensuring collective behavior (PubMed:24855950, PubMed:30763317). May function in cell intercalation in the lateral epidermis during germband extension (PubMed:24681004). Contributes to the determination of body left-right asymmetry by enhancing Myo31DF activity and inhibiting Myo61F activity (PubMed:22491943). (UniProtKB:Q24298)" FBgn0034573 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of GID complex. Is expressed in organism. Orthologous to human RMND5A (required for meiotic nuclear division 5 homolog A) and RMND5B (required for meiotic nuclear division 5 homolog B). FBgn0001133 FlyBase Gene Snapshot "grauzone (grau) encodes a transcription factor with the Cdc20 activator of the Anaphase Promoting Complex (APC) encoded by cort as key target. Absence of grau function results in the cort phenotype of female sterility, meiosis II arrest, and egg activation defects." FBgn0050291 UniProtKB "Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy). (UniProtKB:Q95SK3)" FBgn0034569 UniProtKB "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). (UniProtKB:Q9W2P0)" FBgn0034568 Alliance Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon. FBgn0034567 Alliance Predicted to be involved in protein O-linked mannosylation. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in Golgi apparatus. Is expressed in adult head; embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and muscular dystrophy (multiple). Orthologous to human FKRP (fukutin related protein). FBgn0008636 Interactive Fly "Paired-like homeobox transcription factor - mutants are embryonic lethal and characterized by a reduction in the anterior protocerebrum, including the mushroom bodies, and a loss of the supraoesophageal brain commissure - in larvae expressed in all type II lineages and the optic lobes including the medulla and lobula plug - mutants are characterized by a reduction of the protocerebrum, a loss of the supraesophageal commissure and mushroom body progenitors and also by a dislocation of the optic lobes - Homeobrain define middle-aged and late intermediate neural progenitor temporal windows and play a role in cellular longevity - Homeobrain has conserved functions as temporal factors in the developing visual system" FBgn0015524 FlyBase Gene Snapshot "orthopedia (otp) encodes a homeodomain transcription factor expressed in the hindgut and nervous system. otp mutant alleles show a severe hindgut phenotype in the embryo, with a complete loss of the large intestine and a reduction of the anal pads due to apoptosis, leading to embryonic lethality." FBgn0040653 FlyBase Gene Snapshot "Daisho1 (Dso1) encodes an immune effector peptide regulated by Toll NF-kappaB signalling. Mutant flies are susceptible to fungal infection, and Dso1 shows binding to fungal hyphae ex vivo." FBgn0034553 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in anal pad primordium; embryonic anal pad; and hindgut proper primordium. FBgn0034552 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in embryonic anal pad. FBgn0011674 FlyBase Gene Snapshot "inscuteable (insc) encodes an adaptor protein required for asymmetric cell division. It interacts with the microtubule binding protein encoded by mud and the adaptor encoded by pins. It also binds to the apical complex proteins encoded by baz, par-6 and aPKC and may recruit microtubule binding proteins to the apical cell cortex to induce apical-basal spindle orientation." FBgn0016984 FlyBase Gene Snapshot "skittles (sktl) encodes the major Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K), catalysing the formation of phosphoinositol-4,5-bisphosphate (PIP4,5). The sktl product is involved in many cellular processes involving (PIP4,5), such as endocytosis. It plays an important role in cell polarity by controlling the localization of the product encoded by baz." FBgn0034588 Alliance Predicted to enable glycerophosphocholine phosphodiesterase activity. Predicted to be involved in glycerophospholipid catabolic process. Is expressed in adult head; embryonic midgut chamber; and embryonic/larval midgut. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1). FBgn0002736 FlyBase Gene Snapshot "mago nashi (mago) encodes a protein that is part of the exon junction complex, which is required for post-transcriptional processes such as pre-mRNA splicing, RNA localization and nonsense-mediated decay. It is involved in germline development, germplasm assembly and photoreceptor differentiation." FBgn0034592 Alliance Predicted to enable calcium ion binding activity. Is expressed in spermatozoon. Orthologous to human EFCAB2 (EF-hand calcium binding domain 2). FBgn0021872 FlyBase Gene Snapshot "X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development." FBgn0026582 FlyBase Gene Snapshot "High mobility group protein 2 (Hmg-2) encodes a member of the non-histone chromosomal high-mobility group protein family. These proteins associate with with chromatin and are ubiquitously distributed in the nucleus of eukaryotic cells. The product of Hmg-2 binds to DNA in a non-sequence specific fashion to induce structural changes in DNA that include bending and unwinding that in turn, promote DNA flexibility." FBgn0050208 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034599 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism; wing disc; and wing hinge. FBgn0003162 UniProtKB "Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. (UniProtKB:P48596)" FBgn0011872 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003891 UniProtKB "May act via the Piwi-interacting RNA (piRNA) metabolic process mediated by aub and AGO3 Piwi proteins, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:19959991). Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation (PubMed:17428915). Not involved in repression of retroelements (PubMed:17428915). (UniProtKB:P25823)" FBgn0034602 FlyBase Gene Snapshot Leucine-rich repeat activity-regulated protein at synapses (Lapsyn) encodes a member of the leucine-rich repeat (LRR) family of cell surface protein. It is expressed in glial cells and required for branch morphogenesis of astrocyte-like glia in the visual system and other areas of the central nervous system during larval and pupal development. FBgn0034611 FlyBase Gene Snapshot Major Facilitator Superfamily Transporter 16 (MFS16) encodes a putative transmembrane transporter that transports glucose-6-phosphate into the reticulum endoplasmic in the last step of gluconeogenesis. FBgn0016726 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and organism. Orthologous to human RPL29 (ribosomal protein L29). FBgn0020306 FlyBase Gene Snapshot "domino (dom) encodes a protein of the SWI2/SNF2 class of DNA-dependent ATPases. It is a component of the Tip60 acetyltransferase complex and functions in the exchange of histone His2Av. dom product contributes to Notch signaling and cell death regulation, as well as numerous other processes." FBgn0034622 Alliance Predicted to be involved in cilium assembly. Predicted to be part of BBSome. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 9; craniosynostosis; and primary ovarian insufficiency. Orthologous to human BBS9 (Bardet-Biedl syndrome 9). FBgn0034628 Alliance Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be active in peroxisome. Is expressed in adult head; adult heart; embryonic Malpighian tubule; and organism. Human ortholog(s) of this gene implicated in Mitchell syndrome; congenital bile acid synthesis defect 6; and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1). FBgn0034629 Alliance Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be active in peroxisome. Is expressed in adult head; embryonic dorsal epidermis; embryonic small intestine; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in Mitchell syndrome; congenital bile acid synthesis defect 6; and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1). FBgn0034627 FlyBase Gene Snapshot "eukaryotic translation elongation factor, selenocysteine-specific (eEFSec) encodes a protein involved in the incorporation of selenocysteine during protein translation." FBgn0034626 UniProtKB Positive regulator of Notch signaling (PubMed:34905536). Maternal neurogenic factor involved in Notch signaling-dependent neuroectodermal specification during early embryogenesis (PubMed:34905536). Functions cooperatively with amx/TM2D3 and amrt/TM2D2 (PubMed:34905536). (UniProtKB:Q9W2H1) FBgn0000395 FlyBase Gene Snapshot "crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo." FBgn0034624 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0034623 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0050394 Alliance "Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic proventriculus; embryonic proventriculus inner layer; embryonic/larval garland cell; and gland. Orthologous to human SLC38A10 (solute carrier family 38 member 10)." FBgn0034617 FlyBase Gene Snapshot "Panoramix (Panx) encodes a nuclear protein with an essential role in piRNA-guided transcriptional silencing, interacting directly or indirectly with the product of piwi. It is required for fertility." FBgn0034614 Alliance Predicted to be involved in tRNA-guanine transglycosylation. Orthologous to human QNG1 (Q-nucleotide N-glycosylase 1). FBgn0050390 FlyBase Gene Snapshot SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes. FBgn0050392 Alliance Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to several human genes including CPTP (ceramide-1-phosphate transfer protein). FBgn0034612 FlyBase Gene Snapshot "CG10505 encodes an ABC transporter whose expression is induced by excess copper, zinc, and cadmium. It is a target of the metal-responsive transcription factor encoded by MTF-1." FBgn0034606 FlyBase Gene Snapshot "Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (ASPP) encodes a scaffold protein localised at the adherens junctions (AJ) of epithelial cells. It promotes AJ stability by repressing Src activity via the kinase encoded by Csk." FBgn0034605 Alliance Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Orthologous to several human genes including UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). FBgn0027073 Alliance Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in endoplasmic reticulum. Is expressed in adult head and adult heart. Orthologous to several human genes including UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). FBgn0050209 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034601 Alliance Is expressed in spermatozoon. FBgn0034598 Alliance Enables chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II. Part of chromatin. Is expressed in larval ventral nerve cord and organism. Orthologous to human SCAF4 (SR-related CTD associated factor 4) and SCAF8 (SR-related CTD associated factor 8). FBgn0011871 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050206 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050389 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). FBgn0034590 FlyBase Gene Snapshot Magi (Magi) encodes a molecular scaffolding protein that is involved in adherens junction (AJ) organization. Magi is ubiquitously expressed and its product localizes at AJ with the Par polarity complex. FBgn0020312 UniProtKB Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (UniProtKB:Q7K4B6) FBgn0011824 UniProtKB "Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (UniProtKB:Q7KVQ0)" FBgn0034585 FlyBase Gene Snapshot Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size. FBgn0026369 FlyBase Gene Snapshot "Smad anchor for receptor activation (Sara) encodes an endosomal protein involved in asymmetric stem cell division, intestinal stem cell homeostasis and stem cell fate determination." FBgn0003731 FlyBase Gene Snapshot "Epidermal growth factor receptor (Egfr) encodes the transmembrane tyrosine kinase receptor for signaling ligands (encoded by grk, spi, vn, and Krn) in the TGFalpha family, which utilises the intracellular MAP kinase pathway. The product of Egfr contributes to growth regulation, cell survival and developmental patterning." FBgn0053225 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0034641 FlyBase Gene Snapshot "mahjong (mahj) encodes a protein involved in regulation of cell cycle, proliferation and cellular fitness. Epithelial cells lacking mahj function are out competed by their wild type neighbors." FBgn0034643 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in organism. FBgn0034644 Alliance "Predicted to enable inositol hexakisphosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including amnioserosa; ganglia; glial cell; gut section; and hypodermal muscle cell of A1-7. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1); IP6K2 (inositol hexakisphosphate kinase 2); and IP6K3 (inositol hexakisphosphate kinase 3)." FBgn0034645 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 25. Orthologous to human NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3). FBgn0034650 FlyBase Gene Snapshot "Negative Cofactor 2alpha (NC2alpha) encodes a protein that, together with the product of NC2beta forms the negative cofactor 2 complex (NC2), which represses transcription from TATA box-dependent core promoters and activates transcription from DPE-dependent core promoters." FBgn0034651 Alliance Predicted to enable tubulin binding activity. Predicted to be involved in microtubule-based process and tubulin complex assembly. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. FBgn0050263 UniProtKB Required for locomotion and mechanical sensing in proprioceptive neurons by transducing dendrite stretching into cellular responses. Required for transduction of mechanical stimuli in a specific subpopulation of proprioceptive neurons that sense joint angles. Probably does not constitute the mechanically activated channel and may rather serve as an accessory module required for the proper localization or function of the transduction channels. (UniProtKB:Q9W2E1) FBgn0034654 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q9W2D9)" FBgn0034655 Alliance Predicted to be involved in signal transduction. FBgn0050290 Alliance Predicted to enable FMN binding activity and phosphopantothenoylcysteine decarboxylase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be part of phosphopantothenoylcysteine decarboxylase complex. Is expressed in organism. Used to study neurodegeneration with brain iron accumulation. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). FBgn0010228 Alliance "Predicted to enable transcription cis-regulatory region binding activity. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; ganglia; and ventral nerve cord primordium." FBgn0027360 UniProtKB Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). (UniProtKB:Q9W2D6) FBgn0050285 Alliance Involved in nervous system process. Predicted to be located in membrane. FBgn0034649 Alliance "Predicted to enable mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Predicted to be part of glycosylphosphatidylinositol-mannosyltransferase I complex. Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval fat body; eye disc; and larval ventral nerve cord. Orthologous to human PIGM (phosphatidylinositol glycan anchor biosynthesis class M)." FBgn0034647 FlyBase Gene Snapshot "poor Imd response upon knock-in (pirk) encodes a negative regulator of the immune deficiency (Imd) pathway, acting at the level of the product of PGRP-LC. Being regulated by the Imd pathway itself, it establishes a negative feedback loop adjusting Imd pathway activity to the severity of infection." FBgn0034646 FlyBase Gene Snapshot "Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation." FBgn0050284 Alliance Predicted to enable sterol binding activity and sterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1C (GRAM domain containing 1C). FBgn0016641 FlyBase Gene Snapshot Protein tyrosine phosphatase-ERK/Enhancer of Ras1 (PTP-ER) encodes a phosphatase required for mitosis. It is involved in RAS/MAPK signaling regulation and eye development. FBgn0000326 Alliance Enables serine hydrolase activity. Involved in male mating behavior. Is expressed in organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES5A (carboxylesterase 5A). FBgn0034638 Alliance Involved in regulation of female receptivity. Located in extracellular space. Is expressed in amnioserosa; embryonic proventriculus; embryonic/larval salivary gland; embryonic/larval salivary gland body; and yolk nucleus. FBgn0034636 UniProtKB "Functions with the transcription factor TfAP-2 to regulate octopamine neuronal signaling pathways that control behaviors such as male aggression, male mating, and the initiation of feeding (PubMed:24142897, PubMed:25187989, PubMed:30231996). Required for TfAP-2 transcriptional activity in octopaminergic neurons (PubMed:24142897, PubMed:25187989). Functions with TfAP-2 to regulate expression of genes which are involved in promoting octopamine production and secretion from octopaminergic neurons, such as Tbh and Vmat (PubMed:24142897, PubMed:25187989). Octopamine then modulates feeding and male aggression by regulating the expression of the satiation hormone Dsk in insulin-producing cells (IPCs) (PubMed:24142897, PubMed:25187989). Functions with octopamine and Dsk as part of a negative feedback loop to prevent overeating; acts with TfAP-2 to regulate octopamine signaling pathways that initiate feeding, then octopamine activates expression of Dsk which inhibits consummatory behavior (PubMed:25187989). May also be involved in negatively regulating nociception in larvae to prevent spontaneous pain and hyperalgesia (PubMed:30231996). (UniProtKB:D5SHR0)" FBgn0260477 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0069056 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0050287 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0050286 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0050289 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0050288 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0034634 Alliance Is expressed in organism. FBgn0034631 Alliance Predicted to be involved in nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase transcription factor SL1 complex. FBgn0010470 FlyBase Gene Snapshot "FK506-binding protein 14 (Fkbp14) encodes an ER resident protein and a member of the large FKBP family of immunophilins. It plays an essential role in development, including stabilizing the protein encoded by Psn in the ER. Fkbp14 mutants genetically interact with components of the Notch pathway." FBgn0010415 FlyBase Gene Snapshot "Syndecan (Sdc) encodes a transmembrane heparan sulfate proteoglycan. It binds to the products of sli and robo1 to regulate axon guidance at the CNS midline, and it cooperates with the product of Lar to promote synapse growth at the larval neuromuscular junction." FBgn0004362 FlyBase Gene Snapshot High mobility group protein D (HmgD) encodes a highly abundant chromosomal protein involved in DNA bending and chromatin organization. FBgn0050398 Alliance Orthologous to human MITD1 (microtubule interacting and trafficking domain containing 1). FBgn0034657 UniProtKB Anchors the lamina and the heterochromatin to the inner nuclear membrane. (UniProtKB:Q8MLV1) FBgn0034658 Alliance Predicted to enable glutathione disulfide oxidoreductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be active in cytoplasm. Orthologous to human GLRX2 (glutaredoxin 2). FBgn0050395 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0034659 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in adult head. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3)." FBgn0034666 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0034674 Alliance Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Is expressed in adult head. Orthologous to human TMEM145 (transmembrane protein 145). FBgn0041237 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9W2B2)" FBgn0041239 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58962)" FBgn0050401 FlyBase Gene Snapshot "distal antenna-young (dany) encodes a chromatin-binding protein required in spermatocytes for a normal gene expression profile, meiosis and sperm production." FBgn0041238 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9W2B1)" FBgn0025573 Alliance Predicted to enable protein serine/threonine phosphatase activity. Located in nucleus. Is expressed in testis. FBgn0034667 FlyBase Gene Snapshot cookie monster (comr) encodes a protein involved in spermatogenesis and transcription regulation. FBgn0050406 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050407 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034665 Alliance Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). FBgn0034664 Alliance Is expressed in adult head. FBgn0034662 Alliance Is expressed in adult head. FBgn0034661 Alliance "Predicted to enable serine-type endopeptidase activity. Involved in liquid clearance, open tracheal system. Predicted to be active in extracellular space. Is expressed in embryonic/larval dorsal tracheal branch; embryonic/larval tracheal dorsal trunk; and embryonic/larval visceral tracheal branch." FBgn0042098 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0034660 Alliance Predicted to enable protein-lysine 6-oxidase activity. Predicted to be involved in protein modification process. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in organism. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; myopia; and primary open angle glaucoma. Orthologous to several human genes including LOXL3 (lysyl oxidase like 3). FBgn0050404 UniProtKB May play a role in mitochondrial and peroxisomal fission. (UniProtKB:Q961C9) FBgn0050403 Alliance Predicted to enable DNA binding activity. Is expressed in embryonic brain; gonad; larval ventral nerve cord; and organism. FBgn0034681 Alliance "Predicted to enable cargo receptor activity. Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including adult brain; adult fat body; adult head; adult ventral nerve cord; and gland." FBgn0067102 FlyBase Gene Snapshot "Glucosylceramide synthase (GlcT) encodes an enzyme that catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. It regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development." FBgn0034691 FlyBase Gene Snapshot "Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle." FBgn0034694 Alliance Enables small GTPase binding activity. Involved in vesicle fusion. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6 and osteopetrosis. Orthologous to several human genes including PLEKHM1 (pleckstrin homology and RUN domain containing M1). FBgn0050281 Alliance Predicted to enable G protein-coupled receptor binding activity and chitin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to several human genes including MFAP4 (microfibril associated protein 4). FBgn0002715 FlyBase Gene Snapshot meiotic from via Salaria 332 (mei-S332) encodes the founding member of the Shugoshin protein family and is required for retention of centromere cohesion in both male and female meiosis I. FBgn0029147 Alliance "Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic head sensory system; gnathal primordium; and labral sensory complex primordium." FBgn0034700 Alliance Predicted to enable RNA endonuclease activity. FBgn0029084 FlyBase Gene Snapshot "gomdanji (gom) encodes a calcium ion binding protein involved in calcium-mediated signaling, courtship behavior and learning." FBgn0034704 Alliance Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of synaptonemal complex assembly. Part of SCF ubiquitin ligase complex. Orthologous to human FBXO42 (F-box protein 42). FBgn0034706 Alliance "Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult fat body; antennal primordium; clypeo-labral primordium; gut section; and head epidermis primordium." FBgn0034707 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. Required for transcriptional activation in response to lipopolysacchardie (LPS). (UniProtKB:Q9W278)" FBgn0034708 FlyBase Gene Snapshot Vacuolar protein sorting 35 (Vps35) encodes a component of the retromer complex that acts to recycle membrane proteins to the Golgi or plasma membrane from endocytosed vesicles. FBgn0034713 Alliance Predicted to enable phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in organism; ring gland; and spermatozoon. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). FBgn0025186 UniProtKB "Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. (UniProtKB:O76924)" FBgn0020307 FlyBase Gene Snapshot "defective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation." FBgn0034716 FlyBase Gene Snapshot "Organic anion transporting polypeptide 58Dc (Oatp58Dc) encodes a membrane transporter implicated in renal elimination of organic compounds including ouabain and methotrexate. In the perineural glia of the blood brain barrier, the product of Oatp58Dc protects the brain from potentially toxic organic anions in the hemolymph." FBgn0034715 Alliance Enables active transmembrane transporter activity. Involved in renal tubular secretion. Located in basolateral plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder; gastrointestinal stromal tumor; and primary hypertrophic osteoarthropathy. Orthologous to several human genes including SLCO1A2 (solute carrier organic anion transporter family member 1A2); SLCO1B1 (solute carrier organic anion transporter family member 1B1); and SLCO1B3 (solute carrier organic anion transporter family member 1B3). FBgn0050277 Alliance Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder; gastrointestinal stromal tumor; and primary hypertrophic osteoarthropathy. Orthologous to several human genes including SLCO1A2 (solute carrier organic anion transporter family member 1A2); SLCO1B1 (solute carrier organic anion transporter family member 1B1); and SLCO1B3 (solute carrier organic anion transporter family member 1B3). FBgn0050278 Alliance Is expressed in spermatozoon. FBgn0034712 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0034710 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0034709 FlyBase Gene Snapshot Secreted Wg-interacting molecule (Swim) encodes a secreted protein that binds to the product of wg and may function in its spreading. FBgn0034705 Alliance Is expressed in adult head. Orthologous to several human genes including DIPK2A (divergent protein kinase domain 2A). FBgn0034703 Alliance Predicted to enable tRNA pseudouridine(38/39) synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Orthologous to human PUS3 (pseudouridine synthase 3). FBgn0034697 FlyBase Gene Snapshot Golgi matrix protein 130 kD (GM130) encodes a protein involved in Golgi compartmental organization and regulation of dendrite morphogenesis. FBgn0034692 Alliance Predicted to be involved in cilium assembly and cilium movement. Predicted to be located in axoneme. Is expressed in chordotonal neurons. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). FBgn0034689 Alliance Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in DNA damage response. Is expressed in organism. Orthologous to human ARMT1 (acidic residue methyltransferase 1). FBgn0034688 Alliance Predicted to enable phosphatase activity. Predicted to be involved in DNA damage response. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and organism. Orthologous to human ARMT1 (acidic residue methyltransferase 1). FBgn0034687 Alliance Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in DNA damage response. Orthologous to human ARMT1 (acidic residue methyltransferase 1). FBgn0034684 Alliance Is expressed in spermatogonium and spermatozoon. FBgn0034683 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0005778 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including amnioserosa; embryonic/larval nervous system; larval ventral nerve cord; lateral cord; and testis." FBgn0034717 Alliance "Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and proventriculus primordium." FBgn0013272 FlyBase Gene Snapshot Gp150 (Gp150) encodes a transmembrane glycoprotein that regulates Notch signaling and is involved in eye development. FBgn0016053 FlyBase Gene Snapshot polar granule component (pgc) encodes a small polypeptide involved in transcriptional silencing in primordial germ cells and in germ cell specification. It interacts with the RpII215/Spn43Ab complex that regulates RNA polymerase II expression. FBgn0034721 Alliance Predicted to be involved in regulation of microtubule polymerization or depolymerization. FBgn0034722 FlyBase Gene Snapshot Rtf1 (Rtf1) encodes a transcription elongation factor that acts downstream of the products of Ubc6 and Bre1 in regulating the histone modification activity of the Set1/COMPASS complex. It regulates Notch signaling. FBgn0025878 FlyBase Gene Snapshot wrapper (wrapper) encodes a protein involved in axon ensheathment and glial apoptosis. FBgn0034723 Alliance "Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic epipharynx; embryonic hypopharynx; and gut section." FBgn0034725 Alliance Is expressed in ganglia; larval midline neurons; larval ventral midline glial cell; lateral cord neurons; and ventral midline of embryo. FBgn0053200 Alliance Is expressed in mesoderm and mesoderm anlage. FBgn0034726 FlyBase Gene Snapshot "DNA polymerase epsilon subunit 4 (PolE4) encodes an accessory, non-catalytic subunit of the major replicative polymerase epsilon. It is one of the maternal target genes of the transcription factor encoded by dl and is regulated by the DRE/DREF pathway." FBgn0022985 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in adult head; germline cell; and organism. Orthologous to human KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1) and KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2)." FBgn0034728 FlyBase Gene Snapshot rad50 (rad50) encodes a protein belonging to the SMC family and RAD50 subfamily that is involved in DNA repair. It is required for double-strand break repair and telomere maintenance. FBgn0034730 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval tracheal dorsal trunk and tracheal tip cell. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). FBgn0034731 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3)." FBgn0034733 Alliance "Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval circulatory system; embryonic/larval dorsal vessel; epithelium; and gut section. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing)." FBgn0034734 Alliance Predicted to be part of 90S preribosome and small-subunit processome. Predicted to be active in nucleolus. Orthologous to human UTP20 (UTP20 small subunit processome component). FBgn0034735 Alliance Predicted to enable flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). FBgn0034736 Alliance Enables serine hydrolase activity. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0003175 FlyBase Gene Snapshot plexus (px) encodes a ubiquitously expressed nuclear matrix protein required to restrict excess wing vein development by repressing transcription of the pro-vein gene rho. FBgn0034729 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in embryonic/larval central nervous system and organism. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0034727 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrial ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle system; gastric caecum; and gut section. Orthologous to human DAP3 (death associated protein 3)." FBgn0022986 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult brain cell body rind; adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2)." FBgn0022984 FlyBase Gene Snapshot quaking related 58E-3 (qkr58E-3) encodes an RNA binding protein that contributes to mRNA splicing and apoptosis. FBgn0034724 FlyBase Gene Snapshot "babos (babos) encodes a cell surface protein that belongs to the group of immunoglobulin superfamily cell adhesion molecules. If functions in learning and memory, as well as in developmental dendrite plasticity." FBgn0034720 FlyBase Gene Snapshot "Liprin-gamma (Liprin-gamma) encodes an adaptor protein that counteracts the functions of the product of Liprin-alpha in photoreceptor axon targeting and the product of Liprin-beta in neuromuscular junction development, potentially through competition for binding partners." FBgn0017482 UniProtKB "Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). (UniProtKB:Q9W265)" FBgn0034718 FlyBase Gene Snapshot "windpipe (wdp) encodes a regulator of the JAK/STAT pathway. It is involved in intestinal homeostasis, trachea development and synaptic target recognition." FBgn0034739 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3)." FBgn0034743 Alliance "A structural constituent of ribosome. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPS16 (ribosomal protein S16)." FBgn0034744 FlyBase Gene Snapshot "Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis." FBgn0053143 Alliance Involved in positive regulation of macroautophagy. Is expressed in spermatozoon. FBgn0026261 FlyBase Gene Snapshot bonsai (bonsai) encodes a mitochondrial small ribosomal protein that belongs to the universal S15 ribosomal protein US15m family. It is involved in growth regulation. FBgn0034740 Alliance "Predicted to enable mRNA binding activity. Involved in post-transcriptional regulation of gene expression; sperm axoneme assembly; and sperm individualization. Located in nuclear speck. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3)." FBgn0034758 Alliance Predicted to enable zinc ion binding activity. Involved in cold acclimation. Is expressed in adult head. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor). FBgn0034759 Alliance Predicted to enable zinc ion binding activity. FBgn0034761 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in cytoplasmic side of endosome membrane. Is expressed in wing hinge primordium and wing pouch. FBgn0050273 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in cytoplasmic side of membrane. FBgn0050269 Alliance Predicted to enable zinc ion binding activity. Is expressed in embryonic Malpighian tubule; embryonic hindgut; and embryonic/larval midgut. FBgn0034763 FlyBase Gene Snapshot "Ring and YY1 Binding Protein (RYBP) encodes a ubiquitin interacting protein. It interacts with epigenetic regulators of the Polycomb and trithorax groups to control post-translational histone modifications. The product of RYBP is involved in regulation of the innate immune response and cell death/cell survival, and the control of morphogenesis." FBgn0034766 UniProtKB Odorant-binding protein required for hygrotaxis behavior in humidity-detecting sensilla. (UniProtKB:Q86BF9) FBgn0034768 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0034770 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0050275 Alliance Predicted to enable oxidoreductase activity. Is expressed in spermatogonium. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human CFAP61 (cilia and flagella associated protein 61). FBgn0050268 Alliance Is expressed in spermatogonium. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human CFAP61 (cilia and flagella associated protein 61). FBgn0034774 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. Orthologous to human CABP4 (calcium binding protein 4). FBgn0034776 Alliance Predicted to be involved in proteolysis. FBgn0011211 FlyBase Gene Snapshot "bellwether (blw) encodes the alpha subunit of the mitochondrial F1F0 ATP synthase complex (complex V), the final enzyme of the oxidative phosphorylation pathway. Complex V catalyzes the synthesis of ATP from ADP and inorganic phosphate using the electrochemical proton gradient across the inner mitochondrial membrane." FBgn0050271 Alliance Is expressed in embryonic head sensory system and labral sensory complex. FBgn0050274 Alliance Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to be active in extracellular space. FBgn0050272 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in adult head. FBgn0050265 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in yolk nucleus. FBgn0034782 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. FBgn0034783 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4). FBgn0034784 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. FBgn0034785 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4). FBgn0010078 Alliance Enables myosin binding activity. A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Orthologous to human RPL23 (ribosomal protein L23). FBgn0004896 FlyBase Gene Snapshot forkhead domain 59A (fd59A) encodes a transcription factor that is expressed largely in postmitotic neurons in the central nervous system. Its roles include nervous system development and egg-laying behavior. FBgn0034788 Alliance Predicted to be located in extracellular region. Is expressed in embryonic head sensory system; ganglia; larval midline neurons; sensory nervous system primordium; and ventral midline of embryo. FBgn0034789 FlyBase Gene Snapshot "Phosphatidylinositol 4-phosphate 5-kinase at 59B (PIP5K59B) encodes a lipid kinase enzyme that mediates the synthesis of the lipid phosphatidylinositol 4,5 bisphosphate (PIP2) during phospholipase C signalling." FBgn0034793 FlyBase Gene Snapshot "asrij (asrij) encodes a conserved ovarian carcinoma immunoreactive antigen domain-containing endosomal protein that maintains stemness. It positively regulates JAK/STAT signalling and negatively regulates the Notch pathway. It interacts with the GTP-bound form of the product of Arf1 to regulate hematopoiesis and immunity, and regulates mitochondrial dynamics through functional interactions with Drp1 and Marf." FBgn0034795 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for transcriptional activation in response to heat shock. (UniProtKB:Q9W1X7)" FBgn0034796 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0034792 FlyBase Gene Snapshot "YME1 like ATPase (YME1L) encodes an AAA protease localized at the mitochondrial inner membrane. It is involved in mitochondrial quality control and its loss causes male sterility, premature aging, and neuromuscular degenerative phenotypes." FBgn0034791 FlyBase Gene Snapshot "ER Membrane protein Complex 8-9 (EMC8-9) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins." FBgn0001263 FlyBase Gene Snapshot "inactivation no afterpotential D (inaD) encodes a scaffolding protein that functions in the localization of the signaling proteins encoded by trp, inaC, and norpA to the rhabdomere. It also functions in the fast light-induced signaling of photoreceptors." FBgn0034786 Alliance "Predicted to be involved in several processes, including axo-dendritic transport; axon extension; and synaptic vesicle transport. Predicted to be active in several cellular components, including axon; dendrite; and synapse. Is expressed in adult head. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2X; amyotrophic lateral sclerosis type 5; and hereditary spastic paraplegia 11. Orthologous to human SPG11 (SPG11 vesicle trafficking associated, spatacsin)." FBgn0000405 FlyBase Gene Snapshot "Cyclin B (CycB) encodes a protein that binds to Cdk1, thereby promoting Cdk1's protein kinase activity. The complex CycB-Cdk1 complex induces the start of mitosis. During late metaphase of mitosis and continuing in G1, the product of CycB is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity, and allowing termination of mitosis." FBgn0034769 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0050259 Alliance Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in chordotonal neurons and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65). FBgn0005631 FlyBase Gene Snapshot roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development. FBgn0020257 FlyBase Gene Snapshot Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. FBgn0050196 Alliance Predicted to enable zinc ion binding activity. FBgn0034756 FlyBase Gene Snapshot Cyp6d2 (Cyp6d2) encodes a member of the cytochrome P450 oxidase protein family and is involved in the detoxification of toxic compounds. Two common Cyp6d2 alleles found in many Dmel stocks result in extreme sensitivity to camptothecin. FBgn0050195 Alliance Predicted to enable zinc ion binding activity. FBgn0034753 Alliance Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Orthologous to several human genes including PPIB (peptidylprolyl isomerase B). FBgn0040091 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in several structures, including adult head; cephalic vascular primordium; circulatory system primordium; embryonic/larval hemocyte; and visceral mesoderm derivative." FBgn0034750 Alliance "Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in RNA processing. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human ZRANB2 (zinc finger RANBP2-type containing 2)." FBgn0019949 FlyBase Gene Snapshot "Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control." FBgn0034748 Alliance "Predicted to enable tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity and tRNA binding activity. Involved in tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 71. Orthologous to human ALKBH8 (alkB homolog 8, tRNA methyltransferase)." FBgn0034745 FlyBase Gene Snapshot "testes of unusual size (tous) encodes a protein involved in ciliogenesis, and is required for proper cytokinesis during male meiosis. When mutated, it results in male sterility with decreased fitness, immotile flagella, irregular testis morphology, and disrupted localization of subcellular structures during spermatogenesis." FBgn0034742 Alliance Is expressed in organism; pole plasm; posterior endoderm; and primordial germ cell. FBgn0034797 Alliance "Is expressed in several structures, including adult head; centripetal follicle cell; dorsal epidermis primordium; egg chamber; and embryonic anal pad." FBgn0034803 UniProtKB May be involved in iversification of muscle cell fates. (UniProtKB:Q9W1W9) FBgn0021979 Alliance "Enables serine hydrolase activity. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm." FBgn0050202 Alliance Predicted to enable UCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034816 Alliance "Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cilium assembly; cilium movement involved in cell motility; and microtubule nucleation. Predicted to be active in microtubule cytoskeleton. Is expressed in several structures, including chordotonal neurons; embryonic head sensory system; male germline cell; and sensory nervous system primordium. Orthologous to human TEKT2 (tektin 2)." FBgn0045483 Alliance "Predicted to enable ligand-gated monoatomic ion channel activity and sweet taste receptor activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in adult labellum sensillum; labellum; larval gnathal ganglion; organism subdivision; and sensory neurons." FBgn0045482 Alliance "Predicted to enable ligand-gated monoatomic ion channel activity and sweet taste receptor activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in adult labellum sensillum; gnathal ganglion; gustatory receptor neurons; labellum; and organism subdivision." FBgn0034827 FlyBase Gene Snapshot Kinesin-like protein at 59D (Klp59D) encodes a kinesin involved in the regulation spindle microtubule dynamics and sperm ciliogenesis. FBgn0034829 Alliance Predicted to enable RNA polymerase II complex binding activity and SH2 domain binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and transcription elongation by RNA polymerase II. Predicted to be part of Cdc73/Paf1 complex and euchromatin. FBgn0034826 Alliance Predicted to enable calmodulin binding activity. Predicted to be involved in establishment of meiotic spindle localization; mitotic cell cycle; and spindle organization. Predicted to be active in spindle pole. Orthologous to human SPATA17 (spermatogenesis associated 17). FBgn0034825 Alliance Predicted to enable NAD binding activity and protein homodimerization activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase (FAD) complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). FBgn0034824 UniProtKB "Required during anaphase to drive sister chromatid separation to actively depolymerize kinetochore microtubules at their kinetochore-associated plus ends, thereby contributing to chromatid mobility through a 'Pac-man' mechanism. (UniProtKB:Q9W1U4)" FBgn0041236 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58985)" FBgn0041235 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9W1U5)" FBgn0034822 UniProtKB Binds to the 23S rRNA. (UniProtKB:Q9W1U6) FBgn0034821 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in embryonic/larval oenocyte; embryonic/larval posterior spiracle; oenocyte primordium; prothoracic gland; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to several human genes including PRRX1 (paired related homeobox 1)." FBgn0034817 UniProtKB Essential arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3. (UniProtKB:Q9W1V1) FBgn0003062 FlyBase Gene Snapshot Fibrillarin (Fib) encodes an rRNA 2'-O-methyltransferase required for pre-rRNA processing. FBgn0050201 Alliance Predicted to enable UCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034814 UniProtKB "DNA binding protein which is involved in the positive regulation of both basal and inducible transcription (PubMed:33456983). Mainly localizes to active promoter sites and interacts with components of various transcription and replication regulatory complexes, such as the ORC, SAGA, THO, TFIID and SWI/SNF complexes (PubMed:30713769, PubMed:33456983). It may therefore regulate transcription by promoting the association of these complexes to their binding sites (PubMed:30713769, PubMed:33456983). (UniProtKB:Q9W1V7)" FBgn0010622 Alliance Involved in regulation of hemocyte proliferation. Predicted to be part of dynactin complex. Is expressed in organism. Orthologous to human DCTN3 (dynactin subunit 3). FBgn0034808 Alliance Is expressed in organism. FBgn0034807 Alliance Predicted to be involved in proteolysis. Is expressed in female reproductive system and seminal receptacle. FBgn0052833 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and male reproductive system. FBgn0052834 Alliance Predicted to be involved in proteolysis. Is expressed in female reproductive system and spermatheca. FBgn0034804 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in embryonic/larval corpus allatum and organism. FBgn0034802 UniProtKB "Single-stranded DNA/RNA-binding protein with sequence specificity (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity). IRES trans-acting factor (ITAF) that can promote IRES-dependent translation of Myc mRNA (PubMed:24275942). Involved in the control of wing size by regulating Myc levels (PubMed:24275942). (UniProtKB:Q8T8R1)" FBgn0034800 Alliance Predicted to enable uridine phosphorylase activity. Predicted to be involved in uridine catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to human UPP1 (uridine phosphorylase 1) and UPP2 (uridine phosphorylase 2). FBgn0010660 UniProtKB "Part of the nuclear pore complex (PubMed:14638854). Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad (PubMed:17032737, PubMed:17682050, PubMed:20547758). Protects mbo/Nup88 from proteasomal degradation at the nuclear pore (PubMed:17032737). Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export (PubMed:17032737). Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response (PubMed:17032737). (UniProtKB:Q9W1X4)" FBgn0050187 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0034835 Alliance Predicted to enable ribosome binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane from matrix. Predicted to be active in mitochondrial inner membrane. FBgn0034841 FlyBase Gene Snapshot atlas (atlas) encodes a newly evolved protein that is required for the condensation of chromatin in the nuclei of developing sperm cells. FBgn0034846 Alliance Predicted to enable ribosome binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane from matrix. Predicted to be active in mitochondrial inner membrane. FBgn0050410 FlyBase Gene Snapshot Ribose-5-phosphate isomerase (Rpi) encodes an enzyme that catalyzes the reversible conversion of D-ribulose 5-phosphate to D-ribose-5-phosphate. It is involved in the non-oxidative branch of the pentose phosphate pathway. FBgn0034853 UniProtKB "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). (UniProtKB:Q9W1R4)" FBgn0041712 Alliance Predicted to be active in extracellular region. FBgn0034856 Alliance Predicted to be active in extracellular region. FBgn0034858 Alliance "Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic/larval midgut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)." FBgn0034866 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:Q9W1P7)" FBgn0034865 FlyBase Gene Snapshot Odorant receptor 59b (Or59b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0034863 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). FBgn0026384 FlyBase Gene Snapshot Odorant receptor 59a (Or59a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0034860 Alliance Is expressed in adult head; embryonic/larval tracheal dorsal trunk; and embryonic/larval visceral tracheal branch. FBgn0034859 Alliance Predicted to be involved in regulation of post-transcriptional gene silencing. Is expressed in organism. Orthologous to human FOCAD (focadhesin). FBgn0028497 Alliance "Predicted to enable phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Involved in mitotic cell cycle and regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8)." FBgn0050414 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0040660 Alliance "Predicted to enable ATPase binding activity and ATPase inhibitor activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic anal pad; embryonic large intestine; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1)." FBgn0034854 Alliance Enables small GTPase binding activity. Predicted to be involved in Golgi vesicle transport. Located in Golgi trans cisterna. Is active in trans-Golgi network membrane. Is expressed in adult head and spermatozoon. Orthologous to human GOLGA4 (golgin A4). FBgn0003977 UniProtKB "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:11156988, PubMed:27919077). M6A methylation is also required for neuronal functions (PubMed:27919077). Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b (PubMed:10101174). (UniProtKB:Q9W1R5)" FBgn0034849 Alliance Predicted to enable COPII receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human TEX261 (testis expressed 261). FBgn0046253 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. FBgn0050417 FlyBase Gene Snapshot "testis-specifically expressed bromodomain containing protein-3 (tbrd-3) encodes a protein that interacts with the products of tbrd-1, tbrd-2 and testis-specific TAFs." FBgn0050412 Alliance Predicted to enable ribosome binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane from matrix. Predicted to be active in mitochondrial inner membrane. FBgn0034842 Alliance "Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to several human genes including PSMB5 (proteasome 20S subunit beta 5)." FBgn0034840 Alliance Is expressed in organism. FBgn0003009 FlyBase Gene Snapshot "orientation disruptor (ord) encodes a chromosome-localized protein required for meiotic sister chromatid cohesion in both sexes. In oocytes, it also promotes normal formation and maintenance of the synaptonemal complex and centromere clustering." FBgn0034838 Alliance Predicted to enable RNA binding activity and ubiquitin binding activity. Predicted to be involved in RNA export from nucleus and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to be part of nuclear pore. FBgn0034837 FlyBase Gene Snapshot Ribosomal protein L22-like (RpL22-like) encodes a eukaryotic-specific component of the large ribosomal subunit involved in protein synthesis. FBgn0040063 Alliance Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be part of proteasome core complex. FBgn0034834 FlyBase Gene Snapshot Large Subunit 2 (LS2) encodes an RNA binding protein that regulates both RNA splicing and gene silencing. FBgn0034870 Alliance Predicted to enable zinc ion binding activity. Involved in positive regulation of hemocyte proliferation. Orthologous to human LITAFD (LITAF domain containing). FBgn0041234 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9W1N5)" FBgn0050185 FlyBase Gene Snapshot "aaRS-interacting multifunctional protein 3 (AIMP3) is predicted to encode one of 3 non-enzymatic factors that combine with eight aminoacyl-tRNA synthetases to form a 'multi-synthetase complex' (MSC). The functional significance of the MSC is unclear, but the non-enzymatic factors are thought to be responsive to diverse signal transduction pathways." FBgn0034877 Alliance "Enables enzyme regulator activity. Involved in determination of adult lifespan and mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study cytochrome-c oxidase deficiency disease and mitochondrial encephalomyopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and mitochondrial complex IV deficiency nuclear type 18. Orthologous to several human genes including COX6A2 (cytochrome c oxidase subunit 6A2)." FBgn0010501 FlyBase Gene Snapshot Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy. FBgn0034880 UniProtKB Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. (UniProtKB:Q9W1M8) FBgn0015277 FlyBase Gene Snapshot "Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis." FBgn0015903 FlyBase Gene Snapshot "apontic (apt) encodes a DNA-binding protein that acts as a transcriptional regulator and can function in translational repression. It plays roles in cell migration, cell fate specification, and morphogenesis via STAT signaling pathway inhibition." FBgn0034882 Alliance Predicted to enable channel activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human AQP6 (aquaporin 6). FBgn0004795 UniProtKB "Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold. (UniProtKB:Q24573)" FBgn0034887 FlyBase Gene Snapshot "Sulfotransferase 1 (St1) encodes one out of 4 sulfotransferases that catalyze the sulfonation of many proteins, lipids and glycosaminoglycans." FBgn0016762 Alliance Predicted to enable 3'-5'-RNA exonuclease activity. Is expressed in organism. Orthologous to human ANGEL1 (angel homolog 1) and ANGEL2 (angel homolog 2). FBgn0034893 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including adult heart; dorsal pharyngeal muscle cell; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Orthologous to human MRPL43 (mitochondrial ribosomal protein L43)." FBgn0013548 FlyBase Gene Snapshot "lethal-(2)-denticleless (l(2)dtl) encodes the Cdt2 protein, which functions as a substrate receptor for a Cul4-based E3 ubiquitin ligase. The ubiquitylation and subsequent destruction of Cdt2 substrates depends on DNA synthesis that occurs during S phase or after DNA damage and includes proteins involved in genome function and maintenance." FBgn0034897 FlyBase Gene Snapshot "Sestrin (Sesn) encodes a stress-inducible protein that suppresses accumulation of reactive oxygen species and inhibits the TORC1 signaling pathway, which allows it to regulate oxidative damage." FBgn0034900 Alliance Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis and ribosomal small subunit biogenesis. Predicted to be active in nucleolus. FBgn0034902 Alliance "Predicted to be involved in regulation of heme biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including adult head; amnioserosa; anlage in statu nascendi; central brain anlage in statu nascendi; and embryonic/larval midgut primordium. Orthologous to several human genes including TMEM14C (transmembrane protein 14C)." FBgn0000562 FlyBase Gene Snapshot "egalitarian (egl) encodes an RNA binding protein that links specific mRNAs to the minus end-directed microtubule motor, cytoplasmic dynein-1." FBgn0034898 Alliance Predicted to enable purine-nucleoside phosphorylase activity. Predicted to be involved in nucleoside metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). FBgn0011297 Interactive Fly tumor suppressor gene - glycosyltransferase - glycosylation of the fly tumor necrosis factor Grindelwald FBgn0034894 FlyBase Gene Snapshot "salivary glands marred (sigmar) encodes a TNFAIP8-like (TIPE) protein family member. Its expression levels are responsive to the TNF ligand encoded by egr. The product of sigmar contribute to JNK signaling modulation, cytoskeletal remodeling and autophagy." FBgn0050183 Alliance Predicted to enable actin binding activity. Predicted to be involved in actomyosin contractile ring assembly; mitotic cytokinesis; and septin ring organization. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in actomyosin contractile ring. FBgn0011296 UniProtKB Vital role in embryonic development. (UniProtKB:P82147) FBgn0034885 Alliance "Predicted to enable channel activity. Involved in renal system process. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult head; adult heart; apoptotic amnioserosa; embryonic anal pad; and muscle cell. Orthologous to human AQP8 (aquaporin 8)." FBgn0034884 Alliance Predicted to enable channel activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human AQP8 (aquaporin 8). FBgn0034883 Alliance Enables water channel activity. Involved in renal system process. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in adult head; embryonic/larval gut; embryonic/larval midgut; and embryonic/larval salivary gland. Orthologous to human AQP8 (aquaporin 8). FBgn0034879 FlyBase Gene Snapshot Rrp4 (Rrp4) encodes a protein involved in gene expression regulation. FBgn0034878 FlyBase Gene Snapshot "pita (pita) encodes an architectural chromatin protein essential for embryonic development that organizes open chromatin in the regulatory regions (predominantly promoters). pita product functions include enhancer blocking, support of distant interactions, protection from spreading of repressed chromatin and recruitment of transcription factors." FBgn0034876 FlyBase Gene Snapshot wing morphogenesis defect (wmd) encodes an essential WD-repeat protein that is required for wing development and motor behavior. FBgn0041233 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9W1N6)" FBgn0050181 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon. FBgn0015372 FlyBase Gene Snapshot RabX1 (RabX1) encodes a small GTPase that is involved in the organization of late endosomal compartments. It promotes endolysosomal degradation by establishing tubules connecting late endosomes and lysosomes. FBgn0034871 Alliance Is expressed in adult head and adult heart. FBgn0050177 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. FBgn0034907 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in adult head. Orthologous to human REEP4 (receptor accessory protein 4). FBgn0034908 Alliance Predicted to be active in nucleus and site of double-strand break. Is expressed in organism and spermatozoon. Orthologous to human WDR70 (WD repeat domain 70). FBgn0034911 Alliance Enables glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Involved in glycine import across plasma membrane; neurotransmitter transport; and regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Orthologous to several human genes including SLC6A5 (solute carrier family 6 member 5). FBgn0034914 Alliance Predicted to enable protein-disulfide reductase activity. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including TMX1 (thioredoxin related transmembrane protein 1). FBgn0024234 FlyBase Gene Snapshot "glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release." FBgn0034919 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and organism. Used to study nuclear type mitochondrial complex I deficiency 18. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). FBgn0011236 FlyBase Gene Snapshot ken and barbie (ken) encodes a transcription factor involved in genital formation. FBgn0034920 Alliance Is expressed in adult head and adult heart. FBgn0034924 Alliance Is expressed in germline cell; organism; pole plasm; and primordial germ cell. FBgn0034928 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0034931 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and gut section. Orthologous to human WDR47 (WD repeat domain 47)." FBgn0023477 FlyBase Gene Snapshot Transaldolase (Taldo) encodes an enzyme that catalyzes the reversible conversion of D-sedheptulose 7-phosphate and D-glyceraldehyde 3-phosphate into D-erythrose 4-phosphate and beta-D-fructose 6-phosphate. It catalyzes the rate-limiting step of the non-oxidative branch of the pentose phosphate pathway. FBgn0001123 FlyBase Gene Snapshot "G protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning." FBgn0034936 Alliance "Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human STOML2 (stomatin like 2)." FBgn0034937 FlyBase Gene Snapshot "fizzy-related 2 (fzr2) is exclusively expressed in testis and encodes a protein that binds to the anaphase-promoting complex/cyclosome (APC/C). As for the related proteins encoded by fzr, fzy and cort, it activates the ubiquitin ligase activity of the APC/C and allows the recruitment of target proteins such as those encoded by CycA, CycB, CycB3 and pim." FBgn0034939 UniProtKB The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. (UniProtKB:Q9W1F4) FBgn0034943 Alliance Enables monooxygenase activity. Located in cytosol and mitochondrion. Is expressed in embryonic/larval fat body; embryonic/larval midgut; and yolk nucleus. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO1 (flavin containing dimethylaniline monoxygenase 1); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO5 (flavin containing dimethylaniline monoxygenase 5). FBgn0020764 FlyBase Gene Snapshot Aminolevulinate synthase (Alas) encodes a mitochondrial enzyme involved in cuticle barrier formation and thought to have a role in Heme biosynthesis. FBgn0003008 FlyBase Gene Snapshot orange (or) encodes an AP-3 adaptor complex component involved in ommochrome biosynthesis. FBgn0034946 Alliance Enables sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and organism. FBgn0002791 FlyBase Gene Snapshot "morula (mr) encodes the APC2 subunit of the anaphase promoting complex (APC). mr strong alleles produce lethality, metaphase arrest and neuroblast polyploidy. mr weak alleles result in female sterility, affecting the endocycle in the nurse cells, as well as metaphase arrest in early embryonic mitoses." FBgn0005612 FlyBase Gene Snapshot Sox box protein 14 (Sox14) encodes a transcription factor involved in neurogenesis and metamorphosis. FBgn0050178 Alliance Orthologous to human FHL2 (four and a half LIM domains 2) and FHL5 (four and a half LIM domains 5). FBgn0034950 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and negative regulation of glycogen biosynthetic process. Predicted to be active in cytosol and nucleus. Is expressed in adult brain; adult mushroom body; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human PASK (PAS domain containing serine/threonine kinase). FBgn0034957 Alliance Involved in axoneme assembly. Predicted to be part of radial spoke. Predicted to be active in axoneme. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to human RSPH6A (radial spoke head 6 homolog A) and RSPH4A (radial spoke head component 4A). FBgn0034959 Alliance "Predicted to enable xylosyl alpha-1,3-xylosyltransferase activity. Involved in negative regulation of Notch signaling pathway and protein O-linked glycosylation. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human XXYLT1 (xyloside xylosyltransferase 1)." FBgn0011695 UniProtKB Protein component of the posterior mating plug. (UniProtKB:Q9W1C9) FBgn0034961 Alliance Is expressed in organism. FBgn0034962 FlyBase Gene Snapshot MAN1 (MAN1) encodes a protein that functions as a tissue-specific antagonist of BMP signaling. FBgn0034964 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS12 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9W1C5)" FBgn0003353 FlyBase Gene Snapshot seizure (sei) encodes a protein involved in sound perception. FBgn0034968 FlyBase Gene Snapshot Ribosomal protein L12 (RpL12) encodes a protein of the large subunit of the ribosome. It regulates transcription of ribosomal proteins and ribosome biogenesis genes as well as interacting with the Enhancer of Trithorax and Polycomb protein encoded by corto. FBgn0034971 FlyBase Gene Snapshot Glycerol-3-phosphate acyltransferase 4 (Gpat4) encodes a de novo synthase of lysophosphatidic acid. FBgn0034970 FlyBase Gene Snapshot "yorkie (yki) encodes a transcriptional co-activator protein that is negatively regulated by Hippo signaling, which promotes its cytoplasmic localization. It functions together with DNA binding proteins, such as the product of sd, to activate transcription of a wide range of downstream targets, including genes that promote growth." FBgn0023170 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in adult fat body and organism. Orthologous to human RPL39 (ribosomal protein L39); RPL39L (ribosomal protein L39 like); and RPL39P5 (ribosomal protein L39 pseudogene 5). FBgn0034965 FlyBase Gene Snapshot pickpocket 29 (ppk29) encodes a putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone signaling and neuronal excitability. FBgn0028552 FlyBase Gene Snapshot gamma Soluble NSF attachment protein 1 (gammaSnap1) encodes a protein involved in the dorsal/ventral pattern formation of the wing disc. FBgn0011726 UniProtKB "Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568). (UniProtKB:P45594)" FBgn0034963 Alliance Involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. Orthologous to human CNOT11 (CCR4-NOT transcription complex subunit 11). FBgn0013764 FlyBase Gene Snapshot "Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance." FBgn0050172 Alliance Predicted to be located in extracellular region. Is expressed in adult head; embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. FBgn0061198 FlyBase Gene Snapshot "Haematopoietic stem/progenitor cell protein 300 (HSPC300) encodes a subunit of the Scar/WAVE complex, which activates the Arp2/3 complex at the plasma membrane to generate membrane protrusions that drive cell migration." FBgn0034956 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in embryonic anal pad; embryonic foregut; embryonic hindgut; and embryonic/larval tracheal section. Orthologous to human SVOP (SV2 related protein). FBgn0034951 Alliance "Predicted to enable sterol binding activity. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including adult head; ganglia; gastric caecum; gonad; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to several human genes including OSBPL2 (oxysterol binding protein like 2)." FBgn0034948 FlyBase Gene Snapshot Protein phosphatase 1 regulatory subunit 15 (PPP1R15) encodes a regulatory subunit of protein phosphatase 1. It mediates the dephosphorylation of the translation initiation factor encoded by eIF2alpha. This antagonises the effects of the stress sensing kinases encoded by PEK and Gcn2 promoting cap-dependent translation. FBgn0034945 Alliance Is expressed in organism. FBgn0034940 Alliance Is expressed in adult head; embryonic hindgut; embryonic proventriculus; embryonic/larval midgut; and organism. Orthologous to human C6orf136 (chromosome 6 open reading frame 136). FBgn0034938 Alliance "Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Predicted to be involved in heme A biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and testis. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15)." FBgn0034935 FlyBase Gene Snapshot "Orcokinin (Orcokinin) encodes a neuropeptide whose knockdown causes a disinhibition of male courtship behavior, including the occurrence of male to male courtship, and a reduction in egg production." FBgn0034933 Alliance "Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in embryonic/larval hypodermal muscle cell. Orthologous to human UTP25 (UTP25 small subunit processome component)." FBgn0015268 FlyBase Gene Snapshot Nucleosome assembly protein 1 (Nap1) encodes a core histone chaperone involved in histone nuclear transfer and chromatin assembly. FBgn0034925 Alliance "Predicted to enable protein-L-histidine N-pros-methyltransferase activity. Is expressed in adult head and organism. Orthologous to human METTL9 (methyltransferase 9, His-X-His N1(pi)-histidine)." FBgn0034923 FlyBase Gene Snapshot Upf3 (Upf3) encodes a protein that regulates targets of the nonsense-mediated mRNA decay pathway. This pathway participates in homeostatic gene expression regulation and plays a quality control role in the elimination of mRNAs with premature termination codons. The product of Upf3 is involved in cell cycle progression and general developmental rate. FBgn0034921 FlyBase Gene Snapshot Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing. FBgn0025334 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in embryonic brain and larval ventral nerve cord. Human ortholog(s) of this gene implicated in colorectal cancer; congenital central hypoventilation syndrome; congenital fibrosis of the extraocular muscles 2; and neuroblastoma. Orthologous to several human genes including PHOX2B (paired like homeobox 2B)." FBgn0025336 Alliance "Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human MRPS27 (mitochondrial ribosomal protein S27)." FBgn0025352 FlyBase Gene Snapshot Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation. FBgn0025335 UniProtKB Catalyzes the biosynthesis of ceramide phosphoethanolamine (CPE) through the transfer of a phosphatidyl head group from cytidine 5'-diphosphate (CDP)-ethanolamine on to the primary hydroxyl of ceramide. (UniProtKB:O77475) FBgn0004581 FlyBase Gene Snapshot benign gonial cell neoplasm (bgcn) encodes an RNA-binding protein involved in germline stem cell lineage differentiation. It forms a translational repressor complex with the product of bam in ovaries and with the products of bam and tut in testis. FBgn0034918 UniProtKB "Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit or components of the translation initiation complex. May not function in cap-dependent translation regulation. (UniProtKB:P82804)" FBgn0021895 FlyBase Gene Snapshot yantar (ytr) encodes a conserved arginine-rich protein involved in alternative splicing and hemocyte differentiation. FBgn0034915 UniProtKB Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (UniProtKB:P56538) FBgn0034913 FlyBase Gene Snapshot "Synaptosomal-associated protein 29kDa (Snap29) encodes a member of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family. It is involved in regulation of autophagy, endocytic recycling and cell division." FBgn0003401 FlyBase Gene Snapshot shutdown (shu) encodes an immunophilin cochaperone that collaborates with Hsp90 during piRNA biogenesis and is essential for normal function of germline stem cells. FBgn0034909 Alliance Enables glucose transmembrane transporter activity and trehalose transmembrane transporter activity. Involved in glucose transmembrane transport and trehalose transport. Is active in plasma membrane. Is expressed in adult fat body and adult head. FBgn0028411 UniProtKB "Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In ovaries, plays a role in transposable element silencing regulation (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835, PubMed:33856346). Forms a complex with nxf2, Panx and piwi which acts as effector of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). In ovarian follicle cells, enables the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346). (UniProtKB:Q9V3H8)" FBgn0010278 UniProtKB "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes. (UniProtKB:Q05344)" FBgn0034904 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. FBgn0034973 Alliance Involved in defense response to bacterium. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). FBgn0034974 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic epipharynx; epithelium; gut section; and primary segmental tracheal branch primordium." FBgn0034975 FlyBase Gene Snapshot "enoki mushroom (enok) encodes a MYST family histone acetyltransferase that acetylates lysine residues on histones, including H3K23, to regulate gene transcription. It contributes to stem cell self-renewal, oogenesis and neural development." FBgn0041706 Alliance "Predicted to enable glucuronosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A13. Orthologous to human B4GAT1 (beta-1,4-glucuronyltransferase 1)." FBgn0021875 FlyBase Gene Snapshot "Zinc finger protein RP-8 (Zfrp8) encodes a highly conserved protein essential for stem cell maintenance and fast proliferating cells such as cancer cells. It functions in the formation of mRNA ribonucleoprotein (mRNP) complexes. It may regulate the binding of specific mRNPs to the small ribosomal subunit, ultimately controlling their cytoplasmic localization and translation." FBgn0015544 FlyBase Gene Snapshot "spaghetti (spag) encodes a TPR domain-containing co-chaperone that associates with Hsp70 and Hsp90 to regulate their activity in macromolecular complexes like RNA polymerase, ribonucleoproteins and Phosphatidyl-Inositol 3-kinase-related kinases. It has been shown to regulate the product of dco levels, with consequences for circadian rhythms and apoptosis." FBgn0034985 Alliance "Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and protein autoprocessing. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in several structures, including embryonic anal pad; embryonic hindgut; embryonic large intestine; embryonic ventral epidermis; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor) and MYRFL (myelin regulatory factor like)." FBgn0026169 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0034988 UniProtKB "Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity (PubMed:23223233). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233, PubMed:24603684). (UniProtKB:Q9W197)" FBgn0034989 Alliance Enables ubiquitin conjugating enzyme binding activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is expressed in adult head and organism. Orthologous to human UBE3C (ubiquitin protein ligase E3C). FBgn0050418 UniProtKB "Secretory protein that acts as a feedback regulator of dpp/BMP, wg and hh signaling pathways (PubMed:35037619, PubMed:35609633). In the developing wing, is a dosage-dependent modulator of dpp/BMP signaling involved in wing growth and crossvein patterning; low levels promote and high levels inhibit dpp/BMP signaling (PubMed:35037619, PubMed:35609633). In the early pupal wing, inhibits dpp/BMP signaling activity to prevent the formation of ectopic crossveins in the posterior compartment (PubMed:35037619, PubMed:35609633). Binds to dpp and gbb to modulate their release and activity decreasing dpp/BMP signaling in the responding cells (PubMed:35037619, PubMed:35609633). During wing development regulates dpp/BMP coreceptor dally availability on the cell surface (PubMed:35609633). Might have a role in testis development (PubMed:35609633). (UniProtKB:Q9W192)" FBgn0034996 Alliance Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0005636 FlyBase Gene Snapshot nervy (nvy) is a member of the MTG family of genes that have both nuclear and cytosolic functions. nvy encodes a transcriptional repressor and an A kinase anchoring protein (AKAP). It regulates repulsive axon guidance and functions in Plexin and Notch signaling pathways. FBgn0034999 Alliance "Predicted to enable long-chain fatty acid transmembrane transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval crystal cell; embryonic/larval muscle system; and epithelium. Orthologous to human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4)." FBgn0004101 FlyBase Gene Snapshot "blistered (bs) encodes the Drosophila ortholog of mammalian Serum Response Factor (SRF). It is a sequence-specific transcription factor contributing to intervein cell specification in the wing, tracheal terminal branching and flight muscle maturation." FBgn0005638 FlyBase Gene Snapshot "slow border cells (slbo) encodes an essential transcriptional activator. Although null mutants are lethal, female-sterile alleles exhibit a specific defect in border cell migration during ovarian development. In this context, Jak/STAT signaling controls slbo expression, which in turn regulates hundreds of downstream targets including the product of shg." FBgn0034994 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult. FBgn0034986 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and trunk mesoderm. Orthologous to human MRPS17 (mitochondrial ribosomal protein S17)." FBgn0041582 FlyBase Gene Snapshot tamo (tamo) encodes a protein with an essential function during oogenesis where it interacts with the product of dl and proteins that are part of the nuclear import machinery. FBgn0023081 UniProtKB Acts as a downstream effector for the regulation of actin polymerization by Cdc42. (UniProtKB:Q9W1B0) FBgn0034972 Alliance "Predicted to enable neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to be active in cell surface and postsynaptic membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN4X (neuroligin 4 X-linked) and NLGN4Y (neuroligin 4 Y-linked)." FBgn0002787 UniProtKB Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (UniProtKB:P26270) FBgn0035005 Alliance Predicted to enable isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. FBgn0035007 Alliance Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. FBgn0035008 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Orthologous to human LRRC30 (leucine rich repeat containing 30). FBgn0035009 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. FBgn0035010 Alliance Predicted to enable corazonin receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0029501 Alliance Is expressed in spermatozoon. FBgn0035014 Alliance Orthologous to human SPMIP1 (sperm microtubule inner protein 1). FBgn0050169 FlyBase Gene Snapshot "BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9." FBgn0035020 Alliance Predicted to be active in endoplasmic reticulum. Is expressed in embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human SMIM14 (small integral membrane protein 14). FBgn0035023 FlyBase Gene Snapshot "Ion transport peptide (ITP) encodes three identified alternative splice-forms of neuropeptides, one short and two longer forms. The short isoform is produced in several neurosecretory neurons and interneurons in the CNS controling the evening peak of locomotor activity of the fly." FBgn0035024 Alliance "Predicted to enable several functions, including ribosome binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in mitotic cell cycle. Is expressed in adult head. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase)." FBgn0035025 UniProtKB "Inhibits the activity of serine/threonine-protein phosphatases flw/PP1beta9C and Pp1-87B. Required for germ line cell viability and differentiation, normal transcriptional activity and maintenance of DNA integrity. (UniProtKB:Q9W148)" FBgn0035027 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be part of catalytic step 2 spliceosome. Is expressed in organism. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). FBgn0020521 FlyBase Gene Snapshot piopio (pio) encodes a zona pellucida (ZP) domain protein that mediates the adhesion of the apical epithelial surface and the overlying apical extracellular matrix. FBgn0035034 Alliance Predicted to enable calcium ion binding activity. FBgn0035035 UniProtKB "S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1 (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. (UniProtKB:Q9W138)" FBgn0035039 UniProtKB "Essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L to regulate the mitochondrial structural proteins Opa1 and Mitofilin (PubMed:31125351). This function is likely to be kinase-independent (By similarity). Functions in tracheal development and larval molting probably by acting in sterol modification and/or intracellular lipid trafficking (PubMed:31175694). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). (UniProtKB:Q9W133)" FBgn0015040 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9W130) FBgn0035042 Alliance Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in adult head. FBgn0035044 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Orthologous to several human genes including ISOC1 (isochorismatase domain containing 1)." FBgn0035046 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)." FBgn0035047 FlyBase Gene Snapshot Painting of fourth (Pof) encodes a protein that binds to nascent RNA from actively transcribed genes and increases their expression levels. It specifically targets the 4th chromosome and two loci on the X-chromosome. FBgn0035049 FlyBase Gene Snapshot "Matrix metalloproteinase 1 (Mmp1) encodes a proteinase that cleaves proteins in the extracellular matrix. It is involved in tissue histolysis and remodeling during metamorphosis, tracheal remodeling, wound healing, wing regeneration, neoplastic growth, and circadian behavior. It has been used as a reporter for JNK signaling since it is upregulated by the pathway." FBgn0260456 Alliance "Predicted to enable mRNA binding activity. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28)." FBgn0050163 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0035043 Alliance Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and gastric caecum. FBgn0035041 Alliance Is expressed in wing hinge primordium and wing pouch. FBgn0035036 Alliance Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). FBgn0035032 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). (UniProtKB:Q9W141)" FBgn0069913 Alliance Orthologous to human TEX9 (testis expressed 9). FBgn0035026 Alliance Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Located in nucleus and polytene chromosome. Is expressed in nurse cell. Orthologous to human CTDP1 (CTD phosphatase subunit 1). FBgn0016687 UniProtKB "Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin (PubMed:9784495). NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:8521501, PubMed:9784495). Inorganic pyrophosphatase (PPase), hydrolyzes inorganic pyrophosphate to inorganic phosphate, essential for driving critical biosynthetic reactions including transcription, replication, and DNA repair (PubMed:9784495). (UniProtKB:O77460)" FBgn0035019 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis. FBgn0035016 Alliance "Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Involved in long-term memory and positive regulation of translation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; ganglia; and nephrocyte. Orthologous to several human genes including PABPC4L (poly(A) binding protein cytoplasmic 4 like) and PABPC5 (poly(A) binding protein cytoplasmic 5)." FBgn0017556 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:Q27575)" FBgn0015300 Alliance Enables protein kinase regulator activity. Predicted to be part of protein kinase CK2 complex. Predicted to be active in cytoplasm. FBgn0035006 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. FBgn0035004 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Involved in positive regulation of mitochondrial fission. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)." FBgn0035003 Alliance Predicted to be involved in proteolysis. FBgn0010414 UniProtKB Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals. (UniProtKB:P51905) FBgn0000037 UniProtKB "The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. (UniProtKB:P16395)" FBgn0050421 FlyBase Gene Snapshot Ubiquitin specific protease 15/31 (Usp15-31) encodes a ubiquitin C-terminal hydrolase that is involved in the positive regulation of the apoptosome components encoded by Dark and Dronc. FBgn0035056 Alliance Predicted to enable Toll binding activity and growth factor activity. Predicted to be involved in central nervous system formation and innate immune response. Located in extracellular space. Is expressed in embryonic head; embryonic/larval epidermis; embryonic/larval hindgut; and embryonic/larval tracheal section. FBgn0035057 Alliance Orthologous to human SAPCD2 (suppressor APC domain containing 2). FBgn0035059 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in intracellular signal transduction. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). FBgn0035063 Alliance Predicted to enable mRNA binding activity. FBgn0035065 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing and regulation of fatty acid beta-oxidation. Predicted to be active in peroxisome. Is expressed in adult head and organism. Orthologous to human TYSND1 (trypsin like peroxisomal matrix peptidase 1). FBgn0000157 FlyBase Gene Snapshot Distal-less (Dll) encodes a homedomain transcription factor whose expression is induced in limb primordia and specifies limb (distal) versus body wall (proximal). FBgn0035070 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in salivary gland. FBgn0035077 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic hypopharynx; and embryonic ventral epidermis. FBgn0022343 Alliance Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human CDV3 (CDV3 homolog). FBgn0035085 Alliance Predicted to be located in septate junction. Predicted to be active in membrane. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). FBgn0035086 Alliance Is expressed in wing hinge primordium and wing pouch. FBgn0035088 Alliance Predicted to enable ribosome binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human MAIP1 (matrix AAA peptidase interacting protein 1). FBgn0035091 FlyBase Gene Snapshot between emp and zip (bez) encodes a scavenger receptor class B protein involved in lipid export from fat body cells. It has functional interactions with apolpp. FBgn0004055 FlyBase Gene Snapshot unzipped (uzip) encodes a cell adhesion molecule that genetically interacts with CadN. Its biological function includes regulation of axon guidance. FBgn0010435 Alliance "Predicted to enable scavenger receptor activity. Involved in regulation of tube length, open tracheal system. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; epidermis; gut section; imaginal disc; and tracheal system. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to several human genes including SCARB2 (scavenger receptor class B member 2)." FBgn0035090 Alliance Predicted to enable scavenger receptor activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic/larval fat body; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). FBgn0035089 Alliance "Involved in metamorphosis and response to bacterium. Predicted to be located in extracellular space. Is expressed in several structures, including Bolwig organ; cuboidal/columnar epithelium; embryonic head epidermis; embryonic head sensory system; and gut section." FBgn0050424 UniProtKB "Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP from ATP and GTP and plays a key role in antiviral innate immunity (PubMed:34261128). Directly binds some unknown nucleic acid, activating the nucleotidyltransferase activity, leading to synthesis of both 3',2'-cGAMP and 2',3'-cGAMP second messengers (PubMed:34261128). 3',2'-cGAMP and 2',3'-cGAMP bind to and activate Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261128). (UniProtKB:A8DYP7)" FBgn0035087 Alliance "Enables myosin binding activity. Predicted to be involved in regulation of lipid biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including dorsal imaginal tissue; embryonic dorsal epidermis; embryonic/larval midgut; embryonic/larval oenocyte; and embryonic/larval somatic muscle cell. Orthologous to several human genes including MID1IP1 (MID1 interacting protein 1)." FBgn0027599 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). FBgn0035084 Alliance Is expressed in embryonic hindgut and embryonic large intestine. FBgn0035082 UniProtKB Putative gamma-glutamylcyclotransferase. (UniProtKB:Q9W0Y2) FBgn0043792 FlyBase Gene Snapshot "CG30427 encodes a fatty-acyl-CoA reductase involved in production of NADPH, sensory perception of pain, phagocytosis and determination of lifespan." FBgn0060296 FlyBase Gene Snapshot painless (pain) encodes a non-selective cation channel in the TRPA family that is required for the detection of noxious heat and mechanical stimuli. FBgn0035078 Alliance Predicted to enable antiporter activity and thiamine transmembrane transporter activity. Predicted to be involved in mitochondrial thiamine pyrophosphate transmembrane transport. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). FBgn0035076 Alliance Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in adult head. FBgn0035073 Alliance Predicted to enable GTPase activator activity. Predicted to be active in centrosome. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human TBC1D31 (TBC1 domain family member 31). FBgn0023181 FlyBase Gene Snapshot "Origin recognition complex subunit 4 (Orc4) encodes is a subunit of the hetero-hexameric origin recognition complex (ORC). The ORC binds to origins of DNA replication and scaffolds assembly of a pre-replicative complex, which is required for the initiation of DNA replication. At other loci, the ORC is required for heterochromatin formation." FBgn0028738 FlyBase Gene Snapshot "Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality." FBgn0015801 UniProtKB "Involved in the generation of biological rhythms (Potential). In the head, oscillates in abundance with a daily peak during early night, even under constant darkness. Oscillation is dependent on period (per) function. (UniProtKB:Q94913)" FBgn0041205 FlyBase Gene Snapshot "kenny (key) encodes a scaffold protein that is a component of the IKK (IkappaB Kinase) complex, which participates in the activation of the transcription factor Rel in the Imd pathway. This pathway regulates the antibacterial response and other less characterized cellular processes." FBgn0035064 FlyBase Gene Snapshot "Tyrosyl-tRNA synthetase, mitochondrial (TyrRS-m) encodes an enzyme that catalyzes the ligation of tyrosine to the mitochondrial-encoded tRNA-Tyr. The TyrRS-m protein is encoded by a nuclear gene and imported to the mitochondria where it functions in mitochondrial protein synthesis." FBgn0025578 UniProtKB Component of the cuticle of the larva. (UniProtKB:P82384) FBgn0035060 FlyBase Gene Snapshot "Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation." FBgn0027590 FlyBase Gene Snapshot Glutathione S transferase E12 (GstE12) encodes an enzyme involved in glutathione metabolism. FBgn0040666 Alliance Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrial ribosome. Predicted to be active in mitochondrion and nucleoplasm. Is expressed in adult head. Orthologous to human CHCHD1 (coiled-coil-helix-coiled-coil-helix domain containing 1). FBgn0035050 FlyBase Gene Snapshot "Sialyltransferase (SiaT) encodes an enzyme that functions in the sialylation pathway. It is required to produce sialylated glycans, which are important for nervous system function. It contributes to lifespan, locomotor abnormalities, response to heat and neuromuscular junction development." FBgn0035092 Alliance "Enables neuropeptide hormone activity. Involved in receptor guanylyl cyclase signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including DN1a neurons; anterior-posterior subdivision of organism; brain; embryonic central brain neurons; and embryonic/larval neurons." FBgn0050198 Alliance Predicted to enable GCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050199 Alliance Predicted to enable GCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050200 Alliance Predicted to enable GCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0001325 UniProtKB Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules. (UniProtKB:P07247) FBgn0050429 Alliance Is expressed in spermatozoon. Orthologous to human MORN3 (MORN repeat containing 3). FBgn0050428 Alliance Predicted to be active in nucleus. FBgn0035094 Alliance Is expressed in adult head. FBgn0004181 FlyBase Gene Snapshot Ejaculatory bulb protein (Ebp) encodes a 377-amino acid protein produced in the male ejaculatory bulb. It is essential for the formation and integrity of the posterior mating plug formed in females after mating. FBgn0011694 UniProtKB Protein component of the posterior mating plug. (UniProtKB:Q23982) FBgn0004919 FlyBase Gene Snapshot "goliath (gol) encodes an E3 ubiquitin ligase, whose cellular substrates are unknown. During embyrogenesis gol is expressed in fusion-competence myoblasts of the somatic and visceral mesoderm." FBgn0001147 UniProtKB Expressed in a segmentally repeating pattern to define the polarity of embryonic segments. (UniProtKB:P09083) FBgn0052475 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval optic lobe; eye disc morphogenetic furrow; eye disc posterior to the morphogenetic furrow; and ocellar triangle. FBgn0002564 UniProtKB Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (UniProtKB:P11997) FBgn0020386 UniProtKB "Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. (UniProtKB:Q9W0V1)" FBgn0035099 Alliance Predicted to be located in membrane. Orthologous to human DCST2 (DC-STAMP domain containing 2). FBgn0035101 FlyBase Gene Snapshot p130CAS (p130CAS) encodes an SH3 domain-containing protein phosphorylated by Src kinases. It contributes to integrin-mediated adhesion and in vertebrate cells is phosphorylated in response to mechanical stretch. FBgn0035104 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section. Orthologous to several human genes including RASSF10 (Ras association domain family member 10)." FBgn0027786 Alliance "Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Used to study dilated cardiomyopathy. Orthologous to human MTCH1 (mitochondrial carrier 1) and MTCH2 (mitochondrial carrier 2)." FBgn0035107 FlyBase Gene Snapshot "mrityu (mri) encodes a BTB/POZ domain containing protein. Its expression is regulated by the product of klu during retinal apoptosis. mri protein is phosphorylated upon egg activation, and is required for early embryo development and for the normal sensory perception of touch." FBgn0024945 FlyBase Gene Snapshot Nitrilase and fragile histidine triad fusion protein (NitFhit) encodes a bis(5'-adenosyl)-triphosphatase involved in nucleobase-containing compound metabolism. FBgn0035109 Alliance Orthologous to human C3orf38 (chromosome 3 open reading frame 38). FBgn0035111 FlyBase Gene Snapshot Dis3 like 3'-5' exoribonuclease 2 (Dis3l2) encodes a 3'-5'-exoribonuclease involved in catabolism of miRNA and tRNA. FBgn0053229 Alliance Is expressed in organism and yolk nucleus. FBgn0052476 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in adult head; embryonic/larval foregut; and embryonic/larval midgut. FBgn0035120 FlyBase Gene Snapshot "wee Augmin (wac) encodes a subunit of the hetero-octomeric Augmin complex, which functions to recruit the gamma-tubulin ring complex to pre-existing microtubules, facilitating microtubule-dependent microtubule nucleation." FBgn0035122 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head; adult heart; embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human MRPL17 (mitochondrial ribosomal protein L17). FBgn0027111 FlyBase Gene Snapshot midkine and pleiotrophin 1 (miple1) encodes a small secreted protein that binds Heparin and is closely related at the amino acid sequence to the product of miple2. It is mainly expressed in the developing CNS. FBgn0029002 FlyBase Gene Snapshot midkine and pleiotrophin 2 (miple2) encodes a small secreted protein that binds Heparin and is closely related at the amino acid sequence to the product of miple1. It is strongly expressed in the developing endoderm. FBgn0035124 FlyBase Gene Snapshot tiny tim 2 (ttm2) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. FBgn0004373 FlyBase Gene Snapshot four wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility. FBgn0052845 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be active in cytosol and nucleus. FBgn0035121 UniProtKB "Endonuclease which shows activity towards both DNA and RNA substrates (PubMed:14508492, PubMed:26808625). Has a role in translation regulation throught its association with the with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:26808625). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline (PubMed:26808625). Together with piwi, might be involved in transposon repression in the germline (PubMed:26808625). (UniProtKB:Q9W0S7)" FBgn0024806 FlyBase Gene Snapshot DISCO Interacting Protein 2 (DIP2) encodes a member of DIP2 family. It interacts physically with the product of disco in vitro and participates in axonal bifurcation and guidance downstream of the JNK pathway. FBgn0000541 UniProtKB "Histone-binding component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. Required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. (UniProtKB:Q9W0T1)" FBgn0035113 UniProtKB Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments. (UniProtKB:Q9W0T5) FBgn0035110 UniProtKB The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. (UniProtKB:Q8IRJ8) FBgn0027587 Alliance Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of hippo signaling. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human PRP4K (pre-mRNA processing factor kinase PRP4K). FBgn0025592 Alliance "Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase); GK2 (glycerol kinase 2); and GK3 (glycerol kinase 3)." FBgn0035106 FlyBase Gene Snapshot "rhinoceros (rno) encodes a nuclear protein that functions in the Egfr signaling pathway, downstream of MAP kinase activation, and regulates transcription of Egfr targets. It is involved in cell differentiation and developmental patterning." FBgn0035103 Alliance "Predicted to enable ubiquitin protein ligase binding activity. Involved in cell redox homeostasis and negative regulation of removal of superoxide radicals. Located in cytoplasm and nucleus. Is expressed in several structures, including adult fat body; epidermis; germline cell; glial cell; and gut section. Orthologous to human ARRDC1 (arrestin domain containing 1)." FBgn0035102 Alliance Predicted to enable formylglycine-generating oxidase activity. Predicted to be involved in protein modification process. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1). FBgn0040688 Alliance Is expressed in organism. FBgn0035134 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be located in nucleus. Orthologous to several human genes including ZMAT3 (zinc finger matrin-type 3). FBgn0040291 FlyBase Gene Snapshot "Regulator of cullins 1b (Roc1b) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul3 and recruits ubiquitin-charged E2 to the CRL3 E3 ubiquitin ligase complex, which functions during spermatogenesis." FBgn0035137 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human ZNF316 (zinc finger protein 316) and ZNF787 (zinc finger protein 787)." FBgn0035140 Alliance Predicted to be involved in lysosome localization. Predicted to be part of BORC complex. Orthologous to human BORCS6 (BLOC-1 related complex subunit 6). FBgn0035142 FlyBase Gene Snapshot "Homeodomain interacting protein kinase (Hipk) encodes a protein that belongs to the DYRK family kinases. It can modulate signaling pathways including Wingless, Notch, Hippo, Hedgehog, JNK, and cell death. It plays roles in development, proliferation and patterning of many tissues, including the eye, wing, and the embryo." FBgn0035143 Alliance "Predicted to enable phosphoprotein phosphatase activity. Is expressed in adult head. Orthologous to human PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative))." FBgn0035145 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9W0P8)" FBgn0035147 FlyBase Gene Snapshot UDP-galactose 4'-epimerase (Gale) encodes an enzyme that epimerizes UDP-glucose to UDP-galactose and UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. It is involved in galactose metabolism and the synthesis of nucleotide sugars. FBgn0035150 FlyBase Gene Snapshot Rev1 DNA directed polymerase (Rev1) encodes a translesion DNA polymerase with deoxycytidyl transferase activity. It interacts with multiple other translesion polymerases and plays roles in tolerance and repair of DNA damage. FBgn0035149 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (UniProtKB:Q9W0P3)" FBgn0035148 Alliance Is expressed in organism. Orthologous to human TAX1BP3 (Tax1 binding protein 3). FBgn0016715 Alliance "Predicted to be active in nucleus. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; and visceral mesoderm derivative. Orthologous to human HDHD3 (haloacid dehalogenase like hydrolase domain containing 3)." FBgn0035146 Alliance "Predicted to enable phosphatidylcholine transporter activity and phosphatidylinositol transfer activity. Predicted to be involved in phospholipid transport. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic head sensory system; embryonic/larval nervous system; embryonic/larval posterior spiracle; and ganglia. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2); SEC14L3 (SEC14 like lipid binding 3); and SEC14L4 (SEC14 like lipid binding 4)." FBgn0035144 FlyBase Gene Snapshot "Kahuli (Kah) encodes a member of the Snail/Scratch family of transcription factors, which regulate transcription by binding the E-box motif ACAGGTG." FBgn0035141 Alliance "Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 14. Orthologous to human PPIL1 (peptidylprolyl isomerase like 1)." FBgn0001316 FlyBase Gene Snapshot klarsicht (klar) encodes a member of the Nesprin family that links microtubule motors and various cellular structures. It controls the migration and positioning of nuclei in photoreceptors and muscles. It also regulates the motion of RNP granules in oocytes and lipid droplets in embryos. FBgn0023000 FlyBase Gene Snapshot methuselah (mth) encodes a member of the Class B secretin family of G-protein-coupled receptors involved in lifespan. mth product also plays a role in the processes of learning and memory formation via the CREB pathway. FBgn0035132 Interactive Fly Growth-blocking peptides initiate signaling in surrounding epithelial cells through the G-protein-coupled receptor Mthl10 - activation of tissue repair through activation of calcium signaling FBgn0035131 Alliance "Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic large intestine; embryonic telson; and gut section." FBgn0052343 FlyBase Gene Snapshot Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation. FBgn0052344 Alliance "Predicted to enable RNA helicase activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including anal pad primordium; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human DDX54 (DEAD-box helicase 54)." FBgn0035155 Alliance "Predicted to enable GTPase activity. Predicted to be involved in several processes, including Rab protein signal transduction; autophagosome assembly; and intracellular protein transport. Located in neuronal cell body. Is expressed in several structures, including Bolwig organ; adult ensheathing glial cell; brain; imaginal disc; and synaptic neuropil domain." FBgn0052480 Alliance Predicted to enable AUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052481 Alliance Predicted to enable AUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035165 Alliance "Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; germline cell; and salivary gland body primordium. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP29 (B cell receptor associated protein 29) and BCAP31 (B cell receptor associated protein 31)." FBgn0035167 UniProtKB One of the few identified sugar gustatory receptors identified so far with glucose being its primary ligand and which mediates acceptance behavior. (UniProtKB:Q9W0M2) FBgn0035168 FlyBase Gene Snapshot "Centrosomal protein 290kDa (Cep290) encodes a cytoplasmic protein located in the cilium transition zone, which assists in the compartmentalization of the cilium in sensory cilia, and the ciliary tip in sperm flagella. Its roles include coordinated movement behavior and sperm motility." FBgn0035169 FlyBase Gene Snapshot "Dodecenoyl-CoA delta-isomerase (Dci) encodes a protein that, when overexpressed, extends lifespan, enhances stress tolerance to oxidative and starvation stress and activates the product of foxo." FBgn0035171 Alliance Is expressed in spermatozoon. Orthologous to human TMEM200A (transmembrane protein 200A) and TMEM200C (transmembrane protein 200C). FBgn0052479 Alliance Predicted to enable cysteine-type deubiquitinase activity. Involved in positive regulation of Notch signaling pathway. Located in cytosol. Is expressed in adult brain cell body rind and adult head. Orthologous to human USP10 (ubiquitin specific peptidase 10). FBgn0035176 Alliance Enables lipid binding activity. Is expressed in adult head. FBgn0028999 FlyBase Gene Snapshot "nervous fingers 1 (nerfin-1) encodes a zinc finger transcription factor that regulates early axon guidance at the embryonic stage and is required for the maintenance of larval neuron differentiation. In the larval medulla cortex, nerfin-1 is expressed in medulla neurons at the early stage and protects them from dedifferentiation via the repression of Notch signaling pathway." FBgn0035173 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in adult head; organism; and yolk nucleus. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14). FBgn0035170 Alliance "Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval nervous system; ganglia; and head epidermis primordium." FBgn0035166 Alliance Predicted to enable chromatin binding activity and histone H3K36 demethylase activity. Predicted to be involved in G2/M transition of mitotic cell cycle. Located in cytoplasm. Orthologous to human KDM8 (lysine demethylase 8). FBgn0035164 Alliance Predicted to be involved in cilium movement. Orthologous to human DPCD (deleted in primary ciliary dyskinesia homolog (mouse)). FBgn0035162 UniProtKB "Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:18981222). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:18981222). Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). (UniProtKB:Q9W0M7)" FBgn0035161 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. FBgn0052482 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035160 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval garland cell; embryonic/larval peripheral nervous system; gland; and imaginal disc." FBgn0025676 Alliance Is expressed in olfactory sensory organ. FBgn0035158 Alliance Predicted to enable DNA binding activity. FBgn0035157 Alliance "Is expressed in several structures, including amnioserosa primordium; anlage in statu nascendi; cuboidal/columnar epithelium; ganglia; and head epidermis primordium." FBgn0052483 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human SCPEP1 (serine carboxypeptidase 1). FBgn0035154 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in embryonic/larval tracheal dorsal trunk and organism. Orthologous to human SCPEP1 (serine carboxypeptidase 1). FBgn0035153 FlyBase Gene Snapshot earthbound 1 (ebd1) encodes a transcription cofactor that functions in the Wingless/Wnt signal transduction pathway. It promotes the interaction between the products of arm and pan and helps recruit the product of arm to chromatin. The product of ebd1 functions in a context-specific manner and is important for the development of indirect flight muscles. FBgn0035152 Alliance Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. FBgn0035151 Alliance Is expressed in organism. FBgn0035179 Alliance "Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; embryonic/larval nervous system; and ganglia. Orthologous to human DIPK1C (divergent protein kinase domain 1C)." FBgn0035181 Alliance Is expressed in organism. FBgn0035186 Alliance "Is expressed in several structures, including CNS glial cell; endoderm anlage; ganglia; head epidermis primordium; and mesoderm." FBgn0040281 FlyBase Gene Snapshot "APPL-interacting protein 1 (Aplip1) encodes a scaffolding protein that can bind to several proteins such as Klc, Appl, and hep. Aplip1 can link Khc to vesicles and has roles in fast axonal transport that are important for neuron structure and function." FBgn0004425 UniProtKB Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. (UniProtKB:Q08694) FBgn0004426 Alliance Is expressed in adult midgut and embryonic/larval midgut. FBgn0004428 UniProtKB Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. (UniProtKB:P37159) FBgn0004430 UniProtKB Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. (UniProtKB:P37160) FBgn0004429 UniProtKB Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. (UniProtKB:P29615) FBgn0004427 UniProtKB Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. (UniProtKB:P83972) FBgn0035189 Alliance "Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be active in nucleus. Is expressed in several structures, including adult head; embryonic/larval crystal cell; embryonic/larval midgut primordium; gut section; and procrystal cell. Orthologous to human C11orf54 (chromosome 11 open reading frame 54)." FBgn0063667 Alliance "Enables hydrolase activity, acting on ester bonds. Involved in cellular response to glucose stimulus and positive regulation of insulin receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human C11orf54 (chromosome 11 open reading frame 54)." FBgn0004431 UniProtKB Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis. (UniProtKB:P37161) FBgn0035187 FlyBase Gene Snapshot Tryptophan hydroxylase neuronal (Trhn) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. FBgn0025525 FlyBase Gene Snapshot "bric a brac 2 (bab2) encodes a transcriptional regulator that functions partially redundantly with the product of bab1. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity." FBgn0004870 FlyBase Gene Snapshot "bric a brac 1 (bab1) encodes a transcriptional regulator that functions partially redundantly with the product of bab2. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity." FBgn0024277 FlyBase Gene Snapshot "trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development." FBgn0035192 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. Used to study heart conduction disease. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). FBgn0035196 UniProtKB "Transcriptional cofactor involved in efferocytosis (PubMed:34860835). Together with srp mediates expression of the phagocytic receptor crq/croquemort in response to apoptotic cells, and is up-regulated by crq/croquemort in a positive feedback mechanism (PubMed:34860835). Involved in macrophage engulfment and clearance of apoptotic cells during embryogenesis (PubMed:34860835). (UniProtKB:Q9W0I5)" FBgn0035199 Alliance "Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Is expressed in embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and larval imaginal tissue. Human ortholog(s) of this gene implicated in several diseases, including dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); lung disease (multiple); respiratory syncytial virus infectious disease; and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2)." FBgn0035203 Alliance "Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2)." FBgn0035205 FlyBase Gene Snapshot "Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system." FBgn0035207 FlyBase Gene Snapshot HECT and RLD domain containing E3 ubiquitin ligase 4 (Herc4) encodes a HECT-type E3 ubiquity ligase that is involved in the host defense against Gram-positive bacteria mediated by Toll pathway. FBgn0010246 UniProtKB "Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Functions as antagonist for Myo31DF, an unconventional myosin with an essential role in the establishment of body left-right asymmetry (PubMed:16598258, PubMed:18521948, PubMed:22491943, PubMed:25659376, PubMed:30467170). (UniProtKB:Q23979)" FBgn0011361 UniProtKB "Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity). (UniProtKB:Q94519)" FBgn0010786 Alliance "Predicted to enable hydroxymethylbilane synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval central nervous system; gland; gut section; and nephrocyte. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase)." FBgn0029514 Alliance Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in negative regulation of ribosome biogenesis and negative regulation of translation. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to human MALSU1 (mitochondrial assembly of ribosomal large subunit 1). FBgn0003295 FlyBase Gene Snapshot "roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye." FBgn0052330 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052328 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052329 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011851 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011852 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011853 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052324 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052320 Alliance Predicted to be located in membrane. Orthologous to human DCST2 (DC-STAMP domain containing 2). FBgn0011854 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011855 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035216 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0035217 Alliance Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in membrane. Is expressed in adult head. FBgn0004635 FlyBase Gene Snapshot "rhomboid (rho) encodes an intra-membrane serine protease that processes the membrane precursors of Egfr ligands. Its roles include growth regulation, cell survival and developmental patterning." FBgn0028567 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. Is expressed in primary spermatocyte and spermatozoon. FBgn0035227 FlyBase Gene Snapshot "Increased minichromosome loss 1 (Iml1) encodes a component of the highly conserved GAP Activity Towards Rags 1 (GATOR1) complex, which inhibits the activity of the product of mTor in response to amino acid starvation. The product of Iml1, as well as the other GATOR1 components encoded by Nprl2 and Nprl3, regulates early meiotic progression." FBgn0011204 UniProtKB "Has a role in spermatogenesis and oogenesis (PubMed:8244010). Might have a role in triglyceride homeostasis (PubMed:25409104). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104). (UniProtKB:Q95RU0)" FBgn0028577 FlyBase Gene Snapshot "half pint (hfp) encodes a single stranded nucleic acid binding protein with roles in transcription and RNA splicing. It functions in Myc transcriptional repression and cell growth control, via interaction with the transcription factor encoded by hay." FBgn0043458 UniProtKB Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. (UniProtKB:Q9W0E8) FBgn0020248 FlyBase Gene Snapshot stem cell tumor (stet) encodes a gonad-specific intra-membrane protease of the rhomboid family that activates ligands of the product of Egfr. FBgn0052319 Alliance Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be part of NatC complex. FBgn0043865 FlyBase Gene Snapshot Stromalin 2 (SA2) encodes a paralog of the cohesin protein encoded by SA1. It functions in the male meiosis-specific homolog pairing pathway. It is required to maintain homolog pairing and to ensure bi-orientation of homologs during meiosis I. FBgn0035213 UniProtKB "Required for rDNA copy number maintenance and non-random sister chromatid segregation (NRSS) following unequal sister chromatid exchange (PubMed:35895823). Binds ribosomal DNA (rDNA) preferentially binding to intergenic spacers (IGS) regions on both X and Y chromosomes (PubMed:35895823). Essential for NRSS, a mechanism which contributes to the recovery and maintenance of inherently unstable rDNA copy numbers so that the integrity of the germline genome is upheld over generations and germline immortality is sustained (PubMed:35895823). May be involved in transcriptional regulation (Probable). (UniProtKB:Q8IRH5)" FBgn0035211 Alliance Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. FBgn0035210 UniProtKB "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. (UniProtKB:Q9W0G6)" FBgn0035208 Alliance "Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; embryonic dorsal epidermis; embryonic ventral epidermis; and embryonic/larval corpus cardiacum." FBgn0035206 FlyBase Gene Snapshot "sturkopf (sturkopf) encodes an evolutionary conserved lipid droplet-associated protein. In the absence of lipid droplets, the protein localizes to the endoplasmic reticulum." FBgn0035204 Alliance Predicted to enable 5'-nucleotidase activity. Is expressed in organism. Orthologous to human NT5DC1 (5'-nucleotidase domain containing 1). FBgn0010333 FlyBase Gene Snapshot "Rac1 (Rac1) encodes a GTPase signaling protein that acts as a molecular switch, regulating cell shape, movement, division, and wound healing. It responds to signals from RTK and PIP3 pathways, activating the WAVE regulatory complex. This promotes the formation of branched actin filaments, helping cells move and change shape." FBgn0035194 FlyBase Gene Snapshot "Psf1 (Psf1) encodes a subunit of the Cdc45/Mcm2-7/GINS (CMG) complex, which is associated with an ATP-dependent DNA helicase function and is involved in the regulation of the mitotic G1/S transition." FBgn0052318 Alliance Predicted to enable ATP binding activity and microtubule binding activity. Predicted to be involved in microtubule-based movement. FBgn0004378 FlyBase Gene Snapshot Kinesin-like protein at 61F (Klp61F) encodes a member of the kinesin-5 family of cytoskeletal motor proteins. It allows the crosslinking and sliding apart of adjacent microtubules. This 'sliding filament mechanism' is critical for many aspect of mitosis and chromosome segregation. FBgn0035193 Alliance Is expressed in sensory nervous system primordium. FBgn0035229 Alliance Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 49. Orthologous to several human genes including DENND5B (DENN domain containing 5B). FBgn0041342 FlyBase Gene Snapshot Phosphocholine cytidylyltransferase 1 (Pcyt1) encodes a choline-phosphate cytidylyltransferase involved in the endosomal traffic of several protein including the products of Egfr and N. FBgn0035231 Alliance "Enables choline-phosphate cytidylyltransferase activity. Predicted to be involved in CDP-choline pathway. Located in cytoplasm. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to several human genes including PCYT1A (phosphate cytidylyltransferase 1A, choline)." FBgn0035233 FlyBase Gene Snapshot Peroxin 10 (Pex10) encodes a peroxisome protein important for sperm development. FBgn0035236 Alliance "Predicted to enable carbohydrate binding activity. Involved in defense response to fungus and synaptic target recognition. Predicted to be active in membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to several human genes including TMEM184B (transmembrane protein 184B)." FBgn0035237 Alliance Is expressed in adult head; male germline cell; and somatic cell of testis. Orthologous to human BTBD8 (BTB domain containing 8). FBgn0035244 FlyBase Gene Snapshot "ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis." FBgn0053230 Alliance Predicted to enable histone H3K36 methyltransferase activity; histone H3K4 methyltransferase activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Orthologous to human SETD4 (SET domain containing 4). FBgn0013753 FlyBase Gene Snapshot "Big brother (Bgb) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bro in embryonic segmentation." FBgn0035248 Alliance Orthologous to human TMEM60 (transmembrane protein 60). FBgn0013755 FlyBase Gene Snapshot "Brother (Bro) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bgb in embryonic segmentation." FBgn0025712 Alliance "Predicted to be involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic central brain neurons; and ganglia. Orthologous to human TMEM35A (transmembrane protein 35A)." FBgn0035252 Alliance "Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Orthologous to human PXMP2 (peroxisomal membrane protein 2)." FBgn0035254 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Is expressed in organism. Orthologous to human C9orf78 (chromosome 9 open reading frame 78)." FBgn0035257 Alliance Is expressed in amnioserosa; amnioserosa primordium; and apoptotic amnioserosa. FBgn0035260 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval central nervous system; and embryonic/larval pericardial cell." FBgn0035263 Alliance Is expressed in adult head. FBgn0035266 Alliance Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase); GK2 (glycerol kinase 2); and GK3 (glycerol kinase 3). FBgn0035267 Alliance Is expressed in organism. FBgn0035268 Alliance "Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8); DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1); and DCAF8L2 (DDB1 and CUL4 associated factor 8 like 2)." FBgn0027903 UniProtKB "Accessory component of both the DNA polymerase delta complex and possibly the DNA polymerase zeta complex (By similarity). As a component of the delta complex, participates in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Appears to promote the function of the DNA pol-delta complex accessory subunit PolD3 in both embryonic and postembryonic somatic cells (PubMed:31100062). (UniProtKB:Q9W088)" FBgn0035272 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; embryonic/larval muscle system; gut section; and trunk mesoderm. Orthologous to human MRPL46 (mitochondrial ribosomal protein L46)." FBgn0011573 FlyBase Gene Snapshot Cell division cycle 37 (Cdc37) encodes a putative chaperone that inhibits Wnt and Hh signaling pathways. FBgn0035273 Alliance Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Is expressed in eye and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). FBgn0067864 FlyBase Gene Snapshot "Patj (Patj) encodes a PDZ domain-protein that forms an apical protein complex with the products of crb and sdt. It plays supporting roles in apico-basal cell polarity and stability of adherens junction. It is also involved in retinal morphogenesis, maintenance, and planar cell polarity." FBgn0027790 FlyBase Gene Snapshot GV1 (GV1) encodes a protein with foci that are observed in interphase nuclei and often associated with nuclear periphery. FBgn0035280 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head sensory system; embryonic ventral epidermis; and sensory nervous system primordium." FBgn0035279 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0025820 Alliance Predicted to be involved in mitotic cytokinesis. Predicted to be located in membrane. Predicted to be active in cytoplasm and midbody. Predicted to colocalize with centrosome and spindle. Is expressed in adult head and organism. Orthologous to human JTB (jumping translocation breakpoint). FBgn0024510 FlyBase Gene Snapshot discs lost (dlt) encodes a protein required for cell survival and cell cycle progression in imaginal discs. FBgn0035271 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in embryonic/larval central nervous system; embryonic/larval lymph gland; embryonic/larval salivary gland; eye disc; and larval ventral nerve cord. Orthologous to human LSM8 (LSM8 homolog, U6 small nuclear RNA associated)." FBgn0035270 Alliance Predicted to be involved in intracellular signal transduction. Is expressed in organism and pole plasm. FBgn0013811 FlyBase Gene Snapshot Dynein heavy chain at 62B (Dhc62B) encodes a motor protein involved in retrograde axonal transport. FBgn0022702 Alliance "Predicted to enable chitin binding activity and chitinase activity. Involved in chitin-based cuticle development; ecdysis, chitin-based cuticle; and wound healing. Located in extracellular space. Is expressed in several structures, including adult head; embryonic head epidermis; epidermis; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic)." FBgn0035265 Alliance Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in membrane. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). FBgn0035264 Alliance "Involved in cilium assembly and positive regulation of canonical Wnt signaling pathway. Located in non-motile cilium. Is expressed in several structures, including Malpighian tubule primordium; antenno-maxillary complex; epithelium; gut section; and sensory organ cell. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35)." FBgn0027594 FlyBase Gene Snapshot "draper (drpr) encodes a single-pass transmembrane receptor that is involved in phagocytosis by glia, macrophages, and epithelia. It signals downstream through the proteins encoded by Src42A and Shark to promote Rac1 function and transcriptional changes through the products of Jra and Stat92E. It is also required for activation of autophagy in salivary glands." FBgn0035262 Alliance Predicted to be involved in epigenetic regulation of gene expression and response to DNA damage checkpoint signaling. Predicted to be located in nucleus. FBgn0035256 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement. Predicted to be part of axonemal dynein complex. Is expressed in chordotonal neurons. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). FBgn0035255 Alliance "Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in Rab protein signal transduction and vesicle-mediated transport. Located in synapse. Is expressed in adult head; eye photoreceptor cell; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in orofaciodigital syndrome. Orthologous to human RAB34 (RAB34, member RAS oncogene family) and RAB36 (RAB36, member RAS oncogene family)." FBgn0026372 FlyBase Gene Snapshot Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis. FBgn0035251 Alliance Predicted to enable ATPase activator activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be part of ESCRT IV complex. Predicted to be active in multivesicular body. Is expressed in adult head and organism. Orthologous to human VTA1 (vesicle trafficking 1). FBgn0035249 Alliance Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in papillary renal cell carcinoma. Orthologous to human PRCC (proline rich mitotic checkpoint control factor). FBgn0025725 Alliance "Predicted to enable structural molecule activity. Involved in male meiosis cytokinesis; protein localization to cleavage furrow; and regulation of lipid storage. Located in endoplasmic reticulum-Golgi intermediate compartment. Part of COPI vesicle coat. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; male germline cell; and mesoderm. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha)." FBgn0035247 UniProtKB Probable methyltransferase. (UniProtKB:Q86BS6) FBgn0013342 FlyBase Gene Snapshot neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. FBgn0035245 FlyBase Gene Snapshot gamma-glutamyl carboxylase (GC) encodes an enzyme involved in peptidyl-glutamic acid carboxylation. FBgn0035246 Alliance "Involved in negative regulation of translation and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; ganglia; and sensory nervous system primordium." FBgn0035243 Alliance Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). FBgn0035238 FlyBase Gene Snapshot CG12104 encodes a HMG-box containing protein expressed in the spermatogonia and spermatocytes. FBgn0035235 Alliance "Predicted to enable mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in schizophrenia 19. Orthologous to human RBM12 (RNA binding motif protein 12) and RBM12B (RNA binding motif protein 12B)." FBgn0035232 Alliance Predicted to enable transcription cis-regulatory region binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein autoubiquitination. Is expressed in organism. Orthologous to human RNF10 (ring finger protein 10). FBgn0052313 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). FBgn0035228 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic anal pad; embryonic/larval midgut primordium; and mesoderm. Orthologous to human PPTC7 (protein phosphatase targeting COQ7)." FBgn0035283 Alliance Predicted to enable ubiquitin binding activity. Is expressed in organism. Orthologous to human CUEDC1 (CUE domain containing 1). FBgn0035285 Alliance Is expressed in adult head and organism. Orthologous to human TMEM134 (transmembrane protein 134). FBgn0035286 Alliance Predicted to enable microtubule binding activity. FBgn0052312 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035294 UniProtKB Required for pre-mRNA splicing. (UniProtKB:Q9W062) FBgn0035295 FlyBase Gene Snapshot "Centrobin (Cnb) encodes a protein that localizes to the daughter centriole. In neuroblasts, its centriolar localization results in peri-centriolar material retention during interphase. This function requires the phosphorilation of the product of Cnb by the kinase encoded by polo. In the neurons of type I sensory organs, the product of Cnb is necessary and sufficient to inhibit basal body function." FBgn0035298 UniProtKB Key enzyme for ketone body catabolism (PubMed:24100554). Transfers the CoA moiety from succinate to acetoacetate (PubMed:24100554). Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). (UniProtKB:Q9W058) FBgn0035300 UniProtKB "Amino acid transporter which has pH-dependent electrogenic transport activity for alanine, glycine and proline (PubMed:15843412). Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197). (UniProtKB:Q9W056)" FBgn0035299 Alliance Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. FBgn0027547 Alliance Is expressed in embryonic/larval midgut and organism. FBgn0002872 FlyBase Gene Snapshot mutator 2 (mu2) encodes an androgen receptor co-activator involved in double-strand break repair and regulation of chromatin organization. FBgn0035293 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0035290 FlyBase Gene Snapshot debris buster (dsb) encodes a double-span transmembrane protein of the CD36 family residing in late endosomes and lysosomes. It is required for late stage phagosome maturation. FBgn0035287 Alliance Predicted to enable sulfotransferase activity. Predicted to be involved in carbohydrate biosynthetic process. Predicted to be located in membrane. Is expressed in adult fat body; embryonic/larval fat body; organism; and wing disc. Orthologous to human CHST10 (carbohydrate sulfotransferase 10) and CHST8 (carbohydrate sulfotransferase 8). FBgn0042712 FlyBase Gene Snapshot "HBS1 (HBS1) encodes an elongation factor class G protein that is implicated in messenger RNA quality control, by forming a protein complex with the product of pelo to promote decay of mRNAs with ribosomal stalls." FBgn0004636 FlyBase Gene Snapshot "Rap1 GTPase (Rap1) encodes a small GTPase in the Ras superfamily. When GTP-bound, it binds to a number of different effectors, one of which is the product of cno. Together they regulate many morphogenetic movements, including mesoderm invagination and dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs." FBgn0035282 FlyBase Gene Snapshot CNMamide (CNMa) encodes a short signaling peptide that shows a potent agonist activity toward the G-protein coupled receptor encoded by CNMaR. FBgn0035281 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic head epidermis; epidermis; and gut section." FBgn0035315 Alliance "Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal ectoderm anlage; foregut anlage; and mesoderm." FBgn0035317 UniProtKB Required for the maintenance and formation of cilia. (UniProtKB:Q9W040) FBgn0040507 Alliance "Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cAMP biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; germline cell; and gonad. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7)." FBgn0052301 Alliance Predicted to enable adenylate cyclase activity. Involved in chaeta development and notum development. Predicted to be active in plasma membrane. FBgn0052305 Alliance Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cAMP biosynthetic process. Predicted to be active in plasma membrane. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). FBgn0015359 Alliance Predicted to contribute to tRNA binding activity. Predicted to be involved in tRNA modification. Part of elongator holoenzyme complex. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). FBgn0035323 Alliance Predicted to enable RNA binding activity. Predicted to be involved in RNA 5'-cap (guanine-N7)-methylation. Predicted to be part of mRNA capping enzyme complex. FBgn0035325 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic Malpighian tubule; embryonic proventriculus; and embryonic proventriculus inner layer. FBgn0052304 Alliance Predicted to enable chitin binding activity. Predicted to be located in chitin-based extracellular matrix. FBgn0052302 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic proventriculus and embryonic/larval posterior spiracle. FBgn0052303 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035328 Alliance Predicted to be active in extracellular region. FBgn0035332 Alliance Predicted to enable monoatomic ion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein). FBgn0035334 Alliance Predicted to enable protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Predicted to be active in mitochondrion. Is expressed in adult heart and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). FBgn0035336 Alliance Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be active in nucleolus. Is expressed in spermatozoon. Orthologous to human NOM1 (nucleolar protein with MIF4G domain 1). FBgn0052298 Alliance Is expressed in organism. FBgn0052299 Alliance Is expressed in organism. FBgn0035337 Alliance Orthologous to human C7orf50 (chromosome 7 open reading frame 50). FBgn0035335 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Orthologous to human MRPL23 (mitochondrial ribosomal protein L23)." FBgn0035333 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in ERAD pathway and protein ubiquitination. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). FBgn0041709 Alliance Predicted to be active in extracellular region. FBgn0000543 FlyBase Gene Snapshot "ecdysoneless (ecd) encodes a protein that physically interacts with several components of the U5 snRPN pre-mRNA splicing complex. Its loss result in intron retention within spok, accounting for ecdysone deficiency of some ecd mutants." FBgn0015360 FlyBase Gene Snapshot "peptide O-xylosyltransferase (oxt) encodes an enzyme that catalyzes the first xylose of the linkage region of glycosaminoglycan (GAG). Through GAG synthesis, the product of oxt is involved in several signaling pathways mediated by GAGs in development." FBgn0035321 Alliance Predicted to enable transmembrane ascorbate ferrireductase activity. Is expressed in adult head; adult heart; embryonic/larval central nervous system; l-LNv neurons; and organism. Orthologous to several human genes including CYBRD1 (cytochrome b reductase 1). FBgn0035318 Alliance Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Is expressed in adult head and organism. Orthologous to several human genes including RPRD1B (regulation of nuclear pre-mRNA domain containing 1B). FBgn0026593 Alliance Enables serine hydrolase activity. Is expressed in adult head and organism. Orthologous to human SERHL2 (serine hydrolase like 2). FBgn0035312 Alliance Predicted to enable hydrolase activity. Orthologous to human SERHL (serine hydrolase like (pseudogene)) and SERHL2 (serine hydrolase like 2). FBgn0026570 Alliance Predicted to enable hydrolase activity. Is expressed in organism. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). FBgn0035309 Alliance Predicted to enable hydrolase activity. Orthologous to human SERHL (serine hydrolase like (pseudogene)) and SERHL2 (serine hydrolase like 2). FBgn0035308 Alliance "Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Orthologous to human SESTD1 (SEC14 and spectrin domain containing 1)." FBgn0035346 Alliance "Is expressed in several structures, including anterior endoderm; embryonic leading edge cell primordium; embryonic/larval midgut primordium; gnathal primordium; and larval foregut atrium." FBgn0016794 UniProtKB "Essential component for signaling from various receptor tyrosine kinases such as Sevenless, TORSO and DER. Required for photoreceptor cell and wing development. (UniProtKB:Q9VZZ9)" FBgn0062517 Alliance "Predicted to enable calmodulin binding activity. Predicted to be active in acrosomal vesicle. Is expressed in dorsal sensory complex proper primordium; embryonic head sensory system; sensory nervous system primordium; spermatozoon; and ventral sensory complex primordium. Orthologous to human ENKUR (enkurin, TRPC channel interacting protein)." FBgn0035355 Alliance Predicted to enable fatty acyl-CoA hydrolase activity. Is expressed in adult head; adult heart; and organism. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). FBgn0035356 Alliance Predicted to enable fatty acyl-CoA hydrolase activity. Is expressed in adult head. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). FBgn0035357 FlyBase Gene Snapshot MEP-1 (MEP-1) encodes a zinc finger protein that associates with the ATP-dependent nucleosome remodeler encoded by Mi-2. It cooperates with the product of Mi-2 in the repression of cell type-specific genes. FBgn0035360 Alliance Is expressed in adult head and embryonic/larval midgut. FBgn0053233 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. FBgn0053234 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human SVOPL (SVOP like). FBgn0020509 FlyBase Gene Snapshot Accessory gland protein 62F (Acp62F) encodes a trypsin inhibitor that is synthesized in male accessory glands and transferred to females during mating. It influences sperm storage in mated females. FBgn0052296 FlyBase Gene Snapshot "Myocardin-related transcription factor (Mrtf) encodes a protein that binds to the product of bs, and likely other transcription factors, to enhance downstream gene activation. The activity of the product of Mrtf is regulated by free actin levels. It contributes to tracheal branching, border cell migration, and other cell stretching and invasive migration processes during development." FBgn0027082 Alliance "Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial)." FBgn0011828 UniProtKB "Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (PubMed:22842973). Plays a role in extracellular matrix consolidation, phagocytosis and defense (PubMed:8062820). (UniProtKB:Q9VZZ4)" FBgn0028504 Alliance Is expressed in wing disc. FBgn0010909 FlyBase Gene Snapshot misshapen (msn) encodes a Sterile 20 MAP kinase kinase kinase. FBgn0010905 FlyBase Gene Snapshot Spinophilin (Spn) encodes a scaffold protein protein that regulates the neurexin/neuroligin signalling at the presynaptic active zone. FBgn0035348 Alliance "Predicted to enable purine-nucleoside phosphorylase activity. Involved in imaginal disc fusion, thorax closure. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase)." FBgn0035344 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9W011) FBgn0035370 Alliance Located in nucleolus. Is expressed in embryonic brain and organism. FBgn0044452 FlyBase Gene Snapshot Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy. FBgn0035374 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head and adult heart. Orthologous to human MRPS35 (mitochondrial ribosomal protein S35). FBgn0035375 UniProtKB "Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (PubMed:12829714). In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:12829714). Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (PubMed:12829714). Prefers the diglycosylated Muc5AC-3/13 as substrate (PubMed:12829714). Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure (PubMed:20807760). (UniProtKB:Q6WV16)" FBgn0035382 FlyBase Gene Snapshot Odorant receptor 63a (Or63a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0035383 FlyBase Gene Snapshot Carnitine palmitoyltransferase 2 (CPT2) encodes an enzyme required for the beta-oxidation of long-chain fatty acids. FBgn0035384 Alliance Predicted to enable actin binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in actin cytoskeleton. Orthologous to human ABRA (actin binding Rho activating protein). FBgn0035385 FlyBase Gene Snapshot "FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light." FBgn0035388 Alliance "Predicted to enable nucleic acid binding activity. Is expressed in several structures, including adult antennal lobe local neurons; antennal anlage; anterior endoderm; central brain anlage; and embryonic/larval midgut primordium. Orthologous to several human genes including R3HCC1L (R3H domain and coiled-coil containing 1 like)." FBgn0040308 FlyBase Gene Snapshot Peroxiredoxin 4 (Prx4) encodes an atypical 2-Cys peroxiredoxin that regulates hydrogen peroxide levels and participates in the formation of disulfide bonds during oxidative protein folding. FBgn0052485 Alliance Enables small GTPase binding activity. Predicted to be involved in phospholipid transport. Located in Golgi apparatus. FBgn0035392 Alliance Predicted to be involved in glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human GK5 (glycerol kinase 5). FBgn0035393 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human SLX9 (SLX9 ribosome biogenesis factor)." FBgn0035397 UniProtKB "Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. (UniProtKB:Q95RR8)" FBgn0035390 FlyBase Gene Snapshot "scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis." FBgn0004372 FlyBase Gene Snapshot always early (aly) encodes a key protein in males both for the onset of spermatid differentiation and for G2-meiosis I transition. FBgn0052487 Alliance Predicted to enable phosphatase activity. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). FBgn0052488 Alliance Predicted to enable phosphatase activity. Predicted to be active in cytoplasm. Is expressed in adult head; organism; and spermatozoon. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). FBgn0035379 UniProtKB "Neurotrophin which may function as a ligand for the Toll-related receptors Toll-6 and Toll-7 (PubMed:23892553). Binds to Toll-7 and Toll-6, and probably acts as their ligands in the promotion of motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:19018662, PubMed:23892553). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons (PubMed:19018662). May be involved in the normal development of specific neurons at the neuromuscular junction (PubMed:24124519). (UniProtKB:Q9VZX1)" FBgn0035372 Alliance Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human TP53I13 (tumor protein p53 inducible protein 13). FBgn0035371 FlyBase Gene Snapshot "Adenosylhomocysteinase like 1 (AhcyL1) encodes a protein that, together with the product of AhcyL2, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and production of deoxyribonucleotides." FBgn0003938 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0052288 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052289 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052287 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052285 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052286 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035401 Alliance "Predicted to enable alpha-1,3-mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval salivary gland; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase)." FBgn0035405 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain anlage; central brain primordium; ganglia; gonad; and ventral nerve cord primordium." FBgn0024194 FlyBase Gene Snapshot rasp (rasp) encodes an acyltransferase enzyme that adds essential N-terminal palmitate modifications to the secreted signaling domains of the products of hh and spi. The modification of the product of spi appears to increase the local concentration of the ligand by restricting its diffusion. FBgn0052280 Alliance Predicted to enable zinc ion binding activity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to several human genes including CDIP1 (cell death inducing p53 target 1). FBgn0052278 Alliance "Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic anal pad; embryonic/larval midgut primordium; gut section; and mesoderm." FBgn0052281 UniProtKB "Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. (UniProtKB:Q8IRE4)" FBgn0052284 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035412 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0001233 UniProtKB "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins. (UniProtKB:P02828)" FBgn0035421 Alliance "Predicted to enable sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process; sphingolipid catabolic process; and sphingomyelin metabolic process. Predicted to be active in caveola and endoplasmic reticulum. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and mesoderm. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2)." FBgn0035423 UniProtKB Probably involved in translation. (UniProtKB:Q9VZS3) FBgn0035424 FlyBase Gene Snapshot La-related protein 4B (Larp4B) encodes a member of the LARP family of RNA-binding proteins. It has been shown to post-transcriptionally inhibit the expression of the protein encoded by Myc and negatively regulate cell growth. FBgn0035427 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035428 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; and gut section." FBgn0035429 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0035430 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic/larval tracheal dorsal trunk; embryonic/larval visceral tracheal branch; and tracheal primordium. FBgn0035432 FlyBase Gene Snapshot Zinc transporter 63C (ZnT63C) encodes a plasma membrane resident zinc transporter belonging to the zinc transporter family that is mainly responsible for zinc export from the cell or into organelles. It plays a key role in effluxing zinc from enterocytes into circulation during dietary zinc absorption. FBgn0052279 FlyBase Gene Snapshot Drosomycin-like 2 (Drsl2) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. FBgn0052283 FlyBase Gene Snapshot Drosomycin-like 3 (Drsl3) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. It is expressed in the gut under the control of the JAK-STAT pathway. FBgn0052282 FlyBase Gene Snapshot Drosomycin-like 4 (Drsl4) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. FBgn0035434 FlyBase Gene Snapshot Drosomycin-like 5 (Drsl5) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. FBgn0035436 Alliance Predicted to enable ribosylnicotinamide kinase activity. Predicted to be involved in nicotinamide riboside metabolic process. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including NMRK2 (nicotinamide riboside kinase 2). FBgn0035438 FlyBase Gene Snapshot Glutathione peroxidase homolog with thioredoxin peroxidase activity (Gtpx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress. FBgn0004167 FlyBase Gene Snapshot "karst (kst) encodes a protein that, together with the product of alpha-Spec, crosslinks F-actin and acts as a molecular scaffold. It is recruited to the apical membrane of epithelial cells by the apical determinant encoded by crb. The roles of the product of kst include endosomal trafficking, cell adhesion, cell signaling and growth control." FBgn0035443 Alliance Predicted to enable ATP hydrolysis activity. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human AFG2B (AFG2 AAA ATPase homolog B). FBgn0035444 Alliance Orthologous to human BRI3 (brain protein I3). FBgn0035445 Alliance Enables iduronate-2-sulfatase activity. Predicted to be involved in glycosaminoglycan catabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in mucopolysaccharidosis II. Orthologous to human IDS (iduronate 2-sulfatase). FBgn0027616 FlyBase Gene Snapshot YTH domain containing 1 (Ythdc1) encodes a pre-mRNA binding protein involved in the regulation of mRNA alternative splicing and sex determination. FBgn0052268 FlyBase Gene Snapshot Drosomycin-like 6 (Drsl6) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. FBgn0052274 Alliance Involved in defense response to fungus. Predicted to be located in extracellular region. FBgn0035440 Alliance Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 5. Orthologous to human OSTM1 (osteoclastogenesis associated transmembrane protein 1). FBgn0035437 FlyBase Gene Snapshot "Striatin interacting protein (Strip) encodes an intracellular protein and component of the STRIPAK PP2A protein complex. It is involved in Hippo signaling, endosome maturation, and microtubule regulation." FBgn0035435 FlyBase Gene Snapshot "Phosphatidylinositol glycan anchor biosynthesis class C (PIG-C) encodes a subunit of GPI-GlcNAc transferase, which catalyzes the first reaction in the biosynthesis of the glycosylphosphatidylinositol (GPI)-anchor." FBgn0035431 Alliance "Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; embryonic head sensory system; sense organ; and sensory nervous system primordium." FBgn0035425 Alliance Predicted to enable phosphoprotein phosphatase activity. Predicted to be located in cytosol. Is expressed in adult head and organism. FBgn0035422 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Orthologous to human RPL28 (ribosomal protein L28). FBgn0035420 UniProtKB "Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. (UniProtKB:Q9VZS7)" FBgn0053160 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0052277 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0053159 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0052271 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0047135 Alliance "Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including anterior endoderm; embryonic head epidermis; embryonic ventral epidermis; epithelium; and mesoderm. Orthologous to human SERP1 (stress associated endoplasmic reticulum protein 1) and SERP2 (stress associated endoplasmic reticulum protein family member 2)." FBgn0035415 Alliance Predicted to be active in cytoplasm. Is expressed in head mesoderm; organism; and trunk mesoderm. Orthologous to human C15orf40 (chromosome 15 open reading frame 40). FBgn0035414 Alliance Is expressed in organism. FBgn0035410 Alliance Involved in sarcomere organization. Predicted to be active in M band. Is expressed in adult head; adult heart; and adult somatic muscle cell. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); lethal congenital contracture syndrome 4; and muscle tissue disease (multiple). Orthologous to human MYBPC1 (myosin binding protein C1); MYBPC2 (myosin binding protein C2); and MYBPC3 (myosin binding protein C3). FBgn0035409 Alliance Is expressed in adult anterior Malpighian tubule. FBgn0035407 FlyBase Gene Snapshot "ASCIZ zinc finger protein (Asciz) encodes a transcription factor that regulates the expression of ctp, which encodes a LC8 dynein light chain. The product of Asciz is involved in dynein motor functions, including mitotic chromosome segregation, and dynein-independent functions, such as patterning of cell cycles and apoptosis during development." FBgn0035402 FlyBase Gene Snapshot "Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis." FBgn0035400 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval salivary gland body; and gut section. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A) and MFSD14B (major facilitator superfamily domain containing 14B)." FBgn0026189 Alliance Involved in microvillus organization. Is active in apical plasma membrane. Is expressed in adult head; embryonic/larval brain; fat body; and spermatozoon. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1) and PROM2 (prominin 2). FBgn0052273 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035398 FlyBase Gene Snapshot "Chitinase 7 (Cht7) encodes an enzyme involved in cuticle development, ecdysis and wound healing." FBgn0052272 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0005640 FlyBase Gene Snapshot "Ecdysone-induced protein 63E (Eip63E) encodes a cyclin-dependent kinase that interacts with the product of CycY. It contributes to embryogenesis, larval development and metamorphosis." FBgn0035452 Alliance "Predicted to enable G protein-coupled receptor binding activity and chitin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including dorsal head epidermis; embryonic hypopharynx; embryonic salivary gland duct; embryonic/larval glial cell; and ganglia. Orthologous to human TNR (tenascin R)." FBgn0035453 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0035455 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Involved in sexual reproduction. Located in extracellular space. FBgn0001254 UniProtKB "Probably has an essential role in embryogenesis, induces morphogenesis of imaginal disks, and may participate in multimolecular aggregates. (UniProtKB:P29681)" FBgn0052267 Alliance Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein targeting to mitochondrion. Part of mitochondrial outer membrane translocase complex. Is active in mitochondrial outer membrane. Is expressed in adult heart. FBgn0035449 Alliance Predicted to enable antiporter activity. Predicted to be involved in UDP-glucose transmembrane transport. Located in Golgi trans cisterna. Is expressed in adult head. Orthologous to human SLC35C2 (solute carrier family 35 member C2). FBgn0026259 Alliance Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Is expressed in adult brain cell body rind and adult head. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). FBgn0014388 UniProtKB "Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells. (UniProtKB:O44783)" FBgn0035462 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). May be involved in the 3'-end processing of the spliceosomal snRNAs U1, U2, U4 and U5 but is probably not essential for 3'-end processing of the snRNA U7 (PubMed:21078872, PubMed:23097424). (UniProtKB:Q9VZM7)" FBgn0035464 UniProtKB "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity). (UniProtKB:Q9VZM5)" FBgn0004888 UniProtKB "Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (UniProtKB:Q94522)" FBgn0004875 FlyBase Gene Snapshot "encore (enc) encodes a protein involved in the regulation of germline mitoses. It promotes the upregulation of grk mRNA translation in the dorsal anterior corner of the oocyte, allowing normal dorso-ventral pattern formation." FBgn0013751 FlyBase Gene Snapshot Arrowhead (Awh) encodes a LIM-homeodomain transcription factor that plays important roles in wing and abdominal development. FBgn0026592 FlyBase Gene Snapshot Fire exit (Fie) is expressed in some peripheral glia cells and encodes a transmembrane protein that may be involved in intracellular transport during glial development. FBgn0035469 UniProtKB "Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. (UniProtKB:Q9VZL6)" FBgn0035471 Alliance "Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in very long-chain fatty acid biosynthetic process. Located in cytoplasm and endomembrane system. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14 and catecholaminergic polymorphic ventricular tachycardia 3. Orthologous to several human genes including TECR (trans-2,3-enoyl-CoA reductase)." FBgn0041147 FlyBase Gene Snapshot imaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition. FBgn0004910 FlyBase Gene Snapshot "Ecdysone-induced protein 63F 1 (Eip63F-1) encodes a member of the EF-hand family of Ca[2+]-binding proteins, induced directly by 20-hydroxyecdysone in late third instar larvae. It is responsible for formation of the 63F early puff in the polytene chromosomes." FBgn0035473 FlyBase Gene Snapshot "maggie (mge) encodes a protein predicted to act as a receptor of the TOM (translocase of outer membrane) complex, which is involved in protein import into mitochondria. The product of mge modulates cell death induced by the expression of the mouse Bax protein." FBgn0035470 FlyBase Gene Snapshot "Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes." FBgn0035468 FlyBase Gene Snapshot "Gustatory receptor 63a (Gr63a) encodes a transmembrane domain protein unrelated to GPCRs. Together with the product Gr21a, it forms a heteromultimeric receptor for carbon dioxide, an important chemosensory cue for insects." FBgn0015585 FlyBase Gene Snapshot Accessory gland protein 63F (Acp63F) encodes a protein produced by the male accessory glands and transferred to females during mating. FBgn0052263 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in mitochondrial ribosome assembly and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). FBgn0052262 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in mitochondrial ribosome assembly and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). FBgn0035461 UniProtKB Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability. (UniProtKB:Q8SX86) FBgn0052264 Alliance Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in cytosol and nucleus. Is expressed in adult brain; anterior midgut primordium; embryonic/larval midgut; and posterior midgut primordium. Human ortholog(s) of this gene implicated in Parkinson's disease; artery disease (multiple); brain disease (multiple); and multiple sclerosis. Orthologous to several human genes including PHACTR1 (phosphatase and actin regulator 1). FBgn0035458 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0035490 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic head epidermis; embryonic head sensory system; embryonic hindgut; embryonic ventral epidermis; and epidermis. FBgn0042179 Alliance Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Orthologous to several human genes including UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus); UGT2A2 (UDP glucuronosyltransferase family 2 member A2); and UGT2A3 (UDP glucuronosyltransferase family 2 member A3). FBgn0000449 FlyBase Gene Snapshot "disembodied (dib) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 22 carbon of the cholesterol side chain. dib mutants fail to undergo head involution, dorsal closure and to secrete cuticle." FBgn0035495 Alliance Is expressed in embryonic brain; larval ventral nerve cord; and ventral nerve cord primordium. FBgn0035496 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0035498 UniProtKB Probably involved in cell adhesion. (UniProtKB:Q9VZI3) FBgn0028484 UniProtKB "Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in diverse biological functions such as cell survival, cell differentiation, cell growth and proliferation (PubMed:11997505, PubMed:18816840, PubMed:22615583, PubMed:23562806, PubMed:25223282, PubMed:27462444). Phosphorylates SH3PX1 and ex (PubMed:11773052, PubMed:22615583, PubMed:27462444). Phosphorylates SH3PX1 predominantly on 'Tyr-56', which likely promotes the recruitment of SH3PX1 to an axonal guidance receptor complex that includes dock and Dscam; because phosphorylation of SH3PX1 increases its interaction with the complex member dock while decreasing its interaction with the actin cytoskeleton modulator WASp (PubMed:11773052). In the wing and eye, promotes tissue growth, and during embryogenesis coordinates cell shape changes required for correct dorsal closure (PubMed:18816840, PubMed:22615583, PubMed:27462444). Functions in the negative regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway by enhancing yki activity thereby promoting cell proliferation and inhibiting apoptosis (PubMed:22615583, PubMed:27462444). This is accomplished, at least in part, by phosphorylating ex thereby reducing its ability to efficiently activate the Hippo signaling cascade (PubMed:27462444). In the eye disk, wing disk and possibly spermatids, inhibits programmed cell death induced by hid and rpr through a mechanism that is independent of the MAP kinase signal transduction pathway (PubMed:22615583). Essential for male and female fertility (PubMed:22615583, PubMed:23562806). During oogenesis required for the correct temporal assembly, and consequently the catalytic activity of long Ctps filaments (cytoophidium) in the germline nurse cells, likely by phosphorylating an unidentified substrate that is essential for linking individual Ctps filaments into large, catalytically active assemblies (PubMed:25223282). (UniProtKB:Q9VZI2)" FBgn0003206 UniProtKB May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (UniProtKB:P04388) FBgn0004552 FlyBase Gene Snapshot Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body. FBgn0052260 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0035501 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic dorsal epidermis; embryonic/larval tracheal dorsal trunk; embryonic/larval tracheal section; and seminal receptacle. FBgn0040696 Alliance "Predicted to be involved in regulation of cilium movement. Is expressed in several structures, including embryonic head sensory system; embryonic labial sensory complex; embryonic maxillary sensory complex; sensory nervous system primordium; and ventral sensory complex anlage. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 26. Orthologous to human CFAP298 (cilia and flagella associated protein 298)." FBgn0003710 UniProtKB Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality. (UniProtKB:P48613) FBgn0035513 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in several structures, including adult head; adult heart; and epithelial tube." FBgn0035515 Alliance "Predicted to enable FAD binding activity; glutathione-dependent sulfide quinone oxidoreductase activity; and sulfide:quinone oxidoreductase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human SQOR (sulfide quinone oxidoreductase)." FBgn0011692 FlyBase Gene Snapshot "pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity." FBgn0035517 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in lysosomal membrane. Is expressed in adult head. Orthologous to human SLC66A3 (solute carrier family 66 member 3). FBgn0035519 Alliance "Enables serine hydrolase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Located in endomembrane system. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 86. Orthologous to human ABHD16A (abhydrolase domain containing 16A, phospholipase) and ABHD16B (abhydrolase domain containing 16B)." FBgn0035521 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase, V0 domain. Is expressed in adult head and ovariole. Orthologous to several human genes including ATP6V0E2 (ATPase H+ transporting V0 subunit e2)." FBgn0035522 Alliance "Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; gut section; and visceral mesoderm derivative." FBgn0035523 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to several human genes including SLC44A3 (solute carrier family 44 member 3). FBgn0035526 Alliance Predicted to enable mRNA binding activity. Is expressed in adult head and organism. Orthologous to human RBM45 (RNA binding motif protein 45). FBgn0015829 Alliance Predicted to contribute to TFIIH-class transcription factor complex binding activity. Involved in mRNA transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIE complex. Is expressed in organism. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). FBgn0041630 FlyBase Gene Snapshot Hexosaminidase 1 (Hexo1) encodes a beta-N-acetylglucosaminidase involved in protein deglycosylation and rhodopsin biosynthesis. FBgn0035529 FlyBase Gene Snapshot Ferredoxin 2 (Fdx2) encodes a protein involved in ecdysteroid biosynthesis regulation. FBgn0035528 Alliance "Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Is expressed in several structures, including adult head; adult heart; central brain primordium; ganglia; and larval imaginal tissue. Orthologous to human TMEM50A (transmembrane protein 50A) and TMEM50B (transmembrane protein 50B)." FBgn0035524 UniProtKB Required for biogenesis of the 60S ribosomal subunit. (UniProtKB:Q9VZE6) FBgn0035520 Alliance "Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U4/U6 x U5 tri-snRNP complex. Is expressed in organism. Orthologous to human ZMAT2 (zinc finger matrin-type 2)." FBgn0035518 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in embryonic/larval muscle system and organism. Orthologous to human NFXL1 (nuclear transcription factor, X-box binding like 1)." FBgn0041171 FlyBase Gene Snapshot "archipelago (ago) encodes a protein that is the founding member of the Ago/Fbxw7 family of tumor suppressor genes and the substrate adaptor component of the SCF-Ago ubiquitin ligase. The product of ago has various substrates including the bHLH transcription factors encoded by Myc, trh, and sima, and the G1 cell cycle kinase component encoded by CycE. The product of ago presents tissue specific roles in cell proliferation, survival, and hypoxia-induced gene expression." FBgn0001257 UniProtKB "Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. (UniProtKB:Q09024)" FBgn0035512 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0035511 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head and adult heart. FBgn0035510 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head and organism. FBgn0035508 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic hindgut; embryonic ventral epidermis; and hindgut proper primordium. FBgn0028664 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase, V0 domain. Is expressed in adult heart and organism. Orthologous to several human genes including ATP6V0E2 (ATPase H+ transporting V0 subunit e2)." FBgn0040697 FlyBase Gene Snapshot tipE homolog 3 (Teh3) encodes a protein involved in regulation of sodium transport. FBgn0035505 FlyBase Gene Snapshot tipE homolog 2 (Teh2) encodes a protein involved in regulation of sodium transport. FBgn0035504 Alliance Predicted to enable sodium channel regulator activity. Predicted to be involved in regulation of sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0011653 UniProtKB "In embryogenesis, has a role in somatic muscle attachment and in the development of axonal pathways probably by stabilizing cell-matrix adhesion and/or by acting as a competitive antagonist of serine proteases. (UniProtKB:Q9VZH2)" FBgn0004574 UniProtKB May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein. (UniProtKB:Q07327) FBgn0035499 FlyBase Gene Snapshot Chd64 (Chd64) encodes a protein involved in the juvenile hormone mediated signaling pathway. FBgn0004516 FlyBase Gene Snapshot "Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching." FBgn0016013 Alliance Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Is expressed in embryonic Malpighian tubule; embryonic dorsal epidermis; and embryonic pars intercerebralis. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase). FBgn0024179 FlyBase Gene Snapshot "wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells." FBgn0035491 FlyBase Gene Snapshot Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. FBgn0035488 Alliance Predicted to be active in cytoplasm. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in Cayman type cerebellar ataxia and cerebellar ataxia. Orthologous to several human genes including ATCAY (ATCAY kinesin light chain interacting caytaxin) and BNIP2 (BCL2 interacting protein 2). FBgn0052251 FlyBase Gene Snapshot Claspin (Claspin) encodes a nuclear protein that is involved in the ATR-Chk1 checkpoint pathway. It is required for the cell cycle checkpoint induced at midblastula transition. FBgn0052250 Alliance Predicted to enable nucleotide transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in peroxisomal membrane. Is expressed in adult head. Orthologous to human SLC25A17 (solute carrier family 25 member 17). FBgn0035534 Alliance "Predicted to enable small ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gastric caecum; and gut section. Orthologous to human MRPS6 (mitochondrial ribosomal protein S6)." FBgn0035539 FlyBase Gene Snapshot slowdown (slow) encodes a protein secreted from tendon cells and is required for integrin-mediated muscle-tendon adhesion. FBgn0035540 FlyBase Gene Snapshot "Syntaxin 17 (Syx17) encodes a Qa type SNARE protein localizing to ER, mitochondria and autophagosomes. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Snap29 and Vamp7. The product of Syx17 roles include autophagosome clearance and neuromuscular function." FBgn0035542 FlyBase Gene Snapshot Tumor protein p53 inducible nuclear protein (TP53INP) encodes a transcriptional coactivator of ecdysone receptor signaling required during metamorphosis. It is antagonized by insulin signaling via the product of foxo in the fat body and forms part of a feed-forward mechanism whereby ecdysone potentiates its own signaling. The product of TP53INP also regulates autophagosome formation and protein degradation via ecdysone signaling. FBgn0035543 Alliance Predicted to be a structural constituent of chitin-based cuticle. Predicted to be involved in cell morphogenesis. Predicted to be located in membrane. FBgn0000038 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor beta1 (nAChRbeta1) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel." FBgn0035552 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). FBgn0035557 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic proventriculus inner layer; embryonic ventral epidermis; and gut section." FBgn0035558 Alliance "Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in adult head and wing disc. Orthologous to human B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5)." FBgn0015805 UniProtKB "Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:11571273, PubMed:12408863, PubMed:28245922). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:11571273, PubMed:15306652, PubMed:15545624, PubMed:8955276). For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones (PubMed:11571273). Involved in position-effect variegation (PEV) (PubMed:11571273). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) (PubMed:28245922). (UniProtKB:Q94517)" FBgn0052243 Alliance Is expressed in germline cell; gonad; organism; and primordial germ cell. FBgn0014073 FlyBase Gene Snapshot Tie-like receptor tyrosine kinase (Tie) encodes a predicted transmembrane tyrosine kinase receptor. Its potential ligands for include Pvf protein family members. It may be involved in cell survival and cell migration. FBgn0035547 Alliance Is expressed in embryonic dorsal epidermis. FBgn0035541 Alliance "Predicted to enable basal RNA polymerase II transcription machinery binding activity. Predicted to be involved in dendrite extension. Predicted to be active in nucleolus. Orthologous to human LLPH (LLP homolog, long-term synaptic facilitation factor)." FBgn0035538 FlyBase Gene Snapshot "Dopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite." FBgn0035537 UniProtKB Probable RNA methyltransferase. (UniProtKB:Q9VZD2) FBgn0035533 FlyBase Gene Snapshot Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics. FBgn0035532 Alliance Predicted to enable RNA binding activity. Predicted to be involved in tRNA modification. Orthologous to human THUMPD1 (THUMP domain containing 1). FBgn0066365 FlyBase Gene Snapshot "dusky-like (dyl) encodes a plasma membrane protein involved in actin filament organization. It is involved in apical constriction, cell-matrix adhesion and hair morphogenesis." FBgn0052238 Alliance Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cilium. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). FBgn0035574 FlyBase Gene Snapshot Rho guanine nucleotide exchange factor at 64C (RhoGEF64C) encodes a guanine nucleotide exchange factor with apical protein localization. In some ectodermal cells localization is controlled at the level of RNA. FBgn0027085 Alliance "Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; anal pad primordium; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial)." FBgn0035581 FlyBase Gene Snapshot "dynein, axonemal, heavy chain 3 (Dnah3) encodes a motor protein involved in hearing and sperm competition." FBgn0035582 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Is expressed in embryonic dorsal epidermis and embryonic/larval posterior spiracle. FBgn0035583 Interactive Fly "smooth septate junction component - transmembrane protein forms a complex with Ssk, Mesh, and Tsp2A and is required for the correct localization of these proteins to septate junctions - knockdown in the adult midgut leads to intestinal barrier dysfunction and stem cell overproliferation - required for maintaining intestinal stem cell homeostasis through the regulation of aPKC and Yki activities" FBgn0028699 Alliance Enables ammonium channel activity. Involved in ammonium transmembrane transport; cellular response to ammonium ion; and detection of chemical stimulus involved in sensory perception of smell. Is active in plasma membrane. Is expressed in adult head. FBgn0052237 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Is expressed in embryonic brain and larval ventral nerve cord. FBgn0035578 Alliance Is expressed in antennal disc; eye disc; leg disc; and wing disc. FBgn0035577 Alliance Orthologous to human LRRC49 (leucine rich repeat containing 49). FBgn0042131 Alliance Predicted to enable oxidoreductase activity. Is expressed in adult head. FBgn0035575 Alliance Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CPN2 (carboxypeptidase N subunit 2); GP5 (glycoprotein V platelet); and LRRC15 (leucine rich repeat containing 15). FBgn0035571 Alliance Enables siRNA binding activity. Located in nucleus. Is expressed in adult head; clypeo-labral primordium; and gonad. FBgn0035568 Alliance "Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; phosphate ion transmembrane transport; and thiosulfate transport. Is expressed in adult head. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11)." FBgn0035567 Alliance "Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; phosphate ion transmembrane transport; and thiosulfate transport. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11)." FBgn0046793 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Is expressed in organism. FBgn0035585 Alliance "Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP metabolic process. Predicted to be part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in adult head and spermatozoon. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6)." FBgn0052232 Alliance Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in centriole and mitochondrial outer membrane. FBgn0035584 Alliance Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. FBgn0005775 FlyBase Gene Snapshot Connectin (Con) encodes a transmembrane homophilic cell adhesion protein involved in axon guidance and target recognition. FBgn0030234 Alliance "Predicted to be active in membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic/larval midgut primordium; and gut section." FBgn0040850 Alliance Is expressed in adult fat body. FBgn0030237 Alliance Is expressed in embryonic/larval garland cell and embryonic/larval pericardial cell. FBgn0030239 FlyBase Gene Snapshot "6-phosphogluconolactonase (Pgls) encodes an enzyme that catalyzes the hydrolysis of 6-phospho-D-glucono 1,5-lactone into 6-phospho-D-gluconate. It is involved in the oxidative branch of the pentose phosphate pathway." FBgn0030240 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human ZNF646 (zinc finger protein 646)." FBgn0030243 Alliance Predicted to enable RNA binding activity. Is expressed in organism; wing hinge primordium; and wing pouch. Orthologous to human RBM33 (RNA binding motif protein 33). FBgn0030244 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and embryonic large intestine." FBgn0030247 Alliance Predicted to be involved in cytoskeleton organization. Human ortholog(s) of this gene implicated in axial spondylometaphyseal dysplasia. Orthologous to human CFAP410 (cilia and flagella associated protein 410). FBgn0003965 UniProtKB Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety (PubMed:23333332). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway (PubMed:2108317). (UniProtKB:P20351) FBgn0030251 UniProtKB "Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end. (UniProtKB:Q9VZ49)" FBgn0030257 Alliance Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Located in cytoplasm and nucleus. FBgn0030261 Alliance "Predicted to be located in extracellular space. Is expressed in several structures, including adult heart; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval fat body; and exit glial cell." FBgn0030260 Alliance Is expressed in organism. FBgn0030259 Alliance Is expressed in adult head and organism. FBgn0030258 Alliance Predicted to be located in extracellular space. Is expressed in adult head. FBgn0021742 Alliance Predicted to enable Notch binding activity. Predicted to be involved in cell communication. Predicted to be located in membrane. FBgn0052670 FlyBase Gene Snapshot "Rab at 9Fb (Rab9Fb) encodes a protein of the Rab family of small monomeric Ras-like GTPases. Rab proteins are key regulators of endomembrane traffic. Rab9Fb localizes to endoplasmic reticulum (ER) exit sites, between ER and Golgi. Its loss of function impairs general ER-to-Golgi transport of secretory cargos." FBgn0052671 Alliance Predicted to enable GTPase activity. Predicted to be involved in Rab protein signal transduction; endocytic recycling; and secretion by cell. Predicted to be located in vesicle. Predicted to be active in cytoplasmic vesicle and plasma membrane. FBgn0030246 Alliance "Predicted to enable RNA binding activity and helicase activity. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human DHX57 (DExH-box helicase 57)." FBgn0017561 FlyBase Gene Snapshot "Open rectifier K[+] channel 1 (Ork1) encodes a member of the two pore open rectifier potassium channel gene family. It contributes to the regulation of membrane resting potential. The primary gating mechanism for the product of Ork1 appears to be based on phosphorylation of multiple serine, threonine and tyrosine residues in the large intracellular C-terminal tail." FBgn0030245 Alliance "Predicted to enable acid phosphatase activity and metal ion binding activity. Is expressed in several structures, including adult head; adult heart; anterior endoderm; circulatory system primordium; and mesoderm. Orthologous to human ACP7 (acid phosphatase 7, tartrate resistant (putative))." FBgn0030242 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle midzone assembly. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in wing hinge primordium and wing pouch. Orthologous to human PRC1 (protein regulator of cytokinesis 1). FBgn0030241 FlyBase Gene Snapshot fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. FBgn0003321 UniProtKB "Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm (PubMed:11779805, PubMed:11780633, PubMed:11780634, PubMed:27016737). In ovarian follicle cells, plays a role in transposable element silencing regulation by enabling the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346). (UniProtKB:Q9U1H9)" FBgn0052669 Alliance "Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to several human genes including SLC5A6 (solute carrier family 5 member 6)." FBgn0003360 UniProtKB "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). (UniProtKB:Q26365)" FBgn0025111 Alliance Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6). FBgn0030263 Alliance "Predicted to enable calcium channel activity and calcium:proton antiporter activity. Predicted to be involved in several processes, including calcium export from the mitochondrion; negative regulation of release of cytochrome c from mitochondria; and positive regulation of mitochondrial ATP synthesis coupled electron transport. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; adult heart; and organism. Orthologous to human GHITM (growth hormone inducible transmembrane protein)." FBgn0027498 Alliance Predicted to be involved in carbohydrate metabolic process and peptide modification. Predicted to be active in plasma membrane. Is expressed in organism. Orthologous to human LANCL3 (LanC like family member 3). FBgn0015245 UniProtKB Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (UniProtKB:O02649) FBgn0028686 Alliance "Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in male germ cell nucleus. Part of proteasome regulatory particle, base subcomplex. Is expressed in adult head and organism. Used to study neurodegenerative disease. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4)." FBgn0030269 Alliance "Predicted to enable DNA polymerase binding activity. Predicted to be involved in positive regulation of protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central brain primordium; embryonic hindgut; ganglia; and gonad. Orthologous to several human genes including CDK2AP1 (cyclin dependent kinase 2 associated protein 1)." FBgn0030271 Alliance Predicted to be located in extracellular space. Is expressed in embryonic/larval salivary gland. FBgn0030272 Alliance Predicted to be located in extracellular space. FBgn0030274 FlyBase Gene Snapshot l(3)mbt interacting protein 1 (Lint-1) encodes a nuclear protein that associates with the product of l(3)mbt in the LINT complex. It is involved in the repression of malignant brain tumor signature (MBTS) genes. FBgn0030276 FlyBase Gene Snapshot "Dynein light intermediate chain (Dlic) encodes a dynein subunit that contributes to microtubule-based movement. It is involved in axogenesis, dendrite morphogenesis, mRNA transport, oogenesis and mitosis." FBgn0030283 Alliance Is expressed in spermatozoon. FBgn0030286 UniProtKB "Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. (UniProtKB:Q9VZ08)" FBgn0030291 Alliance Is expressed in organism. Orthologous to human C1orf131 (chromosome 1 open reading frame 131). FBgn0030292 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head." FBgn0030293 Alliance Is expressed in adult head. FBgn0000499 UniProtKB "Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (UniProtKB:P51140)" FBgn0004864 FlyBase Gene Snapshot "hopscotch (hop) encodes a non-receptor tyrosine kinase for interleukin-like ligands (encoded by upd1, upd2, and upd3) and functions in the JAK-STAT signaling pathway. It is involved in embryonic segmentation, cell proliferation, and cell migration." FBgn0030289 Interactive Fly disrupts N-glycosylation of extracellular matrix proteins covering the fat body - invertebrate self-recognition system - N-glycans attached to extracellular matrix proteins serve as a self signal - activated hemocytes attack tissues lacking this signal FBgn0028421 FlyBase Gene Snapshot Kinesin associated protein 3 (Kap3) encodes the non-motor accessory subunit of the heterotrimeric kinesin-2. It associates to the coiled-coil stalk domain of the products of Klp68D andKlp64D. It plays an essential role in sensory cilia assembly and axonal transport. FBgn0001491 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human BUD31 (BUD31 homolog)." FBgn0003411 FlyBase Gene Snapshot sisterless A (sisA) encodes a transcription factor that activates transcription of the master feminizing switch gene Sxl specifically in diplo-X somatic cells. It is also required for proper embryonic midgut development in both sexes. FBgn0026268 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in cytoplasm. Is expressed in adult head and third segment of antenna. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0052668 Alliance Predicted to be involved in cilium organization. Human ortholog(s) of this gene implicated in spermatogenic failure 38. Orthologous to human ARMC2 (armadillo repeat containing 2). FBgn0020255 UniProtKB "GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis (By similarity). GTP-bound Ran modulates both spindle and nuclear envelope assembly, supporting a role during mitosis (PubMed:12121620). During oogenesis, modulates formation of Nup358-containing granules and biogenesis of the nuclear pore complex probably by mediating the transport of their components along microtubules (PubMed:31626769). (UniProtKB:Q9VZ23)" FBgn0030270 Alliance Predicted to be located in extracellular space. Is expressed in embryonic/larval salivary gland. FBgn0052667 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0030268 FlyBase Gene Snapshot "Kinesin-like protein at 10A (Klp10A) encodes a member of the kinesin superfamily of motor proteins (KIF) and of the kinesin-13 family of microtubule depolymerases. It induces microtubule depolymerization to regulate the length and dynamics of microtubules in a variety of cell processes and structures such as the mitotic and meiotic spindles, the centriole and interphase microtubules." FBgn0010391 UniProtKB "Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit Srp54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity). May have a role in axonogenesis (PubMed:8360279). (UniProtKB:Q9U5L1)" FBgn0030266 Alliance "Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; embryonic/larval nervous system; and ganglia." FBgn0027359 UniProtKB Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The Tim8-Tim13 complex mediates the import of some proteins while the predominant Tim9-Tim10 70 kDa complex mediates the import of much more proteins (By similarity). (UniProtKB:Q9Y1A3) FBgn0001145 FlyBase Gene Snapshot Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly. FBgn0030300 FlyBase Gene Snapshot "Sphingosine kinase 1 (Sk1) encodes an enzyme that catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. It regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair." FBgn0030301 FlyBase Gene Snapshot Heterochromatin protein 5 (HP5) encodes a component of classical heterochromatin that is involved in gene silencing by heterochromatin. FBgn0030304 UniProtKB Probably involved in steroid hormones biosynthesis. (UniProtKB:Q9VYY4) FBgn0030305 FlyBase Gene Snapshot "Ubiquitin-like activating enzyme 5 (Uba5) encodes a member of the E1-like ubiquitin-activating enzyme family. It activates the protein encoded by Ufm1, and acts as a key factor in the ufmylation process. It is involved in ATP binding, catalytic activity, cofactor binding, metal ion binding, nucleotide binding and oxidoreductase activity." FBgn0030306 UniProtKB Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). (UniProtKB:Q9VYY2) FBgn0052666 FlyBase Gene Snapshot Death-associated protein kinase related (Drak) encodes a protein serine/threonine kinase belonging to the Death-associated protein kinase family. It promotes phosphorylation of the product of sqh at sites known to stimulate actomyosin contractility. Its main characterized function is to shape epithelial tissues during development. FBgn0030310 FlyBase Gene Snapshot "Peptidoglycan recognition protein SA (PGRP-SA) encodes a secreted protein that mediates Toll pathway activation during bacterial infection. It binds to peptidoglycans and, together with the product of GNBP1, activates the serine protease encoded by modSP." FBgn0030311 Alliance Is expressed in organism. Orthologous to human TMEM242 (transmembrane protein 242). FBgn0030313 Alliance Involved in male germ-line cyst formation. FBgn0030314 Alliance "Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including antennal anlage; antennal primordium; anterior endoderm anlage; head epidermis primordium; and mesoderm. Orthologous to human ZNF212 (zinc finger protein 212) and ZNF671 (zinc finger protein 671)." FBgn0030316 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. FBgn0019660 Interactive Fly non-coding RNA - dosage compensation - activation of male specific lethal proteins - Upstream of N-Ras is a conserved RNA-binding protein that promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2. FBgn0002948 FlyBase Gene Snapshot no distributive disjunction (nod) encodes a kinesin-like protein that is important for nonexchange chromosome biology. The nod product is necessary for chromosome segregation during meiosis and for proper chromosome alignment along the meiotic spindle. FBgn0030318 FlyBase Gene Snapshot "rhomboid-4 (rho-4) encodes a member of the rhomboid superfamily of intramembrane serine proteases, which cleave to release proteins from the membrane. It processes the transmembrane EGF ligands encoded by spi, Krn, and grk. Its activity is directly and dramatically stimulated by calcium." FBgn0030321 Alliance Predicted to enable ATP binding activity. Is expressed in adult head. Orthologous to human ABCF1 (ATP binding cassette subfamily F member 1). FBgn0002723 FlyBase Gene Snapshot Methoprene-tolerant (Met) encodes bHLH-PAS domain transcription factor paralogous to gce. It is a receptor for the sesquiterpenoid juvenile hormone. FBgn0004370 FlyBase Gene Snapshot "Protein tyrosine phosphatase 10D (Ptp10D) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp4E. Ptp4E-Ptp10D double mutants have lethal respiratory defects. Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp10D regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. It also binds to the product of sas to regulate its signaling in glia." FBgn0014133 FlyBase Gene Snapshot bifocal (bif) encodes an actin and microtubule binding protein involved in axon guidance and regulation of axon extension. FBgn0030326 Alliance Predicted to be located in extracellular space. FBgn0030323 FlyBase Gene Snapshot Valette (Vlet) encodes a protein that is required in muscle for adult viability and neuromuscular function. FBgn0030320 Alliance Involved in defense response to bacterium. Located in nucleus. Is expressed in organism. FBgn0030317 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head; eye; mesoderm anlage; organism; and ventral ectoderm anlage. FBgn0000618 FlyBase Gene Snapshot "enhancer of yellow 2 (e(y)2) encodes a subunit of TREX2 mRNA nuclear export complex. It is also a subunit of histone deubiquitination module of SAGA complex. The product of e(y)2 is essential for general nuclear export of mRNA, transcription activation and gene positioning in the nuclei." FBgn0027259 FlyBase Gene Snapshot kinetochore Mis12-Ndc80 network component 1 (Kmn1) encodes a protein involved in the movement of chromosomes during mitosis. FBgn0003277 UniProtKB "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). (UniProtKB:P04052)" FBgn0030309 Alliance "Involved in positive regulation of hemocyte proliferation. Predicted to be active in membrane. Is expressed in several structures, including Bolwig organ; adult head; embryonic head epidermis; embryonic proventriculus; and embryonic/larval circulatory system." FBgn0030298 FlyBase Gene Snapshot Odorant receptor 10a (Or10a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0045502 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58950)" FBgn0030297 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9VYZ2)" FBgn0030329 FlyBase Gene Snapshot pretaporter (prtp) encodes a ligand for the engulfment receptor encoded by drpr. It resides in the endoplasmic reticulum. During apoptosis it is exposed at the cell surface where it binds the product of drpr to induce phagocytosis. FBgn0030330 Alliance Involved in protein secretion. Located in cytosol. Is expressed in spermatozoon. Orthologous to human BTBD17 (BTB domain containing 17). FBgn0030331 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human SVOPL (SVOP like). FBgn0002577 FlyBase Gene Snapshot miniature (m) encodes a protein that belongs to the ZP-domain proteins family known as extracellular modular proteins. These proteins are secreted and anchored to the membrane or released into the extracellular space to form specialized extracellular matrices. FBgn0030334 Alliance Predicted to be involved in lipid metabolic process and response to reactive oxygen species. Predicted to be active in cytoplasm. FBgn0030339 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VYT8) FBgn0030343 FlyBase Gene Snapshot "ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development." FBgn0030345 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in protein maturation by protein folding and protein targeting to mitochondrion. Predicted to be located in cytosol. Is expressed in embryonic/larval crystal cell; organism; and procrystal cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; pituitary adenoma 1; and retinitis pigmentosa. Orthologous to several human genes including AIP (aryl hydrocarbon receptor interacting protein). FBgn0030347 Alliance "Enables phosphatase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval crystal cell; embryonic/larval fat body; embryonic/larval midgut; and procrystal cell." FBgn0030350 FlyBase Gene Snapshot "Selenoprotein G (SelG) encodes a type III Golgi apparatus transmembrane protein. It is implicated in the release of Ca[2+] from the endoplasmic reticulum to the cytosol by regulating the expression of genes participating in the inositol 1,4,5-tris-phosphate pathway." FBgn0030351 Alliance Predicted to be involved in calcium ion transport and endoplasmic reticulum calcium ion homeostasis. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. FBgn0030352 UniProtKB Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (Complex I) at early stages (PubMed:23509070). Interacts with cytosolic Hsp90 to chaperone the Complex I subunit ND-42 in the cytoplasm (PubMed:23509070). (UniProtKB:Q9VYS5) FBgn0030360 Alliance "Predicted to be located in plasma membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Predicted to be active in sarcolemma. Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; embryonic hypopharynx; and gut section. Orthologous to human SSPN (sarcospan)." FBgn0030362 Alliance "Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; amnioserosa; dorsal pharyngeal muscle primordium; and embryonic/larval somatic muscle cell. Orthologous to human RGN (regucalcin)." FBgn0030361 Alliance "Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to human GGT1 (gamma-glutamyltransferase 1); GGT2P (gamma-glutamyltransferase 2, pseudogene); and GGT5 (gamma-glutamyltransferase 5)." FBgn0001083 FlyBase Gene Snapshot furrowed (fw) encodes a selectin that mediates the interaction of planar cell polarity proteins by stabilizing the product of fz. FBgn0030359 Alliance Is expressed in spermatozoon. Orthologous to human NME9 (NME/NM23 family member 9). FBgn0003865 FlyBase Gene Snapshot "twisted gastrulation (tsg) encodes a BMP binding protein that makes a tripartite complex with the product of sog and a heterodimer formed with the products of dpp and scw. This complex is a favoured substrate for the product of tld, which processes the product of sog and liberates the heterodimer formed with the products of dpp and scw." FBgn0000808 FlyBase Gene Snapshot gastrulation-defective (gd) encodes a secreted serine protease. It is a member of the protease cascade that generates the ligand that activates the receptor encoded by Tl. It contributes to establishment of the dorsal-ventral embryonic axis. FBgn0030358 Alliance Predicted to enable lipid binding activity. Involved in mitochondrion-endoplasmic reticulum membrane tethering. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in adult head. Used to study syndromic intellectual disability. Orthologous to human PDZD8 (PDZ domain containing 8). FBgn0030357 Alliance Involved in muscle system process. Is expressed in embryonic/larval somatic muscle cell. Orthologous to human LRRC20 (leucine rich repeat containing 20). FBgn0030354 UniProtKB RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity). (UniProtKB:Q9VYS3) FBgn0030349 Alliance Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in extracellular exosome. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). FBgn0030348 Alliance Predicted to enable phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in organism. FBgn0030346 Alliance Predicted to be involved in lysosome localization; organelle transport along microtubule; and positive regulation of anterograde synaptic vesicle transport. Predicted to be part of BORC complex. Predicted to be active in cytoplasmic side of lysosomal membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5). FBgn0030344 FlyBase Gene Snapshot Nardilysin (Nrd1) encodes a protein involved in chaperone-mediated protein folding. FBgn0030342 Alliance Predicted to be located in nucleoplasm. Orthologous to human NUDCD1 (NudC domain containing 1). FBgn0030341 FlyBase Gene Snapshot p24-related-1 (p24-1) encodes a p24 protein that contributes to the secretion of Wnt ligands. FBgn0030340 Alliance Predicted to be active in Golgi apparatus. FBgn0001218 UniProtKB Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). (UniProtKB:P29844) FBgn0004511 FlyBase Gene Snapshot "dusky (dy) encodes a membrane-anchored protein of the zona pellucida domain protein familiy. Along with the homologous gene m, it regulates epidermal cell size/shape changes during wing morphogenesis. It also functions to remodel epidermal cell shape during embryonic and later developmental stages, through interactions with the extracellular matrix." FBgn0030332 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult head; embryonic midgut chamber; and embryonic/larval midgut. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0030328 Alliance Involved in chaeta development; compound eye development; and wing disc development. Located in nucleus. FBgn0030327 UniProtKB "Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated. (UniProtKB:Q9VYV5)" FBgn0030364 UniProtKB "Component of the Atx2-tyf activator complex which functions in the circadian pacemaker neurons to activate the TYF-dependent translation of per and maintain 24 hour periodicity in circadian behaviors. Within the Atx2-tyf complex, likely to function as a molecular adapter which stabilizes the interaction between Atx2 and the translational regulator tyf. (UniProtKB:Q9VYR0)" FBgn0030365 Alliance Involved in Golgi organization and protein secretion. Located in cytosol. Part of Prp19 complex. Is expressed in adult head and organism. Orthologous to human PLRG1 (pleiotropic regulator 1). FBgn0030369 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VYQ5) FBgn0030377 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human CLGN (calmegin) and CANX (calnexin). FBgn0030375 Alliance Predicted to enable GTP binding activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm and microtubule cytoskeleton. FBgn0030373 UniProtKB "Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers. Moonshiner/CG12721 recruits transcriptional machinery to heterochromatin to initiate the bidirectional transcription of piRNA clusters. Functions by forming a complex with transcription initiation factors TfIIA-S and Trf2, and interacting with del which is part of the RDC (rhi, del and cuff) complex that binds to repressive H3K9me3 marks in the chromatin. This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark. (UniProtKB:Q9VYQ0)" FBgn0030370 Alliance Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle. Predicted to be active in cytoplasm. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). FBgn0030367 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VYQ7) FBgn0030366 UniProtKB Hydrolase that deubiquitinates target proteins. (UniProtKB:Q9VYQ8) FBgn0043001 FlyBase Gene Snapshot "Chromatin accessibility complex 16kD protein (Chrac-16) encodes a subunit of the chromatin accessibility complex, which is an evolutionary conserved nucleosome sliding enzyme." FBgn0030384 Alliance "Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1)." FBgn0030386 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. FBgn0030394 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; and prothoracic gland. FBgn0002562 UniProtKB Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (UniProtKB:P11995) FBgn0030396 Alliance "Predicted to enable actin binding activity. Located in brush border. Is expressed in several structures, including Malpighian tubule primordium; embryonic ventral epidermis; embryonic/larval fat body; embryonic/larval salivary gland; and salivary gland body primordium." FBgn0030398 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic ventral epidermis and larval foregut atrium. FBgn0052654 FlyBase Gene Snapshot "Secretory 16 (Sec16) encodes a protein involved in the organization of endoplasmic reticulum exit sites. It contributes to stress response to amino-acid starvation, during which it mediates the formation of both Sec bodies and stress granules." FBgn0030407 Alliance Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to be active in cytosol and mitochondrion. Orthologous to human FPGS (folylpolyglutamate synthase). FBgn0030408 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0030406 Alliance "Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; and visceral muscle primordium. Orthologous to human ZNHIT6 (zinc finger HIT-type containing 6)." FBgn0030403 Alliance Predicted to enable ATP binding activity and ATPase-coupled transmembrane transporter activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be part of mitochondrial ATP-gated potassium channel complex. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). FBgn0030400 Alliance "Enables ubiquitin protein ligase activity. Involved in regulation of gene expression. Located in cytoplasm and nuclear periphery. Colocalizes with polytene chromosome. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; presumptive embryonic/larval central nervous system; and synaptic neuropil domain. Used to study central nervous system disease and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14 and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Orthologous to several human genes including IRF2BP1 (interferon regulatory factor 2 binding protein 1) and IRF2BPL (interferon regulatory factor 2 binding protein like)." FBgn0030395 UniProtKB "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273). Required for ciliary structure and function (PubMed:27577095). (UniProtKB:Q9VYM3)" FBgn0030391 Alliance "Enables GTPase activity. Involved in Golgi organization. Acts upstream of with a positive effect on lipophagy. Located in cytosol. Colocalizes with Golgi apparatus and lipid droplet. Is expressed in larval ventral nerve cord. Orthologous to several human genes including RAB40C (RAB40C, member RAS oncogene family)." FBgn0030390 Alliance "Is expressed in several structures, including anterior endoderm anlage; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and mesoderm." FBgn0030385 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in sensory perception of taste. Predicted to be located in membrane. Is expressed in adult abdomen; compound sense organ; gustatory receptor neurons; and labellar taste bristle. FBgn0030411 Alliance Predicted to enable glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in cytoplasm. Orthologous to human CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). FBgn0030412 FlyBase Gene Snapshot Tomosyn (Tomosyn) encodes a protein involved in long-term memory and neuromuscular synaptic transmission. FBgn0015024 FlyBase Gene Snapshot "Casein kinase Ialpha (CkIalpha) encodes a member of the CK1 family of Ser/Thr kinases with a preference for acidic substrates. It is involved in multiple signaling pathways, including Wingless and Hedgehog, that control cell growth and patterning." FBgn0030417 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human BACH1 (BTB domain and CNC homolog 1)." FBgn0030418 Alliance Located in nucleus. FBgn0030421 Alliance Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to several human genes including AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). FBgn0030425 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0030433 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Orthologous to human MRPL49 (mitochondrial ribosomal protein L49). FBgn0030435 Alliance Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in adult head. Orthologous to human YIPF1 (Yip1 domain family member 1) and YIPF2 (Yip1 domain family member 2). FBgn0030434 FlyBase Gene Snapshot BRMS1 (Brms1) encodes a protein involved in regulation of the ecdysone signaling and the Notch signaling pathway in the wing. FBgn0030432 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in germarium; organism; and primordial germ cell. FBgn0030431 Alliance Predicted to enable FMN adenylyltransferase activity. Predicted to be involved in FAD biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). FBgn0052649 Alliance "Predicted to enable ATP hydrolysis activity; lipid binding activity; and protein kinase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut primordium; foregut primordium; and gut section. Used to study coenzyme Q10 deficiency disease; nephrotic syndrome; nephrotic syndrome type 9; and primary coenzyme Q10 deficiency 4. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B)." FBgn0030429 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. FBgn0052647 Alliance Predicted to be active in membrane. Orthologous to human DGCR2 (DiGeorge syndrome critical region gene 2). FBgn0030420 FlyBase Gene Snapshot "pirate (pira) encodes a SUMO protease involved in dendrite targeting and is a target of Y-linked petrel piRNAs in testis. pira expression is normally repressed during spermatocyte differentiation, but gets strongly derepressed in either piRNA pathway mutants or XO males that do not have a Y chromosome." FBgn0020513 FlyBase Gene Snapshot "PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes." FBgn0030410 Alliance "Involved in negative regulation of G2/M transition of mitotic cell cycle. Located in cytosol and nucleus. Is expressed in several structures, including embryonic/larval salivary gland; embryonic/larval tracheal system; epithelium; germ layer; and larval ventral nerve cord." FBgn0052642 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. FBgn0052644 Alliance Predicted to be an extracellular matrix structural constituent. Involved in chorion-containing eggshell formation. Predicted to be located in extracellular matrix. Is expressed in organism. FBgn0030438 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. FBgn0052643 Alliance Is expressed in adult head. FBgn0030447 UniProtKB Hydrolyzes dipeptides containing N-terminal aspartate residues. (UniProtKB:Q9VYH3) FBgn0030451 Alliance "Predicted to enable oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm." FBgn0030452 Alliance Predicted to enable transmembrane transporter activity. Involved in negative regulation of cell population proliferation and phosphate ion transport. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0052645 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0030456 Alliance Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in carcinoma (multiple) and lung disease (multiple). Orthologous to human CLPTM1L (CLPTM1 like). FBgn0030457 UniProtKB Acts as a chaperone during the assembly of the 26S proteasome. (UniProtKB:Q9VYG1) FBgn0052640 Alliance Is expressed in adult head. FBgn0052641 Alliance Is expressed in adult head. FBgn0029133 FlyBase Gene Snapshot REG (REG) encodes an endopeptidase regulator involved in the regulation of the mitotic G1/S transition and proteasomal protein catabolism. FBgn0004456 FlyBase Gene Snapshot "multiple edematous wings (mew) encodes one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for the extracellular matrix protein laminin. It is required in numerous tissues for cell migration, adhesion between cell layers, and cell differentiation." FBgn0030460 UniProtKB "Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). (UniProtKB:Q9VYF8)" FBgn0030459 Alliance "Is expressed in several structures, including adult head and embryonic/larval tracheal section." FBgn0025463 FlyBase Gene Snapshot Brahma associated protein 60kD (Bap60) encodes a protein required for Brahma complex function. It represses neuroblast proliferation and regulates heterochromatin assembly. FBgn0030455 Alliance Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in germline cell. FBgn0052638 Alliance Predicted to be involved in angiotensin-activated signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Orthologous to human AGTRAP (angiotensin II receptor associated protein). FBgn0030449 FlyBase Gene Snapshot Ferritin 3 heavy chain homologue (Fer3HCH) encodes a iron storage protein involved in iron homeostasis. FBgn0010303 FlyBase Gene Snapshot hemipterous (hep) encodes a serine/threonine protein kinase involved in the Jun-N-terminal kinase pathway by phosphorylating the product of bsk. FBgn0030443 Alliance Predicted to enable UDP-galactosyltransferase activity. Predicted to be involved in N-glycan processing and glycosylation. Predicted to be active in cytoplasm. FBgn0030440 Alliance "Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be active in membrane." FBgn0030439 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. Predicted to be active in extracellular region. FBgn0030437 FlyBase Gene Snapshot hector (hec) encodes a G-protein coupled receptor involved in male courtship behavior. FBgn0000346 FlyBase Gene Snapshot comatose (comt) encodes the N-ethylmaleimide-Sensitive Factor 1 protein. It is required for maintenance of neurotransmitter release through disassembly or rearrangement of plasma membrane SNARE complexes following synaptic vesicle fusion. FBgn0030465 Alliance "Predicted to enable 3'-nucleotidase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Located in endomembrane system. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)." FBgn0030466 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including ADGRA2 (adhesion G protein-coupled receptor A2). FBgn0030468 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in several structures, including antennal anlage; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human PRPF38B (pre-mRNA processing factor 38B)." FBgn0040309 UniProtKB "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). (UniProtKB:Q9V3P0)" FBgn0030474 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human NSRP1 (nuclear speckle splicing regulatory protein 1)." FBgn0030477 FlyBase Gene Snapshot doublesex-Mab related 11E (dmrt11E) encodes a transcription factor-like protein containing a highly conserved DNA-binding DM domain that plays a critical role in sex determination and spermatogenesis. FBgn0030478 Alliance "Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Involved in pyruvate metabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including adult brain; adult neuromere; ganglia; germline cell; and synaptic neuropil domain. Orthologous to human GPT (glutamic--pyruvic transaminase) and GPT2 (glutamic--pyruvic transaminase 2)." FBgn0030480 FlyBase Gene Snapshot Tim9a (Tim9a) encodes a subunit of the soluble mitochondrial intermembrane space protein transporter complex that acts as a chaperone for the import and insertion of proteins into the mitochondrial inner membrane. FBgn0030481 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in mitochondrial ribosome assembly and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). FBgn0030482 Alliance Enables L-isoleucine transaminase activity; L-leucine transaminase activity; and L-valine transaminase activity. Involved in L-leucine catabolic process; isoleucine catabolic process; and valine catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Orthologous to several human genes including BCAT2 (branched chain amino acid transaminase 2). FBgn0030484 Alliance "Predicted to enable glutathione peroxidase activity. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B)." FBgn0030486 FlyBase Gene Snapshot SET domain containing 2 (Set2) encodes an essential histone methyltransferase that marks active gene bodies with H3K36me3. FBgn0030492 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. FBgn0030493 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. FBgn0030494 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic head sensory system. FBgn0030485 Alliance Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). FBgn0030483 Alliance Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. FBgn0030479 FlyBase Gene Snapshot Rbp1-like (Rbp1-like) encodes a mRNA binding protein involved in RNA splicing and RNA metabolism. FBgn0010198 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Used to study intrinsic cardiomyopathy. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a). FBgn0030467 Alliance "Predicted to enable amino acid binding activity and dimethylargininase activity. Predicted to be involved in arginine metabolic process; citrulline metabolic process; and positive regulation of nitric oxide biosynthetic process. Is expressed in embryonic Malpighian tubule; embryonic dorsal epidermis; embryonic hindgut; embryonic main segment of Malpighian tubule; and embryonic ventral epidermis. Human ortholog(s) of this gene implicated in cardiovascular system disease; coronary artery disease; and hypertension. Orthologous to human DDAH2 (DDAH family member 2, ADMA-independent) and DDAH1 (dimethylarginine dimethylaminohydrolase 1)." FBgn0052633 Alliance Is expressed in adult head. FBgn0030499 Alliance Predicted to be involved in cell migration. Predicted to be located in recycling endosome. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human AVL9 (AVL9 cell migration associated). FBgn0030501 FlyBase Gene Snapshot BthD selenoprotein (BthD) encodes a protein involved in salivary gland development and lifespan determination. FBgn0030503 UniProtKB May play a role in Golgi organization. (UniProtKB:Q9VYA8) FBgn0030505 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of synaptic vesicle exocytosis and response to salt stress. Predicted to be part of transcription regulator complex. Is expressed in several structures, including adult mushroom body dorsal accessory calyx; anal pad primordium; calyx of adult mushroom body; embryonic anal pad; and embryonic hindgut. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1); NFATC3 (nuclear factor of activated T cells 3); and NFAT5 (nuclear factor of activated T cells 5)." FBgn0030507 Alliance "Predicted to be involved in RNA catabolic process. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including antennal anlage; ganglia; head epidermis primordium; mesoderm; and somatic precursor cell. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B)." FBgn0030508 Alliance Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in organelle membrane. FBgn0030509 Alliance Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). FBgn0030511 Alliance Predicted to enable ribosylpyrimidine nucleosidase activity. Predicted to be involved in pyrimidine nucleoside catabolic process. Is expressed in embryonic/larval muscle system; embryonic/larval somatic muscle cell; somatic muscle primordium; and visceral muscle primordium. FBgn0002878 FlyBase Gene Snapshot mutagen-sensitive 101 (mus101) encodes a protein involved in the DNA replication checkpoint during mitosis. FBgn0030518 UniProtKB "Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (UniProtKB:Q9VY93)" FBgn0030519 Alliance "Predicted to be located in peroxisome. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; ganglia; gut section; and visceral mesoderm derivative. Orthologous to human SCP2D1 (SCP2 sterol binding domain containing 1)." FBgn0020909 UniProtKB "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Does not have cyclase activity (By similarity). (UniProtKB:P56175)" FBgn0030528 Alliance Predicted to enable coenzyme A diphosphatase activity. Is expressed in adult head. Orthologous to human NUDT8 (nudix hydrolase 8). FBgn0027537 FlyBase Gene Snapshot "Nucleoporin 93kD-1 (Nup93-1) encodes a protein that directly interacts with the product of Nup154. However, the product of Nup93-1 is not necessary for the Nup154-dependent organization of the inner nuclear membrane proteins at the nuclear envelope." FBgn0052626 Alliance "Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; epithelium; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD2 (adenosine monophosphate deaminase 2)." FBgn0030530 FlyBase Gene Snapshot Ajuba LIM protein (jub) encodes a LIM domain-containing protein that binds to and inhibits activation of the Hippo pathway kinase encoded by wts. It localizes to adherens junctions in a tension-dependent manner. FBgn0030529 FlyBase Gene Snapshot Chloride intracellular channel (Clic) encodes a protein involved in chloride transport and alcohol-related behavior. FBgn0030525 Alliance Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to be located in cytosol. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase). FBgn0030524 Alliance Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human ABT1 (activator of basal transcription 1). FBgn0030521 FlyBase Gene Snapshot Cathepsin B1 (CtsB1) encodes a papain-like cysteine proteinase involved in lysosomal protein degradation. FBgn0030520 Alliance "Involved in germarium-derived female germ-line cyst formation and positive regulation of stem cell differentiation. Located in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and synaptic neuropil domain. Orthologous to human PDCD4 (programmed cell death 4)." FBgn0001612 FlyBase Gene Snapshot Gamma-tubulin ring protein 91 (Grip91) encodes a gamma-tubulin binding protein involved in male meiotic division and the organization of the meiotic spindle. FBgn0001087 FlyBase Gene Snapshot "garnet (g) encodes a protein that forms the Adaptor protein 3 (AP-3) complex together with the other subunits encoded by or, rb and cm. These complexes select cargo for inclusion into vesicles for transport within the cell. AP-3 delivers protein cargo to a number of specialized organelles including pigment granules, late endosomes, lysosomes and synaptic vesicles. AP-3 genes were first found through defects in pigment granules that alter eye color." FBgn0030514 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human MGRN1 (mahogunin ring finger 1) and RNF157 (ring finger protein 157). FBgn0030512 UniProtKB "Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged-related cardiac function, mobility, and lifespan (PubMed:27448710). (UniProtKB:Q9VYA0)" FBgn0030510 Alliance "Predicted to enable ribosylpyrimidine nucleosidase activity. Predicted to be involved in pyrimidine nucleoside catabolic process. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; ganglia; gut section; and mesoderm." FBgn0030506 FlyBase Gene Snapshot DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. FBgn0030504 Alliance Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in spermatozoon. Orthologous to human RRP12 (ribosomal RNA processing 12 homolog). FBgn0030502 Alliance Is expressed in organism. FBgn0030500 FlyBase Gene Snapshot Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression. FBgn0000173 FlyBase Gene Snapshot "bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response." FBgn0044817 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q9NIV2)" FBgn0011952 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011975 Alliance Predicted to enable UCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011976 Alliance Predicted to enable UCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011948 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011949 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011950 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011951 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011974 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011981 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0040871 Alliance Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). FBgn0011983 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011953 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011977 Alliance Predicted to enable UCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011982 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011980 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0030539 Alliance "Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adult head; embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral apodeme." FBgn0030541 Alliance Predicted to enable microtubule binding activity and transcription coactivator activity. Predicted to be involved in dendrite morphogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in microtubule. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adult head and embryonic ventral epidermis. FBgn0052603 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). FBgn0030543 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. FBgn0004649 UniProtKB "Cell surface receptor involved in uptake of vitellogenins (yolk proteins) into developing oocytes by receptor-mediated endocytosis (PubMed:10679010, PubMed:2886508, PubMed:7878005). May also mediate uptake of apolpp/apolipophorins and their incorporation into yolk granules (PubMed:33891588). Along with its ligands, required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis of vitellogenin receptor ligands is critical for osk (isoform A) mediated actin reorganization and the anchoring of germ plasm components to the oocyte cortex (PubMed:33891588). (UniProtKB:P98163)" FBgn0052600 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in adult head. FBgn0052601 Alliance Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. FBgn0030566 Alliance Part of nascent polypeptide-associated complex. Is expressed in adult head. FBgn0030569 Alliance "Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; and gut section." FBgn0052598 Alliance Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. FBgn0030563 Alliance Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. FBgn0030571 Alliance "Predicted to enable mRNA binding activity. Is expressed in several structures, including anterior endoderm; inclusive hindgut primordium; mesoderm; and posterior endoderm. Orthologous to human RBM18 (RNA binding motif protein 18)." FBgn0030573 Alliance Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in cilium movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and nucleoside triphosphate biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cilium. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). FBgn0030575 Alliance Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). FBgn0030577 Alliance Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. FBgn0030578 Alliance Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1) and MKRN2 (makorin ring finger protein 2). FBgn0015010 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0020508 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryonic midgut constriction 3 and embryonic/larval posterior midgut. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0030576 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). FBgn0015774 UniProtKB "Netrins control guidance of CNS commissural axons and peripheral motor axons (PubMed:11719202, PubMed:8780645, PubMed:8780646). Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively (PubMed:11719202). While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5 (PubMed:11719202). (UniProtKB:Q24568)" FBgn0030574 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Located in cell cortex. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC7A9 (solute carrier family 7 member 9). FBgn0030572 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 50. Orthologous to human MRPS25 (mitochondrial ribosomal protein S25). FBgn0030582 Alliance Involved in defense response to Gram-negative bacterium. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including MTMR10 (myotubularin related protein 10) and MTMR12 (myotubularin related protein 12). FBgn0000535 UniProtKB Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve. (UniProtKB:Q02280) FBgn0052594 FlyBase Gene Snapshot ben (be) encodes a protein involved in neuromuscular synaptic transmission and long-term memory formation. FBgn0030603 Alliance "Involved in long-term memory and neuromuscular synaptic transmission. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic large intestine; gonad; and gut section." FBgn0030605 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7). FBgn0030607 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10; coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including PNPLA2 (patatin like phospholipase domain containing 2); PNPLA3 (patatin like phospholipase domain containing 3); and PNPLA5 (patatin like phospholipase domain containing 5). FBgn0053177 Alliance Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Predicted to be located in membrane. Orthologous to several human genes including MGST1 (microsomal glutathione S-transferase 1). FBgn0053178 Alliance Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in mitochondrion. Is expressed in adult head; embryonic head sensory system; and labral sensory complex. Orthologous to several human genes including MGST1 (microsomal glutathione S-transferase 1). FBgn0030612 Alliance Predicted to enable acetyltransferase activity and lipoic acid binding activity. Predicted to contribute to branched-chain alpha-keto acid dehydrogenase activity. Involved in L-leucine catabolic process; isoleucine catabolic process; and valine catabolic process. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Used to study maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2). FBgn0030611 Alliance Predicted to be active in nucleus. Orthologous to human TMA16 (translation machinery associated 16 homolog). FBgn0030610 Alliance Predicted to enable copper chaperone activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be active in mitochondrial intermembrane space. Orthologous to human COX17 (cytochrome c oxidase copper chaperone COX17). FBgn0030608 FlyBase Gene Snapshot Lipid storage droplet-2 (Lsd-2) encodes a protein associated with lipid droplets. It acts as a barrier for lipases (such as the product of bmm) and thus prevents the mobilization of lipid stores. It is involved in regulation of lipid storage amount and energy homeostasis and acts in concert with the product of Lsd-1. FBgn0030600 UniProtKB "Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ) together with Rae1 and Fsn (PubMed:10839352, PubMed:17697379, PubMed:21874015). (UniProtKB:Q9NB71)" FBgn0027601 FlyBase Gene Snapshot pudgy (pdgy) encodes an acyl-CoA synthetase that activates fatty acids by conjugating them to CoA. It is a FOXO transcriptional target that preferentially activates fatty acids destined for beta-oxidation. FBgn0052591 Alliance Predicted to be active in cytoplasmic microtubule. Is expressed in adult head. FBgn0030598 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Is expressed in embryonic/larval tracheal dorsal trunk and embryonic/larval tracheal section. Orthologous to human CHDH (choline dehydrogenase). FBgn0030597 FlyBase Gene Snapshot Ecdysone oxidase (Eo) encodes an enzyme involved in ecdysone metabolism. FBgn0030596 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Located in egg chorion. Orthologous to human CHDH (choline dehydrogenase). FBgn0030594 FlyBase Gene Snapshot fezzik (fiz) encodes an ecdysone oxidase acting on both ecdysone and 20-dehydroecdysone. It appears to inhibit larval growth and may play a role in regulation of growth in response to nutrient availability. FBgn0030593 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Is expressed in adult head and adult heart. FBgn0030592 Alliance "Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; antennal primordium; and head epidermis primordium. Orthologous to human CHDH (choline dehydrogenase)." FBgn0030590 Alliance Predicted to enable oxidoreductase activity. Involved in response to endoplasmic reticulum stress. Is expressed in embryonic dorsal epidermis; embryonic proventriculus inner layer; embryonic ventral epidermis; and gut section. Orthologous to human CHDH (choline dehydrogenase). FBgn0030589 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Is expressed in ejaculatory bulb; male accessory gland; and organism. Orthologous to human CHDH (choline dehydrogenase). FBgn0030588 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Orthologous to human CHDH (choline dehydrogenase). FBgn0030587 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Is expressed in embryonic dorsal epidermis. Orthologous to human CHDH (choline dehydrogenase). FBgn0030586 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Orthologous to human CHDH (choline dehydrogenase). FBgn0052590 UniProtKB May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor. (UniProtKB:Q8IR45) FBgn0030584 Alliance "Predicted to enable disulfide oxidoreductase activity. Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5)." FBgn0003301 FlyBase Gene Snapshot "Adenylate cyclase 1 (Adcy1) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity." FBgn0030613 FlyBase Gene Snapshot "Rab3 GDP-GTP exchange factor (Rab3-GEF) encodes a guanine nucleotide exchange factor (GEF) for the small GTPase encoded by Rab3. They control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction." FBgn0030620 Alliance Predicted to be involved in mitochondrial outer membrane translocase complex assembly. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human MTX2 (metaxin 2). FBgn0030625 Alliance "Predicted to be involved in negative regulation of RNA catabolic process and regulatory ncRNA-mediated heterochromatin formation. Part of catalytic step 2 spliceosome. Orthologous to human NRDE2 (NRDE-2, necessary for RNA interference, domain containing)." FBgn0015926 FlyBase Gene Snapshot discontinuous actin hexagon (dah) encodes a protein required for cortical furrows during early embryogenesis that is recruited to the membrane in a process dependent on the product of nuf. FBgn0026428 FlyBase Gene Snapshot Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins. FBgn0030631 Alliance "Predicted to enable RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human DDX46 (DEAD-box helicase 46)." FBgn0030634 Alliance Orthologous to several human genes including WSCD2 (WSC domain containing 2). FBgn0003132 FlyBase Gene Snapshot Protein phosphatase 1 at 13C (Pp1-13C) encodes a phosphatase involved in hedgehog signaling regulation and sperm competition. FBgn0030630 Alliance "Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human PAK1IP1 (PAK1 interacting protein 1)." FBgn0030629 Alliance "Predicted to be involved in cell population proliferation and ribosome biogenesis. Predicted to be located in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human PAK1IP1 (PAK1 interacting protein 1)." FBgn0030628 Alliance Is expressed in organism. FBgn0030624 Alliance Is expressed in organism. FBgn0030623 Alliance Enables RNA binding activity. Involved in sexual reproduction. Located in cytoplasm. FBgn0030622 Alliance Is expressed in adult head. FBgn0030617 Alliance "Predicted to enable carbohydrate binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); atypical hemolytic-uremic syndrome; autoimmune disease (multiple); and hemolytic-uremic syndrome. Orthologous to human CD46 (CD46 molecule); APOH (apolipoprotein H); and SELL (selectin L)." FBgn0030616 UniProtKB Binds to the 23S rRNA. (UniProtKB:Q9VXX8) FBgn0030615 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VXY0) FBgn0030614 Alliance Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be active in microtubule cytoskeleton. Orthologous to human TBCA (tubulin folding cofactor A). FBgn0014455 FlyBase Gene Snapshot "Adenosylhomocysteinase (Ahcy) encodes S-adenosyl-L-homocysteine hydrolase, the rate-limiting enzyme in methionine metabolism. This tetrameric enzyme catalyzes the reversible hydrolysis of S-Adenosylhomocysteine (SAH) to adenosine and L-homocysteine. The function of Ahcy product is required to maintain proper concentrations of SAH, which serves as an inhibitor of S-adenosylmethionine-dependent methylation reactions." FBgn0030638 Alliance Predicted to enable sodium-dependent organic anion transmembrane transporter activity. Predicted to be involved in sodium-dependent organic anion transport. Predicted to be located in plasma membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in intestinal disease. Orthologous to several human genes including SLC10A5 (solute carrier family 10 member 5). FBgn0030643 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0030645 Alliance Predicted to contribute to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). FBgn0030647 Alliance Predicted to be involved in actin cytoskeleton organization. Predicted to be active in cytoplasm. FBgn0030648 Alliance "Located in nucleoplasm. Is expressed in several structures, including adult brain cell body rind; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to human RSRC2 (arginine and serine rich coiled-coil 2)." FBgn0027287 FlyBase Gene Snapshot "Golgi microtubule-associated protein (Gmap) encodes a peripheral Golgi protein that is required for the efficient trafficking within the early secretory pathway, probably by recruiting Rab proteins and effector molecules." FBgn0030653 UniProtKB "Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. (UniProtKB:Q9VXT7)" FBgn0030658 Alliance Predicted to be involved in protein folding. Located in endomembrane system. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human DNAJC25-GNG10 (DNAJC25-GNG10 readthrough) and DNAJC25 (DnaJ heat shock protein family (Hsp40) member C25). FBgn0030660 Alliance Predicted to enable tRNA binding activity. Predicted to be involved in tRNA C3-cytosine methylation. Is expressed in wing hinge primordium and wing pouch. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 86. Orthologous to human DALRD3 (DALR anticodon binding domain containing 3). FBgn0030661 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPI (alkaline phosphatase, intestinal) and ALPP (alkaline phosphatase, placental)." FBgn0030663 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human TCEA1 (transcription elongation factor A1); TCEA2 (transcription elongation factor A2); and TCEA3 (transcription elongation factor A3). FBgn0030664 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. FBgn0030666 Alliance "Is expressed in several structures, including anlage in statu nascendi; antennal anlage; ganglia; head epidermis primordium; and somatic precursor cell." FBgn0030668 Alliance Predicted to enable ADP-ribose diphosphatase activity; NAD binding activity; and NADH pyrophosphatase activity. Is expressed in adult head. Orthologous to human NUDT6 (nudix hydrolase 6). FBgn0030671 Alliance Involved in protein stabilization. Predicted to be active in early endosome. Orthologous to human F8A1 (coagulation factor VIII associated 1); F8A2 (coagulation factor VIII associated 2); and F8A3 (coagulation factor VIII associated 3). FBgn0030673 Alliance Is expressed in organism. FBgn0030672 Alliance "Predicted to enable ATP binding activity. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and gut section. Orthologous to human ABCF2-H2BK1 (ABCF2-H2BK1 readthrough) and ABCF2 (ATP binding cassette subfamily F member 2)." FBgn0030670 FlyBase Gene Snapshot "Phosphatidylinositol synthase (Pis) encodes an enzyme involved in the synthesis of phosphatidyl inositol, which is further modified to give rise to phosphorylated membrane lipids with multiple functions. It is important for membrane composition and Pis mutants develop various cellular polarity abnormalities, e.g. epithelial cells will misposition basement membrane proteins at their apical side, due to a lack of PIP2." FBgn0030669 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to be located in membrane. Predicted to be part of mitochondrial inner membrane peptidase complex. Is expressed in adult head; organism; and spermatozoon. Orthologous to human IMMP1L (inner mitochondrial membrane peptidase subunit 1). FBgn0003463 FlyBase Gene Snapshot short gastrulation (sog) encodes a secreted BMP antagonist that is expressed in the embryonic ventral neuroectoderm. sog product promotes neural development by preventing dorsally produced dpp from diffusing into the neuroectoderm and suppressing expression of neural genes. sog protein also diffuses dorsally where it helps establish a BMP activity gradient essential for partitioning that domain into cells giving rise to the dorsal epidermis versus amnioserosa. FBgn0030659 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including anterior endoderm anlage; cuboidal/columnar epithelium; foregut anlage in statu nascendi; and posterior ectoderm anlage." FBgn0030655 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Is expressed in organism. Orthologous to human CWF19L2 (CWF19 like cell cycle control factor 2)." FBgn0030654 Alliance Predicted to be involved in positive regulation of SREBP signaling pathway. Is expressed in organism. Orthologous to human SPRING1 (SREBF pathway regulator in golgi 1). FBgn0004391 FlyBase Gene Snapshot "shattered (shtd) encodes the largest subunit that forms the scaffold of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase. APC/C is active during mitosis and G1 phases of the cell cycle to mediates the degradation of cyclins and other key cell cycle regulators, which triggers the metaphase to anaphase transition and the exit from mitosis." FBgn0040285 Alliance Involved in long-term memory and neuromuscular synaptic transmission. Located in terminal bouton. Is expressed in adult head; larval ventral nerve cord; and motor neurons. Used to study autism spectrum disorder. Orthologous to several human genes including SCAMP1 (secretory carrier membrane protein 1). FBgn0030674 Alliance "Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including dsRNA transport; negative regulation of signal transduction; and regulation of axonogenesis. Located in nucleus. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)." FBgn0030675 Alliance Is expressed in organism. FBgn0026666 UniProtKB Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness (PubMed:22885802). (UniProtKB:Q8T3X9) FBgn0030679 Alliance "Predicted to enable protein folding chaperone and protein-folding chaperone binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; protein import into mitochondrial matrix; and protein stabilization. Predicted to be active in cytosol; mitochondrion; and nucleus. Is expressed in embryonic/larval midgut and organism." FBgn0027329 Alliance "Predicted to enable unfolded protein binding activity. Involved in centriole replication. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; germline cell; gut section; and mesoderm. Used to study intrinsic cardiomyopathy. Orthologous to several human genes including CCT6B (chaperonin containing TCP1 subunit 6B)." FBgn0030683 Alliance "Predicted to enable diphosphomevalonate decarboxylase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be active in cytosol. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; central brain anlage; central brain anlage in statu nascendi; and gut section. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase)." FBgn0030686 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 9. Orthologous to human MRPL3 (mitochondrial ribosomal protein L3). FBgn0030687 Alliance Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase III activity. Involved in positive regulation of transcription by RNA polymerase III and positive regulation of translation. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Orthologous to human POLR3A (RNA polymerase III subunit A). FBgn0053172 UniProtKB "Together with methyltransferase Trm7-34, methylates the 2'-O-ribose of nucleotides at position 34 of the anticodon loop of substrate tRNAs. (UniProtKB:Q86B53)" FBgn0030692 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion and ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; and gut section. Orthologous to human MRPS30 (mitochondrial ribosomal protein S30)." FBgn0026374 Alliance Predicted to be involved in negative regulation of stress fiber assembly. Orthologous to several human genes including RHPN1 (rhophilin Rho GTPase binding protein 1). FBgn0030694 Alliance Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission and mitotic cytokinesis checkpoint signaling. Predicted to be active in centrosome; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). FBgn0030696 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). FBgn0003345 FlyBase Gene Snapshot "scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification." FBgn0030697 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of mRNA processing and spliceosomal complex assembly. Predicted to be active in cytoplasm and nucleus. Orthologous to human SRPK2 (SRSF protein kinase 2). FBgn0030699 Alliance Enables small GTPase binding activity. Involved in adult somatic muscle development. Orthologous to several human genes including LRRFIP2 (LRR binding FLII interacting protein 2). FBgn0030700 UniProtKB Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34). (UniProtKB:Q9VXN0) FBgn0001105 FlyBase Gene Snapshot "G protein beta-subunit 13F (Gbeta13F) encodes an ubiquitous, maternal product required for gastrulation movements of early embryo and regulating medial (mesoderm and ectoderm) and junctional Myosin II (ectoderm) via RhoI pathway. The product of Gbeta13F is detected apically and at adherens junctions." FBgn0001092 FlyBase Gene Snapshot Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis. FBgn0030701 Alliance Predicted to be involved in morphogenesis of a branching epithelium. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human BTBD7 (BTB domain containing 7). FBgn0030704 Alliance Predicted to be involved in rRNA processing. Is expressed in organism. Orthologous to human RBFA (ribosome binding factor A). FBgn0003392 UniProtKB Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting. (UniProtKB:P27619) FBgn0030706 FlyBase Gene Snapshot LDL receptor related protein 4 (Lrp4) encodes a type I transmembrane protein that is enriched in presynaptic terminals and regulates synaptic organization in the olfactory circuit. FBgn0030707 Alliance "Predicted to enable neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alcoholic liver cirrhosis; amphetamine abuse; and epilepsy (multiple). Orthologous to several human genes including GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3); GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4); and GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5)." FBgn0030710 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. FBgn0030711 Alliance Predicted to enable DNA binding activity and RNA binding activity. Involved in regulation of gene expression. Part of exosome (RNase complex). Orthologous to human C1D (C1D nuclear receptor corepressor). FBgn0045073 FlyBase Gene Snapshot "Stromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight." FBgn0053180 UniProtKB May function as a nuclear transport receptor. (UniProtKB:Q9GQN0) FBgn0010315 FlyBase Gene Snapshot "Cyclin D (CycD) encodes a protein that binds to the product of Cdk4, thereby promoting its kinase activity. The CycD-Cdk4 complex promotes cell growth and progression through the G1 phase - it phosphorylates and thereby inhibits the product of Rbf, the ortholog of the human tumor suppressor retinoblastoma protein." FBgn0030703 Alliance "Enables ecdysone binding activity. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; dorsal head epidermis; embryonic/larval corpus allatum; and embryonic/larval midgut primordium. Orthologous to several human genes including PGRMC1 (progesterone receptor membrane component 1)." FBgn0065035 Alliance "Predicted to enable 2-oxoglutarate-dependent dioxygenase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity; and ferrous iron binding activity. Predicted to be involved in oxidative RNA demethylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; mesoderm; and posterior endoderm. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase)." FBgn0002914 FlyBase Gene Snapshot Myb oncogene-like (Myb) encodes a transcription factor that activates the transcription of genes involved in the G2/M phases of the cell cycle. This activation occurs by inhibition of the highly conseved MuvB multi-protein repressor complex. FBgn0026076 Alliance Is expressed in adult head. Orthologous to human UBL3 (ubiquitin like 3). FBgn0014391 UniProtKB "Activates the G-protein coupled receptor mth in vitro, leading to increased intracellular calcium ion levels. (UniProtKB:Q9VXN2)" FBgn0027093 UniProtKB Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (UniProtKB:Q9VXN4) FBgn0000319 FlyBase Gene Snapshot "Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles." FBgn0030695 FlyBase Gene Snapshot "Peptidoglycan recognition protein LE (PGRP-LE) encodes an intracellular protein that interacts with DAP-type peptidoglycan to activate the immune deficiency pathway, notably in the midgut." FBgn0052581 Alliance Predicted to enable ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding activity; and zinc ion binding activity. Involved in protein ubiquitination. Is active in endoplasmic reticulum. Orthologous to human RNF185 (ring finger protein 185). FBgn0030693 Alliance "Predicted to enable ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding activity; and zinc ion binding activity. Involved in positive regulation of ubiquitin-dependent protein catabolic process and protein ubiquitination. Is active in endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval muscle system; ganglia; and gut section. Orthologous to human RNF185 (ring finger protein 185)." FBgn0025809 Alliance Is expressed in adult abdomen; adult head; adult thorax; organism; and ovary. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2) and PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3). FBgn0030691 Alliance Involved in regulation of dendrite morphogenesis and synaptic assembly at neuromuscular junction. Located in dendrite; neuronal cell body; and terminal bouton. Colocalizes with microtubule. Is expressed in adult head and spermatozoon. Orthologous to human EFHC2 (EF-hand domain containing 2). FBgn0030688 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0030685 UniProtKB "GTPase-activating protein for Rho family proteins (PubMed:33835025). Essential component of the CLIC (clathrin-independent carrier)/GEEC (GPI-anchored protein-enriched early endocytic compartment) endocytic pathway (PubMed:28993397). During hematopoiesis, inhibits Egfr-ras-MAPK signaling by promoting Spi-induced Egfr internalization through CLIC/GEEC endocytosis, thereby preventing plasmatocyte overproliferation (PubMed:28993397). Essential for normal mushroom body (MB) development and consequently the formation of olfactory long-term memories (PubMed:33892766). During MD development, required to stop the MB beta-lobe from crossing the brain midline, possibly acting via its role in the CLIC/GEEC endocytic pathway to down-regulate the Egfr-ras-MAPK signaling at the tip of the beta-lobes (PubMed:33892766). Required during embryo cellularization for maintaining and regulating the rate of actomyosin ring constriction (PubMed:33835025). During cellularization, inhibits Rho-GTP levels at the furrow canal tip in a spatiotemporal manner, thus delaying the onset of actomyosin contraction and ensuring appropriate closure of the cells at the base of nuclei after membrane extension (PubMed:33835025). (UniProtKB:X2JDY8)" FBgn0030680 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. FBgn0030678 Alliance Predicted to be involved in positive regulation of mitochondrial translation. Predicted to be located in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 11. Orthologous to human RMND1 (required for meiotic nuclear division 1 homolog). FBgn0011741 Alliance Predicted to enable nucleosome binding activity. Involved in transcription initiation-coupled chromatin remodeling. Located in nucleus. Part of chromatin. Is expressed in organism. Orthologous to human ACTR6 (actin related protein 6). FBgn0030676 Alliance "Predicted to enable protein folding chaperone and protein-folding chaperone binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; protein import into mitochondrial matrix; and protein stabilization. Predicted to be active in cytosol; mitochondrion; and nucleus. Orthologous to human DNLZ (DNL-type zinc finger)." FBgn0003920 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in Cajal body." FBgn0030731 FlyBase Gene Snapshot peroxisomal Multifunctional enzyme type 2 (Mfe2) encodes a multifunctional protein harboring two separate enzyme activities: 2-enoyl-CoA hydratase 2 and 3-hydroxyacyl-CoA dehydrogenase. They function in the peroxisomal fatty acid breakdown spiral of beta-oxidation utilizing the (R)-isomer of the CoA-containing substrate. FBgn0004066 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:P22769)" FBgn0000536 UniProtKB Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. (UniProtKB:P54352) FBgn0030733 Alliance Involved in cellular respiration. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex III deficiency nuclear type 3. Orthologous to human UQCRB (ubiquinol-cytochrome c reductase binding protein). FBgn0030735 Alliance Predicted to enable phosphatase activity and protein phosphatase binding activity. Involved in negative regulation of BMP signaling pathway. Predicted to be active in cytoplasm and membrane. Is expressed in organism. Orthologous to several human genes including MTMR4 (myotubularin related protein 4). FBgn0027521 Alliance Is expressed in organism. FBgn0030739 FlyBase Gene Snapshot "Strumpellin and WASH-interacting protein (SWIP) encodes a protein that is part of the multi-subunit WASH regulatory complex (SHRC) to activate Arp2/3-mediated actin nucleation in a context-dependent manner. The product of SWIP, along with the SHRC, has been found to play a role in actin architecture and ooplasmic streaming during oogenesis, in endosome recycling, and in integrin-mediated cell spreading of hemocytes." FBgn0052579 Alliance Involved in plasma membrane phospholipid scrambling. Is active in plasma membrane. Is expressed in organism. Orthologous to several human genes including XKR6 (XK related 6) and XKR9 (XK related 9). FBgn0260450 FlyBase Gene Snapshot "Calpain C (CalpC) encodes one of four calcium-dependent cysteine proteases, but lack of conservation in the catalytic domain suggests it lacks proteolytic activity." FBgn0003416 FlyBase Gene Snapshot "small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway." FBgn0005411 FlyBase Gene Snapshot U2 small nuclear riboprotein auxiliary factor 50 (U2af50) encodes the large subunit of the heterodimeric complex U2AF. U2AF binds to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site early in spliceosome assembly. FBgn0030743 Alliance Predicted to be involved in mitochondrial respirasome assembly. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human HIGD2A (HIG1 hypoxia inducible domain family member 2A) and HIGD2B (HIG1 hypoxia inducible domain family member 2B). FBgn0030740 Alliance Is expressed in adult head and organism. FBgn0004432 UniProtKB PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (UniProtKB:P25007) FBgn0030738 Alliance "Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in nucleus. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1)." FBgn0030734 Alliance Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to human ERP44 (endoplasmic reticulum protein 44). FBgn0040207 Alliance "Predicted to enable microtubule binding activity. Involved in dorsal appendage formation. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and nurse cell. Used to study microcephaly. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1)." FBgn0003933 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0004598 UniProtKB Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (UniProtKB:P30432) FBgn0030745 Alliance Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in sarcoplasmic reticulum. Is expressed in adult head; adult heart; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and indirect flight muscle cell. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38A (transmembrane protein 38A) and TMEM38B (transmembrane protein 38B). FBgn0004367 FlyBase Gene Snapshot "meiotic 41 (mei-41) encodes a protein that, together with mus304, promotes DNA damage-dependent responses, including repair and cell cycle checkpoint signalling." FBgn0030747 Alliance Predicted to enable flippase activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia; autosomal dominant nonsyndromic deafness; and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A); ATP11B (ATPase phospholipid transporting 11B (putative)); and ATP11C (ATPase phospholipid transporting 11C). FBgn0030748 Alliance "Involved in positive regulation of lipophagy. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval garland cell; garland cell primordium; and gut section. Human ortholog(s) of this gene implicated in brain disease. Orthologous to several human genes including TRAF1 (TNF receptor associated factor 1); TRAF2 (TNF receptor associated factor 2); and TRAF3 (TNF receptor associated factor 3)." FBgn0030753 FlyBase Gene Snapshot rings lost (rngo) encodes a ubiquitin receptor that binds to ubiquitinated proteins via its ubiquitin-associated domain. It is an essential protein that is required for proper development of ring canals in the female germ line. FBgn0026181 FlyBase Gene Snapshot "Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis." FBgn0030752 Alliance Predicted to enable structural molecule activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to several human genes including TMEM30A (transmembrane protein 30A). FBgn0030749 Alliance "Predicted to enable calcium-dependent phospholipid binding activity; phosphatidylethanolamine binding activity; and phosphatidylserine binding activity. Predicted to be involved in response to calcium ion. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in several structures, including adult head; adult heart; dorsal epidermis primordium; embryonic anal pad; and gut section. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23 and inclusion body myopathy and brain white matter abnormalities. Orthologous to human ANXA11 (annexin A11) and ANXA7 (annexin A7)." FBgn0030746 Alliance Predicted to enable flippase activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia; autosomal dominant nonsyndromic deafness; and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A); ATP11B (ATPase phospholipid transporting 11B (putative)); and ATP11C (ATPase phospholipid transporting 11C). FBgn0010416 FlyBase Gene Snapshot TH1 (TH1) encodes one of four subunits that constitutes the NELF complex. The NELF complex along with DSIF causes RNA polymerase II to pause 20 to 50 nucleotides downstream from the transcription start site of most and possibly all actively transcribed genes in a process commonly called promoter proximal pausing. FBgn0030744 Alliance "Is expressed in several structures, including adult head; embryonic central brain neurons; embryonic/larval nervous system; ganglia; and lateral cord neurons." FBgn0010412 FlyBase Gene Snapshot Ribosomal protein S19a (RpS19a) encodes a structural constituent of ribosomes. FBgn0030766 FlyBase Gene Snapshot "methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway." FBgn0030776 Alliance Predicted to be involved in proteolysis. FBgn0052572 Alliance Is expressed in larval ventral nerve cord and spermatozoon. FBgn0052571 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0052570 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0052569 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0052574 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0030786 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including adult head; anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm. Orthologous to human MRPL22 (mitochondrial ribosomal protein L22)." FBgn0030788 UniProtKB Component of the class 1 Sin3A-histone deacetylase (HDAC1/Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle. (UniProtKB:Q9VXB3) FBgn0030790 Alliance Orthologous to human HAPSTR1 (HUWE1 associated protein modifying stress responses). FBgn0030792 Alliance "Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be active in endomembrane system. Is expressed in organism. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RABL3 (RAB, member of RAS oncogene family like 3)." FBgn0030794 Alliance "Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; mesoderm; and visceral muscle primordium." FBgn0030795 FlyBase Gene Snapshot pickpocket 28 (ppk28) encodes a member of the degenerin/epithelial Na[+] channel (pickpocket) gene family. It is an osmosensitive ion channel that mediates water taste detection. FBgn0030796 Alliance "Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in plasma membrane. Is expressed in several structures, including CNS glial cell; adult brain cell body rind; adult head; synaptic neuropil domain; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene)." FBgn0030799 Alliance Predicted to enable hormone binding activity; thiomorpholine-carboxylate dehydrogenase activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 40. Orthologous to human CRYM (crystallin mu). FBgn0030801 Alliance "Predicted to enable nucleotide binding activity. Involved in positive regulation of G protein-coupled receptor signaling pathway. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and ventral nerve cord primordium. Orthologous to human CRCP (CGRP receptor component)." FBgn0030803 Alliance Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in cellular response to misfolded protein. Is expressed in organism. FBgn0027556 Alliance Predicted to enable potassium channel regulator activity and transmembrane transporter activity. Involved in inorganic ion homeostasis and renal system process. Predicted to be active in plasma membrane and striated muscle dense body. Is expressed in adult head. Orthologous to human UNC93A (unc-93 homolog A). FBgn0030802 FlyBase Gene Snapshot Density regulated protein (DENR) encodes a non-canonical translation initiation factor together with its binding partner encoded by MCTS1. It associates with ribosomes and it promotes translation reinitiation. FBgn0030800 FlyBase Gene Snapshot "Nitrogen permease regulator-like 2 (Nprl2) encodes a component of the highly conserved GAP activity towards rags 1 (GATOR1) complex, which inhibits the product of mTor activity in response to amino acid starvation. The product of Nprl2, as well as the other GATOR1 components encoded by Nprl3 and Iml1, regulates early meiotic progression." FBgn0030798 Alliance Is expressed in embryonic proventriculus and head mesoderm. FBgn0030797 Alliance Is expressed in adult midgut progenitor cell; embryonic hindgut; embryonic/larval posterior spiracle; organism; and pole plasm. FBgn0030793 UniProtKB "Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Possesses 5'-pyrophosphohydrolase activity, hydrolyzing the 5'-end triphosphate to release pyrophosphates, and 5'-3' exonuclease activity (PubMed:27292797). May be involved in RNA degradation in the nucleus (PubMed:27292797). (UniProtKB:Q9VXA8)" FBgn0030791 UniProtKB May be involved in endocytosis. (UniProtKB:Q9VXB0) FBgn0030789 Alliance "Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Part of exosome (RNase complex). Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; mesoderm; and salivary gland body primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1D. Orthologous to human EXOSC9 (exosome component 9)." FBgn0030787 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human GTF3A (general transcription factor IIIA)." FBgn0001250 FlyBase Gene Snapshot "inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers." FBgn0027528 FlyBase Gene Snapshot gone early (goe) encodes a non-peptidase homolog of Neprilysin (M13) family metalloendopeptidases. It is expressed in various EGF (epidermal growth factor) ligand-producing cells and can attenuate EGFR signaling. The roles of the procut of goe include regulation of primordial germ cell differentiation and germline stem cell formation. FBgn0030777 Alliance Predicted to be involved in proteolysis. FBgn0030775 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human PRSS54 (serine protease 54). FBgn0030774 FlyBase Gene Snapshot "spheroide (sphe) encodes a serine protein homologue, a serine protease with no catalytic activity." FBgn0030773 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0030770 Alliance Is expressed in adult head. FBgn0030768 UniProtKB Contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for male and female fertility (PubMed:32923640). (UniProtKB:Q9VXD6) FBgn0030808 Alliance "Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in leg joint and spermatozoon. Orthologous to several human genes including ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1) and ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)." FBgn0030813 Alliance Is expressed in germline cell; organism; and primordial germ cell. FBgn0030816 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0030817 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen; adult head; adult thorax; and organism. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0000163 FlyBase Gene Snapshot "bazooka (baz) encodes a scaffold protein that forms a complex with the products of par-6 and aPKC and with other cortical, cytoskeletal and regulatory proteins. It functions in cell polarization pathways in epithelial, neuronal and other cell types." FBgn0052564 Alliance Predicted to enable transcription coactivator activity. Predicted to be a structural constituent of chitin-based cuticle. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chitin-based extracellular matrix. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adult head; embryonic anal pad; embryonic large intestine; hindgut proper primordium; and large intestine primordium. FBgn0030828 Alliance "Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0030829 Alliance Is expressed in organism. FBgn0030830 Alliance Is expressed in organism. FBgn0030823 Alliance Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cilium. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). FBgn0002590 FlyBase Gene Snapshot Ribosomal protein S5a (RpS5a) encodes a structural constituent of ribosomes. FBgn0065032 Alliance "Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in imaginal disc fusion, thorax closure. Predicted to be located in cytoskeleton. Predicted to be part of Arp2/3 protein complex. Is expressed in nurse cell ring canal and ovary. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3)." FBgn0030815 Alliance Predicted to enable zinc ion binding activity. Predicted to be active in extracellular space. FBgn0030812 FlyBase Gene Snapshot "wacky (wcy) encodes a protein involved in habituation, autophagy regulation and TORC1 signaling." FBgn0030809 UniProtKB "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (UniProtKB:Q9VX91)" FBgn0030806 Alliance Predicted to be involved in nervous system development and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing). FBgn0030805 FlyBase Gene Snapshot wurst (wus) encodes a transmembrane protein essential for clathrin-mediated endocytosis. It recruits the product of Hsc70-4 and clathrin to the apical cell membrane of epithelial cells. The endocytosis mediated by the product of wus is required for size determination and lumen clearance of the airways. FBgn0030838 Alliance Predicted to enable ubiquitin binding activity. Predicted to be involved in macroautophagy. Predicted to be active in phagophore assembly site. Is expressed in organism. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). FBgn0004854 UniProtKB "B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. (UniProtKB:Q24256)" FBgn0011758 UniProtKB "B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. (UniProtKB:Q24255)" FBgn0030839 Alliance Enables myosin binding activity. Predicted to be located in cytoplasm. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). FBgn0030841 Alliance "Is expressed in several structures, including embryonic head epidermis; embryonic head sensory system; embryonic hypopharynx; embryonic ventral epidermis; and epithelium." FBgn0030840 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0027602 UniProtKB Probable ATP-dependent RNA helicase. (UniProtKB:Q86B47) FBgn0024238 FlyBase Gene Snapshot Fimbrin (Fim) encodes an actin crosslinking protein involved in the remodelling and organisation of the actin cytoskeleton that occurs in processes such as cellularization and cell migration. FBgn0030834 Alliance Is expressed in wing disc. Orthologous to human C9orf85 (chromosome 9 open reading frame 85). FBgn0030833 Alliance Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Is expressed in adult head; germline cell; gonad; organism; and primordial germ cell. Orthologous to human YTHDC2 (YTH N6-methyladenosine RNA binding protein C2). FBgn0026313 FlyBase Gene Snapshot X11L (X11L) encodes a scaffolding protein that is important for eye development. It interacts with the products of rst and Appl and is required for targeting several proteins to cell membranes. FBgn0030853 Alliance "Predicted to enable oxidoreductase activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Orthologous to human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2)." FBgn0030855 Alliance "Predicted to enable RNA helicase activity. Involved in larval somatic muscle development. Predicted to be active in nucleus. Is expressed in several structures, including adult fat body; embryonic/larval midgut primordium; embryonic/larval muscle cell; mesoderm; and visceral mesoderm derivative. Orthologous to human DDX10 (DEAD-box helicase 10)." FBgn0026192 FlyBase Gene Snapshot "par-6 (par-6) encodes a scaffold protein that forms a complex with the products of baz and aPKC and with other cortical, cytoskeletal and regulatory proteins. It is involved in cell polarization, actin-based protrusion formation and tracheal branching." FBgn0024184 FlyBase Gene Snapshot "unc-4 (unc-4) encodes a homeodomain transcription factor expressed in distinct subsets of neurons in the embryonic and post-embryonic CNS. It regulates neuronal development and differentiation at least in part via repressing the expression of HGTX. It contributes to neuronal specification and differentiation, specifically axonal pathfinding and axongenesis." FBgn0026058 FlyBase Gene Snapshot Ods-site homeobox (OdsH) encodes a protein involved in male sterility. FBgn0030870 Alliance "Located in apical cortex. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal ectoderm anlage; gut section; and mesoderm." FBgn0000617 FlyBase Gene Snapshot TBP-associated factor 9 (Taf9) encodes a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. FBgn0030872 FlyBase Gene Snapshot "Ucp4A (Ucp4A) encodes a mitochondrial anion carrier that localizes to the mitochondrial inner membrane and can disrupt the proton gradient generated by the electron transport chain. It is expressed ubiquitously in adult flies, and plays a role in protecting mitochondria from oxidative stress." FBgn0052557 Alliance Predicted to enable ferroxidase activity. Predicted to be involved in iron ion transport. Predicted to be active in plasma membrane. FBgn0030873 Alliance "Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in ERAD pathway. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; gland; and salivary gland body primordium. Orthologous to human RNF121 (ring finger protein 121) and RNF175 (ring finger protein 175)." FBgn0030871 Alliance "Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair and DNA-templated DNA replication. Part of Elg1 RFC-like complex. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; ganglia; and mesoderm. Orthologous to human RFC4 (replication factor C subunit 4)." FBgn0030869 FlyBase Gene Snapshot "Suppressor of Cytokine Signaling at 16D (Socs16D) encodes a member of the SOCS family. It binds to the product of Pvr when catalytically active and is required for downstream activation of Target of Rapamycin Complex 1, but not the product of rl." FBgn0030864 Alliance "Predicted to enable protein serine/threonine kinase activity. Is expressed in several structures, including embryonic/larval lymph gland; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and mesoderm. Orthologous to human PBK (PDZ binding kinase)." FBgn0030859 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in adult head." FBgn0030858 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9VX31)" FBgn0026375 FlyBase Gene Snapshot Rho GTPase activating protein p190 (RhoGAPp190) encodes a Rho GTPase activating protein that binds the semaphorin receptor and regulates axonogenesis. FBgn0030854 Alliance "Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in heterochromatin formation. Predicted to be part of pericentric heterochromatin. Is expressed in several structures, including antennal anlage; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm." FBgn0030851 Alliance Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to human CCDC137 (coiled-coil domain containing 137). FBgn0030850 UniProtKB "Required in cholinergic neurons, but not in motor neurons, for normal neurotransmitter release by motor neurons. Involved in muscle growth. (UniProtKB:Q9VX39)" FBgn0028343 FlyBase Gene Snapshot "Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis." FBgn0030876 UniProtKB Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin (PubMed:33920774). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (By similarity). (UniProtKB:Q9VX10) FBgn0030878 Alliance "Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including embryonic/larval crystal cell; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and mesoderm. Used to study azoospermia. Orthologous to human ZNF622 (zinc finger protein 622)." FBgn0030880 Alliance Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in brain small vessel disease; cardiovascular system disease (multiple); congenital afibrinogenemia; end stage renal disease; and multiple myeloma. Orthologous to several human genes including FGB (fibrinogen beta chain); FGG (fibrinogen gamma chain); and FGL2 (fibrinogen like 2). FBgn0030882 FlyBase Gene Snapshot Glutathione synthetase 1 (Gss1) encodes an enzyme that catalyses the production of the cellular antioxidant glutathione by the condensation of gamma-glutamylcysteine and glycine. It is involved in cellular oxidative stress responses. FBgn0030884 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic anal pad; epithelium; gut section; sense organ; and tracheal branch primordium. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0030889 Alliance Predicted to enable beta-tubulin binding activity and microtubule binding activity. Is expressed in spermatogonium. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). FBgn0030891 FlyBase Gene Snapshot transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. FBgn0021765 FlyBase Gene Snapshot "scully (scu) encodes a mitochondrial protein that is part of a three protein complex responsible for cleaving the 5'-end of mitochondrial tRNAs. scu product forms a sub-complex with the protein encoded by rswl. This sub-complex binds the tRNA and recruits the metallonuclease encoded by mldr, which is responsible for cleaving the phosphodiester backbone of the RNA. Loss of scu results in lethality and aberrantly processed mtDNA transcripts." FBgn0030893 Alliance Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm. Is expressed in primary tracheal branch. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12); ARHGAP27 (Rho GTPase activating protein 27); and ARHGAP9 (Rho GTPase activating protein 9). FBgn0022724 UniProtKB TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (UniProtKB:Q9VWY6) FBgn0030895 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in eye. FBgn0030894 Alliance "Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to several human genes including MVB12A (multivesicular body subunit 12A)." FBgn0030890 Alliance "Predicted to enable inositol hexakisphosphate binding activity and phosphate transmembrane transporter activity. Predicted to be involved in cellular response to phosphate starvation and phosphate ion transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in several structures, including adult head; embryonic large intestine; embryonic/larval midgut primordium; foregut primordium; and gut section. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1)." FBgn0030883 Alliance Predicted to be involved in mitochondrial fission. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human MTFP1 (mitochondrial fission process 1). FBgn0030877 UniProtKB "Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). (UniProtKB:Q9VX09)" FBgn0083228 FlyBase Gene Snapshot Frequenin 2 (Frq2) encodes s protein that binds calcium and interacts with the guanyl exchange factor encoded by ric8a to regulate the number of synapses and the probability of neurotransmitter release per synapse. FBgn0030900 FlyBase Gene Snapshot "Holes in muscle (Him) encodes a protein that is expressed in developing mesoderm and myoblasts, as well as in pericardial cells. It binds the transcriptional corepressor encoded by gro to inhibit both muscle differentiation and Mef2 product activity. Him transcription is regulated by Notch signaling and the products of twi and tin." FBgn0030914 Alliance Predicted to enable allantoinase activity. Predicted to be involved in purine nucleobase catabolic process. Predicted to be active in cytoplasm. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. FBgn0030915 UniProtKB Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity. (UniProtKB:Q9VWV8) FBgn0022355 FlyBase Gene Snapshot Transferrin 1 (Tsf1) encodes an iron binding protein induced during the immune response. Iron sequestration is a classical host defense mechanism to combat bacterial infection. FBgn0030918 Alliance Predicted to be active in cytoplasm. FBgn0052548 Alliance Is expressed in adult head; embryonic/larval dorsal tracheal branch; embryonic/larval tracheal dorsal trunk; and embryonic/larval visceral tracheal branch. FBgn0052549 Alliance "Predicted to enable 5'-nucleotidase activity. Predicted to be involved in adenosine metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic epipharynx; and embryonic hypopharynx. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to several human genes including NT5C2 (5'-nucleotidase, cytosolic II)." FBgn0008635 FlyBase Gene Snapshot Coat Protein (coatomer) beta (betaCOP) encodes a subunit of the COPI coatomer complex required for retrograde transport of vesicles from the golgi to the endoplasmic reticulum. FBgn0004957 FlyBase Gene Snapshot porcupine (por) encodes an O-acyltransferase that is an essential component of the Wingless/Wnt pathway by mediating lipidation of the product of wg. It targets the product of wg to secretory vesicles that deliver the ligand to specialized microdomains at the cell surface where it can be packaged for secretion. FBgn0030913 Alliance Involved in locomotor rhythm. Is expressed in adult head. FBgn0030912 Alliance Is expressed in organism. FBgn0004956 FlyBase Gene Snapshot "unpaired 1 (upd1) encodes a secreted glycoprotein that is able to act at a distance as the primary ligand for the JAK/STAT signaling pathway. Although semi-redundant with upd2 and upd3, upd1 depletion results in embryonic lethality with an atypical gap gene-like segmentation phenotype." FBgn0030904 FlyBase Gene Snapshot unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. FBgn0030899 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES2 (hes family bHLH transcription factor 2) and HES4 (hes family bHLH transcription factor 4)." FBgn0030931 FlyBase Gene Snapshot X-ray repair cross complementing 2 (Xrcc2) encodes a protein involved in DNA repair. FBgn0027087 Alliance "Predicted to enable RNA binding activity and histidine-tRNA ligase activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Located in cytosol. Is expressed in adult gnathal ganglion; embryonic/larval muscle system; and supraesophageal ganglion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1) and HARS2 (histidyl-tRNA synthetase 2, mitochondrial)." FBgn0052546 Alliance Predicted to enable CCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0030943 UniProtKB Functions as a component of the nuclear pore complex (NPC) (By similarity). May have a role in the organization of the inner nuclear membrane proteins at the nuclear envelope together with Nup154 (PubMed:22718353). (UniProtKB:Q9VWS2) FBgn0001079 UniProtKB Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2. (UniProtKB:P23647) FBgn0004959 FlyBase Gene Snapshot "phantom (phtm) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It is an endoplasmic reticulum protein that catalyzes the addition of a hydroxyl group to the 25 carbon of the cholesterol side chain. phtm mutants fail to undergo head involution, dorsal closure and cuticle secretion." FBgn0030949 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VWR2) FBgn0030951 Alliance Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). FBgn0010383 FlyBase Gene Snapshot Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1. FBgn0030947 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). FBgn0030946 UniProtKB Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. (UniProtKB:Q9VWR8) FBgn0030945 Alliance Predicted to enable methylated histone binding activity. Involved in DNA repair-dependent chromatin remodeling. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Orthologous to human ING3 (inhibitor of growth family member 3). FBgn0030944 Alliance "Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval midgut; ganglia; and head epidermis primordium. Orthologous to human GID8 (GID complex subunit 8 homolog)." FBgn0027335 FlyBase Gene Snapshot "Rab11 interacting protein (Rip11) encodes a protein that belongs to Rab11 family interacting proteins (FIP family). It binds only to the GTP bound form of the product of Rab11, thus acting as its effector. It regulates Rhodopsin transport and cytokinesis." FBgn0030941 FlyBase Gene Snapshot "wengen (wgn) encodes a receptor for tumor necrosis factor (TNF) ligands, such as the product of egr. Signalling by this receptor is involved in apoptosis, photoreceptor axon guidance and nutritional control of body size." FBgn0030937 Alliance Is expressed in organism. FBgn0030933 Alliance Is expressed in adult head. FBgn0030932 FlyBase Gene Snapshot "gamma-glutamyl transpeptidase (Ggt-1) encodes an enzyme that transfers the gamma-glutamyl moiety from donors to substrates, e.g. transfer to water generates glutamate. The roles of the product of Ggt-1 include glutathione metabolism, reproduction and light avoidance." FBgn0010194 FlyBase Gene Snapshot "Wnt oncogene analog 5 (Wnt5) encodes a member of the Wnt gene family and acts as a signalling ligand for the Ryk family of receptor tyrosine kinase-related Wnt receptors. Among other processes, the product of Wnt5 contributes to repulsive embryonic axon pathfinding, mushroom body growth and antennal lobe patterning." FBgn0030930 UniProtKB "Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (PubMed:11925450, PubMed:12829714). In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:11925450). Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:11925450). Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure (PubMed:20807760). (UniProtKB:Q8MV48)" FBgn0030929 Alliance Is expressed in adult heart and embryonic proventriculus. FBgn0030928 Alliance Is expressed in embryonic midgut chamber; embryonic proventriculus; and embryonic/larval midgut. FBgn0030926 FlyBase Gene Snapshot "persephone (psh) encodes a hemolymphatic serine protease activated by microbial proteases during infection. It regulates Toll pathway activity upstream of the serine protease encoded by SPE, which cleaves the product of spz." FBgn0030925 FlyBase Gene Snapshot Hayan (Hayan) encodes a hemolymphatic serine protease involved in the activation of the melanization cascade. It is thought to directly cleave the prophenoloxidases encoded by PPO1 and/or PPO2. FBgn0030955 Alliance "Predicted to enable actin filament binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be active in cortical actin cytoskeleton and site of polarized growth. Predicted to colocalize with actin filament. Is expressed in several structures, including adult head; embryonic/larval muscle cell; embryonic/larval muscle system; posterior endoderm; and posterior midgut primordium. Orthologous to human COTL1 (coactosin like F-actin binding protein 1)." FBgn0030960 FlyBase Gene Snapshot "Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation." FBgn0030961 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Is expressed in embryonic brain and larval ventral nerve cord. FBgn0030963 Alliance Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in DNA-templated transcription. Predicted to be located in nucleus. Is expressed in embryonic brain and organism. FBgn0030964 FlyBase Gene Snapshot "PDGF- and VEGF-related factor 1 (Pvf1) encodes a PDGF- and VEGF-related factor that binds to and activates the receptor tyrosine kinase encoded by Pvr. It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner." FBgn0030969 Alliance "Predicted to enable zinc ion binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human USP39 (ubiquitin specific peptidase 39)." FBgn0030973 UniProtKB Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. (UniProtKB:Q9VWN5) FBgn0030975 Alliance "Predicted to enable succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be active in mitochondrial membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B)." FBgn0030976 Alliance Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in adult head and adult heart. Orthologous to several human genes including DUSP13B (dual specificity phosphatase 13B); DUSP26 (dual specificity phosphatase 26); and DUSP29 (dual specificity phosphatase 29). FBgn0030974 UniProtKB "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:29535189, PubMed:29555755). In the WMM complex, acts as a key regulator of m6A methylation by bridging fl(2)d to the RNA-binding component nito (PubMed:29535189). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:29535189, PubMed:29555755). (UniProtKB:Q9VWN4)" FBgn0030970 Alliance Predicted to enable ubiquitin protein ligase activity. Is expressed in organism. Orthologous to human UBE3D (ubiquitin protein ligase E3D). FBgn0030968 Alliance Predicted to enable L-xylulose reductase (NADPH) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Is expressed in adult head; adult heart; embryonic/larval fat body; and organism. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). FBgn0030966 UniProtKB "Required in ensheathing glial cells for normal larval locomotion. Oxidizes sulfite which is required to maintain glutamate homeostasis and as a consequence, neuronal network function. (UniProtKB:Q9VWP4)" FBgn0001090 UniProtKB May play an important role during development. (UniProtKB:P29746) FBgn0030959 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human POLDIP3 (DNA polymerase delta interacting protein 3). FBgn0030956 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human POLDIP3 (DNA polymerase delta interacting protein 3). FBgn0030954 FlyBase Gene Snapshot "Cholecystokinin-like receptor at 17D3 (CCKLR-17D3) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Dsk. It acts through the cAMP-PKA-CREB pathway and it is needed for the growth of neuromuscular junctions. It regulates food ingestion, satiety, hyperactivity, aggression and escape-related locomotion." FBgn0030991 Alliance Is expressed in adult head. FBgn0030992 Alliance Predicted to be active in plasma membrane. Is expressed in embryonic head epidermis; embryonic/larval visceral muscle cell; and visceral muscle primordium. FBgn0030993 Alliance "Involved in imaginal disc fusion, thorax closure and nephrocyte filtration. Predicted to be located in nephrocyte diaphragm. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Used to study kidney disease. Orthologous to human STOM (stomatin)." FBgn0030994 Alliance Predicted to enable chromatin binding activity. Predicted to be involved in chromosome organization. Predicted to be part of chromatin. Is expressed in germline cell and gonad. FBgn0030996 Alliance Is expressed in organism. Orthologous to human TMEM185A (transmembrane protein 185A) and TMEM185B (transmembrane protein 185B). FBgn0030999 Alliance "Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in several structures, including Malpighian tubule; embryonic/larval fat body; embryonic/larval posterior spiracle; embryonic/larval proventriculus; and embryonic/larval salivary gland." FBgn0031000 Alliance "Predicted to be an extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including embryonic/larval gut; embryonic/larval posterior spiracle; embryonic/larval salivary gland; epithelial tube; and gut section. Orthologous to human HCG22 (HLA complex group 22 (non-protein coding))." FBgn0031003 Alliance Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Is expressed in anterior endoderm; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase); FAM86B1 (family with sequence similarity 86 member B1); and FAM86B2 (family with sequence similarity 86 member B2). FBgn0031005 FlyBase Gene Snapshot Heparan sulfate 3-O sulfotransferase-B (Hs3st-B) encodes a heparan sulfate modifying enzyme that transfers a sulfate group to the 3-O position of glucosamine residues of heparan sulfate. It regulates adult midgut homeostasis. FBgn0040068 FlyBase Gene Snapshot Vav guanine nucleotide exchange factor (Vav) encodes a protein that belongs to the Dbl GEF superfamily. It functions as a GDP/GTP exchange factor for the product of Rac1 and an adaptor protein. Both activities are activated by direct tyrosine phosphorylation. FBgn0031012 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5). FBgn0031011 Alliance "Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in several structures, including adult fat body; adult head; dorsal epidermis primordium; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5)." FBgn0031010 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to several human genes including SLC16A11 (solute carrier family 16 member 11); SLC16A12 (solute carrier family 16 member 12); and SLC16A3 (solute carrier family 16 member 3). FBgn0052536 Alliance Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human EBAG9 (estrogen receptor binding site associated antigen 9). FBgn0031008 Alliance "Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and visceral mesoderm derivative." FBgn0031006 FlyBase Gene Snapshot "rapamycin-insensitive companion of Tor (rictor) encodes an essential component of TOR complex 2 where it controls phosphorylation of protein kinases, such as those encoded by Akt and trc. The product of rictor contributes to the regulation of tissue growth, dendritic tiling, long term memory, tolerance to heat stress, and mitochondrial quality control." FBgn0031004 Alliance Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; gastric caecum; and posterior midgut primordium. FBgn0031002 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5). FBgn0030998 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be active in plasma membrane. FBgn0027603 FlyBase Gene Snapshot Ulp1 (Ulp1) encodes a cysteine protease that catalyzes both SUMO maturation and SUMO deconjugation. It localizes to the nucleoplasmic face of the nuclear pore complex. Ulp1 knockdown in S2 cells results in relocalization of SUMO from the nucleus to the cytoplasm. FBgn0030997 Alliance Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. FBgn0030995 Alliance "Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Orthologous to human CYB5RL (cytochrome b5 reductase like)." FBgn0030990 Alliance Located in endomembrane system. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and testis. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). FBgn0030989 UniProtKB Structural component of the gap junctions. (UniProtKB:Q9VWL5) FBgn0030985 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0030982 Alliance Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in positive regulation of cell growth and regulation of barbed-end actin filament capping. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human MTPN (myotrophin). FBgn0031018 UniProtKB Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process (PubMed:30615609). Plays a role in DSBs processing into crossovers (PubMed:30615609). Plays a redundant role with nenya in chromosome segregation during female meiosis (PubMed:30615609). (UniProtKB:Q9VWI4) FBgn0031020 Alliance "Part of NatA complex. Is expressed in adult head. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit) and NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit)." FBgn0031021 UniProtKB "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (UniProtKB:Q9VWI0)" FBgn0027621 Alliance "Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; and positive regulation of glycolytic process through fructose-6-phosphate. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anlage in statu nascendi; cuboidal/columnar epithelium; embryonic/larval midgut primordium; and mesoderm. Orthologous to several human genes including PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) and PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4)." FBgn0031023 Alliance Predicted to be active in nucleus. FBgn0000257 FlyBase Gene Snapshot "carnation (car) encodes a subunit of the conserved HOPS complex, which is required for pigment granule formation and membrane fusion events, such as fusions between endosomes or autophagosomes with lysosomes. car loss of function mutant flies exhibit altered eye color." FBgn0031032 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in organism." FBgn0031034 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0031037 Alliance "Predicted to enable unfolded protein binding activity. Involved in protein refolding. Located in Z disc. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; embryonic/larval muscle cell; and synaptic neuropil domain." FBgn0031040 Alliance Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human CCDC86 (coiled-coil domain containing 86). FBgn0031044 UniProtKB Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response. (UniProtKB:Q9VWF4) FBgn0031045 Alliance "Predicted to enable phosphatase activity. Orthologous to human PHOSPHO2 (phosphatase, orphan 2)." FBgn0031047 Alliance "Involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. Is expressed in several structures, including adult central nervous system; adult muscle system; adult mushroom body; adult peripheral nervous system; and pupal/adult digestive system. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9)." FBgn0031049 UniProtKB Necessary for protein translocation in the endoplasmic reticulum. (UniProtKB:Q9VWE9) FBgn0031052 UniProtKB "Component of the nuclear pore complex (PubMed:28366641, PubMed:29773558). Binds to transcriptionally active chromatin including regulatory regions (PubMed:28366641, PubMed:31784359). (UniProtKB:Q9VWE6)" FBgn0031054 FlyBase Gene Snapshot Ssu72 CTD phosphatase (Ssu72) encodes an RNA polymerase II C-terminal domain (CTD) phosphatase. Its phosphatase activity is important for RNAPII transcription and termination and for gene looping. It may also be involved in the regulation of sister chromatid cohesion. FBgn0004057 FlyBase Gene Snapshot Glucose-6-phosphate dehydrogenase (G6pd) encodes a cytosolic enzyme that catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconate with the concomitant reduction of NADP+ to NADPH in the oxidative branch of the pentose phosphate pathway. FBgn0031057 FlyBase Gene Snapshot "Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy." FBgn0010341 FlyBase Gene Snapshot "Cell division cycle 42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, morphogenesis, hemocyte migration, cell polarity, and wound repair." FBgn0031059 Alliance Is expressed in organism. FBgn0031058 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0043903 FlyBase Gene Snapshot "Domeless (dome) encodes the transmembrane receptor for signalling ligands (encoded by upd1, upd2 and upd3) in the cytokine family, which utilises the intracellular JAK/STAT pathway. The product of dome is involved in growth, stem cells, immune responses and development." FBgn0031055 FlyBase Gene Snapshot eye transformer (et) encodes a type 1 cytokine receptor in the JAK/STAT pathway that behaves as a dominant negative receptor. It plays a key role in the larval hematopoietic organ the lymph gland under wasp parasitism. FBgn0031051 Alliance Predicted to enable RNA binding activity and nuclear export signal receptor activity. Predicted to be involved in RNA export from nucleus. Predicted to be part of RNA nuclear export complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung carcinoma (multiple); multiple myeloma; and primary ovarian insufficiency. Orthologous to human XPO5 (exportin 5). FBgn0031050 FlyBase Gene Snapshot Actin-related protein 10 (Arp10) encodes a component of the dynactin multiprotein complex that is involved in microtubule-based movement. FBgn0031048 Alliance "Predicted to enable phosphatase activity. Is expressed in adult head and organism. Orthologous to several human genes including PHOSPHO2 (phosphatase, orphan 2)." FBgn0031043 Alliance "Predicted to enable peptide alpha-N-acetyltransferase activity. Involved in negative regulation of neuron apoptotic process. Part of NatB complex. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; germline cell; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit)." FBgn0031042 Alliance Is expressed in spermatozoon. Orthologous to human NME9 (NME/NM23 family member 9). FBgn0031036 Alliance "Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Part of Sin3-type complex. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component)." FBgn0031033 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0031031 Alliance Is expressed in adult fat body. FBgn0031030 FlyBase Gene Snapshot "Tao (Tao) encodes a Ser/Thr kinase belonging to the Mst/Ste20 family. It is implicated in the Hippo and PAR-1 pathways. It contributes to restriction of tissue growth during development, regulation of microtubule dynamics, neuronal polarity, neural development, ethanol-stimulated behavioral response, and apoptosis." FBgn0026430 Interactive Fly "gamma-tubulin associated protein required for aspects of microtubule nucleation, dynamics and organization both in interphase and mitosis" FBgn0052532 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in organism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to several human genes including ESX1 (ESX homeobox 1); PROP1 (PROP paired-like homeobox 1); and RHOXF1 (Rhox homeobox family member 1)." FBgn0031026 Alliance Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human DESI2 (desumoylating isopeptidase 2). FBgn0027291 UniProtKB Probable catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. (UniProtKB:Q9VWH4) FBgn0040890 UniProtKB Involved in the early part of the secretory pathway. (UniProtKB:Q9VWH8) FBgn0020261 FlyBase Gene Snapshot "pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control." FBgn0044030 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult heart; anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 38. Orthologous to human MRPS14 (mitochondrial ribosomal protein S14)." FBgn0052533 Alliance "Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Is expressed in organism and spermatozoon. Orthologous to human DHX34 (DExH-box helicase 34)." FBgn0031062 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nuclear speck. Orthologous to human NOL8 (nucleolar protein 8)." FBgn0031064 Alliance Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to human SLC7A14 (solute carrier family 7 member 14). FBgn0010380 FlyBase Gene Snapshot "Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation." FBgn0031065 Alliance Predicted to be active in plasma membrane. Orthologous to human TMEM198 (transmembrane protein 198). FBgn0052528 FlyBase Gene Snapshot "parvin (parvin) encodes a Calponin-homology protein that, together with the products of Ilk and stck, reinforces integrin-matrix adhesion at muscle attachment sites in the developing embryo. The product of parvin contributes to cell adhesion and actin cytoskeleton organisation in muscles, wing and eye epithelial cells." FBgn0031068 Alliance "Predicted to enable flavin adenine dinucleotide binding activity and flavin-dependent sulfhydryl oxidase activity. Involved in tissue regeneration. Predicted to be active in mitochondrion. Is expressed in adult head; ectoderm; organism; and prothoracic leg disc. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration)." FBgn0031069 Alliance Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). FBgn0026174 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). FBgn0026175 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). FBgn0031078 UniProtKB "Plays a role in the nuclear pore complex (NPC) assembly and maintenance, but with limited role in NPC permeability. Required for specific nuclear import pathways such as Mad import. (UniProtKB:Q8IQV9)" FBgn0031077 FlyBase Gene Snapshot THADA (THADA) encodes a metabolic regulator that controls the balance between fat storage and heat production. It physically interacts with the ER calcium pump encoded by SERCA and regulates its activity to control metabolism. FBgn0031074 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). FBgn0031070 Alliance "Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain; and ventral nerve cord primordium. Orthologous to human CIP2A (cellular inhibitor of PP2A)." FBgn0042132 Alliance Predicted to enable 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in determination of adult lifespan. Orthologous to human TRIR (telomerase RNA component interacting RNase). FBgn0040089 Alliance "Involved in mesoderm development. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; embryonic/larval muscle system; mesoderm; and visceral mesoderm derivative." FBgn0031061 Alliance Predicted to enable fatty-acyl-CoA binding activity. Predicted to be active in Golgi membrane. Orthologous to several human genes including ACBD3 (acyl-CoA binding domain containing 3). FBgn0031060 UniProtKB Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (UniProtKB:Q9VWD6) FBgn0031066 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to several human genes including COX6B1 (cytochrome c oxidase subunit 6B1). FBgn0036936 Alliance Is expressed in chordotonal neurons. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 39. Orthologous to human LRRC56 (leucine rich repeat containing 56). FBgn0005198 FlyBase Gene Snapshot "gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways." FBgn0036945 FlyBase Gene Snapshot "Snakeskin (Ssk) encodes an occluding junction protein which, along with its counterpart Tetraspanin 2A (Tsp2A) and the cell adhesion protein mesh, is critical for the proper formation of invertebrate smooth septate junctions. Ssk shows highly enriched expression in the Malpighian (renal) tubules, midgut, and hindgut." FBgn0036950 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036953 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036956 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in embryonic/larval midgut. FBgn0036959 UniProtKB Supplies the nucleotide substrate for thymidylate synthetase. (UniProtKB:Q9VWA2) FBgn0024814 UniProtKB Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (UniProtKB:Q9VWA1) FBgn0036967 FlyBase Gene Snapshot Squamous cell carcinoma-related oncogene 4 (SCCRO4) encodes a protein involved in the regulation of protein neddylation. FBgn0036969 Interactive Fly "inhibits a protease cascade, involving the MP1 and MP2 proteases, that activates phenol oxidase, a key enzyme in melanin biosynthesis - inactivation and consequent tracheal melanization induces systemic expression of the antifungal peptide gene Drosomycin" FBgn0052225 Alliance Predicted to be involved in establishment of protein localization to organelle. Predicted to be located in membrane. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in adult head. Orthologous to human LAMP5 (lysosomal associated membrane protein family member 5). FBgn0036964 UniProtKB May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits (By similarity). May be involved in epigenetic regulation of muscle differentiation through regulation of the activity of the histone-lysine N-methyltransferase Suv4-20. (UniProtKB:Q9VWA8) FBgn0052227 FlyBase Gene Snapshot "golden goal (gogo) encodes a transmembrane protein involved in axonal pathfinding, especially in axon-axon and axon-target interactions." FBgn0036962 Alliance Predicted to enable microtubule binding activity. Predicted to be located in cilium. Predicted to be active in ciliary basal body. Is expressed in spermatozoon. Orthologous to human CFAP157 (cilia and flagella associated protein 157). FBgn0036958 Alliance Predicted to be active in nucleus. Orthologous to human CCDC82 (coiled-coil domain containing 82). FBgn0036952 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic proventriculus; embryonic/larval midgut; and gastric caecum. FBgn0036951 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic proventriculus. FBgn0036949 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036948 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic proventriculus. FBgn0036947 Alliance Predicted to enable chitin binding activity. Predicted to be located in chitin-based extracellular matrix. FBgn0036942 Alliance "Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut and organism. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase)." FBgn0036941 Alliance "Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase)." FBgn0036940 Alliance Predicted to enable chitin binding activity. Predicted to be located in chitin-based extracellular matrix. Is expressed in embryonic proventriculus. FBgn0036939 Alliance Predicted to enable calcium-independent phospholipase A2 activity and lysophospholipase activity. Predicted to be involved in phospholipid metabolic process. Orthologous to human PLB1 (phospholipase B1). FBgn0036938 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. FBgn0036937 FlyBase Gene Snapshot "Ionotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit." FBgn0036935 Alliance "Predicted to be involved in cilium assembly. Predicted to be active in ciliary transition zone. Is expressed in several structures, including Bolwig organ; adult head; embryonic head sensory system; embryonic/larval nervous system; and ganglia. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237)." FBgn0036934 FlyBase Gene Snapshot "short neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep." FBgn0036932 Alliance "Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Part of Ragulator complex. Is expressed in adult head. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)." FBgn0036909 Alliance "Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Is expressed in several structures, including adult heart; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human MIX23 (mitochondrial matrix import factor 23)." FBgn0024889 FlyBase Gene Snapshot karyopherin alpha1 (Kap-alpha1) encodes a protein that is involved in spermatogenesis and the nuclear import of the product of yki. FBgn0052221 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0001324 FlyBase Gene Snapshot "kohtalo (kto) encodes a subunit of the kinase module of the mediator complex. It is not required for all the transcriptional functions of mediator, but links it to a set of transcription factors that are involved in developmental signaling." FBgn0020389 FlyBase Gene Snapshot "PAPS synthetase (Papss) encodes an enzyme that catalyzes the synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the sulfate donor compound in all sulfotransferase reactions. Maternally provided Papss product is required for the formation of the embryonic dorsal-ventral axis mediated by the sulfotransferase encoded by pip." FBgn0036913 UniProtKB "Deubiquitinating enzyme that acts as an inhibitor of mitophagy probably by counteracting the action of park. Possibly functions by hydrolyzing ubiquitin attached by park on target proteins, thereby reducing park's ability to drive mitophagy. (UniProtKB:M9PD06)" FBgn0036915 FlyBase Gene Snapshot Precursor RNA processing 3 (Prp3) encodes a protein that regulates chromatin silencing. FBgn0028695 FlyBase Gene Snapshot "Regulatory particle non-ATPase 1 (Rpn1) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus." FBgn0036918 UniProtKB Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). (UniProtKB:Q9VW56) FBgn0036919 FlyBase Gene Snapshot Grasp65 (Grasp65) encodes a myristoylated Golgi protein that binds the product of GM130 and has been shown to mediate the Golgi bypass of transmembrane proteins. FBgn0036921 Alliance "Predicted to enable Rho GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha); ARHGDIB (Rho GDP dissociation inhibitor beta); and ARHGDIG (Rho GDP dissociation inhibitor gamma)." FBgn0004852 UniProtKB Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (UniProtKB:Q9VW60) FBgn0036925 Alliance Is expressed in adult head; elongation stage spermatid; gonad; and primary spermatocyte. FBgn0036926 Alliance Predicted to enable calcium ion binding activity. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A). FBgn0013303 UniProtKB "Calcium-binding protein that is essential for promoting night-time sleep and inhibiting nocturnal hyperactivity (PubMed:30865587, PubMed:7989365). During the night-time it promotes sleep by limiting synaptic output from arousal- and wake-promoting neurons within the C01- and A05- domains that include the mushroom body, and the antennal mechanosensory and motor center (PubMed:30865587). Regulated by the circadian clock network and light-sensing circuits that include the CRY photoreceptor; it is likely that both of these internal and external cues are required to define the temporal window (the night-time) during which this protein functions (PubMed:30865587). Inhibits the phosphorylation of rhodopsin in a calcium-dependent manner (PubMed:8626592). (UniProtKB:P42325)" FBgn0036928 Alliance "Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. Is active in mitochondrial outer membrane. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20)." FBgn0036929 Alliance Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain) and TNN (tenascin N). FBgn0036931 Alliance Predicted to enable ATP binding activity and ATP hydrolysis activity. Is expressed in spermatozoon. Orthologous to human IQCA1 (IQ motif containing with AAA domain 1) and IQCA1L (IQ motif containing with AAA domain 1 like). FBgn0036927 FlyBase Gene Snapshot "gamma-aminobutyric acid transaminase (Gabat) encodes an enzyme involved in the breakdown of the sleep-promoting neurotransmitter gamma-aminobutyric (GABA). It functions in mitochondria, in a shunt of the TCA cycle, and is implicated in the regulation of sleep as well as in metabolism." FBgn0005633 FlyBase Gene Snapshot "flightin (fln) encodes an indirect flight muscle specific protein, not expressed in other muscle types. It is required for the correct assembly of the myosin thick filament during flight muscle development in pupae. fln null mutants cannot fly and show a progressive flight muscle loss as adults. This loss is most likely caused by uncontrolled hypercontraction." FBgn0052220 FlyBase Gene Snapshot "CMP-sialic acid synthase (Csas) encodes an enzyme that catalyzes the transfer of CTP cytidylyl group to N-acetylneuraminate (NeuAc) to produce CMP-N-acetylneuraminate, a sugar donor required for the sialylation of glycoconjugates." FBgn0036924 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0036922 Alliance Predicted to be involved in negative regulation of smoothened signaling pathway. Predicted to be active in Golgi apparatus and ciliary membrane. Orthologous to human MOSMO (modulator of smoothened). FBgn0036920 Alliance Predicted to be involved in mitochondrial outer membrane translocase complex assembly. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human MTX2 (metaxin 2). FBgn0020887 FlyBase Gene Snapshot "Su(z)12 (Su(z)12) is a member of the Polycomb group of genes with products involved in transcriptional silencing. Su(z)12 encodes a subunit of Polycomb repressive complex 2 (PRC2), where it is required for the histone methyltransferase activity that yields trimethylation of histone H3 on lysine 27 (H3-K27me3)." FBgn0014037 FlyBase Gene Snapshot Su(Tpl) (Su(Tpl)) encodes a transcription elongation factor that enhances the catalytic rate of RNA Polymerase II by suppressing its transient pausing. It interacts with the product of lilli in the super elongation complex and the product of Ice1 in the little elongation complex. It regulates Notch and Ras signaling pathways. FBgn0003744 FlyBase Gene Snapshot "tricornered (trc) encodes a nuclear Dbf2-related kinase whose mutations lead to mulitpled hairs, split and multipled arista laterals and to defects in dendritic tiling." FBgn0023094 FlyBase Gene Snapshot cycle (cyc) is a circadian clock gene. It encodes a transcription factor of the BHLH-PAS family and activates transcription of key clock genes as well as downstream clock-regulated genes. FBgn0036910 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VW43) FBgn0036908 Alliance Predicted to enable ATPase regulator activity. Predicted to be involved in membrane organization. Part of nuclear membrane protein complex. Is active in nuclear envelope. Is expressed in adult head and organism. FBgn0036906 Alliance Predicted to enable SCF ubiquitin ligase complex binding activity. Is expressed in organism and spermatozoon. FBgn0036880 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0036881 FlyBase Gene Snapshot Cuticular protein 76Bd (Cpr76Bd) encodes a cuticle component involved in adult fly melanization. FBgn0260461 Alliance Involved in centrosome separation and spermatogenesis. Is expressed in spermatozoon. FBgn0036886 Alliance "Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including adult head; clypeo-labral primordium; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative. Orthologous to human NOL11 (nucleolar protein 11)." FBgn0036888 Alliance "Predicted to enable ATP binding activity. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human ABCF3 (ATP binding cassette subfamily F member 3)." FBgn0010417 FlyBase Gene Snapshot "TBP-associated factor 6 (Taf6) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it might be important for its stability. It forms a histone-like pair with the product of e(y)1. It is required during all stages of development, but particularly during imaginal disc development and gametogenesis." FBgn0036890 Alliance Is expressed in adult head; embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. FBgn0036891 Alliance "Enables serine hydrolase activity. Involved in response to fungus. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic/larval posterior spiracle; posterior spiracle primordium; and sensory nervous system primordium." FBgn0036893 Alliance Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human PIGF (phosphatidylinositol glycan anchor biosynthesis class F). FBgn0029094 UniProtKB "Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10591219, PubMed:12381660, PubMed:14561777, PubMed:16151251, PubMed:16396992). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11533245). Plays a role in the formation of silent heterochromatin (PubMed:12381660, PubMed:28320872). (UniProtKB:Q9V464)" FBgn0036895 FlyBase Gene Snapshot "male sterile (3) 76Cc (ms(3)76Cc) encodes a protein which contains multiple copies of a VTD-type deubiquitinase domain. It is most likely inactive, since crucial active site residues are missing." FBgn0004623 FlyBase Gene Snapshot "G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit . The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit." FBgn0036905 FlyBase Gene Snapshot "Viral tegument-like deubiquitinase (Vtld) encodes a deubiquitinating enzyme (DUB) of the VTD-type, related to herpesviral tegument proteins. Vtld exhibits deubiquitination activity towards K48-linked chains, and has multiple homologs in C. elegans, which also show a male-specific expression." FBgn0036899 FlyBase Gene Snapshot teyrha-meyrha (tey) encodes a nuclear protein that regulates neuromuscular target specificity partly by repressing the expression of Tl in specific muscles. FBgn0022774 Alliance Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate; arginine catabolic process to proline via ornithine; and ornithine metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). FBgn0036897 Alliance "Predicted to enable poly-ADP-D-ribose binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein destabilization. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human RNF146 (ring finger protein 146)." FBgn0036896 FlyBase Gene Snapshot "wallenda (wnd) encodes a kinase in the mixed lineage family of MAP Kinase Kinase Kinases. Its roles include axonal injury signaling (it becomes activated in neurons after axotomy), and in regulation of the structure of presynaptic boutons." FBgn0036892 FlyBase Gene Snapshot "Lon protease (Lon) encodes a conserved ATP-stimulated serine protease. It is encoded in the nucleus and targeted to the mitochondrial matrix, where it contributes to mitochondrial protein turnover." FBgn0020277 FlyBase Gene Snapshot "lush (lush) encodes a member of the odorant/pheromone-binding protein family. It is required for normal sensitivity to the male pheromone, 11-cis vaccenyl acetate." FBgn0005386 FlyBase Gene Snapshot "absent, small, or homeotic discs 1 (ash1) encodes a histone methyltransferase involved in transcription regulation." FBgn0036889 UniProtKB "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1580 (Gm1580) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2'-O-methyluridine at position 1579 (Um1579) mediated by MRM2. (UniProtKB:Q9VW14)" FBgn0036887 Alliance Predicted to be involved in cellular response to hypoxia; positive regulation of apoptotic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to be located in cytosol and mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; gastric caecum; and organism. Orthologous to human FAM162A (family with sequence similarity 162 member A) and FAM162B (family with sequence similarity 162 member B). FBgn0005564 FlyBase Gene Snapshot "Shaker cognate l (Shal) encodes a voltage-dependent A-type K[+] channel. It contributes to neuronal excitability, regulating synaptic plasticity, locomotion, learning, and lifespan." FBgn0036882 FlyBase Gene Snapshot Dctn1-related (Dred) encodes a protein with homology to human DCTN1 and fly DCTN1-p150. Dred is required in muscle and neurons for motor function. FBgn0040075 UniProtKB "Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (UniProtKB:Q9V3K3)" FBgn0036856 UniProtKB "Catalytic subunit of a heterodimer with Trmt112, which specifically methylates the 6th position of adenine in 18S rRNA. (UniProtKB:Q8MSW4)" FBgn0036859 Alliance Orthologous to human KIAA0825 (KIAA0825). FBgn0036860 Alliance Orthologous to human TMEM72 (transmembrane protein 72). FBgn0028380 FlyBase Gene Snapshot falten (fal) encodes a protein with potential GTPase activity. It is expressed in the mesoderm and is elevated in embryos lacking how function. FBgn0036868 Alliance Involved in spermatogenesis. FBgn0003089 FlyBase Gene Snapshot pipe (pip) encodes a sulfotransferase that contributes to the formation and polarity of the embryonic dorsal-ventral axis. FBgn0036862 Alliance Enables protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A) and PPP1R3D (protein phosphatase 1 regulatory subunit 3D). FBgn0036858 Alliance Predicted to be involved in proteolysis. FBgn0036857 Alliance Predicted to enable aldehyde dehydrogenase (NAD+) activity. Is expressed in adult head; adult heart; border follicle cell; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 4. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1). FBgn0017578 FlyBase Gene Snapshot "Max (Max) encodes a member of the basic-helix-loop-helix-zipper family of transcription factors. It specifically forms heterodimers with the products of Myc and Mnt enabling the binding and transcriptional activity of the heterodimeric complex, which regulate genes involved in cell and organismal growth." FBgn0026630 FlyBase Gene Snapshot nessy (nes) encodes a lysophospholipid acyltransferase that is required redundantly with the product of oys for germ cell migration and spermatid individualization. FBgn0036853 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL21 (mitochondrial ribosomal protein L21). FBgn0036834 UniProtKB Probable transporter. (UniProtKB:Q9VVV2) FBgn0036835 Alliance Is expressed in photoreceptor neurons. FBgn0036843 UniProtKB Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. (UniProtKB:Q9VVW3) FBgn0036846 Alliance Is expressed in organism and spermatozoon. Orthologous to human C5orf22 (chromosome 5 open reading frame 22). FBgn0036849 Alliance Predicted to enable myosin light chain binding activity. Predicted to be involved in spermatogenesis. Predicted to be located in sperm head-tail coupling apparatus. Orthologous to several human genes including SPATA6L (spermatogenesis associated 6 like). FBgn0016797 UniProtKB "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. (UniProtKB:Q9VVX3)" FBgn0052203 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0036850 FlyBase Gene Snapshot Gemin 2 (Gem2) encodes a member of the SMN-Gemins complex and a component of the cytoplasmic U snRNP body. It is required in the motor system for viability and motor behaviour. FBgn0036848 UniProtKB "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (UniProtKB:Q9VVW8)" FBgn0036847 Alliance Enables protein-folding chaperone binding activity. Involved in chaperone-mediated protein folding. Located in endomembrane system. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 60. Orthologous to several human genes including CNPY4 (canopy FGF signaling regulator 4). FBgn0036844 FlyBase Gene Snapshot Mitogen-activated protein kinase phosphatase 3 (Mkp3) encodes a member of the mitogen-activated protein kinase phosphatases that inactivate MAPKs. It dephosphorylates the phosphorylated active forms of the products of p38a and rl. FBgn0036842 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0015586 FlyBase Gene Snapshot Accessory gland protein 76A (Acp76A) encodes a protein that shows homology to the serpin serine endopeptidase inhibitor family but is predicted to be non-inhibitory. It is produced in the male accessory glands and transferred to females during mating. FBgn0002945 UniProtKB Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification. (UniProtKB:Q9VVV9) FBgn0036839 Alliance Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Is expressed in adult head; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. FBgn0036838 Alliance "Predicted to enable mRNA binding activity and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Predicted to be involved in RNA processing. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; longitudinal visceral muscle primordium; and trunk mesoderm. Orthologous to human TRMT2A (tRNA methyltransferase 2 homolog A)." FBgn0036837 Alliance "Enables myosin binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; amnioserosa; embryonic anal pad; embryonic/larval midgut; and sense organ. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1)." FBgn0036836 Alliance Predicted to enable glycerophosphocholine phosphodiesterase activity. Predicted to be involved in glycerophospholipid catabolic process. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1). FBgn0052204 Alliance "Is expressed in several structures, including CNS glial cell; embryonic central brain; embryonic central brain neurons; embryonic/larval nervous system; and ganglia." FBgn0036833 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Is expressed in organism. Orthologous to human EXOG (exo/endonuclease G). FBgn0036801 FlyBase Gene Snapshot Myosin phosphatase targeting subunit 75D (MYPT-75D) encodes a protein phosphatase 1 binding protein involved in myosin phosphatase regulation. FBgn0040323 FlyBase Gene Snapshot "Gram-negative bacteria binding protein 1 (GNBP1) encodes a hemolymphatic protein that participates together with the product of PGRP-SA in the activation of the Toll pathway by peptidoglycans, a cell-wall component of bacteria." FBgn0036807 Alliance "Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; phosphate ion transmembrane transport; and thiosulfate transport." FBgn0036810 Alliance Is expressed in dorsal ectoderm anlage; organism; and ventral ectoderm anlage. FBgn0036811 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). (UniProtKB:Q9VVS4)" FBgn0036813 FlyBase Gene Snapshot "Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy." FBgn0036815 FlyBase Gene Snapshot HP1-HOAP-interacting protein (HipHop) encodes a protein that interacts with the products of cav and Su(var)205. It is involved in telomere capping. FBgn0052027 Alliance Is expressed in organism. FBgn0036817 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0036819 UniProtKB "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses (PubMed:20015953, PubMed:28317021). In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes (PubMed:28317021). (UniProtKB:Q9VVT5)" FBgn0036820 FlyBase Gene Snapshot Glutaredoxin 1 (Grx1) encodes a protein involved in copper ion homeostasis. FBgn0014075 FlyBase Gene Snapshot UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr. FBgn0036822 UniProtKB "Effector of non-apoptotic necrotic cell death that mediates plasma membrane rupture (cytolysis): oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules that propagate the inflammatory response (PubMed:33472215). Also acts as a homophilic transmembrane adhesion molecule that promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity). (UniProtKB:Q9VVT9)" FBgn0036825 FlyBase Gene Snapshot Ribosomal protein L26 (RpL26) encodes a protein component of large ribosomal subunits. FBgn0036827 Alliance "Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human CIR1 (corepressor interacting with RBPJ, CIR1)." FBgn0036828 Alliance "Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; larval imaginal tissue; and trunk mesoderm. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6)." FBgn0036831 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). FBgn0036832 Alliance Predicted to be involved in proteolysis. FBgn0036830 Alliance "Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2)." FBgn0036829 Alliance Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult antennal sense organ; adult olfactory receptor neuron Ir75d; antenna; antennal lobe glomerulus VL1; and spermatozoon. FBgn0027057 FlyBase Gene Snapshot COP9 signalosome subunit 1b (CSN1b) encodes the subunit 1 of the COP9 signalosome (CSN) and is essential for the stability of the complex. The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. FBgn0036826 FlyBase Gene Snapshot "asterix (arx) encodes a nuclear protein required for fertility. It plays an essential role in piRNA-guided transcriptional silencing, interacting probably directly with the product of piwi." FBgn0036824 Alliance "Predicted to enable 2-methylbutanoyl-CoA dehydrogenase activity. Located in cytosol and mitochondrion. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; embryonic/larval muscle cell; and gut section. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain)." FBgn0036821 Alliance "Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; larval imaginal tissue; and sense organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1); ACSL5 (acyl-CoA synthetase long chain family member 5); and ACSL6 (acyl-CoA synthetase long chain family member 6)." FBgn0025807 FlyBase Gene Snapshot "Rad9 (Rad9) encodes a protein that, together with the Rad1 and Hus1-like products, forms the 9-1-1 checkpoint protein complex. This complex plays a central role in the DNA damage-induced checkpoint response." FBgn0036816 FlyBase Gene Snapshot "I'm not dead yet (Indy) encodes a plasma membrane transporter of Krebs cycle intermediates (citrate, succinate, fumarate, alpha-ketoglutarate) of the SLC13A family that is important in organismal intermediary metabolism. Mutations in Indy create a favorable metabolic state, similar to calorie restriction, and extend life span." FBgn0036814 Alliance Predicted to enable transcription corepressor activity. Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome; dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCORL1 (BCL6 corepressor like 1). FBgn0001078 UniProtKB Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand. (UniProtKB:P33244) FBgn0036812 FlyBase Gene Snapshot Nufip (Nufip) encodes an adaptor protein for the assembly of RiboNucleo-Particles (RNPs) such as the small nuclear RNP U4 (snRNP U4; part of the spliceosome) and the mRNPs encoding seleno-proteins. It is necessary for the biogenesis of the small nucleolar RNPs (snoRNPs). FBgn0036809 Alliance Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1); MKRN2 (makorin ring finger protein 2); and MKRN3 (makorin ring finger protein 3). FBgn0036808 FlyBase Gene Snapshot Dicarboxylate carrier 4 (Dic4) encodes a protein of the inner mitochondrial membrane. It belongs to a subfamily of mitochondrial dicarboxylate carriers but it doesn't catalyse an exchange for malate or phosphate. FBgn0036806 Alliance "Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1)." FBgn0036805 FlyBase Gene Snapshot "Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm." FBgn0036804 FlyBase Gene Snapshot "SAGA associated factor 11kDa (Sgf11) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Sgf11 is a component of the deubiquitinase module, interacts with the non-stop deubiquitinase, and is essential for non-stop enzymatic activity in vitro." FBgn0040322 UniProtKB "Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity). (UniProtKB:Q9VVR4)" FBgn0042134 FlyBase Gene Snapshot "Caprin (Capr) encodes an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs." FBgn0036791 Alliance "Is expressed in several structures, including anterior endoderm anlage; hindgut anlage; inclusive hindgut primordium; mesoderm; and midline primordium." FBgn0036795 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in sexual reproduction. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and spermatozoon. FBgn0036796 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. FBgn0052201 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum. FBgn0052199 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0052200 Alliance Predicted to enable CCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0013717 FlyBase Gene Snapshot "non-stop (not) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. It deubiquitinates the product of His2B at active promoters, thereby promoting transcription elongation. It was first identified for its role in neural development in the optic lobe." FBgn0003683 Alliance "Is expressed in several structures, including antennal anlage; anterior endoderm anlage; central brain anlage; dorsal head epidermis anlage; and mesoderm." FBgn0028416 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0028415 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0036787 Alliance Predicted to enable gamma-glutamylcyclotransferase activity. Located in extracellular region. Is expressed in eye and yolk nucleus. Orthologous to human GGCT (gamma-glutamylcyclotransferase). FBgn0052196 Alliance Predicted to enable gamma-glutamylcyclotransferase activity. Orthologous to human GGCT (gamma-glutamylcyclotransferase). FBgn0036786 FlyBase Gene Snapshot sickle (skl) encodes a member of the inhibitor of apoptotic protein antagonists. It is partially involved in the apoptosis of some larval neurons during metamorphosis. FBgn0011706 FlyBase Gene Snapshot "reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1." FBgn0036774 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human MRPS26 (mitochondrial ribosomal protein S26)." FBgn0002901 UniProtKB DNA damage checkpoint protein required for chromosome break repair and for genomic stability during development. (UniProtKB:Q9VVN4) FBgn0036777 Alliance Is expressed in organism. FBgn0052195 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0020300 Alliance "Involved in behavioral response to ethanol and sensory perception of smell. Is expressed in several structures, including adult tracheal system; amnioserosa anlage; epithelium; gut section; and organism subdivision." FBgn0036780 Alliance Is expressed in adult fat body. FBgn0015946 FlyBase Gene Snapshot "grim (grim) encodes a member of the inhibitor of apoptotic protein antagonists. In response to death signals, it induces apoptosis of cells in the central nervous system. It is important particularly for the apoptosis of specific juvenile neurons during metamorphosis." FBgn0036784 Alliance Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Is expressed in adult head and spermatozoon. Orthologous to several human genes including TKT (transketolase) and TKTL2 (transketolase like 2). FBgn0003997 UniProtKB "Activator of apoptosis, with grim and rpr, that acts on the effector Dredd (PubMed:22615583, PubMed:9740659). Seems to act genetically upstream of baculoviral anti-apoptotic p35 (PubMed:7622034). Blocks Diap2 from binding and inactivating the effector caspase Drice (PubMed:18166655). Might regulate apoptosis downstream of Clbn/NEMF (PubMed:22964637). (UniProtKB:Q24106)" FBgn0036781 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0036778 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VVN6) FBgn0036775 Alliance Predicted to enable DNA binding activity. Predicted to be involved in tRNA transcription by RNA polymerase III. Predicted to be part of RNA polymerase III complex. Is expressed in organism and spermatozoon. Orthologous to human POLR3D (RNA polymerase III subunit D). FBgn0036773 Alliance "Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic anal pad; embryonic head epidermis; and gut section." FBgn0052194 Alliance Is expressed in embryonic/larval midgut. FBgn0001134 UniProtKB "GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels. (UniProtKB:Q24352)" FBgn0036763 FlyBase Gene Snapshot "Tryptophanyl-tRNA synthetase, mitochondrial (TrpRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of tryptophan to its cognate tRNA to form tryptophanyl-tRNA." FBgn0036765 Alliance Involved in defense response to bacterium. Is expressed in adult head. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); ARSI (arylsulfatase family member I); and ARSJ (arylsulfatase family member J). FBgn0036768 Alliance Predicted to enable sulfuric ester hydrolase activity. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to several human genes including ARSB (arylsulfatase B). FBgn0036771 Alliance Predicted to enable protein domain specific binding activity and ubiquitin binding activity. Predicted to be involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Predicted to be part of calcineurin complex. Is expressed in chordotonal neurons; chordotonal organ; chordotonal organ precursor cell; and male germline cell. Orthologous to human DNAAF10 (dynein axonemal assembly factor 10). FBgn0052192 Alliance Is expressed in adult head. FBgn0000568 FlyBase Gene Snapshot "Ecdysone-induced protein 75B (Eip75B) encodes a nuclear receptor that interacts with the receptor encoded by Hr3. The product of Eip75B regulates feeding behavior, fat deposition, and developmental timing in response to nitric oxide (NO) signaling. It also acts downstream from NO in the nervous system, where it controls neuronal remodeling." FBgn0036772 Alliance "Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human TTC27 (tetratricopeptide repeat domain 27)." FBgn0036770 Alliance "Enables calcium ion transmembrane transporter activity; inorganic anion transmembrane transporter activity; and organic anion transmembrane transporter activity. Involved in several processes, including bicarbonate transport; carboxylic acid transport; and sulfate transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); bone disease (multiple); calcium oxalate nephrolithiasis; and diarrhea (multiple). Orthologous to several human genes including SLC26A4 (solute carrier family 26 member 4); SLC26A5 (solute carrier family 26 member 5); and SLC26A6 (solute carrier family 26 member 6)." FBgn0036769 FlyBase Gene Snapshot "Tetraspanin 74F (Tsp74F) encodes encodes a tetraspanin, which spans the membrane four times. When the products of both Tsp74F and Tsp66E are removed, this results in defects in actin polarization, endocytosis, and distribution of the integrin subunit encoded by if during oogenesis." FBgn0036766 Alliance Is expressed in adult head and adult heart. FBgn0036764 Alliance "Predicted to enable L-arginine transmembrane transporter activity; L-lysine transmembrane transporter activity; and L-ornithine transmembrane transporter activity. Predicted to be involved in L-arginine import across plasma membrane and L-ornithine transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; and visceral muscle primordium. Orthologous to human SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3)." FBgn0036761 FlyBase Gene Snapshot Mediator complex subunit 19 (MED19) encodes a conserved nuclear protein that acts as a hinge in the flexible mediator transcription complex associated with RNA polymerase II. FBgn0036760 Alliance "Predicted to enable phosphatase activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle cell. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase)." FBgn0036759 Alliance Predicted to enable phosphatase activity. Predicted to be active in cytoplasm. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). FBgn0036757 UniProtKB Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a. (UniProtKB:Q9VVL1) FBgn0036756 Alliance "Predicted to enable transmembrane transporter activity. Involved in determination of adult lifespan; regulation of JNK cascade; and response to oxidative stress. Located in several cellular components, including apical plasma membrane; late endosome; and microvillus membrane. Is expressed in adult head and organism. Used to study neuronal ceroid lipofuscinosis 1. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin)." FBgn0052191 Alliance Predicted to enable sulfuric ester hydrolase activity. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); ARSI (arylsulfatase family member I); and ARSJ (arylsulfatase family member J). FBgn0036754 UniProtKB "Part of a translational control module, also containing pths/DDX47 and ath/DHX33, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation (PubMed:35413237). Controls cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as non1 (PubMed:35413237). Involved in rRNA maturation or pre-rRNA processing during ribosome biogenesis (PubMed:35628496). (UniProtKB:Q9VVK8)" FBgn0052190 FlyBase Gene Snapshot NUCB1 (NUCB1) encodes a protein involved in the defense response to Gram-negative bacteria. FBgn0036732 UniProtKB "Transporter that mediates the cellular uptake of ecdysteroids, including ecdysone, from the hemolymph. (UniProtKB:Q9VVH9)" FBgn0052185 FlyBase Gene Snapshot "elevated during infection (edin) encodes a short secreted peptide involved in humoral immune response. Its expression is strongly induced upon bacterial, viral and wasp stimulation as well as in other stress situations. It is required in the fat body for a normal encapsulation against parasitoid wasps by the larval hemocytes." FBgn0036734 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition. Part of precatalytic spliceosome. Is expressed in adult head. Orthologous to several human genes including LUC7L (LUC7 like). FBgn0036738 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0036741 Alliance Involved in imaginal disc-derived wing vein morphogenesis and negative regulation of BMP signaling pathway. Predicted to be located in membrane. Is expressed in adult head; amnioserosa; embryonic/larval fat body; organism; and yolk nucleus. Orthologous to human GPR155 (G protein-coupled receptor 155). FBgn0036742 Alliance "Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma (multiple); asthma, nasal polyps, and aspirin intolerance; autoimmune disease (multiple); and blood platelet disease. Orthologous to several human genes including PTGIR (prostaglandin I2 receptor)." FBgn0036745 Alliance Enables glutathione disulfide oxidoreductase activity. Predicted to be involved in cell redox homeostasis. Located in endoplasmic reticulum and nucleus. Is expressed in adult head. Orthologous to human SELENOF (selenoprotein F). FBgn0052183 Alliance Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in cell adhesion; positive regulation of cell differentiation; and signal transduction. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in arthropathy; high grade glioma; and progressive pseudorheumatoid arthropathy of childhood. Orthologous to several human genes including CCN1 (cellular communication network factor 1); CCN2 (cellular communication network factor 2); and CCN5 (cellular communication network factor 5). FBgn0036749 Alliance Predicted to enable polyamine oxidase activity. Is expressed in adult head. Orthologous to human SMOX (spermine oxidase). FBgn0052182 Alliance Is expressed in spermatozoon. FBgn0036752 FlyBase Gene Snapshot "Adenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection." FBgn0043025 FlyBase Gene Snapshot Adenosine deaminase-related growth factor A2 (Adgf-A2) encodes a growth factor involved in spermatid development. FBgn0036751 Alliance Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). FBgn0036750 Alliance Predicted to enable polyamine oxidase activity. Orthologous to human SMOX (spermine oxidase). FBgn0036747 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). FBgn0036746 FlyBase Gene Snapshot "CREB-regulated transcription coactivator (Crtc) encodes a highly conserved transcriptional coactivator of cAMP-response element-binding protein (CREB). Its nuclear localization is regulated by several factors including intracellular cAMP or calcium levels, or calcineurin. Sik family kinases also phosphorylate to inhibit the product of Crtc and, consequently, control energy homeostais and lipid metabolism." FBgn0052179 FlyBase Gene Snapshot Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. FBgn0004401 UniProtKB "May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci. (UniProtKB:P41073)" FBgn0036740 FlyBase Gene Snapshot Vacuolar protein sorting 60 (Vps60) encodes a member of the Vps4 complex. It contributes to the formation of intraluminal vesicles and multi-vesicular bodies by supporting the dissociation of the ESCRT complex from the invaginating membranes on endosomes. FBgn0023197 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0036735 UniProtKB "In the process of mRNA degradation, may play a role in mRNA decapping. (UniProtKB:Q9VVI2)" FBgn0036733 Alliance "Enables U4 snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4)." FBgn0052177 FlyBase Gene Snapshot Nedd4 family interacting protein (Ndfip) encodes a protein that interacts with the ubiquitin ligases encoded by Nedd4 and Su(dx) and regulates Notch signaling. FBgn0036703 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in antennal mechanosensory and motor center B1 projection neurons and larval central brain. FBgn0015550 UniProtKB May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN. (UniProtKB:O16867) FBgn0040793 Alliance "Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm." FBgn0036726 FlyBase Gene Snapshot QIL1 (QIL1) encodes a subunit of the mitochondrial contact site and cristae organizing system (MICOS) complex. It is required for MICOS stability regulating mitochondrial cristae architecture. FBgn0036727 Alliance "Enables pH-gated chloride channel activity. Involved in several processes, including glycinergic synaptic transmission; negative regulation of neuronal action potential; and transepithelial chloride transport. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including adult central brain; adult gut; epithelial tube; gut section; and salivary gland." FBgn0036728 Alliance "Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 4. Orthologous to human UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII)." FBgn0036730 FlyBase Gene Snapshot quijote (qjt) encodes a SUMO E3 ligase and a highly conserved subunit of the Smc5/6 complex. It is enriched in heterochromatin and recruited to heterochromatic double-strand break repair sites. FBgn0036723 Alliance Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in spermatozoon. FBgn0052174 UniProtKB Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. (UniProtKB:Q9VVG6) FBgn0042641 UniProtKB Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen. (UniProtKB:Q95YI5) FBgn0053052 UniProtKB "Required for centriole duplication likely through its interaction with Sas-6 (PubMed:29892014, PubMed:33704067). During embryogenesis, maternally provided protein is required for centrosome duplication and nuclear division cycles of the syncytial embryos (PubMed:29892014). In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination (PubMed:29892014). In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi (PubMed:29892014). (UniProtKB:Q8IQQ4)" FBgn0053051 Alliance Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of RNA polymerase III complex. Orthologous to several human genes including POLR3GL (RNA polymerase III subunit GL). FBgn0027660 FlyBase Gene Snapshot bloated tubules (blot) encodes a member of the sodium- and chloride-dependent neurotransmitter symporter family. It is required for cortical actin organisation and contributes to embryonic cellularization and renal tubule development in larvae. FBgn0036716 Alliance Predicted to enable actin binding activity and phospholipid binding activity. Predicted to be involved in cell projection assembly and membrane organization. Predicted to be active in actin cytoskeleton and cytoplasmic side of plasma membrane. FBgn0036715 FlyBase Gene Snapshot Cadherin 74A (Cad74A) encodes a non-classical cadherin involved in cell-cell adhesion. FBgn0036712 Alliance "Predicted to enable calcium channel activity. Involved in cellular response to cold and detection of temperature stimulus involved in thermoception. Predicted to be active in membrane. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; and dorsal ectoderm anlage. Orthologous to human PKD1L2 (polycystin 1 like 2 (gene/pseudogene)); PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting); and PKDREJ (polycystin family receptor for egg jelly)." FBgn0052173 Alliance Predicted to enable CCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036710 Alliance Predicted to be active in membrane. Is expressed in adult head. Orthologous to human TMEM209 (transmembrane protein 209). FBgn0036709 FlyBase Gene Snapshot Odorant receptor 74a (Or74a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0036706 Alliance "Predicted to enable oxidoreductase activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Is expressed in adult head and spermatozoon." FBgn0036702 Alliance "Predicted to enable metalloendopeptidase activity. Involved in mitochondrial protein processing. Part of m-AAA complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)." FBgn0052170 Alliance Is expressed in embryonic/larval garland cell and embryonic/larval posterior spiracle. FBgn0010352 Alliance "Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in intracellular amino acid homeostasis and tricarboxylic acid cycle. Located in Z disc and mitochondrion. Is expressed in several structures, including adult head; adult heart; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Used to study Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Orthologous to several human genes including OGDH (oxoglutarate dehydrogenase)." FBgn0036686 Alliance "Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of 90S preribosome. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor)." FBgn0036688 Alliance Predicted to enable integrin binding activity. Involved in cardiac muscle tissue development. Predicted to be active in cell-substrate junction. Human ortholog(s) of this gene implicated in Kindler syndrome; leukocyte adhesion deficiency 1; leukocyte adhesion deficiency 3; telangiectasis; and vesiculobullous skin disease. Orthologous to several human genes including FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2). FBgn0036691 UniProtKB Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondria (By similarity). (UniProtKB:Q8T3L6) FBgn0036695 FlyBase Gene Snapshot "PAPS transporter 2 (Papst2) encodes the second transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and localizes in the cis-cisterna of the Golgi and the ER. It transfers PAPS from cytosol into the lumen of Golgi and ER. The product of Papst2 contributes to the sulfation of glycans and proteins, and is suggested to regulate several signaling pathways (Hh, Dpp, Wingless) mediated by glycosaminoglycans in development." FBgn0036697 FlyBase Gene Snapshot rogdi (rogdi) encodes a protein that plays a role in promoting sleep by controlling GABA transmission in GABA neurons. FBgn0036698 Alliance "Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid delta-isomerase activity. Predicted to be involved in steroid biosynthetic process. Is expressed in several structures, including adult head; clypeo-labral primordium; embryonic dorsal epidermis; embryonic epipharynx; and embryonic head epidermis. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 1; hypertension; hypospadias; and intrahepatic cholestasis. Orthologous to several human genes including HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)." FBgn0036696 Alliance "Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in rRNA processing and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit)." FBgn0036690 FlyBase Gene Snapshot Insulin-like peptide 8 (Ilp8) encodes a divergent member of the insulin/IGF/relaxin-like family that acts through the relaxin receptor encoded by Lgr3. It coordinates growth status of tissues with developmental timing. FBgn0011293 Alliance Predicted to be located in extracellular region. Is expressed in coeloconic sensillum of antennal segment 3; sacculus; and third segment of antenna. FBgn0036687 Alliance Predicted to be involved in intraciliary transport. Located in axoneme. Is expressed in adult head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 5. Orthologous to several human genes including LCA5L (lebercilin LCA5 like). FBgn0036684 Alliance "Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1) and FNIP2 (folliculin interacting protein 2)." FBgn0036679 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. FBgn0036678 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic head epidermis; embryonic/larval posterior spiracle; primary segmental tracheal branch primordium; and primary tracheal branch." FBgn0028693 Alliance "Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human PSMD8 (proteasome 26S subunit, non-ATPase 8)." FBgn0052163 Alliance Orthologous to human NATD1 (N-acetyltransferase domain containing 1). FBgn0042178 Alliance Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in organism and testis. Orthologous to human IPO4 (importin 4). FBgn0042177 Alliance Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; organism; ovary; and spermatozoon. Orthologous to human IPO4 (importin 4). FBgn0025558 Alliance Predicted to be located in membrane. Is expressed in organism. Orthologous to human MANBAL (mannosidase beta like). FBgn0041721 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12 snRNP." FBgn0036652 Alliance Predicted to be involved in cytoplasmic microtubule organization and non-motile cilium assembly. Predicted to be active in centriolar satellite. Is expressed in adult head. Orthologous to human CCDC13 (coiled-coil domain containing 13). FBgn0036654 FlyBase Gene Snapshot CG9692 is a gene of unknown function mainly expressed in the male accessory gland and testis. FBgn0000414 FlyBase Gene Snapshot "Disabled (Dab) encodes an adaptor protein that is a core component of the Abl tyrosine kinase signaling pathway. It associates with transmembrane receptors including those encoded by N and Appl. It is involved in axon patterning, embryo morphogenesis and trafficking in endocytosis, exocytosis and Golgi organization." FBgn0043577 FlyBase Gene Snapshot "Peptidoglycan recognition protein SB2 (PGRP-SB2) encodes a secreted peptidoglycan recognition protein (PGRP) with amidase activity against DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It is strongly induced upon bacterial infection by the immune deficiency pathway, suggesting a role as an immune effector." FBgn0036659 Alliance Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in embryonic proventriculus and gastric caecum. Human ortholog(s) of this gene implicated in congenital lactase deficiency; coronary artery disease; intracranial embolism; and spondylosis. Orthologous to several human genes including LCTL (lactase like). FBgn0004108 UniProtKB May mediate or modulate cell adhesion between embryonic cells during development. (UniProtKB:P23654) FBgn0036661 Alliance "Predicted to enable mRNA 3'-UTR binding activity. Involved in dendrite morphogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and germline cell. Orthologous to human CARHSP1 (calcium regulated heat stable protein 1) and CSDC2 (cold shock domain containing C2)." FBgn0036662 Alliance Predicted to enable acetyl-CoA transmembrane transporter activity. Predicted to be located in membrane. Is expressed in adult head; embryonic proventriculus; embryonic/larval salivary gland; embryonic/larval salivary gland body; and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 42. Orthologous to human SLC33A1 (solute carrier family 33 member 1). FBgn0021768 FlyBase Gene Snapshot nudC (nudC) encodes a component of a specialized dynein complex involved in nucleus localization and positive regulation of dendrite morphogenesis. FBgn0036666 FlyBase Gene Snapshot "Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles." FBgn0036668 Alliance Predicted to enable RNA binding activity. Involved in defense response to virus. Predicted to be part of TRAMP complex. Orthologous to human ZCCHC7 (zinc finger CCHC-type containing 7). FBgn0003410 UniProtKB "E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk) (PubMed:11526076, PubMed:12215542, PubMed:18160715, PubMed:9267026, PubMed:9267027). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:12215542). Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons (PubMed:11526076, PubMed:12215542, PubMed:9267026, PubMed:9267027). Also involved in external sensory organ development (PubMed:11526076). (UniProtKB:P21461)" FBgn0036670 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in embryonic/larval central nervous system. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0036671 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in positive regulation of ubiquitin-dependent protein catabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22). FBgn0003250 UniProtKB "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (UniProtKB:P08255)" FBgn0036667 UniProtKB "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). In addition may regulates nuclear envelope (NE) architecture and nuclear positioning through the linker of nucleoskeleton and cytoskeleton (LINC)-dependent and -independent mechanisms (PubMed:28716842). (UniProtKB:Q9VVA8)" FBgn0036663 Alliance Predicted to enable glutamate synthase (NADH) activity. Predicted to be involved in ammonia assimilation cycle and glutamate biosynthetic process. Is expressed in adult head and spermatozoon. FBgn0025582 FlyBase Gene Snapshot "eukaryotic translation initiation factor 3 subunit e (eIF3e) encodes a component of the translation initiation complex and is a positive regulator of cullin neddylation, which is required for Cullin-ring ubiquitin ligase activity. It also regulates spindle assembly, microtubule dynamics and mitotic progression." FBgn0004556 UniProtKB ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. (UniProtKB:P26802) FBgn0043578 FlyBase Gene Snapshot "Peptidoglycan recognition protein SB1 (PGRP-SB1) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It is strongly induced upon bacterial infection by the immune deficiency pathway, suggesting a role as an immune effector." FBgn0036656 Alliance Is expressed in adult head. FBgn0063485 FlyBase Gene Snapshot "Lasp (Lasp) encodes a member of the nebulin family. It plays subtle roles in modulating the actin cytoskeleton in ovaries, testes, and muscles, by serving as a scaffold protein binding multiple partners, especially actin and myosin. In indirect flight muscles, it contributes to I-band and A-band architecture." FBgn0040512 Alliance "Involved in regulation of lipid storage. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including embryonic epidermis; embryonic proventriculus; embryonic/larval salivary gland; presumptive embryonic salivary gland; and salivary gland body primordium. Orthologous to several human genes including COPZ1 (COPI coat complex subunit zeta 1)." FBgn0010223 FlyBase Gene Snapshot G protein alpha f subunit (Galphaf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function. FBgn0000017 FlyBase Gene Snapshot Abl tyrosine kinase (Abl) encodes a non-receptor tyrosine kinase best known for its ortholog's role in human leukemia. It phosphorylates cell adhesion and cytoskeletal proteins and acts as a scaffold in a signaling complex to regulate both epithelial and nervous system morphogenesis. FBgn0017572 FlyBase Gene Snapshot Mo25 (Mo25) encodes a protein involved in neuroblast asymmetric cell divisions via localization of the product of mira. It physically interacts with the kinase encoded by Lkb1. FBgn0004465 Alliance "Predicted to enable prostaglandin-E synthase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; ganglia; gut section; and mesoderm. Orthologous to human PTGES2 (prostaglandin E synthase 2)." FBgn0002284 UniProtKB "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:P40304)" FBgn0036648 Alliance Predicted to enable ADP-ribose diphosphatase activity. Is expressed in organism. Orthologous to human NUDT9 (nudix hydrolase 9). FBgn0027500 FlyBase Gene Snapshot "spindle defective 2 (spd-2) encodes a centriole and centrosome protein that is primarily involved in centrosome assembly. Together with the product of cnn, it helps to assemble a ""scaffold"" around the mother centriole that can recruit other centrosomal proteins to the centrosome during mitosis." FBgn0036643 Alliance Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; synaptic vesicle docking; and vesicle fusion. Predicted to be located in plasma membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system. Is expressed in adult head. Orthologous to human STX8 (syntaxin 8). FBgn0042201 Alliance Is expressed in adult head and embryonic/larval central nervous system. FBgn0053061 Alliance Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in sarcoplasmic reticulum. Is expressed in eye. FBgn0053060 Alliance Predicted to be part of Set1C/COMPASS complex. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). FBgn0040074 Alliance A structural constituent of eye lens. Located in extracellular space. Is expressed in adult head; cone cell; cornea; organism; and primary pigment cell. FBgn0036612 Alliance Predicted to be involved in proteolysis. FBgn0052357 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036617 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0036618 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0036620 Alliance Predicted to enable alcohol dehydrogenase (NAD+) activity. Predicted to be involved in alcohol metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). FBgn0042137 Alliance Predicted to enable alcohol dehydrogenase (NAD+) activity. Predicted to be involved in alcohol metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). FBgn0036624 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of PcG protein complex. Is expressed in adult head." FBgn0036627 FlyBase Gene Snapshot Gag-related (Gagr) encodes a transmembrane protein with unknown function. It has sequence similarity with Gag proteins of the gypsy group of retrotransposons (errantiviruses). Gagr gene expression is increased in response to the gypsy retrovirus and to Bacillus cereus. FBgn0028399 FlyBase Gene Snapshot TMS1 (TMS1) encodes a putative L-serine transmembrane transporter. FBgn0053158 Alliance "Predicted to enable GTPase activity and ribosome binding activity. Predicted to be involved in cytosolic ribosome assembly. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; central brain primordium; embryonic ventral epidermis; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome. Orthologous to human EFL1 (elongation factor like GTPase 1)." FBgn0003515 UniProtKB "ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters and metabolic intermediates (PubMed:18931318, PubMed:33820991, PubMed:812484). In the eye and probably in association with w/white, required for the transport of the eye brown pigment precursors, kynurenine and probably tryptophan, into pigment cell granules (PubMed:10407069, PubMed:812484). In Malpighian tubules and pupal eyes, involved in kynurenine transport (PubMed:812484). Probably in association with w/white, plays a role in zinc storage granule biogenesis in Malpighian tubule principal epithelial cells (PubMed:29367274). (UniProtKB:P45843)" FBgn0036641 FlyBase Gene Snapshot "survival motor neuron (Smn) encodes the eponymous member of the SMN complex, which functions as an assembly chaperone for Sm-class small nuclear ribonucleoproteins. The SMN complex contains three other 'Gemin' proteins encoded by Gem2, Gem3 and rig. Smn is essential for viability but higher levels of the protein are required for proper neuromuscular development and function." FBgn0026061 FlyBase Gene Snapshot "Multiple inositol polyphosphate phosphatase 1 (Mipp1) encodes a highly conserved extracellular enzyme that removes phosphates from inositol polyphosphates (IP6, IP5 and IP4) to form IP3. The Mipp1 product functions extracellularly to promote filopodia formation. Its enzymatic activity and localization are both key during tracheal cell migration." FBgn0036638 Alliance Is expressed in clypeo-labral primordium; foregut primordium; organism; and ventral epidermis primordium. FBgn0004569 UniProtKB "Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi). (UniProtKB:Q00805)" FBgn0027080 Alliance Enables tyrosine-tRNA ligase activity. Predicted to be involved in tyrosyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; and organism. Used to study Charcot-Marie-Tooth disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). FBgn0036629 Alliance "Predicted to enable glutamate-tRNA ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial)." FBgn0036623 Alliance "Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval corpus cardiacum; and embryonic/larval midgut. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4)." FBgn0036622 Alliance "Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be active in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4)." FBgn0036621 Alliance "Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytoplasmic stress granule. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval salivary gland. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1) and RC3H2 (ring finger and CCCH-type domains 2)." FBgn0036619 Alliance A structural constituent of eye lens. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix and extracellular space. Predicted to be active in extracellular matrix. Is expressed in adult head; eye; photoreceptor neurons; and sensory organ cell. FBgn0011693 FlyBase Gene Snapshot Photoreceptor dehydrogenase (Pdh) encodes a retinal pigment cell dehydrogenase involved in retinol metabolism. FBgn0036614 Alliance Enables small GTPase binding activity. Predicted to be involved in vesicle cytoskeletal trafficking. Located in trans-Golgi network. Orthologous to human CCDC186 (coiled-coil domain containing 186). FBgn0036600 Alliance Is expressed in embryonic antennal sense organ; embryonic head epidermis; embryonic head sensory system; and labral sensory complex. FBgn0044028 FlyBase Gene Snapshot Notum (Notum) encodes an enzyme that cleaves glycophosphatidylinositol anchors. It acts via the product of dlp to influence the range and activity of secreted signaling proteins that interact with proteoglycans in the imaginal discs. FBgn0036560 Alliance Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Orthologous to human PLCXD1 (phosphatidylinositol specific phospholipase C X domain containing 1). FBgn0005536 FlyBase Gene Snapshot Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. FBgn0036563 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036566 FlyBase Gene Snapshot Chloride channel-c (ClC-c) encodes an intracellular chloride transporter that is involved in endosomal lumen acidification. FBgn0036568 Alliance "Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in determination of adult lifespan; regulation of proton transport; and spermatid differentiation. Predicted to be part of mitochondrial proton-transporting ATP synthase, catalytic core. Is expressed in adult head; organism; and spermatozoon." FBgn0036569 Alliance "Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)." FBgn0010280 FlyBase Gene Snapshot TBP-associated factor 4 (Taf4) encodes a protein that forms part of the multisubunit basal transcription factor TFIIID. It is important in maintaining TFIIID stability for activator dependent transcription. It forms a histone-like pair with the product of Taf12. FBgn0036571 UniProtKB "Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458). (UniProtKB:Q9VUY8)" FBgn0011016 Alliance Located in endomembrane system. Is expressed in adult head; adult heart; and organism. Orthologous to human SSR2 (signal sequence receptor subunit 2). FBgn0052153 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036579 Alliance "Predicted to enable protein-disulfide reductase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including CNS glial cell; adult head; central brain primordium; ganglia; and photoreceptor. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3)." FBgn0036581 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9GYU7)" FBgn0036585 Alliance Is expressed in adult head. FBgn0036590 Alliance Is expressed in adult head and organism. FBgn0036597 Alliance Is expressed in adult head. FBgn0036594 Alliance Is expressed in adult head and adult heart. FBgn0036593 Alliance Is expressed in adult head. FBgn0036592 Alliance "Located in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval posterior spiracle; and embryonic/larval tracheal section." FBgn0036587 Alliance Is expressed in adult head. FBgn0036580 Alliance "Predicted to enable DNA binding activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; trunk mesoderm; and visceral muscle primordium. Orthologous to human PDCD5 (programmed cell death 5)." FBgn0052152 Alliance Predicted to enable histone methyltransferase activity and protein-arginine N-methyltransferase activity. Predicted to be involved in chromatin remodeling. FBgn0036575 Alliance Predicted to enable heme binding activity. Predicted to be active in intracellular membrane-bounded organelle and membrane. FBgn0003076 FlyBase Gene Snapshot "Phosphoglucomutase 1 (Pgm1) encodes an enzyme that catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. It is involved in various glucose metabolic processes including glycogen metabolism, glycolysis and galactose metabolism." FBgn0036570 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q95TS5)" FBgn0036567 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in intraciliary transport. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. FBgn0036565 Alliance "Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic central brain neurons; ganglia; and head epidermis primordium. Orthologous to human MOXD1 (monooxygenase DBH like 1)." FBgn0036531 Alliance Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be part of transcription elongation factor complex. Orthologous to human ELOF1 (elongation factor 1). FBgn0015025 Alliance Enables protein kinase binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism. FBgn0040230 UniProtKB Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth. (UniProtKB:Q9VUU5) FBgn0036536 Alliance Predicted to be located in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type Ib. Orthologous to human CDIN1 (CDAN1 interacting nuclease 1). FBgn0036545 Alliance Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Is expressed in adult head; foregut anlage in statu nascendi; and organism. Orthologous to human PLA2G12A (phospholipase A2 group XIIA) and PLA2G12B (phospholipase A2 group XIIB). FBgn0036547 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic/larval muscle cell; and gut section." FBgn0036549 Alliance Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). FBgn0036550 Alliance Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. FBgn0036551 Alliance Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. Is expressed in amnioserosa; embryonic Malpighian tubule; and yolk nucleus. FBgn0036552 Alliance Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. FBgn0036553 Alliance Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. Is expressed in embryonic Malpighian tubule and embryonic proventriculus. FBgn0000115 FlyBase Gene Snapshot ADP ribosylation factor-like 1 (Arl1) encodes an Arf GTPase important for secretory granule maturation and for preventing early degradation of these granules. FBgn0036557 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human MRPS31 (mitochondrial ribosomal protein S31)." FBgn0036556 UniProtKB Prion-like membrane-associated phosphatase (PubMed:31491385). Phosphatase activity depends on amyloid-like assembly at the membrane (PubMed:31491385). Might have a role in establishment of segment polarity in embryos (PubMed:31491385). (UniProtKB:M9PFN0) FBgn0000212 FlyBase Gene Snapshot "brahma (brm) encodes the ATPase subunit of the Brahma chromatin-remodeling complex, which is involved in transcription regulation. It regulates Egfr signalling, stem cell proliferation, and innate immune response. It contributes to multiple processes including neurogenesis, muscle development, phagocytosis, His3-K27 acetylation and leg and wing morphogenesis." FBgn0000489 UniProtKB Does not have an essential role in development. (UniProtKB:P16912) FBgn0052150 FlyBase Gene Snapshot "meru (meru) encodes a scaffold protein belonging to the N-terminal RASSF (Ras-association domain family) protein family. It is expressed in sensory organ precursor cells, where it promotes the planar polarization of the polarity protein encoded by baz." FBgn0036538 Alliance Located in cytoplasm. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human ZNF706 (zinc finger protein 706). FBgn0036537 Alliance Is expressed in adult head. Orthologous to human ZNF706 (zinc finger protein 706). FBgn0036499 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Is expressed in organism and testis. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B). FBgn0036500 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in adult head and organism. Orthologous to human DCAF13 (DDB1 and CUL4 associated factor 13)." FBgn0036501 Alliance Predicted to enable sugar transmembrane transporter activity. Predicted to be involved in carbohydrate transmembrane transport. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in membrane. Is expressed in adult head; extraembryonic structure; ganglia; and yolk nucleus. FBgn0000565 FlyBase Gene Snapshot Ecdysone-induced protein 28/29kD (Eip71CD) encodes a methionine-S-sulfoxide reductase involved in the response to oxidative stress. It contributes to determination of adult lifespan and neuron projection. FBgn0036504 Alliance Predicted to be active in extracellular region. FBgn0004396 FlyBase Gene Snapshot Cyclic-AMP response element binding protein A (CrebA) encodes a leucine-zipper transcription factor that upregulates genes encoding protein components of the canonical secretory pathway and tissue-specific genes in the salivary gland and epidermis. FBgn0036510 UniProtKB Promotes neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes and thus regulates SCF-type complex activity (PubMed:26792857). Function promotes cell proliferation (PubMed:26792857). (UniProtKB:Q9VUQ8) FBgn0036512 UniProtKB "Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. (UniProtKB:Q9VUR0)" FBgn0036514 Alliance Predicted to be involved in rRNA processing. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human UTP14A (UTP14A small subunit processome component) and UTP14C (UTP14C small subunit processome component). FBgn0036515 FlyBase Gene Snapshot "aaRS-interacting multifunctional protein 2 (AIMP2) is predicted to encode one of 3 non-enzymatic factors that combine with eight aminoacyl-tRNA synthetases to form a 'multi-synthetase complex' (MSC). The functional significance of the MSC is unclear, but the non-enzymatic factors are thought to be responsive to diverse signal transduction pathways." FBgn0036518 FlyBase Gene Snapshot Rho GTPase activating protein at 71E (RhoGAP71E) encodes a Rho GTPase activating protein that is involved in the regulation of actin dynamics during epithelial morphogenesis. FBgn0036522 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ganglia; gonad; and ventral nerve cord primordium." FBgn0004589 Alliance Predicted to be involved in defense response to bacterium. Predicted to be located in extracellular region. FBgn0004591 Alliance Predicted to be involved in defense response to bacterium. Predicted to be located in extracellular region. Is expressed in adult heart. FBgn0004594 Alliance Predicted to be involved in defense response to bacterium. Predicted to be located in extracellular region. FBgn0014849 Alliance Involved in metamorphosis. Predicted to be located in extracellular region. FBgn0014851 Alliance Involved in metamorphosis. Predicted to be located in extracellular region. FBgn0036527 UniProtKB Probable inactive glycosyltransferase. (UniProtKB:Q8IA44) FBgn0036529 UniProtKB "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers both EA2 and the diglycosylated Muc5AC-3/13 as substrates, albeit at very low levels fro Muc5AC-3/13. (UniProtKB:Q9VUT6)" FBgn0010105 FlyBase Gene Snapshot commissureless (comm) product regulates the cell surface localization of Robo axon guidance receptors by intercepting them in the ER/Golgi during exocytosis or removing them from the surface by endocytosis. comm is required for formation of the CNS axon scaffold and synaptogenesis. FBgn0041160 UniProtKB Essential for nerve cord development. Functions downstream of fra to control axon guidance across the central nervous system (CNS) midline. (UniProtKB:Q9VUT8) FBgn0036528 UniProtKB Probable inactive glycosyltransferase. (UniProtKB:Q8IA41) FBgn0014850 Alliance Involved in metamorphosis. Predicted to be located in extracellular region. FBgn0014848 Alliance Involved in metamorphosis. Predicted to be located in extracellular region. FBgn0004593 Alliance Predicted to be involved in defense response to bacterium. Predicted to be located in extracellular region. FBgn0004592 FlyBase Gene Snapshot "Ecdysone-induced gene 71Ee (Eig71Ee) encodes a protein of unknown function. It is expressed in larvae in both salivary glue and the hemolymph clot, where it is a substrate of the product of Tg." FBgn0004590 Alliance Involved in metamorphosis. Predicted to be located in extracellular region. FBgn0004588 Alliance Involved in metamorphosis. Predicted to be located in extracellular region. FBgn0036519 UniProtKB "Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. (UniProtKB:Q9VUR7)" FBgn0036516 Alliance "Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in central brain primordium; embryonic brain; organism; and ventral nerve cord primordium. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme) and UBE2R2 (ubiquitin conjugating enzyme E2 R2)." FBgn0036509 Alliance Predicted to be active in plasma membrane. Is expressed in adult head and organism. Orthologous to human ITFG1 (integrin alpha FG-GAP repeat containing 1). FBgn0036505 Alliance Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in protein stabilization. Is expressed in organism. Orthologous to human BAG2 (BAG cochaperone 2). FBgn0004228 UniProtKB Involved in morphogenesis and development. (UniProtKB:P23487) FBgn0036503 Alliance Is expressed in organism. FBgn0036502 Alliance "Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and visceral muscle primordium. Orthologous to human MCRIP2 (MAPK regulated corepressor interacting protein 2)." FBgn0026738 Alliance Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). FBgn0040805 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). FBgn0029114 FlyBase Gene Snapshot "Tollo (Tollo) encodes a member of the Toll-like receptor family. It contributes to the innate immune response, regulation of glucose metabolism and protein glycosylation, as well as peripheral nervous system development. Genetic interaction with 18w and Toll-6 suggests a Tollo role in convergent extension during early embryogenesis." FBgn0036491 Alliance Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Orthologous to human BEST2 (bestrophin 2) and BEST4 (bestrophin 4). FBgn0036494 FlyBase Gene Snapshot Toll-6 (Toll-6) encodes a member of the Toll-like receptor family. It has neurotrophin receptor activity and contributes to dendrite guidance. Genetic interaction with 18w and Tollo suggests a Toll-6 role in convergent extension during early embryogenesis. FBgn0036495 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0036497 UniProtKB GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. (UniProtKB:Q9VUN3) FBgn0036496 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be part of chromatin. Predicted to be active in nucleoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). FBgn0036492 FlyBase Gene Snapshot "Bestrophin 3 (Best3) encodes a paralog of the product of Best1, a Ca-activated Cl channel. A C-terminal domain inhibits the Cl channel function so that the product of Best3 does not produce current at physiological transmembrane voltages." FBgn0026320 FlyBase Gene Snapshot Twin of m4 (Tom) is a member of the Bearded gene family that encodes a regulator of the Notch signaling pathway. FBgn0000216 FlyBase Gene Snapshot "Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification." FBgn0040296 Alliance "Enables ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of Notch signaling pathway. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium." FBgn0036459 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0036460 Alliance "Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human AAMP (angio associated migratory cell protein)." FBgn0002778 FlyBase Gene Snapshot minidiscs (mnd) encodes the putative amino acid/polyamine transporter involved in leucine import. It is expressed in the larval fat body and is required for the differentiation of the wing imaginal disc cells. FBgn0036461 FlyBase Gene Snapshot Zinc/iron regulated transporter-related protein 71B (Zip71B) encodes a protein involved in zinc detoxification and zinc transmembrane import. FBgn0023174 FlyBase Gene Snapshot "Proteasome beta2 subunit (Prosbeta2) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus." FBgn0036470 FlyBase Gene Snapshot Enhancer of Acetyltransferase Chameau (EAChm) encodes a protein that regulates gene transcription in embryos by enhancing the activity of the histone H3 acetyltransferase encoded by chm. FBgn0027088 FlyBase Gene Snapshot Glycyl-tRNA synthetase (GlyRS) encodes a protein involved in dendrite morphogenesis and larval lymph gland hemopoiesis. FBgn0036479 Alliance Is expressed in adult head. Orthologous to human MSS51 (MSS51 mitochondrial translational activator). FBgn0036480 FlyBase Gene Snapshot Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. FBgn0052847 Alliance Predicted to enable ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding activity; and zinc ion binding activity. Predicted to be involved in ERAD pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human RNF185 (ring finger protein 185) and RNF5 (ring finger protein 5). FBgn0036484 FlyBase Gene Snapshot Peroxin 3 (Pex3) encodes a peroxisomal membrane protein (PMP) involved in de novo peroxisome biogenesis from the endoplasmic reticulum and PMP import from the cytosol. It also facilitates the insertion of proteins into the membrane of mature peroxisomes via its interaction with the PMP chaperone encoded by Pex19. FBgn0036485 FlyBase Gene Snapshot "alpha1,3-fucosyltransferase A (FucTA) encodes a Golgi fucosyltransferase that transfers fucose in alpha1,3-linkage to core N-acetylglucosamine residues of N-linked oligosaccharides. It is required for the synthesis of the anti-horseradish peroxidase epitope." FBgn0036487 FlyBase Gene Snapshot Pre-mRNA processing factor 31 (Prp31) encodes a splicing factor associated with U4/U6.U5 tri-snRNP. It plays important roles in pre-mRNA splicing and other steps of RNA processing. Prp31 is essential for photoreceptor development. FBgn0036488 Alliance Predicted to enable monoatomic cation transmembrane transporter activity. Involved in regulation of autophagy of mitochondrion. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and adult heart. Orthologous to human ROMO1 (reactive oxygen species modulator 1). FBgn0036490 Alliance Enables peroxiredoxin activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and removal of superoxide radicals. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). FBgn0036489 Alliance "Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human ERGIC3 (ERGIC and golgi 3)." FBgn0036486 FlyBase Gene Snapshot Msh6 (Msh6) encodes a heterodimer with the product of spel1 to detect base-base mismatches and small insertion/deletion loops. It then recruits the rest of the mismatch repair machinery. FBgn0047178 Alliance Predicted to enable pyroglutamyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. Is expressed in organism. Orthologous to several human genes including PGPEP1 (pyroglutamyl-peptidase I). FBgn0036483 Alliance Located in cytoplasm. Is expressed in organism. FBgn0036481 Alliance "Is expressed in several structures, including embryonic esophagus; embryonic head epidermis; embryonic large intestine; primary segmental tracheal branch primordium; and primary tracheal branch." FBgn0036476 FlyBase Gene Snapshot stepping stone (sstn) encodes an adaptor protein that forms a complex with the plasma membrane encoded by step through direct coil-coil domain interactions. It functions with the product of step to antagonize actomyosin networks during cleavage of the Drosophila embryo. FBgn0036474 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:Q9VUK5)" FBgn0025776 FlyBase Gene Snapshot intermediate neuroblasts defective (ind) encodes a transcription factor involved in the development of the central nervous system. FBgn0036465 Alliance "Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, lid subcomplex. Predicted to be active in nucleus. Orthologous to human PSMD8 (proteasome 26S subunit, non-ATPase 8)." FBgn0036463 Alliance Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization. Predicted to be active in plasma membrane. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). FBgn0036462 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39)." FBgn0040487 Alliance "Enables ubiquitin protein ligase binding activity. Involved in several processes, including defense response to bacterium; negative regulation of Notch signaling pathway; and sensory organ precursor cell fate determination." FBgn0003388 FlyBase Gene Snapshot "shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation." FBgn0036433 Alliance "Predicted to be involved in septate junction assembly. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; dorsal epidermis primordium; embryonic anal pad; embryonic dorsal epidermis; and gut section." FBgn0041604 FlyBase Gene Snapshot dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg. FBgn0011928 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036437 Alliance "Predicted to enable dynein intermediate chain binding activity and protein-folding chaperone binding activity. Involved in axonemal dynein complex assembly. Part of R2TP complex. Is active in cytosol. Is expressed in several structures, including embryonic head sensory system; embryonic labial sensory complex; embryonic maxillary sensory complex; sensory nervous system primordium; and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 36. Orthologous to human DNAAF6 (dynein axonemal assembly factor 6)." FBgn0036438 FlyBase Gene Snapshot "goddard (gdrd) is a newly evolved gene that encodes a predicted disordered protein with no homology to other protein families. It is implicated in male reproduction, as males with reduced gdrd expression fail to produce sperm." FBgn0036442 Alliance Predicted to enable protein-disulfide reductase activity. Predicted to be active in cytoplasm. Orthologous to human TXN (thioredoxin). FBgn0036446 Alliance "Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult head. Orthologous to several human genes including MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A) and MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B)." FBgn0036450 Alliance Predicted to enable RNA binding activity. Predicted to be involved in mRNA processing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in adult head; embryonic brain; and organism. Orthologous to human TDRD3 (tudor domain containing 3). FBgn0036451 Alliance Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in P granule and cytosol. Is expressed in adult head. Orthologous to human HELZ (helicase with zinc finger). FBgn0036454 Alliance Located in nucleus. Is expressed in adult brain cell body rind; adult head; and spermatozoon. FBgn0001120 FlyBase Gene Snapshot "giant nuclei (gnu) encodes a regulatory subunit of the PNG kinase complex, which regulates the levels of the protein encoded by CycB. Members of this complex are required maternally for the normal nuclear divisions of the syncytial embryo." FBgn0029148 UniProtKB "Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (UniProtKB:Q9V3U2)" FBgn0036449 FlyBase Gene Snapshot "brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis." FBgn0036448 FlyBase Gene Snapshot myopic (mop) encodes an endocytic protein that is required for normal Egfr signaling and for the progression of the product of Egfr through the endocytic pathway. It also controls the endosomal localization and signaling activity of the product of yki. FBgn0036447 Alliance "Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4C (MGAT4 family member C)." FBgn0053260 Alliance Predicted to enable tRNA-intron endonuclease activity. Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). FBgn0036440 Alliance Predicted to enable acetyl-CoA carboxylase activity. Predicted to be involved in fatty acid biosynthetic process and malonyl-CoA biosynthetic process. Is expressed in spermatozoon. FBgn0036439 Alliance Predicted to enable adenosine kinase activity. Predicted to be involved in purine ribonucleoside salvage. FBgn0036436 Alliance "Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic hindgut; embryonic precursor of adult hindgut; embryonic ventral epidermis; and foregut primordium." FBgn0011927 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036423 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in germline cell; gonad; organism; and primordial germ cell. FBgn0036426 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. FBgn0026409 Alliance "Enables phosphate transmembrane transporter activity. Involved in wing disc dorsal/ventral pattern formation. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human SLC25A3 (solute carrier family 25 member 3)." FBgn0040318 FlyBase Gene Snapshot HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. FBgn0028418 FlyBase Gene Snapshot Leucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons. FBgn0036428 FlyBase Gene Snapshot "Glycogen binding subunit 70E (Gbs-70E) is one of the glycogen binding subunits of protein phosphatase 1 (Pp1) that interacts with all of the known Pp1 catalytic subunits (encoded by Pp1-87B, flw, Pp1alpha-96A, and Pp1-13C). The product of Gbs-70E is involved in the regulation of glycogen metabolism, and plays a role in the egg development." FBgn0036427 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0003459 FlyBase Gene Snapshot stonewall (stwl) encodes a protein that is associated with heterochromatin and modifies levels of trimethylated H3K27 and H3K9. stwl product is required for maintenance of female germline stem cells and for survival of genotoxic stress induced by DNA replication inhibition. FBgn0036422 Alliance Predicted to be located in extracellular space. FBgn0036421 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. FBgn0052141 FlyBase Gene Snapshot "saturn (saturn) is a newly evolved gene that encodes a predicted disordered protein with no homology to other known proteins. Males with reduced saturn expression are near-sterile, showing low sperm production and no sperm storage in mated females." FBgn0036415 Alliance Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in mitochondrion and nucleus. Orthologous to human PPIF (peptidylprolyl isomerase F). FBgn0001085 FlyBase Gene Snapshot frizzled (fz) encodes the founding member of the Fz family of receptors for Wnt ligands. It is part of Wnt signaling and planar cell polarity pathways. FBgn0000411 FlyBase Gene Snapshot "Dichaete (D) encodes an HMG-domain protein and member of the Sox family of transcription factors. Its roles include hindgut development, embryonic segmentation, and nervous system development." FBgn0042630 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; embryonic hypopharynx; gut section; imaginal disc; and supraesophageal ganglion. Orthologous to several human genes including SOX21 (SRY-box transcription factor 21)." FBgn0036411 FlyBase Gene Snapshot Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut. FBgn0000639 Alliance Is expressed in adult head; adult heart; and embryonic/larval hemolymph. FBgn0043550 FlyBase Gene Snapshot Tetraspanin 68C (Tsp68C) encodes a member of the tetraspanin superfamily of integral membrane proteins that are involved in cell adhesion and signal transduction. Its proposed functions include the regulation of Notch signaling and the control of Ras/Raf-mediated proliferation in hemocytes. FBgn0029167 FlyBase Gene Snapshot Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. FBgn0001108 FlyBase Gene Snapshot "Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis." FBgn0052137 Alliance "Involved in chaeta development and protein transport along microtubule. Predicted to be active in cytosol. Is expressed in several structures, including amnioserosa; dorsal pharyngeal muscle cell; embryonic head sensory system; gut section; and sense organ. Orthologous to several human genes including BICDL1 (BICD family like cargo adaptor 1)." FBgn0036389 FlyBase Gene Snapshot "short spindle 2 (ssp2) encodes a microtubule plus-end-tracking protein that binds to the product of Eb1 and the microtubule polymerase encoded by msps. It contributes to dynamic microtubule behaviour, spindle size and kinetochore-microtubule interaction." FBgn0001216 Alliance "Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA2 (heat shock protein family A (Hsp70) member 2)." FBgn0036395 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. Is expressed in organism. FBgn0036398 FlyBase Gene Snapshot upSET (upSET) encodes a Polycomb/Trithorax-type global transcriptional regulator. It is recruited to active and inducible genes where it restricts chromatin accessibility and histone acetylation to promoter regions. upSET loss produces female sterility. FBgn0036402 Alliance Predicted to enable ADP-specific glucokinase activity. Predicted to be involved in glucose metabolic process. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; organism; and spermatozoon. Orthologous to human ADPGK (ADP dependent glucokinase). FBgn0036403 Alliance Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). FBgn0026418 FlyBase Gene Snapshot Heat shock protein 110 (Hsp110) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. FBgn0036405 Alliance "Predicted to enable exonuclease activity. Predicted to be involved in rRNA processing. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to human REXO4 (REX4 homolog, 3'-5' exonuclease)." FBgn0013563 FlyBase Gene Snapshot "Peroxin 1 (Pex1) encodes a member of the family of AAA-ATPases required for peroxisome assembly. Pex1 loss results in disorganization of neurons and glia and embryonic lethality. Larval escapers exhibit developmental delay, poor feeding and uncoordinated locomotion." FBgn0036397 FlyBase Gene Snapshot "Nitrogen permease regulator-like 3 (Nprl3) encodes a component of the highly conserved GAP activity towards rags 1 (GATOR1) complex, which inhibits the product of mTor activity in response to amino acid starvation. The product of Nprl3, as well as the other GATOR1 components encoded by Nprl2 and Iml1, regulates early meiotic progression." FBgn0036396 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. FBgn0025874 Alliance Predicted to enable zinc ion binding activity. Located in cytoplasm; nucleus; and spindle microtubule. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; head mesoderm; organism; and trunk mesoderm. Orthologous to human ZNF254 (zinc finger protein 254); ZNF726 (zinc finger protein 726); and ZNF93 (zinc finger protein 93). FBgn0036386 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human GPATCH1 (G-patch domain containing 1)." FBgn0026376 Alliance Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway and positive regulation of stem cell proliferation. Predicted to be active in plasma membrane. Is expressed in organism. Orthologous to several human genes including RGL1 (ral guanine nucleotide dissociation stimulator like 1). FBgn0036381 Alliance "Predicted to enable ethanolamine-phosphate phospho-lyase activity. Involved in response to nicotine. Is expressed in several structures, including adult head; amnioserosa; amnioserosa primordium; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including ETNPPL (ethanolamine-phosphate phospho-lyase)." FBgn0036380 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0036368 Alliance "Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in several processes, including Golgi organization; negative regulation of cell size; and positive regulation of mitotic cell cycle. Predicted to be active in plasma membrane. Is expressed in adult head." FBgn0036373 FlyBase Gene Snapshot Tondu-domain-containing Growth Inhibitor (Tgi) encodes a protein that interacts with both components of the sd-yki transcriptional complex to inhibit its activity and thus restrict tissue growth. FBgn0036376 FlyBase Gene Snapshot Liprin-beta (Liprin-beta) encodes an adaptor protein that can interact with the product of Liprin-alpha. It is required for normal photoreceptor axon targeting and neuromuscular junction development. FBgn0036377 Alliance Is expressed in dorsal pharyngeal muscle cell and embryonic/larval muscle system. FBgn0036372 FlyBase Gene Snapshot "Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development." FBgn0036369 Alliance Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytosol. Is expressed in organism. Orthologous to several human genes including DUSP22 (dual specificity phosphatase 22). FBgn0036367 Alliance "Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0036366 Alliance Predicted to enable peptidyl-lysine 3-dioxygenase activity. Located in cytoplasm. Is expressed in organism. Used to study alcohol use disorder. Orthologous to human JMJD7 (jumonji domain containing 7). FBgn0052129 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052128 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052126 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052127 Alliance Predicted to enable UUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0023095 FlyBase Gene Snapshot "capricious (caps) encodes a transmembrane receptor with leucine-rich repeats that mediates cell interaction in a homophilic or heterophilic manner. caps product contributes to cellular interaction critical for synapse formation and axon guidance, as well as mediating morphogenesis of multiple tissues, including wings, legs and the tracheal system." FBgn0011844 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003034 FlyBase Gene Snapshot "Sex Peptide (SP) encodes a peptide produced by the male accessory glands and transferred to females during mating. In mated females, it induces post-mating responses including increased egg production, decreased receptivity to mating, changes in juvenile hormone levels, in longevity and in sperm release from storage, and in feeding, digestion, and activity." FBgn0036348 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme. Is expressed in adult head; chordotonal neurons; and spermatogonium. Human ortholog(s) of this gene implicated in normal pressure hydrocephalus and spermatogenic failure 19. Orthologous to human CFAP43 (cilia and flagella associated protein 43). FBgn0036349 Alliance "Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Colocalizes with nucleolus. Is expressed in several structures, including anterior endoderm anlage; foregut anlage; hindgut anlage; mesoderm; and mesoderm anlage." FBgn0001256 Alliance "Predicted to be located in extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic head epidermis; epidermis; and gut section." FBgn0036352 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic head epidermis; embryonic hindgut; embryonic ventral epidermis; and epidermis." FBgn0012010 Alliance Predicted to enable GUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036364 Alliance Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. FBgn0036365 FlyBase Gene Snapshot "combover (cmb) encodes an in vitro substrate of the product of Rok, that physically interacts with the planar cell polarity (PCP) effector encoded by mwh, contributing to PCP during wing hair formation. Independent of PCP, cmb is required for spermiogenesis, during which it interacts with Rsph3." FBgn0036363 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036361 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0012009 Alliance Predicted to enable GUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036359 Alliance Predicted to be involved in cilium assembly. Orthologous to human TTC36 (tetratricopeptide repeat domain 36). FBgn0053263 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0052121 Alliance Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. FBgn0036356 Alliance Predicted to enable GTPase activity. Orthologous to human GPN2 (GPN-loop GTPase 2). FBgn0002573 FlyBase Gene Snapshot senseless (sens) encodes a transcription factor that stimulates expression of proneural gene expression. It regulates differentiation of the peripheral nervous system and the R8 photoreceptor. FBgn0036354 FlyBase Gene Snapshot "Proteome of centrioles 1 (Poc1) encodes a cytoplasmic protein located in the sperm giant centriole and proximal centriole-like structure (PCL), which assists in the elongation of the giant centrioles and recruitment of centriolar proteins to the PCL. It contributes to sperm motility and fertility." FBgn0036353 Alliance "Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; embryonic large intestine; and gut section. Orthologous to human TMEM19 (transmembrane protein 19)." FBgn0036351 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0036321 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). FBgn0036323 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). FBgn0036328 Alliance Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in gluconeogenesis and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head; spermatozoon; and testis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). FBgn0036329 Alliance Predicted to enable monoatomic ion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein). FBgn0036330 UniProtKB RNA-binding protein. Inactive exonuclease. (UniProtKB:Q9VU31) FBgn0036334 Alliance "Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; germline cell; gut section; and visceral mesoderm derivative. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1)." FBgn0036336 Alliance Predicted to enable protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in organism. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). FBgn0036340 FlyBase Gene Snapshot "SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl." FBgn0011284 FlyBase Gene Snapshot Ribosomal protein S4 (RpS4) encodes a structural constituent of ribosomes. FBgn0036341 FlyBase Gene Snapshot Syntaxin 13 (Syx13) encodes a member of the syntaxin family of t-SNAREs that mediate vesicle fusion within cells. It localizes to endosomes and is involved in autophagosome maturation. FBgn0010452 FlyBase Gene Snapshot tartan (trn) encodes a transmembrane leucine-rich repeat protein. It is closely related to caps and genetically interacts with it. Together they regulate embryonic motor axon guidance and innervation of antennal lobe glomeruli by olfactory sensory axons. The product of trn is a substrate for the product of Ptp52F and genetically interacts with it to regulate guidance of SNa motor axons. FBgn0036346 Alliance Predicted to enable acetylpyruvate hydrolase activity. Orthologous to human FAHD2A (fumarylacetoacetate hydrolase domain containing 2A) and FAHD2B (fumarylacetoacetate hydrolase domain containing 2B). FBgn0036345 Alliance "Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be part of mitochondrial proton-transporting ATP synthase, stator stalk." FBgn0036337 Alliance "Predicted to enable adenosine kinase activity. Predicted to be involved in AMP biosynthetic process and purine nucleobase metabolic process. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain; adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle cell. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase)." FBgn0036335 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Is expressed in adult head and adult heart. Orthologous to human MRPL20 (mitochondrial ribosomal protein L20). FBgn0036333 Alliance "Involved in endocytic recycling. Is active in terminal bouton. Is expressed in several structures, including Malpighian tubule primordium; embryonic epipharynx; embryonic/larval midgut primordium; epithelium; and gut section. Orthologous to several human genes including MICALL1 (MICAL like 1)." FBgn0036332 Alliance Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism. FBgn0036327 Alliance Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in gluconeogenesis and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in Nebenkern; adult head; and testis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). FBgn0041622 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:P82985)" FBgn0052117 Alliance Located in nucleoplasm. FBgn0036324 Alliance Predicted to enable SCF ubiquitin ligase complex binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0015904 FlyBase Gene Snapshot "araucan (ara) encodes a homeodomain-containing protein of the TALE subfamily and one of the three components of the Iroquois gene complex. ara product acts as a transcriptional regulator to control territorial and cell fate specification, cell sorting behaviour and pattern formation. It also plays a transcription independent cell-autonomous role in cell proliferation control." FBgn0015919 FlyBase Gene Snapshot "caupolican (caup) encodes a homeodomain-containing protein of the TALE subfamily and one of the three components of the Iroquois gene complex. caup product acts as a transcriptional regulator to control territorial and cell fate specification, cell sorting behaviour and pattern formation. It also plays a transcription independent cell-autonomous role in cell proliferation control." FBgn0014343 FlyBase Gene Snapshot "mirror (mirr) encodes an iroquois homeobox transcription factor involved in dorso-ventral axis formation during oogenesis and eye formation. It also contributes to embryonic segmentation, peripheral nervous system development and growth regulation." FBgn0014007 FlyBase Gene Snapshot "Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons." FBgn0052112 Alliance Orthologous to human ABHD18 (abhydrolase domain containing 18). FBgn0052109 Alliance Human ortholog(s) of this gene implicated in punctate palmoplantar keratoderma type I. Orthologous to human AAGAB (alpha and gamma adaptin binding protein). FBgn0036305 Alliance "Located in nucleoplasm. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; and mesoderm. Orthologous to human ANKRD12 (ankyrin repeat domain 12)." FBgn0052113 FlyBase Gene Snapshot "Vacuolar protein sorting 13D (Vps13D) encodes a ubiquitin-binding protein that is required for autophagy, normal mitochondrial size and mitochondrial clearance. It functions with the Endosomal Sorting Complexes Required for Transport (ESCRT) in a common autophagy pathway." FBgn0052110 Alliance Predicted to enable deSUMOylase activity. Predicted to be involved in protein desumoylation. Predicted to be active in nucleus. Orthologous to several human genes including SENP2 (SUMO specific peptidase 2). FBgn0036318 FlyBase Gene Snapshot WW domain binding protein 2 (Wbp2) encodes a protein that binds to the Hippo pathway component encoded by yki. It has been linked to promotion of tissue growth via the product of yki. FBgn0036319 Alliance Predicted to enable monoamine transmembrane transporter activity and nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human SLC29A4 (solute carrier family 29 member 4). FBgn0036317 Alliance Predicted to enable NADH dehydrogenase activity; mRNA binding activity; and protein disulfide isomerase activity. Predicted to be involved in ultradian rhythm. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including ENOX1 (ecto-NOX disulfide-thiol exchanger 1). FBgn0036316 Alliance "Predicted to enable dehydroascorbic acid transmembrane transporter activity; fructose transmembrane transporter activity; and glucose transmembrane transporter activity. Involved in glucose transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval glial cell; and ganglia. Orthologous to human SLC2A8 (solute carrier family 2 member 8)." FBgn0036314 Alliance Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal complex assembly. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in anterior endoderm; head mesoderm; organism; posterior endoderm; and trunk mesoderm. Orthologous to human SF3A2 (splicing factor 3a subunit 2). FBgn0036310 Alliance Is expressed in spermatozoon. FBgn0036309 Alliance "Predicted to enable several functions, including anion binding activity; clathrin adaptor activity; and clathrin light chain binding activity. Predicted to be involved in actin filament organization; clathrin coat assembly; and endocytosis. Predicted to be active in clathrin-coated vesicle and cortical actin cytoskeleton. Is expressed in adult head. Orthologous to human HIP1 (huntingtin interacting protein 1) and HIP1R (huntingtin interacting protein 1 related)." FBgn0010235 FlyBase Gene Snapshot "Kinesin light chain (Klc) encodes a component of the kinesin motor protein complex, which moves along microtubules to transport cytoplasmic ""cargoes"" such as mRNAs, protein complexes, and organelles." FBgn0052105 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; antennal anlage; ganglia; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7 and nail-patella syndrome. Orthologous to human LMX1A (LIM homeobox transcription factor 1 alpha) and LMX1B (LIM homeobox transcription factor 1 beta)." FBgn0036277 Alliance "Predicted to contribute to RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head. Orthologous to human LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)." FBgn0011279 UniProtKB "Odorant-binding protein required for olfactory behavior and activity of pheromone-sensitive neurons in response to the male-specific pheromone cis-vaccenyl acetate (cVA). Modulates social responsivity differently in males and females, regulating male aggression and female receptivity respectively. (UniProtKB:P54191)" FBgn0036286 UniProtKB May play a role in the trafficking of a subset of G-protein coupled receptors. (UniProtKB:Q9VTX8) FBgn0036291 Alliance Predicted to be involved in lysosome localization. Predicted to be part of BORC complex. Is expressed in organism. Orthologous to human KXD1 (KxDL motif containing 1). FBgn0036300 FlyBase Gene Snapshot "Phosphomannomutase type 2 (Pmm2) encodes a putative enzyme that is predicted to catalyze the conversion of D-mannose 6-phosphate into alpha-D-mannose 1-phosphate. It is involved in the synthesis of GDP-mannose, a precursor for protein N-glycosylation." FBgn0036301 Alliance "Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human KLHDC4 (kelch domain containing 4)." FBgn0036299 FlyBase Gene Snapshot Transferrin 2 (Tsf2) encodes a protein that requires binding with iron for protein function. It is localised at the paracellular septate junctions in epithelial tissues and is required for junction assembly. Tsf2 mutants show overelongated tracheal tubes. FBgn0036298 FlyBase Gene Snapshot "nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling." FBgn0004926 UniProtKB "Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. (UniProtKB:P41375)" FBgn0020388 FlyBase Gene Snapshot Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. FBgn0002466 FlyBase Gene Snapshot sticky (sti) encodes a member of the AGC family of kinases that functions to regulate both actin-myosin-mediated cytokinesis and epigenetic gene silencing. FBgn0036294 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic hindgut; embryonic proventriculus inner layer; embryonic/larval muscle system; and embryonic/larval somatic muscle cell." FBgn0036292 Alliance Predicted to be involved in protein ubiquitination. Is expressed in adult head and organism. Orthologous to human EIPR1 (EARP complex and GARP complex interacting protein 1). FBgn0036289 Alliance "Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be located in endosome. Is expressed in several structures, including adult head; dorsal head epidermis; embryonic anal pad; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to several human genes including CLVS2 (clavesin 2) and RLBP1 (retinaldehyde binding protein 1)." FBgn0036288 Alliance Is expressed in anterior midgut primordium; embryonic Malpighian tubule; embryonic proventriculus; embryonic/larval midgut; and posterior midgut primordium. FBgn0036287 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0036285 FlyBase Gene Snapshot twin of eyg (toe) encodes a Pax6(5a) transcription factor that functions during thorax and eye development as a transcription repressor. FBgn0020655 Alliance Enables GTPase activator activity. Involved in negative regulation of endocytosis and regulation of ARF protein signal transduction. Located in Golgi stack. Is expressed in adult head. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). FBgn0052103 FlyBase Gene Snapshot "Short Calcium-binding Mitochondrial Carrier (SCaMC) encodes a mitochondrial carrier family protein with calcium-binding motifs. SCaMC transcripts are strongly detected in the corpora allata, suggesting its potential role in juvenile hormone biosynthesis." FBgn0036282 FlyBase Gene Snapshot "SET and MYND domain containing, class 4, member 2 (Smyd4-2) encodes a histone deacetylase involved in photoreceptor development, eclosion, and gene expression regulation." FBgn0052104 Alliance Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in cytoplasm. Orthologous to human RPAP1 (RNA polymerase II associated protein 1). FBgn0036279 FlyBase Gene Snapshot sodium chloride cotransporter 69 (Ncc69) encodes a member of the SLC12 family of Na[+]/K[+]/2Cl[-] cotransporters (NKCC). FBgn0036278 FlyBase Gene Snapshot Corazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. FBgn0011335 FlyBase Gene Snapshot versatile (vers) encodes a component of the heterochromatin protein 1 complex that regulates adult testis germline stem cell fate. FBgn0036248 FlyBase Gene Snapshot sunspot (ssp) encodes a protein that contributes to Wingless signaling and endoreplication. FBgn0036249 Alliance Predicted to enable DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. FBgn0046296 Alliance Is expressed in organism. Orthologous to human DEF8 (differentially expressed in FDCP 8 homolog). FBgn0036257 FlyBase Gene Snapshot "Rho GTPase activating protein at 68F (RhoGAP68F) encodes a GTPase activating protein acting upon small Rho-family GTPases involved in epithelial morphogenesis. It localizes to Rab4 recycling endosomes, forms a complex with the product of Rab4 and modulates the transport of Rab4 recycling endosomes back to the cell surface." FBgn0013997 FlyBase Gene Snapshot Neurexin IV (Nrx-IV) encodes a transmembrane protein that is critical for septate junction formation in epithelia and between ensheathing glial cells and neurons. FBgn0052099 Alliance Predicted to enable holo-[acyl-carrier-protein] synthase activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid. Predicted to be active in cytosol. Orthologous to human AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase). FBgn0027843 FlyBase Gene Snapshot Carbonic anhydrase 2 (CAH2) encodes an alpha-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons. FBgn0036262 Alliance Enables inositol oxygenase activity. Predicted to be involved in inositol catabolic process. Predicted to be located in cytoplasm. Is expressed in cardiogenic mesoderm; embryonic/larval fat body; fat body/gonad primordium; and trunk mesoderm. Orthologous to human MIOX (myo-inositol oxygenase). FBgn0000592 UniProtKB "Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology. (UniProtKB:P08171)" FBgn0000594 Alliance Enables carboxylesterase activity. Is expressed in organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0036264 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0052100 Alliance Involved in gravitaxis. FBgn0036273 UniProtKB "Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC. (UniProtKB:Q9VTW2)" FBgn0036274 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ganglia; midline primordium; ventral midline of embryo; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta)." FBgn0036272 Alliance "Enables spermine synthase activity. Involved in spermine biosynthetic process. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Used to study syndromic X-linked intellectual disability Snyder type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase)." FBgn0036271 Alliance "Enables porphobilinogen synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase)." FBgn0036266 Alliance Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Used to study pontocerebellar hypoplasia type 4. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). FBgn0022709 Alliance Enables adenylate kinase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). FBgn0036263 UniProtKB The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. (UniProtKB:Q9VTV1) FBgn0036260 FlyBase Gene Snapshot Rhodopsin 7 (Rh7) encodes a visual photoreceptor involved in circadian light entrainment. FBgn0036258 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q9VTU4)" FBgn0011455 FlyBase Gene Snapshot NADH dehydrogenase (ubiquinone) SGDH subunit (ND-SGDH) encodes a protein required for proper mitochondrial electron transport chain function. It is involved in longevity and redox response. FBgn0036254 Alliance "Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in anterior midgut primordium; organism; posterior midgut primordium; salivary gland body primordium; and trunk mesoderm. Orthologous to human KRI1 (KRI1 homolog)." FBgn0036250 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in larval abdomen. FBgn0022959 Interactive Fly "cold-shock domain protein involved in post-transcriptional regulation of Oskar mRNA - efficient Gurken protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex that includes Cup and Yps" FBgn0036205 Alliance Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be active in cytoplasm. FBgn0036207 Alliance "Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin)." FBgn0004381 FlyBase Gene Snapshot "Kinesin-like protein at 68D (Klp68D) encodes the kinesin-2beta motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp64D and Kap3. It plays an essential role in the sensory cilia assembly, microtubule organization in dendrites, and axonal transport." FBgn0036213 FlyBase Gene Snapshot Ribosomal protein L10Ab (RpL10Ab) is an essential gene during oogenesis that encodes a ribosomal protein of the large ribosome subunit. FBgn0036214 Alliance Is expressed in dorsal sensory complex proper primordium; embryonic head epidermis; sensory nervous system primordium; spermatozoon; and ventral sensory complex primordium. Orthologous to several human genes including RIBC2 (RIB43A domain with coiled-coils 2). FBgn0036218 FlyBase Gene Snapshot "Spermitin (Sprn) encodes a testis-specific mitochondrial lumen protein that first appears during the spermatocyte stage of spermatogenesis, and persists until late stages but is absent from mature sperm." FBgn0036219 Alliance "Involved in negative gravitaxis. Located in several cellular components, including cell body; ciliary rootlet; and ciliary tip. Is expressed in chordotonal neurons and chordotonal organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3)." FBgn0011723 FlyBase Gene Snapshot "brachyenteron (byn) encodes a T-domain transcriptional activator that acts in developmental specification, in particular it specifies posterior gut structures and a subset of posteriorly derived visceral muscles." FBgn0036224 Alliance "Predicted to enable proteasome-activating activity. Predicted to be involved in ERAD pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of cytosolic proteasome complex and proteasome regulatory particle, base subcomplex. Is expressed in organism. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6)." FBgn0036226 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036227 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036229 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic midgut chamber. FBgn0036232 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036235 Alliance "Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Scott syndrome; bone disease (multiple); dystonia 24; isolated elevated serum creatine phosphokinase levels; and muscular dystrophy (multiple). Orthologous to several human genes including ANO4 (anoctamin 4)." FBgn0036236 Alliance Orthologous to human TPGS2 (tubulin polyglutamylase complex subunit 2). FBgn0036240 Alliance Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval posterior spiracle; embryonic/larval salivary gland; embryonic/larval salivary gland body; and organism. Orthologous to human SLC26A11 (solute carrier family 26 member 11). FBgn0041096 FlyBase Gene Snapshot rolling pebbles (rols) encodes a protein required for myoblast fusion in founder cells. it interacts with the membrane spanning Immunoglobulin superfamily protein encoded by kirre and with the product of Mhcl. FBgn0036239 FlyBase Gene Snapshot Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition. FBgn0026432 FlyBase Gene Snapshot Grip163 (Grip163) encodes a gamma-tubulin binding protein involved in the mitotic cell cycle. FBgn0036237 UniProtKB Modulates the activation of caspases during apoptosis. (UniProtKB:Q8MR62) FBgn0053265 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval proventriculus and organism. FBgn0028573 FlyBase Gene Snapshot pericardin (prc) encodes a type IV collagen-like extracellular matrix protein involved in heart development. FBgn0036230 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036228 Alliance Predicted to enable chitin binding activity. Predicted to be located in chitin-based extracellular matrix. FBgn0036225 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036222 Alliance "Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in adult head and spermatozoon." FBgn0036220 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036217 Alliance Predicted to enable monoatomic ion channel activity. Predicted to be involved in mitochondrial ribosome assembly and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). FBgn0000404 FlyBase Gene Snapshot "Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity." FBgn0052095 Alliance Is expressed in organism. FBgn0036211 Alliance "Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Involved in regulation of lipid storage. Located in endomembrane system. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to several human genes including CYB5R3 (cytochrome b5 reductase 3)." FBgn0036212 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. FBgn0052093 Alliance Predicted to enable CAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0036208 Alliance "Predicted to enable glycine C-acetyltransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in biosynthetic process and threonine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic/larval somatic muscle cell; and sensory nervous system primordium. Orthologous to human GCAT (glycine C-acetyltransferase)." FBgn0036206 Alliance Involved in cytosolic ciliogenesis and non-motile cilium assembly. Part of ciliary transition fiber. Is expressed in Johnston organ; antennal segment 3 sense organ; scolopidial cilium; spermatid; and spermatocyte. Orthologous to human FBF1 (Fas binding factor 1). FBgn0015278 FlyBase Gene Snapshot Phosphotidylinositol 3 kinase 68D (Pi3K68D) encodes a phosphatidylinositol kinase involved in the organization of the cortical actin cytoskeleton and the regulation of the Egfr signaling pathway. FBgn0036204 UniProtKB Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The Tim8-Tim13 complex mediates the import of some proteins while the predominant Tim9-Tim10 70 kDa complex mediates the import of much more proteins (By similarity). (UniProtKB:Q9VTN3) FBgn0028667 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Is expressed in adult head. Used to study early-onset epilepsy 3. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c)." FBgn0028668 FlyBase Gene Snapshot "Vacuolar H[+] ATPase 16kD subunit 2 (Vha16-2) encodes the main subunit of the membrane-embedded V0 sector of the vacuolar-ATPase, which is responsible for acidification of the endo-lysosomal lumen and other cellular compartment. As part of the V-ATPase, the product of Vha16-2 supports membrane trafficking, protein degradation and multiple associated signaling pathways, such as mTor, Wnt and Notch." FBgn0003377 FlyBase Gene Snapshot Salivary gland secretion 7 (Sgs7) encodes one of the 20-hydroxyecdysone-induced proteins secreted at the larval-to-prepupal transition. They form a glue that serves to attach the prepupa and pupa to a solid substrate. FBgn0003373 Alliance "Predicted to be an extracellular matrix structural constituent. Involved in puparial adhesion. Located in adhesive extracellular matrix. Is expressed in several structures, including adult heart; embryonic/larval Malpighian tubule; embryonic/larval fat body; embryonic/larval proventriculus; and salivary gland." FBgn0036168 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Predicted to be active in nucleus. Orthologous to human CASZ1 (castor zinc finger 1)." FBgn0036173 UniProtKB "Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). (UniProtKB:Q9VTJ8)" FBgn0036179 Alliance Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. FBgn0036184 UniProtKB "Required for the export of nuclear mRNAs and involved in mRNA trafficking in the cytoplasm (PubMed:27016737, PubMed:28554770, PubMed:33602059). Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:27016737, PubMed:28554770, PubMed:33602059). Within the complex, specifically promotes the association of factors involved in regulating nuclear mRNA export, such as Moe, sbr/NXF1 and the ORC complex, to the mRNPs particles (PubMed:27016737, PubMed:28554770, PubMed:33602059). In the cytoplasm, functions independently of its role in the TREX-2/AMEX complex, to promote cytoplasmic mRNA trafficking together with nudC (PubMed:33602059). Associates with translationally active polysomes (PubMed:18086857). (UniProtKB:Q9VTL1)" FBgn0042138 Alliance "Enables serine hydrolase activity. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; central nervous system; germ layer; and supraesophageal ganglion. Orthologous to several human genes including LYPLA1 (lysophospholipase 1)." FBgn0052091 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4). FBgn0036188 Alliance Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3H (RNA polymerase III subunit H). FBgn0015828 FlyBase Gene Snapshot Transcription factor IIEalpha (TfIIEalpha) encodes the large subunit of the RNA polymerase II general transcription factor TFIIE. The products of TfIIEalpha and TfIIEbeta are essential for transcription initiation in vitro acting with RNA polymerase II and the other general transcription factors. FBgn0036191 FlyBase Gene Snapshot Sugar baby (Sugb) encodes a protein that determines lifespan. FBgn0036193 Alliance Predicted to enable sequence-specific DNA binding activity. FBgn0036199 UniProtKB Regulates metabolic homeostasis in response to nutritional cues and may therefore be involved in adaptation to dietary variations. May not function in creating mitochondrial proton leaks across the inner mitochondrial membrane (i.e. mitochondrial uncoupling). (UniProtKB:Q7K566) FBgn0052087 Alliance Predicted to be involved in Golgi organization; autophagosome assembly; and cell-cell adhesion. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in adult head. Orthologous to human VMP1 (vacuole membrane protein 1). FBgn0041231 FlyBase Gene Snapshot Gustatory receptor 68a (Gr68a) encodes a member of the seven-transmembrane chemoreceptor family expressed in gustatory sensilla receptor neurons. It mediates courtship behavior and functions as a sensor for sex pheromones and mechanosensory stimuli. FBgn0036202 Alliance Located in cytoplasm. Is expressed in adult head; embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and organism. FBgn0040817 Alliance Predicted to be located in extracellular space. FBgn0036198 FlyBase Gene Snapshot crimpled (crim) encodes a protein involved in tracheal system development and the localization of septate junction components. FBgn0036196 Alliance "Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; embryonic/larval muscle system; somatic muscle primordium; and trunk mesoderm. Used to study attention deficit hyperactivity disorder. Orthologous to human FBXO25 (F-box protein 25) and FBXO32 (F-box protein 32)." FBgn0036195 FlyBase Gene Snapshot "dynein, axonemal, intermediate chain 2 (Dnai2) encodes a subunit of the axonemal dynein complex. It is involved in the perception of sound and sperm competititon." FBgn0036194 Alliance "Predicted to enable 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be located in cytoplasm. Is expressed in several structures, including amnioserosa; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 1. Orthologous to human DPH1 (diphthamide biosynthesis 1)." FBgn0036192 FlyBase Gene Snapshot Pallidin (Pldn) encodes a core component of the biogenesis of lysosome-related organelles (BLOC-1) complex. It is involved in pigment granule biogenesis and synaptic vesicle recycling at the neuromuscular junction. FBgn0052085 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL16 (F-box and leucine rich repeat protein 16). FBgn0036187 Alliance "Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of glial cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human RIOK1 (RIO kinase 1)." FBgn0036186 Alliance Predicted to enable zinc ion binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0036183 Alliance "Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; congenital bile acid synthesis defect 2; and leukemia. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10) and AKR1B15 (aldo-keto reductase family 1 member B15)." FBgn0036181 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval midgut; embryonic/larval salivary gland; and organism. FBgn0003292 FlyBase Gene Snapshot "rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion." FBgn0052086 Alliance Orthologous to human EFHB (EF-hand domain family member B). FBgn0003378 FlyBase Gene Snapshot Salivary gland secretion 8 (Sgs8) encodes one of the 20-hydroxyecdysone-induced proteins secreted at the larval-to-prepupal transition. They form a glue that serves to attach the prepupa and pupa to a solid substrate. FBgn0036142 Alliance Predicted to be involved in lipid homeostasis and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human ADCK5 (aarF domain containing kinase 5). FBgn0036143 Alliance Predicted to enable K48-linked deubiquitinase activity. Orthologous to several human genes including MINDY4B (MINDY family member 4B). FBgn0036146 Alliance Located in extracellular space. FBgn0064766 Alliance Orthologous to human FAM91A1 (family with sequence similarity 91 member A1). FBgn0041094 UniProtKB Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development. (UniProtKB:Q9VTH4) FBgn0036153 Alliance Predicted to be involved in CAAX-box protein processing. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). FBgn0036156 Alliance Predicted to enable mRNA binding activity. FBgn0036157 Alliance "Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase)." FBgn0036161 Alliance "Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase)." FBgn0036162 Alliance Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). FBgn0036160 Alliance "Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase)." FBgn0036158 Alliance Predicted to be located in membrane. Predicted to be active in endomembrane system. Is expressed in adult head. Orthologous to several human genes including AIG1 (androgen induced 1). FBgn0036155 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism. FBgn0036154 FlyBase Gene Snapshot CG6168 encodes a predicted metalloendopeptidase that is produced by the male accessory glands. CG6168 ectopic expression in females provides anti-microbial protection. FBgn0036152 Alliance "Located in nucleus. Is expressed in several structures, including clypeo-labral primordium; embryonic epipharynx; embryonic hindgut; embryonic hypopharynx; and mesoderm." FBgn0036150 Alliance "Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in several structures, including adult antennal lobe receptor neurons; external compound sense organ; organism subdivision; synaptic neuropil domain; and synaptic neuropil subdomain." FBgn0061469 FlyBase Gene Snapshot "Ubiquitin protein ligase E3A (Ube3a) encodes the founding member of the HECT-type ubiquitin E3 ligase family of enzymes. It is involved in the final step of conjugation of ubiquitin to its target substrates. It regulates protein degradation by targeting modified proteins to the proteasome or by regulating the proteasome activity through ubiquitination of its subunits, which in turn affects many aspects of neuronal function, such as synaptic plasticity, long-term memory or dendritic development." FBgn0036147 FlyBase Gene Snapshot procollagen lysyl hydroxylase (Plod) encodes a lysyl dehydrogenase with roles in Collagen IV biosynthesis. It localizes to the endoplasmic reticulum and is required for the secretion Collagen IV from haemocytes and fat body. FBgn0036108 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0036109 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0036110 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Involved in sexual reproduction. Located in extracellular space. FBgn0029172 FlyBase Gene Snapshot Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones. FBgn0052079 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen and adult thorax. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0052081 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0036116 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen; adult head; adult thorax; embryonic/larval salivary gland; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0036118 UniProtKB Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (UniProtKB:Q9VTE0) FBgn0025355 FlyBase Gene Snapshot Suppressor of Under-Replication (SuUR) encodes a chromatin binding protein involved in heterochromatin assembly and regulation of the DNA endoreduplication. FBgn0036124 FlyBase Gene Snapshot "Nucleolar complex protein 1 (Noc1) encodes a protein expressed in the nucleolus, and whose reduction affects rRNA maturation and protein synthesis, inducing apoptosis." FBgn0036133 FlyBase Gene Snapshot emei (emei) encodes a regulator of calcium levels localized to the endoplasmatic reticulum. Loss of emei synergizes with oncogenic Ras85D to promote tumor growth via JNK-mediated Hippo signaling. FBgn0036135 Alliance "Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human MRPL2 (mitochondrial ribosomal protein L2)." FBgn0052082 FlyBase Gene Snapshot Insulin receptor substrate 53 kDa (IRSp53) encodes a protein required for filopodia formation during the adhesion and fusion of myoblasts. FBgn0052076 UniProtKB "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol. (UniProtKB:Q8T8L8)" FBgn0036141 FlyBase Gene Snapshot "wntless (wls) encodes a multiple-pass transmembrane protein specifically required for the secretion of Wnt proteins. Its roles include growth regulation, cell survival and developmental patterning." FBgn0036136 UniProtKB Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. (UniProtKB:Q9VTF9) FBgn0036134 FlyBase Gene Snapshot "Forkhead box K (FoxK) encodes a transcription factor in the Fork Head family. It is a direct target of Dpp/BMP signaling during midgut development, and in turn regulates the homeobox gene lab to determine endoderm differentiation. It also regulates antiviral gene expression." FBgn0003462 UniProtKB Destroys radicals which are normally produced within the cells and which are toxic to biological systems. (UniProtKB:P61851) FBgn0036128 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in corneal dystrophy and spinocerebellar ataxia type 34. Orthologous to human ELOVL4 (ELOVL fatty acid elongase 4). FBgn0036126 Interactive Fly "bZIP transcription factor - Minute cell competition, arising from mutation of ribosomal proteins, requires the transcription factors Irbp18 and Xrp1 - Xrp1 forms heterodimers with Irbp18, and removal of Irbp18 also strongly suppresses the competitive elimination of Rp/+ cells in mosaic tissues - IRBP18/Xrp1 heterodimer binds sequence-specifically to its dsDNA-binding site within P-element terminal inverted repeats - both proteins are critical for repair of DNA breaks following transposase cleavage in vivo" FBgn0020412 FlyBase Gene Snapshot JIL-1 kinase (JIL-1) encodes a Serine/Threonine tandem kinase that phosphorylates the Serine 10 residue of the product of His3. A key function of the product of JIL-1 is to antagonize heterochromatization and to regulate levels of gene expression by controlling the distribution of the Lysine 9 dimethylation mark of the epigenetic histone encoded by His3. FBgn0010741 UniProtKB Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). (UniProtKB:Q9VTE5) FBgn0036121 Alliance Is expressed in adult head and adult heart. FBgn0052075 Alliance "Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor)." FBgn0052069 Alliance Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to human IER3IP1 (immediate early response 3 interacting protein 1). FBgn0036117 Alliance "Predicted to enable 2-aminoadipate transaminase activity. Predicted to be involved in biosynthetic process. Is expressed in several structures, including adult fat body; gland; and gut section. Orthologous to human AADAT (aminoadipate aminotransferase)." FBgn0013469 Interactive Fly "transcription factor - zinc finger - early growth response family - involved in determination of the identities of secondary precursor cells within neuroblast lineages in the central nervous system - a genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS" FBgn0036111 FlyBase Gene Snapshot Aps (Aps) encodes a diphosphoinositol-polyphosphate diphosphatase that hydrolyses a range of (di)nucleoside polyphosphates. It is involved in glucose and lipid homeostasis. FBgn0001179 FlyBase Gene Snapshot "haywire (hay) encodes a ATP-dependent 3'-5' DNA helicase based on the similarity with the human gene XPB, which is a subunit of the DNA repair and basal transcription factor TFIIH. The product of hay contributes to response to UV and homeotic gene expression." FBgn0036090 UniProtKB May form with the serine/threonine protein phosphatase l(1)G0269 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (By similarity). (UniProtKB:Q8T0B1) FBgn0036091 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in spermatheca and testis. FBgn0036096 Alliance Is expressed in adult head and organism. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). FBgn0052068 FlyBase Gene Snapshot Acireductone dioxygenase 1 (Adi1) encodes an enzyme in the methionine salvage pathway (MTA cycle) that is required for fecundity. FBgn0010762 FlyBase Gene Snapshot "simjang (simj) encodes a component of the NURD complex, which couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. The product of simj is involded in cardiogenesis and habituation." FBgn0036099 Alliance "Predicted to enable guanylate kinase activity. Predicted to be involved in purine nucleotide metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut; embryonic/larval midgut interstitial cell; and embryonic/larval midgut primordium. Orthologous to human GUK1 (guanylate kinase 1)." FBgn0036102 Alliance Is expressed in organism. FBgn0026160 FlyBase Gene Snapshot "tonalli (tna) is an essential gene that encodes several isoforms, including Tna-A, which physically associates with subunits of the Brahma chromatin remodeling complex and is involved in transcriptional activation." FBgn0036105 UniProtKB Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (UniProtKB:Q9VTC2) FBgn0036107 UniProtKB "Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex. (UniProtKB:Q9VTC4)" FBgn0027615 Interactive Fly "membrane insertase, mediates mitochondrial membrane insertion of cytochrome c oxidase proteins, localizes to cristae and reticular structures isolated in the matrix in addition to the inner boundary membrane, suggesting that it may participate in the formation of vesicle germination-derived cristae P" FBgn0036106 Alliance Is expressed in adult hemolymph; embryonic anal pad; embryonic large intestine; and embryonic ventral epidermis. FBgn0036104 Alliance "Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in protein localization. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval nervous system; ganglia; pole plasm; and tracheal primordium. Orthologous to human DDX42 (DEAD-box helicase 42)." FBgn0047038 Alliance "Predicted to be involved in respiratory electron transport chain. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Orthologous to human NDUFA5 (NADH:ubiquinone oxidoreductase subunit A5)." FBgn0052066 Alliance "Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Located in perivitelline space. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and synaptic neuropil domain. Orthologous to human CYRIA (CYFIP related Rac1 interactor A) and CYRIB (CYFIP related Rac1 interactor B)." FBgn0000629 FlyBase Gene Snapshot "Enhancer of zeste (E(z)) encodes the catalytic component of the Polycomb Repressive Complex 2 (PRC2) methyltransferase that methylates histone H3 lysine27. Together with PRC1, PRC2 silences developmental genes to determine specific differentiated cell identities." FBgn0036082 Alliance Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). FBgn0045770 Alliance Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0052064 Alliance Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0052062 FlyBase Gene Snapshot "RNA-binding Fox protein 1 (Rbfox1) encodes RNA-binding proteins that bind to (U)GCAUG elements. Nuclear isoforms of the product of Rbfox1 regulate tissue specific alternative splicing, while cytoplasmic isoforms regulate mRNA translation. It functions in a number of processes, including germline cyst development." FBgn0036085 Alliance Predicted to enable FFAT motif binding activity. Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum-plasma membrane tethering. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. FBgn0011802 FlyBase Gene Snapshot "Gemin 3 (Gem3) encodes an RNA helicase and a member of the SMN-Gemins complex. It is a component of the cytoplasmic U snRNP body and nuclear gems. It is required in the motor system for viability, neuromuscular junction development and motor behaviour." FBgn0052058 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in chemosensory neuron of adult labral sensillum 7; gustatory receptor neuron of the epiphysis; and labral sense organ neurons. FBgn0036083 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis and larval abdomen. FBgn0036070 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GLIPR1 (GLI pathogenesis related 1) and CRISP1 (cysteine rich secretory protein 1). FBgn0036080 FlyBase Gene Snapshot "Odorant receptor 67d (Or67d) encodes a member of the odorant receptor family of ligand gated ion channels required for detection of the pheromone cVA by olfactory neurons. The neurons expressing Or67d are fru positive and mediate sexually dimorphic social behaviors including courtship and mating, aggregation and aggression." FBgn0011569 FlyBase Gene Snapshot cannonball (can) encodes a testis-specific TBP-associated factor essential for spermatogenesis. It is required for the normal level of expression of a large number of spermatogenesis genes and is strongly associated with the nucleolus in primary spermatocytes. FBgn0052055 Alliance Predicted to be active in extracellular space. Orthologous to human CPN2 (carboxypeptidase N subunit 2). FBgn0000451 Alliance "Involved in cuticle development and tube development. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic hypopharynx; epidermis; and gut section." FBgn0052057 Alliance Involved in synapse organization. Located in neuron projection membrane. Is expressed in adult mushroom body alpha'-lobe; adult mushroom body alpha-lobe; adult mushroom body gamma-lobe; larval ventral nerve cord; and medulla. FBgn0036072 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0052054 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in hexose transmembrane transport. Predicted to be located in membrane. FBgn0052053 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in hexose transmembrane transport. Predicted to be located in membrane. Is expressed in organism and posterior endoderm anlage. FBgn0036066 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in lamina and photoreceptor cell R8. FBgn0036043 Alliance "Predicted to enable transmembrane transporter activity. Involved in intracellular pH reduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult brain; adult head; embryonic/larval central nervous system; embryonic/larval midgut enterocyte; and ganglia. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; osteopetrosis; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)); SLC4A2 (solute carrier family 4 member 2); and SLC4A3 (solute carrier family 4 member 3)." FBgn0044051 Interactive Fly "ligand of the insulin/IGF-signaling pathway - expressed in brain neurosecretory cells of larvae, pupae, and adults - Mutation diminishes organismal weight during pupal development, whereas overexpression increases it - survival during starvation is strongly diminished in mutants - overexpression decreases survival during starvation in female flies and increases egg laying and decreases egg to pupal viability - mutants extend lifespan and increase Akh mRNA and protein in a dilp1-dependent manner - expressed in non-feeding stages and in diapausing flies - is under feedback regulation and appears to play sex-specific functional roles" FBgn0036046 FlyBase Gene Snapshot "Insulin-like peptide 2 (Ilp2) encodes a protein which, like human insulin, activates the insulin signaling pathway to control growth and metabolism." FBgn0044328 Alliance Predicted to enable phosphoric diester hydrolase activity. Predicted to be active in extracellular space. Is expressed in adult head and embryonic head sensory system. Orthologous to several human genes including SMPDL3B (sphingomyelin phosphodiesterase acid like 3B). FBgn0027567 Alliance Predicted to be located in nucleus. Is expressed in adult head. Orthologous to human CIZ1 (CDKN1A interacting zinc finger protein 1). FBgn0025866 UniProtKB Calcium-regulated non-lysosomal thiol-protease. ACTIVITY REGULATION: Activated by millimolar concentrations of calcium. (UniProtKB:Q9VT65) FBgn0036059 FlyBase Gene Snapshot "nudE (nudE) encodes a conserved protein that localizes to kinetochores and spindle microtubules. It contributes to the spindle checkpoint, spindle orientation, centrosome behavior and dendrite morphogenesis." FBgn0026404 FlyBase Gene Snapshot "Death regulator Nedd2-like caspase (Dronc) encodes an initiator caspase that is essential for caspase-dependent cell death. It is also implicated in the DNA damage response, sperm differentiation and cell specification." FBgn0040823 Alliance Involved in synapse organization. Located in neuron projection membrane. Is expressed in larval ventral nerve cord; medulla; and organism. FBgn0036063 Alliance Orthologous to human TSSC4 (tumor suppressing subtransferable candidate 4). FBgn0036058 Alliance "Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in bounding membrane of organelle and plasma membrane. Is expressed in adult head and organism. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1) and PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2)." FBgn0036057 UniProtKB May have an accessory function in the survival motor neuron (SMN) complex. (UniProtKB:Q9VT67) FBgn0011836 FlyBase Gene Snapshot "TBP-associated factor 2 (Taf2) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. Together with the product of Taf1, it binds the Initiator and/or the DPE core promoter elements." FBgn0036053 FlyBase Gene Snapshot "calcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome." FBgn0036052 Alliance Orthologous to human ANKRD54 (ankyrin repeat domain 54). FBgn0004390 UniProtKB Inhibitory regulator of the Ras-cyclic AMP pathway. May function as a negative regulator of Ras85D/Ras1 in the sev signaling pathway. Acts cell autonomously in cone cell precursors as a negative regulator of R7 photoreceptor cell determination. (UniProtKB:P48423) FBgn0015618 UniProtKB "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation. (UniProtKB:Q9VT57)" FBgn0028429 FlyBase Gene Snapshot Inhibitor-2 (I-2) encodes a protein phosphatase 1 inhibitor. FBgn0044048 FlyBase Gene Snapshot "Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females." FBgn0044049 FlyBase Gene Snapshot Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior. FBgn0044050 FlyBase Gene Snapshot "Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females." FBgn0036044 FlyBase Gene Snapshot "Z band alternatively spliced PDZ-motif protein 67 (Zasp67) encodes a member of the Zasp protein family. It is expressed during pupal development and plays a role in adult muscle development, especially in myofibril assembly." FBgn0036009 FlyBase Gene Snapshot Odorant receptor 67a (Or67a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0036014 Alliance Orthologous to human MORN5 (MORN repeat containing 5). FBgn0036016 Alliance Orthologous to human MORN5 (MORN repeat containing 5). FBgn0036018 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nuclear speck and nucleolus. Is expressed in spermatozoon. Orthologous to human RBM19 (RNA binding motif protein 19)." FBgn0036020 FlyBase Gene Snapshot "Cyclophilin 40 (Cyp40) encodes a protein with essential functions in germ cells during sperm maturation. As a co-chaperone of Hsp83, Cyp40 forms complexes with Argonaute (Ago) proteins and small RNA intermediate duplexes, and controls the silencing effector formation by AGO2 in the testis." FBgn0036022 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0036023 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0036024 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0036028 FlyBase Gene Snapshot "Metallophosphoesterase domain containing (Mpped) encodes a Class III metallophosphodiesterase which hydrolyzes phosphodiester substrates including cAMP and cGMP in a metal-dependent manner. Mpped knockout flies show reduced lifespan, defective specific attractant perception and desiccation sensitivity." FBgn0036029 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in regulation of cytoskeleton organization. Predicted to be active in axoneme. Is expressed in adult head. Orthologous to human SPEF1 (sperm flagellar 1). FBgn0015321 UniProtKB Catalyzes the covalent attachment of ubiquitin to other proteins. (UniProtKB:P52486) FBgn0045823 FlyBase Gene Snapshot "visgun (vsg) encodes a protein involved in cell proliferation regulation, response to ethanol and long-term memory." FBgn0036036 Alliance Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein). FBgn0036038 FlyBase Gene Snapshot "deflated (defl) encodes a component of 'Integrator', a multi-subunit protein complex that binds to the C-terminal domain of RNA polymerase II and is involved in RNA transcript processing and maturation." FBgn0019644 FlyBase Gene Snapshot "ATP synthase, subunit B (ATPsynB) encodes a protein proposed to act in ATP synthesis and phagocytosis. Ubiquitous knockdown of ATPsynB results in larval growth defects, while knockdown in testes causes male infertility." FBgn0036040 Alliance Orthologous to human CPN2 (carboxypeptidase N subunit 2). FBgn0036035 Alliance "Predicted to enable rRNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Predicted to be part of preribosome, large subunit precursor. Is expressed in adult head and organism." FBgn0040475 Alliance "Enables kinase binding activity. Involved in several processes, including cellular response to hypoxia; lamellipodium assembly; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in several cellular components, including neuronal cell body; presynaptic membrane; and subsynaptic reticulum. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval midgut; embryonic/larval neurons; and larval ventral nerve cord. Used to study colorectal cancer. Orthologous to several human genes including SNX9 (sorting nexin 9)." FBgn0036031 Alliance Is expressed in spermatozoon. Orthologous to human SANBR (SANT and BTB domain regulator of CSR). FBgn0036030 Alliance "Predicted to enable ATP binding activity and ribose phosphate diphosphokinase activity. Involved in olfactory behavior. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; embryonic/larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2)." FBgn0016081 FlyBase Gene Snapshot "furry (fry) encodes a large conserved protein that functions with the product of trc. Its mutations lead to mulitpled hairs, split and multipled arista laterals and to defects in dendritic tiling." FBgn0036019 FlyBase Gene Snapshot Odorant receptor 67b (Or67b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0036015 Alliance Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0036010 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the ventral organ; mesothoracic leg taste bristle chemosensory neurons; metathoracic leg taste bristle chemosensory neurons; and prothoracic leg taste bristle chemosensory neurons. FBgn0010408 FlyBase Gene Snapshot Ribosomal protein S9 (RpS9) encodes a structural constituent of ribosomes. FBgn0036008 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including CNS glial cell; adult head; central brain primordium; embryonic central brain neurons; and ganglia. Orthologous to human LRRC59 (leucine rich repeat containing 59)." FBgn0036007 UniProtKB "Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline (PubMed:15843412). Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197). Required in a cell-autonomous manner for dendrite growth in neurons with large dendrite arbors (PubMed:26063572, PubMed:26735916). (UniProtKB:Q9VT04)" FBgn0035969 FlyBase Gene Snapshot CG4476 encodes an orphan member of the SLC6 family of transporters that includes the plasma membrane serotonin and dopamine transporters. CG4476 mutants show a decreased behavioral response to light. FBgn0035971 Alliance Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in extracellular space. FBgn0035975 FlyBase Gene Snapshot Peptidoglycan recognition protein LA (PGRP-LA) encodes a protein implicated in the regulation of the immune deficiency pathway in some epithelia. FBgn0035977 FlyBase Gene Snapshot Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. FBgn0052039 Alliance Involved in autophagosome-lysosome fusion and lysosomal membrane organization. Located in lysosomal membrane. Orthologous to human SVIP (small VCP interacting protein). FBgn0035980 Alliance Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human MRRF (mitochondrial ribosome recycling factor). FBgn0035982 Alliance Predicted to enable unfolded protein binding activity. Involved in response to heat. Predicted to be active in cytoplasm and nucleus. FBgn0001224 FlyBase Gene Snapshot "Heat shock protein 23 (Hsp23) encodes a protein involved in protein folding. It contributes to the response to cold, heat and hypoxia." FBgn0035985 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult fat body and adult head. FBgn0023129 UniProtKB Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity). (UniProtKB:Q9VSY6) FBgn0015296 FlyBase Gene Snapshot SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. FBgn0040305 FlyBase Gene Snapshot "Metal response element-binding Transcription Factor-1 (MTF-1) encodes a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of non-essential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer encoded by Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal." FBgn0035995 Alliance "Predicted to enable clathrin binding activity. Predicted to be involved in signal transduction. Predicted to be active in endosome and membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including TOM1L2 (target of myb1 like 2 membrane trafficking protein) and TOM1 (target of myb1 membrane trafficking protein)." FBgn0035999 Alliance Predicted to enable GDP-D-glucose phosphorylase activity. Predicted to be involved in glucose metabolic process. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human GDPGP1 (GDP-D-glucose phosphorylase 1). FBgn0036004 FlyBase Gene Snapshot "Jumonji, AT rich interactive domain 2 (Jarid2) encodes a nuclear protein that functions as a DNA-binding transcriptional repressor. It functions as a scaffold for the recruitment of various complexes, including Polycomb repressive complex 2. It is involved in intestinal stem proliferation and differentiation." FBgn0052037 Alliance Is expressed in dorsal epidermis primordium; embryonic dorsal apodeme; embryonic dorsal epidermis; and embryonic head sensory system. FBgn0052036 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0036005 FlyBase Gene Snapshot "pallbearer (pall) encodes an F-Box protein. In response to apoptosis, it translocates from the nucleus to the cytoplasm of macrophages to promote apoptotic cell clearance by degrading the product of RpS6, and promote actin remodeling through activation of the product of Rac2." FBgn0011327 FlyBase Gene Snapshot "Ubiquitin carboxy-terminal hydrolase L5 (Uch-L5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus." FBgn0036000 UniProtKB "Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4, 5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). (UniProtKB:Q9VSZ6)" FBgn0035998 Alliance Predicted to be involved in centrosome duplication and spindle assembly. Predicted to be active in centrosome; nucleus; and spindle. Is expressed in organism. Orthologous to human SAC3D1 (SAC3 domain containing 1). FBgn0035997 FlyBase Gene Snapshot "pleiohomeotic like (phol) encodes a zinc-finger protein that is 80% identical in the zinc-finger region to the product of pho. The product of phol plays a role in Polycomb group protein recruitment to Polycomb response elements, but it has additional roles, most likely as a transcriptional activator." FBgn0035996 Alliance Predicted to enable DNA binding activity. Predicted to be involved in DNA ligation involved in DNA repair; double-strand break repair via nonhomologous end joining; and response to X-ray. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. FBgn0005533 FlyBase Gene Snapshot "Ribosomal protein S17 (RpS17) encodes an essential component of the ribosomal 40S subunit. RpS17 mutants have dominant, haploinsufficient effects on cellular and organismal growth rate, and on bristle size." FBgn0035989 UniProtKB "Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules (By similarity) (PubMed:36302967). Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released (By similarity). Acetylates central spindle microtubules (PubMed:36302967). (UniProtKB:Q9VSY4)" FBgn0035986 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval nervous system; and ganglia. Orthologous to human PIH1D2 (PIH1 domain containing 2)." FBgn0015218 FlyBase Gene Snapshot eukaryotic translation initiation factor 4E1 (eIF4E1) encodes a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. The product of eIF4E1 binds the 7-methyl-guanosine cap structure of mRNA. FBgn0035983 Alliance "Predicted to enable MHC protein binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Predicted to be located in plasma membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and posterior endoderm. Orthologous to several human genes including MARCHF8 (membrane associated ring-CH-type finger 8)." FBgn0001227 Alliance Predicted to enable unfolded protein binding activity. Involved in response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). FBgn0001225 FlyBase Gene Snapshot Heat shock protein 26 (Hsp26) encodes a protein involved in protein folding. It contributes to lifespan determination and the response to cold and heat. FBgn0001229 FlyBase Gene Snapshot "Heat shock gene 67Bc (Hsp67Bc) encodes a small heat shock protein (hsp) that binds to the product encoded by stv to regulate protein lipidation. The product of Hsp67Bc also induces the phosphorylation of eIF2alpha protein and stimulates autophagy, thereby facilitating the clearance of misfolded proteins. Hsp67Bc expression can be regulated by the product of pcm." FBgn0011769 UniProtKB Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. (UniProtKB:P37193) FBgn0004379 FlyBase Gene Snapshot Kinesin-like protein at 67A (Klp67A) encodes a microtubule motor protein involved in chromosome congression and mitotic spindle morphogenesis. FBgn0035970 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in adult head; embryonic/larval brain; embryonic/larval central nervous system; and organism. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). FBgn0035968 FlyBase Gene Snapshot Solute carrier family 45 member 1 (Slc45-1) encodes a proton/sucrose symporter occuring in apical membranes of the late embryonic hindgut as well as in vesicular membranes of ovarian follicle cells. It may either serve as an osmolyte transporter or be responsible for the resorption of sucrose. FBgn0035993 FlyBase Gene Snapshot "Nuclear factor Y-box A (Nf-YA) encodes a subunit of the nuclear transcription factor Y (NF-Y), also known as the CCAAT motif-binding factor (CBF). It is involved in eye and thorax development via gene expression regulation." FBgn0035936 FlyBase Gene Snapshot "Tetraspanin 66E (Tsp66E) encodes a tetraspanin, which spans the membrane four times. When the products of both Tsp66E and Tsp74F are removed, this results in defects in actin polarization, endocytosis, and distribution of the integrin subunit encoded by if during oogenesis." FBgn0040321 FlyBase Gene Snapshot Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. FBgn0011787 FlyBase Gene Snapshot mitochondrial ribosomal protein L12 (mRpL12) encodes a protein required for Cyclin D/Cdk4-driven cell growth. FBgn0035941 Alliance Is expressed in embryonic anal pad; embryonic hindgut; embryonic large intestine; hindgut proper primordium; and large intestine primordium. FBgn0035944 Alliance "Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gland; and gut section. Orthologous to several human genes including TVP23A (trans-golgi network vesicle protein 23 homolog A) and TVP23B (trans-golgi network vesicle protein 23 homolog B)." FBgn0035947 UniProtKB "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), Srp72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity). (UniProtKB:Q9VSS2)" FBgn0035951 Alliance Enables serine hydrolase activity. Is expressed in adult head and organism. Orthologous to human PPME1 (protein phosphatase methylesterase 1). FBgn0035953 Alliance Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is expressed in adult head; embryonic anal pad; embryonic hindgut; embryonic large intestine; and organism. Human ortholog(s) of this gene implicated in Kaufman oculocerebrofacial syndrome. Orthologous to human UBE3B (ubiquitin protein ligase E3B). FBgn0035954 FlyBase Gene Snapshot "Dorsocross3 (Doc3) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives." FBgn0028789 FlyBase Gene Snapshot "Dorsocross1 (Doc1) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives." FBgn0035957 Alliance "Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to be active in extracellular space. Is expressed in adult head and spermatozoon. Orthologous to several human genes including CKB (creatine kinase B); CKM (creatine kinase, M-type); and CKMT1A (creatine kinase, mitochondrial 1A)." FBgn0035960 Alliance Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). FBgn0023479 Alliance Predicted to enable serine-type endopeptidase activity. Involved in glucose homeostasis; memory; and positive regulation of insulin secretion. Predicted to be located in extracellular region and membrane. Is expressed in adult brain; adult head; eye; and neuron of the dorsal anterior lateral group of the protocerebrum. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). FBgn0043806 Alliance Is expressed in adult head. FBgn0040827 Alliance Is expressed in embryonic/larval midgut. FBgn0004244 FlyBase Gene Snapshot "Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior." FBgn0035965 UniProtKB SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion. (UniProtKB:Q9VSU7) FBgn0011206 FlyBase Gene Snapshot boule (bol) encodes a translational regulator required in spermatogenesis for entry into meiosis and spermatid differentiation. It has an additional role in mushroom body gamma neurons as a negative regulator of axon pruning. FBgn0035959 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism. Orthologous to human FBXO33 (F-box protein 33). FBgn0000116 Alliance "Predicted to enable arginine kinase activity and creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Located in cytosol; extracellular region; and plasma membrane. Is expressed in several structures, including adult head; adult heart; brain; embryonic/larval muscle cell; and follicle cell. Orthologous to several human genes including CKMT1A (creatine kinase, mitochondrial 1A); CKMT1B (creatine kinase, mitochondrial 1B); and CKMT2 (creatine kinase, mitochondrial 2)." FBgn0035955 Alliance Is expressed in organism. FBgn0016070 FlyBase Gene Snapshot "smaug (smg) encodes the founding member of the SMAUG family of sequence-specific RNA-binding proteins. During the maternal-to-zygotic transition in early embryos, the smg product inhibits the translation and induces the degradation of hundreds of maternal mRNAs by recruitment of the CCR4-NOT deadenylase complex, thereby controlling embryonic patterning, activation of zygotic transcription, and early embryonic cell cycles." FBgn0035952 Alliance Orthologous to human C22orf23 (chromosome 22 open reading frame 23). FBgn0035948 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0035943 Alliance Predicted to enable polyamine oxidase activity. Is expressed in adult head. Orthologous to human SMOX (spermine oxidase). FBgn0035942 Alliance "Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval muscle system; gastric caecum; and gut section. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial)." FBgn0052029 Alliance "A structural constituent of eye lens. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and embryonic/larval tracheal dorsal trunk." FBgn0035922 Alliance Predicted to enable peroxisome matrix targeting signal-2 binding activity. Involved in protein import into peroxisome matrix. Located in cytosol and peroxisome. Is expressed in embryonic cortex; organism; supraesophageal ganglion; ventral nerve cord; and yolk. Used to study peroxisomal biogenesis disorder. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and rhizomelic chondrodysplasia punctata type 1. Orthologous to human PEX7 (peroxisomal biogenesis factor 7). FBgn0035923 Alliance Predicted to be involved in positive regulation of DNA-templated transcription. Is expressed in spermatozoon. Orthologous to human EDRF1 (erythroid differentiation regulatory factor 1). FBgn0000357 UniProtKB Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment. (UniProtKB:P07184) FBgn0000358 UniProtKB Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment. (UniProtKB:P07186) FBgn0000356 UniProtKB Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment. (UniProtKB:P22977) FBgn0035924 Alliance Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening and regulation of stem cell population maintenance. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. FBgn0052024 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035932 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035933 Alliance Predicted to enable chitin binding activity. Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0052026 Alliance "Predicted to enable isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; dorsal ectoderm; dorsal ectoderm anlage; and embryonic/larval midgut primordium." FBgn0020633 FlyBase Gene Snapshot "Minichromosome maintenance 7 (Mcm7) encodes a component of the MCM2-7 hexamer, which forms part of the CMG complex, together with CDC45L and GINS proteins. CMG complex is the main DNA helicase that functions during DNA replication." FBgn0035934 FlyBase Gene Snapshot "Transient receptor potential cation channel A1 (TrpA1) encodes a cation channel activated by warming and by reactive chemicals. Its roles include the control of thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure." FBgn0035931 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035926 Alliance Predicted to enable long-chain fatty acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in embryonic/larval midgut. FBgn0003149 FlyBase Gene Snapshot "Paramyosin (Prm) encodes a muscle protein found only in invertebrates. It dimerizes into a coiled-coil that occupies the interior of the thick filament. Its role is thought to be structural, although it can be phosphorylated and this is important for muscle function." FBgn0052022 Alliance Involved in oogenesis. Is expressed in adult head; adult heart; and organism. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). FBgn0011509 FlyBase Gene Snapshot Signal recognition particle receptor beta (SrpRbeta) encodes a protein that contributes to cuticle secretion by epidermal cells. FBgn0000121 FlyBase Gene Snapshot Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. FBgn0035921 Alliance Is expressed in embryonic head sensory system; embryonic/larval nervous system; ganglia; mushroom body primordium; and sensory nervous system primordium. FBgn0035875 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0035876 FlyBase Gene Snapshot Peroxin 2 (Pex2) encodes a peroxisome protein important for sperm development. FBgn0011762 FlyBase Gene Snapshot "DNA primase subunit 1 (Prim1) encodes a subunit of the DNA-polymerase alpha complex that, together with the subunit encoded by Prim2, is responsible for primase activity (synthesis of short RNA primers). This activity is required during DNA replication to prime DNA synthesis at origins, and also on the lagging strand during Okazaki fragment synthesis." FBgn0035877 UniProtKB May play a regulatory role in autophagic activity. (UniProtKB:Q9VSH9) FBgn0001253 FlyBase Gene Snapshot Ecdysone-inducible gene E1 (ImpE1) encodes a protein similar to a low-density lipoprotein (LDL) receptor. It is hypothesized to play a role in the cell rearrangements associated with morphogenesis of the disc epithelium. ImpE1 transcription is upregulated by 20-hydroxyecdysone. FBgn0035886 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0035888 Alliance Is expressed in adult head. FBgn0035890 Alliance "Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1)." FBgn0010431 FlyBase Gene Snapshot "matrimony (mtrm) is a haploinsufficient gene expressed solely during oogenesis. While mtrm null females are sterile, heterozygotes are fertile but display high levels of achiasmate chromosome missegregation during meiosis I. The mtrm product binds to and inhibits the kinase encoded by polo in a dosage-dependent manner." FBgn0020224 FlyBase Gene Snapshot "Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation." FBgn0010825 FlyBase Gene Snapshot Grunge (Gug) encodes a nuclear repressor protein that likely responds to Egfr signaling to control cell behavior for normal developmental patterning. FBgn0035901 UniProtKB "Pseudouridylate synthase that catalyzes pseudouridylation of RNAs, such as tRNAs and mRNAs. (UniProtKB:Q9VSK9)" FBgn0035903 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; embryonic head sensory system; embryonic/larval nervous system; and larval ventral nerve cord. FBgn0035904 FlyBase Gene Snapshot Glutathione S transferase O3 (GstO3) encodes a transferase involved in glutathione metabolism. FBgn0024236 UniProtKB "Required for the normal migration of longitudinal and peripheral glial cells. During larval development, required for the migration of the subretinal glia into the eye disk. During embryonic development, also controls the migration of muscle cells toward their attachment sites. Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development. Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis. Acts as a zinc transporter in both yeast and mammalian cells. (UniProtKB:Q9VSL7)" FBgn0035909 Alliance "Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gland; and gut section. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to several human genes including LMAN1 (lectin, mannose binding 1)." FBgn0260442 FlyBase Gene Snapshot "rhea (rhea) encodes fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing shg transcription in follicle cells." FBgn0060292 FlyBase Gene Snapshot C/D box small nucleolar RNA 22a (snoRNA:CD22a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3412 and U3415 in 28SrRNA:CR45844. FBgn0060291 FlyBase Gene Snapshot "C/D box small nucleolar RNA 22b (snoRNA:CD22b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U586 in 18SrRNA:CR45838, and C3412 and U3415 in 28SrRNA:CR45844." FBgn0035914 Alliance Predicted to be active in membrane. FBgn0035915 Alliance Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Located in major mitochondrial derivative. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0052351 Alliance Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0035918 FlyBase Gene Snapshot "Cell division cycle 6 (Cdc6) encodes an essential component of the pre-Replication complex (preRC) together with the origin recognition complex, the product of dup and MCM2-7 proteins. The preRC is present at all chromosomal origins of replication and is required for the initiation of DNA replication. The product of Cdc6 also functions in the co-ordination of DNA replication with mitosis, and may contribute to apoptosis and transcription." FBgn0035916 FlyBase Gene Snapshot "GTPase activating protein, SECIS-dependent read-through (GAPsec) encodes GTPase-activating protein involved in translational readthrough." FBgn0017429 Alliance "Predicted to enable potassium:proton antiporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and potassium ion transmembrane transport. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; longitudinal visceral muscle fiber; and visceral mesoderm derivative. Orthologous to human LETMD1 (LETM1 domain containing 1)." FBgn0017430 FlyBase Gene Snapshot "Negative elongation factor E (Nelf-E) encodes one of four subunits that constitutes the NELF complex, which along with the product of spt4 causes the promoter proximal pause of the RNA polymerase II." FBgn0035911 Alliance Predicted to enable isovaleryl-CoA dehydrogenase activity. Predicted to be involved in L-leucine catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). FBgn0035907 FlyBase Gene Snapshot Glutathione S transferase O1 (GstO1) encodes a transferase involved in glutathione metabolism. FBgn0035906 FlyBase Gene Snapshot Glutathione S transferase O2 (GstO2) encodes a protein involved in glutathione metabolism. FBgn0035902 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism. FBgn0035900 UniProtKB "Required for the export of polyadenylated mRNAs from the nucleu; binds to polyadenylated mRNA, and is involved in the regulation of mRNA polyadenylation. (UniProtKB:Q9VSK8)" FBgn0035896 Alliance "Located in cytosol. Is expressed in several structures, including adult head; adult heart; brain; mesoderm; and synaptic neuropil domain. Orthologous to human ADISSP (adipose secreted signaling protein)." FBgn0052354 Alliance "Predicted to be involved in cell differentiation. Predicted to be active in extracellular region. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic head sensory system; gut section; and head epidermis primordium." FBgn0035889 Alliance Predicted to enable RNA uridylyltransferase activity. Predicted to be involved in RNA 3' uridylation. Is expressed in organism. FBgn0035887 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0001248 FlyBase Gene Snapshot "Isocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, G6pd, and Pgd, in a small network of NADP reducing enzymes." FBgn0035878 Alliance "Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Located in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; gut section; head epidermis primordium; and mesoderm. Orthologous to human HSPA14 (heat shock protein family A (Hsp70) member 14)." FBgn0053057 Alliance "Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Orthologous to human TRPT1 (tRNA phosphotransferase 1)." FBgn0028379 FlyBase Gene Snapshot farinelli (fan) encodes an important protein for sperm development that interacts with the product of Osbp. FBgn0027549 Alliance Predicted to enable DNA-binding transcription factor activity. Involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be part of RQC complex. Is expressed in adult head and organism. Orthologous to human TCF25 (transcription factor 25). FBgn0026252 FlyBase Gene Snapshot "moleskin (msk) encodes an importin that contributes to protein import into the nucleus. It is involved in eye development, muscle attachment and wing cell fate specification." FBgn0035838 UniProtKB Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. (UniProtKB:Q9VSD7) FBgn0010350 FlyBase Gene Snapshot "CDP-diacylglycerol synthase (Cds) encodes an enzyme for the synthesis of cytidine diphosphate diacylglycerol (CDP-DAG) from phosphatidic acid. CDP-DAG is the precursor of two phospholipids, phosphatidylinositol and phosphatidylglycerol. The product of Cds has roles in cell growth and lipid storage." FBgn0002899 FlyBase Gene Snapshot "mutagen-sensitive 301 (mus301) encodes a member of the Mus308 subfamily of ATP-dependent helicases. It is involved in the repair of double-strand DNA breaks during recombination and in somatic cells, and in chromosome segregation. It contributes to dorsal-ventral patterning during oogenesis and posterior oocyte positioning." FBgn0035848 Alliance Predicted to enable NAD+ binding activity and UDP-glucuronate decarboxylase activity. Predicted to be involved in D-xylose metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). FBgn0035850 FlyBase Gene Snapshot Autophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes. FBgn0035851 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9VSF2)" FBgn0035854 UniProtKB Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (UniProtKB:Q9VSF4) FBgn0035856 Alliance Is expressed in organism. FBgn0015793 Alliance "Predicted to enable GTPase activity. Involved in enteroendocrine cell differentiation and regulation of cell differentiation involved in tissue homeostasis. Located in Golgi apparatus; neuronal cell body; and synapse. Is expressed in several structures, including Bolwig organ; adult head; brain; imaginal disc; and synaptic neuropil domain. Orthologous to several human genes including RAB43 (RAB43, member RAS oncogene family)." FBgn0035867 Alliance Is expressed in adult head. Orthologous to human TXNDC11 (thioredoxin domain containing 11). FBgn0035873 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0035872 UniProtKB May play a role in pre-mRNA 3'-processing. (UniProtKB:Q9VSH4) FBgn0035871 UniProtKB "Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (PubMed:19328063). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971). (UniProtKB:Q9VSH3)" FBgn0035870 UniProtKB "Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoidance behavior, probably through sensing 7-tricosene (7-T), a male cuticular pheromone and leading to inhibition of male-male courtship. Finally, also plays a role in oviposition behavior, in which females evaluate their environment and choose to lay eggs on substrates they may find aversive in other contexts. (UniProtKB:Q9VSH2)" FBgn0035868 UniProtKB Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus (By similarity). Does not catalyze the formation of cyclic GMP-AMP from ATP and GTP (PubMed:34261128). (UniProtKB:Q9VSH0) FBgn0035866 FlyBase Gene Snapshot ADP-ribosylation factor-like 5 (Arl5) encodes a protein involved in endosome-to-Golgi trafficking. FBgn0035865 Alliance Is expressed in organism; presumptive wing vein; and wing pouch. FBgn0027569 FlyBase Gene Snapshot ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. FBgn0035858 Alliance Is expressed in adult head. FBgn0052364 FlyBase Gene Snapshot tumorous testis (tut) encodes an RNA-binding protein that forms a complex with the products of bam and bgcn. It is required for the restrained mitotic amplification of germ cells during spermatogenesis. FBgn0035853 UniProtKB Accepts the ubiquitin-like protein Nedd8 from the Uba3-APP-BP1 E1 complex and catalyzes its covalent attachment to other proteins. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. (UniProtKB:Q9VSF3) FBgn0035852 Alliance Predicted to enable heat shock protein binding activity and unfolded protein binding activity. Predicted to be involved in mitochondrion organization and negative regulation of apoptotic process. Predicted to be active in mitochondrion. Is expressed in spermatozoon. FBgn0035849 FlyBase Gene Snapshot "estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages." FBgn0035847 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADGRG4 (adhesion G protein-coupled receptor G4). FBgn0020392 UniProtKB Adds a myristoyl group (tetradecanoyl group) to the N-terminal glycine residue of certain cellular proteins (Probable). Such protein modification are critical for the developmental processes that involve cell shape changes and movement (PubMed:11139338). (UniProtKB:O61613) FBgn0040290 FlyBase Gene Snapshot "RecQ4 helicase (RecQ4) encodes an important protein for genome stability and DNA metabolism. It can utilize energy from ATP hydrolysis to help the DNA strand separation and exchange, playing a critical role in replication and repair." FBgn0035845 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035844 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic/larval tracheal section. FBgn0035842 Alliance Predicted to enable 5'-3' RNA helicase activity; RNA binding activity; and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be active in nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human SETX (senataxin). FBgn0029113 FlyBase Gene Snapshot Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO. FBgn0042112 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL36 (mitochondrial ribosomal protein L36). FBgn0035839 Alliance Predicted to enable cysteamine dioxygenase activity. Orthologous to human ADO (2-aminoethanethiol dioxygenase). FBgn0035833 Alliance Predicted to be involved in neuron migration. Predicted to be active in cytoplasmic vesicle and membrane. Is expressed in adult head; embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and organism. Orthologous to human KIAA0319 (KIAA0319) and KIAA0319L (KIAA0319 like). FBgn0052363 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052362 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052361 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052360 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052359 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052358 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0026263 Alliance Involved in larval lymph gland hemopoiesis. FBgn0035823 FlyBase Gene Snapshot eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation. FBgn0035824 Alliance Is expressed in organism. FBgn0035827 UniProtKB "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with Srp14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of Srp9 and Srp14 is required for SRP RNA binding (By similarity). (UniProtKB:Q9VSC1)" FBgn0041156 FlyBase Gene Snapshot "extra-extra (exex) encodes a homeodomain transcription factor that is expressed in and regulates the differentiation of motor neurons that project axons to ventral body wall muscles. Within the central nervous system, the product of exex negatively interacts with the products of Lim3 and eve to govern neuronal specification and differentiation. The roles of the product of exex include neuronal specification and differentiation." FBgn0035830 Alliance "Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein K48-linked deubiquitination; and negative regulation of protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; ganglia; germline cell; and gonad. Orthologous to human UBXN1 (UBX domain protein 1)." FBgn0011817 FlyBase Gene Snapshot "nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases." FBgn0052370 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035831 Alliance "Predicted to enable rRNA primary transcript binding activity and ribonuclease P RNA binding activity. Predicted to be involved in rRNA processing and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human POP4 (POP4 homolog, ribonuclease P/MRP subunit)." FBgn0035829 FlyBase Gene Snapshot Heterochromatin protein 4 (HP4) encodes a component of classical heterochromatin that is involved in gene silencing by heterochromatin. FBgn0027554 Alliance Predicted to be involved in ERAD pathway. Located in endomembrane system. Is expressed in adult head and adult heart. Used to study candidiasis. Orthologous to human UBXN4 (UBX domain protein 4). FBgn0024187 FlyBase Gene Snapshot sunday driver (syd) encodes a member of a family of scaffolding proteins that bind to JNK and facilitate its activation. syd is an organ size regulator that functions in Hippo signaling and is essential for Diap1 protein stability and function. FBgn0035825 UniProtKB Involved in lipid metabolism and utilization. (UniProtKB:Q9VSB9) FBgn0003041 FlyBase Gene Snapshot "pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation." FBgn0016694 FlyBase Gene Snapshot PAR-domain protein 1 (Pdp1) encodes a member of the PAR domain bZip family of sequence-specific transcription factors. it regulates gene expression in muscles and in circadian clock neurons. FBgn0052369 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in embryonic/larval midgut primordium; embryonic/larval visceral muscle cell; gut section; and longitudinal visceral muscle primordium. Orthologous to several human genes including LONRF1 (LON peptidase N-terminal domain and ring finger 1). FBgn0052371 Alliance Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to be active in microtubule cytoskeleton. FBgn0035789 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in eye disc morphogenetic furrow; leg disc; and wing disc. FBgn0035790 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VS78) FBgn0035793 Alliance Enables enzyme binding activity. Predicted to be involved in ERAD pathway and negative regulation of apoptotic process. Predicted to be located in cytosol. Predicted to be part of BAT3 complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). FBgn0028582 FlyBase Gene Snapshot "liquid facets (lqf) encodes an epsin, which is an endocytic adaptor that contributes to endocytic network stability/regulation and membrane bending. It contributes to endocytosis and regulates the BMP and Notch signaling pathways." FBgn0035798 FlyBase Gene Snapshot faulty attraction (frac) encodes an extracellular matrix protein that acts via an LIMK1- dependent BMP pathway to promote axon target recognition. The product of frac might be a proteolytic substrate of the matrix metalloproteinase encoded by Mmp2. FBgn0035799 FlyBase Gene Snapshot missing minor mitochondria (mmm) encodes a component of the flagellar axoneme that is also involved in the formation or maintenance of the minor mitochondrial derivative during spermatogenesis. It is required for completion of ciliogenesis and results in male sterility with immotile flagella when mutated. FBgn0052373 Alliance Predicted to enable calcium ion binding activity. Involved in synaptic target recognition. Is expressed in Johnston organ. FBgn0035806 FlyBase Gene Snapshot Peptidoglycan recognition protein SD (PGRP-SD) encodes a secreted member of the peptidoglycan recognition protein of from Gram negative bacteria. It is a positive regulator of the Imd pathway by promoting the recognition of peptidoglycan. FBgn0035811 UniProtKB "Medium-chain specific acyl-CoA dehydrogenase that catalyzes the first step of mitochondrial fatty acid beta-oxidation, an aerobic process that breaks down fatty acids into acetyl-CoA and allows the production of energy from fats (PubMed:29563254). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). May contribute to Pink1-mediated regulation of fatty acid and amino acid metabolism, through a mechanism that is independent of its acyl-CoA dehydrogenase activity (PubMed:29563254). (UniProtKB:Q9VSA3)" FBgn0035817 Alliance Predicted to enable unfolded protein binding activity. Involved in protein refolding and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Orthologous to human HSPB6 (heat shock protein family B (small) member 6). FBgn0035815 UniProtKB Plays an olfactory role that is not restricted to pheromone sensitivity. (UniProtKB:E1JI63) FBgn0035813 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Used to study viral infectious disease. FBgn0035812 UniProtKB Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. Specifically recognizes and binds histone H3.1. (UniProtKB:Q9VSA4) FBgn0035805 Alliance Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be active in mitochondrial membrane. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70). FBgn0053276 UniProtKB "Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3 (By similarity). The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U (By similarity). Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Prx2/Jafrac1, Ciao1, Eip71CD and GILT1 (PubMed:26715182, PubMed:28953965). The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates (By similarity). Plays a role in the regulation of JNK signaling in response to oxidative stress (PubMed:26715182). (UniProtKB:Q7KU86)" FBgn0035800 Alliance "Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in centriole and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2)." FBgn0052376 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0052374 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0035795 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0035791 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and photoreceptor neurons. FBgn0015033 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VS79) FBgn0024542 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human NCOA5 (nuclear receptor coactivator 5)." FBgn0016036 FlyBase Gene Snapshot meiotic P22 (mei-P22) encodes a protein thought to form a dimer with the TopoVIA subunit encoded by mei-W68 and is required for meiotic double strand breakes in female meiosis. FBgn0035760 Alliance Is expressed in adult head. FBgn0035762 UniProtKB "During cytokinesis in male meiotic cells, required for completion of cleavage furrow ingression possibly in conjunction with Zw10. Required for maintenance of Golgi stack number and morphology. Essential for acroblast assembly. (UniProtKB:Q9VS46)" FBgn0002909 FlyBase Gene Snapshot "mutagen-sensitive 312 (mus312) is a scaffolding protein that interacts with at least three structure-selective endonucleases (encoded by mei-9-Ercc1, mus81-mms4, and slx1). It is involved in DNA repair and meiotic recombination pathways." FBgn0019662 FlyBase Gene Snapshot "quemao (qm) encodes the ortholog of human geranylgeranyl pyrophosphate synthase (GGPS1), which catalyses protein prenylation and thereby facilitates membrane targeting of proteins. The qm product contributes to heart formation, germ cell migration, and maintenance of plasma membrane integrity in growing oocytes." FBgn0035771 Alliance "Predicted to enable protein transmembrane transporter activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane and post-translational protein targeting to endoplasmic reticulum membrane. Located in fusome. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic hypopharynx; embryonic/larval salivary gland; and gut section. Human ortholog(s) of this gene implicated in polycystic liver disease. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator)." FBgn0082598 UniProtKB "Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is required for embryonic development and for normal innate immune response (PubMed:18066067, PubMed:22396663, PubMed:25180232, PubMed:32950464). Acts as a regulator of embryonic myogenesis by bridging Twist (twi) with the SWI/SNF-like Brahma complex, promoting expression of twi-regulated genes during myogenesis (PubMed:22396663). Effector of immune deficiency pathway (Imd) by acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel) (PubMed:18066067, PubMed:25180232, PubMed:32950464). Acts by bridging the NF-kappa-B factor Rel and the Brahma complex through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes (PubMed:25180232). Not part of the Toll pathway (PubMed:18066067). Required for the formation of the heart by promoting expression ot tinman (tin) (PubMed:32950464). (UniProtKB:Q9VS59)" FBgn0016983 Interactive Fly AAA-protein family - ATPase - Mutants are defective in larval mitoses - expression of Smallminded in cells that undergo late embryonic or larval mitosis suggests a general role in promoting mitosis FBgn0035777 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPA3 (carboxypeptidase A3) and CPB2 (carboxypeptidase B2). FBgn0052379 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). FBgn0035779 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in amnioserosa; embryonic midgut chamber; embryonic/larval midgut interstitial cell; and midgut interstitial cell primordium. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). FBgn0035780 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in larval ventral midline glial cell; larval ventral nerve cord; lateral cord surface glial cell; and ventral midline of embryo. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). FBgn0035785 FlyBase Gene Snapshot "pickpocket 26 (ppk26) encodes a member of the Degenerin/epithelial sodium channel family. In the larva, it regulates locomotion behavior and participates in mechanical nociception together with the product of ppk." FBgn0035786 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0052382 FlyBase Gene Snapshot "sphinx2 (sphinx2) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland." FBgn0052383 FlyBase Gene Snapshot "sphinx1 (sphinx1) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland." FBgn0035782 Alliance Predicted to be involved in sperm DNA condensation. FBgn0014011 FlyBase Gene Snapshot "Rac2 (Rac2) encodes a GTPase signaling protein that acts as a molecular switch, regulating cell shape, movement, division, and wound healing. It responds to signals from RTK and PIP3 pathways, activating the WAVE regulatory complex. This promotes the formation of branched actin filaments, helping cells move and change shape." FBgn0035781 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head; dorsal sensory complex proper primordium; embryonic proventriculus; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). FBgn0035776 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0052380 UniProtKB "A phosphatidylethanolamine (PE)/ceramide ethanolamine phosphotransferase that catalyzes the synthesis of ceramide phosphoethanolamines (CPE), a class of lipids that is a sphingomyelin analog and a major membrane constituent in Drosophila. Transfers the head group from PE (1,2-diacyl-sn-glycero-3-phosphoethanolamine) on to different ceramides such as N-acylsphinganine (dihydroceramide) and N-acyl-(4R)-hydroxysphinganine (phytoceramide) to form N-acyl-sphinganine-1-phosphoethanolamine and N-acyl-(4R)-hydroxysphinganine-1-phosphoethanolamine, respectively. Operates as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum, which is critical for the integrity of the early secretory pathway. (UniProtKB:Q9VS60)" FBgn0035772 Alliance Predicted to be active in cytoplasm. Is expressed in adult brain; adult brain cell body rind; adult heart; and organism. Orthologous to several human genes including SH3BGRL (SH3 domain binding glutamate rich protein like) and SH3BGRL2 (SH3 domain binding glutamate rich protein like 2). FBgn0035770 FlyBase Gene Snapshot pastrel (pst) encodes a protein involved in long-term memory and protein secretion. FBgn0035769 FlyBase Gene Snapshot "CTCF (CTCF) encodes a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to the product of Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture." FBgn0015298 UniProtKB "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of Srp54 to the SRP complex (By similarity). (UniProtKB:P49963)" FBgn0035768 Alliance Is expressed in centripetal follicle cell; egg chamber; and organism. FBgn0035767 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in postsynaptic density membrane. Is expressed in adult head; plasmatocyte primordium; and ventral epidermis primordium. Used to study neuronal ceroid lipofuscinosis 7. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). FBgn0035763 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Is active in Golgi apparatus and endosome. Is expressed in several structures, including adult head; adult heart; amnioserosa; plasmatocyte primordium; and yolk nucleus. Orthologous to human MFSD1 (major facilitator superfamily domain containing 1)." FBgn0035761 Alliance "Enables guanyl-nucleotide exchange factor activity. Involved in cleavage furrow ingression; positive regulation of Rho protein signal transduction; and positive regulation of stress fiber assembly. Located in midbody; mitotic actomyosin contractile ring; and nucleus. Is expressed in several structures, including CNS glial cell; antennal anlage; antennal primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4) and ARHGEF39 (Rho guanine nucleotide exchange factor 39)." FBgn0035756 Alliance Predicted to be active in secretory vesicle. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 3. Orthologous to several human genes including BAIAP3 (BAI1 associated protein 3). FBgn0035755 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic proventriculus inner layer; embryonic ventral epidermis; gland; and gut section." FBgn0035754 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9VS38)" FBgn0012058 FlyBase Gene Snapshot "Cell division cycle 27 (Cdc27) encodes a component of the anaphase-promoting complex/cyclosome (APC/C). It is important for substrate recruitment and interacts with its co-activators, encoded by fzy and fzr, as well as the mitotic checkpoint proteins, encoded by mad2 and BubR1." FBgn0028648 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult heart and organism. Used to study primary ovarian insufficiency. Orthologous to human MRPL50 (mitochondrial ribosomal protein L50). FBgn0035753 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). FBgn0035718 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA5 (carboxypeptidase A5). FBgn0035719 FlyBase Gene Snapshot target of wingless (tow) overexpression and genetic interaction studies suggest that it acts downstream of the products of fz/dsh (Planar Cell Polarity pathway) and upstream of the product of smo (Hedgehog pathway) during development. FBgn0035721 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism. FBgn0029117 FlyBase Gene Snapshot "Surfeit 1 (Surf1) encodes a nuclear gene encoding a protein that might be involved in the assembly of the mitochondrial respiratory chain Cytochrome Oxidase (COX or Complex IV). Mutations in its human ortholog Surf1 are related to Leigh Syndrome with COX deficiency (LScox). Surf1 RNAi knockdown produces many of the hallmark signs of LScox, albeit with a more complex biochemical profile." FBgn0035726 Alliance "Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval garland cell; and mesoderm. Orthologous to human PRSS16 (serine protease 16)." FBgn0035734 Alliance Predicted to enable lysozyme activity. FBgn0035737 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic antennal sense organ; embryonic dorsal epidermis; embryonic maxillary sensory complex; and embryonic ventral epidermis. FBgn0035741 Alliance Predicted to enable patched binding activity and smoothened binding activity. Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of BBSome. Predicted to be active in axoneme and centrosome. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 1. Orthologous to human BBS1 (Bardet-Biedl syndrome 1). FBgn0035743 Alliance Predicted to enable long-chain fatty acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. FBgn0010387 UniProtKB Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters (By similarity). May be involved in energy metabolism in a manner that depends on the substrate used for energy production. Dbi and its metabolites are involved in the regulation of multiple biological processes. (UniProtKB:P42281) FBgn0023001 FlyBase Gene Snapshot melted (melt) encodes an evolutionarily conserved modulator of the insulin/PI3K signaling pathway. It also plays a post-mitotic role in R8 photoreceptor cells in the bistable choice of rhodopsin expression. FBgn0035742 Alliance "Predicted to enable long-chain fatty acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in gastric caecum. Orthologous to human ACBD7 (acyl-CoA binding domain containing 7) and DBI (diazepam binding inhibitor, acyl-CoA binding protein)." FBgn0002775 FlyBase Gene Snapshot "male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable." FBgn0035736 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0035735 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0035733 Alliance Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in signal transduction. Orthologous to several human genes including RASD2 (RASD family member 2). FBgn0001104 UniProtKB "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord. (UniProtKB:P20353)" FBgn0035727 Alliance Is expressed in adult head. FBgn0035725 FlyBase Gene Snapshot Mis12 (Mis12) encodes a protein involved in chromosome movement and metaphase plate congression during mitosis. FBgn0035724 Alliance "Is expressed in several structures, including adult head; embryonic head sensory system; embryonic ventral epidermis; sense organ; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFAP52 (cilia and flagella associated protein 52)." FBgn0035722 Alliance "Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human UQCC1 (ubiquinol-cytochrome c reductase complex assembly factor 1)." FBgn0035720 Alliance "Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Orthologous to several human genes including DDX17 (DEAD-box helicase 17)." FBgn0035711 Alliance Predicted to enable GTP binding activity and GTPase activity. Is expressed in embryonic/larval muscle system and embryonic/larval somatic muscle cell. Orthologous to human RASL11A (RAS like family 11 member A) and RERGL (RERG like). FBgn0035714 Alliance Predicted to enable ribosome binding activity. Involved in cytosolic ribosome assembly. Predicted to be located in nucleolus. Is expressed in adult head. Used to study Shwachman-Diamond syndrome. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome and aplastic anemia. Orthologous to human SBDS (SBDS ribosome maturation factor). FBgn0041194 FlyBase Gene Snapshot "Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes." FBgn0052392 Alliance Involved in axoneme assembly and sperm individualization. Located in cytosol; nucleus; and sperm flagellum. Is expressed in Bolwig organ; chordotonal neurons; embryonic head sensory system; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 32. Orthologous to human RSPH3 (radial spoke head 3). FBgn0035715 Alliance Predicted to be involved in endosome transport via multivesicular body sorting pathway and protein localization. Predicted to be located in endosome. Is expressed in adult head and organism. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). FBgn0035713 FlyBase Gene Snapshot veloren (velo) encodes a SUMO protease that is required for dendrite and axon targeting of olfactory projection neurons. FBgn0005626 FlyBase Gene Snapshot "pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development." FBgn0035710 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic stomatogastric nervous system; embryonic/larval muscle cell; and ganglia." FBgn0041232 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0035709 FlyBase Gene Snapshot eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation. FBgn0035703 UniProtKB "Positive regulator of the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by enhancing its endosomal membrane association (PubMed:32391792, PubMed:32499409). As part of the Mon1-Ccz1 complex involved in endolysosomal biogenesis possibly by mediating Rab conversion, the replacement of Rab5 with Rab7 during late endosome maturation (PubMed:32499409). (UniProtKB:Q9VRX1)" FBgn0020251 UniProtKB "Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling during both embryonic and imaginal disk development. Also required for FGF receptor signaling. (UniProtKB:Q9V3L1)" FBgn0052396 UniProtKB "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. (UniProtKB:Q9VRX3)" FBgn0042185 FlyBase Gene Snapshot "Mitochondrial calcium uniporter (MCU) encodes an inner mitochondrial membrane channel that transports calcium from the mitochondrial intermembrane space to the matrix. It is the main component of the mitochondrial calcium signaling pathway and functions in metabolism, cell death, and olfactory memory." FBgn0035708 Interactive Fly BACK (BTB and C-terminal Kelch) domain protein - a mediator of axon death - axed mutants suppress axon death - acts in glia downstream of sarm - pro-degenerative pathways activated by Sarm signaling or Nmnat elimination ultimately converge on Axed - possibly involved in recruitment of substrates to Cullin Ring Ubiquitin Ligase complexes B FBgn0004619 UniProtKB Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate. (UniProtKB:Q03445) FBgn0024177 UniProtKB Structural component of the gap junctions in germline cells. Required for differentiation and survival of germline cysts in females and of spermatogonia in males; gap junctional communication between spermatogonia and somatic cyst cells may be required for normal differentiation and survival of spermatogonia. (UniProtKB:Q9VRX6) FBgn0002926 FlyBase Gene Snapshot nudel (ndl) encodes a multi-functional protein with serine protease activity. It is required for both eggshell biogenesis and embryonic dorsoventral patterning. FBgn0035704 UniProtKB "Part of the class C core vacuole/endosome tethering (CORVET) complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis by facilitating docking and fusion of endosomal vesicles (PubMed:27253064, PubMed:31194677). The CORVET complex acts upstream of the homotypic fusion and vacuole protein sorting (HOPS) tethering complex but is not involved in autophagic flux (PubMed:27253064, PubMed:31194677). The CORVET complex may cooperate with the early endosomal tether Rbsn-5 to mediate endosomal fusion (PubMed:27253064). As part of the CORVET complex recruited to endosomes by activated GTP-bound Rab5 (PubMed:27253064). Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis (PubMed:27253064). (UniProtKB:Q9VRX2)" FBgn0035702 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human ZBTB48 (zinc finger and BTB domain containing 48). FBgn0020641 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0020642 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic esophagus and embryonic head epidermis. FBgn0020643 UniProtKB Component of the cuticle of the larva. (UniProtKB:C0HL63) FBgn0020644 FlyBase Gene Snapshot Lcp65Ab1 (Lcp65Ab1) encodes a small structural protein of the chitin based larval cuticle. FBgn0020645 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0035686 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0035687 Alliance "Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic stomatogastric nervous system; ganglia; stomatogastric nervous system primordium; and ventral nerve cord primordium. Used to study North Carolina macular dystrophy. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human PRDM13 (PR/SET domain 13)." FBgn0035689 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Is expressed in spermatozoon. Orthologous to human SHPRH (SNF2 histone linker PHD RING helicase). FBgn0035691 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism." FBgn0024921 FlyBase Gene Snapshot Transportin (Tnpo) encodes a protein involved in Hh signalling regulation by mediating the import of the transcription factor encoded by ci into the nucleus. FBgn0035693 Alliance Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). FBgn0041625 FlyBase Gene Snapshot Odorant receptor 65a (Or65a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0035699 Alliance "Is expressed in several structures, including anterior endoderm anlage; clypeo-labral primordium; dorsal epidermis primordium; embryonic dorsal epidermis; and embryonic/larval midgut primordium." FBgn0001258 FlyBase Gene Snapshot Lactate dehydrogenase (Ldh) encodes a protein involved in myoblast fusion and somatic muscle development. FBgn0035697 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0035696 Alliance "Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in peroxisome. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic hindgut; embryonic ventral epidermis; and epithelium. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy; bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3)." FBgn0004513 FlyBase Gene Snapshot Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide. FBgn0035695 Alliance "Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5)." FBgn0035694 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. FBgn0002526 UniProtKB "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth. (UniProtKB:Q00174)" FBgn0035692 UniProtKB "Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (Probable). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (By similarity). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (By similarity). (UniProtKB:Q9VRV7)" FBgn0022935 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; ganglia; gut section; and head epidermis primordium." FBgn0022699 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism." FBgn0035690 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus." FBgn0035688 Alliance Predicted to enable protein phosphatase regulator activity. Involved in negative regulation of JNK cascade. Predicted to be active in cytosol and nucleus. Is expressed in adult head. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). FBgn0035685 Alliance "Is expressed in several structures, including border follicle cell; embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; and embryonic hypopharynx." FBgn0020765 FlyBase Gene Snapshot "Adult cuticle protein 65Aa (Acp65Aa) encodes an adult-specific cuticle protein. Acp65Aa binds chitin and is only found in regions of flexible cuticle such as the abdominal intersegmental membranes, wing hinges and leg joints." FBgn0042118 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in organism. FBgn0052404 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0052405 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; embryonic/larval posterior spiracle; and gut section. FBgn0035641 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in organism. FBgn0035642 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. FBgn0035643 Alliance Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in central brain primordium; dorsal head epidermis anlage in statu nascendi; embryonic brain; larval ventral nerve cord; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to human PRDM8 (PR/SET domain 8) and ZNF488 (zinc finger protein 488). FBgn0035645 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0052409 Alliance "Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal large subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog)." FBgn0035648 Alliance Predicted to be located in membrane. FBgn0052407 Alliance Predicted to enable phosphatidylinositol transfer activity. Predicted to be involved in phospholipid transport. Predicted to be located in endosome. Predicted to be active in endomembrane system and endoplasmic reticulum-endosome membrane contact site. Orthologous to human MOSPD2 (motile sperm domain containing 2). FBgn0052406 FlyBase Gene Snapshot PVR adaptor protein (PVRAP) encodes a protein implicated in VEGF/PDGF signaling. It binds to the product of Pvr and is required for downstream activation of Target of Rapamycin Complex 1. FBgn0040060 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head and embryonic midgut chamber. FBgn0035663 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0035665 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and organism. FBgn0035666 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0028980 FlyBase Gene Snapshot tantalus (tant) encodes a DNA binding protein. It binds to polytene chromosome sites that overlap with the product of Asx. FBgn0035669 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0035673 Alliance Is expressed in adult head. FBgn0035675 Alliance "Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of Lsm1-7-Pat1 complex; spliceosomal complex; and spliceosomal snRNP complex. Is expressed in organism. Orthologous to human LSM5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)." FBgn0035676 Alliance Is expressed in adult head; embryonic brain; embryonic/larval oenocyte; embryonic/larval visceral tracheal branch; and larval ventral nerve cord. Orthologous to several human genes including CYTIP (cytohesin 1 interacting protein). FBgn0035677 Alliance Predicted to enable transcription corepressor activity. Predicted to be involved in DNA-templated transcription. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human SCAI (suppressor of cancer cell invasion). FBgn0061492 FlyBase Gene Snapshot logjam (loj) encodes a p24-transporter-type protein involved in oviposition. FBgn0005658 Interactive Fly "Ets domain transcription factor - regulation of cholinergic cell fate - acts combinatorially to control T1 neuron morphogenesis in the optic lobe, brain and CNS" FBgn0020640 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0020639 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0020638 FlyBase Gene Snapshot Lcp65Ag1 (Lcp65Ag1) encodes a small structural protein of the chitin based larval cuticle. FBgn0020637 UniProtKB Component of the cuticle of the larva. (UniProtKB:C0HL65) FBgn0042119 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0035679 FlyBase Gene Snapshot Galactose mutarotase 2 (Galm2) encodes a putative enzyme that is predicted to catalyze the interconversion of beta-D-galactose and alpha-D-galactose. It is predicted to be involved in galactose metabolism. FBgn0035678 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0035674 Alliance "Predicted to be active in mitochondrion. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and hindgut proper primordium. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial)." FBgn0035670 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0035667 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0035661 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0035657 Alliance Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in testis. FBgn0035656 Alliance "Is expressed in several structures, including anlage in statu nascendi; gland; head epidermis primordium; mesoderm; and visceral mesoderm derivative." FBgn0002638 FlyBase Gene Snapshot "Regulator of chromosome condensation 1 (Rcc1) encodes the guanine-nucleotide exchange factor for the product of Ran. It promotes the nucleo-cytoplasmic shuttling of specific proteins and regulates chromatin condensation. The roles of Rcc1 product include cell proliferation, cell survival, apoptosis, epigenetic regulation, and neuronal specification." FBgn0035649 UniProtKB "Inorganic ion transporter that mediates phosphate ion export across the cell membrane (PubMed:37138087). Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling (PubMed:37138087). The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (By similarity). In enterocytes and differentiating progenitors of the gut, promotes the biogenesis and maintenance of organelles called PXo bodies that store intracellular inorganic phosphate (Pi), and also regulates Cka-JNK mediated tissue homeostasis in response to Pi availability in these tissues (PubMed:37138087). Under conditions of adequate Pi, transports Pi into PXo bodies which convert and store the Pi in the form of phospholipids (PubMed:37138087). It also inhibits Cka at the post-transcriptional level to prevent Cka-bsk/JNK mediated cell proliferation (PubMed:37138087). Upon Pi starvation, Pxo expression is down-regulated resulting in the PXo bodies decreasing in phospholipid content until they undergo lysosomal/autophagosomal degradation and release the stored Pi back into the cytosol for use by the cell (PubMed:37138087). Decrease in Pxo expression also activates the Cka protein, which moves to the nucleus to activate bsk/JNK which then induces nearby progenitor cells to proliferate and form new absorptive cells, probably helping the organism to cope with the nutrient deficiency by maximizing absorption of dietary Pi (PubMed:37138087). (UniProtKB:Q9VRR2)" FBgn0035647 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0052413 Alliance Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Is expressed in adult head. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase) and QPCTL (glutaminyl-peptide cyclotransferase like). FBgn0052412 FlyBase Gene Snapshot Glutaminyl cyclase (QC) encodes a glutaminyl-peptide cyclotransferase involved in peptidyl-pyroglutamic acid biosynthesis. FBgn0035644 FlyBase Gene Snapshot DNA polymerase epsilon subunit 2 (PolE2) encodes a non-catalytic subunit of the major replicative polymerase epsilon. It is involved in the regulation of DNA endoreduplication. FBgn0029121 UniProtKB Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. (UniProtKB:Q9U1H8) FBgn0040239 Alliance Orthologous to human BLCAP (BLCAP apoptosis inducing factor). FBgn0035617 Alliance "Involved in several processes, including autophagic cell death; imaginal disc-derived leg morphogenesis; and response to ecdysone. Predicted to be active in cytoplasm and nucleus. Is expressed in embryonic/larval salivary gland." FBgn0035620 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in embryonic dorsal epidermis; embryonic/larval posterior spiracle; and embryonic/larval tracheal dorsal trunk. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0035623 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0035625 FlyBase Gene Snapshot Blimp-1 (Blimp-1) encodes a zinc finger transcription repressor that is induced by 20-hydroxylecdysone and plays important roles for metamorphosis. It also contributes to embryonic trachea formation. FBgn0035626 Interactive Fly cold shock and RNA-binding protein - regulator of developmental timing - regulator of microRNA maturation FBgn0016756 UniProtKB "Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways (PubMed:10949024, PubMed:18160715, PubMed:26169834, PubMed:27552662). Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway (PubMed:27552662). Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev (PubMed:27552662). Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putative E3 ligases poe, Ufd4 and Kcmf1, which mediate the ubiquitination and proteasomal degradation of rl (PubMed:27552662). During eye development it may also act downstream of rl/MAPK to negatively regulate the Ras/MAPK signaling pathway by stabilizing the transcriptional repressor ttk and consequently inhibiting photoreceptor cell development (PubMed:18160715). This suggests that at least during eye development, it may act in both the positive and negative regulation of the Ras/MAPK signaling pathway to mediate the development of different cell types (PubMed:18160715, PubMed:27552662). Positively regulates border follicle cell migration during oogenesis by mediating the deubiquitination and stabilization of slbo (PubMed:10949024). In the wing disks it positively regulates wg signaling by stabilizing arm (PubMed:26169834). Has an effect on position-effect variegation (PubMed:8816485). (UniProtKB:Q24574)" FBgn0035631 FlyBase Gene Snapshot Thioredoxin-like (Txl) encodes a protein predicted to be involved in the cell redox homeostasis. FBgn0035639 FlyBase Gene Snapshot krishah (kri) encodes a uracil phosphoribosyltransferase. FBgn0035640 FlyBase Gene Snapshot "mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex." FBgn0035638 Alliance Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Predicted to be active in microtubule cytoskeleton. Is expressed in adult head; chordotonal neurons; embryonic head sensory system; male germline cell; and sensory nervous system primordium. Orthologous to human TEKT1 (tektin 1). FBgn0035636 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity and retinal binding activity. Predicted to be located in endosome. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to several human genes including RLBP1 (retinaldehyde binding protein 1). FBgn0040298 UniProtKB "Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins (PubMed:11882391, PubMed:12072468, PubMed:15581871). Mediates phosphorylation of Cdk1 predominantly on 'Thr-14' (PubMed:11882391). Also involved in Golgi fragmentation (PubMed:11882391). May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:11882391). May be a downstream target of Notch signaling pathway during eye development (PubMed:12072468). (UniProtKB:Q9NI63)" FBgn0052418 FlyBase Gene Snapshot "viriato (vito) is a Myc-target gene encoding a nucleolar protein that is required for proper cell and tissue growth. In the developing eye, it is required for correct signal transduction in the cells receiving the product of dpp." FBgn0035632 FlyBase Gene Snapshot Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA. FBgn0035630 Alliance Is expressed in adult head and adult heart. Orthologous to human PA2G4 (proliferation-associated 2G4). FBgn0035627 FlyBase Gene Snapshot "Separase (Sse) encodes an endoprotease. Together with the product of thr, it forms a complex which cleaves a subunit of the cohesin complex during meiosis, thereby allowing separation of the sister chromatids." FBgn0035624 UniProtKB Component of the Enok complex which has a histone H3 acetyltransferase activity (PubMed:27198229). Might be involved in transcriptional activation of selected genes (PubMed:33926075). (UniProtKB:Q9VRN3) FBgn0035622 Alliance Predicted to be involved in protein localization to membrane. Predicted to be active in membrane. Is expressed in adult head; embryonic/larval salivary gland; and organism. Orthologous to human TM9SF3 (transmembrane 9 superfamily member 3). FBgn0035621 Alliance "Is expressed in several structures, including dorsal apodeme anlage; dorsal epidermis primordium; embryonic dorsal apodeme; embryonic dorsal epidermis; and embryonic ventral apodeme." FBgn0035619 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0003486 FlyBase Gene Snapshot "spook (spo) encodes a cytochrome P450 involved in ecdysteroid biosynthesis in the embryo. spo mutants fail to undergo head involution, dorsal closure or to secrete cuticle." FBgn0015766 Alliance "Predicted to be located in membrane. Predicted to be active in nucleolus. Is expressed in several structures, including adult head; anal pad; anal pad primordium; epidermis; and gut section." FBgn0029118 FlyBase Gene Snapshot "Succinyl-coenzyme A synthetase beta subunit, GDP-forming (ScsbetaG) encodes a subunit of the ligase that converts succinate to succinyl-CoA. It is involved in cuticle pigmentation." FBgn0035612 Alliance Predicted to be active in extracellular space. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0035611 Alliance Is expressed in adult head. FBgn0011986 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052420 Alliance Predicted to enable GUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0035600 Alliance "Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1)." FBgn0035607 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0035610 FlyBase Gene Snapshot "Leucokinin receptor (Lkr) encodes a 7-transmembrane domain G-protein-coupled receptor (GPCR) with the product of Lk as a ligand. It signals through intracellular calcium, and is implicated in ion regulation by the Malpighian tubules and in feeding control." FBgn0035608 FlyBase Gene Snapshot blanks (blanks) encodes a nuclear siRNA binding protein expressed in spermatocytes. It contributes to sperm individualization and chromatin silencing regulation. FBgn0035604 FlyBase Gene Snapshot Ionotropic receptor 64a (Ir64a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It is part of a broad-specificity acid sensor that mediates avoidance behavior. FBgn0035603 UniProtKB Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). (UniProtKB:Q9VRL3) FBgn0035601 FlyBase Gene Snapshot "Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion." FBgn0004380 FlyBase Gene Snapshot Kinesin-like protein at 64D (Klp64D) encodes the kinesin-2alpha motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp68D and Kap3. It plays an essential role in sensory cilia assembly and axonal transport. FBgn0052421 Alliance Predicted to enable GUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0016031 UniProtKB Putative phospholipase (By similarity). Involved in the regulation of cellular plasticity in imaginal disks. (UniProtKB:Q9VRK8) FBgn0040842 Alliance Is expressed in embryonic dorsal epidermis; embryonic esophagus; embryonic head epidermis; and embryonic ventral epidermis. FBgn0035593 UniProtKB Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Involved in the regulation of DNA damage repair (PubMed:35393473). (UniProtKB:Q9VRJ9) FBgn0035591 Alliance Predicted to enable tRNA binding activity. Predicted to be involved in tRNA 3'-end processing. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human PTCD1 (pentatricopeptide repeat domain 1). FBgn0035589 FlyBase Gene Snapshot Charged multivesicular body protein 2b (CHMP2B) encodes an ESCRT-III component. It plays an important role in the generation of multivesicular bodies in the endosomal lysosomal pathway. It is also considered to play an important role in autophagosome maturation. FBgn0035587 FlyBase Gene Snapshot "Gdap1 (Gdap1) encodes a transmembrane protein of the outer mitochondrial membrane. Dysregulation of Gdap1 expression has been related to mitochondrial dynamics, oxidative stress and neuromuscular degeneration." FBgn0028962 UniProtKB Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (UniProtKB:Q9VRJ1) FBgn0010747 Alliance "Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Is expressed in adult head; presumptive embryonic salivary gland; and salivary gland body primordium. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54)." FBgn0035598 FlyBase Gene Snapshot "CG4669 encodes a protein which contains two copies of a VTD-type deubiquitinase domain. It is most likely inactive, since crucial active site residues are missing." FBgn0035586 UniProtKB "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:28067622). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity) (PubMed:28067622). Required for correct morphology of nociceptive multi-dendritic sensory neurons (PubMed:28067622). Required for normal mechanical amplification in hearing (PubMed:28067622). (UniProtKB:Q9VRJ2)" FBgn0035588 Alliance Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be located in peroxisome. Is expressed in adult head; adult heart; embryonic midgut chamber; embryonic/larval midgut; and organism. Orthologous to several human genes including DHRS2 (dehydrogenase/reductase 2) and DHRS4 (dehydrogenase/reductase 4). FBgn0035590 FlyBase Gene Snapshot "Threonyl-carbamoyl synthesis 5 (Tcs5) encodes an atypical Ser/Thr kinase part of the KEOPS/EKC complex. It phosphorylates the product of p53 and is regulated by the products of Akt and Rab35. It is involved in tRNAs modification, telomere and chromatin dynamics." FBgn0035592 Alliance Predicted to enable protein folding chaperone. Predicted to be involved in protein insertion into ER membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human WDR83OS (WD repeat domain 83 opposite strand). FBgn0052523 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in photoreceptor neurons. FBgn0011954 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031169 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0020369 FlyBase Gene Snapshot "Regulatory particle triple-A ATPase 6 (Rpt6) encodes a subunit of the proteasome, which is responsible for the ATP-dependent degradation of obsolete or damaged proteins. Rpt6 product belongs to the heterohexameric ring formed by triple-A ATPases that unfolds ubiquitinated target proteins before their degradation." FBgn0031174 Alliance "Predicted to enable carbon-carbon lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic proventriculus; embryonic ventral epidermis; and gland. Orthologous to several human genes including PDXDC1 (pyridoxal dependent decarboxylase domain containing 1)." FBgn0000709 UniProtKB "May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development. (UniProtKB:Q24020)" FBgn0015379 Interactive Fly "peptidylprolyl isomerase - facilitates the degradation of the transcription factor CF2, which regulates expression of the rhomboid gene in follicle cells" FBgn0011710 FlyBase Gene Snapshot "Septin 1 (Septin1) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that associate with filamentous actin. Septin1, together with Septin5 and pnut, is required for the bundling of actin filaments into compact cytoskeleton cables during dorsoventral wing adhesion." FBgn0003423 UniProtKB "Converts proline to delta-1-pyrroline-5-carboxylate (PubMed:8096642). Involved in the conversion of proline to glutamate, which functions as a transmitter at neuromuscular junctions (PubMed:8096642). Glutamate deficiency could possibly account for reduced motor activity (PubMed:8096642). (UniProtKB:Q04499)" FBgn0020272 FlyBase Gene Snapshot misato (mst) encodes a conserved protein that acts as a co-factor of the TCP-1 tubulin chaperone complex. It is required for mitotic spindle assembly and viability and for tubulin polymerization and stability. FBgn0031182 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VRI9) FBgn0031181 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult abdominal segment; gustatory receptor neurons; labral sense organ neurons; and tarsal segment 5. FBgn0031178 Alliance Predicted to be located in extracellular space. FBgn0028583 Alliance Is expressed in midline primordium. FBgn0001565 Alliance Predicted to enable RNA helicase activity. Involved in defense response to virus. Predicted to be located in cytosol. Predicted to be active in nucleolus. Is expressed in brain; embryonic/larval fat body; embryonic/larval salivary gland; imaginal disc; and ovary. Orthologous to human DDX56 (DEAD-box helicase 56). FBgn0025882 FlyBase Gene Snapshot C/D box small nucleolar RNA 10 (snoRNA:CD10) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation in U6 snRNA. FBgn0015527 Alliance "Predicted to enable mRNA binding activity. Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. Predicted to be active in nucleolus. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human PUM3 (pumilio RNA binding family member 3)." FBgn0015558 UniProtKB Non-essential protein that probably acts as a chloride channel. (UniProtKB:Q9U6L4) FBgn0029067 FlyBase Gene Snapshot CTD nuclear envelope phosphatase 1 (Ctdnep1) encodes a putative protein phosphatase of the Haloacid Dehalogenase family. It has a negative effect on BMP signaling-dependent wing vein formation. FBgn0031171 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0031170 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head and organism. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). FBgn0052521 Alliance Involved in positive regulation of Notch signaling pathway. Located in plasma membrane. Is expressed in adult head. FBgn0031145 FlyBase Gene Snapshot Nuclear transport factor-2 (Ntf-2) is an essential gene regulating nuclear import. It encodes a protein that binds to the nuclear pore protein encoded by DCTN4-p62 and to the product of Ran and regulates the nuclear import of nuclear localization signal containing proteins. FBgn0025814 Alliance "Predicted to enable glutathione peroxidase activity; glutathione transferase activity; and prostaglandin-E synthase activity. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including adult head; adult heart; antenno-maxillary complex; germline cell; and gut section. Orthologous to several human genes including MGST1 (microsomal glutathione S-transferase 1)." FBgn0031148 FlyBase Gene Snapshot Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response. FBgn0031150 Alliance "Predicted to enable cAMP binding activity. Predicted to be involved in several processes, including cell-cell adhesion; heart development; and striated muscle cell differentiation. Predicted to be located in membrane. Predicted to be active in sarcolemma. Is expressed in adult head; follicle cell; and nurse cell. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy and autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to several human genes including BVES (blood vessel epicardial substance)." FBgn0031161 Alliance Predicted to be involved in regulation of ubiquitin-dependent protein catabolic process. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). FBgn0031164 Alliance Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in positive regulation of protein processing and protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A) and TIMM17B (translocase of inner mitochondrial membrane 17B). FBgn0031157 Alliance "Predicted to be involved in proteolysis. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific)." FBgn0031155 Alliance Is expressed in gonad. FBgn0052512 Alliance Is expressed in adult fat body; adult head; and organism. Orthologous to human TMEM205 (transmembrane protein 205). FBgn0031149 Alliance Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Located in endomembrane system. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A). FBgn0031146 Alliance Predicted to be involved in septate junction assembly. Predicted to be active in plasma membrane. FBgn0031144 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; hindgut proper primordium; and mesoderm." FBgn0031143 Alliance Is expressed in adult head; embryonic esophagus; embryonic proventriculus; and organism. Orthologous to human GLOD4 (glyoxalase domain containing 4). FBgn0031142 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0031141 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0011834 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0031132 Alliance Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Orthologous to human GPAT3 (glycerol-3-phosphate acyltransferase 3) and GPAT4 (glycerol-3-phosphate acyltransferase 4). FBgn0031101 Alliance "Is expressed in several structures, including antenno-maxillary complex; embryonic/larval brain; female germline cell; imaginal disc; and main body follicle cell." FBgn0027334 Alliance "Predicted to enable RNA binding activity. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Orthologous to human PNO1 (partner of NOB1 homolog)." FBgn0031107 UniProtKB Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (UniProtKB:Q9VR91) FBgn0031109 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q9VR94) FBgn0031110 Alliance Enables amino acid binding activity. Involved in sensory perception of taste. Predicted to be located in extracellular region. Is expressed in anterior wing margin; labellum; and leg taste bristle. FBgn0011280 Alliance "Predicted to enable pheromone binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in several structures, including eo sensory organ accessory cell; labellum; organism subdivision; pseudotrachea; and sense organ." FBgn0031114 FlyBase Gene Snapshot "cactin (cactin) encodes a conserved protein that functions in the Rel-NFkB pathway, possibly by controlling the stability of the product of cact." FBgn0002641 UniProtKB Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (UniProtKB:Q9VRA2) FBgn0031116 Alliance Predicted to enable GTPase activator activity. Orthologous to human SGSM1 (small G protein signaling modulator 1) and SGSM2 (small G protein signaling modulator 2). FBgn0052506 Alliance Predicted to enable GTPase activator activity. Involved in protein secretion. Located in endoplasmic reticulum exit site. Orthologous to human SGSM1 (small G protein signaling modulator 1) and SGSM2 (small G protein signaling modulator 2). FBgn0031117 FlyBase Gene Snapshot Glutathione S transferase T3 (GstT3) encodes an enzyme involved in glutathione metabolic processes. FBgn0031119 Alliance Predicted to be located in cytosol. Is expressed in organism and pole plasm. Orthologous to human KLHL26 (kelch like family member 26). FBgn0026323 FlyBase Gene Snapshot "TGF-beta activated kinase 1 (Tak1) encodes a MAP kinase kinase kinase that functions downstream of the products of imd, Fadd and Diap2. It also functions upstream of the IKK complex in the Imd pathway, a pathway regulating the antibacterial response and other less characterized cellular processes. Upon activation the product of imd, the product of Tak1 can also activate the JNK pathway at the level of the JNK Kinase encoded by bsk in certain cell types. It is also an intracellular signaling component of the Grindelwald-Eiger pathway." FBgn0031118 Interactive Fly "the only high-probability Cdc42GAP required for polarity in the follicular epithelium - recruited by α-catenin to lateral E-cadherin adhesion complexes, resulting in exclusion of active Cdc42 from the lateral domain - couples lateral cadherin adhesion to the apical localization of active Cdc42, thereby suppressing epithelial invasion - controls Rac and Rho GTPases during the dorsal closure and genetically regulates the elmo-mbc complex - RhoGAP19D-depleted embryos displayed complex epidermal cell phenotypes (a fragmented actomyosin cable, bimodal leading-edge tensions, transient Rac and lamellipodia states, and cadherin height defects)" FBgn0040650 Alliance Predicted to be involved in negative regulation of apoptotic process and positive regulation of filopodium assembly. Predicted to be active in cytosol. Orthologous to human MIEN1 (migration and invasion enhancer 1). FBgn0023177 UniProtKB Protein phosphatase that regulates many processes such as microtubule organization at centrosomes. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase-induced cell death (in vitro). (UniProtKB:O76932) FBgn0031111 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in adult labral sense organ; dorsal cibarial sense organ; embryonic antennal sense organ; and ventral cibarial sense organ. FBgn0040651 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria. (UniProtKB:Q9VR93)" FBgn0031108 Alliance Predicted to be part of mitochondrial proton-transporting ATP synthase complex. FBgn0031106 FlyBase Gene Snapshot Syntaxin 16 (Syx16) encodes a member of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. It is localized to late Golgi compartments and is part of a trans-SNARE complex responsible for endosome-to-Golgi/trans Golgi network retrograde transport. FBgn0031104 Alliance Involved in pupation. FBgn0031100 Alliance Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be part of voltage-gated potassium channel complex. FBgn0027107 UniProtKB Structural components of the gap junctions. (UniProtKB:Q9VR82) FBgn0031183 UniProtKB Putative transporter. (UniProtKB:Q9VR50) FBgn0014395 FlyBase Gene Snapshot "touch insensitive larva B (tilB) encodes a protein required for the assembly and/or transport to the cilium of axonemal dynein arms. tilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. It interacts with the product of Zmynd10, which has a similar distribution and mutant phenotype." FBgn0031187 UniProtKB Hydrolase that deubiquitinates polyubiquitinated target proteins (PubMed:25027767). Required for preventing the activation of the Toll signaling cascades under unchallenged conditions (PubMed:25027767). Essential for bodily calcium homeostasis (PubMed:26756164). (UniProtKB:Q8IQ27) FBgn0031189 UniProtKB S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. (UniProtKB:Q9VR56) FBgn0027279 UniProtKB "Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. (UniProtKB:Q9VR59)" FBgn0052499 Alliance "Predicted to enable chitin binding activity. Predicted to be involved in carbohydrate metabolic process. Located in perivitelline space. Is expressed in several structures, including adult brain cell body rind; embryonic head epidermis; embryonic ventral epidermis; epithelium; and gut section." FBgn0031190 Alliance "Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; ganglia; gut section; and mesoderm." FBgn0031188 Alliance Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human FAM210A (family with sequence similarity 210 member A). FBgn0031184 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in adult head; embryonic/larval oenocyte; larval ventral nerve cord; and organism." FBgn0031617 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0031621 FlyBase Gene Snapshot Early boundary activity 3 (Elba3) encodes a chromatin boundary factor involved in the regulation of chromatin silencing. FBgn0031628 Alliance "Predicted to enable mRNA binding activity and pre-mRNA 3'-splice site binding activity. Involved in wound healing. Predicted to be part of U12-type spliceosomal complex and U2AF complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human ZRSR2P1 (ZRSR2 pseudogene 1) and ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2)." FBgn0031630 Alliance Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be active in lipid droplet. Is expressed in adult fat body; adult head; embryonic anal pad; and embryonic large intestine. Orthologous to several human genes including SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). FBgn0031632 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and foregut primordium." FBgn0031636 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in lysosome and membrane. Is expressed in adult head and organism. Orthologous to human MFSD1 (major facilitator superfamily domain containing 1). FBgn0031638 Alliance Is expressed in organism. FBgn0031640 FlyBase Gene Snapshot "Monensin sensitivity 1 (Mon1) encodes a protein that forms a complex with the product of Ccz1 and acts as an exchange factor of the small G-protein encoded by Rab7. It activates and recruits the product of Rab7 to the maturing endosome, inducing the fusion of the matured endosome with the lysosome. Mon1/Ccz1 complex loss of function results in Rab7 phenotypes." FBgn0051660 FlyBase Gene Snapshot smog (smog) encodes a G-protein-coupled receptor with a key role in gastrulation. It contributes to cell intercalation and apical constriction via myosin II activation. FBgn0031643 Alliance "Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in cytoplasm and nucleus. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; ganglia; germline cell; and mesoderm. Orthologous to human RIOK3 (RIO kinase 3)." FBgn0031639 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head; embryonic/larval midgut; and organism. Used to study intrinsic cardiomyopathy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 36. Orthologous to human MRPS2 (mitochondrial ribosomal protein S2). FBgn0031635 FlyBase Gene Snapshot tank (tank) encodes the homolog of tumor suppressor EI24/PIG8. It regulates ethanol sedation sensitivity. FBgn0031634 FlyBase Gene Snapshot Ionotropic receptor 25a (Ir25a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as co-receptor subunit in chemosensation and thermosensation. FBgn0031633 Alliance "Predicted to enable protein prenyltransferase activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity and protein farnesyltransferase activity. Involved in positive regulation of Ras protein signal transduction. Predicted to be part of CAAX-protein geranylgeranyltransferase complex and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha)." FBgn0031631 Alliance "Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human DHX35 (DEAH-box helicase 35)." FBgn0031627 Alliance "Involved in male courtship behavior, veined wing generated song production. Predicted to be active in neuron projection. Is expressed in adult head." FBgn0031622 Alliance Predicted to enable deubiquitinase activity and serine-type peptidase activity. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to several human genes including OTUD4 (OTU deubiquitinase 4). FBgn0000227 UniProtKB The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity (PubMed:23240086). Elba1 may act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495). (UniProtKB:Q9VR17) FBgn0028482 FlyBase Gene Snapshot borderless (bdl) encodes a cell adhesion molecule that is required for glial extension and axon ensheathment. Its down-regulation by the products of tutl and Lar is required for photoreceptor axonal tiling and layer-specific target selection. FBgn0020762 FlyBase Gene Snapshot ABC transporter expressed in trachea (Atet) encodes a protein that is involved in transmembrane transport. FBgn0031596 Alliance Orthologous to human CYB5D1 (cytochrome b5 domain containing 1). FBgn0026319 FlyBase Gene Snapshot "TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth." FBgn0027560 FlyBase Gene Snapshot Trehalose-6-phosphate synthase 1 (Tps1) encodes the trehalose synthesis enzyme with an N-terminal trehalose-6-phosphate (T6P) synthase domain that catalyzes the production of T6P using glucose-6-phosphate and UDP-glucose. Its C-terminal T6P phosphatase domain dephosphorylates T6P to generate trehalose. FBgn0022153 Alliance Is expressed in adult head; embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human TMEM94 (transmembrane protein 94). FBgn0031601 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism. Human ortholog(s) of this gene implicated in Burn-McKeown syndrome. Orthologous to human TXNL4A (thioredoxin like 4A)." FBgn0031603 Alliance Predicted to enable RNA binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human FAM32A (family with sequence similarity 32 member A). FBgn0031604 FlyBase Gene Snapshot "Elongator complex protein 3 (Elp3) encodes a Lysine (K) acetyltransferase (KAT) that resides primarily in the cytoplasm of neurons. It acetylates the product of brp in an opposite reaction to the product of HDAC6 to regulate T-bar morphology and function, and unlike most KATs it does not acetylate histones." FBgn0040705 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 13. Orthologous to human NDUFA2 (NADH:ubiquinone oxidoreductase subunit A2). FBgn0031608 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. FBgn0031610 UniProtKB "Transcription repressor that inhibits transcription of srl/PGC-1-alpha to negatively regulate mitochondrial biogenesis and thereby promotes neurodegeneration (PubMed:27819722, PubMed:32138754). In neurons, functions downstream of the Pink1-park pathway and is likely to act as part of the Pink1-park homeostatic mechanism that maintains mitochondrial quality and function through degradation (mitophagy) and synthesis (biogenesis) (PubMed:32138754). (UniProtKB:Q9VR05)" FBgn0031611 Alliance "Predicted to enable phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity. Involved in regulation of lysosome organization. Predicted to be located in endosome membrane. Predicted to be part of PAS complex. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in organism. Used to study Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 4J; amyotrophic lateral sclerosis type 11; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase)." FBgn0031613 FlyBase Gene Snapshot Heterochromatin protein 6 (HP6) encodes a chromo shadow domain protein involved in telomere capping. FBgn0011603 FlyBase Gene Snapshot "inebriated (ine) encodes a protein that belongs to the SLC6A family of neurotransmitter transporters. It is involved in the control of photoreceptor potential, perineurial glial growth and the osmotic stress response. It also acts in the peripheral glia to control motor neuron excitability in third instar larvae." FBgn0031609 Alliance Orthologous to human TMCO6 (transmembrane and coiled-coil domains 6). FBgn0053002 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human MRPL27 (mitochondrial ribosomal protein L27)." FBgn0019982 UniProtKB "Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. (UniProtKB:Q94529)" FBgn0031607 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition. Predicted to be active in cytosol. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). FBgn0031606 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in organism. Orthologous to human PHF14 (PHD finger protein 14). FBgn0025684 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in ATP transport. Is expressed in adult head. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human SLC17A9 (solute carrier family 17 member 9). FBgn0027609 FlyBase Gene Snapshot "modifier of rpr and grim, ubiquitously expressed (morgue) encodes an F box/ubiquitin conjugase domain protein. It regulates cell death by controlling the levels of the apoptosis inhibitor encoded by Diap1." FBgn0051963 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031600 Alliance Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in trans-Golgi network. Is expressed in adult head. Orthologous to human YIPF6 (Yip1 domain family member 6). FBgn0031598 FlyBase Gene Snapshot Vacuolar protein sorting 53 (Vps53) encodes a predicted component of the Golgi-Associated Retrograde Protein (GARP) complex. It is important for secretory granule maturation and for preventing early degradation of these granules. FBgn0031597 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. FBgn0000547 FlyBase Gene Snapshot "echinoid (ed) encodes a cell adhesion molecule of adherens junctions that mediate cell adhesion/recognition. It participates in multiple signaling pathways including Egfr, Notch and Hippo during organogenesis. It is also required in multiple steps of dorsal closure during embryogenesis." FBgn0020376 Alliance Predicted to be involved in nervous system development. Predicted to be located in membrane. FBgn0014033 Alliance Enables scavenger receptor activity. Involved in endocytosis. Located in plasma membrane. Is expressed in adult head; embryonic/larval hemocyte; embryonic/larval plasmatocyte; head mesoderm; and plasmatocyte primordium. FBgn0031585 Alliance Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to be active in microtubule cytoskeleton. FBgn0040102 FlyBase Gene Snapshot lectin-24Db (lectin-24Db) encodes a protein that interacts specifically with fucose and mannose. FBgn0003941 Alliance "Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Part of cytosolic large ribosomal subunit. Is expressed in several structures, including adult heart; embryonic/larval fat body; embryonic/larval hindgut; embryonic/larval salivary gland; and germinal proliferation center. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1)." FBgn0031592 Alliance Predicted to enable histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in organism and ovary. FBgn0031590 Alliance Located in endomembrane system. Is expressed in adult head and organism. Orthologous to human CLPTM1 (CLPTM1 regulator of GABA type A receptor forward trafficking). FBgn0001075 FlyBase Gene Snapshot fat (ft) is a tumor suppressor gene that encodes a large cadherin family transmembrane protein. It functions in the Hippo signaling pathway (as a receptor) and the Dachsous-Fat planar cell polarity pathway (as a transmembrane component). FBgn0031589 UniProtKB "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. (UniProtKB:Q9VQX4)" FBgn0026394 FlyBase Gene Snapshot Odorant receptor 24a (Or24a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0031568 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in plasma membrane. FBgn0004893 FlyBase Gene Snapshot brother of odd with entrails limited (bowl) encodes a member of the Odd-skipped (Odd) family of zinc finger proteins involved in developmental patterning and cell fate specification. Its localization in the nucleus is regulated by the nuclear protein encoded by lin and the the product of drm with opposing roles. FBgn0051960 Alliance Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. FBgn0031571 FlyBase Gene Snapshot bark beetle (bark) encodes a putative transmembrane scavenger receptor-like protein that is essential for the maturation of septate junctions (SJ). Loss of bark produces cell adhesion defects and mislocalization of SJ core complexes. FBgn0021800 FlyBase Gene Snapshot Regulator of eph expression (Reph) encodes a putative nuclear protein involved in visual system development via the regulation of the product of Eph. FBgn0003430 FlyBase Gene Snapshot "sloppy paired 1 (slp1) encodes a transcription factor of the fork-head family that functions by interacting with the corepressor encoded by gro. The product of slp1 regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons." FBgn0004567 FlyBase Gene Snapshot "sloppy paired 2 (slp2) encodes a transcription factor of the fork-head family. Together with the product of slp1, it regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons." FBgn0031574 Alliance "Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cilium. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval nervous system; and ganglia. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4)." FBgn0051774 FlyBase Gene Snapshot friend of echinoid (fred) encodes a protein involved in cuticle biosynthesis and ommatidial rotation. FBgn0051773 Alliance Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to be active in cytosol and mitochondrion. Orthologous to human FPGS (folylpolyglutamate synthase). FBgn0000256 FlyBase Gene Snapshot cappuccino (capu) encodes a formin family protein that nucleates actin filaments and accelerates their elongation. It works with the product of spir to build an actin mesh that fills the oocyte during mid-oogenesis. capu is necessary for polarity establishment and female fertility. FBgn0051957 Alliance Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be active in nucleus. Orthologous to human EIF1AD (eukaryotic translation initiation factor 1A domain containing). FBgn0031573 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism." FBgn0031533 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0031534 Alliance "Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in early endosome to Golgi transport. Predicted to be part of retromer, tubulation complex. Predicted to be active in endosome membrane. Is expressed in several structures, including adult head; adult heart; ganglia; germline cell; and gut section. Orthologous to human SNX1 (sorting nexin 1) and SNX2 (sorting nexin 2)." FBgn0031535 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to be active in endoplasmic reticulum. Is expressed in organism. Orthologous to several human genes including ZFAND2B (zinc finger AN1-type containing 2B). FBgn0021967 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 35. Orthologous to human NDUFB10 (NADH:ubiquinone oxidoreductase subunit B10)." FBgn0051776 UniProtKB "May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. (UniProtKB:Q8IA43)" FBgn0051956 FlyBase Gene Snapshot Polypeptide N-Acetylgalactosaminyltransferase 4 (Pgant4) encodes a member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family. It catalyzes the transfer of a GalNAc sugar onto the hydroxyl groups of serine and threonine in secreted or membrane-bound proteins. It is essential and is involved in secretory vesicle formation by protecting the cargo receptor encoded by Tango1 from the proteolysis mediated by the product of Fur1. FBgn0031544 Alliance "Predicted to enable calcium ion binding activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis. Located in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human CCDC47 (coiled-coil domain containing 47)." FBgn0031546 Alliance Predicted to be involved in regulation of cilium assembly. Predicted to be active in centrosome. Orthologous to human ODF2 (outer dense fiber of sperm tails 2). FBgn0031550 UniProtKB Required for the formation of cilia. (UniProtKB:Q9VQS5) FBgn0024244 FlyBase Gene Snapshot drumstick (drm) encodes a member of the Odd-skipped (Odd) family of zinc finger proteins involved in developmental patterning and cell fate specification. It stabilizes the related Odd family protein encoded by bowl in the nucleus by outcompeting the binding of the nuclear protein encoded by lin to the product of bowl and localizing the product of lin to the cytoplasm. FBgn0015663 FlyBase Gene Snapshot "UDP-glycosyltransferase family 36 member A1 (Ugt36A1) encodes a member of the superfamily of UDP glycosyltransferase enzymes, which are found across all kingdoms and are involved in detoxification of endogenous and xenobiotic compounds." FBgn0031564 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0031566 Alliance "Predicted to enable glycerophosphocholine phosphodiesterase activity. Predicted to be involved in glycerophospholipid catabolic process. Is expressed in several structures, including dorsal ectoderm; dorsal head epidermis anlage; embryonic head epidermis; embryonic head sensory system; and hindgut anlage. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1)." FBgn0040104 Alliance Predicted to enable galactose binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules and induction of bacterial agglutination. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in 3MC syndrome 3; asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to several human genes including COLEC10 (collectin subfamily member 10); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). FBgn0015376 UniProtKB "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA and has weak ATPase activity. The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. (UniProtKB:Q8IQ05)" FBgn0051777 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0051778 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0031563 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. FBgn0031562 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in embryonic large intestine. FBgn0031561 FlyBase Gene Snapshot Immune induced molecule 33 (IM33) encodes a protein that belongs to a class of small secreted peptides released in the hemolymph upon systemic microbial infection. FBgn0031560 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor). FBgn0051779 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor). FBgn0031559 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0031558 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0031554 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. FBgn0002985 UniProtKB "Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions. May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation. (UniProtKB:P23803)" FBgn0004892 UniProtKB "Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions (By similarity). May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation. (UniProtKB:Q9VQS7)" FBgn0031549 FlyBase Gene Snapshot Spindly (Spindly) encodes a key regulator of dynein recruitment to kinetochores and is involved in the spindle assembly checkpoint during the cell cycle. It also contributes to cell morphology and migration. FBgn0031547 Alliance Predicted to be involved in nervous system development. Predicted to be located in membrane. FBgn0031545 Alliance Predicted to be involved in regulation of cilium assembly. Predicted to be active in centrosome. Is expressed in adult head and spermatozoon. FBgn0051954 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). FBgn0031540 Alliance Predicted to enable 5'-3' DNA helicase activity. Involved in double-strand break repair via break-induced replication. Predicted to be active in replication fork. Is expressed in organism. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). FBgn0005616 FlyBase Gene Snapshot "male-specific lethal 2 (msl-2) encodes the key male-specific subunit of the male-specific-lethal dosage compensation complex. It induces or stabilizes all other components. Homozygous mutant males die, while msl-2 ectopic expression kills females." FBgn0031538 Alliance Predicted to enable lipid binding activity. Is expressed in adult head; amnioserosa; embryonic/larval fat body; organism; and yolk nucleus. FBgn0014906 FlyBase Gene Snapshot alpha/beta hydrolase2 (Hydr2) encodes a lipase involved in lipid metabolism. FBgn0011985 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031513 Alliance Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be part of Set1C/COMPASS complex. FBgn0031517 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0031520 Alliance Predicted to enable sugar transmembrane transporter activity. Predicted to be involved in carbohydrate transport and transmembrane transport. Predicted to be located in membrane. FBgn0053281 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; embryonic Malpighian tubule; and embryonic main segment of Malpighian tubule. FBgn0053282 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0031522 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in embryonic Malpighian tubule. FBgn0031523 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. FBgn0016698 FlyBase Gene Snapshot Phosphotyrosyl phosphatase activator (Ptpa) encodes a nuclear protein that associates with the catalytic subunit of the PP4 complex encoded by Pp4-19C in larval brain neuroblasts. It facilitates the dephosphorylation and basal distribution of the mira protein during neuroblast asymmetric division. FBgn0031529 UniProtKB "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. (UniProtKB:Q9VQP9)" FBgn0031528 Alliance "Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to several human genes including FBXL17 (F-box and leucine rich repeat protein 17); FBXL18 (F-box and leucine rich repeat protein 18); and FBXL21P (F-box and leucine rich repeat protein 21, pseudogene)." FBgn0031519 Alliance "Enables microtubule severing ATPase activity. Involved in several processes, including microtubule severing; mitotic sister chromatid segregation; and regulation of microtubule depolymerization. Located in centrosome and chromosome. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to several human genes including FIGNL1 (fidgetin like 1)." FBgn0031516 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; dorsal pharyngeal muscle primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4)." FBgn0031514 Alliance Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be active in membrane. Is expressed in embryonic anal pad; embryonic large intestine; and embryonic rectum. Orthologous to human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3). FBgn0011984 Alliance Predicted to enable UCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011648 FlyBase Gene Snapshot "Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes." FBgn0031505 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; embryonic/larval muscle system; and gut section. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to several human genes including NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2)." FBgn0031467 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in embryonic hypopharynx and embryonic proventriculus. FBgn0031468 Alliance "Enables beta-1,3-galactosyltransferase activity. Involved in protein glycosylation and sexual reproduction. Predicted to be located in membrane. Is expressed in embryonic/larval proventriculus and nurse cell." FBgn0031472 Alliance "Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Is expressed in imaginal disc and male accessory gland. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1)." FBgn0015521 UniProtKB May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva. (UniProtKB:O76927) FBgn0031476 Alliance Is expressed in spermatozoon. FBgn0031478 Alliance Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in retinal dystrophy with leukodystrophy. Orthologous to several human genes including ACBD5 (acyl-CoA binding domain containing 5). FBgn0051950 Alliance "Predicted to enable RNA binding activity. Predicted to be part of NatC complex. Orthologous to human NAA38 (N-alpha-acetyltransferase 38, NatC auxiliary subunit)." FBgn0028970 Alliance "Contributes to Rab geranylgeranyltransferase activity. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and mesoderm. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta)." FBgn0041111 UniProtKB "Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation. (UniProtKB:Q9VQI9)" FBgn0031484 Alliance Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to several human genes including TREX1 (three prime repair exonuclease 1). FBgn0025109 Alliance Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human ABHD13 (abhydrolase domain containing 13). FBgn0025681 Alliance Orthologous to several human genes including FHIP1B (FHF complex subunit HOOK interacting protein 1B). FBgn0031488 Alliance "Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Is expressed in several structures, including dorsal ectoderm; dorsal ectoderm anlage; dorsal epidermis primordium; embryonic epipharynx; and epithelium. Orthologous to several human genes including CCDC85C (coiled-coil domain containing 85C)." FBgn0031492 Interactive Fly "splice factor - regulates histone mRNA expression by modulating transcription - constituent of histone locus body, a chromatin-associated nuclear body that associates with replication-dependent histone gene clusters - regulates alternative splicing of Neurexin IV" FBgn0031494 Alliance "Predicted to enable protein-L-histidine N-tele-methyltransferase activity and protein-lysine N-methyltransferase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)." FBgn0031495 FlyBase Gene Snapshot "beta4GalNAcTB pilot (GABPI) encodes a Golgi multitransmembrane protein of the DHHC family. In contrast to other members of the DHHC family, it lacks palmitoylation activity. It is required for Golgi localization and for the activity of the glycosphingolipid specific glycosyltransferase encoded by beta4GalNAcTB." FBgn0031498 Alliance Predicted to enable zinc ion binding activity. Is expressed in organism. FBgn0031500 Alliance Predicted to enable oxidoreductase activity. Involved in ubiquinone biosynthetic process. Predicted to be active in mitochondrial matrix. Is expressed in adult head; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). FBgn0042627 FlyBase Gene Snapshot Fatty acid synthase 2 (FASN2) encodes an enzyme required for the synthesis of branched/methylated long chain fatty acids that are the precursors of methylated cuticular hydrocarbons. FBgn0003934 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0005779 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in elongation stage spermatid; organism; and testis. FBgn0015600 FlyBase Gene Snapshot "toucan (toc) encodes a protein that associates with spindle microtubules being involved in mitotic spindle organization, mitotic sister chromatid segregation and ovarian follicle cell formation." FBgn0031497 FlyBase Gene Snapshot Seryl-tRNA synthetase (SerRS) encodes a protein that aminoacylates transfer RNAs (tRNA) for their use by the ribosome during protein synthesis. FBgn0031496 Alliance Predicted to enable phosphatase binding activity. Orthologous to human CCDC191 (coiled-coil domain containing 191). FBgn0031493 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in Goldenhar syndrome. Orthologous to human SF3B2 (splicing factor 3b subunit 2)." FBgn0031491 Alliance "Enables alpha-1,4-N-acetylgalactosaminyltransferase activity. Involved in glycosphingolipid biosynthetic process and negative regulation of apoptotic process. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut primordium; eye disc; ganglia; and nurse cell. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)) and A4GNT (alpha-1,4-N-acetylglucosaminyltransferase)." FBgn0031489 Alliance Predicted to enable uridine phosphorylase activity. Predicted to be involved in uridine catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in amnioserosa and amnioserosa anlage. FBgn0002989 FlyBase Gene Snapshot okra (okr) encodes a helicase involved in homologous DNA repair. It functions in meiotic recombination. FBgn0031485 Alliance Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut and organism. Orthologous to human EEF1AKMT2 (EEF1A lysine methyltransferase 2). FBgn0031483 Alliance Is expressed in embryonic/larval muscle system; embryonic/larval visceral muscle cell; organism; somatic muscle primordium; and visceral muscle primordium. FBgn0004584 UniProtKB "Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair (PubMed:16507570, PubMed:1713691). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16507570). Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity). Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:16507570). Has apurinic endonuclease and double-stranded DNA 3'-exonuclease activities and carries out single-stranded DNA renaturation in a Mg(2+)-dependent manner (PubMed:1713691, PubMed:8918793). Activity is more efficient in purine-rich regions of dsDNA than in pyrimidine-rich regions (PubMed:8918793). (UniProtKB:P27864)" FBgn0024920 Alliance "Predicted to enable thymidylate synthase activity. Predicted to be involved in dTMP biosynthetic process. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase)." FBgn0024947 Alliance "Enables GDP phosphatase activity; IDP phosphatase activity; and UDP phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; gland; and salivary gland body primordium. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)) and ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6)." FBgn0031479 Alliance Enables peroxiredoxin activity. Involved in hydrogen peroxide catabolic process. Located in cytosol. Is expressed in adult head and organism. Orthologous to human PRDX6 (peroxiredoxin 6). FBgn0051694 Alliance Located in cytosol. Is expressed in adult brain cell body rind and organism. Orthologous to several human genes including IFRD2 (interferon related developmental regulator 2). FBgn0031473 Alliance Predicted to enable cytoskeletal anchor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in plasma membrane. Is expressed in organism. Orthologous to human ANKRD29 (ankyrin repeat domain 29). FBgn0031471 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0031470 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0031469 Alliance "Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Is expressed in nurse cell and testis. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1)." FBgn0031466 Alliance Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Is expressed in embryonic/larval brain. FBgn0031435 FlyBase Gene Snapshot Early boundary activity 2 (Elba2) encodes a chromatin boundary factor involved in the regulation of chromatin silencing. FBgn0031437 FlyBase Gene Snapshot "Actin-related protein 2/3 complex, subunit 5 (Arpc5) encodes one of seven components of the highly conserved Arp2/3 complex. The Arp2/3 complex is required for many cellular and developmental processes requiring F-actin polymerization, including germline ring canal growth, embryonic cellularization, myoblast fusion, and endocytosis." FBgn0031442 Alliance "Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2)." FBgn0026395 FlyBase Gene Snapshot Odorant receptor 23a (Or23a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0031443 UniProtKB "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (UniProtKB:Q9VQE5)" FBgn0031444 Alliance Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription initiation. Located in cytosol and endoplasmic reticulum. FBgn0041248 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P83292)" FBgn0051690 UniProtKB Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (UniProtKB:Q9VQE9) FBgn0031449 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic small intestine; gut section; and hindgut proper primordium. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4)." FBgn0031452 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2-type spliceosomal complex. Orthologous to human CWC25 (CWC25 spliceosome associated protein homolog)." FBgn0031453 FlyBase Gene Snapshot Bacchus (Bacc) encodes a tyramine-dependent nuclear regulator involved in ethanol sensitivity. FBgn0031456 FlyBase Gene Snapshot "Transportin-Serine/Arginine rich (Tnpo-SR) encodes a importin-beta family protein involved in the regulation of mRNA splicing. It contributes to the import into the nucleus of serine/arginine-rich (SR) proteins, which are involved in mRNA splicing." FBgn0031458 FlyBase Gene Snapshot "anterior pharynx defective 1 (aph-1) encodes a scaffolding subunit of the gamma-secretase complex together with the products of Psn, Nct and pen-2. It is involved in several Notch related processes such as differentiation, cellular organization and developmental patterning via gamma-secretase proteolitic function." FBgn0028398 UniProtKB TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (UniProtKB:Q9U5W9) FBgn0031459 Alliance Predicted to enable adenosine 5'-monophosphoramidase activity. Predicted to be involved in purine ribonucleotide catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). FBgn0031461 FlyBase Gene Snapshot dawdle (daw) encodes an Activin- like ligand of the TGF beta superfamily that is required for proper tricarboxylic acid cycle function in the fat body and also regulates insulin release from IPC neurons. FBgn0031462 Alliance Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Orthologous to human PKM (pyruvate kinase M1/2). FBgn0031463 FlyBase Gene Snapshot Glucose-6-phosphatase (G6P) encodes an enzyme that dephosphorylates glucose-6-phosphate to glucose in the endoplasmic reticulum. It is involved in the last step of gluconeogenesis. FBgn0004242 FlyBase Gene Snapshot Synaptotagmin 1 (Syt1) encodes a synaptic vesicle calcium binding protein that functions as the fast calcium sensor for neurotransmitter release at synapses. FBgn0031460 Alliance Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be active in endomembrane system. FBgn0019830 UniProtKB Putative mitochondrial carrier of unknown solute specificity. Required for gas-filling of the tracheal system at hatching time of the embryo and for normal epithelial morphogenesis of the wings. (UniProtKB:Q9VQG4) FBgn0026324 UniProtKB TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (UniProtKB:Q9XZT7) FBgn0031457 Alliance Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in protein transport. Predicted to be active in early endosome membrane. Is expressed in organism. Orthologous to human SNX20 (sorting nexin 20) and SNX21 (sorting nexin family member 21). FBgn0031451 Alliance Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Predicted to be involved in canonical glycolysis and gluconeogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in spermatozoon. FBgn0031446 Alliance Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription initiation. FBgn0031441 Alliance "Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm." FBgn0026479 FlyBase Gene Snapshot Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability. FBgn0031436 Alliance Predicted to be involved in mitochondrial ATP synthesis coupled electron transport and response to oxidative stress. Part of respiratory chain complex I. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). FBgn0031434 FlyBase Gene Snapshot insensitive (insv) encodes a nuclear factor that functions as a corepressor for the product of Su(H) and negatively regulates Notch signaling. FBgn0026778 FlyBase Gene Snapshot Radiation insensitive 1 (Rad1) encodes a protein that together with proteins encoded by Rad9 and Hus1-like form the 9-1-1 checkpoint protein complex. This complex plays a central role in the DNA damage-induced checkpoint response. FBgn0041337 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:P82713) FBgn0031432 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VQD2) FBgn0031431 Alliance Predicted to enable chromatin binding activity. Predicted to be part of Set1C/COMPASS complex. FBgn0042187 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermatheca. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0031407 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). FBgn0031409 Alliance Predicted to be involved in proteolysis. Orthologous to human PRSS55 (serine protease 55). FBgn0031412 Alliance Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). FBgn0031419 Alliance Predicted to enable double-stranded DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is expressed in organism. Orthologous to human MTERF4 (mitochondrial transcription termination factor 4). FBgn0031420 FlyBase Gene Snapshot "Ataxin 7 (Atxn7) encodes a component of the SAGA chromatin modifying complex, which is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Atxn7 anchors the non-stop containing deubiquitinase module to the remainder of SAGA. Atxn7 is an essential gene for larval survival, neural development, and maintenance of neural tissues." FBgn0031422 Alliance Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). FBgn0031424 FlyBase Gene Snapshot "Vesicular glutamate transporter 1 (VGlut1) encodes a glutamate transporter belonging to SLC family of transporters. It localizes to synaptic vesicles in either glutamatergic or dopaminergic nerve terminals. It has been associated with neurodegenerative processes, regulation of basal and stimulant-induced locomotion, as well as the loading of glutamate and dopamine neurotransmitters into synaptic vesicles and vesicle co-transmission." FBgn0031428 Alliance Predicted to enable glycerate kinase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). FBgn0000490 FlyBase Gene Snapshot "decapentaplegic (dpp) encodes a ligand of the transforming growth factor-beta signaling pathway that signals through Smad transcription factors. It acts as a morphogen that contributes to growth regulation, patterning and stem cell fate." FBgn0011818 UniProtKB Vital for proper neuronal development and hatching. (UniProtKB:Q9NLA6) FBgn0031430 Alliance Orthologous to human CFAP299 (cilia and flagella associated protein 299). FBgn0031426 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0031418 Alliance Predicted to enable D-xylose 1-dehydrogenase (NADP+) activity. Predicted to be involved in D-xylose catabolic process. Is expressed in adult head and adult heart. Orthologous to human DHDH (dihydrodiol dehydrogenase). FBgn0031417 Alliance Predicted to enable D-xylose 1-dehydrogenase (NADP+) activity. Predicted to be involved in D-xylose catabolic process. Is expressed in adult head; head mesoderm; and plasmatocyte primordium. Orthologous to human DHDH (dihydrodiol dehydrogenase). FBgn0014010 FlyBase Gene Snapshot Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. FBgn0031413 Alliance Orthologous to human MKRN2OS (MKRN2 opposite strand). FBgn0028570 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. FBgn0031410 Alliance Predicted to enable myosin heavy chain binding activity. Predicted to be part of myosin II complex. FBgn0051681 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermatheca. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0031406 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in female accessory gland; seminal receptacle; and spermatheca. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0042186 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermatheca. Orthologous to human KLK13 (kallikrein related peptidase 13); PRSS36 (serine protease 36); and PRSS53 (serine protease 53). FBgn0011832 Alliance Predicted to enable serine-type endopeptidase activity. Involved in wound healing. Orthologous to human KLK13 (kallikrein related peptidase 13); PRSS36 (serine protease 36); and PRSS53 (serine protease 53). FBgn0051682 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Is expressed in adult head. FBgn0052463 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human ENDOG (endonuclease G). FBgn0051679 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. FBgn0031374 FlyBase Gene Snapshot WD repeat domain 62 (Wdr62) encodes a protein involved in mitosis regulation. FBgn0051942 Alliance Predicted to enable AGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031378 Alliance Predicted to enable adenosine 5'-monophosphoramidase activity. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3). FBgn0031379 Alliance Is expressed in adult head and organism. Orthologous to human KIAA2013 (KIAA2013). FBgn0031381 FlyBase Gene Snapshot "Niemann-Pick type C-2a (Npc2a) encodes a protein involved in regulating sterol homeostasis and hydroxyecdysone biosynthesis. It also plays a role in the immune signaling via interaction with bacterial lipopolysaccharides, lipid A, peptidoglycan and lipoteichoic acid." FBgn0040717 Alliance Is expressed in embryonic/larval central nervous system. FBgn0051943 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051944 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031384 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). FBgn0011860 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003557 UniProtKB "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation. (UniProtKB:Q9Y0H4)" FBgn0028952 Alliance Enables kinetochore binding activity and microtubule binding activity. Located in kinetochore; perinuclear region of cytoplasm; and spindle microtubule. Is expressed in organism. FBgn0026396 FlyBase Gene Snapshot Odorant receptor 22c (Or22c) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0031388 Alliance Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be part of Cdc73/Paf1 complex. FBgn0027509 FlyBase Gene Snapshot "Tubulin-binding cofactor D (Tbcd) encodes one of the tubulin folding cofactors, which assist in the formation of tubulin heterodimers. It cooperates with the product of Dscam1 to regulate microtubule organization during neural development." FBgn0031392 FlyBase Gene Snapshot Apoptosis inducing factor (AIF) encodes a phylogenetically conserved redox-active flavoprotein that contributes to cell death and oxidative phosphorylation in mitochondria. FBgn0031393 Alliance Is expressed in organism. FBgn0051946 Alliance Predicted to enable AGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031399 FlyBase Gene Snapshot "missing oocyte (mio) encodes a component of the GAP Activity Towards Rags 2 (GATOR2) complex, which promotes the activation of the product of mTor and anabolic metabolism. It localizes to lysosomes and autolysosomes and regulates lysosome function independent of the activity of the product of mTor. It is required for the maintenance of the meiotic cycle." FBgn0031401 UniProtKB "Involved in the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons which is essential for germline integrity (PubMed:21447556, PubMed:29531043). Likely to act by recruiting Piwi proteins such as AGO3 and piwi to the piRNA biogenesis machinery in the nuage (PubMed:21447556, PubMed:29531043). Required for the final steps of primary piRNA biogenesis by participating in the 3' end-trimming of piwi-bound intermediates into mature piRNAs (PubMed:29531043). (UniProtKB:Q9VQ91)" FBgn0040715 Alliance Predicted to be involved in mitochondrial respiratory chain complex III assembly. Is expressed in adult head and adult heart. FBgn0031398 Alliance Involved in primary piRNA processing. Is active in cytoplasmic side of mitochondrial outer membrane. Is expressed in organism. FBgn0010288 UniProtKB Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. (UniProtKB:P35122) FBgn0031397 Alliance Predicted to enable lysophosphatidic acid phosphatase activity. Predicted to be located in cytoplasm. Is expressed in adult head. Orthologous to human PXYLP1 (2-phosphoxylose phosphatase 1). FBgn0053124 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0051668 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0031395 Alliance Predicted to be involved in cilium assembly. Predicted to be located in centrosome. Is expressed in organism. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 1. Orthologous to human CCDC28A (coiled-coil domain containing 28A) and CCDC28B (coiled-coil domain containing 28B). FBgn0000097 FlyBase Gene Snapshot "anterior open (aop) encodes a transcriptional repressor of the ETS family. It acts downstream of receptor tyrosine kinase signaling to regulate cell fate transitions critical to the development of many tissues including the nervous system, heart, trachea and eye." FBgn0031391 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in embryonic/larval corpus allatum and organism. FBgn0031390 FlyBase Gene Snapshot tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs. FBgn0031389 Alliance Predicted to be involved in proteolysis. FBgn0051669 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051940 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051939 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0043539 Alliance Predicted to enable odorant binding activity. Involved in sexual reproduction. Located in extracellular space. FBgn0031377 Alliance "Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Part of Sin3-type complex. Is expressed in spermatozoon. Orthologous to human EMSY (EMSY transcriptional repressor, BRCA2 interacting)." FBgn0031375 FlyBase Gene Snapshot earmuff (erm) encodes a transcriptional repressor that functions as a cell fate regulator by restricting responses to various signaling mechanisms including the Notch pathway during neurogenesis. It contributes to cell fate decisions of the type II neural stem cell in the fly larval brain. FBgn0011859 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0026398 FlyBase Gene Snapshot Odorant receptor 22a (Or22a) encodes a multi-transmembrane chemoreceptor that responds to ethyl butyrate. It localizes to dendritic membranes of neurons in the dorso-medial region of the antenna. FBgn0026397 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses to esters. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. (UniProtKB:P81910)" FBgn0031351 Alliance Is expressed in organism. FBgn0011570 FlyBase Gene Snapshot "capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis." FBgn0031357 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval midgut; embryonic/larval muscle cell; embryonic/larval muscle system; and mesoderm. Orthologous to human MRPL48 (mitochondrial ribosomal protein L48)." FBgn0031360 Alliance "Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human DHRS7 (dehydrogenase/reductase 7)." FBgn0031364 Alliance Is expressed in organism. FBgn0045497 FlyBase Gene Snapshot Gustatory receptor 22e (Gr22e) encodes a member of the gustatory receptor family in taste organs including the labellum and legs. It functions as both a strychnine and chloroquine receptor with other gustatory receptor components. FBgn0031372 Alliance Predicted to be active in endomembrane system and membrane. Is expressed in adult head. FBgn0031373 Alliance Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in 3MC syndrome 3; asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to several human genes including COLEC10 (collectin subfamily member 10); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). FBgn0051663 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic central brain neurons; ganglia; and lateral cord neurons." FBgn0031367 Alliance Predicted to be active in endomembrane system and membrane. Is expressed in adult head; elongation stage spermatid; and primary spermatocyte. FBgn0051933 Alliance Is expressed in adult head. FBgn0045501 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58951)" FBgn0045498 FlyBase Gene Snapshot Gustatory receptor 22d (Gr22d) encodes a transmembrane domain protein unrelated to GPCRs that is predicted to mediate response to non-volatile compounds. FBgn0041249 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58954)" FBgn0027597 Alliance Predicted to enable nucleotide binding activity. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human GFOD1 (Gfo/Idh/MocA-like oxidoreductase domain containing 1) and GFOD2 (Gfo/Idh/MocA-like oxidoreductase domain containing 2). FBgn0031361 Alliance Predicted to enable small ribosomal subunit rRNA binding activity. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human UTP23 (UTP23 small subunit processome component). FBgn0000579 FlyBase Gene Snapshot Enolase (Eno) encodes a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate and is involved in glycolysis. The reverse reaction is involved in gluconeogenesis. FBgn0031359 FlyBase Gene Snapshot Replication in mitochondria 2 (Rim2) encodes a mitochondrial carrier involved in the transport of deoxynucleotides and is essential to maintain mtDNA maintenance and replication. FBgn0031356 Alliance "Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be active in Golgi apparatus and membrane. Is expressed in adult head. Orthologous to several human genes including TMEM87A (transmembrane protein 87A)." FBgn0021906 Alliance "Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1)." FBgn0051935 UniProtKB "Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (Probable). As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (Probable). Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (Probable). The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (By similarity). At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (Probable). Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (Probable). The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity). Regulates autophagy as part of a Rab3GAP-Rab18 module (PubMed:32248620). Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I (PubMed:32248620). (UniProtKB:Q9VQ26)" FBgn0031347 Alliance Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 35. Orthologous to human QRICH2 (glutamine rich 2). FBgn0001174 FlyBase Gene Snapshot halo (halo) encodes a protein that acts as cofactor of the molecular motor kinesin-1 and controls travel distances of moving lipid droplets. It determines the intracellular distribution of lipid droplets. FBgn0031345 Alliance Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. FBgn0031327 Alliance Is expressed in adult head; embryonic/larval plasmatocyte; and embryonic/larval tracheal dorsal trunk. FBgn0041097 FlyBase Gene Snapshot roundabout 3 (robo3) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand. It is involved in the development of the nervous system and gonad. FBgn0011294 Alliance Is expressed in coeloconic sensillum of antennal segment 3; spermatozoon; and third segment of antenna. FBgn0031331 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human UBE2E1 (ubiquitin conjugating enzyme E2 E1); UBE2E2 (ubiquitin conjugating enzyme E2 E2); and UBE2E3 (ubiquitin conjugating enzyme E2 E3). FBgn0026141 UniProtKB Acts as a non-catalytic accessory component of a dynein complex. (UniProtKB:O96860) FBgn0051928 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Located in egg chorion. Orthologous to human PGA3 (pepsinogen A3); PGA4 (pepsinogen A4); and PGA5 (pepsinogen A5). FBgn0053128 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Orthologous to several human genes including CTSE (cathepsin E); PGA3 (pepsinogen A3); and PGA4 (pepsinogen A4). FBgn0051926 Alliance Predicted to enable aspartic-type endopeptidase activity. Involved in egg chorion assembly. Predicted to be active in lysosome. Orthologous to human PGA3 (pepsinogen A3); PGA4 (pepsinogen A4); and PGA5 (pepsinogen A5). FBgn0051661 Alliance Predicted to enable aspartic-type endopeptidase activity. Involved in egg chorion assembly. Predicted to be active in lysosome. Orthologous to human PGA3 (pepsinogen A3); PGA4 (pepsinogen A4); and PGA5 (pepsinogen A5). FBgn0031344 Alliance Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). FBgn0002543 FlyBase Gene Snapshot "roundabout 2 (robo2) encodes a member of the Robo receptor family that responds to the ligand encoded by sli as a repulsive cue in axons, dendrites, muscles, trachea and heart development. It can also inhibit robo1 signaling, likely explaining why the product of robo2 can appear to be an attractive receptor in certain contexts." FBgn0053126 FlyBase Gene Snapshot "Neural Lazarillo (NLaz) encodes an extracellular lipid binding protein of the Lipocalin family. It is regulated by JNK signaling and negatively regulates the IIS pathway. It contributes to longevity, stress resistance, and behavior." FBgn0051659 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0031335 Alliance Predicted to enable pseudouridine 5'-phosphatase activity. Is expressed in spermatozoon. Orthologous to human PUDP (pseudouridine 5'-phosphatase). FBgn0051924 Alliance Predicted to enable pseudouridine 5'-phosphatase activity. Orthologous to human PUDP (pseudouridine 5'-phosphatase). FBgn0031333 Alliance Predicted to enable phosphatase activity. Is expressed in organism. FBgn0031332 Alliance Predicted to enable phosphatase activity. Is expressed in spermatozoon. FBgn0028481 UniProtKB Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (UniProtKB:Q9V3X5) FBgn0031296 Alliance Enables ribosome binding activity. Predicted to be involved in protein targeting to membrane. Part of nascent polypeptide-associated complex. Is expressed in adult head; fat body/gonad primordium; germline cell; and gonad. FBgn0015905 FlyBase Gene Snapshot asteroid (ast) encodes an interactor protein of the product of Egfr that is involved in photoreceptor and wing development. FBgn0031298 FlyBase Gene Snapshot Autophagy-related 4a (Atg4a) encodes a protein involved in autophagy. FBgn0031301 Alliance Predicted to be involved in cilium assembly and cilium movement. Predicted to be active in motile cilium. FBgn0031302 Alliance Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection. Orthologous to human RGS7BP (regulator of G protein signaling 7 binding protein). FBgn0031304 Alliance "Predicted to enable GTPase activator activity. Involved in positive regulation of intracellular transport. Located in recycling endosome and trans-Golgi network. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle system; foregut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 11. Orthologous to human TBC1D23 (TBC1 domain family member 23)." FBgn0031306 Alliance Is expressed in adult head. FBgn0031307 Alliance "Enables glucose transmembrane transporter activity and trehalose transmembrane transporter activity. Involved in glucose transmembrane transport. Located in plasma membrane. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; gut section; and tracheal primordium." FBgn0031310 FlyBase Gene Snapshot Vacuolar protein sorting 29 (Vps29) encodes a subunit of the retromer complex involved in cargo recognition and recycling from endosomes to the trans-Golgi network or plasma membrane. FBgn0031312 Alliance "Predicted to enable transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Involved in protein secretion. Located in endoplasmic reticulum. Is expressed in adult head. Used to study Parkinson's disease and epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit)." FBgn0031314 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. (UniProtKB:Q9VPY0)" FBgn0031315 Alliance Predicted to be involved in spermatogenesis. Is expressed in organism. Orthologous to human MEA1 (male-enhanced antigen 1). FBgn0051922 Alliance "Predicted to enable zinc ion binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex and small nuclear ribonucleoprotein complex. Orthologous to human ZMAT5 (zinc finger matrin-type 5)." FBgn0031318 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in adult brain; adult pars intercerebralis; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to several human genes including RBM10 (RNA binding motif protein 10) and RBM5 (RNA binding motif protein 5)." FBgn0031319 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to human RBM10 (RNA binding motif protein 10) and RBM5 (RNA binding motif protein 5)." FBgn0031321 UniProtKB "Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4, 5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product. (UniProtKB:Q9VPY8)" FBgn0031320 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in organism. FBgn0031317 FlyBase Gene Snapshot Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp1-dependent transcriptional responses downstream of the innate immune pathway. FBgn0024314 Alliance "Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; embryonic/larval nervous system; and ganglia. Orthologous to human PLAA (phospholipase A2 activating protein)." FBgn0031313 Alliance "Located in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval lateral glial cell; embryonic/larval muscle cell; ganglia; and visceral mesoderm derivative." FBgn0031309 Alliance Predicted to be involved in nucleotide-excision repair; response to UV; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). FBgn0031305 Alliance Is expressed in adult head and organism. FBgn0016926 UniProtKB Plays a role in olfaction. (UniProtKB:Q9VPW8) FBgn0031299 Alliance Predicted to enable protein serine/threonine kinase activity. Is expressed in adult head; embryonic proventriculus; embryonic proventriculus intermediate layer; embryonic/larval oenocyte; and larval foregut atrium. Orthologous to human NIM1K (NIM1 serine/threonine protein kinase). FBgn0003310 FlyBase Gene Snapshot "Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning." FBgn0031273 Alliance Predicted to enable signaling receptor activity. Predicted to be located in extracellular region. FBgn0011244 UniProtKB Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (UniProtKB:Q9VPS5) FBgn0031275 FlyBase Gene Snapshot metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. FBgn0040725 Alliance Is expressed in testis. FBgn0041250 FlyBase Gene Snapshot "Gustatory receptor 21a (Gr21a) encodes a transmembrane domain protein unrelated to GPCRs. Together with the product Gr63a, it forms a heteromultimeric receptor for carbon dioxide, an important chemosensory cue for insects." FBgn0031279 Alliance Predicted to enable D-xylulokinase activity. Predicted to be involved in carbohydrate phosphorylation and xylulose metabolic process. Predicted to be located in extracellular exosome. Predicted to be active in cytosol. Is expressed in embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. Orthologous to human XYLB (xylulokinase). FBgn0051658 FlyBase Gene Snapshot "Nnf1b (Nnf1b) encodes a component of the Mis12 complex, which is an essential constituent of the kinetochore." FBgn0031282 FlyBase Gene Snapshot Peroxin 12 (Pex12) encodes a peroxisome protein important for sperm development. FBgn0015621 UniProtKB "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (UniProtKB:Q9VPT8)" FBgn0010583 UniProtKB "Adapter protein that links cell surface receptor tyrosine phosphorylation to downstream signaling pathways and effectors, many of which are involved in regulation of the actin cytoskeleton (PubMed:8646773). Recruited by Dscam1/Down syndrome cell adhesion molecule homolog and InR/insulin-like receptor (PubMed:10892653, PubMed:12702880). Recruits Pak to membranes, probably when dock/dreadlocks is associated with activated receptors (PubMed:10399914). Required for guidance and targeting of photoreceptor (R cell) axon projections but not for axon outgrowth, differentiation or target induction in the developing eye (PubMed:10399914, PubMed:12702880, PubMed:8646773, PubMed:9482841). As part of a signaling pathway that involves the lbm/late bloomer protein, involved in synapse formation of the RP3 motorneuron at the muscle 7/6 cleft, probably by stimulating axon defasciculation from other SNb neurons (PubMed:10068645). (UniProtKB:Q8IPW2)" FBgn0020545 UniProtKB May have a role in detoxification and digestion during embryogenesis and larval development. (UniProtKB:O18391) FBgn0031288 Alliance Is expressed in embryonic/larval muscle system and embryonic/larval somatic muscle cell. FBgn0031289 Alliance Predicted to enable carbohydrate binding activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in asthma. Orthologous to several human genes including CLC (Charcot-Leyden crystal galectin); LGALS1 (galectin 1); and LGALS12 (galectin 12). FBgn0002936 UniProtKB PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. (UniProtKB:P15425) FBgn0002563 UniProtKB Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (UniProtKB:P11996) FBgn0046113 FlyBase Gene Snapshot Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. FBgn0003916 Alliance "Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP." FBgn0020305 UniProtKB "Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development. (UniProtKB:Q9VPU8)" FBgn0029095 FlyBase Gene Snapshot "arouser (aru) encodes an SH3 adaptor protein that interacts with Egfr and PI3K pathways. Its roles include regulation of synapse number, memory formation and ethanol sedation sensitivity." FBgn0031287 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Orthologous to human WBP4 (WW domain binding protein 4)." FBgn0020304 Interactive Fly ArfGAP - induces the hydrolysis of GTP that is bound to Arf proteins - during oogenesis essential for the initial detachment of the border cell cluster from the basal lamina - acts antagonistically to the guanine exchange factor Steppke - temporally controlled expression is achieved by translational repression of drongo mRNA within P-bodies - requires Rab11 for proper localization at the oocyte's cortex during mid-oogenesis FBgn0031286 Alliance Predicted to enable guanyl-nucleotide exchange factor activity and rRNA binding activity. Predicted to be involved in mitochondrial fusion and positive regulation of mitochondrial translation. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human RCC1L (RCC1 like). FBgn0031284 UniProtKB Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). (UniProtKB:Q9VPT7) FBgn0031283 Alliance Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. FBgn0031281 FlyBase Gene Snapshot "SAGA factor-like TAF6 (Saf6) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Saf6 replaces the product of mia within SAGA when the product of mia is restricted to the TFIID transcription complex. Notably, the product of Saf6 is essential for SAGA's co-activator function but does not impact either of its enzymatic activities." FBgn0000442 FlyBase Gene Snapshot "Protein kinase, cGMP-dependent at 21D (Pkg21D) encodes a Mg[+] dependent-kinase that is activated by cGMP. It contributes to somatic muscle development, salivary gland morphogenesis and epithelial fluid transport." FBgn0026438 FlyBase Gene Snapshot Excitatory amino acid transporter 2 (Eaat2) encodes a transmembrane protein involved in aspartate and taurine transport. FBgn0040106 Alliance Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteoarthritis and retinal macular dystrophy 4. Orthologous to human CLEC3B (C-type lectin domain family 3 member B). FBgn0004611 FlyBase Gene Snapshot Phospholipase C at 21C (Plc21C) encodes a phospholipase C beta involved in olfaction and flight. It functions downstream of G-protein-coupled receptors coupled to Gq. FBgn0053127 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head. FBgn0000061 UniProtKB Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development. (UniProtKB:Q06453) FBgn0003278 UniProtKB DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). (UniProtKB:P20028) FBgn0002593 FlyBase Gene Snapshot Ribosomal protein LP1 (RpLP1) encodes a member of the cytoplasmic large ribosomal protein family. FBgn0031254 Alliance Predicted to enable GTP binding activity and GTPase activity. Orthologous to human ARL16 (ADP ribosylation factor like GTPase 16). FBgn0031255 Alliance Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). FBgn0004583 FlyBase Gene Snapshot "expanded (ex) encodes a FERM-domain containing protein that localizes to apical cell-cell junctions, where it promotes Hippo signaling by physically interacting with multiple Hippo pathway components. Through its regulation of Hippo signaling, the product of ex functions as an inhibitor of growth." FBgn0031256 FlyBase Gene Snapshot shriveled (shv) encodes a secreted protein that activates integrin signaling. It is involved in synapse maturation regulation and stem cell maintenance. FBgn0031257 Alliance "Is expressed in several structures, including adult head; anterior endoderm; ganglia; sense organ; and sensory nervous system primordium." FBgn0027592 FlyBase Gene Snapshot Mediator complex subunit 15 (MED15) encodes a subunit of the mediator complex required for regulating RNA polymerase II transcripts. Mediator complex subunits function as Notch signaling modulators. FBgn0003963 FlyBase Gene Snapshot "u-shaped (ush) encodes a member of the Friend of GATA (FOG) multi-type zinc finger protein family, which bind GATA factors (like those encoded by srp or pnr). These complexes can interface with major signal transduction pathways such as TGFbeta, Hedgehog, JAK/STAT and Insulin/PI3K to regulate diverse biological processes such as embryonic development, heart, blood and neural development and body size." FBgn0031263 FlyBase Gene Snapshot "Translocator protein (Tspo) encodes a protein localized in the outer mitochondrial membrane that is thought to be involved in various pathways, including steroid and heme biosynthesis, apoptosis, protein import, cell proliferation and differentiation and also has been proposed to participate in the formation of the mitochondrial permeability transition pore." FBgn0031265 Alliance "Predicted to enable hydrolase activity, acting on glycosyl bonds and pseudouridylate synthase activity. Predicted to be active in cytoplasm." FBgn0031266 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in spliceosomal complex assembly. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult heart. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1). FBgn0031268 FlyBase Gene Snapshot coiled (cold) encodes a membrane glycoprotein of the Ly6 family that is required for the formation of septate junctions in both epithelial tissues and in sub-perineural glial cells. FBgn0023489 FlyBase Gene Snapshot "PvuII-PstI homology 13 (Pph13) encodes a paired-class homeodomain protein. It is critical for rhabdomeric photoreceptor differentiation, phototransduction and rhabdomere morphogenesis." FBgn0010323 FlyBase Gene Snapshot Goosecoid (Gsc) encodes a homeoprotein that shares DNA binding sequence specificity with the products of bcd and oc. It regulates cell fate in the brain and stomatogastric nervous system. FBgn0013323 FlyBase Gene Snapshot Prothoracicotropic hormone (Ptth) encodes a secreted neuropeptide that regulates ecdysone production contributing to larval to pupal transition. It signals through Torso/RAS/Erk pathway. It also modulates larval light avoidance independently of ecdysone. FBgn0031267 FlyBase Gene Snapshot Ipk2 (Ipk2) encodes a kinase involved in imaginal disc development and biosynthesis of inositol phosphate. FBgn0021874 UniProtKB Plays a role in regulating Notch activity. (UniProtKB:Q9VPR4) FBgn0031264 Alliance Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human BTF3L4 (basic transcription factor 3 like 4). FBgn0005660 FlyBase Gene Snapshot "Ets at 21C (Ets21C) encodes a stress-inducible transcription factor that binds specifically to purine-rich DNA motifs. It cooperates with transcription factors acting downstream of the MAP kinase pathways to fine tune gene expression in response to stress, such as infection or oncogene activation." FBgn0031260 Alliance "Enables aspartic endopeptidase activity, intramembrane cleaving. Involved in cellular response to unfolded protein and signal peptide processing. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including adult head; embryonic proventriculus; epithelium; imaginal disc; and presumptive embryonic salivary gland. Orthologous to human HM13 (histocompatibility minor 13)." FBgn0010602 FlyBase Gene Snapshot "lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo." FBgn0043364 FlyBase Gene Snapshot cabut (cbt) encodes a transcription factor that controls Dpp signaling and is involved in dorsal closure and wing disc morphogenesis. FBgn0015924 FlyBase Gene Snapshot croquemort (crq) encodes a member of the scavenger receptor class B sub-family. It is expressed in plasmatocyte/macrophages and promotes apoptotic cell clearance. In epidermal cells it plays a role in phagosome maturation in both dendrite pruning and injury. FBgn0031253 Alliance Predicted to be involved in proteasome assembly. FBgn0031252 UniProtKB "Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (UniProtKB:Q9VPP5)" FBgn0031251 Alliance "Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic pars intercerebralis; embryonic/larval nervous system; and ganglia." FBgn0031250 Alliance Predicted to enable nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)); SLC29A2 (solute carrier family 29 member 2); and SLC29A3 (solute carrier family 29 member 3). FBgn0031249 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0031248 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human CTRC (chymotrypsin C). FBgn0067779 FlyBase Gene Snapshot "debra (dbr) encodes a transcriptional coactivator of various transcription factors, including the products of ci and dl. It contributes to developmental patterning, long-term memory, and cellular proliferation." FBgn0031213 FlyBase Gene Snapshot galectin (galectin) encodes a galactoside binding protein involved in synaptic target recognition. FBgn0031214 Alliance Predicted to enable carbohydrate binding activity and galactoside binding activity. Orthologous to several human genes including LGALS4 (galectin 4); LGALS9 (galectin 9); and LGALS9B (galectin 9B). FBgn0031216 FlyBase Gene Snapshot Zizimin-related (Zir) encodes a Rho guanine nucleotide exchange factor involved in the cellular immune response. FBgn0031217 Alliance Predicted to enable calcium ion binding activity. Involved in mitochondrion organization. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in adult head. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1) and CRELD2 (cysteine rich with EGF like domains 2). FBgn0001142 FlyBase Gene Snapshot "Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells." FBgn0031224 Alliance "Predicted to enable mRNA binding activity and single-stranded RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to several human genes including RBM7 (RNA binding motif protein 7)." FBgn0031228 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; embryonic/larval muscle cell; endoderm anlage; and mesoderm. Orthologous to human NDUFS5 (NADH:ubiquinone oxidoreductase subunit S5)." FBgn0031229 Alliance "Predicted to enable RNA binding activity. Involved in mitotic cell cycle. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Orthologous to human SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)." FBgn0031231 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human MRPL10 (mitochondrial ribosomal protein L10). FBgn0031233 Alliance Enables small GTPase binding activity. Is expressed in embryonic/larval midgut and organism. Orthologous to human TBC1D15 (TBC1 domain family member 15) and TBC1D17 (TBC1 domain family member 17). FBgn0031235 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme and ciliary basal body. Orthologous to human CFAP263 (cilia and flagella associated protein 263). FBgn0031240 Alliance Is expressed in spermatozoon. FBgn0003444 FlyBase Gene Snapshot "smoothened (smo) encodes a critical component of the Hedgehog signaling pathway. It is regulated by phosphorylation, dimerization, and cell-surface accumulation upon Hedgehog stimulation. The product of smo is also regulated by ubiquitin and other small molecules such as phospholipids." FBgn0031247 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be active in mitochondrion. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 19. Orthologous to human PET117 (PET117 cytochrome c oxidase chaperone). FBgn0024352 Alliance Predicted to enable Hsp90 protein binding activity. Involved in multivesicular body fusion to apical plasma membrane. Is expressed in adult head. Orthologous to human STIP1 (stress induced phosphoprotein 1). FBgn0020622 FlyBase Gene Snapshot Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional class IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation. FBgn0017457 FlyBase Gene Snapshot U2 small nuclear riboprotein auxiliary factor 38 (U2af38) encodes the small subunit of the pre-mRNA splicing factor complex U2AF. This heterodimeric complex binds to the intron pyrimidine tract and targets the product of snf to the branch site early in spliceosome assembly. The U2af38 product binds to the AG dinucleotide at the 3' splice site. FBgn0025686 FlyBase Gene Snapshot "Amnionless (Amnionless) is an evolutionarily conserved gene that encodes a type I transmembrane coreceptor which forms part of the 'Cubam' receptor complex with Cubn. This complex is required for vitamin B12 transport in the gut and protein uptake by insect nephrocytes, as well as protein reabsorption by mammalian renal epithelial cells. Mutations in the human gene are associated with the rare autosomal recessive condition Imerslund-Grasbeck syndrome, a form of vitamin B12 deficiency." FBgn0031245 Alliance "Predicted to be located in membrane. Predicted to be active in endomembrane system. Is expressed in several structures, including Bolwig organ; adult head; central brain primordium; dorsal epidermis primordium; and ganglia. Orthologous to several human genes including AIG1 (androgen induced 1)." FBgn0031244 Alliance Predicted to be located in membrane. Predicted to be active in endomembrane system. Is expressed in adult head and organism. Orthologous to several human genes including AIG1 (androgen induced 1). FBgn0031238 Alliance Predicted to enable tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS1L (dihydrouridine synthase 1 like). FBgn0031239 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in embryonic/larval central nervous system. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1); ZDHHC11 (zinc finger DHHC-type containing 11); and ZDHHC11B (zinc finger DHHC-type containing 11B). FBgn0031232 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; muscle organ development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in embryonic/larval muscle system; embryonic/larval somatic muscle cell; wing hinge primordium; and wing pouch. Orthologous to human MKX (mohawk homeobox)." FBgn0031227 UniProtKB Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. (UniProtKB:Q9VPK7) FBgn0051974 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult fat body; adult head; and spermatozoon. FBgn0051975 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0031219 Alliance Is expressed in adult fat body. FBgn0026787 Alliance "Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport and regulation of intracellular pH. Predicted to be located in membrane. Is expressed in several structures, including adult Malpighian tubule; adult head; adult hindgut; male accessory gland; and testis. Orthologous to human SLC9A8 (solute carrier family 9 member A8)." FBgn0002931 FlyBase Gene Snapshot net (net) encodes a basic helix-loop-helix protein that probably acts as a transcriptional repressor. During wing vein formation it is expressed in all interveins territories and antagonises the activity of the product of Egfr. FBgn0051973 Alliance "Predicted to enable chitin deacetylase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in extracellular region. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; epidermis; and gut section." FBgn0031209 UniProtKB "Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation) (PubMed:27126188, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27656904). (UniProtKB:Q9VPI2)" FBgn0002121 FlyBase Gene Snapshot "lethal (2) giant larvae (l(2)gl) encodes a tumor suppressor protein that regulates cell polarity and asymmetric cell division. It acts on the basolateral side of epithelial cells, antagonizing the activity of apical complex proteins encoded by baz, par-6 and aPKC." FBgn0036970 FlyBase Gene Snapshot Serpin 77Bc (Spn77Bc) encodes a protein produced by the male accessory glands and transferred to females during mating. FBgn0036974 UniProtKB "Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (UniProtKB:Q9VPH7)" FBgn0036975 Alliance Predicted to enable glutamate decarboxylase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in cytoplasm. Is expressed in embryonic small intestine; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval posterior spiracle; and embryonic/larval tracheal dorsal trunk. Orthologous to human GADL1 (glutamate decarboxylase like 1). FBgn0024887 Alliance Predicted to enable double-stranded DNA binding activity. Predicted to be involved in DNA damage response and DNA replication. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human KIN (Kin17 DNA and RNA binding protein). FBgn0036977 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0001259 FlyBase Gene Snapshot "inturned (in) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway, which controls hair and bristle polarity in the adult. In directly binds with the products of fy, frtz and mwh and accumulates on the proximal side of wing cells." FBgn0036980 FlyBase Gene Snapshot Rho-related BTB domain containing (RhoBTB) encodes a protein involved in anti-parasitoid immune response. FBgn0036985 Alliance "Predicted to be a structural constituent of chitin-based cuticle. Involved in several processes, including apical constriction; cell-matrix adhesion; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in trichome." FBgn0036991 Alliance "Involved in DNA double-strand break processing involved in repair via single-strand annealing and double-strand break repair via homologous recombination. Is expressed in several structures, including Malpighian tubule primordium; central brain primordium; embryonic hindgut; embryonic/larval nervous system; and ganglia." FBgn0036996 FlyBase Gene Snapshot "magro (mag) encodes a lipase induced by the product of Hr96 in the intestine, where it acts in the lumen to degrade dietary triglycerides for fatty acid absorption." FBgn0036997 Alliance Predicted to enable L-threonine 3-dehydrogenase activity. Predicted to be involved in threonine catabolic process. Is expressed in adult head. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)). FBgn0036998 UniProtKB Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. (UniProtKB:Q9VPE4) FBgn0036999 FlyBase Gene Snapshot iso Glutaminyl cyclase (isoQC) encodes a glutaminyl-peptide cyclotransferase involved in peptidyl-pyroglutamic acid biosynthesis. FBgn0037001 FlyBase Gene Snapshot "NADH dehydrogenase (ubiquinone) 39 kDa subunit (ND-39) encodes a subunit of mitochondrial respiratory complex I (cI, NADH:ubiquinone oxidoreductase)." FBgn0052425 Alliance Predicted to be involved in centriole elongation and cilium assembly. Predicted to be active in centriolar satellite and centriole. Is expressed in organism. Human ortholog(s) of this gene implicated in orofaciodigital syndrome. Orthologous to human C2CD3 (C2 domain containing 3 centriole elongation regulator). FBgn0037003 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A) and MFSD14B (major facilitator superfamily domain containing 14B). FBgn0037004 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A) and MFSD14B (major facilitator superfamily domain containing 14B). FBgn0037005 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A) and MFSD14B (major facilitator superfamily domain containing 14B). FBgn0037009 Alliance Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. Orthologous to human SFT2D1 (SFT2 domain containing 1) and SFT2D2 (SFT2 domain containing 2). FBgn0037011 UniProtKB "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The Nubp1-Nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. (UniProtKB:Q9VPD2)" FBgn0001323 FlyBase Gene Snapshot "knirps-like (knrl) encodes an orphan nuclear hormone receptor with a C4 zinc finger motif, without ligand-binding domain. It is a target gene of the Hedgehog, Wingless and Notch signaling pathways. It controls endoreduplication domains and epithelial morphogenesis in the fore- and hindgut." FBgn0037012 Alliance Involved in centriole replication. Located in plasma membrane. FBgn0037008 UniProtKB "Binds promoter DNA and regulates initiation of transcription (By similarity). Regulator of mitochondrial ribosome biogenesis and translation that is essential for development (PubMed:16787637, PubMed:23300484). Required for normal mitochondrial transcription and translation (PubMed:16787637, PubMed:23300484). Required for assembly of mitochondrial respiratory complexes and normal mitochondrial function (PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:23300484). (UniProtKB:Q9VPD5)" FBgn0037007 Alliance "Predicted to be involved in mitochondrial outer membrane permeabilization and regulation of programmed cell death. Located in nucleus. Is expressed in several structures, including adult brain cell body rind; anlage in statu nascendi; extraembryonic structure; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including BNIP3 (BCL2 interacting protein 3)." FBgn0037000 FlyBase Gene Snapshot Zinc transporter 77C (ZnT77C) encodes a protein involved in zinc detoxification and zinc transmembrane import. FBgn0052428 Alliance "Is expressed in several structures, including embryonic/larval midgut primordium; hindgut proper primordium; mesoderm; and somatic muscle primordium." FBgn0036995 FlyBase Gene Snapshot "artichoke (atk) encodes a leucine-rich-repeat extracellular matrix protein secreted by accessory cells in ciliated sensory organs. It surrounds the tip of the cilium, and contributes to its assembly. Its roles include cilium integrity, chemosensation and proprioception." FBgn0036994 Alliance Predicted to enable proteasome binding activity. Involved in proteasome localization. Colocalizes with nuclear membrane. Is expressed in organism. FBgn0036992 Alliance Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in adult head; embryonic dorsal epidermis; and embryonic ventral epidermis. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). FBgn0036990 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Used to study DiGeorge syndrome. Orthologous to human MRPL15 (mitochondrial ribosomal protein L15). FBgn0029158 UniProtKB "Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (UniProtKB:Q7JQW6)" FBgn0036988 Alliance Is expressed in organism. Orthologous to human TMEM104 (transmembrane protein 104). FBgn0036987 Alliance Orthologous to human INTS15 (integrator complex subunit 15). FBgn0036986 Alliance Predicted to be involved in proteolysis. Is expressed in adult head; central brain primordium; ganglia; gut section; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to human DPEP1 (dipeptidase 1); DPEP2 (dipeptidase 2); and DPEP3 (dipeptidase 3). FBgn0036984 Alliance "Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; brain; embryonic central brain neurons; embryonic/larval central nervous system; and embryonic/larval nervous system. Orthologous to human SLC7A4 (solute carrier family 7 member 4)." FBgn0028978 FlyBase Gene Snapshot "tribbles (trbl) encodes the founding member of the Trib family of kinase-like proteins. It contributes to cell growth, cell migration and metabolism." FBgn0027565 Alliance "Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human CHMP7 (charged multivesicular body protein 7)." FBgn0001247 FlyBase Gene Snapshot Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. FBgn0036978 FlyBase Gene Snapshot Toll-9 (Toll-9) encodes a transmembrane signalling receptor belonging to the Toll family of protein. FBgn0036973 UniProtKB Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. (UniProtKB:Q9VPH8) FBgn0037014 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in cilium assembly. Predicted to be active in cilium and microtubule. Is expressed in spermatozoon. Orthologous to human CCDC66 (coiled-coil domain containing 66). FBgn0037016 Alliance Is expressed in Malpighian tubule primordium; adult head; embryonic Malpighian tubule; embryonic epipharynx; and gut section. FBgn0040634 Alliance Predicted to be involved in mitochondrial respiratory chain complex assembly. Predicted to be active in mitochondrion. Orthologous to human CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7). FBgn0016696 UniProtKB Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity). (UniProtKB:Q9VPC0) FBgn0037020 Alliance Predicted to enable protein transmembrane transporter activity and signaling receptor binding activity. Involved in protein import into peroxisome matrix. Located in peroxisome. Is expressed in adult head; embryonic cortex; mesoderm; organism; and yolk. Used to study peroxisome biogenesis disorder 13A. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 13A. Orthologous to human PEX14 (peroxisomal biogenesis factor 14). FBgn0037024 Alliance Predicted to enable hydroxyacylglutathione hydrolase activity. Involved in response to hypoxia. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). FBgn0037025 FlyBase Gene Snapshot "Spc105-related (Spc105R) encodes an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. The products of Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore." FBgn0037027 FlyBase Gene Snapshot "HP1 and insulator partner protein 1 (HIPP1) encodes a chromatin-associated protein, displaying strong protein-protein interaction with the product of Su(var)205. It is localized to pericentric heterochromatin, and potentially has a separate role bound to insulators along with the products of su(Hw), mod(mdg4) and Cp190." FBgn0040636 Alliance Is expressed in adult head and adult heart. FBgn0037031 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ganglia; germline cell; gonad; and ventral nerve cord primordium." FBgn0040637 Alliance Predicted to be located in extracellular space. FBgn0037035 Alliance Is expressed in spermatozoon. FBgn0011591 FlyBase Gene Snapshot "fringe (fng) encodes a glycosyltransferase that modifies EGF domains of the product of N. This glycosylation enhances the interactions the product of N with its ligand encoded by Delta, and inhibits those with its ligand encoded by Ser. In this way the product of fng modulates Notch signaling." FBgn0052432 Alliance Predicted to be active in plasma membrane. Is expressed in adult head and embryonic central brain. FBgn0027055 FlyBase Gene Snapshot COP9 signalosome subunit 3 (CSN3) encodes the subunit 3 of the COP9 signalosome (CSN) and is essential for the stability of the complex. The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. FBgn0037026 Alliance Is expressed in adult head. Orthologous to several human genes including ST7 (suppression of tumorigenicity 7). FBgn0027364 FlyBase Gene Snapshot Six4 (Six4) encodes a homeodomain-containing transcription factor required for mesodermal patterning to form the embryonic gonad. FBgn0037022 Alliance Predicted to be involved in Golgi vesicle transport. Located in Golgi apparatus. Part of TRAPPIII protein complex. Is expressed in adult head and organism. Orthologous to human TRAPPC12 (trafficking protein particle complex subunit 12). FBgn0037021 Alliance Enables RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in wing disc dorsal/ventral pattern formation. Located in nucleus. Orthologous to human PCIF1 (phosphorylated CTD interacting factor 1). FBgn0037019 FlyBase Gene Snapshot "Peroxin 16 (Pex16) encodes a protein involved in peroxisome organization, spermatocyte division, and fatty acid catabolism." FBgn0037018 Alliance "Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle cell. Orthologous to human DMAC2 (distal membrane arm assembly component 2)." FBgn0037017 Alliance "Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to be part of retromer, cargo-selective complex. Predicted to be active in endosome. Orthologous to human VPS26C (VPS26 endosomal protein sorting factor C)." FBgn0045474 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IPU5)" FBgn0037015 Interactive Fly cysteine-rich transmembrane BMP regulator - physically interacts with and inhibits BMP ligand glass bottom boat in motoneurons thus permitting the muscle-derived Gbb pool to predominate at the NMJ and establishing the retrograde directionality of the pro-growth BMP pathway FBgn0001320 UniProtKB Transcriptional repressor. Binds to multiple sites in the eve stripe 3 enhancer element. Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression. (UniProtKB:P10734) FBgn0037037 Alliance Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in spermatozoon. Orthologous to human NRDC (nardilysin convertase). FBgn0037044 Alliance "Predicted to enable prenyltransferase activity. Predicted to contribute to all-trans-decaprenyl-diphosphate synthase activity. Predicted to be involved in isoprenoid biosynthetic process and ubiquinone biosynthetic process. Predicted to be part of heterotetrameric polyprenyl diphosphate synthase complex. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; gut section; and visceral muscle primordium. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 3. Orthologous to human PDSS2 (decaprenyl diphosphate synthase subunit 2)." FBgn0028402 Alliance Predicted to be involved in tRNA transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in organism. Orthologous to human POLR3E (RNA polymerase III subunit E). FBgn0026179 FlyBase Gene Snapshot IQ motif and Sec7 domain ArfGEF (Iqsec) encodes an Arf1 guanine nucleotide exchange factor involved in commissural axon guidance and myoblast fusion. FBgn0037050 FlyBase Gene Snapshot Islet cell autoantigen 69 kDa (ICA69) encodes a protein that belongs to the BAR (Bin-Amphiphysin-Rvs) family of proteins. It regulates ionotropic glutamate receptor clustering at the neuromuscular junctions and controls synapse morphogenesis through a pathway that involves Spectrin and the product of Rab2. FBgn0037057 Alliance Predicted to enable oxidoreductase activity. Is expressed in adult brain; adult brain cell body rind; adult head; and yolk nucleus. FBgn0037060 Alliance "Predicted to enable kinase binding activity and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of organ growth; regulation of DNA-templated transcription; and regulation of hippo signaling. Predicted to be active in cytoplasm. Is expressed in adult head." FBgn0028427 FlyBase Gene Snapshot "Integrin linked kinase (Ilk) encodes a pseudokinase that, together with the products of stck and parvin, mediates part of the adhesive functions of integrins." FBgn0004865 UniProtKB Induces the early late puff 78C which triggers puparium formation and development. (UniProtKB:P45447) FBgn0037061 UniProtKB "Acts as an activator of both RNA and protein methyltransferases (By similarity). Together with methyltransferase Mettl5, specifically methylates the 6th position of adenine in 18S rRNA (PubMed:32350990). (UniProtKB:Q9VP65)" FBgn0037059 Alliance Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in spermatozoon. FBgn0053056 Alliance "Predicted to enable ADP-ribosylglutamate hydrolase activity and purine nucleoside binding activity. Predicted to be involved in purine nucleoside metabolic process. Is expressed in several structures, including adult brain; adult pars intercerebralis; embryonic dorsal epidermis; embryonic esophagus; and embryonic hypopharynx." FBgn0053054 Alliance Predicted to enable ADP-ribosylglutamate hydrolase activity and purine nucleoside binding activity. Predicted to be involved in purine nucleoside metabolic process. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). FBgn0041100 FlyBase Gene Snapshot "parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion." FBgn0024150 FlyBase Gene Snapshot "Adenylyl cyclase 78C (Ac78C) encodes a member of the adenyly cyclase family of proteins. It converts adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. In taste receptor neurons, Ac78C product is involved in the sugar taste transduction pathway." FBgn0037051 Alliance "Predicted to enable Hsp70 protein binding activity and ribosome binding activity. Predicted to be involved in 'de novo' cotranslational protein folding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anal pad primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2)." FBgn0020294 Alliance "Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in motor neuron axon guidance. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including amnioproctodeal invagination; embryonic head epidermis; embryonic/larval central nervous system; embryonic/larval somatic muscle cell; and gut section. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to human STOX1 (storkhead box 1) and STOX2 (storkhead box 2)." FBgn0037045 Alliance "Predicted to enable protein methyltransferase activity. Predicted to be active in nucleus. Orthologous to human METTL22 (methyltransferase 22, Kin17 lysine)." FBgn0003415 FlyBase Gene Snapshot "skuld (skd) encodes a subunit of the kinase module of the mediator complex. It is not required for all the transcriptional functions of mediator, but links it to a set of transcription factors that are involved in developmental signaling." FBgn0053286 Alliance Predicted to enable beta-tubulin binding activity and microtubule binding activity. FBgn0053287 Alliance Predicted to enable beta-tubulin binding activity and microtubule binding activity. Is expressed in spermatozoon. FBgn0037040 Alliance Predicted to enable beta-tubulin binding activity and microtubule binding activity. Is expressed in organism. FBgn0037039 Alliance Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. FBgn0037038 Alliance Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0037036 FlyBase Gene Snapshot "Seminase (Sems) encodes a serine protease produced in male's accessory glands and transferred to females during mating. It is an essential component in the pathway for proteolytic processing of different seminal proteins. It cleaves the metalloprotease encoded by Semp1, which in turn also cleaves the seminal proteins encoded by Acp26Aa and Acp36DE. It is also required for sperm release from storage via regulation of the product of SP." FBgn0037068 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic posterior midline glial cell; embryonic ventral apodeme; and endoderm anlage." FBgn0037069 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis and embryonic ventral epidermis. FBgn0037071 Alliance Enables serine hydrolase activity. Is expressed in adult head and organism. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). FBgn0037073 UniProtKB Required during maturation of the 40S ribosomal subunit in the nucleolus. (UniProtKB:Q9VP47) FBgn0052436 FlyBase Gene Snapshot "CG32436 encodes a protein which contains five copies of a VTD-type deubiquitinase domain. It is most likely inactive, since crucial active site residues are missing." FBgn0053288 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. FBgn0005694 UniProtKB "Transcriptional repressor that binds specifically to fat body-specific enhancers, namely the adult ADH enhancer (AAE) and the enhancer that controls yolk protein gene expression. (UniProtKB:P39413)" FBgn0037087 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic/larval midgut primordium; embryonic/larval muscle system; gut section; and hindgut proper primordium. Orthologous to human PBDC1 (polysaccharide biosynthesis domain containing 1)." FBgn0037090 Alliance Enables serine hydrolase activity. FBgn0037092 FlyBase Gene Snapshot M6 (M6) encodes a four-transmembrane glycoprotein involved in eye morphogenesis and oogenesis. FBgn0037093 UniProtKB "Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. (UniProtKB:Q9VP22)" FBgn0037094 UniProtKB G-beta-like protein involved in cell signal transduction (By similarity). (UniProtKB:Q7K0L4) FBgn0053289 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). FBgn0015283 FlyBase Gene Snapshot Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. FBgn0028663 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including ATP6V0E2 (ATPase H+ transporting V0 subunit e2)." FBgn0037101 Alliance Is expressed in spermatozoon. FBgn0052438 FlyBase Gene Snapshot Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes. FBgn0052441 Alliance Part of EMC complex. Is expressed in adult head. Orthologous to human EMC10 (ER membrane protein complex subunit 10). FBgn0037102 FlyBase Gene Snapshot CR6-interacting factor (CRIF) encodes a protein that may play a role in regulating the RNAi pathway by stabilizing the RNAase III enzyme encoded by Dcr-2. FBgn0037099 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and spermatozoon. FBgn0037098 FlyBase Gene Snapshot "Wnk kinase (Wnk) encodes a chloride-sensitive Ser/Thr kinase that signals through a downstream target Ser/Thr kinase, encoded by fray, which is activated by phosphorylation the product of Wnk. Its roles include regulation of ion transport and cell growth, and differentiation and developmental patterning, including roles in canonical Wnt signaling and induction of the product of Awh." FBgn0029152 Alliance "Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in several processes, including positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis; and positive regulation of oskar mRNA translation. Part of ribonucleoprotein complex. Is active in P granule. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1) and MKRN4P (makorin ring finger protein 4, pseudogene)." FBgn0026371 FlyBase Gene Snapshot Sak kinase (SAK) encodes a serine/threonine protein kinase member of the Polo-like kinase family. It phosphorylates centrosomal proteins and self-regulates by autophosphorylation. It is required for centriole biogenesis and formation of the basal bodies of cilia and flagella. FBgn0015239 FlyBase Gene Snapshot Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle. FBgn0037085 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium." FBgn0014143 UniProtKB Required for the establishment of head structures. Required to function as an early patterning gene in the anterior-most blastoderm head segment anlage and for the establishment of a specific head skeletal structure that derives from the non-adjacent intercalary segment at a later stage of embryogenesis. Binds the consensus DNA sequence 5'-[AG]TAAA[TC]A-3'. (UniProtKB:P32027) FBgn0037081 Alliance Enables U2 snRNP binding activity. Involved in positive regulation of RNA splicing and regulation of neurogenesis. Predicted to be part of U2 snRNP and U2-type spliceosomal complex. Is expressed in organism. Orthologous to human HTATSF1 (HIV-1 Tat specific factor 1). FBgn0002842 FlyBase Gene Snapshot "spermatocyte arrest (sa) encodes a testis binding protein associated factor involved in control of the male meiotic cycle, gene expression regulation, and spermatid differentiation." FBgn0037076 FlyBase Gene Snapshot "earthbound 2 (ebd2) encodes a transcription cofactor with similar roles to the product of ebd1. It functions in the Wingless/Wnt pathway where it promotes the interaction of the products of arm and pan, and the recruitment of the product of arm to chromatin. The product of ebd2 functions in a context-specific manner and is important for the development of indirect flight muscles." FBgn0037074 Alliance Predicted to enable GTPase activator activity. Is expressed in adult head and spermatozoon. Used to study nephrotic syndrome type 20. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Orthologous to several human genes including TBC1D8 (TBC1 domain family member 8); TBC1D8B (TBC1 domain family member 8B); and TBC1D9 (TBC1 domain family member 9). FBgn0003042 FlyBase Gene Snapshot Polycomb (Pc) encodes a chromatin binding protein that interacts with histone H3K27me3. It is involved in epigenetic silencing and its target genes are predominantly transcription factors or receptors that control cell fate and most developmental decisions. FBgn0037070 Alliance Enables serine hydrolase activity. Is expressed in adult head. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). FBgn0037067 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0037065 Alliance Is expressed in adult head. FBgn0027945 UniProtKB The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity). (UniProtKB:Q9U616) FBgn0037064 Alliance Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human IMPA2 (inositol monophosphatase 2). FBgn0037063 Alliance Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. Is expressed in Bolwig organ; adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; intellectual disability; and schizophrenia. Orthologous to several human genes including IMPA2 (inositol monophosphatase 2). FBgn0037108 Alliance "Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; gland; and gut section. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Orthologous to human ALG11 (ALG11 alpha-1,2-mannosyltransferase)." FBgn0037110 UniProtKB Negative regulator of sphingolipid synthesis. (UniProtKB:Q9VP04) FBgn0043783 FlyBase Gene Snapshot Galactose mutarotase 1 (Galm1) encodes a putative enzyme that is predicted to catalyze the interconversion of beta-D-galactose and alpha-D-galactose. It is predicted to be involved in galactose metabolism. FBgn0052445 Alliance Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to be located in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase). FBgn0052446 FlyBase Gene Snapshot "Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body." FBgn0037115 Alliance Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. FBgn0037117 Alliance "Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; midline primordium; and ventral nerve cord primordium." FBgn0037121 Alliance "Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H)." FBgn0000560 FlyBase Gene Snapshot eagle (eg) encodes a transcription factor of the nuclear hormone receptor subfamily O. Its roles include serotonergic differentiation (in combination with the product of hkb) and axonal pathfinding. FBgn0022936 Alliance Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CCNH (cyclin H). FBgn0037134 Alliance Is expressed in organism. Orthologous to human MXRA7 (matrix remodeling associated 7). FBgn0037135 UniProtKB "Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (UniProtKB:Q9VNX8)" FBgn0037138 FlyBase Gene Snapshot "delta-1-Pyrroline-5-carboxylate dehydrogenase 1 (P5CDh1) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation." FBgn0046301 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in organism. FBgn0052448 Alliance Orthologous to human SMIM8 (small integral membrane protein 8). FBgn0037130 FlyBase Gene Snapshot "Syntrophin-like 1 (Syn1) encodes an adaptor protein associated with the Dystrophin glycoprotein complex that recruits different signaling components, including the product of Nos in neurons. Dystrophin-Syn1-neuronal Nos signaling via histone modifications regulates gene expression, including expression of miRNAs, and adapts cellular homeostasis, which is compromised under stress and dystrophic conditions." FBgn0037123 Alliance Is expressed in embryonic/larval posterior spiracle and posterior spiracle primordium. FBgn0037120 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; mesoderm; and sensory nervous system primordium." FBgn0052447 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. FBgn0037116 FlyBase Gene Snapshot Amyotrophic lateral sclerosis 2 (Als2) encodes a protein which when mutated results in age-dependent locomotion defects. FBgn0037114 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in wing disc. FBgn0037109 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9VP05)" FBgn0037107 Alliance Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in adult head. FBgn0037105 Alliance "Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1)." FBgn0037140 FlyBase Gene Snapshot "SLC22A family member (SLC22A) encodes a plasma membrane transporter and a member of the conserved family of SLC22A transporters. The product of SLC22A is preferentially localized in the dendrites of mushroom body neurons, where it functions to terminate synaptic transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine. Impairing the function of SLC22A enhances the acquisition and retention of olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent." FBgn0037142 Alliance Predicted to be part of BLOC-2 complex. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome and Hermansky-Pudlak syndrome 3. Orthologous to human HPS3 (HPS3 biogenesis of lysosomal organelles complex 2 subunit 1). FBgn0037144 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval somatic muscle cell; gut section; and visceral mesoderm derivative. Orthologous to human SLC22A1 (solute carrier family 22 member 1) and SLC22A3 (solute carrier family 22 member 3)." FBgn0029091 Alliance Predicted to enable chitin synthase activity. Predicted to be involved in chitin biosynthetic process. Predicted to be active in cell periphery and cell septum. FBgn0037146 Alliance Enables glutamate 5-kinase activity and glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in proline biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and yolk nucleus. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). FBgn0000045 UniProtKB "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (UniProtKB:P02574)" FBgn0004514 FlyBase Gene Snapshot "Octopamine-Tyramine receptor (Oct-TyrR) encodes a Tyramine 1 class receptor. When heterologously expressed it shows agonist specific coupling, with tyramine being more potent than octopamine in the inhibition of adenylyl cyclase activity and octopamine being more potent than tyramine in the release of calcium from internal stores." FBgn0037149 Alliance "Is expressed in several structures, including antennal primordium; central brain primordium; head epidermis primordium; ventral nerve cord primordium; and visual primordium." FBgn0000100 UniProtKB Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (UniProtKB:P19889) FBgn0004414 FlyBase Gene Snapshot male-specific opa containing gene (msopa) encodes a peptide produced by male accessory glands and transferred to females during mating. FBgn0027532 Alliance Predicted to enable DNA endonuclease activity. Is expressed in organism. Orthologous to human N4BP2 (NEDD4 binding protein 2). FBgn0037147 Alliance "Predicted to enable glucose-6-phosphate dehydrogenase activity. Predicted to be involved in glucose metabolic process and pentose-phosphate shunt, oxidative branch. Predicted to be active in cytosol." FBgn0037141 FlyBase Gene Snapshot DNA polymerase eta (PolH) encodes a member of the Y-family of DNA translesion polymerases. It operates during the bypass of UV-induced lesions and possibly during homologous recombination repair of DNA double-strand breaks. FBgn0052449 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0015075 FlyBase Gene Snapshot "Dead-box-1 (Ddx1) encodes a member of the DEAD box family of RNA helicases that bind and unwind double-stranded RNA. Ddx1 product depletion is associated with small size and aberrant gametogenesis, possibly through alternative splicing of Sirup RNA transcript." FBgn0004179 FlyBase Gene Snapshot "Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively." FBgn0025702 FlyBase Gene Snapshot Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. FBgn0027086 Alliance "Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and mesoderm. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1)." FBgn0052450 Alliance Is expressed in adult head. FBgn0037162 Alliance Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFAP45 (cilia and flagella associated protein 45). FBgn0037164 Alliance Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be active in plasma membrane. Is expressed in embryonic dorsal epidermis; embryonic foregut; embryonic head epidermis; and embryonic ventral epidermis. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3). FBgn0037165 Alliance Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; and embryonic/larval corpus cardiacum. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3). FBgn0037166 Alliance "Predicted to enable phosphatidate phosphatase activity. Involved in phototransduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including CNS glial cell; embryonic head sensory system; embryonic optic lobe primordium; embryonic/larval nervous system; and sensory nervous system primordium. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3)." FBgn0037167 Alliance Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3). FBgn0037163 FlyBase Gene Snapshot "lazaro (laza) encodes a protein involved in phototransduction, response to light intensity and thermotaxis." FBgn0004449 FlyBase Gene Snapshot "Tenascin major (Ten-m) encodes a type II dimeric transmembrane protein whose extracellular domain mediates interactions with itself and with its paralogous protein encoded by Ten-a. It also interacts intracellularly with cytoskeleton regulatory proteins. Ten-m product regulates synaptic partner matching and axon guidance in the embryonic nervous system, as well as synaptic organization in olfactory and neuromuscular systems." FBgn0011771 FlyBase Gene Snapshot "HEM-protein (Hem) encodes a component of the WAVE Regulatory Complex. Hem product regulates processes such as neuronal migration and asymmetric division of neural precursors by inhibiting the product of SCAR degradation. In the asymmetric process, the Hem-pathway indirectly maintains proper localization of proteins such as those encoded by insc and numb." FBgn0037156 Alliance Predicted to enable kinase regulator activity and protein kinase A binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasm. Is expressed in embryonic/larval muscle system; embryonic/larval somatic muscle cell; and organism. Orthologous to human GSKIP (GSK3B interacting protein). FBgn0028500 UniProtKB "Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses. (UniProtKB:Q9V3C5)" FBgn0037170 FlyBase Gene Snapshot "Thioredoxin reductase 2 (Trxr2) encodes a homodimeric form of enzyme, which catalyzes NADPH-dependent reduction of the product of Trxr1, which protects the cell from oxidative stress." FBgn0037172 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Orthologous to human NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7)." FBgn0037174 Alliance Predicted to be active in extracellular space. FBgn0037176 Alliance "Involved in imaginal disc fusion, thorax closure." FBgn0037179 Alliance Is expressed in embryonic/larval salivary gland. FBgn0037180 Alliance Is expressed in organism. FBgn0037181 Alliance Is expressed in embryonic/larval posterior spiracle; embryonic/larval tracheal dorsal trunk; midline primordium; tracheal dorsal trunk primordium; and ventral midline of embryo. FBgn0052452 Alliance Is expressed in organism. FBgn0037185 Alliance Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut interstitial cell; and organism. Orthologous to human TMEM64 (transmembrane protein 64). FBgn0260481 Alliance Predicted to enable manganese ion binding activity. Predicted to be active in mitochondrion. FBgn0037188 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; ganglia; and pole plasm. Orthologous to several human genes including RASGEF1B (RasGEF domain family member 1B)." FBgn0052451 FlyBase Gene Snapshot Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis. FBgn0037191 Alliance Is expressed in spermatozoon. FBgn0010830 Alliance "Is expressed in several structures, including antennal anlage; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm." FBgn0037186 Alliance "Predicted to enable alanine-glyoxylate transaminase activity. Predicted to be involved in L-alanine catabolic process, by transamination and glyoxylate catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; epithelial tube; gut section; and mesoderm. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2)." FBgn0037184 Alliance "Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription. Predicted to be active in mitochondrial nucleoid. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial)." FBgn0037182 FlyBase Gene Snapshot "ADP-ribosylation factor GTPase activating protein 3 (ArfGAP3) a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye." FBgn0053169 Alliance Is expressed in adult head. Orthologous to human SMCO4 (single-pass membrane protein with coiled-coil domains 4). FBgn0037200 Alliance Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in RNA methylation and tRNA modification. Is expressed in organism and spermatozoon. Used to study syndromic intellectual disability. Orthologous to human NSUN6 (NOP2/Sun RNA methyltransferase 6). FBgn0037202 Alliance "Predicted to enable zinc ion binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human GTF2H2C (GTF2H2 family member C); GTF2H2C_2 (GTF2H2 family member C, copy 2); and GTF2H2 (general transcription factor IIH subunit 2)." FBgn0037203 Interactive Fly Amino acid transporter - downregulation within the fat body causes a global growth defect involving TSC/TOR signaling in the fat body and a remote inhibition of organismal growth FBgn0037204 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0037205 FlyBase Gene Snapshot "Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells." FBgn0037206 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in amnioserosa and amnioserosa primordium. FBgn0037207 FlyBase Gene Snapshot Mesoderm-expressed 2 (Mes2) encodes a transcription regulator involved in ecdysis. FBgn0052457 Alliance Is expressed in testis. FBgn0044324 FlyBase Gene Snapshot "Chromator (Chro) encodes a chromodomain protein that is required for proper microtubule spindle formation. It is important for normal cell cycle progression, functioning as a spatial regulator of cell cycle factors." FBgn0010348 UniProtKB "Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Has a role in eye development (PubMed:21976699). Required for cleavage furrow ingression in embryonic cells (PubMed:27535433). (UniProtKB:P61209)" FBgn0020518 FlyBase Gene Snapshot C/D box small nucleolar RNA 1 (snoRNA:CD1) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G789 in 28SrRNA:CR45844. FBgn0037199 Alliance Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Part of EMC complex. Is expressed in adult head; adult heart; and organism. Orthologous to human EMC4 (ER membrane protein complex subunit 4). FBgn0052462 FlyBase Gene Snapshot "CG32462 encodes a protein which contains a VTD-type deubiquitinase domain. It is most likely inactive, since crucial active site residues are missing." FBgn0052460 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0046878 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in embryonic/larval fat body and labellar taste bristle. FBgn0037402 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). (UniProtKB:Q9VNL3)" FBgn0037405 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. Predicted to be active in extracellular region. FBgn0037406 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0037408 UniProtKB "Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference. (UniProtKB:Q9VNM1)" FBgn0037409 Alliance "Predicted to be active in membrane. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0037410 Alliance "Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; epidermis; and gut section." FBgn0037411 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in embryonic dorsal epidermis and embryonic ventral epidermis. FBgn0037413 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0027527 Alliance Located in endomembrane system. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic hypopharynx; embryonic ventral epidermis; and gut section. FBgn0037414 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in embryonic dorsal epidermis; embryonic esophagus; embryonic hypopharynx; and embryonic ventral epidermis. FBgn0037415 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in trichoid sensillum of antennal segment 3. FBgn0037416 Alliance Involved in open tracheal system development. Located in endosome membrane. Is expressed in embryonic esophagus; embryonic salivary gland duct; embryonic/larval posterior spiracle; and epithelial tube. FBgn0037419 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic/larval posterior spiracle; embryonic/larval salivary gland common duct; and larval foregut atrium. FBgn0037422 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0040279 Alliance "Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including adult heart; embryonic anal pad; embryonic head epidermis; epidermis; and gut section." FBgn0037424 Alliance Involved in open tracheal system development. Located in endosome membrane. Is expressed in adult head; embryonic/larval posterior spiracle; and embryonic/larval tracheal section. FBgn0051561 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0037427 Alliance "Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0037428 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in embryonic/larval tracheal dorsal trunk; embryonic/larval tracheal section; embryonic/larval tracheal system; and embryonic/larval tracheal transverse connective. FBgn0037418 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0037412 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0051559 Alliance Predicted to be involved in sensory perception of sound. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic hypopharynx; embryonic ventral epidermis; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1). FBgn0046875 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. FBgn0046876 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. FBgn0026077 FlyBase Gene Snapshot Gasp (Gasp) encodes a protein involved in cuticle biosynthesis during embryonic tracheal system development. FBgn0037399 FlyBase Gene Snapshot "Odorant receptor 83c (Or83c) encodes a member of the odorant receptor family of ligand-gated ion channels. It confers sensitivity to farnesol, a fruit rind volatile present in many ripe citrus rinds." FBgn0037396 Alliance Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Orthologous to human CTSH (cathepsin H). FBgn0037374 FlyBase Gene Snapshot jagunal (jagn) encodes a conserved protein that is located in the endoplasmic reticulum membrane. It contributes to oocyte growth by organizing the endoplasmic reticulum. It is also involved in bristle growth. FBgn0037375 FlyBase Gene Snapshot katanin p60-like 1 (kat-60L1) encodes a microtubule-severing protein that regulates dendrite morphogenesis. FBgn0028690 Alliance "Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12)." FBgn0037377 UniProtKB Cofactor for serine ADP-ribosylation that confers serine specificity on Parp. Switches the amino acid specificity of Parp from aspartate or glutamate to serine residues. Acts by completing the active site of Parp: forms a composite active site composed of residues from HPF1/CG1218 and Parp. (UniProtKB:Q9VNI3) FBgn0037379 Alliance "Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; ganglia; germline cell; and mesoderm. Orthologous to human ZNF800 (zinc finger protein 800)." FBgn0037384 FlyBase Gene Snapshot "degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics." FBgn0037386 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). FBgn0037387 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and adult heart. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). FBgn0028436 UniProtKB Involved in the innate immune response. Promotes the production of antibacterial peptides. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. (UniProtKB:Q9U6M0) FBgn0037395 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ASTL (astacin like metalloendopeptidase). FBgn0003261 UniProtKB "As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, rRNA processing and miRNA processing, as well as transcription regulation (By similarity) (PubMed:12368261). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). (UniProtKB:P19109)" FBgn0010403 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in antennal sense organ; eo sensory organ accessory cell; and organism subdivision. FBgn0011281 Alliance Predicted to enable pheromone binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in antennal sense organ; eo sensory organ accessory cell; and organism subdivision. FBgn0037391 Alliance Predicted to enable GTP binding activity; alpha-aminoacyl-tRNA binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Used to study syndromic intellectual disability. Orthologous to human GTPBP2 (GTP binding protein 2). FBgn0029088 FlyBase Gene Snapshot "dispatched (disp) encodes a multipass transmembrane protein and a member of the RND transporter family. It is required for the release and long-range activity of the lipid-modified product of hh from producing cells. The products of hh and disp control cell growth, survival, fate, and patterning." FBgn0037383 Alliance Predicted to enable SNAP receptor activity. Involved in regulation of autophagy and regulation of vesicle-mediated transport. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and adult heart. Orthologous to human BNIP1 (BCL2 interacting protein 1). FBgn0037382 Alliance Involved in mRNA export from nucleus in response to heat stress. Located in nucleus. Part of THO complex. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). FBgn0037378 Alliance Predicted to enable proteasome binding activity. Predicted to be involved in proteasome core complex assembly. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; adult heart; and organism. FBgn0037376 FlyBase Gene Snapshot Histone acetyltransferase 1 (Hat1) encodes a B-type histone acetyltransferase that localizes to both the cytoplasm and the nucleus. It is involved in the escort machinery of newly synthesized histones encoded by His3 and His4 to chromatin and acetylates the product of His4 at lysines 5 and 12. It also forms a complex with centromeric histone encoded by cid and is involved in cid chromatin assembly. FBgn0037372 Alliance "Predicted to enable 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity and RNA 7-methylguanosine cap binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA. Predicted to be active in P-body and nucleus. Is expressed in organism. Orthologous to human DCPS (decapping enzyme, scavenger)." FBgn0037329 Alliance Predicted to enable DNA binding activity. Predicted to be involved in error-free translesion synthesis. Predicted to be active in mitochondrial nucleoid and nucleus. Is expressed in adult head; adult heart; and embryonic/larval midgut. Orthologous to human POLDIP2 (DNA polymerase delta interacting protein 2). FBgn0011715 FlyBase Gene Snapshot Snf5-related 1 (Snr1) encodes a core component of the ATP-dependent SWI/SNF chromatin-remodeling complex (Brahma complex). It functions as a tumor suppressor and is required for maintaining normal endosomal trafficking-mediated signaling cascades. FBgn0037332 FlyBase Gene Snapshot "Holocarboxylase synthetase (Hcs) encodes a biotin protein ligase that contributes to gluconeogenesis, fatty acid synthesis and amino acid catabolism." FBgn0051550 Alliance Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to be active in nucleoplasm. Is expressed in organism. Orthologous to human SUGP1 (SURP and G-patch domain containing 1). FBgn0010051 FlyBase Gene Snapshot "Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight." FBgn0037338 Alliance Predicted to enable 5'-3' DNA exonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and interstrand cross-link repair. Is expressed in organism and spermatozoon. Orthologous to human DCLRE1A (DNA cross-link repair 1A). FBgn0037341 Alliance "Predicted to enable diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation and phospholipid metabolic process. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic large intestine; embryonic/larval posterior spiracle; and gut section. Orthologous to human PLPP4 (phospholipid phosphatase 4) and PLPP5 (phospholipid phosphatase 5)." FBgn0041191 FlyBase Gene Snapshot "Ras homolog enriched in brain (Rheb) encodes a Ras homolog that is the target of the product of gig. It activates the protein kinase encoded by mTor, leading to enlarged cell size." FBgn0037345 UniProtKB "As the accessory component of the DNA polymerase zeta complex, involved in translesion DNA synthesis (TLS) and various DNA repair mechanisms (PubMed:15175013, PubMed:16507570). Promotes the apurinic/apyrimidinic (AP) endonuclease activity of Rrp1 and is therefore likely to be involved in the base excision repair (BER) pathway responsible for repair of DNA lesions (PubMed:16507570). It does not appear to influence the synthesis activity of the catalytic component Dmpol-zeta (PubMed:15175013). (UniProtKB:Q9VNE1)" FBgn0037347 Alliance Predicted to enable tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Is expressed in embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). FBgn0019637 Alliance "Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in regulation of hemocyte proliferation. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)." FBgn0037351 FlyBase Gene Snapshot "Ribosomal protein L13A (RpL13A) encodes a component of the large ribosomal subunit, and thus involved in mRNA translation. Mutations in genes encoding ribosomal proteins affect fertility, viability and other Drosophila phenotypes, described as Minute." FBgn0051549 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Is expressed in adult head and organism. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). FBgn0037354 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Is expressed in adult head and organism. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). FBgn0037356 Alliance "Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial)." FBgn0037359 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene. (UniProtKB:Q9VNG0)" FBgn0046222 Alliance "Predicted to be involved in mRNA 3'-end processing. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study primary ovarian insufficiency. Orthologous to human WDR33 (WD repeat domain 33)." FBgn0037363 FlyBase Gene Snapshot "Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan." FBgn0037368 UniProtKB Probable RNA methyltransferase. (UniProtKB:Q9VNH1) FBgn0037370 Alliance "Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; gland; hindgut proper primordium; and salivary gland body primordium. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase)." FBgn0027497 UniProtKB May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus. (UniProtKB:Q9Y0Y6) FBgn0037371 FlyBase Gene Snapshot "Symplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia." FBgn0037369 Alliance "Predicted to enable CCA tRNA nucleotidyltransferase activity and tRNA binding activity. Predicted to be involved in mitochondrial tRNA 3'-end processing and tRNA 3'-terminal CCA addition. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1)." FBgn0004878 FlyBase Gene Snapshot "castor (cas) encodes a transcription factor expressed in the latest stage of embryonic neuroblast lineages. It represses the prior redundant genes, pdm2 nub, and precedes the expression of grh." FBgn0037365 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). FBgn0037364 FlyBase Gene Snapshot "Rab23 (Rab23) encodes a member of the Rab family of small GTPases known to be involved in vesicle transport processes. It cooperates with the product of in and the core group of planar cell polarity genes. It contributes to restricting actin accumulation and thus, prehair initiation to a single site within each wing cell, and to regulate the number and orientation of hairs on the leg and the abdominal cuticle. In addition, it regulates the trafficking of the ligand encoded by hh in the germline stem cell niche." FBgn0010772 FlyBase Gene Snapshot Xe7 (Xe7) encodes a protein that contributes to axon guidance and lateral inhibition. FBgn0037360 Alliance Predicted to be active in cytoplasm and nucleus. Orthologous to human GGNBP2 (gametogenetin binding protein 2). FBgn0037358 Alliance "Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of phospholipid biosynthetic process. Located in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; ganglia; mesoderm; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to several human genes including CHP1 (calcineurin like EF-hand protein 1)." FBgn0027951 Alliance Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromosome condensation. Located in nucleoplasm. Part of NuRD complex. Is expressed in adult brain cell body rind; organism; primordial germ cell; and spermatozoon. Orthologous to several human genes including MTA1 (metastasis associated 1). FBgn0051548 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Is expressed in adult head and adult heart. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). FBgn0051546 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Is expressed in spermatozoon. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). FBgn0044823 UniProtKB "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. (UniProtKB:Q9VNE7)" FBgn0037350 Alliance Predicted to enable ATPase activator activity. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). FBgn0017550 UniProtKB "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:20504953, PubMed:23303381). Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:23303381). Essential for viability (PubMed:9475742). Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes (PubMed:9475742). Plays a role in germline stem cell differentiation in the ovaries (PubMed:29887366). (UniProtKB:Q94547)" FBgn0014366 UniProtKB Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility. (UniProtKB:O46106) FBgn0037344 Alliance "Predicted to enable zinc ion binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Orthologous to human PHRF1 (PHD and ring finger domains 1)." FBgn0037342 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human RBM42 (RNA binding motif protein 42)." FBgn0037340 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human CCDC115 (coiled-coil domain containing 115). FBgn0037339 FlyBase Gene Snapshot Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland. FBgn0037336 Alliance Is expressed in adult head. FBgn0010399 UniProtKB "NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (UniProtKB:Q24418)" FBgn0051547 Alliance "Predicted to enable amino acid transmembrane transporter activity and sodium:potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Is expressed in several structures, including adult brain; anal pad; anterior-posterior subdivision of organism; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3)." FBgn0015402 FlyBase Gene Snapshot kinase suppressor of ras (ksr) encodes a MAP-kinase scaffold protein. It mediates the activation of the serine/threonine kinase encoded by Dsor1. FBgn0025825 FlyBase Gene Snapshot Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid. FBgn0037330 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translational elongation. Predicted to be part of microprocessor complex and mitochondrial large ribosomal subunit. Predicted to be active in nucleus. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44)." FBgn0037328 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit biogenesis. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). FBgn0037327 FlyBase Gene Snapshot pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress. FBgn0037295 Alliance Involved in synapse organization. Predicted to be located in extracellular region. Predicted to be active in neuron projection membrane. FBgn0037297 Alliance "Predicted to enable small GTPase binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Located in Golgi apparatus. Is expressed in organism. Orthologous to human RGP1 (RGP1 homolog, RAB6A GEF complex partner 1)." FBgn0037299 Alliance Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Is expressed in organism. Orthologous to several human genes including VPS37B (VPS37B subunit of ESCRT-I). FBgn0037301 UniProtKB "Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (By similarity). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). Essential for diploid cell cycles, organ growth and development (PubMed:29361561). Regulates mitosis by binding to Xpd and thereby competing with the Xpd-mediated repression on the Cdk-activating kinase (CAK) complex (PubMed:29361561). Regulates the centrosomal localization of the MT regulator tacc, a downstream target of aurA kinase (PubMed:33211700). Binds to microtubules (MT) (PubMed:33211700). Regulates spindle and astral MT growth, MT stability and bundling (PubMed:33211700). In neuroblasts, necessary for timely and coordinated spindle assembly and orientation which is necessary for mitotic progression (PubMed:33211700). In young embryos, the maternal protein is important for progression through mitosis (PubMed:29361561). (UniProtKB:Q95U54)" FBgn0037304 Alliance Human ortholog(s) of this gene implicated in retinitis pigmentosa 28. Orthologous to human FAM161A (FAM161 centrosomal protein A) and FAM161B (FAM161 centrosomal protein B). FBgn0037310 UniProtKB "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (UniProtKB:Q9VNA0)" FBgn0051542 Alliance Is expressed in organism and spermatozoon. FBgn0003275 FlyBase Gene Snapshot "RNA polymerase II, I and III subunit F (Polr2F) encodes a shared subunit of RNA polymerases I, II, and III." FBgn0011965 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037325 Alliance "Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1)." FBgn0037324 FlyBase Gene Snapshot "Odorant receptor co-receptor (Orco) encodes a broadly expressed in the chemosensory organs, where it forms heteromultimeric complexes with ligand-selective odorant receptors (ORs). It serves dual role as a chaperone for cell surface expression of the OR/Orco complex as well as being integral to the function of the olfactory receptor complex. It does not itself respond to olfactory ligands, but is thought to contribute to the putative ion-conducting pore." FBgn0037323 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head and embryonic/larval tracheal section. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0037322 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentanol, ethyl acetate, and propyl acetate. (UniProtKB:Q9VNB3)" FBgn0001311 FlyBase Gene Snapshot "krotzkopf verkehrt (kkv) encodes a membrane-inserted glycosyltransferase family 2 chitin synthase that uses GlcNAc to produce the polysaccharide chitin, which is extruded to the differentiating cuticle and tracheal system (tracheal cuticle, tube diameter regulation and gas filling)." FBgn0037315 FlyBase Gene Snapshot "Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration." FBgn0037312 Alliance Predicted to enable misfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including SDF2L1 (stromal cell derived factor 2 like 1). FBgn0051538 Alliance Is expressed in adult head. FBgn0037307 UniProtKB "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (UniProtKB:Q9VN97)" FBgn0037305 UniProtKB "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (UniProtKB:Q9VN95)" FBgn0260462 UniProtKB May have a role in autophagic cell death. (UniProtKB:Q9VN93) FBgn0040208 FlyBase Gene Snapshot "Katanin 60 (Kat60) encodes a microtubule depolymerase involved in multiple microtubule-related processes including chromatid segregation, cell migration and dendrite development." FBgn0037298 Alliance Predicted to be involved in glycolipid biosynthetic process. Predicted to be active in lipid droplet. Is expressed in adult head; adult heart; and organism. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). FBgn0037296 Alliance "Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10) and PSMB7 (proteasome 20S subunit beta 7)." FBgn0004913 FlyBase Gene Snapshot Germ line transcription factor 1 (Gnf1) encodes the largest subunit of the replication factor C (RFC). RFC is a clamp loader that loads a sliding clamp (PCNA) trimer to the DNA replication fork. FBgn0037290 Alliance Predicted to be active in extracellular space. Is expressed in adult fat body; adult head; ganglia; glial cell; and ventral midline of embryo. FBgn0037293 Alliance Contributes to Rab geranylgeranyltransferase activity. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in organism. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). FBgn0010313 FlyBase Gene Snapshot "corto (corto) encodes an Enhancer of Trithorax and Polycomb (ETP) protein that physically interacts with several Polycomb proteins (encoded by Pc, ph-d, ph-p, esc, E(z)) and ETP (encoded by Trl, Dsp1). It also interacts with the product of CycG, with the methylated product of RpL12 (RPL12K3me3), and co-regulates the transcription of genes involved in ribosome biogenesis." FBgn0037292 Alliance Predicted to enable monoatomic ion channel activity. Involved in response to hypoxia. Predicted to be located in membrane. Predicted to be active in mitochondrion. FBgn0037288 Alliance Predicted to be active in extracellular space. FBgn0004436 FlyBase Gene Snapshot Ubiquitin conjugating enzyme 6 (Ubc6) encodes an enzyme that acts together with E3 ubiquitin ligases to transfer ubiquitin to target proteins. FBgn0004183 Alliance Predicted to enable pre-mRNA 5'-splice site binding activity. Involved in chromatin organization. Predicted to be part of U1 snRNP. FBgn0037262 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene. (UniProtKB:Q8IH24)" FBgn0037263 FlyBase Gene Snapshot "nuclease slx1 (slx1) encodes the catalytic subunit of a DNA endonuclease, which cuts specific branched structures during DNA repair." FBgn0022981 FlyBase Gene Snapshot ripped pocket (rpk) encodes a sodium channel in the Degenerin/Epithelial Sodium Channel/Acid Sensing Ion Channel (Deg/ENaC/ASIC) family. Expression of rpk in the larval multidendritic neurons is required for the detection of gentle touch stimuli. FBgn0037265 FlyBase Gene Snapshot "spartin (spartin) encodes a multi-functional protein associated with organelle membranes, including endosomes, lipid droplets, and mitochondria. It participates in cytokinesis, BMP receptor trafficking, lipid droplet turnover, and mitochondrial Ca[2+] homeostasis." FBgn0010750 FlyBase Gene Snapshot "antimeros (atms) encodes a component of the PAF1 complex (together with the products of Atu, hyx, Rtf1 and Ctr9). The PAF1 complex physically interacts with components of the basal transcription machinery and sequence-specific transcription factors to control histone modifications and pause release." FBgn0037279 FlyBase Gene Snapshot "GDP-mannose pyrophosphorylase B (Gmppb) encodes a putative enzyme that is predicted to catalyze the formation of GDP-mannose, a precursor for protein N-glycosylation." FBgn0037280 Alliance Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in cilium assembly. Predicted to be part of BBSome. Predicted to be active in ciliary basal body. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 5. Orthologous to human BBS5 (Bardet-Biedl syndrome 5). FBgn0037282 Alliance Is expressed in dorsal ectoderm anlage; gonad; organism; and ventral ectoderm anlage. FBgn0026417 FlyBase Gene Snapshot Hus1-like (Hus1-like) encodes a protein that together with proteins encoded by Rad1 and Rad9 form the 9-1-1 checkpoint protein complex. This complex plays a central role in the DNA damage-induced checkpoint response. FBgn0037276 Alliance Predicted to be involved in cilium-dependent cell motility; epithelial cilium movement involved in determination of left/right asymmetry; and inner dynein arm assembly. Predicted to be active in axoneme. Is expressed in adult head; chordotonal neurons; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 14. Orthologous to human CCDC39 (coiled-coil domain 39 molecular ruler complex subunit). FBgn0037275 FlyBase Gene Snapshot "CG14655 encodes a protein that is thought to have a role during muscle development, specifically in the morphogenesis of myofibrils in flight muscles." FBgn0027570 UniProtKB "Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706). (UniProtKB:A0A0B4K692)" FBgn0037270 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q9VN50)" FBgn0040466 Alliance Is expressed in organism. FBgn0037261 Alliance Is expressed in adult head and organism. FBgn0052945 Alliance Is expressed in adult head. FBgn0027930 FlyBase Gene Snapshot "Melanization Protease 1 (MP1) encodes a serine protease which plays an essential role in the melanization immune response, by acting downstream of Sp7 to activate PPO1. It may function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins: Spn27A in the hemolymph and Spn77Ba in the trachea." FBgn0037232 UniProtKB "Major helicase player in mitochondrial RNA metabolism and maintenance (PubMed:26152302). Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (By similarity). Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts (PubMed:26152302). (UniProtKB:Q9VN03)" FBgn0040687 Alliance Predicted to enable chitin binding activity. FBgn0037235 Alliance "Is expressed in several structures, including anterior endoderm; embryonic epipharynx; embryonic hypopharynx; endoderm anlage; and gut section. Human ortholog(s) of this gene implicated in Usher syndrome type 3A; autosomal recessive nonsyndromic deafness; and retinitis pigmentosa 61. Orthologous to human CLRN1 (clarin 1); CLRN2 (clarin 2); and CLRN3 (clarin 3)." FBgn0037238 UniProtKB May function in the removal and maintenance of calcium homeostasis. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). (UniProtKB:Q9VN12) FBgn0037239 UniProtKB Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. (UniProtKB:Q9VN13) FBgn0037240 FlyBase Gene Snapshot Contactin (Cont) encodes a GPI-anchored cell adhesion molecule. It interacts with the product of Nrx-IV in cis to organize septate junctions in epithelial cells and also between ensheathing glial cells and neurons. FBgn0003882 FlyBase Gene Snapshot "tube (tub) encodes an adaptor protein, which functions downstream of the product of Myd88 in the Toll pathway. Toll pathway is a signaling cascade that plays a key role in various developmental and immune processes, notably embryonic dorsoventral patterning and regulation of antimicrobial peptides." FBgn0037241 Alliance "Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)." FBgn0037244 Alliance Predicted to be involved in protein homooligomerization. Is expressed in organism. Orthologous to human KCTD9 (potassium channel tetramerization domain containing 9). FBgn0051528 Alliance Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Orthologous to human UBQLN3 (ubiquilin 3) and UBQLNL (ubiquilin like). FBgn0037250 Alliance "Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; embryonic/larval muscle system; gut section; and trunk mesoderm. Orthologous to human TRMT11 (tRNA methyltransferase 11 homolog)." FBgn0037252 Alliance Is expressed in adult head. Orthologous to human DNAJC14 (DnaJ heat shock protein family (Hsp40) member C14). FBgn0037254 FlyBase Gene Snapshot "sterile affecting ciliogenesis (sac) encodes a component of the flagellar axoneme that is required for ciliogenesis and cytokinesis during spermatogenesis. When mutated, it results in male sterility with immotile flagella and disrupted localization of subcellular structures." FBgn0037255 Alliance Enables myosin binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in nucleus. Orthologous to human FIP1L1 (factor interacting with PAPOLA and CPSF1). FBgn0037260 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in organism. FBgn0051523 Alliance "Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; primary segmental tracheal branch primordium; and primary tracheal branch. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7)." FBgn0051522 Alliance "Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic dorsal epidermis; embryonic ventral epidermis; and embryonic/larval midgut primordium. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7)." FBgn0037251 UniProtKB Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). (UniProtKB:Q9VN27) FBgn0037249 UniProtKB "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q9VN25)" FBgn0037248 Interactive Fly "transcriptional coactivator - required for the expression of multiple genes encoding mitochondrial proteins - mediates mitochondrial activity, cell growth and transcription of target genes in response to insulin signalling" FBgn0052944 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Orthologous to human STK32A (serine/threonine kinase 32A); STK32B (serine/threonine kinase 32B); and STK32C (serine/threonine kinase 32C). FBgn0037242 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein polyubiquitination and regulation of mitochondrial fission. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). FBgn0037236 FlyBase Gene Snapshot S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. FBgn0037231 FlyBase Gene Snapshot "Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding." FBgn0037230 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head and embryonic/larval fat body. FBgn0037213 Alliance "Is expressed in several structures, including adult head; antennal primordium; epithelium; gut section; and head epidermis primordium." FBgn0037215 Alliance "Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval salivary gland body; and salivary gland body primordium. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta)." FBgn0037218 FlyBase Gene Snapshot "auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death." FBgn0015331 FlyBase Gene Snapshot "abstrakt (abs) encodes a protein that belongs to the DEAD/DEAH box helicase family. It is involved in the post-transcriptional regulation of insc levels and affects cell polarity, asymmetric cell divisions, axon outgrowth and fasciculation." FBgn0010225 UniProtKB "Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. (UniProtKB:Q07171)" FBgn0037224 Alliance A structural constituent of chitin-based larval cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0037227 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0041621 FlyBase Gene Snapshot Odorant receptor 82a (Or82a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0037228 Alliance Is expressed in embryonic/larval fat body; embryonic/larval plasmatocyte; and plasmatocyte primordium. FBgn0037229 Alliance Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. FBgn0037225 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0037220 Alliance "Predicted to enable U6 snRNA binding activity; mRNA binding activity; and pre-mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; mesoderm; and posterior endoderm. Orthologous to human RBM22 (RNA binding motif protein 22)." FBgn0037217 Alliance "Involved in sensory perception of sound. Is expressed in several structures, including embryonic central brain neurons; embryonic head epidermis; embryonic ventral epidermis; epidermis; and gut section." FBgn0000500 UniProtKB "Involved in diverse biological roles including regulating aspects of gut function, satiety and food ingestion, hyperactivity, and aggression (PubMed:17632121, PubMed:24142897, PubMed:25187989). Regulates gut muscle contraction in adults but not in larvae (PubMed:17632121). Functions downstream of TfAP-2 and twz in octopamine signaling pathways to modulate feeding and male aggression (PubMed:24142897, PubMed:25187989). Inhibits consummatory behavior in adults and functions as part of a negative feedback loop with TfAP-2 and twz to prevent overeating; TfAP-2 and twz regulate octopamine signaling to initiate feeding, then octopamine activates expression of Dsk in insulin-producing cells (IPCs) to inhibit feeding (PubMed:25187989). (UniProtKB:P09040)" FBgn0031670 UniProtKB Probably has thioredoxin reductase-like oxidoreductase activity. (UniProtKB:Q9VMV6) FBgn0000299 FlyBase Gene Snapshot Collagen type IV alpha 1 (Col4a1) encodes a subunit of Collagen IV and a major component of basement membranes. It is required for muscle and epithelium integrity. FBgn0260470 Alliance "Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; ganglia; and sensory nervous system primordium." FBgn0031676 UniProtKB "UDP-galactose transporter involved in the synthesis of galactose-containing glycans. Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz. (UniProtKB:Q9VMU8)" FBgn0031682 Alliance "Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryonic/larval crystal cell; embryonic/larval midgut; posterior endoderm; somatic precursor cell; and yolk nucleus. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive))." FBgn0031683 Alliance "Predicted to be involved in negative regulation of apoptotic process and regulation of actin filament polymerization. Predicted to be active in several cellular components, including apical plasma membrane; clathrin-coated vesicle; and sarcoplasmic reticulum. Is expressed in several structures, including adult head; antennal primordium; central brain primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1)." FBgn0031684 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in cervical cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6)." FBgn0031681 FlyBase Gene Snapshot Polypeptide N-Acetylgalactosaminyltransferase 5 (Pgant5) encodes a member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family and catalyzes the transfer of a GalNAc sugar onto the hydroxyl groups of serine and threonine in secreted or membrane-bound proteins. The product of Pgant5 is essential and affects digestive system acidification. FBgn0028694 UniProtKB Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (UniProtKB:Q9V3H2) FBgn0031678 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in nurse cell; organism; and spermatozoon. FBgn0031677 Alliance Involved in copper ion homeostasis. Is expressed in organism. FBgn0022023 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q9U9Q4)" FBgn0031675 Alliance Predicted to be active in cytoplasm. Orthologous to several human genes including GPR75-ASB3 (GPR75-ASB3 readthrough); ASB14 (ankyrin repeat and SOCS box containing 14); and ASB15 (ankyrin repeat and SOCS box containing 15). FBgn0031673 Alliance "Predicted to enable calcium ion binding activity. Located in endoplasmic reticulum. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; ventral midline of embryo; and ventral nerve cord primordium. Orthologous to human RCN2 (reticulocalbin 2)." FBgn0016075 FlyBase Gene Snapshot viking (vkg) encodes a subunit of Collagen IV and a major component of basement membranes. It is secreted by haemocytes and fat body cells and is required for the normal morphogenesis of many tissues. It also contributes to TGF-beta signalling in the early embryo and the developing Malpighian tubules. FBgn0031668 Alliance "Predicted to enable nucleosome binding activity. Involved in chromatin remodeling. Located in cytoplasm; nucleus; and polytene chromosome. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human ZNHIT1 (zinc finger HIT-type containing 1)." FBgn0053113 FlyBase Gene Snapshot "Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes." FBgn0051971 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be located in cytosol. FBgn0031693 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VMS9) FBgn0031694 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VMS8) FBgn0031695 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VMS7) FBgn0031696 FlyBase Gene Snapshot Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. FBgn0016076 FlyBase Gene Snapshot vrille (vri) encodes a bZIP transcription factor acting as an enhancer of dpp phenotypes both in embryo and in wing. It is involved in hair and cell growth and in tracheal development. Vri is a clock-controlled gene acting as a repressor of the products of Clk and cry. FBgn0015031 FlyBase Gene Snapshot cyclope (cype) encodes a cytochrome c oxidase subunit VIc homolog acting as an enhancer of dpp pathway phenotypes. It is involved in hair and cell growth and in ommatidia development. FBgn0031701 FlyBase Gene Snapshot Turandot M (TotM) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. FBgn0016920 FlyBase Gene Snapshot "no mechanoreceptor potential C (nompC) encodes a pore-forming subunit for a mechanosensitive non-selective cation channel. It belongs to the TRP channel family and is expressed in peripheral sensory neurons. It senses gentle touch and regulates locomotion in larval body wall neurons. In the adult, the product of nompC is involved in hearing transduction in the Johnston's organ." FBgn0016660 FlyBase Gene Snapshot H15 (H15) encodes a T-box transcription factor that regulates the specification of cell fate in the heart and central nervous system. FBgn0031703 Alliance Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in peroxisome. Is expressed in adult head. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). FBgn0031702 FlyBase Gene Snapshot fuseless (fusl) encodes a protein involved in the clustering of voltage-gated calcium channels and the exocytosis of calcium-dependent synaptic vesicles. FBgn0031700 Alliance Predicted to enable acylphosphatase activity. Is expressed in adult head. Orthologous to human ACYP2 (acylphosphatase 2). FBgn0031698 FlyBase Gene Snapshot "Nuclear receptor coactivator 6 (Ncoa6) encodes a subunit of the Trithorax-related (Trr) complex, a COMPASS-like complex that mediates the methylation of histone H3K4. The product of Ncoa6 is required for transcriptional output of the Hippo pathway by directly interacting with the protein encoded by yki and recruiting the Trr complex to Hippo target genes." FBgn0031697 Alliance Predicted to enable sulfotransferase activity. Predicted to be involved in carbohydrate biosynthetic process. Predicted to be located in membrane. Orthologous to human CHST9 (carbohydrate sulfotransferase 9). FBgn0000228 FlyBase Gene Snapshot "Ninein (Nin) encodes the ortholog of Ninein, a microtubule-anchoring protein in humans. Nin is highly expressed at blastoderm stage embryos and its product localizes to the centrosome periphery." FBgn0003716 FlyBase Gene Snapshot "thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway." FBgn0051914 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031707 Alliance Predicted to be involved in cilium assembly and regulation of protein localization. Predicted to be active in ciliary membrane and ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Orthologous to human TMEM231 (transmembrane protein 231). FBgn0000318 FlyBase Gene Snapshot clot (cl) encodes a protein with thioredoxin reductase and glutathione peroxidase enzymatic activity. cl is required for drosopterin biosynthesis and its product contributes to redox homeostasis and signaling and defence against oxidative stress. FBgn0031711 UniProtKB "Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:36302967). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:36302967). Binding by the elongator complex stabilizes microtubules and promotes their growth (PubMed:36302967). This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells (PubMed:36302967). (UniProtKB:Q9VMQ7)" FBgn0051989 Interactive Fly "condensin II subunit, chromosome assembly and segregation during mitosis and meiosis - regulation of anti-bacterial immune determinants - restriction of retrotransposon mobilization" FBgn0051648 Alliance Predicted to enable copper ion binding activity. Predicted to be involved in aerobic respiration and protein-containing complex assembly. Predicted to be located in mitochondrial envelope. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 23. Orthologous to human COX11 (cytochrome c oxidase copper chaperone COX11). FBgn0051915 Alliance Predicted to enable procollagen galactosyltransferase activity. Predicted to be involved in positive regulation of collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Is expressed in adult head. Human ortholog(s) of this gene implicated in brain small vessel disease 3. Orthologous to several human genes including COLGALT1 (collagen beta(1-O)galactosyltransferase 1) and COLGALT2 (collagen beta(1-O)galactosyltransferase 2). FBgn0002525 UniProtKB "Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:15035436, PubMed:3126192). May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308). In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967). Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811). In addition, is required for nuclear envelope localization of klar (PubMed:14617811). (UniProtKB:P08928)" FBgn0031717 FlyBase Gene Snapshot Glucosamine-6-phosphate deaminase (Gnpda) encodes a putative enzyme that is predicted to catalyze the reversible conversion of alpha-D-glucosamine 6-phosphate into beta-D-fructose 6-phosphate and an ammonium ion. It is involved in UDP-N-acetylglucosamine metabolism. FBgn0031721 Alliance Orthologous to human CFAP299 (cilia and flagella associated protein 299). FBgn0004620 FlyBase Gene Snapshot Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. FBgn0041719 Alliance "Predicted to enable U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U4 snRNP." FBgn0031724 Alliance Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human CCDC34 (coiled-coil domain containing 34). FBgn0031728 FlyBase Gene Snapshot "Heat shock protein 60C (Hsp60C) encodes one of the four Hsp60 family chaperone proteins. It is widely expressed and essential for embryonic viability and tracheal formation. It has essential roles in spermatogenesis and oogenesis, possibly through interaction with F-Actin." FBgn0031729 Alliance Predicted to be involved in autophagy of mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC1 (FUN14 domain containing 1) and FUNDC2 (FUN14 domain containing 2). FBgn0051646 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in optic lobe intrinsic neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). FBgn0031725 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in optic lobe intrinsic columnar neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NTM (neurotrimin); and OPCML (opioid binding protein/cell adhesion molecule like). FBgn0031723 Alliance Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human CCDC34 (coiled-coil domain containing 34). FBgn0031722 Alliance Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human CCDC34 (coiled-coil domain containing 34). FBgn0031720 Alliance Orthologous to human CFAP299 (cilia and flagella associated protein 299). FBgn0031718 Alliance Is expressed in organism; yolk; and yolk nucleus. FBgn0014189 FlyBase Gene Snapshot "Helicase at 25E (Hel25E) encodes the UAP56 RNA helicase in the DECD subfamily of DEAD-box helicases. It is an enhancer of position-effect variegation, and contributes to mRNA splicing, nuclear export, and piRNA biosynthesis. The product of Hel25E binds heterochromatic cluster transcripts, along with the product of vas, to organize a piRNA-processing compartment that spans the nuclear envelope to silence transposon transcripts." FBgn0031716 Alliance "Predicted to enable glycoprotein endo-alpha-1,2-mannosidase activity. Predicted to be active in Golgi membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in anxiety disorder; cocaine dependence; and panic disorder. Orthologous to human MANEA (mannosidase endo-alpha) and MANEAL (mannosidase endo-alpha like)." FBgn0031715 FlyBase Gene Snapshot tombola (tomb) encodes a tesmin/TSO1-family protein involved in the transcriptional activation of the male germline. FBgn0031713 UniProtKB "FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (UniProtKB:Q9VMQ5)" FBgn0031710 Alliance Enables small GTPase binding activity. Involved in endocytic recycling. Located in trans-Golgi network. Part of GARP complex. Is expressed in organism. Orthologous to human VPS52 (VPS52 subunit of GARP complex). FBgn0031708 Alliance Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in adult head; adult heart; and organism. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21). FBgn0031730 Alliance Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human CDKL1 (cyclin dependent kinase like 1) and CDKL4 (cyclin dependent kinase like 4). FBgn0024191 UniProtKB May be involved in pre-mRNA splicing. (UniProtKB:Q9Y103) FBgn0031736 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus and nucleoplasm. Is expressed in adult brain cell body rind. Orthologous to human NGDN (neuroguidin)." FBgn0031735 Alliance Predicted to enable calcium-independent phospholipase A2 activity and lysophospholipase activity. Predicted to be involved in phospholipid metabolic process. Orthologous to human PLB1 (phospholipase B1). FBgn0051913 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrial inner membrane. Orthologous to human COA1 (cytochrome c oxidase assembly factor 1). FBgn0031740 Alliance Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. Is expressed in organism and spermatozoon. FBgn0031741 Alliance Enables dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; asthma; autosomal dominant intellectual developmental disorder 33; motor neuron disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including DPP4 (dipeptidyl peptidase 4); DPP10 (dipeptidyl peptidase like 10); and DPP6 (dipeptidyl peptidase like 6). FBgn0031746 FlyBase Gene Snapshot CG9029 encodes a peptide that is produced by the male accessory gland and transferred to females during mating. FBgn0043362 FlyBase Gene Snapshot "blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism." FBgn0015381 FlyBase Gene Snapshot "dissatisfaction (dsf) encodes a nuclear receptor that regulates hemocyte proliferation, courtship behavior and neural differentiation." FBgn0001128 FlyBase Gene Snapshot "Glycerol-3-phosphate dehydrogenase 1 (Gpdh1) encodes a glycerol-3-phosphate dehydrogenase that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate. It is involved in triglyceride metabolism, response to hyperoxia and flight behavior." FBgn0031752 Alliance Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human STK11IP (serine/threonine kinase 11 interacting protein). FBgn0031753 Alliance Predicted to be involved in cilium assembly. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 16. Orthologous to human TMEM138 (transmembrane protein 138). FBgn0002855 FlyBase Gene Snapshot Accessory gland protein 26Aa (Acp26Aa) encodes a protein synthesized in male accessory glands. It is transferred during mating to females where it induces an increase in ovulation by relaxing the oviduct via activation of octopaminergic signaling. FBgn0002856 FlyBase Gene Snapshot Accessory gland protein 26Ab (Acp26Ab) encodes a peptide that is produced by male accessory glands and transferred to females during mating. FBgn0031745 FlyBase Gene Snapshot rau (rau) encodes a protein that sustains RTK signaling downstream of the product of htl or Egfr. This effect is mediated by the two Ras association (RA) domains that together show a binding preference for GTP-loaded Ras. rau depletion produces a rough eye phenotype and reduced differentiation of retinal wrapping glia. FBgn0051644 Alliance Is expressed in adult head and spermatozoon. FBgn0031739 Alliance Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. Is expressed in organism. FBgn0031738 Alliance "Predicted to enable glucuronosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval plasmatocyte; embryonic/larval posterior spiracle; eye; and plasmatocyte primordium." FBgn0031737 UniProtKB Chitin-binding protein that is important for the longitudinal contraction and lateral expansion of the larval cuticle during its conversion into the oval-shaped puparium case. Essential for survival to the second instar larval stage. Confers the orientated contractility and expandability of the larval cuticle by regulating the arrangement of chitin and the formation of supracellular ridges on the cuticle of third instar larvae. Essential for determining pupal body shape; required for the orientated shape change of the cuticle during metamorphosis which involves changes in the morphology of the supracellular ridges. (UniProtKB:Q9VMM6) FBgn0031734 Alliance "Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Predicted to be located in membrane. Is expressed in several structures, including adult fat body; adult head; embryonic dorsal epidermis; embryonic head epidermis; and gut section." FBgn0031733 Alliance Predicted to be active in nuclear envelope. FBgn0031732 Alliance Predicted to enable glucuronosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in Golgi apparatus. Is expressed in adult head. FBgn0003980 UniProtKB Major early eggshell protein. (UniProtKB:P13238) FBgn0031757 FlyBase Gene Snapshot Ucp4C (Ucp4C) may encode an uncoupling protein (UCP) that mediates uncoupled respiration and energy dissipation based on sequence homology. FBgn0031758 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in response to cold. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). FBgn0001942 FlyBase Gene Snapshot eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. FBgn0001941 UniProtKB "Has sphingolipid-delta-4-desaturase activity. Converts sphinganine-containing sphingolipids (such as N-acylsphinganines or dihydroceramides) into sphingolipids containing the delta-4-desaturated sphingoid base (E)-sphing-4-enine (such as N-acylsphing-4-enines or ceramides), which are required for many different functions (structural functions as well as signaling) (PubMed:11937514). Required to initiate spermatid differentiation among other signals (PubMed:9003299). Required for central spindle assembly and cytokinesis during male meiosis, may act as part of an anchoring mechanism that links membrane-bounded cellular compartments to components of the cytoskeleton (PubMed:9819060). (UniProtKB:Q94515)" FBgn0031760 FlyBase Gene Snapshot "Tetraspanin 26A (Tsp26A) encodes a member of the tetraspanin superfamily. With two other tetraspanins, encoded by Tsp3A and Tsp86D, it regulates the trafficking of the product of kuz and consequently Notch signaling and several Notch-dependent developmental processes." FBgn0031763 Alliance Orthologous to human SAMD15 (sterile alpha motif domain containing 15). FBgn0051643 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; and trunk mesoderm. Orthologous to human FASTKD1 (FAST kinase domains 1)." FBgn0031768 Alliance Predicted to enable protein homodimerization activity. Involved in endosome organization. Located in endosome. Orthologous to several human genes including PHETA1 (PH domain containing endocytic trafficking adaptor 1). FBgn0031769 Alliance "Predicted to enable small GTPase binding activity. Predicted to be active in membrane. Is expressed in several structures, including antennal primordium; anterior endoderm anlage; ganglia; head epidermis primordium; and sensory nervous system primordium. Orthologous to human RCC2 (regulator of chromosome condensation 2)." FBgn0031770 Alliance Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0031772 Alliance Predicted to enable protein phosphatase 1 binding activity; protein serine/threonine phosphatase inhibitor activity; and ubiquitin protein ligase activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in nucleus. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). FBgn0031774 Alliance Predicted to enable acyltransferase activity. Orthologous to human C5orf63 (chromosome 5 open reading frame 63). FBgn0031776 Alliance "Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; embryonic/larval nervous system; and ganglia. Orthologous to human PFDN1 (prefoldin subunit 1)." FBgn0051642 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in synaptic signaling. Predicted to be active in plasma membrane. FBgn0031784 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Is expressed in adult head. Orthologous to human TSSK4 (testis specific serine kinase 4). FBgn0031785 Alliance Is expressed in spermatozoon. FBgn0040950 Alliance "Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval salivary gland; embryonic/larval tracheal section; and proventriculus." FBgn0031782 FlyBase Gene Snapshot WD repeat domain 79 (WDR79) encodes a protein that binds to the CAB box of the Small Cajal body-specific RNAs (scaRNAs). It is a component of the nuclear Cajal body (CB) and is required for CB formation. FBgn0031779 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and regulation of COPII vesicle coating. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; gland; gut section; hindgut proper primordium; and larval ventral nerve cord. Orthologous to human PREB (prolactin regulatory element binding)." FBgn0031777 UniProtKB S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha. (UniProtKB:Q9VMH7) FBgn0031775 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult head and eye. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0031773 FlyBase Gene Snapshot "F-box and WD repeat domain containing 5 (Fbw5) encodes a protein that targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of the product of Fbw5 is the subunit of the tuberous sclerosis complex encoded by gig, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway." FBgn0031771 FlyBase Gene Snapshot "NADH dehydrogenase (ubiquinone) 51 kDa subunit (ND-51) encodes a flavoprotein and iron-sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. It is a component of the mitochondrial electron transport complex I, which is part of the oxidative phosphorylation pathway. It may have a role in regulating aggression behavior." FBgn0029161 UniProtKB Required to regulate peristaltic movement and also for germline proliferation in males and females. (UniProtKB:Q9V3U9) FBgn0000052 FlyBase Gene Snapshot "Phosphoribosylformylglycinamidine synthase (Pfas) encodes a phosphoribosylformylglycinamidine synthase, which is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes." FBgn0031766 Alliance Predicted to enable RNA endonuclease activity. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). FBgn0025742 FlyBase Gene Snapshot "myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling." FBgn0031764 Alliance Predicted to enable nucleic acid binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to be part of CURI complex and UTP-C complex. Is expressed in organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A). FBgn0001170 FlyBase Gene Snapshot Homeodomain protein 2.0 (H2.0) encodes a homeodomain transcription factor that is expressed in the embryonic visceral mesoderm. FBgn0001089 FlyBase Gene Snapshot "beta galactosidase (Gal) encodes a putative digestive enzyme that hydrolyses beta-galactosides into monosaccharides. Gal is highly expressed and enriched in the midgut, an organ involved in digestion." FBgn0031759 FlyBase Gene Snapshot "Lysine demethylase 5 (Kdm5) encodes a trimethyl H3K4 histone demethylase that regulates transcription through both demethylase-dependent and demethylase-independent mechanisms. It has roles in regulating cell growth, circadian rhythm, stress resistance, hematopoiesis and fertility." FBgn0000308 FlyBase Gene Snapshot "chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance." FBgn0003979 UniProtKB Major early eggshell protein. (UniProtKB:P11449) FBgn0040949 Alliance Involved in vitelline membrane formation involved in chorion-containing eggshell formation. FBgn0026755 Alliance Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is expressed in adult head. Orthologous to human UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). FBgn0031791 UniProtKB "Catalyzes the formation of long-chain N-acylserotonins and N-acyldopamines, which are important cellular signaling lipids (PubMed:24444601, PubMed:31385627). Catalyzes in vitro the formation of various N-acetyl-2-arylethylamines such as N-acetyltryptamine and melatonin (PubMed:11098219, PubMed:26476413). (UniProtKB:Q9VMG0)" FBgn0015623 UniProtKB This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. (UniProtKB:Q27597) FBgn0031803 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval tracheal dorsal trunk; tracheal node; and tracheal tip cell. FBgn0031805 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in dorsal ectoderm anlage and ventral ectoderm anlage. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0043854 FlyBase Gene Snapshot "slow as molasses (slam) encodes a protein involved in cortical polarization and furrow invagination during cellularization, as well in germ cell migration during later embryogenesis. slam RNA co-localizes and forms a complex with its encoded protein, which is needed for full expression and subcellular localization." FBgn0031808 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0031815 FlyBase Gene Snapshot farjavit (frj) encodes a lysophospholipid acyltransferase that preferentially adds arachidonic acid to lysophosphatidylinositol. FBgn0031820 UniProtKB "Transcription regulator (PubMed:17933869, PubMed:23593018). Acts as a histone chaperone that facilitates deposition of histone H3.3 (PubMed:28320872). Has a role in chromatin remodeling together with asf1 and XNP (PubMed:28320872). Has role in the transcriptional apoptotic response to oxidative and UV stress (PubMed:17933869, PubMed:23593018). (UniProtKB:Q9VMD0)" FBgn0027496 Alliance Predicted to enable structural molecule activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human COPE (COPI coat complex subunit epsilon). FBgn0051638 FlyBase Gene Snapshot CG31638 is expressed in the mesoderm and is regulated by the RNA-binding protein encoded by how. FBgn0031824 Alliance Predicted to enable fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and fatty-acyl-CoA biosynthetic process. Predicted to be located in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). FBgn0031822 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human PHF5A (PHD finger protein 5A)." FBgn0031818 Alliance "Predicted to be involved in protein glycosylation and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in adult head and organism. Orthologous to human TMEM115 (transmembrane protein 115)." FBgn0031817 Alliance Predicted to enable protein-(glutamine-N5) methyltransferase activity. Orthologous to human HEMK1 (HemK methyltransferase family member 1). FBgn0031816 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of gliogenesis. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in embryonic large intestine and yolk nucleus. Orthologous to human RCHY1 (ring finger and CHY zinc finger domain containing 1). FBgn0031814 Alliance Located in mitochondrion. Is expressed in adult head. Orthologous to several human genes including SEC14L5 (SEC14 like lipid binding 5). FBgn0011722 FlyBase Gene Snapshot Tiggrin (Tig) is an extracellular matrix protein and integrin ligand that accumulates at the embryonic and larval muscle attachment site. It is also found as a component of the hemolymph clot. FBgn0031804 Alliance Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to several human genes including MFAP4 (microfibril associated protein 4). FBgn0031801 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0031800 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0031799 FlyBase Gene Snapshot Pez (Pez) encodes an adaptor protein that is degraded via the product of Su(dx). It contributes to stem cell proliferation by regulating Hippo signalling. It interacts with the product of kibra and restricts the product of yki activity. FBgn0031792 Alliance Is expressed in embryonic/larval posterior spiracle; organism; and posterior spiracle primordium. FBgn0031826 Alliance Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and sulfur compound metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in macular corneal dystrophy; osteochondrodysplasia; and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to several human genes including CHST3 (carbohydrate sulfotransferase 3) and CHST5 (carbohydrate sulfotransferase 5). FBgn0051637 Alliance Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and sulfur compound metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in macular corneal dystrophy. Orthologous to several human genes including CHST4 (carbohydrate sulfotransferase 4). FBgn0031830 Alliance "Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; ganglia; gut section; and mesoderm. Used to study cytochrome-c oxidase deficiency disease. Orthologous to human COX5B (cytochrome c oxidase subunit 5B)." FBgn0031831 Alliance "Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial envelope. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and spermatozoon. Orthologous to human COX5B (cytochrome c oxidase subunit 5B)." FBgn0031836 Alliance Predicted to enable 5'-deoxynucleotidase activity. Orthologous to human HDDC2 (HD domain containing 2). FBgn0028467 Alliance "Predicted to enable ubiquitin-ubiquitin ligase activity. Involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic esophagus; embryonic hypopharynx; embryonic/larval visceral muscle cell; and visceral mesoderm derivative. Orthologous to human UBE4A (ubiquitination factor E4A)." FBgn0000392 UniProtKB "Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos (PubMed:9118812). Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation (PubMed:21937713). Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G (PubMed:14685270, PubMed:15465908, PubMed:21081899). This may contribute to translational repression but does not appear to be necessary for it to occur (PubMed:21081899). Can promote translational repression independently of deadenylation and eIF4E1 binding (PubMed:21937713). Required for correct localization of eIF4E1 in the developing oocyte (PubMed:15465908). Required for translational repression of oskar (osk) mRNA (PubMed:14691132, PubMed:14723848). Also required for the translational repression of nanos (nos) mRNA (PubMed:21081899). Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development (PubMed:17277377, PubMed:22454519). Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte (PubMed:22164257). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934). (UniProtKB:Q9VMA3)" FBgn0031851 FlyBase Gene Snapshot "Apoptosis antagonizing transcription factor (Aatf) encodes a transcription factor that is a target of the kinases encoded by tefu and lok. It is involved in the control of the cell cycle, DNA damage response, and regulation of apoptosis." FBgn0046704 FlyBase Gene Snapshot Liprin-alpha (Liprin-alpha) encodes a scaffolding protein that interacts with the receptor phosphatase Lar. It is involved in synapse morphogenesis and axon guidance. FBgn0031853 UniProtKB "Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis. (UniProtKB:Q9VM92)" FBgn0031855 UniProtKB "Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM). (UniProtKB:Q9VM90)" FBgn0031854 UniProtKB "Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains. (UniProtKB:Q9VM91)" FBgn0025777 FlyBase Gene Snapshot "homer (homer) encodes a protein that acts as an adaptor protein binding to group I metabotropic glutamate receptors and other intracellular signaling proteins. It contributes to regulation of sleep, locomotor activity and ethanol tolerance." FBgn0025595 FlyBase Gene Snapshot Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. FBgn0031850 FlyBase Gene Snapshot Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons. FBgn0031849 Alliance Is expressed in adult head. FBgn0028703 Alliance Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Located in perinuclear region of cytoplasm. Is expressed in adult central nervous system; adult head; and organism. Human ortholog(s) of this gene implicated in Christianson syndrome; X-linked intellectual developmental disorder 108; and autistic disorder. Orthologous to several human genes including SLC9A9 (solute carrier family 9 member A9). FBgn0031848 FlyBase Gene Snapshot "Non-SMC element 1 (Nse1) encodes a RING finger protein with E3 ubiquitin ligase activity that is part of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes." FBgn0000351 FlyBase Gene Snapshot "cortex (cort) encodes a member of the Cdc20 family of activators of the Anaphase Promoting Complex (APC). It activates the APC specifically in the oocyte to release the metaphase I arrest, permitting completion of meiosis and several egg activation events." FBgn0028990 FlyBase Gene Snapshot Serpin 27A (Spn27A) encodes a hemolymphatic serpin that negatively regulates a serine protease involved in the melanization cascade. It also inhibits the serine protease encoded by ea in dorsoventral patterning of the early embryo. FBgn0031844 Alliance Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Predicted to be active in mitochondrion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). FBgn0051636 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Orthologous to human TTPAL (alpha tocopherol transfer protein like). FBgn0051633 Alliance Predicted to enable SCF ubiquitin ligase complex binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0051635 Alliance Orthologous to human PPP1R37 (protein phosphatase 1 regulatory subunit 37). FBgn0051634 Alliance "Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including embryonic/larval nervous system; ganglia; mesectoderm; midline primordium; and ventral midline of embryo. Orthologous to human SLCO4A1 (solute carrier organic anion transporter family member 4A1)." FBgn0031837 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NTM (neurotrimin); and OPCML (opioid binding protein/cell adhesion molecule like). FBgn0031834 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0031832 Alliance "Predicted to be involved in tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; foregut primordium; and hindgut proper primordium. Used to study candidiasis. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)." FBgn0031829 Alliance Predicted to be involved in cilium assembly and intraciliary transport. Predicted to be part of intraciliary transport particle B. Predicted to be active in centriole and cilium. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human IFT52 (intraflagellar transport 52). FBgn0031858 Alliance Orthologous to human KIAA0513 (KIAA0513). FBgn0051631 Alliance Predicted to enable AGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031860 Alliance Predicted to enable D-amino-acid oxidase activity. Predicted to be involved in D-amino acid catabolic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase) and DDO (D-aspartate oxidase). FBgn0051632 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and posterior midgut primordium. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gray platelet syndrome; myelodysplastic syndrome; platelet-type bleeding disorder 17; and severe congenital neutropenia 2. Orthologous to several human genes including GFI1B (growth factor independent 1B transcriptional repressor)." FBgn0017551 FlyBase Gene Snapshot Regulator of cyclin A1 (Rca1) encodes an anaphase-promoting complex/cyclosome inhibitor. It contributes to mitotic G1/S transition and cyclin degradation. FBgn0031866 FlyBase Gene Snapshot "Neuroligin 2 (Nlg2) encodes a transmembrane protein that interacts with the product of Nrx-1, and recruits scaffolding proteins for organization of postsynaptic neurotransmitter receptors. The product of Nlg2 functions in synaptic growth and regulation, and is involved in the modulation of social and courtship behavior." FBgn0031868 FlyBase Gene Snapshot "Rat1 5'-3' exoribonuclease (Rat1) encodes a member of the 5'-3' exonuclease family. It is required for mRNA processing and mutations cause phenotypes in various cell types, including the nervous system." FBgn0004838 UniProtKB This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. Interacts with grk mRNA (via 3' UTR) and involved in its localization to the dorsal anterior region of the oocyte during dorsal-ventral axis determination; may function as a ribonuclear protein complex together with sqd and otu (PubMed:15056611). Required for polytene chromosome dispersal in nurse cells during oogenesis (PubMed:15056611). May be involved in the regulation of splicing (PubMed:9372958). (UniProtKB:P48809) FBgn0020616 FlyBase Gene Snapshot "Stromalin 1 (SA1) encodes a subunit of the cohesin ring complex, which encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair." FBgn0031875 UniProtKB Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin (By similarity). (UniProtKB:Q9VM60) FBgn0031877 Alliance Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Predicted to be located in cytosol; endoplasmic reticulum; and peroxisome. Is expressed in adult head. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). FBgn0021944 UniProtKB Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity). (UniProtKB:Q9V3D2) FBgn0031879 FlyBase Gene Snapshot uninflatable (uif) encodes a single pass transmembrane protein that localizes to the apical plasma membrane in epithelial cells. It is required for embryonic tracheal maturation and tracheal growth in the larva. FBgn0016978 FlyBase Gene Snapshot small ribonucleoprotein particle U1 subunit 70K (snRNP-U1-70K) encodes a protein component of the U1 snRNP. The U1 snRNP combines with other snRNPs on the pre-mRNA to assemble a spliceosome. FBgn0031878 Alliance "Involved in mitotic cytokinesis and protein localization. Colocalizes with microtubule plus-end; midbody; and mitotic spindle midzone. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; ganglia; and head epidermis primordium." FBgn0031876 FlyBase Gene Snapshot Ada2a-containing complex component 1 (Atac1) encodes a protein involved in chromatin remodeling and histone acetylation. FBgn0031874 Alliance Predicted to enable DNA binding activity and protein dimerization activity. Is expressed in organism. Orthologous to several human genes including ZBED4 (zinc finger BED-type containing 4). FBgn0031873 FlyBase Gene Snapshot Gas41 (Gas41) encodes a protein that contributes to histone acetylation and is involved in chromatin organization and RNA interference. FBgn0031872 FlyBase Gene Snapshot "interference hedgehog (ihog) encodes a type 1 membrane protein that acts as a co-receptor for the product of hh upstream or at the level of the receptor encoded by ptc. It interacts with the products of disp, dlp, dally and shf. It is involved in imaginal pattern formation and embryonic cuticle pattern formation." FBgn0031871 Alliance Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. Is expressed in adult head and organism. Orthologous to several human genes including FGFR1OP2 (FGFR1 oncogene partner 2). FBgn0031869 Alliance Is expressed in adult head and spermatozoon. Orthologous to human MTCL3 (MTCL family member 3); MTCL1 (microtubule crosslinking factor 1); and MTCL2 (microtubule crosslinking factor 2). FBgn0028554 FlyBase Gene Snapshot x16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. FBgn0026196 Alliance "Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus. Is expressed in several structures, including gut section; head epidermis primordium; imaginal disc; mesoderm; and visceral mesoderm derivative. Orthologous to human NOP58 (NOP58 ribonucleoprotein)." FBgn0011737 FlyBase Gene Snapshot Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes. FBgn0042092 Alliance Predicted to be involved in transcription elongation by RNA polymerase I. Predicted to be part of RNA polymerase I complex. Orthologous to human POLR1F (RNA polymerase I subunit F). FBgn0031865 FlyBase Gene Snapshot Na[+]/H[+] hydrogen antiporter 1 (Nha1) encodes a chloride transmembrane transporter belonging to the CPA2 family of cation/proton antiporter family. FBgn0031861 Alliance Predicted to enable N-acetyltransferase activity. FBgn0015776 FlyBase Gene Snapshot "nervana 1 (nrv1) encodes a beta subunit of the Na[+], K[+] ATPase ion pump, which is important for maintaining cellular membrane potential in muscles." FBgn0031857 FlyBase Gene Snapshot "Linear Ubiquitin E3 ligase (LUBEL) encodes an E3 ligase belonging to the RBR (RING-in-between-RING)-type ubiquitin E3 ligase family. It specifically generates N-terminal methionine-linked ubiquitin chains, which are important for heat-tolerance in vivo." FBgn0031856 Alliance Predicted to be active in nucleus. FBgn0003046 UniProtKB Component of the cuticle of the pupa of fruit fly. (UniProtKB:P14484) FBgn0031881 UniProtKB "Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis. (UniProtKB:Q9VM51)" FBgn0031885 FlyBase Gene Snapshot "Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like." FBgn0031887 Alliance Predicted to enable UDP-glycosyltransferase activity. Orthologous to several human genes including UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus); UGT2A2 (UDP glucuronosyltransferase family 2 member A2); and UGT2A3 (UDP glucuronosyltransferase family 2 member A3). FBgn0031893 UniProtKB "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:27568554). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 induces a conformational change that weakens MCU-MICU1 interactions and moves MICU1 away from the pore, allowing calcium permeation through the MCU channel (By similarity). Also required to protect against manganese toxicity by preventing manganese uptake by MCU (By similarity). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult (PubMed:27568554). (UniProtKB:A2VEI2)" FBgn0051909 Alliance "Is expressed in several structures, including endoderm anlage; foregut anlage in statu nascendi; head mesoderm anlage; mesoderm anlage; and posterior ectoderm anlage." FBgn0031897 Alliance "Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport; phospholipid translocation; and retrograde transport, endosome to Golgi. Predicted to be located in lysosomal membrane. Predicted to be active in endosome and trans-Golgi network. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; dorsal ectoderm anlage; and mesoderm. Orthologous to human SLC66A2 (solute carrier family 66 member 2)." FBgn0031896 UniProtKB Catalyzes the covalent attachment of ubiquitin to other proteins. (UniProtKB:Q9VM35) FBgn0031895 Alliance Predicted to enable protein serine/threonine phosphatase inhibitor activity. Is expressed in head visceral muscle primordium; organism; and visceral muscle primordium. Orthologous to several human genes including PABIR2 (PABIR family member 2) and PABIR1 (PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1). FBgn0031894 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism and spermatozoon." FBgn0031888 FlyBase Gene Snapshot "PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells." FBgn0031886 FlyBase Gene Snapshot Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. FBgn0051907 FlyBase Gene Snapshot Male specific transcript 27D (Mst27D) encodes a protein required for normal elongation of the spermatid nucleus from spherical to needle shape. Mst27D is transcribed exclusively in mid to late spermatocytes. FBgn0031882 FlyBase Gene Snapshot "Rab30 (Rab30) encodes a JNK transcriptional target. It is involved in JNK-mediated processes such as dorsal closure, embryonic head involution and thorax closure." FBgn0051908 Alliance Is expressed in organism. Orthologous to human SZRD1 (SUZ RNA binding domain containing 1). FBgn0031902 FlyBase Gene Snapshot Wnt oncogene analog 6 (Wnt6) encodes a member of the Wnt family that can activate canonical Wnt signaling. It is expressed in the dorsal/ventral boundary of the wing and the maxillary palp. It contributes to maxillary palp formation. FBgn0031903 FlyBase Gene Snapshot Wnt oncogene analog 10 (Wnt10) encodes a member of the Wnt protein family with unknown function. FBgn0002938 UniProtKB Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities (PubMed:2449973). Essential for the expression and stability of the rtp protein in the photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554). (UniProtKB:P10676) FBgn0031905 UniProtKB Important for spermatogenesis where it may have a role in sperm individualization. (UniProtKB:Q9VM21) FBgn0031907 Alliance Enables trehalose-phosphatase activity. Predicted to be involved in trehalose biosynthetic process. Is expressed in adult head; adult midgut progenitor cell; amnioserosa; embryonic/larval midgut; and yolk nucleus. FBgn0031908 Alliance Predicted to be involved in trehalose biosynthetic process. Located in extracellular region. Is expressed in adult head; adult heart; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. FBgn0031910 Alliance Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Is expressed in embryonic proventriculus and embryonic/larval midgut. Human ortholog(s) of this gene implicated in 3MC syndrome 3; asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to several human genes including COLEC10 (collectin subfamily member 10); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). FBgn0028387 FlyBase Gene Snapshot chameau (chm) encodes a histone acetyl transferase involved in epigenetic mechanisms of transcriptional control and regulation of replication origin activity. Its functions include modulation of JNK activity and gene regulation by Polycomb group genes. FBgn0031914 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Is expressed in adult head; amnioserosa; embryonic/larval midgut; and yolk nucleus. Orthologous to human TTPAL (alpha tocopherol transfer protein like). FBgn0031918 Alliance "Predicted to enable carbohydrate binding activity. Is expressed in several structures, including adult head; dorsal sensory complex proper primordium; epithelium; gland; and gut section." FBgn0011283 Alliance "Predicted to enable pheromone binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in several structures, including antennal primordium; antennal sense organ; basiconic sensillum; eo sensory organ accessory cell; and organism subdivision." FBgn0045495 FlyBase Gene Snapshot Gustatory receptor 28b (Gr28b) encodes a gustatory receptor involved in the detection of some bitter taste compounds. It is necessary for the detection of L-canavanine and coumarin. FBgn0041247 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands. (UniProtKB:Q9VM09)" FBgn0025697 FlyBase Gene Snapshot scavenger receptor acting in neural tissue and majority of rhodopsin is absent (santa-maria) encodes a class B scavenger receptor that contributes to the conversion of carotenoids to vitamin A. It is involved in phototransduction and thermotaxis. FBgn0031913 Alliance "Predicted to enable phosphatidylinositol bisphosphate binding activity and retinal binding activity. Predicted to be involved in response to light stimulus. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval hemocyte; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to several human genes including TTPAL (alpha tocopherol transfer protein like)." FBgn0031909 Alliance Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination and response to ionizing radiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SOSS complex. Orthologous to several human genes including NABP1 (nucleic acid binding protein 1). FBgn0031906 Alliance "Predicted to enable GTP binding activity and GTPase activity. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic brain; embryonic central brain; and head epidermis primordium." FBgn0031904 Alliance "Is expressed in several structures, including adult head; amnioserosa; embryonic central brain neurons; embryonic/larval glial cell; and ganglia. Orthologous to human MEAK7 (MTOR associated protein, eak-7 homolog)." FBgn0083141 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB12 (serpin family B member 12); and SERPINB13 (serpin family B member 13). FBgn0031925 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VLZ7) FBgn0031926 Alliance "Predicted to be active in plasma membrane. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic dorsal epidermis; embryonic epipharynx; and embryonic head epidermis." FBgn0040299 FlyBase Gene Snapshot Myosin 28B1 (Myo28B1) encodes a high duty ratio motor protein belonging to the MyTH4-FERM subgroup of actin-based molecular motors. FBgn0041181 FlyBase Gene Snapshot Thioester-containing protein 3 (Tep3) encodes a protein involved in the defense response to Gram-positive bacteria. FBgn0031941 Alliance "Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in adult head and spermatozoon. Orthologous to human ATP5MG (ATP synthase membrane subunit g) and ATP5MGL (ATP synthase membrane subunit g like)." FBgn0003961 UniProtKB "Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (UniProtKB:P16163)" FBgn0031947 Alliance "Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of brahma complex. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including BRD7 (bromodomain containing 7)." FBgn0031951 FlyBase Gene Snapshot "r2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC." FBgn0031952 Alliance "Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in cilium assembly; microtubule cytoskeleton organization; and regulation of cell cycle process. Predicted to be located in nucleus. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleolus. Is expressed in several structures, including anterior endoderm; anterior midgut primordium; embryonic/larval midgut; larval ventral nerve cord; and posterior endoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to several human genes including CDC14A (cell division cycle 14A)." FBgn0031950 Alliance "Involved in endoplasmic reticulum unfolded protein response. Is expressed in several structures, including adult head; embryonic/larval central nervous system; gland; gut section; and visceral mesoderm derivative. Orthologous to human HERPUD2 (HERPUD family member 2) and HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)." FBgn0031948 Alliance "Predicted to enable ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval midgut; embryonic/larval salivary gland; and fat body. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to human SELENOI (selenoprotein I)." FBgn0031940 Alliance Is expressed in adult head. FBgn0014454 UniProtKB Component of the cuticle of the adult fruit fly. Could be involved in thickening of the hard adult cuticle. (UniProtKB:Q26416) FBgn0031939 Alliance Predicted to enable glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to several human genes including SLC6A11 (solute carrier family 6 member 11); SLC6A12 (solute carrier family 6 member 12); and SLC6A13 (solute carrier family 6 member 13). FBgn0031937 Alliance "Predicted to enable glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; extraembryonic structure; and yolk nucleus. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to several human genes including SLC6A11 (solute carrier family 6 member 11); SLC6A12 (solute carrier family 6 member 12); and SLC6A13 (solute carrier family 6 member 13)." FBgn0031936 Alliance Predicted to enable glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; adult thorax; and organism. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to several human genes including SLC6A11 (solute carrier family 6 member 11); SLC6A12 (solute carrier family 6 member 12); and SLC6A13 (solute carrier family 6 member 13). FBgn0031935 Alliance Predicted to enable glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; adult thorax; and spermatozoon. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to several human genes including SLC6A11 (solute carrier family 6 member 11); SLC6A12 (solute carrier family 6 member 12); and SLC6A13 (solute carrier family 6 member 13). FBgn0053296 Alliance Predicted to enable glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to several human genes including SLC6A11 (solute carrier family 6 member 11); SLC6A12 (solute carrier family 6 member 12); and SLC6A13 (solute carrier family 6 member 13). FBgn0041182 FlyBase Gene Snapshot Thioester-containing protein 2 (Tep2) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep2 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. FBgn0031929 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA5 (carboxypeptidase A5). FBgn0027515 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic/larval muscle system; germline cell; and pole plasm. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)." FBgn0004177 FlyBase Gene Snapshot "microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling." FBgn0011861 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0031968 Alliance Predicted to be active in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including FAM151B (family with sequence similarity 151 member B). FBgn0031975 FlyBase Gene Snapshot "Transglutaminase (Tg) encodes an enzyme that catalyzes the isopeptide bond formation of epsilon-(gamma-glutamyl)lysine bonds in a Ca[2+]-dependent manner. It maintains the homeostasis of gut microbiota and promotes peritrophic matrix formation, as well as mediating cuticular morphogenesis and haemolymph coagulation." FBgn0031977 UniProtKB "Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle. (UniProtKB:Q9VLU0)" FBgn0044323 Alliance "Enables protein kinase binding activity. Involved in several processes, including morphogenesis of an epithelium; positive regulation of neuroblast proliferation; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. Part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including adult head and imaginal disc. Orthologous to several human genes including STRN3 (striatin 3)." FBgn0031979 UniProtKB "Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458). (UniProtKB:Q9VLT8)" FBgn0031981 Alliance Predicted to enable calcium ion binding activity. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human MEGF8 (multiple EGF like domains 8). FBgn0010287 FlyBase Gene Snapshot TBP-related factor (Trf) is ubiquitiously expressed but upregulated in the central nervous system and the gonads of developing Drosophila. The majority of the product of Trf substitutes for the product of Tbp in Pol III transcription in complex with the product of Brf. The rest of the product of Trf initiates transcription of a small subset of PolII-transcribed genes regulating fly fertility and nervous system function. FBgn0013531 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene. (UniProtKB:P91641)" FBgn0011230 FlyBase Gene Snapshot "purity of essence (poe) encodes a Calmodulin-binding, E3 ubiquitin ligase. It functions in glial growth in peripheral nerves, motor neuron excitability, synaptic vesicle release and sperm individuation." FBgn0031980 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head. Orthologous to human RPL36A (ribosomal protein L36a) and RPL36AL (ribosomal protein L36a like). FBgn0031976 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0031974 Alliance Predicted to enable glycine N-acyltransferase activity. Orthologous to several human genes including GLYATL3 (glycine-N-acyltransferase like 3). FBgn0031973 FlyBase Gene Snapshot Serpin 28Dc (Spn28Dc) encodes a hemolymphatic Serpin that negatively regulates an uncharacterized serine protease in the melanization cascade. FBgn0031972 FlyBase Gene Snapshot "WW domain containing oxidoreductase (Wwox) encodes a protein that contributes to homeostasis by regulating the balance between oxidative phosphorylation and glycolysis. It modulates the cell death mediated by the product of egr, which is accompanied by an increase in levels of reactive oxygen species." FBgn0031970 Alliance "Predicted to enable scavenger receptor activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval midgut primordium; embryonic/larval salivary gland; gut section; and visceral mesoderm derivative." FBgn0031969 UniProtKB (Microbial infection) Plays a role in mycobacterial infection. Mediates infection by M.fortuitum and uptake of M.smegmatis. (UniProtKB:B7Z031) FBgn0053121 Alliance Involved in sexual reproduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). FBgn0051902 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91; intermediate coronary syndrome; thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB12 (serpin family B member 12); and SERPINB13 (serpin family B member 13). FBgn0031961 Alliance Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human BTBD19 (BTB domain containing 19). FBgn0031959 UniProtKB Neurotrophin which may function as a ligand to the Toll-related receptor Tollo. Involved in a Tollo and JNK signaling pathway that positively regulates neuromuscular junction (NMJ) growth in presynaptic motorneurons. May function by activating Tollo to promote the phosphorylation of JNK. (UniProtKB:Q9VLV7) FBgn0045038 FlyBase Gene Snapshot Proctolin (Proc) encodes a neuropeptide precursor protein that binds the product of Proc-R and is involved in heart rate regulation. FBgn0031957 FlyBase Gene Snapshot "TweedleE (TwdlE) is one of 27 related insect-specific genes with a conserved domain, DUF243. TwdlE overexpression causes a Tubby-like phenotype similar to a mutant in the related TwdlD." FBgn0031955 Alliance Predicted to enable microtubule binding activity. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A) and KIF26B (kinesin family member 26B). FBgn0020618 FlyBase Gene Snapshot "Receptor of activated protein kinase C 1 (Rack1) encodes a cytosolic adaptor protein that is essential during development, particularly oogenesis." FBgn0031986 Alliance "Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in adult head. Orthologous to several human genes including B3GALT2 (beta-1,3-galactosyltransferase 2)." FBgn0031988 Alliance "Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Involved in synaptic target recognition. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal ectoderm anlage; embryonic epipharynx; and primordial germ cell. Orthologous to human B3GALT1 (beta-1,3-galactosyltransferase 1); B3GALT2 (beta-1,3-galactosyltransferase 2); and B3GALT5 (beta-1,3-galactosyltransferase 5)." FBgn0031996 Alliance Predicted to enable oligosaccharide binding activity. Predicted to be involved in carbohydrate metabolic process. Located in endomembrane system. Is expressed in adult head. Orthologous to human CHID1 (chitinase domain containing 1). FBgn0031997 FlyBase Gene Snapshot Post-GPI attachment to proteins 5 (PGAP5) encodes a protein that belongs to a dimetal-containing phosphoesterase family and catalyzes the remodeling of the glycan moiety on glycosylphosphatidylinositol (GPI)-anchored proteins. Its catalytic activity is a prerequisite for the efficient exit of GPI-anchor proteins from the ER. FBgn0031999 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in spermatozoon. Orthologous to human TRIM45 (tripartite motif containing 45). FBgn0015299 UniProtKB "General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity). Binds specifically to the NssBF element, a short nucleotide sequence of the 1731 retrotransposon, to repress promoter activity. (UniProtKB:Q9VLR5)" FBgn0032002 Alliance "Predicted to enable cytidine deaminase activity and zinc ion binding activity. Predicted to be involved in cytidine deamination. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm; embryonic primordium of adult muscle precursor; embryonic/larval midgut primordium; embryonic/larval muscle system; and gland. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase)." FBgn0032003 Alliance Predicted to enable cytidine deaminase activity and zinc ion binding activity. Predicted to be involved in cytidine deamination. Predicted to be active in cytosol. Is expressed in primary spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). FBgn0011902 Alliance Predicted to enable AAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0032013 Alliance "Predicted to be a structural constituent of muscle. Predicted to be located in membrane. Predicted to be part of sarcoglycan complex. Is expressed in several structures, including dorsal sensory complex proper primordium; embryonic epidermis; embryonic/larval muscle cell; ganglia; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D; muscular dystrophy; and myoclonic dystonia 11. Orthologous to human SGCA (sarcoglycan alpha) and SGCE (sarcoglycan epsilon)." FBgn0032014 UniProtKB Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). (UniProtKB:Q9VLP9) FBgn0032016 UniProtKB "Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:28675155). In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:28675155). M6A methylation is also required for neuronal functions (PubMed:27919077). (UniProtKB:Q9VLP7)" FBgn0032018 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10). FBgn0032020 FlyBase Gene Snapshot "stratum (strat) encodes an ortholog of the human guanine nucleotide exchange factor RABIF. Together with the product of Rab8, it regulates proper secretion of basement membrane proteins on the basal side of epithelial cells." FBgn0032022 Alliance "Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic anal pad; and embryonic/larval fat body." FBgn0032025 Alliance "Is expressed in several structures, including adult head; embryonic anal pad; embryonic head epidermis; embryonic large intestine; and gut section." FBgn0051901 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval Malpighian tubule; embryonic/larval gut; embryonic/larval proventriculus; embryonic/larval salivary gland; and organism. FBgn0032026 Alliance Enables ABC-type heme transporter activity. Involved in heme export. Located in plasma membrane. Is expressed in adult head. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0032021 Alliance Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in adult head. FBgn0032017 Alliance Orthologous to human CCDC97 (coiled-coil domain containing 97). FBgn0032015 FlyBase Gene Snapshot Oligosaccharide transferase gamma subunit (Ostgamma) encodes a subunit of the oligosaccharyltransferase complex involved in cell migration and cellular encapsulation response. FBgn0003502 FlyBase Gene Snapshot "Bruton tyrosine kinase (Btk) encodes a non-receptor tyrosine kinase with diverse roles including cellularization, morphogenesis, patterning and germ cell proliferation." FBgn0032010 Alliance Involved in sensory perception of sound. Predicted to be active in cytoskeleton. Is expressed in Johnston organ. FBgn0028987 FlyBase Gene Snapshot Serpin 28F (Spn28F) encodes a predicted serine protease inhibitor. It is expressed in the male accessory glands and transferred to females during mating. FBgn0032006 FlyBase Gene Snapshot "PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner." FBgn0032005 Alliance "Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in phagosome-lysosome fusion involved in apoptotic cell clearance and retrograde transport, endosome to Golgi. Predicted to be located in endosome. Predicted to be part of retromer, tubulation complex. Is expressed in adult head; adult heart; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human SNX32 (sorting nexin 32); SNX5 (sorting nexin 5); and SNX6 (sorting nexin 6)." FBgn0032004 Alliance Is expressed in spermatozoon. FBgn0032000 Alliance Is expressed in organism. Orthologous to human TMEM222 (transmembrane protein 222). FBgn0003607 UniProtKB "Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Stabilizes chromatin-associated RNAs probably by binding to them and thereby preventing their degradation (PubMed:26389589). Associates with, and may be a part of, the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion (PubMed:12510197, PubMed:20057353). Telomere capping is independent of the origin recognition complex (ORC) (PubMed:12510197). (UniProtKB:P05205)" FBgn0031998 FlyBase Gene Snapshot Sodium/solute co-transporter-like 5A11 (SLC5A11) encodes a protein involved in behavioral response to nutrient. FBgn0031992 Alliance "Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in several structures, including embryonic Malpighian tubule; embryonic/larval muscle system; gut section; and trunk mesoderm. Orthologous to several human genes including ACBD7 (acyl-CoA binding domain containing 7)." FBgn0031990 FlyBase Gene Snapshot Phosphatidic Acid Phospholipase A1 (PAPLA1) encodes a protein required for the endoplasmic reticulum to Golgi trafficking of a family of G-protein coupled receptors. FBgn0031987 Alliance Predicted to enable RNA endonuclease activity and single-stranded RNA binding activity. Predicted to be active in mitochondrial matrix. Is expressed in embryonic/larval midgut and organism. Orthologous to human LACTB2 (lactamase beta 2). FBgn0031985 UniProtKB May be required for traffic between late Golgi and early endosomes. (UniProtKB:Q9VLT1) FBgn0032029 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic dorsal epidermis; embryonic ventral epidermis; and embryonic/larval oenocyte. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0032030 FlyBase Gene Snapshot "WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3." FBgn0032032 Alliance Predicted to enable phosphatase activity. Orthologous to human HDHD2 (haloacid dehalogenase like hydrolase domain containing 2). FBgn0032034 FlyBase Gene Snapshot Reduction in Cnn dots 4 (Rcd4) encodes a protein involved in the regulation of the number of centrosomes per cell. FBgn0032036 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0041717 Alliance "Predicted to enable U4atac snRNA binding activity and pre-mRNA 5'-splice site binding activity. Involved in mRNA splicing, via spliceosome. Predicted to be part of U6atac snRNP." FBgn0020497 FlyBase Gene Snapshot embargoed (emb) encodes an exportin involved in protein export from the nucleus. It regulates the response to hypoxia and is involved in centriole replication. FBgn0027932 FlyBase Gene Snapshot A kinase anchor protein 200 (Akap200) encodes a scaffolding protein that contributes to the spatial and temporal regulation of the Protein Kinase A holoenzyme. It regulates the Notch signaling and the organization of the actin cytoskeleton. FBgn0053194 Alliance Involved in detection of pheromone and sensory perception of chemical stimulus. Predicted to be located in extracellular region. Is expressed in organism subdivision. FBgn0051896 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0032047 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism. FBgn0032052 FlyBase Gene Snapshot "Phosphatidylinositol glycan anchor biosynthesis class U (PIG-U) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane." FBgn0032054 FlyBase Gene Snapshot Molybdenum cofactor synthesis 3 (Mocs3) encodes a protein involved in molybdopterin cofactor synthesis and protein urmylation. FBgn0032055 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Located in peroxisomal membrane. Is expressed in adult fat body; adult head; and adult heart. FBgn0016122 FlyBase Gene Snapshot Angiotensin-converting enzyme-related (Acer) encodes an enzyme with peptidyl-dipeptidase activity that regulates heart rate and circadian sleep/wake cycle. FBgn0028394 Alliance "Is expressed in several structures, including adult head; anal pad primordium; embryonic anal pad; gut section; and posterior midgut primordium." FBgn0051603 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011259 FlyBase Gene Snapshot "Semaphorin 1a (Sema1a) encodes a transmembrane protein belonging to the semaphorin protein family. It is a repulsive axon guidance cue, signaling through direct interactions with the receptor encoded by PlexA, and also functions as a receptor to regulate dendrite targeting and axon guidance. Secreted semaphorins encoded by Sema2a and Sema2b can act as the product of Sema1a ligands." FBgn0051895 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051602 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051604 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0032053 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrial ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human MRPL51 (mitochondrial ribosomal protein L51)." FBgn0032051 Alliance Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Predicted to be part of Mpp10 complex and small-subunit processome. Orthologous to human MPHOSPH10 (M-phase phosphoprotein 10). FBgn0032050 Alliance Is expressed in adult head. Orthologous to human RSL1D1 (ribosomal L1 domain containing 1). FBgn0032048 FlyBase Gene Snapshot "Diuretic hormone 31 (Dh31) encodes a neuropeptide which regulates fluid secretion and controls the switch between feeding and courtship behaviour. Dh31 levels increase following the consumption of protein-rich food. In the brain Dh31 excites two distinct populations of neurons, responsible for two parallel pathways, one inhibiting feeding through AstC and the other promoting courtship through Crz." FBgn0032049 FlyBase Gene Snapshot "beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease." FBgn0051892 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0026718 Alliance Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in behavioral response to ethanol. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; amnioserosa; embryonic/larval midgut; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). FBgn0027490 FlyBase Gene Snapshot D12 (D12) encodes a protein involved in chromatin remodeling and histone acetylation. FBgn0001137 FlyBase Gene Snapshot "gurken (grk) encodes a TGFalpha family signaling ligand that activates the intracellular MAP kinase pathway via the the product of Egfr. The asymmetrical localization of grk mRNA is key for its function during oogenesis, to establish anterior-posterior and dorso-ventral axes in the egg and embryo." FBgn0032042 Alliance Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut; organism; wing hinge primordium; and wing pouch. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2) and FRS3 (fibroblast growth factor receptor substrate 3). FBgn0014417 Alliance Predicted to enable alpha-N-acetylglucosaminidase activity. Predicted to be involved in heparan sulfate proteoglycan catabolic process. Is active in lysosomal lumen. Is expressed in adult fat body; adult head; and adult heart. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase). FBgn0001084 FlyBase Gene Snapshot fuzzy (fy) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity in the adult. It interacts directly with the product of in and accumulates on the proximal edge of wing cells. FBgn0040959 Alliance Predicted to enable chitin binding activity. Predicted to be a structural constituent of peritrophic membrane. Predicted to be located in chitin-based extracellular matrix. FBgn0040958 Alliance Predicted to enable chitin binding activity. Predicted to be a structural constituent of peritrophic membrane. Predicted to be located in chitin-based extracellular matrix. FBgn0040098 Alliance Predicted to enable galactose binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0015583 FlyBase Gene Snapshot "Accessory gland protein 29AB (Acp29AB) encodes a predicted C-type lectin that is produced by the male accessory glands and transferred to females during mating. After transfer to mated females, the Acp29AB product is detected in sperm storage organs and in the hemolymph. It plays a role in retention of sperm in storage and sperm competition." FBgn0032033 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 29 and optic atrophy 7. Orthologous to human TMEM126A (transmembrane protein 126A) and TMEM126B (transmembrane protein 126B). FBgn0032031 Alliance Predicted to enable GTP binding activity and GTPase activity. Predicted to be active in mitochondrion. Is expressed in embryonic/larval midgut. Orthologous to human MTG2 (mitochondrial ribosome associated GTPase 2). FBgn0001114 FlyBase Gene Snapshot Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth. FBgn0051889 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051890 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0032061 Alliance "Predicted to enable catalase activity and heme binding activity. Predicted to be involved in hydrogen peroxide catabolic process and response to hydrogen peroxide. Predicted to be active in mitochondrion and peroxisome. Is expressed in adult head; spermatozoon; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase)." FBgn0029123 FlyBase Gene Snapshot "SoxNeuro (SoxN) encodes an HMG-domain transcription factor. In early embryos it specifies neural progenitors in the central nervous system, while in later embryos it negatively regulates Wg signaling and controls expression of genes required for denticle construction with the product of ovo." FBgn0032069 Alliance Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in adult head; embryonic/larval midgut; embryonic/larval posterior spiracle; and posterior spiracle primordium. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). FBgn0032068 Alliance Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in adult head; embryonic hindgut; embryonic midgut chamber; embryonic/larval midgut; and spermatozoon. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). FBgn0032067 Alliance Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in adult heart. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). FBgn0032066 Alliance Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). FBgn0003209 FlyBase Gene Snapshot raw (raw) encodes a membrane protein involved in dendrite patterning and the subcellular localization of JNK signalling components. FBgn0004914 FlyBase Gene Snapshot "Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function." FBgn0032059 Alliance Predicted to be involved in sensory perception of light stimulus. Located in cytoplasm and nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and organism. Human ortholog(s) of this gene implicated in Joubert syndrome 22. Orthologous to human PDE6D (phosphodiesterase 6D). FBgn0051888 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0032074 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic midgut chamber; and embryonic/larval midgut. Orthologous to human CD63 (CD63 molecule). FBgn0032075 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human CD63 (CD63 molecule); TSPAN6 (tetraspanin 6); and TSPAN7 (tetraspanin 7). FBgn0052985 Alliance Involved in sexual reproduction. Is expressed in adult head. FBgn0052984 Alliance Is expressed in adult fat body and adult head. FBgn0032082 Alliance Is expressed in amnioserosa. FBgn0040963 Alliance Predicted to enable protein histidine phosphatase activity. Predicted to be active in cytosol. Is expressed in spermatozoon. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). FBgn0032085 Alliance Predicted to be active in membrane. FBgn0032086 Alliance Predicted to be active in membrane. FBgn0040964 Alliance Predicted to enable methyltransferase activity. Is expressed in spermatozoon. Orthologous to human METTL26 (methyltransferase like 26). FBgn0015316 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). FBgn0032087 Alliance Is expressed in embryonic Malpighian tubule; embryonic main segment of Malpighian tubule; embryonic midgut chamber; embryonic/larval midgut; and gastric caecum. FBgn0032088 Alliance Is expressed in embryonic midgut chamber and embryonic/larval midgut. FBgn0032095 FlyBase Gene Snapshot Toll-4 (Toll-4) encodes a putative transmembrane protein related to Toll by virtue of containing intracellular TIR domain and extracellular Leucine-rich repeats. It is expressed in the apical part of the embryonic lymph gland precursors. FBgn0051609 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0032096 FlyBase Gene Snapshot Odorant receptor 30a (Or30a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0052982 Alliance "Predicted to be involved in actin cytoskeleton organization. Predicted to be active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; endoderm anlage; ganglia; and mesoderm." FBgn0032101 Alliance Is expressed in organism. Orthologous to human CCDC43 (coiled-coil domain containing 43). FBgn0051708 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in proximal medullary amacrine neuron Pm2; transmedullary Y neuron TmY10; and transmedullary neuron Tm20. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). FBgn0032090 Alliance Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21). FBgn0032089 Alliance "Involved in spermatogenesis. Located in nucleus. Is expressed in several structures, including adult descending neurons; brain; gonad; larval central brain; and male germline cell. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9)." FBgn0013746 FlyBase Gene Snapshot "alien (alien) encodes the subunit 2 of the COP9 signalosome, which plays a central role in the regulation of E3-cullin RING ubiquitin ligases." FBgn0011705 UniProtKB "May have a central role in the fusion process during myogenesis, within the somatic mesoderm. (UniProtKB:O44252)" FBgn0032084 Alliance Predicted to be active in membrane. Is expressed in anterior endoderm anlage and posterior endoderm anlage. FBgn0032083 Alliance Predicted to enable (d)CMP kinase activity and UMP kinase activity. Predicted to be involved in CDP biosynthetic process and UDP biosynthetic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human AK5 (adenylate kinase 5). FBgn0032080 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. Is expressed in adult head. FBgn0032079 FlyBase Gene Snapshot CG31886 encodes a protein that regulates ethanol sedation sensitivity. FBgn0032078 FlyBase Gene Snapshot "Core 1 Galactosyltransferase A (C1GalTA) encodes a protein that exhibits strong core 1beta1,3GalT activity, and is involved in the synthesis of T antigen in hemocytes. Its roles include hematopoietic stem cell maintenance, neural network and neuromuscular junction formation." FBgn0041092 FlyBase Gene Snapshot taiman (tai) encodes an ecdysone receptor co-activator related to mammalian steroid receptor coactivator (SRC) proteins. It contributes to border cell migration. FBgn0010314 FlyBase Gene Snapshot "Cyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA." FBgn0026439 FlyBase Gene Snapshot Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan. FBgn0012036 FlyBase Gene Snapshot "Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol." FBgn0032116 FlyBase Gene Snapshot "Multicopper oxidase 1 (Mco1) encodes a plasma membrane-bound multicopper oxidase that is positioned to oxidize substrates in the hemolymph, such as ascorbate, and its biological role is unknown." FBgn0011232 FlyBase Gene Snapshot scattered (scat) encodes a component of the Golgi-Associated Retrograde Protein (GARP) complex and is required for spermatid development. It is important for secretory granule maturation and for preventing early degradation of these granules. FBgn0032119 Alliance Predicted to enable dynein heavy chain binding activity. Predicted to be involved in intraciliary retrograde transport and intraciliary transport involved in cilium assembly. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in axoneme and ciliary basal body. Is expressed in chordotonal organ precursor cell and external sensory organ precursor cell. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1). FBgn0032115 Alliance Predicted to enable RNA binding activity. Predicted to be active in cytosol. Orthologous to human PDAP1 (PDGFA associated protein 1). FBgn0032105 FlyBase Gene Snapshot "borealin-related (borr) encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex. It helps to target the complex to the centromere region of chromosomes and the cleavage furrow during cytokinesis. At centromeres the complex is involved both in pausing mitotic progression when there are chromosome mis-attachments and in correcting those mis-attachments. At the cleavage furrow, the complex is involved in regulating the process of abscission (cell separation)." FBgn0032104 FlyBase Gene Snapshot "australin (aust) is a male meiotic specific paralogue of borr, which encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex (CPC). The CPC is critical in regulating multiple aspects of cell division, including chromosome condensation, kinetochore function and cytokinesis, through the kinase activity of the product of aurB." FBgn0051885 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0002973 FlyBase Gene Snapshot numb (numb) encodes a membrane-associated inhibitor of Notch signaling. It controls neuroblast and sense organ precursor asymmetric division. It is asymmetrically localized during mitosis and segregates exclusively to one of two daughter cells. FBgn0032123 FlyBase Gene Snapshot Organic anion transporting polypeptide 30B (Oatp30B) encodes a transmembrane transporter involved in the transport of the cardiac glycoside ouabain. FBgn0032122 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in male accessory gland. FBgn0032125 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head. FBgn0032126 Alliance Involved in egg chorion assembly. FBgn0032127 Alliance Located in egg chorion. FBgn0032131 Alliance Enables serine hydrolase activity. Is expressed in adult head. Orthologous to human CES5A (carboxylesterase 5A). FBgn0019809 FlyBase Gene Snapshot "gcm2 (gcm2) encodes an atypical zinc finger transcription factor. It has a redudant role with the product of gcm in the differentiation of glial cells, plasmatocytes and tendon cells differentiation." FBgn0040070 UniProtKB "Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. (UniProtKB:Q9V429)" FBgn0032135 UniProtKB Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity. (UniProtKB:Q9VLA1) FBgn0032136 FlyBase Gene Snapshot "Apolipoprotein lipid transfer particle (Apoltp) encodes a apolipoprotein of the ApoB family. It is assembled with lipids to form high density, low abundance lipoproteins named lipid transfer particles (LTP). LTP catalyzes the transfer of lipids from the gut to circulating lipophorin and from lipophorin to peripheral tissues, such as imaginal discs and ovaries." FBgn0011207 UniProtKB "Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:29861391). In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Pelota-HBS1L complex promotes recruitment of pix, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis (PubMed:7588080). Together with HBS1, promotes spermatid individualization during spermatogenesis (PubMed:30824860). Required for ovarian germ line stem cell self-renewal and oocyte development during oogenesis (PubMed:16280348). Together with HSB1, required for transposon silencing in the ovary and testis (PubMed:26124316). As part of the Pink1-regulated signaling, is recruited to damaged mitochondrial and is required for recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). Required for normal eye patterning and for mitotic divisions in the ovary (PubMed:7588080). (UniProtKB:P48612)" FBgn0032138 UniProtKB Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. (UniProtKB:Q9VL96) FBgn0000273 FlyBase Gene Snapshot "Protein kinase, cAMP-dependent, catalytic subunit 1 (Pka-C1) encodes a serine/threonine kinase that contributes to axis specification, rhythmic behavior and synaptic transmission." FBgn0032132 Alliance Is expressed in wing disc. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0014179 FlyBase Gene Snapshot "glial cells missing (gcm) encodes an essential zinc finger transcription factor that determines the fate of the lateral glial cells. It is involved in the differentiation of plasmatocytes, tendon cells and specific neurons." FBgn0028479 FlyBase Gene Snapshot "Mitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids." FBgn0032129 FlyBase Gene Snapshot "junctophilin (jp) belongs to a gene family encoding proteins anchored to the endoplasmic reticulum through a transmembrane region. The product of jp contributes to the formation and maintenance of junctional membrane complexes. It serves as a physical bridge between the plasma membrane and the endoplasmic reticulum in excitable cells, allowing the functional crosstalk between ion channels. It is necessary for calcium signalling in muscle contraction and neuronal communication." FBgn0004868 FlyBase Gene Snapshot GDP dissociation inhibitor (Gdi) encodes a GDP-dissociation inhibitor. FBgn0032143 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic tracheole. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to several human genes including CPA1 (carboxypeptidase A1); CPA2 (carboxypeptidase A2); and CPA4 (carboxypeptidase A4). FBgn0032144 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and spermatozoon. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA1 (carboxypeptidase A1); CPA2 (carboxypeptidase A2); and CPA5 (carboxypeptidase A5). FBgn0032147 FlyBase Gene Snapshot "Inositol 1,4,5-triphosphate kinase 1 (IP3K1) encodes a protein involved in response to oxidative stress." FBgn0032149 Alliance "Predicted to enable broad specificity oxidative DNA demethylase activity. Involved in larval lymph gland hemopoiesis. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval posterior spiracle. Orthologous to human ALKBH4 (alkB homolog 4, lysine demethylase)." FBgn0032169 UniProtKB Transcription repressor. (UniProtKB:Q9VL59) FBgn0032170 Alliance Is expressed in adult head and organism. FBgn0032172 Alliance "Predicted to be active in membrane. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval fat body; and head mesoderm. Orthologous to human TMEM184C (transmembrane protein 184C)." FBgn0032171 Alliance Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to several human genes including RFXANK (regulatory factor X associated ankyrin containing protein). FBgn0032168 Alliance "Predicted to enable methyltransferase activity. Predicted to be involved in translation. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle cell. Orthologous to human METTL17 (methyltransferase like 17)." FBgn0025881 FlyBase Gene Snapshot C/D box small nucleolar RNA 7 (snoRNA:CD7) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G2666 in 28SrRNA:CR45844. FBgn0063389 FlyBase Gene Snapshot C/D box small nucleolar RNA 8 (snoRNA:CD8) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1621 in 18SrRNA:CR45838. FBgn0063392 FlyBase Gene Snapshot C/D box small nucleolar RNA 9a (snoRNA:CD9a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1005 in 28SrRNA:CR45844. FBgn0063391 FlyBase Gene Snapshot C/D box small nucleolar RNA 9b (snoRNA:CD9b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0032150 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0011291 FlyBase Gene Snapshot "TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex." FBgn0015035 FlyBase Gene Snapshot Cytochrome P450-4e3 (Cyp4e3) encodes an endoplasmic reticulum protein that plays a role in insecticide tolerance. Upon insecticide feeding Cyp4e3 is significantly up-regulated. Cyp4e3 knockdown in the Malpighian tubule principal cells reduces survival of insecticide-fed flies. Cyp4e3 protein may also regulate hydrogen peroxide levels in the endoplasmic reticulum and its absence triggers JAK/STAT and NF-kappaB-mediated stress responses. FBgn0028704 UniProtKB May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+). (UniProtKB:Q9U6A0) FBgn0000180 FlyBase Gene Snapshot big brain (bib) encodes a non-selective cation channel in the aquaporin family. Its function is required for optimal Notch signaling to restrain neurogenesis. FBgn0043456 FlyBase Gene Snapshot "Nucleosome-destabilizing factor (Ndf) encodes a putative H3K36me3 binding protein, which binds active gene bodies." FBgn0011584 Alliance "Predicted to enable protein transmembrane transporter activity. Involved in post-translational protein targeting to membrane, translocation. Located in endomembrane system. Part of Sec62/Sec63 complex. Is expressed in several structures, including adult head; adult heart; ejaculatory duct; gonad; and male accessory gland. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor)." FBgn0027600 Alliance "Predicted to enable chitin binding activity. Predicted to be located in chitin-based extracellular matrix. Is expressed in several structures, including embryonic dorsal epidermis; embryonic head epidermis; embryonic hypopharynx; embryonic ventral epidermis; and primary tracheal branch." FBgn0053302 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in wing disc. FBgn0032178 Alliance Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human SERPINA7 (serpin family A member 7). FBgn0032187 Alliance Predicted to enable cGMP-dependent protein kinase activity. Predicted to be involved in protein kinase A signaling. Predicted to be located in cytoplasm and plasma membrane. Is expressed in adult brain; adult head; embryonic midgut chamber; and embryonic/larval midgut. FBgn0032188 Alliance Predicted to be involved in nucleocytoplasmic transport. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in achalasia and triple-A syndrome. Orthologous to human AAAS (aladin WD repeat nucleoporin). FBgn0005593 UniProtKB Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). (UniProtKB:P32100) FBgn0032194 FlyBase Gene Snapshot athos (ath) encodes an ATP-dependent RNA helicase involved in neurogenesis and spliceosomal complex disassembly. FBgn0032195 Alliance "Predicted to enable ATP hydrolysis activity and mitochondrial protein-transporting ATPase activity. Involved in mitochondrial respiratory chain complex III assembly and protein insertion into mitochondrial inner membrane from matrix. Is active in mitochondrion. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut interstitial cell; embryonic/larval midgut primordium; and gut section. Used to study mitochondrial complex III deficiency nuclear type 1. Human ortholog(s) of this gene implicated in Bjornstad syndrome; GRACILE syndrome; and mitochondrial complex III deficiency nuclear type 1. Orthologous to human BCS1L (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone)." FBgn0032198 UniProtKB EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (UniProtKB:Q9VL18) FBgn0032197 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0032196 Alliance Predicted to be involved in leg disc development. Predicted to be located in nucleus. Is expressed in wing hinge primordium and wing pouch. Orthologous to human LMO4 (LIM domain only 4). FBgn0024320 FlyBase Gene Snapshot Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization. FBgn0032192 Alliance Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process and oligosaccharide metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). FBgn0032191 Alliance Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX17 (sorting nexin 17). FBgn0032189 Alliance Predicted to be involved in protein import into nucleus. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human RPAIN (RPA interacting protein). FBgn0028675 FlyBase Gene Snapshot Sulfonylurea receptor (Sur) encodes a predicted ATP-sensitive K[+] channel expressed almost exclusively in the embryonic heart. Sur loss in the adult heart causes increased oxidative stress and pacing-induced heart failure. FBgn0051874 Alliance Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). FBgn0032181 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein folding; protein refolding; and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in Johnston organ. Human ortholog(s) of this gene implicated in cataract 16 multiple types; cataract 9 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAA (crystallin alpha A) and CRYAB (crystallin alpha B). FBgn0032175 Alliance Predicted to be active in cytoplasm and nucleus. Is expressed in spermatozoon. FBgn0051755 FlyBase Gene Snapshot Sister of Yb (SoYb) encodes a putative RNA helicase in the TDRD12 family. It has an essential role in primary piRNA biogenesis in ovarian somatic cells and is predicted to also have a role in germline piRNA biogenesis. FBgn0051875 Alliance Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. FBgn0004419 UniProtKB "ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission (PubMed:11546740, PubMed:16256742, PubMed:17178403, PubMed:17982591, PubMed:18590813, PubMed:21267420, PubMed:21447556, PubMed:28388438, PubMed:28875934, PubMed:31114929). Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies (PubMed:11546740, PubMed:16256742, PubMed:17178403, PubMed:17982591, PubMed:21267420, PubMed:21447556, PubMed:28875934). As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogenesis (PubMed:28875934). As part of a RNP complex containing tral and the RNA localization factors exu and yps, mediates translational silencing of mRNAs such as osk/oskar and bcd/bicoid during their transport to the oocyte in order to prevent their translation until they reach their positional destinations (PubMed:11546740). In neurons and possibly imaginal disks, involved in miRNA-mediated translational repression, possibly in association with components of the piRNA transposon silencing pathway (PubMed:17178403, PubMed:17982591, PubMed:21081899, PubMed:21267420, PubMed:21447556). Involved in RNA localization and protein trafficking in the oocyte (PubMed:11546740, PubMed:16256742). As part of an ER-associated RNP containing tral, cup and yps, required for tral-dependent ER exit site formation and consequently efficient trafficking of proteins such as grk and yl through the secretory pathway (PubMed:16256742). Component of neuron RNPs that mediate transport and translation of neuronal RNAs, including translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403, PubMed:21267420, PubMed:28388438). As part of the Atx2-Not1 repressor complex promotes Not1-dependent post-transcriptional gene silencing in adult circadian pacemaker neurons in order to sustain high-amplitude circadian rhythms and Pdf cycling in a per-independent manner (PubMed:28388438). Promotes the interaction between Atx2 and Not1 within the Atx2-Not1 RNP complex (PubMed:28388438). Recruited to the 4EHP-GYF2 complex by Gyf, where it plays a role in 4EHP-GYF2 mediated translational repression and mRNA decay (PubMed:31114929). (UniProtKB:P23128)" FBgn0051717 Alliance Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human PLPP6 (phospholipid phosphatase 6) and PLPP7 (phospholipid phosphatase 7 (inactive)). FBgn0010407 FlyBase Gene Snapshot Ror (Ror) encodes a transmembrane receptor tyrosine kinase structurally related to vertebrate neural-specific Wnt-binding Ror receptors. It is primarily expressed in the nervous system and it is likely to signal through the ERK MAP kinase pathway. FBgn0032204 Alliance Predicted to be involved in Golgi vesicle transport. Located in Golgi apparatus. Part of TRAPPIII protein complex. Is expressed in adult head and organism. Orthologous to human TRAPPC13 (trafficking protein particle complex subunit 13). FBgn0032205 Alliance Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 8. Orthologous to human TACO1 (translational activator of cytochrome c oxidase I). FBgn0032214 UniProtKB Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. (UniProtKB:Q9VL00) FBgn0032217 Alliance "Predicted to be involved in regulation of signal transduction. Located in endomembrane system. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to human NCLN (nicalin)." FBgn0032219 Alliance Predicted to enable high-affinity L-arginine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human SLC25A29 (solute carrier family 25 member 29). FBgn0032222 Alliance "Predicted to enable protoheme IX farnesyltransferase activity. Predicted to be involved in heme A biosynthetic process and respiratory chain complex IV assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; embryonic/larval muscle system; and gut section. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10)." FBgn0032223 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate commitment; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in organism." FBgn0019932 FlyBase Gene Snapshot S-adenosylmethionine decarboxylase (SamDC) encodes a protein involved in defense response to Gram-negative bacterium. FBgn0051715 Alliance Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in regulation of barbed-end actin filament capping. Predicted to be part of F-actin capping protein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Orthologous to human MTPN (myotrophin). FBgn0032224 FlyBase Gene Snapshot Selenophosphate synthetase 2 (Sps2) is essential for selenoprotein biosynthesis. It encodes an enzyme that catalyzes the synthesis of selenophosphate from selenide and/or other selenium metabolites. Selenophosphate is an active selenium donor for the formation of selenocysteine. FBgn0032225 Alliance "Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be active in cytoskeleton. Is expressed in several structures, including adult antennal lobe; adult head; adult mushroom body; adult optic lobe; and larval ventral nerve cord. Used to study neurodevelopmental disorder with eye movement abnormalities and ataxia. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to several human genes including FRMD5 (FERM domain containing 5)." FBgn0032229 Alliance "Enables serine hydrolase activity. Involved in proteolysis involved in protein catabolic process and regulation of mitochondrial gene expression. Part of endopeptidase Clp complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit)." FBgn0003087 FlyBase Gene Snapshot "pimples (pim) encodes the Drosophila Securin homolog. Securins bind to the endoprotease Separase. In some species including Drosophila, this binding appears to promote proper folding of Separase. In addition, securin binding inhibits separase endoprotease activity in all species via an inhibitory pseudosubstrate region." FBgn0032230 FlyBase Gene Snapshot lowfat (lft) encodes a protein that influences Dachsous-Fat signaling by elevating levels of the products of ds and ft at apical membranes. Mutation of lft causes mild planar cell polarity and growth phenotypes. FBgn0032231 Alliance Predicted to be involved in cellular response to hydrogen peroxide. Is expressed in organism. Orthologous to human OSER1 (oxidative stress responsive serine rich 1). FBgn0032233 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. FBgn0032234 FlyBase Gene Snapshot garnysstan (gny) encodes a glucosyltransferase involved in cuticle barrier formation and thought to have a role in N-glycan biosynthesis and epidermal differentiation. FBgn0032235 Alliance Is expressed in adult head and wing disc. FBgn0032236 Alliance "Predicted to enable mRNA binding activity and rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation and ribosomal small subunit assembly. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in ribosome. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 34. Orthologous to human MRPS7 (mitochondrial ribosomal protein S7)." FBgn0051716 FlyBase Gene Snapshot CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E. FBgn0051718 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Is expressed in adult olfactory receptor neuron Ir31a; antennal coeloconic sensillum ac1; and antennal lobe glomerulus VL2p. FBgn0003942 Alliance "A structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process; protein ubiquitination; and ribosomal small subunit biogenesis. Located in cytosolic ribosome. Is expressed in several structures, including Malpighian tubule; embryonic/larval fat body; embryonic/larval salivary gland; germinal proliferation center; and ovary. Orthologous to human RPS27A (ribosomal protein S27a) and RPS27AP5 (ribosomal protein S27a pseudogene 5)." FBgn0025366 Alliance "Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human NSA2 (NSA2 ribosome biogenesis factor)." FBgn0032243 Alliance Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A) and KIF21B (kinesin family member 21B). FBgn0032244 Alliance Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair; leading strand elongation; and sister chromatid cohesion. Part of Elg1 RFC-like complex. Is expressed in organism. Orthologous to human RFC5 (replication factor C subunit 5). FBgn0032246 Alliance Enables protein kinase binding activity. Located in endosome. Is expressed in adult head; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human WDFY1 (WD repeat and FYVE domain containing 1) and WDFY2 (WD repeat and FYVE domain containing 2). FBgn0032247 Alliance "Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Is expressed in adult heart. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial)." FBgn0004915 FlyBase Gene Snapshot Transcription factor IIB (TfIIB) encodes a basal transcription factor that binds to the TATA box-binding protein. It is required for the initiation of transcription by RNA polymerase II. FBgn0032250 FlyBase Gene Snapshot hole-in-one (holn1) encodes a protein involved in wound healing. FBgn0027052 FlyBase Gene Snapshot STIP1 homology and U-box containing protein 1 (STUB1) encodes a ubiquitin protein ligase involved in insulin signaling pathway regulation and protein ubiquitination. FBgn0032251 FlyBase Gene Snapshot "Non-SMC element 4 (Nse4) encodes a member of the EID (EP300-interacting inhibitor of differentiation) family of proteins. It is the kleisin component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes." FBgn0032252 FlyBase Gene Snapshot lonely heart (loh) encodes a protein involved in larval heart development and regulation of the extracellular matrix assembly. FBgn0027611 FlyBase Gene Snapshot "Lysosomal alpha-mannosidase II (LManII) encodes a mannosyl-oligosaccharide 1,2-alpha-mannosidase involved in the degradation of asparagine-linked carbohydrates of glycoproteins." FBgn0032256 Alliance Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis. Is expressed in larval dorsal multidendritic neurons and organism. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). FBgn0026431 UniProtKB Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. (UniProtKB:Q9VKU7) FBgn0032260 Alliance Predicted to enable structural molecule activity. FBgn0032258 UniProtKB Required for normal Golgi function. (UniProtKB:Q95TN4) FBgn0051719 FlyBase Gene Snapshot "RluA pseudouridine synthase 1 (RluA-1) encodes a pseudouridine synthase, an enzyme catalyzing the formation of the most abundant nucleoside modification of RNA, pseudouridine." FBgn0032253 FlyBase Gene Snapshot Lysosomal alpha-mannosidase I (LManI) encodes an enzyme that is involved in mannose metabolism using p-nitrophenyl-alpha-mannoside as a substrate. FBgn0032249 Alliance Predicted to enable GTPase activator activity. Predicted to be active in early endosome. Orthologous to human TBC1D16 (TBC1 domain family member 16). FBgn0032248 FlyBase Gene Snapshot "Basal body up regulated gene 22 (Bug22) encodes a ciliary protein involved in cilium organization and assembly. It contributes to multiple processes during spermatogenesis including tubulin polyglycylation, axoneme assembly, sperm individualization and motility. It also contributes to locomotion, dendrite morphogenesis and neuron and muscle development." FBgn0005683 FlyBase Gene Snapshot pineapple eye (pie) encodes a protein that contributes to viability of imaginal disc cells and affects germline stem cell renewal. It interacts genetically with the Jak/Stat and BMP pathways. FBgn0032242 Alliance "Enables carboxylesterase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; central brain primordium; fat body/gonad primordium; and ganglia. Orthologous to human PREP (prolyl endopeptidase)." FBgn0004106 FlyBase Gene Snapshot "Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases." FBgn0053303 Alliance Predicted to be involved in protein N-linked glycosylation via asparagine. Located in endomembrane system. Is expressed in adult heart. Orthologous to human RPN1 (ribophorin I). FBgn0027568 UniProtKB "Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (Probable). (UniProtKB:Q9VKY2)" FBgn0032228 Alliance Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. FBgn0032221 FlyBase Gene Snapshot "Schwannomin interacting protein 1 (Schip1) encodes a protein that is involved in negative regulation of organ growth by promoting the Hippo signaling pathway. It binds to the products of ex and Tao, activating the phosphorylation of the kinase encoded by hpo." FBgn0011703 UniProtKB Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (UniProtKB:P48591) FBgn0032218 Alliance Is expressed in adult head; embryonic precursor of adult hindgut; embryonic/larval muscle cell; embryonic/larval muscle system; and gut section. FBgn0032216 FlyBase Gene Snapshot "Ubiquitin specific protease 14 (Usp14) encodes a deubiquitinase that associates with the 19S component of the proteasome in a reversible manner. Its functions include ubiquitin chain disassemblance for mono-ubiquitin recycling, control of protein degradation by the proteasome and regulation of proteasome subtrate interactions." FBgn0027491 FlyBase Gene Snapshot "Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration." FBgn0032213 Alliance Involved in melanization defense response and zymogen activation. Located in extracellular region. Is expressed in adult head; adult heart; amnioserosa; spermatozoon; and yolk nucleus. FBgn0005322 Alliance "Predicted to enable membrane protein dislocase activity. Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1)." FBgn0032210 Interactive Fly deubiquitinating enzyme that deubiquitinates dTRAF2 and prevents dTRAF2 from ubiquitin-mediated proteolytic degradation - involved in stress response - required for Eiger-triggered JNK activation and cell death FBgn0032209 FlyBase Gene Snapshot "Hand (Hand) encodes a transcription factor that contributes to cardiogenesis, hemopoiesis, and muscle function." FBgn0032208 UniProtKB E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662). (UniProtKB:Q9VL06) FBgn0003751 FlyBase Gene Snapshot trunk (trk) encodes one of its cleaved forms acts as the ligand for the receptor encoded by tor in the early embryo. FBgn0011305 UniProtKB May control important aspects of development. (UniProtKB:Q24491) FBgn0032200 Alliance Involved in mitophagy. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head and adult heart. Orthologous to several human genes including FUNDC2 (FUN14 domain containing 2). FBgn0000229 FlyBase Gene Snapshot "basket (bsk) encodes a serine/threonine-protein kinase, a key component of JNK pathway that phosphorylates the transcription factor encoded by Jra. Its roles include regulation of cell shape and stress response." FBgn0024248 FlyBase Gene Snapshot "chico (chico) encodes a substrate of the product of InR. As a key component of the Insulin pathway, the chico product plays an essential role in the control of cell size and growth." FBgn0032261 Alliance "Predicted to enable aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific. Predicted to be involved in mitochondrial translational termination. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut; and embryonic/larval visceral muscle cell. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58)." FBgn0010398 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in Ras protein signal transduction. Located in cytoplasm and nucleus. Is expressed in organism. Orthologous to human LRR1 (leucine rich repeat protein 1). FBgn0032264 Alliance Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in lipid droplet. Is expressed in adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0032265 Alliance Enables serine hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in lipid droplet. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0032266 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0051872 Alliance "Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic head sensory system; sensory nervous system primordium; and spermatozoon. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0043825 Alliance "Predicted to enable triglyceride lipase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and male accessory gland. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0051871 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Is expressed in several structures, including anal pad primordium; anlage in statu nascendi; dorsal ectoderm anlage; embryonic anal pad; and gut section. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0040496 Alliance Is expressed in embryonic dorsal epidermis; embryonic epipharynx; embryonic foregut; and embryonic ventral epidermis. FBgn0032281 Alliance Is expressed in embryonic/larval midgut and organism. FBgn0032287 Alliance Predicted to enable aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval fat body; fat body primordium; and fat body/gonad primordium. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). FBgn0032289 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0032290 Alliance Predicted to be involved in DNA replication termination. Predicted to be active in nucleus. Orthologous to human RTF2 (replication termination factor 2). FBgn0032291 Alliance Predicted to be involved in cilium assembly; positive regulation of cell motility; and regulation of cilium beat frequency involved in ciliary motility. Predicted to be active in ciliary basal body and motile cilium. Is expressed in adult head and spermatozoon. FBgn0032293 FlyBase Gene Snapshot "Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1." FBgn0032295 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium." FBgn0027550 Alliance Is expressed in adult head; embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. Orthologous to human LRP11 (LDL receptor related protein 11). FBgn0015320 UniProtKB Catalyzes the covalent attachment of ubiquitin to other proteins. (UniProtKB:P52485) FBgn0032297 Alliance "Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be located in cytoplasm. Is expressed in several structures, including embryonic brain; embryonic/larval muscle cell; gut section; sensory nervous system primordium; and visceral mesoderm derivative. Orthologous to several human genes including PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B)." FBgn0032296 UniProtKB Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity). (UniProtKB:Q9VKQ6) FBgn0032294 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c)." FBgn0027868 UniProtKB Plays a role in nuclear pore complex (NPC) assembly and maintenance (PubMed:20547758). Required for nuclear import of Mad (PubMed:20547758). Mediates the association between the nuclear pore complex and a subset of active chromatin regions adjacent to lamin-associated domains (PubMed:31784359). Plays a role in double strand break repair by relocalizing the heterochromatic double strand breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056). Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope (PubMed:27402967). Regulates female gonad development and oogenesis (PubMed:26485283). (UniProtKB:Q9V466) FBgn0032292 FlyBase Gene Snapshot "ER membrane protein complex subunit 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of single-pass and multi-pass membrane proteins, but not for secretory proteins." FBgn0024740 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0023496 UniProtKB Could be a digestive enzyme. (UniProtKB:O46107) FBgn0032286 Alliance Is expressed in embryonic maxillary sensory complex. FBgn0032285 Alliance Is expressed in adult head and organism. FBgn0032283 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic ventral epidermis; gnathal primordium; and larval foregut atrium." FBgn0032282 Alliance Is expressed in embryonic epipharynx; embryonic rectum; embryonic/larval fat body; epithelium; and yolk nucleus. FBgn0032271 Alliance Predicted to enable triglyceride lipase activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0032269 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0032262 Alliance Is expressed in adult head and organism. FBgn0032299 Alliance Is expressed in adult head. FBgn0032303 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Orthologous to several human genes including CTSE (cathepsin E); PGA3 (pepsinogen A3); and PGA4 (pepsinogen A4). FBgn0032304 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Orthologous to several human genes including CTSE (cathepsin E); PGA3 (pepsinogen A3); and PGA4 (pepsinogen A4). FBgn0027363 FlyBase Gene Snapshot "Signal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking." FBgn0032311 Alliance Predicted to enable cytokine activity. Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. Is expressed in adult fat body. FBgn0032321 UniProtKB "Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. (UniProtKB:Q9VKM6)" FBgn0032322 Alliance Is expressed in organism. FBgn0041781 FlyBase Gene Snapshot "SCAR (SCAR) encodes a primary regulator of the Arp2/3 complex, which promotes actin polymerization and influences cell shape and motility. It is involved in myoblast fusion, eye morphogenesis and axogenesis." FBgn0026148 Alliance Is expressed in organism. Orthologous to human HARBI1 (harbinger transposase derived 1). FBgn0026147 Alliance Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in wound healing. Predicted to be active in cilium. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). FBgn0040096 Alliance Predicted to enable galactose binding activity. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to several human genes including CLEC4A (C-type lectin domain family 4 member A); CLEC4C (C-type lectin domain family 4 member C); and CLEC4M (C-type lectin domain family 4 member M). FBgn0023415 FlyBase Gene Snapshot Accessory gland protein 32CD (Acp32CD) encodes a protein produced in the male accessory glands that is predicted to be secreted. FBgn0032331 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0032330 FlyBase Gene Snapshot SAM-motif ubiquitously expressed punctatedly localized protein (Samuel) encodes a protein that binds to the nuclear receptor encoded by Hr78 and acts as a corepressor. It regulates chromatin silencing and larval growth. FBgn0032329 FlyBase Gene Snapshot Arginine methyltransferase 8 (Art8) encodes a histone methyltransferase involved in methylation of both histone H3-R2 and arginine. FBgn0015756 FlyBase Gene Snapshot Ribosomal protein L9 (RpL9) encodes a ribosomal structural constituent. FBgn0000146 UniProtKB "Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with Su(Ste) antisense piRNAs (most abundant class of piRNAs found in complex with aub in testes) and negatively regulates Ste expression, most likely by cleaving its transcripts. Also in testis, may repress translation of vas when associated with a piRNA derived from chromosome X, termed AT-chX-1, whose sequence shows strong complementarity to vas mRNA. Aub-piRNA complexes from ovary and testis possess RNA cleavage activity. Involved in telomere regulation by repressing specialized telomeric retroelements HeT-A and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Also involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans, in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the suppression of meiotic drive of sex chromosomes and autosomes. Involved in transposon silencing in the adult brain. Required for dorsal-ventral as well as anterior-posterior patterning of the egg. Required during oogenesis for primordial germ cell formation and activation of RNA interference. During early oogenesis, required for osk mRNA silencing and polarization of the microtubule cytoskeleton. During mid-oogenesis, required for osk mRNA localization to the posterior pole and efficient translation of osk and grk. During embryogenesis, required for posterior localization of nanos (nos) mRNA, independently of osk, and pole cell formation. Essential for the formation and/or structural integrity of perinuclear nuage particles. Required for the localization of Mael to the meiotic nuage. Forms a complex with smg, twin, AGO3 and specific piRNAs that targets nanos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis. (UniProtKB:O76922)" FBgn0004872 UniProtKB "Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:15817569, PubMed:17346786, PubMed:26808625). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:16882972). In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner (PubMed:23159368, PubMed:28472469). Involved in silencing of long terminal repeat (LTR) retrotransposons in male germline (PubMed:15817569). In testis, regulates spermatogenesis together with Tudor-SN (PubMed:26808625). In germ cells, mediates silencing at both transcriptional and post-transcriptional levels and is involved in the maintenance of populations of primary and secondary piRNAs. Piwi-mediated transcriptional silencing is accompanied by the formation of His3 trimethylated on 'Lys-10' (H3K9me3) associated euchromatin and heterochromatin (PubMed:23392610, PubMed:23434410, PubMed:24906153). In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. Association with sense piRNAs is also observed but to a lesser extent. Mediates a somatic signaling mechanism required for the maintenance of germline stem cells to produce and maintain a daughter germline stem cell (PubMed:10631171, PubMed:16949822, PubMed:9199372, PubMed:9851978). It is not essential for the further differentiation of the committed daughter cell (PubMed:9851978). Acts cell autonomously to promote germline stem cell division (PubMed:10631171, PubMed:9851978). Its role in stem cell maintenance does not seem to require nuclear localization. Required maternally for the posterior localization of osk and vas and for pole cell formation during oogenesis and early embryogenesis (PubMed:16949822). Together with Hop and Hsp83, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation (PubMed:21186352). Shows RNA cleavage activity, although is not required for any of its known functions (PubMed:16882972, PubMed:23297219, PubMed:9199372). In the ovaries, forms a complex with nxf2, Panx and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31368590, PubMed:31384064). (UniProtKB:Q9VKM1)" FBgn0010612 FlyBase Gene Snapshot "ATP synthase, subunit G (ATPsynG) encodes a subunit in the F0 portion of mitochondrial ATP synthase (Complex V). ATP synthase catalyzes the formation of ATP using energy from a proton gradient across the inner mitochondrial membrane after electron transport." FBgn0000018 FlyBase Gene Snapshot abnormal oocyte (abo) encodes a negative regulator of histone transcription genes by its binding to their regulatory regions. abo mutations cause a maternal-effect lethality that can be rescued by specific regions of heterochromatin during early embryogenesis. FBgn0053129 Alliance "Involved in response to hyperoxia. Located in microvillus membrane. Is expressed in several structures, including adult head; adult heart; antennal primordium; gut section; and head epidermis primordium. Orthologous to human TMEM214 (transmembrane protein 214)." FBgn0032315 Alliance Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Is expressed in adult fat body. FBgn0032314 Alliance Predicted to enable citrate transmembrane transporter activity and succinate transmembrane transporter activity. Predicted to be involved in citrate transport; succinate transport; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0032313 Alliance Predicted to be located in membrane. FBgn0024227 FlyBase Gene Snapshot "aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis." FBgn0027453 Alliance "Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; anterior endoderm; brain; central nervous system; and embryonic/larval midgut primordium." FBgn0069354 FlyBase Gene Snapshot Porin2 (Porin2) encodes a protein with voltage-independent cation-selective pore activity that is involved in ion transport. FBgn0032305 Alliance Predicted to be active in nucleus. Orthologous to human LENG8 (leukocyte receptor cluster member 8). FBgn0051869 Alliance Predicted to enable BMP binding activity. Predicted to be involved in positive regulation of BMP signaling pathway. Predicted to be active in extracellular region. FBgn0032298 UniProtKB Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. (UniProtKB:Q9VKQ3) FBgn0032335 Alliance Is expressed in organism. FBgn0032338 Alliance Is expressed in adult head. FBgn0032339 UniProtKB "A component of the GATOR complex, which functions as a regulator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:36577058). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:36577058). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:23723238). Acts as an atypical component of the GATOR2 subcomplex, which can either promote or inhibit TORC1 signaling, depending on tissues: inhibits TORC1 activity by preventing the activity of GATOR2 in the ovary and the eye imaginal disk brain, while it promotes TORC1 activity in the fat body (PubMed:36577058). (UniProtKB:Q9VKK2)" FBgn0041246 UniProtKB "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females. (UniProtKB:Q9VKJ7)" FBgn0032348 UniProtKB Probable protease. (UniProtKB:Q9VKJ1) FBgn0040211 Alliance "Predicted to enable homogentisate 1,2-dioxygenase activity. Predicted to be involved in L-phenylalanine catabolic process. Is expressed in adult head; dorsal imaginal tissue; embryonic dorsal epidermis; and embryonic ventral epidermis. Human ortholog(s) of this gene implicated in alkaptonuria. Orthologous to human HGD (homogentisate 1,2-dioxygenase)." FBgn0032354 Alliance Part of pericentric heterochromatin. FBgn0032358 FlyBase Gene Snapshot Palmitoyl-protein Thioesterase 2 (Ppt2) encodes a lysosomal enzyme that removes palmitoyl groups form particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins. FBgn0020270 FlyBase Gene Snapshot meiotic recombination 11 (mre11) encodes a protein involved in the mitotic G2 DNA damage checkpoint and telomere capping. FBgn0040232 FlyBase Gene Snapshot CENP-meta (cmet) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment. FBgn0014076 FlyBase Gene Snapshot Vitelline membrane 32E (Vm32E) encodes a structural component of the vitelline membrane and the endochorion layer. FBgn0032350 Alliance Predicted to enable phosphoglycerate dehydrogenase activity. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). FBgn0010197 Alliance Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head; egg chamber; germarium; nurse cell; and organism. FBgn0028700 Alliance Predicted to enable ATP hydrolysis activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair; leading strand elongation; and sister chromatid cohesion. Part of Elg1 RFC-like complex. Orthologous to human RFC3 (replication factor C subunit 3). FBgn0032346 Alliance "Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of euchromatin and nuclear exosome (RNase complex). Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1F. Orthologous to human EXOSC1 (exosome component 1)." FBgn0032345 Alliance Involved in axonemal dynein complex assembly and sensory perception of sound. Part of R2TP complex. Is active in cytosol. Is expressed in Johnston organ; chordotonal neurons; dorsal sensory complex proper primordium; embryonic/larval oenocyte; and spermatogonium. Used to study sensorineural hearing loss. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). FBgn0027582 Alliance Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type ion transporter activity; and membrane protein dislocase activity. Predicted to be involved in extraction of mislocalized protein from ER membrane; intracellular calcium ion homeostasis; and transmembrane transport. Located in endomembrane system. Is expressed in adult head and spermatozoon. Orthologous to human ATP13A1 (ATPase 13A1). FBgn0032343 UniProtKB "Essential lysosomal hydrolase responsible for the degradation of the glycosaminoglycans (GAG) heparan sulfate and dermatan sulfate (Probable). Required for lysosome function and autophagy (PubMed:35011691). Consequently, has an essential role in the development, maintenance and function of various cells, tissues, and organs, including the muscles and the central nervous system (CNS) (PubMed:35011691). (UniProtKB:Q9VKJ8)" FBgn0032341 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be active in cytoplasm and plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to several human genes including REPS1 (RALBP1 associated Eps domain containing 1). FBgn0032337 Alliance Predicted to enable hormone activity. FBgn0032336 FlyBase Gene Snapshot Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. FBgn0000287 FlyBase Gene Snapshot "spalt-related (salr) encodes a zinc finger transcriptional repressor that, together with the product of salm, mediates most dpp functions during development of the central part of the wing. It is repressed by the product of Ubx during haltere development." FBgn0003313 UniProtKB Likely to be involved in the establishment of the head. (UniProtKB:P21750) FBgn0032362 Alliance Predicted to enable Toll binding activity and growth factor activity. Predicted to be involved in central nervous system formation and innate immune response. Located in extracellular space. Is expressed in organism. FBgn0051706 Alliance Is expressed in spermatozoon. FBgn0028490 Alliance Is expressed in adult head; organism; yolk; and yolk nucleus. FBgn0032363 Interactive Fly MAGUK family scaffold protein - required for the maintenance of apical polarity of follicle epithelium during oogenesis FBgn0015400 Alliance "Predicted to be located in plasma membrane. Is expressed in several structures, including embryonic/larval peripheral nervous system; head; larval ventral nerve cord; presumptive embryonic/larval peripheral nervous system; and ventral midline of embryo." FBgn0032372 Alliance Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to be located in cytosol. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase). FBgn0032373 Alliance "Predicted to enable ATPase binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4)." FBgn0032374 Alliance Is expressed in organism. FBgn0032378 Interactive Fly "cyclin that interacts with the cyclin dependent kinase Eip63E - has essential functions during embryogenesis, larval development, and metamorphosis - regulates wnt signaling" FBgn0020309 FlyBase Gene Snapshot crooked legs (crol) encodes a zinc finger transcription factor induced by 20-hydroxyecdysone at the onset of metamorphosis. It regulates wg transcription and cell cycle progression in the wing. Its over-expression in the eye accelerates the cell cycle and de-represses silenced genes. FBgn0032377 Alliance "Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; head epidermis primordium; and mesoderm." FBgn0032376 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2) and ROM1 (retinal outer segment membrane protein 1). FBgn0032368 Alliance Predicted to enable protein-membrane adaptor activity. Involved in double-strand break repair via homologous recombination and spermatogenesis. Colocalizes with spindle microtubule. Is expressed in primary spermatocyte; primary spermatocyte cyst; secondary spermatocyte; spermatid; and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to human SUN5 (Sad1 and UNC84 domain containing 5) and SPAG4 (sperm associated antigen 4). FBgn0051704 Alliance Involved in sexual reproduction. Located in extracellular space. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). FBgn0032381 Alliance "Enables alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1)." FBgn0032382 Alliance "Enables alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1)." FBgn0026392 FlyBase Gene Snapshot Odorant receptor 33a (Or33a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0026391 FlyBase Gene Snapshot Odorant receptor 33b (Or33b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0026390 FlyBase Gene Snapshot Odorant receptor 33c (Or33c) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0005664 FlyBase Gene Snapshot "Crystallin (Crys) encodes a chitin binding protein involved in the formation of the peritrophic matrix, a chitinous layer lining the midgut." FBgn0032387 Alliance Predicted to enable protein-glucosylgalactosylhydroxylysine glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult heart. Orthologous to human PGGHG (protein-glucosylgalactosylhydroxylysine glucosidase). FBgn0032390 UniProtKB "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). dgt2 binds to microtubules in vitro (PubMed:19289792). (UniProtKB:Q9VKD6)" FBgn0051866 FlyBase Gene Snapshot transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex. FBgn0051865 FlyBase Gene Snapshot transcriptional Adaptor 1-1 (Ada1-1) encodes a subunit of the SAGA chromatin modifying complex. FBgn0032393 UniProtKB Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. (UniProtKB:Q9VKD3) FBgn0014019 FlyBase Gene Snapshot Rhodopsin 5 (Rh5) encodes a visual GPCR opsin that covalently binds the chromophore retinal. A photon of light stimulates the isomerization of retinal resulting in a conformational change in the product of Rh5 and signal activation. Its peak sensitivity is in the blue and it is expressed in a subclass of R8 photoreceptors. FBgn0010497 FlyBase Gene Snapshot Dietary and metabolic glutamate transporter (dmGlut) encodes a sodium-independent transmembrane glutamate transporter. It plays an essential role during early embryogenesis. It causes megamitochondria formation when it is overexpressed. FBgn0042126 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in plasma membrane. FBgn0032402 Alliance "Predicted to enable phosphoric diester hydrolase activity. Involved in endosome organization. Located in endosome membrane. Is expressed in several structures, including embryonic hindgut; embryonic large intestine; embryonic/larval garland cell; spermatozoon; and ventral midline of embryo. Orthologous to human PLCXD1 (phosphatidylinositol specific phospholipase C X domain containing 1)." FBgn0032404 Alliance "Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of cytosolic large ribosomal subunit. Is expressed in adult head and organism. Orthologous to human RPL7L1 (ribosomal protein L7 like 1)." FBgn0027505 UniProtKB "Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (PubMed:21338884, PubMed:32248620). As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (PubMed:21338884). Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (PubMed:32248620). The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (PubMed:21338884). At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (PubMed:21338884). Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (PubMed:21338884). The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity). Regulates autophagy as part of a Rab3GAP-Rab18 module (PubMed:32248620). Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I (PubMed:32248620). (UniProtKB:Q9VKB9)" FBgn0032401 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Ras protein signal transduction and imaginal disc-derived wing vein specification. Predicted to be active in nucleus. Is expressed in organism." FBgn0032400 Alliance "Predicted to be involved in negative regulation of cell cycle; negative regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including NUPR1 (nuclear protein 1, transcriptional regulator)." FBgn0032398 Alliance "Predicted to be involved in retrograde protein transport, ER to cytosol. Located in endomembrane system. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1)." FBgn0032397 FlyBase Gene Snapshot Translocase of outer membrane 70 (Tom70) encodes a mitochondrial protein that may act as a receptor of the TOM complex based on orthology. TOM complex is involved in protein import into mitochondria. The product of Tom70 modulates cell death induced by the expression of the mouse Bax protein. FBgn0032395 Alliance "Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Involved in positive regulation of mitotic cell cycle phase transition. Predicted to be located in cytosol and early endosome membrane. Used to study microcephaly. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81)." FBgn0032394 Alliance "Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic head epidermis; and gut section. Human ortholog(s) of this gene implicated in congenital myopathy. Orthologous to human HACD1 (3-hydroxyacyl-CoA dehydratase 1) and HACD2 (3-hydroxyacyl-CoA dehydratase 2)." FBgn0042125 Alliance Predicted to enable metal ion binding activity. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human NUP42 (nucleoporin 42). FBgn0042127 Alliance Predicted to enable metal ion binding activity. Orthologous to human NUP42 (nucleoporin 42). FBgn0000588 FlyBase Gene Snapshot "extra sexcombs (esc) encodes an essential component of Polycomb Repressive Complex 2 (PRC2), which antagonizes chromatin opening and can be targeted to silence developmental genes." FBgn0032407 Alliance "Predicted to enable peroxisome membrane targeting sequence binding activity. Involved in peroxisome organization. Located in cytosol and peroxisome. Is expressed in several structures, including adult head; embryonic cortex; germ band; posterior midgut primordium; and yolk. Used to study Zellweger syndrome and peroxisome biogenesis disorder 12A. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 12A. Orthologous to human PEX19 (peroxisomal biogenesis factor 19)." FBgn0028707 FlyBase Gene Snapshot "Methyltransferase 2 (Mt2) encodes a (cytosine-5) tRNA methyltransferase. The modification protects tRNAs against endonucleolytic cleavage and contributes to stress resistance, protein translation and small RNA-mediated gene regulation." FBgn0032409 FlyBase Gene Snapshot "Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization." FBgn0027081 Alliance "Predicted to enable aminoacyl-tRNA editing activity and threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; gland; gut section; and mesoderm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS1 (threonyl-tRNA synthetase 1)." FBgn0032414 Alliance Predicted to enable integrin binding activity. Predicted to be involved in epithelial tube morphogenesis. Predicted to be located in extracellular matrix. Predicted to be active in extracellular region. Is expressed in spermatozoon. FBgn0032416 FlyBase Gene Snapshot Gustatory receptor 33a (Gr33a) encodes a seven-transmembrane chemoreceptor that is expressed in gustatory receptor neurons. It mainly detects non-volatile repulsive compounds and is involved in sexual behavior. FBgn0051760 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1E. Orthologous to human GPR158 (G protein-coupled receptor 158) and GPR179 (G protein-coupled receptor 179). FBgn0051860 Alliance Predicted to enable zinc ion transmembrane transporter activity. Involved in detoxification of zinc ion and intracellular zinc ion homeostasis. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A3 (solute carrier family 30 member 3) and SLC30A8 (solute carrier family 30 member 8). FBgn0032421 UniProtKB "Required for septate junction assembly, possibly by organizing the preassembly and transport of septate junction proteins including dlg1/disks large 1 and Nrx-IV/Neurexin-IV (PubMed:20570942). Involved in paracellular barrier functions of trachea, hindgut and salivary gland mediated by epithelial cell septate junctions (PubMed:20570942). (UniProtKB:Q9VKA0)" FBgn0000114 FlyBase Gene Snapshot "bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization." FBgn0051759 Alliance "Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to human PDE12 (phosphodiesterase 12)." FBgn0032424 Alliance Predicted to enable ribokinase activity. Predicted to be involved in D-ribose metabolic process. Predicted to be active in cytosol. Orthologous to human RBKS (ribokinase). FBgn0032422 Alliance Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in adult head and adult heart. FBgn0032420 Alliance Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Located in cytosol. Is expressed in adult brain cell body rind and adult head. FBgn0032415 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be located in membrane. Orthologous to human RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). FBgn0015797 FlyBase Gene Snapshot "Rab6 (Rab6) encodes a member of the Rab family, which are small Ras-like GTPases involved in vesicle trafficking. The Rab6 product localizes on late Golgi, and regulates vesicle trafficking within Golgi, post-Golgi, and endosome to Golgi." FBgn0029137 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Located in Golgi apparatus. Is expressed in adult brain; adult central nervous system; embryonic/larval brain; and embryonic/larval central nervous system. FBgn0032408 UniProtKB May be required for ribosome biogenesis. (UniProtKB:Q9VKB4) FBgn0041195 FlyBase Gene Snapshot "Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception." FBgn0032428 UniProtKB "Component of the DZIP1-Fam92-Cby complex which promotes ciliogenesis in sensory neurons and spermatocytes by acting downstream of Cep290 to initiate early ciliary membrane formation and thus transition zone (TZ) assembly (PubMed:31821146). During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules (PubMed:31821146). Within the complex, required to recruit or stabilize Cby at the distal basal body of cilia to promote DZIP1-mediated early ciliary membrane formation and initiate TZ assembly (PubMed:31821146, PubMed:33370260). May also act with Dzip1 to restrict Cep290 localization to the proximal part of the TZ (PubMed:31821146). May also be involved in recruitment or stabilization of Mks1 at the TZ (PubMed:31821146). (UniProtKB:Q9VK91)" FBgn0032430 UniProtKB Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. (UniProtKB:Q9VK89) FBgn0020443 FlyBase Gene Snapshot eukaryotic translation release factor 3 (eRF3) encodes a GTP-binding protein important in the termination of protein translation. FBgn0032435 Alliance "Enables transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in lateral plasma membrane. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0032439 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be active in nucleus. FBgn0051858 Alliance Predicted to be active in endomembrane system and membrane. Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0032436 Alliance Predicted to enable ribosylpyrimidine nucleosidase activity. Predicted to be involved in pyrimidine nucleoside catabolic process. FBgn0032434 Alliance Predicted to enable ATPase activator activity. Predicted to be involved in regulation of cellular pH. Predicted to be part of proton-transporting V-type ATPase complex. Is expressed in adult head. FBgn0032433 Alliance Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Is expressed in adult head. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1) and SLCO3A1 (solute carrier organic anion transporter family member 3A1). FBgn0032431 Alliance "Is expressed in several structures, including embryonic head sensory system; sensory nervous system primordium; and spermatozoon. Orthologous to human CFAP276 (cilia and flagella associated protein 276)." FBgn0032429 Alliance "Predicted to enable transcription corepressor activity. Predicted to be involved in cellular heat acclimation. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryonic head epidermis; embryonic head sensory system; and sensory nervous system primordium. Orthologous to human HSBP1 (heat shock factor binding protein 1)." FBgn0004394 FlyBase Gene Snapshot "POU domain protein 2 (pdm2) encodes a transcription factor that plays multiple roles in neurogenesis, including acting as a temporal identity gene and a timing gene required for the termination of the Kr temporal identity window." FBgn0032445 Alliance Predicted to be active in nucleus. Orthologous to human PITHD1 (PITH domain containing 1). FBgn0032447 Alliance "Predicted to enable membrane curvature sensor activity; phospholipid binding activity; and protein kinase C binding activity. Involved in several processes, including cellular response to sucrose stimulus; positive regulation of developmental growth; and regulation of postsynapse organization. Located in neuronal cell body. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; cell body rind region; and ganglia. Orthologous to human PICK1 (protein interacting with PRKCA 1)." FBgn0032451 FlyBase Gene Snapshot spichthyin (spict) encodes a BMP signaling pathway regulator involved in synaptic growth regulation at neuromuscular junctions. FBgn0032453 Alliance "Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol. Is expressed in several structures, including adult head; adult heart; gut section; posterior endoderm; and posterior midgut primordium. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1)." FBgn0015399 FlyBase Gene Snapshot "kekkon 1 (kek1) encodes a transmembrane protein that acts in a negative feedback loop to modulate the activity of the product of Egfr in a number of tissues, including follicle cells and imaginal discs. It also plays a role in axonal outgrowth in the central nervous system." FBgn0032457 Alliance Predicted to enable glucuronosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in Golgi apparatus. Is expressed in organism. FBgn0032454 Alliance Is expressed in adult head and spermatozoon. FBgn0032450 Alliance Predicted to enable ATP hydrolysis activity. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human AFG2A (AFG2 AAA ATPase homolog A). FBgn0032449 Alliance "Predicted to enable vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; biotin-responsive basal ganglia disease; cleft lip; dextro-looped transposition of the great arteries; and megaloblastic anemia. Orthologous to several human genes including SLC19A1 (solute carrier family 19 member 1) and SLC19A2 (solute carrier family 19 member 2)." FBgn0032446 Alliance Involved in positive regulation of canonical Wnt signaling pathway. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 3; retinitis pigmentosa 81; and short-rib thoracic dysplasia 18 with polydactyly. Orthologous to human IFT43 (intraflagellar transport 43). FBgn0032444 Alliance "Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; gut section; and mesoderm. Used to study intrinsic cardiomyopathy. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4)." FBgn0032442 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). FBgn0040509 Alliance Predicted to enable adenylate cyclase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; organism; pre-elongation spermatid; and spermatocyte. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). FBgn0040510 Alliance Predicted to enable adenylate cyclase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; organism; pre-elongation spermatid; and spermatocyte. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). FBgn0040506 UniProtKB Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (UniProtKB:Q9VK50) FBgn0032464 Alliance "Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase complex. Is expressed in several structures, including adult head; anterior endoderm; ejaculatory bulb; ejaculatory duct; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A)." FBgn0021796 UniProtKB "Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Regulates growth during animal development by coupling growth factor signaling to nutrient availability (PubMed:11069888). Central regulators of autophagy (PubMed:18604198, PubMed:19225150). May be involved in atg1 phosphorylation (PubMed:19225150). May also be involved, directly or indirectly, in the control of neuronal function (PubMed:15454083). Phosphorylates S6K/p70S6K, in vitro (PubMed:11069888). May regulate the activity of S6K (PubMed:11069885). Overexpression inhibits growth and reduces cell size (PubMed:14505573). Affects the timing of neuronal cell differentiation (PubMed:15454083). Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation (PubMed:15454083). Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism (PubMed:14505573). As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR (PubMed:25920570). REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation (PubMed:25920570). When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function (PubMed:25920570). This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes (PubMed:25920570). In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Rag GTPases act as activators of TORC1 in response to amino acid signals (PubMed:18604198). (UniProtKB:Q9VK45)" FBgn0032470 UniProtKB "Required for polyglutamylation of axonemal tubulin in sensory cilia. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. (UniProtKB:Q9VK41)" FBgn0028965 Alliance Enables protein phosphatase 1 binding activity. Is expressed in head mesoderm; organism; and trunk mesoderm. FBgn0032467 Alliance Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; organism; and spermatozoon. Orthologous to human UBE4B (ubiquitination factor E4B). FBgn0032465 Alliance Involved in positive regulation of synapse pruning and spermatogenesis. Located in cis-Golgi network and endoplasmic reticulum exit site. Is expressed in adult head. Used to study azoospermia. Orthologous to several human genes including YIPF7 (Yip1 domain family member 7). FBgn0032471 Alliance "Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked. Predicted to be active in peroxisome. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase)." FBgn0028410 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be active in nucleus. FBgn0032473 FlyBase Gene Snapshot kumgang (kmg) encodes a protein that exhibits chromatin binding activity. It is involved in regulation of gene expression and spermatogenesis. FBgn0024291 FlyBase Gene Snapshot "Sirtuin 1 (Sirt1) encodes an NAD[+]-dependent deacetylase that functions during euchromatic and heterochromatic gene silencing. Sirt1 product contributes to many biological pathways including neuronal function, apoptosis, metabolism, and development." FBgn0032476 Alliance Predicted to enable phosphatidylinositol binding activity. Is expressed in organism. Orthologous to human SNX29 (sorting nexin 29). FBgn0032477 Alliance Predicted to enable UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in membrane. Is expressed in adult head and embryonic proventriculus. Used to study congenital disorder of glycosylation Ij. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). FBgn0032478 Alliance Involved in axoneme assembly. Predicted to be located in cytosol and nucleus. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and primary ciliary dyskinesia 24. Orthologous to human RSPH1 (radial spoke head component 1). FBgn0032480 FlyBase Gene Snapshot "ER degradation enhancer, mannosidase alpha-like 2 (Edem2) encodes a lectin involved in the degradation of proteins during endoplasmic reticulum (ER) stress, which is generated by the presence of unfolded proteins in the ER." FBgn0032482 Alliance "Predicted to enable ethanolamine-phosphate cytidylyltransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in adult head and outer photoreceptor cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 82. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine)." FBgn0004192 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in Cajal body." FBgn0032486 Alliance Predicted to enable translation release factor activity. Predicted to be involved in mitochondrial translational termination. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to several human genes including MTRF1L (mitochondrial translation release factor 1 like). FBgn0032488 Alliance Located in nucleus. Is expressed in adult brain cell body rind; adult optic lobe; and organism. Orthologous to human C19orf47 (chromosome 19 open reading frame 47). FBgn0032491 Alliance "Is expressed in several structures, including antennal anlage; antennal primordium; endoderm anlage; posterior ectoderm anlage; and yolk nucleus." FBgn0032492 FlyBase Gene Snapshot "Proteasome alpha6 subunit, Testis-specific (Prosalpha6T) encodes a testes-specific subunit of the 26S proteasome." FBgn0027586 Alliance Predicted to be active in extracellular space. Is expressed in adult head and organism. FBgn0032494 Alliance Predicted to be active in extracellular space. Is expressed in adult head. FBgn0003935 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0032495 Alliance Predicted to be active in extracellular space. Is expressed in adult head; embryonic hindgut; embryonic large intestine; embryonic/larval posterior spiracle; and epithelial tube. FBgn0051851 Alliance Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be part of NatB complex. FBgn0032499 FlyBase Gene Snapshot "UV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation." FBgn0051729 Alliance "Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Is expressed in adult head. Orthologous to several human genes including ATP9B (ATPase phospholipid transporting 9B (putative))." FBgn0032505 Alliance Is expressed in adult head. FBgn0032509 Alliance Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in cytosol and nucleus. Is expressed in adult head and organism. Orthologous to human GLRX3 (glutaredoxin 3). FBgn0051852 FlyBase Gene Snapshot Two A-associated protein of 42kDa (Tap42) encodes a phosphatase inhibitor involved in wing disc morphogenesis and the organization of the mitotic spindle. FBgn0051855 Alliance Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DDA1 (DET1 and DDB1 associated 1). FBgn0032513 Alliance "Predicted to enable lipid binding activity. Involved in inner mitochondrial membrane organization. Is active in mitochondrial membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Orthologous to human STARD7 (StAR related lipid transfer domain containing 7)." FBgn0025724 UniProtKB "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (UniProtKB:O62621)" FBgn0032514 Alliance "Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic epipharynx; embryonic/larval midgut primordium; and gut section. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5)." FBgn0032512 FlyBase Gene Snapshot B double prime 1 (Bdp1) encodes a transcription factor involved in snRNA gene transcription. FBgn0032511 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 24. Orthologous to human NDUFB9 (NADH:ubiquinone oxidoreductase subunit B9)." FBgn0022069 UniProtKB May be involved in the generation of 28S rRNA. (UniProtKB:Q9VJZ7) FBgn0032507 Alliance Predicted to be involved in proteolysis. Is expressed in adult abdominal fat mass; adult brain; and adult fat body. FBgn0032506 Alliance Predicted to enable UDP-galactosyltransferase activity. Predicted to be involved in N-glycan processing and glycosylation. Predicted to be active in cytoplasm. Is expressed in embryonic antennal sense organ; embryonic brain; and larval ventral nerve cord. FBgn0028406 FlyBase Gene Snapshot "DNA fragmentation factor-related protein 4 (Drep4) encodes a CIDE domain containing protein that can interact with the proteins encoded by Drep3 and Drep1 via CIDE-CIDE interaction. It is the ortholog of human DFFB, which has a nuclease activity. The Drep4 product might function in apoptotic DNA fragmentation." FBgn0051730 Alliance Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be part of NatB complex. FBgn0032493 UniProtKB Plays a role in inducing apoptosis and is involved in the repair of head patterning defects in the embryo caused by extra maternal copies of the homeotic gene bicoid. (UniProtKB:Q9VK13) FBgn0032489 Alliance "Is expressed in several structures, including central brain primordium; dorsal ectoderm; midline primordium; ventral ectoderm; and ventral epidermis primordium." FBgn0032487 FlyBase Gene Snapshot Ski6 (Ski6) encodes a protein involved in gene expression regulation. FBgn0032485 Alliance Predicted to enable actin binding activity. Is expressed in embryonic/larval muscle system; embryonic/larval somatic muscle cell; and organism. Orthologous to human IPP (intracisternal A particle-promoted polypeptide). FBgn0032484 Alliance Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1) and LINGO2 (leucine rich repeat and Ig domain containing 2). FBgn0004191 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in Cajal body." FBgn0032481 Alliance Is expressed in adult head. FBgn0032479 Alliance Is expressed in adult head; embryonic myoblast; and organism. FBgn0051849 Alliance "Predicted to enable glycosyltransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process. Predicted to be located in membrane. Is expressed in organism. Orthologous to human MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase)." FBgn0032475 FlyBase Gene Snapshot Scm-related gene containing four mbt domains (Sfmbt) encodes a subunit of the Polycomb Group protein complex Pho repressive complex (PhoRC). This chromatin binding protein recognizes with high selectivity mono- and dimethylated lysine residues in various histone peptides. FBgn0032474 Alliance "Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval garland cell; embryonic/larval salivary gland; and larval ventral nerve cord." FBgn0032472 Alliance Is expressed in adult hemolymph. FBgn0032517 Alliance Predicted to enable DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Predicted to be part of transcription factor TFIIIC complex. Is expressed in spermatozoon. Orthologous to human GTF3C1 (general transcription factor IIIC subunit 1). FBgn0032522 Alliance Predicted to enable FMN adenylyltransferase activity. Predicted to be involved in FAD biosynthetic process. Predicted to be active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). FBgn0026760 FlyBase Gene Snapshot Tehao (Tehao) encodes a homologue of the receptor encoded by Tl. It is involved in the Toll signaling pathway and innate immune response. FBgn0028546 FlyBase Gene Snapshot "icarus (ics) encodes RSU1 (Ras suppressor 1), an adapter protein that participates in integrin-dependent processes by interacting with the integrin effector protein encoded by stck." FBgn0028513 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0023407 FlyBase Gene Snapshot B4 (B4) encodes a protein involved in imaginal disc development. FBgn0032530 Alliance Is expressed in spermatozoon. FBgn0032525 FlyBase Gene Snapshot Heat shock protein 60D (Hsp60D) encodes a protein involved in caspase-mediated apoptosis and polyQ-mediated neurodegeneration. FBgn0032524 Alliance "Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to several human genes including HACD3 (3-hydroxyacyl-CoA dehydratase 3)." FBgn0032523 Alliance Is expressed in border follicle cell. FBgn0003983 UniProtKB Major early eggshell protein. (UniProtKB:Q06521) FBgn0032520 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be part of outer dynein arm. Is expressed in adult head and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). FBgn0032519 Alliance Predicted to enable heme binding activity. Predicted to be located in endosome. Predicted to be active in endoplasmic reticulum and membrane. FBgn0032518 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPL24 (ribosomal protein L24). FBgn0032516 FlyBase Gene Snapshot "Inhibitor of growth family member 5 (Ing5) encodes a histone acetyltransferase that forms part of the Enok complex, which interacts with the product of elg1 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading." FBgn0028527 Alliance "Is expressed in several structures, including adult head; dorsal epidermis primordium; epithelium; gland; and gut section. Orthologous to human TMEM268 (transmembrane protein 268)." FBgn0028848 Alliance Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase (FAD) complex. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). FBgn0051813 UniProtKB Antimicrobial protein which is essential for the homeostatic regulation of sleep. Promotes sleep following sleep deprivation or bacterial infection and increases survival following bacterial infection. Likely to promote survival to bacterial infection in two ways; by contributing to the innate immune response and by promoting sleep during sickness to aid recovery. (UniProtKB:Q8IP68) FBgn0028541 FlyBase Gene Snapshot Transmembrane 9 superfamily protein member 4 (TM9SF4) encodes a nonaspanin-type protein involved in cellular immunity. FBgn0024846 FlyBase Gene Snapshot "p38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation." FBgn0028539 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Located in plasma membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0028931 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZBED1 (zinc finger BED-type containing 1). FBgn0028538 Alliance Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in Golgi to plasma membrane protein transport; positive regulation of endocytosis; and positive regulation of neuron remodeling. Located in trans-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). FBgn0027844 FlyBase Gene Snapshot Carbonic anhydrase 1 (CAH1) encodes an alpha-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons. FBgn0028919 UniProtKB "Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). (UniProtKB:Q9V412)" FBgn0001965 UniProtKB Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (UniProtKB:P26675) FBgn0015271 UniProtKB "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (UniProtKB:Q24169)" FBgn0026373 Alliance "Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase II activity. Involved in cellular response to heat. Located in cytoplasm; nucleus; and polytene chromosome puff. Part of RNA polymerase II, core complex. Is expressed in adult head and organism. Orthologous to human POLR2C (RNA polymerase II subunit C)." FBgn0028509 FlyBase Gene Snapshot "Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent." FBgn0028534 Alliance Is expressed in organism. FBgn0028533 Alliance Is expressed in adult head. FBgn0012037 FlyBase Gene Snapshot "Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides." FBgn0032535 Alliance Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. FBgn0025115 Alliance Enables acylphosphatase activity. Orthologous to human ACYP1 (acylphosphatase 1). FBgn0028544 Alliance Predicted to enable chitin binding activity. Predicted to be a structural constituent of chitin-based cuticle. Involved in wing disc development. Predicted to be located in chitin-based extracellular matrix. Is expressed in adult head; dorsal-ventral compartment boundary of the wing disc; wing anterior compartment; and wing pouch. FBgn0028938 Alliance Enables chitin binding activity. A structural constituent of chitin-based cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in adult head; dorsal ectoderm anlage; and organism. FBgn0019890 FlyBase Gene Snapshot Smg5 (Smg5) encodes a protein involved in mRNA catabolism. FBgn0028920 Alliance Is expressed in adult head. FBgn0053306 Alliance Is expressed in adult head. FBgn0001961 FlyBase Gene Snapshot "Actin-related protein 2/3 complex, subunit 1 (Arpc1) encodes one of seven components of the highly conserved Arp2/3 complex. The Arp2/3 complex is required for many cellular and developmental processes requiring F-actin polymerization, including germline ring canal growth, embryonic cellularization, myoblast fusion, and endocytosis." FBgn0004406 FlyBase Gene Snapshot "DNA polymerase gamma subunit 1 (PolG1) encodes the catalytic subunit of mitocondrial DNA polymerase gamma, which is responsible for the replication and repair of the mitochondrial genome." FBgn0028658 UniProtKB Specifically deaminates adenosine-37 to inosine in tRNA-Ala. (UniProtKB:Q9V3R6) FBgn0028932 Alliance Predicted to enable phosphatase activity. Orthologous to human FRA10AC1 (FRA10A associated CGG repeat 1). FBgn0028847 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. FBgn0051814 Alliance Predicted to be involved in establishment of synaptic specificity at neuromuscular junction. Predicted to be located in neuron projection membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NEGR1 (neuronal growth regulator 1). FBgn0027929 Alliance Predicted to be located in extracellular region. Is expressed in embryonic/larval fat body and embryonic/larval muscle system. FBgn0028936 Alliance Predicted to be located in extracellular region. FBgn0028940 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V419) FBgn0028939 Alliance Predicted to be involved in phagocytosis. Predicted to be located in membrane. FBgn0027348 UniProtKB "Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10373116, PubMed:26893370, PubMed:29739804). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104). (UniProtKB:Q9V3S9)" FBgn0028875 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor alpha5 (nAChRalpha5) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel." FBgn0051769 Alliance Is expressed in adult head. FBgn0028526 Alliance Located in extracellular region. Is expressed in adult head; adult heart; and embryonic/larval hemolymph. FBgn0028872 Alliance Predicted to be active in extracellular space. Is expressed in adult head. Orthologous to human LRRTM2 (leucine rich repeat transmembrane neuronal 2). FBgn0001967 FlyBase Gene Snapshot Nimrod C3 (NimC3) encodes a member of the highly conserved Nimrod cluster. It is a transmembrane protein with a putative phagocytosis receptor function. FBgn0028909 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003255 FlyBase Gene Snapshot rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. FBgn0028430 Alliance Involved in innate immune response. Is expressed in embryonic/larval lymph gland; hemocyte; larval sessile hemocyte; and lymph gland derived hemocyte. FBgn0028542 Alliance Predicted to be located in extracellular region. FBgn0028543 Alliance Involved in mesoderm development. Predicted to be located in extracellular region. Is expressed in adult pars intercerebralis. FBgn0052971 Alliance Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Orthologous to human MED22 (mediator complex subunit 22). FBgn0028916 UniProtKB Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. (UniProtKB:Q7KT91) FBgn0028531 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in synaptic signaling. Predicted to be active in plasma membrane. FBgn0015791 FlyBase Gene Snapshot "Rab14 (Rab14) encodes a protein involved in phagocytosis, phagolysosome assembly and phagosome maturation." FBgn0001970 FlyBase Gene Snapshot Polypeptide N-acetylgalactosaminyltransferase 35A (Pgant35A) encodes a member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family. It catalyzes the transfer of a GalNAc sugar onto the hydroxyl groups of serine and threonine in secreted or membrane-bound proteins. The product of Pgant35A is an essential protein involved in epithelial tube polarity. FBgn0028844 Alliance Predicted to be involved in mitochondrial respiratory chain complex II assembly. Predicted to be active in mitochondrion. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4). FBgn0028871 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0004858 UniProtKB May negatively regulate Notch-induced cell proliferation in the eye-head primordium. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Required for tracheal development. (UniProtKB:Q9VJS8) FBgn0020258 FlyBase Gene Snapshot "pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis." FBgn0028530 FlyBase Gene Snapshot "mitochondrial transcription termination factor (mTTF) encodes a sequence-specific DNA binding protein that interacts with two regions of the mitochondrial genome, each located at the common 3' end of oppositely transcribed gene clusters. The mTTF product arrests transcription in the 'forward' direction, as well as acting as a replication fork barrier, which is believed to prevent collisions between the replication and transcription machineries. Its dimerization partner, encoded by mTerf5, antagonizes these activities." FBgn0005771 UniProtKB May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development. (UniProtKB:Q24423) FBgn0028882 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0028912 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0028910 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0028855 Alliance "Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; epithelium; and yolk nucleus." FBgn0028911 Alliance Predicted to enable CCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0028913 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in postreplication repair and protein K63-linked ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N) and UBE2NL (ubiquitin conjugating enzyme E2 N like (gene/pseudogene)). FBgn0011866 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011865 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011864 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011863 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051835 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in synaptic signaling. Predicted to be active in plasma membrane. FBgn0028870 Alliance Is expressed in spermatozoon. FBgn0028838 Alliance Predicted to be involved in protein deneddylation. Predicted to be part of COP9 signalosome. Orthologous to human GPS1 (G protein pathway suppressor 1). FBgn0028868 Alliance Predicted to enable membrane protein dislocase activity. Predicted to be involved in extraction of mislocalized protein from mitochondrial outer membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). FBgn0028887 Alliance Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to several human genes including SBNO1 (strawberry notch homolog 1). FBgn0013301 FlyBase Gene Snapshot Protamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. FBgn0013300 FlyBase Gene Snapshot Protamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. FBgn0032554 Alliance Is expressed in early elongation stage spermatid; primary spermatocyte; and secondary spermatocyte. FBgn0032553 Alliance Predicted to be active in membrane. Is expressed in adult head; early elongation stage spermatid; primary spermatocyte; and secondary spermatocyte. FBgn0028886 Alliance Predicted to enable L-amino acid transmembrane transporter activity; amino acid:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. FBgn0028866 Alliance Predicted to be involved in proteolysis. FBgn0032549 Alliance Predicted to be involved in proteolysis. FBgn0028537 Alliance Is expressed in amnioserosa; embryonic/larval fat body; and yolk nucleus. FBgn0040228 FlyBase Gene Snapshot "Dynactin 5, p25 subunit (DCTN5-p25) encodes a motor protein involved in spermatogenesis. It also contributes to the dendritic restriction of the product of Dscam1." FBgn0028926 UniProtKB "Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements (PubMed:11062130). Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes (PubMed:18327268). (UniProtKB:Q9VJQ5)" FBgn0260446 FlyBase Gene Snapshot metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. FBgn0053310 Alliance Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be part of sodium:potassium-exchanging ATPase complex. FBgn0041713 Alliance Predicted to be active in extracellular region. Is expressed in adult head. FBgn0004837 UniProtKB "Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:10673509, PubMed:1617729, PubMed:21262215, PubMed:8674407). Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:10673509). Acts as a transcriptional repressor when it is not associated with Notch proteins (PubMed:10673509). When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (PubMed:10673509). Required for transcription of Sim (PubMed:10673509). Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence (PubMed:1617729, PubMed:1617730, PubMed:1744127). Required for neurogenesis in imaginal disks (PubMed:1617730, PubMed:7813798). In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development (PubMed:21262215). Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell (PubMed:12642500). (UniProtKB:P28159)" FBgn0028879 Alliance Predicted to enable intracellularly calcium-gated chloride channel activity. Involved in detection of cold stimulus involved in thermoception and detection of temperature stimulus involved in sensory perception of pain. Predicted to be active in plasma membrane. Is expressed in adult head; central brain primordium; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium. Orthologous to human ANO8 (anoctamin 8). FBgn0028878 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anterior spiracle primordium; embryonic anal pad; embryonic/larval posterior spiracle; organism; and posterior spiracle primordium." FBgn0001978 FlyBase Gene Snapshot "shuttle craft (stc) encodes a zinc finger transcription factor of the NFX1 family. Maternally contributed protein is essential for segmentation. During the late stages of embryonic neurogenesis, zygotically expressed stc product is involved in axon guidance, which is vital for proper muscle innervation. stc expression in the embryo is important for the adult life span and aging." FBgn0028862 Alliance Located in plasma membrane. Is expressed in adult head; embryonic brain; and larval ventral nerve cord. FBgn0028516 FlyBase Gene Snapshot Zinc transporter 35C (ZnT35C) encodes a protein involved in cellular and organismal zinc efflux that plays a major role in the detoxification of zinc excess. ZnT35C is a target of the metal-responsive transcription factor encoded by MTF-1. FBgn0028888 Alliance Is expressed in adult head. Human ortholog(s) of this gene implicated in COVID-19; X-Linked immunodeficiency 74; and primary immunodeficiency disease. Orthologous to several human genes including NRROS (negative regulator of reactive oxygen species); TLR7 (toll like receptor 7); and TLR8 (toll like receptor 8). FBgn0028889 Alliance Predicted to enable UUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0024183 FlyBase Gene Snapshot vasa intronic gene (vig) encodes a protein involved in RNA interference and heterochromatin organization. FBgn0010422 UniProtKB "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. (UniProtKB:P20232)" FBgn0000317 FlyBase Gene Snapshot crinkled (ck) encodes a myosin VIIa homolog that is expected to have roles in cellular protrusion formation and cargo intracellular transport. ck hypomorphs are hearing defective and present abnormal chaetae and trichomes. FBgn0001977 FlyBase Gene Snapshot "Cytokine induced apoptosis inhibitor 1 (CIAPIN1) encodes a protein required for chamber development, follicle cell proliferation and survival." FBgn0051832 Alliance Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human MFAP4 (microfibril associated protein 4). FBgn0011239 Alliance Involved in spermatid differentiation. FBgn0028852 Alliance Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening and regulation of stem cell population maintenance. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). FBgn0028892 Alliance Predicted to enable phosphatase activity. Predicted to be involved in DNA damage response. Orthologous to human ARMT1 (acidic residue methyltransferase 1). FBgn0003448 FlyBase Gene Snapshot "snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division." FBgn0001983 FlyBase Gene Snapshot worniu (wor) encodes a zinc finger C2H2 transcription factor involved in nervous system development. It contributes to neuroblast asymmetric cell division and brain development. FBgn0032563 Alliance "Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and ventral nerve cord primordium." FBgn0041103 FlyBase Gene Snapshot no hitter (nht) encodes a testis binding protein associated factor involved in tissue-specific transcription regulation and spermatogenesis. FBgn0028370 Alliance Predicted to be located in plasma membrane. Orthologous to human LRFN1 (leucine rich repeat and fibronectin type III domain containing 1). FBgn0028947 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. FBgn0028945 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. FBgn0028864 Alliance Predicted to be involved in proteolysis. FBgn0028517 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0051780 Alliance Predicted to be involved in proteolysis. FBgn0051827 Alliance Predicted to be involved in proteolysis. FBgn0001986 FlyBase Gene Snapshot Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response. FBgn0028507 Alliance Predicted to enable protein C-terminal leucine carboxyl O-methyltransferase activity. Predicted to be involved in methylation. Predicted to be active in cytosol. Is expressed in adult head and organism. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). FBgn0051826 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. FBgn0041627 FlyBase Gene Snapshot "Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair." FBgn0001990 FlyBase Gene Snapshot "weckle (wek) encodes a zinc finger adaptor protein of the Toll signaling pathway in embryonic dorsoventral patterning. It facilitates the recruitment of the product of Myd88 to the receptor encoded by Tl. However, the product of wek is dispensable for Toll-mediated innate immunue response." FBgn0001987 FlyBase Gene Snapshot Gliotactin (Gli) encodes a transmembrane protein localized at tricellular junctions that is necessary for septate junction and permeability barrier formation. FBgn0003936 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0001989 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon." FBgn0028863 Alliance Predicted to enable voltage-gated calcium channel activity. Involved in regulation of dendrite development. Predicted to be part of voltage-gated calcium channel complex. Is expressed in adult head and spermatozoon. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). FBgn0028946 FlyBase Gene Snapshot Odorant receptor 35a (Or35a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0028948 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). FBgn0028949 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). FBgn0028944 FlyBase Gene Snapshot "Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female." FBgn0028950 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). FBgn0028901 Alliance Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in centriole and mitochondrial outer membrane. FBgn0028903 Alliance Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 54. Orthologous to human CATIP (ciliogenesis associated TTC17 interacting protein). FBgn0028902 Alliance "Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Predicted to be active in microtubule cytoskeleton. Is expressed in several structures, including adult head; chordotonal organ precursor cell; embryonic head sensory system; male germline cell; and sensory nervous system primordium. Orthologous to human TEKT4 (tektin 4)." FBgn0028514 Alliance Involved in positive regulation of hemocyte proliferation. Predicted to be active in extracellular space. FBgn0028856 Alliance Orthologous to human SPATA17 (spermatogenesis associated 17). FBgn0028858 Alliance Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Is expressed in spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). FBgn0028644 FlyBase Gene Snapshot beaten path Ic (beat-Ic) encodes a protein involved in axon guidance. FBgn0045827 Alliance Is expressed in testis. FBgn0000182 FlyBase Gene Snapshot Bicaudal C (BicC) encodes an RNA binding protein that interacts with the deadenylase encoded by twin and negatively regulates target mRNAs. It is required for oogenesis and is a maternally-expressed gene involved in embryonic patterning. FBgn0013433 FlyBase Gene Snapshot "beaten path Ia (beat-Ia) encodes a transmembrane protein and the founding member of the beat family of proteins, which is part of the immunoglobulin superfamily. It is required for the selective defasciculation of motor axons." FBgn0028645 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and motor neuron axon guidance. Predicted to be located in plasma membrane. FBgn0051821 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human SCPEP1 (serine carboxypeptidase 1). FBgn0051823 Alliance Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head and embryonic/larval midgut. Orthologous to human SCPEP1 (serine carboxypeptidase 1). FBgn0041183 Alliance Predicted to enable endopeptidase inhibitor activity. Involved in innate immune response. Predicted to be located in extracellular space. Is expressed in adult proventriculus; embryonic/larval fat body; embryonic/larval lymph gland; embryonic/larval plasmatocyte; and embryonic/larval proventriculus. Orthologous to human CD109 (CD109 molecule). FBgn0028935 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human LVRN (laeverin). FBgn0028884 Alliance Predicted to be active in cytoplasm. FBgn0028515 FlyBase Gene Snapshot "Endonuclease G inhibitor (EndoGI) encodes an inhibitor of the enzyme encoded by EndoG by tight binding to the enzymatic active site. Since the product of EndoG is mostly or entirely localized in mitochondria, the product of EndoGI has been suggested to protect cells against mis-localization of the enzyme." FBgn0028897 Alliance "Predicted to enable molecular adaptor activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human WDR83 (WD repeat domain 83)." FBgn0040079 Alliance Predicted to enable protein kinase A binding activity. Predicted to be involved in protein localization. Predicted to be active in mitochondrion and plasma membrane. Orthologous to human AKAP10 (A-kinase anchoring protein 10). FBgn0028896 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. FBgn0001992 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V399) FBgn0028895 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm." FBgn0028525 FlyBase Gene Snapshot "crossover suppressor on 2 of Manheim (c(2)M) encodes a Kleisin family member in the cohesin proteins. It interacts with cohesins, such as the products of SMC1 and SMC3, to promote synaptonemal complex assembly in female meiosis." FBgn0011708 FlyBase Gene Snapshot Syntaxin 5 (Syx5) encodes a type II transmembrane protein in the Q-SNARE family that forms hetero tetramers required for membrane function in the early secretory pathway (ER and Golgi). It has been involved in cytokinesis during spermatogenesis. FBgn0001086 FlyBase Gene Snapshot fizzy (fzy) encodes WD40 domain protein required for the full ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) in mitosis and meiosis. The product of fzy functions to target substrates for destruction and drive metaphase and anaphase transition. FBgn0014092 Alliance Predicted to be active in mitochondrion. Is expressed in adult heart and organism. Orthologous to human NIF3L1 (NGG1 interacting factor 3 like 1). FBgn0040984 Alliance "Is expressed in several structures, including clypeo-labral primordium; dorsal ectoderm; dorsal epidermis primordium; embryonic dorsal epidermis; and ganglia." FBgn0028506 Alliance "Is expressed in several structures, including Malpighian tubule primordium; antennal primordium; central brain primordium; embryonic/larval midgut primordium; and head epidermis primordium." FBgn0025678 FlyBase Gene Snapshot calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. FBgn0000307 FlyBase Gene Snapshot "chiffon (chif) encodes a protein associated with the origin recognition complex that binds to chromosomal origins of replication and is required for the initiation of cellular DNA replication. It is involved in DNA replication, chorion production, muscle homeostasis, and axon guidance." FBgn0028899 Alliance Is expressed in spermatozoon. FBgn0001995 Alliance Predicted to be a structural constituent of ribosome. Involved in positive regulation of Notch signaling pathway. Is active in nucleus. Is expressed in adult head. Orthologous to human MRPL4 (mitochondrial ribosomal protein L4). FBgn0000250 FlyBase Gene Snapshot "cactus (cact) encodes the homolog of mammalian IkappaB. cact product acts as an inhibitor of NF-kappaB signaling by binding to the products of dl and Dif, which prevents their nuclear translocation. Toll signaling promotes the destruction of cact protein, which allows the products of dl and Dif to enter the nucleus and regulate gene expression." FBgn0000339 UniProtKB "Acts as a cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo. (UniProtKB:P49858)" FBgn0015338 FlyBase Gene Snapshot CG5861 encodes a transmembrane protein involved in phagocytosis. FBgn0028894 FlyBase Gene Snapshot "Glia maturation factor (GMF) encodes a protein belonging to the ADF-H domain family of proteins, which promote dissambly of actin networks. It specifically binds to and promotes disassembly of Arp2/3-nucleated lamellipodial actin networks. It plays a role in promoting protrusion dynamics during cell migration." FBgn0028375 FlyBase Gene Snapshot "heixuedian (heix) encodes a protein belonging to the UbiA prenyltransferase family that participates in the regulation of cholesterol. It is involved in signal transduction pathways such as JAK/STAT, Ras/MAPK, Toll, IMD, and Notch. It contributes to growth regulation, cell differentiation and apoptosis, antioxidation and neurodegeneration." FBgn0001994 FlyBase Gene Snapshot "cropped (crp) encodes a transcription factor that controls cellular branching of the terminal cells at the ends of tracheal tubes. As a downstream target gene of the product of Myc, it affects cell growth, organ size and survival." FBgn0002673 FlyBase Gene Snapshot twine (twe) encodes a putative tyrosine phosphatase. It regulates the meiotic cell cycle and contributes to spermatogenesis. FBgn0024734 FlyBase Gene Snapshot PRL-1 phosphatase (PRL-1) encodes a growth inhibitor that counteracts the function of the product of the Src42A oncogene. FBgn0020416 FlyBase Gene Snapshot Imaginal disc growth factor 1 (Idgf1) encodes a member of the chitinase-like protein family. Idgf1 is expressed in the ectodermally-derived cuticle forming organs and its product is required for the formation of the chitinous apical extracellular matrix during larval development. FBgn0020415 FlyBase Gene Snapshot Imaginal disc growth factor 2 (Idgf2) encodes a secreted glycoprotein that is a member of the chitinase-like protein family mainly expressed in fat body and hemocytes. Idgf2 product is induced under stress conditions. FBgn0020414 FlyBase Gene Snapshot "Imaginal disc growth factor 3 (Idgf3) encodes a member of the chitinase-like protein family that was originally shown to facilitate insulin signalling in imaginal disc cell lines. Idgf3 product is a component of hemolymph clot, aids in wound healing and protects against certain infections." FBgn0032585 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0032586 Alliance Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in adult head. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). FBgn0051816 Alliance Is expressed in spermatozoon. FBgn0032587 Alliance Is expressed in organism. FBgn0028523 Alliance "Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including central brain primordium; dorsal ectoderm anlage; embryonic optic lobe primordium; hindgut anlage; and hindgut anlage in statu nascendi. Orthologous to human LRRC26 (leucine rich repeat containing 26) and LRRC52 (leucine rich repeat containing 52)." FBgn0001185 FlyBase Gene Snapshot hermaphrodite (her) encodes a zinc finger C2H2 transcription factor involved in sex determination and differentiation. FBgn0051812 Alliance Predicted to enable tRNA-intron endonuclease activity. Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). FBgn0032597 UniProtKB "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The Nubp1-Nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. (UniProtKB:Q9VJI9)" FBgn0032598 Alliance "Predicted to enable chitin deacetylase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0032600 FlyBase Gene Snapshot Bub3 interacting GLEBS and Zinc finger domain protein (BuGZ) encodes a protein involved in dendrite morphogenesis. FBgn0032601 FlyBase Gene Snapshot "yellow-b (yellow-b) is a member of the multifunctional yellow family of genes that encodes a protein involved in color pattering, eggshell integrity and mating behavior." FBgn0032603 Alliance Predicted to enable oxidoreductase activity. Predicted to be involved in lipid metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. FBgn0040262 Alliance Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Orthologous to several human genes including UGT1A3 (UDP glucuronosyltransferase family 1 member A3); UGT1A4 (UDP glucuronosyltransferase family 1 member A4); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). FBgn0040261 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0040260 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in several structures, including adult head; anterior endoderm; crystal cell primordium; embryonic/larval midgut primordium; and embryonic/larval somatic muscle cell. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0004797 FlyBase Gene Snapshot midway (mdy) encodes an acyl coenzyme A: diacylglycerol acyltransferase that functions in the formation of triglycerides. Lack of mdy leads to female sterility and impaired fat metabolism in larvae and adults. FBgn0051739 FlyBase Gene Snapshot "Aspartyl-tRNA synthetase, mitochondrial (AspRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of aspartate to its cognate tRNA to form aspartyl-tRNA." FBgn0051781 Alliance Involved in lateral inhibition. Is expressed in embryonic/larval somatic muscle cell. FBgn0032615 Alliance Predicted to enable oxidoreductase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1). FBgn0051809 Alliance "Predicted to enable oxidoreductase activity. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and gland. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1)." FBgn0051810 Alliance "Predicted to enable oxidoreductase activity. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult fat body; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and gland. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1)." FBgn0032614 Alliance "Predicted to enable oxidoreductase activity. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; embryonic large intestine; and gut section. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1)." FBgn0032613 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. FBgn0032612 Alliance "Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0022213 UniProtKB Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). (UniProtKB:Q9XZU1) FBgn0032609 Alliance Predicted to enable D-xylose 1-dehydrogenase (NADP+) activity. Predicted to be involved in D-xylose catabolic process. Orthologous to human DHDH (dihydrodiol dehydrogenase). FBgn0032602 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0015391 FlyBase Gene Snapshot gluon (glu) encodes a subunit of the multiprotein complex condensin that is required for chromosome condensation and sister chromatid segregation. It contributes to nervous system development and glucose metabolism. FBgn0032596 FlyBase Gene Snapshot Proteasome beta4 subunit (Prosbeta4) encodes a protein involved in proteasomal degradation. FBgn0032595 Alliance Predicted to enable copper ion binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Orthologous to human CMC1 (C-X9-C motif containing 1). FBgn0027779 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). (UniProtKB:Q9V3J1)" FBgn0062978 Alliance "Is expressed in several structures, including Malpighian tubule primordium; embryonic epipharynx; embryonic/larval circulatory system; epithelium; and gut section." FBgn0051807 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. FBgn0032593 UniProtKB A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl. (UniProtKB:Q9VJJ7) FBgn0032618 Alliance Predicted to enable chondroitin 4-sulfotransferase activity. Predicted to be involved in carbohydrate biosynthetic process. Predicted to be located in membrane. Orthologous to several human genes including CHST11 (carbohydrate sulfotransferase 11). FBgn0053179 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and motor neuron axon guidance. FBgn0032625 Alliance Is expressed in adult head. FBgn0026150 UniProtKB "Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. (UniProtKB:Q9VJG0)" FBgn0032620 Alliance "Predicted to enable mRNA binding activity and rRNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human RBM34 (RNA binding motif protein 34)." FBgn0051805 Alliance Involved in wound healing. Is expressed in spermatozoon. FBgn0040985 Alliance Involved in negative regulation of cellular respiration. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human ETFRF1 (electron transfer flavoprotein regulatory factor 1). FBgn0052832 Alliance Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and spermatozoon. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). FBgn0045487 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58955)" FBgn0045486 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9VJF2)" FBgn0045485 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8INZ2)" FBgn0046888 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0032633 FlyBase Gene Snapshot Leucine-rich-repeats and calponin homology domain protein (Lrch) encodes a scaffold protein well conserved across animals that associates with actin-rich structures during cell division. Lack of Lrch results in a reduction of fertility and fitness. FBgn0032632 Alliance Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in regulation of signal transduction. Orthologous to several human genes including PPP1R2B (PPP1R2 family member B); PPP1R2C (PPP1R2C family member C); and PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). FBgn0032629 Alliance "Involved in motor neuron axon guidance and synaptic target inhibition. Is expressed in several structures, including apoptotic amnioserosa; embryonic/larval midgut primordium; ganglia; mesoderm; and visceral mesoderm derivative." FBgn0020503 UniProtKB Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization. (UniProtKB:Q9VJE5) FBgn0032635 Alliance "Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval nervous system; ganglia; and somatic precursor cell. Orthologous to human UBR7 (ubiquitin protein ligase E3 component n-recognin 7)." FBgn0032636 Alliance Is expressed in adult head. FBgn0032640 FlyBase Gene Snapshot small glutamine-rich tetratricopeptide containing protein (Sgt) encodes a protein involved in the regulation of the protein folding mediated by chaperones. FBgn0032642 FlyBase Gene Snapshot "Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (Lamtor3) encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae." FBgn0032644 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Is expressed in adult head; adult heart; and organism. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog). FBgn0013810 FlyBase Gene Snapshot Dynein heavy chain at 36C (Dhc36C) encodes a motor protein involved in hearing. FBgn0032651 Interactive Fly HLH transcription factor expressed in the brain and CNS - motor neuron identify factor - regulates axon guidance FBgn0032654 Alliance Predicted to be active in Golgi apparatus. Is expressed in organism. Orthologous to human SELENOH (selenoprotein H). FBgn0032652 Alliance Predicted to enable heme binding activity. Predicted to be involved in sterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle and membrane. Is expressed in amnioserosa; embryonic/larval fat body; eye; fat body/gonad primordium; and yolk nucleus. FBgn0032650 Alliance Enables protein serine/threonine kinase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and signal transduction. Located in cytoplasm. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). FBgn0032649 Alliance Is expressed in spermatogonium. Human ortholog(s) of this gene implicated in spermatogenic failure 51. Orthologous to human CFAP91 (cilia and flagella associated protein 91). FBgn0032648 Alliance Is expressed in spermatogonium and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 51. Orthologous to human CFAP91 (cilia and flagella associated protein 91). FBgn0032647 Alliance Is expressed in spermatogonium. Human ortholog(s) of this gene implicated in spermatogenic failure 51. Orthologous to human CFAP91 (cilia and flagella associated protein 91). FBgn0032646 FlyBase Gene Snapshot mitochondrial translation elongation factor Ts (mEFTs) encodes a protein predicted to function within mitochondria to recharge the products of mEFTu1 and mEFTu2 with GTP during the elongation phase of mRNA translation. FBgn0032645 Alliance Predicted to be active in cytoplasm and nucleus. FBgn0003187 FlyBase Gene Snapshot quail (qua) encodes a member of the Villin family of F-actin crosslinking proteins. It is involved in wing hair growth and oogenesis. FBgn0032643 Alliance Predicted to be involved in N-glycan processing. Located in endomembrane system. Is expressed in adult head; adult heart; embryonic proventriculus; and organism. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (PRKCSH beta subunit of glucosidase II). FBgn0024689 FlyBase Gene Snapshot "four way stop (fws) encodes a protein localised to the Golgi apparatus and involved in several aspects of spermatogenesis. Loss of function of fws causes failure of cleavage furrow ingression in dividing spermatocytes, as well as failure of cell elongation and disruption of the Golgi-based acroblast during spermatid differentiation" FBgn0000183 FlyBase Gene Snapshot "Bicaudal D (BicD) encodes a cytoplasmic protein that links diverse cargo to the dynein/dynactin motor. Cargos like mRNAs, proteins and organelles are transported along microtubules. Through this mechanism the product of BicDcontrols spatial aspects of gene expression and polarity formation during development. Additionally, it supports physiology of differentiated polar cells and the function of the nervous system." FBgn0032639 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0032638 Alliance Involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular space. FBgn0011274 FlyBase Gene Snapshot "Dorsal-related immunity factor (Dif) encodes a transcription factor that contributes to zygotic function of the Toll pathway, notably the regulation of antimicrobial peptides, but it is not involved in dorsoventral patterning of the embryo." FBgn0051803 Alliance Involved in axoneme assembly. Predicted to be active in axoneme. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 12. Orthologous to human RSPH9 (radial spoke head component 9). FBgn0032634 UniProtKB DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). (UniProtKB:Q9VJE4) FBgn0032656 Alliance Is expressed in organism. FBgn0051742 Alliance "Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including PSMB5 (proteasome 20S subunit beta 5)." FBgn0000120 FlyBase Gene Snapshot Arrestin 1 (Arr1) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell perception. FBgn0002939 FlyBase Gene Snapshot "neither inactivation nor afterpotential D (ninaD) encodes a scavenger receptor involved in carotenoid transport, light detection and rhodopsin biosynthesis." FBgn0051741 Alliance Predicted to enable scavenger receptor activity. Involved in defense response to protozoan. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in embryonic/larval garland cell; embryonic/larval midgut; and embryonic/larval salivary gland. Orthologous to human SCARB1 (scavenger receptor class B member 1). FBgn0032664 Alliance Predicted to be involved in mitochondrial fission. Located in mitochondrial membrane and plasma membrane. Is expressed in adult head. Used to study neuropathy. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1E. Orthologous to human SLC25A46 (solute carrier family 25 member 46). FBgn0041184 FlyBase Gene Snapshot Suppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. FBgn0051785 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0032660 FlyBase Gene Snapshot "elfless (elfless) encodes a RING-finger E3 ubiquitin ligase expressed in the tail cyst cell nuclei of testes, although it is not required for male fertility. It interacts with the apoptosis pathway (with the products of Dronc, eff, Diap1) and may be involved in tail cyst cell degradation." FBgn0023096 FlyBase Gene Snapshot "beethoven (btv) encodes the minor cytoplasmic dynein heavy chain, which is the retrograde motor for intraflagellar transport. It is required for the proper assembly of the sensory cilia in chordotonal organs. It contributes to hearing and other chordotonal-dependent functions such as larval locomotion." FBgn0032669 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0032670 Alliance Predicted to enable glycine N-acyltransferase activity. FBgn0032677 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Part of Dbf4-dependent protein kinase complex. Orthologous to human CDC7 (cell division cycle 7). FBgn0000636 FlyBase Gene Snapshot Fasciclin 3 (Fas3) encodes a cell adhesion molecule expressed by subsets of motoneurons and muscle cells in the embryonic/larval motor system. FBgn0011559 FlyBase Gene Snapshot Accessory gland protein 36DE (Acp36DE) encodes a glycoprotein produced in male accessory glands and transferred to females during mating. It causes changes in female uterine conformation that assists with the movement of sperm into storage. It influences sperm competition outcomes including the likelihood of storage of a second male's sperm. FBgn0051787 Alliance "Predicted to enable cargo receptor activity. Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult head. Orthologous to human TMED1 (transmembrane p24 trafficking protein 1) and TMED5 (transmembrane p24 trafficking protein 5)." FBgn0051802 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in centriole replication. Predicted to be active in centriole; centrosome; and nucleus. Orthologous to human CETN1 (centrin 1). FBgn0032671 Alliance Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of translational termination. Located in cytoplasm. Is expressed in organism. Orthologous to human JMJD4 (jumonji domain containing 4). FBgn0032680 Alliance Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be part of nuclear pore central transport channel. Is expressed in testis. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). FBgn0032682 FlyBase Gene Snapshot "grindelwald (grnd) encodes a receptor of the TNF superfamily ligand encoded by egr, which activates the intracellular JNK pathway. It is involved in apoptosis and neoplastic growth." FBgn0032684 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0032685 Alliance "Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section." FBgn0032688 Alliance Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be part of chromatin. Is expressed in organism. Orthologous to human RPRD2 (regulation of nuclear pre-mRNA domain containing 2). FBgn0032690 Alliance Predicted to enable mRNA binding activity. Involved in regulation of defense response to virus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head and spermatozoon. Orthologous to human DDX23 (DEAD-box helicase 23). FBgn0032694 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; endoderm anlage; head epidermis primordium; and mesoderm." FBgn0032693 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VJ71) FBgn0032692 Alliance "Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and motile cilium. Is expressed in several structures, including peripheral sensory precursor cell; sense organ; sensory cluster; sensory nervous system primordium; and sensory organ cell. Orthologous to human IFT46 (intraflagellar transport 46)." FBgn0032691 FlyBase Gene Snapshot "Ada2a-containing complex component 2 (Atac2) encodes a protein involved in chromatin organization, intestinal stem cell homeostasis, and histone acetylation." FBgn0032689 Alliance "Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; chloride transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; circulatory system primordium; epithelial tube; and gut section. Orthologous to human SLC12A9 (solute carrier family 12 member 9)." FBgn0003270 UniProtKB Transcription factor involved in early neurogenesis; sensillum basiconica formation and maybe sensillum trichodea development. Promotes multiple dendritic (MD) neuron formation. Required for olfactory sensilla; regulated by lozenge (lz). (UniProtKB:Q9Y0A7) FBgn0032683 FlyBase Gene Snapshot kon-tiki (kon) (also known as perdido) encodes a single transmembrane protein required to initiate muscle-tendon attachment in a group of embryonic and adult body muscles. kon mutants are embryonic lethal with rounded ventral longitudinal muscles. It concentrates at muscle attachment sites and genetically interacts with integrins. FBgn0032681 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be located in cytoplasm. Is expressed in dorsal ectoderm anlage; organism; trunk mesoderm anlage; and ventral ectoderm anlage. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 44 and mantle cell lymphoma. Orthologous to human CCDC50 (coiled-coil domain containing 50). FBgn0032698 UniProtKB Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). (UniProtKB:Q8INX3) FBgn0032700 Alliance "Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval nervous system; ganglia; and garland cell primordium. Orthologous to human RUSF1 (RUS family member 1)." FBgn0032701 UniProtKB "RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1/CG4038 to yield mature H/ACA snoRNPs complex (By similarity). (UniProtKB:Q9VJ62)" FBgn0032703 Alliance Orthologous to human RWDD4 (RWD domain containing 4). FBgn0032705 FlyBase Gene Snapshot "Grip71 (Grip71) encodes a recruitment adapter protein for multi-protein gamma-tubulin ring complexes (gammaTuRCs), which template microtubule nucleation. It associates with gammaTuRCs, but is not required for their assembly. Grip71 is required, however, for gammaTuRC localisation to spindle microtubules and to centrosomes once other recruitment pathways have been removed." FBgn0040993 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0027074 Alliance "Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0032713 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in several structures, including Johnston organ neurons; epithelium; fat body; lobula columnar neurons; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0027070 Alliance "Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0015808 Alliance "Predicted to enable acetyl-CoA C-acyltransferase activity; phospholipid transporter activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to be involved in phospholipid transport. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human SCP2 (sterol carrier protein 2)." FBgn0032719 Alliance "Predicted to be active in membrane. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; and ganglia." FBgn0003896 FlyBase Gene Snapshot "tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development." FBgn0053120 Alliance Predicted to enable O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0032717 Alliance Predicted to enable histone H4K20 demethylase activity. Predicted to be active in nucleus. Orthologous to several human genes including RSBN1 (round spermatid basic protein 1). FBgn0032715 Alliance Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be active in peroxisome. Is expressed in adult head; adult heart; embryonic Malpighian tubule; embryonic/larval midgut; and organism. Orthologous to human SCP2 (sterol carrier protein 2). FBgn0045852 FlyBase Gene Snapshot hamlet (ham) encodes a PRDM family transcription factor that regulates neuron fate selection in the peripheral nervous system and olfactory receptor neurons. It also controls intermediate precursor cell maturation in the type II neuroblast lineages of the larval brain. FBgn0032707 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal ridge; dorsal ridge primordium; embryonic head epidermis; embryonic/larval posterior spiracle; and head epidermis primordium. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus)." FBgn0032706 FlyBase Gene Snapshot Inwardly rectifying potassium channel 3 (Irk3) encodes a protein involved in wing disc development. FBgn0025608 FlyBase Gene Snapshot Fas-associated factor 2 (Faf2) encodes a putative E3 ligase adaptor protein with a proteosome dependent function. FBgn0032704 Alliance Involved in response to ethanol. Located in endomembrane system. Is expressed in adult head and adult heart. Used to study alcohol use disorder. Orthologous to several human genes including PRAF2 (PRA1 domain family member 2). FBgn0032702 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Predicted to be located in cytoplasm and nucleus. Is expressed in lamina. Orthologous to several human genes including PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F)." FBgn0005617 FlyBase Gene Snapshot "male-specific lethal 1 (msl-1) encodes a protein that is thought to form a scaffold to organize the full male-specific-lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. msl-1 homozygous mutant males die as larvae, while females are viable." FBgn0015553 UniProtKB 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). (UniProtKB:Q24558) FBgn0032724 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; somatic muscle primordium; spermatozoon; and visceral muscle primordium. Orthologous to human GSTCD (glutathione S-transferase C-terminal domain containing)." FBgn0032728 UniProtKB May be involved in protein secretion and Golgi organization. (UniProtKB:Q9VJ29) FBgn0032730 Alliance Predicted to enable chromatin insulator sequence binding activity and transcription cis-regulatory region binding activity. Involved in dendrite morphogenesis. Predicted to be located in nucleus. Predicted to be active in chromosome. Is expressed in organism. FBgn0032732 Alliance Predicted to enable inorganic cation transmembrane transporter activity. Involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be part of EMC complex. Predicted to be active in Golgi apparatus; early endosome; and plasma membrane. Is expressed in adult head; adult heart; and organism. Orthologous to human MMGT1 (membrane magnesium transporter 1). FBgn0051792 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0051793 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and organism. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0028569 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. FBgn0032741 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; eye; ganglia; and spermatozoon. Orthologous to several human genes including BHLHE40 (basic helix-loop-helix family member e40); BHLHE41 (basic helix-loop-helix family member e41); and HES3 (hes family bHLH transcription factor 3)." FBgn0002022 UniProtKB Negatively regulates tyrosine hydroxylase activity. (UniProtKB:Q9V3A4) FBgn0032746 Alliance "Predicted to enable calcium channel activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1)." FBgn0032748 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Orthologous to several human genes including ZCCHC14 (zinc finger CCHC-type containing 14). FBgn0032749 FlyBase Gene Snapshot PH domain leucine-rich repeat protein phosphatase (Phlpp) encodes an enzyme involved in apoptosis regulation and tumor growth suppression via dephosphorylation of the product of Akt. FBgn0032750 Alliance Predicted to enable tRNA-dihydrouridine20a synthase activity and tRNA-dihydrouridine20b synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS4L (dihydrouridine synthase 4 like). FBgn0000075 FlyBase Gene Snapshot alpha methyl dopa-resistant (amd) encodes a carboxy-lyase involved in catecholamine metabolism. FBgn0002036 UniProtKB Has a non-vital function. (UniProtKB:P18487) FBgn0010300 FlyBase Gene Snapshot "brain tumor (brat) encodes a tumor suppressor that regulates proliferation in the brain. During neural stem cell division, it segregates into one daughter cell where it inhibits protein translation, preventing self-renewal and inducing differentiation. It also acts during oogenesis where it interacts with the products of nanos and pum to suppress hb translation." FBgn0002031 UniProtKB Required for larval metabolism or for the progression of the larva into a pupa. (UniProtKB:P24156) FBgn0000422 Alliance "Enables 5-hydroxy-L-tryptophan decarboxylase activity and L-dopa decarboxylase activity. Involved in several processes, including adult chitin-containing cuticle pigmentation; aromatic amino acid metabolic process; and memory. Predicted to be active in cytoplasm. Is expressed in several structures, including aminergic neurons; epithelium; ganglia; gut section; and mushroom body medial lobe. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase)." FBgn0002023 FlyBase Gene Snapshot "Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity." FBgn0032754 Alliance "Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in endoplasmic reticulum and mitochondrial inner membrane. Predicted to be active in cytoplasm. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3)." FBgn0032753 Alliance Predicted to be involved in proteolysis. Is expressed in embryonic antennal sense organ; embryonic head sensory system; embryonic/larval muscle system; and embryonic/larval posterior spiracle. FBgn0032752 Alliance "Is expressed in several structures, including adult brain; adult head; embryonic head sensory system; glial cell; and mesoderm." FBgn0002021 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle cell. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1)." FBgn0032744 UniProtKB Required for mitochondrial complex III formation. (UniProtKB:Q8SYD0) FBgn0051800 Alliance Is expressed in organism. Orthologous to human C1orf50 (chromosome 1 open reading frame 50). FBgn0001202 FlyBase Gene Snapshot "hook (hook) encodes a microtubule-binding protein involved in cytoskeleton-dependent intracellular transport. Its knockdown results in hooked bristles, but it is not required for viability." FBgn0046302 Alliance Is expressed in adult head; embryonic midgut chamber; and embryonic/larval midgut. FBgn0032733 Alliance Involved in wound healing. FBgn0032731 FlyBase Gene Snapshot "Swiprosin-1 (Swip-1) encodes a calcium binding protein, expressed in fusion competent myoblasts and macrophages of the embryo." FBgn0032729 Alliance "Enables 2-hydroxyglutarate dehydrogenase activity, forward reaction. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; L-2-hydroxyglutaric aciduria; cerebellar ataxia; hereditary spastic paraplegia; and visual epilepsy. Orthologous to human L2HGDH (L-2-hydroxyglutarate dehydrogenase)." FBgn0015772 FlyBase Gene Snapshot Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization. FBgn0032727 Alliance Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity; S-methylmethionine-homocysteine S-methyltransferase activity; and betaine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process. Is expressed in yolk nucleus. FBgn0032726 Alliance "Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process. Is expressed in several structures, including adult fat body; amnioserosa; embryonic/larval crystal cell; procrystal cell; and yolk nucleus." FBgn0032725 FlyBase Gene Snapshot "Nedd8 (Nedd8) encodes a ubiquitin-like polypeptide involved in protein ubiquitination and degradation, via Cullin neddylation. Nedd8-mediated modification has been implicated in signal transduction, cell proliferation and differentiation." FBgn0032723 Alliance Located in spindle. Is expressed in adult head. Used to study Bardet-Biedl syndrome and azoospermia. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). FBgn0010309 FlyBase Gene Snapshot pigeon (pigeon) encodes a member of the Gamma-secretase-activating protein family. FBgn0015380 FlyBase Gene Snapshot derailed (drl) encodes an atypical receptor tyrosine kinase with the product of Wnt5 as a ligand. It controls axon guidance events during neural development. FBgn0032769 Alliance Is expressed in chordotonal neurons and spermatogonium. Orthologous to human CFAP73 (cilia and flagella associated protein 73) and CCDC42 (coiled-coil domain containing 42). FBgn0032770 Alliance Predicted to enable carbohydrate binding activity. FBgn0032771 Alliance Predicted to enable G protein-coupled receptor binding activity; Hsp70 protein binding activity; and Hsp90 protein binding activity. Predicted to be located in cytosol and nucleus. Is expressed in spermatozoon. Orthologous to human PACRG (parkin coregulated). FBgn0016675 FlyBase Gene Snapshot Galactose-specific C-type lectin (Lectin-galC1) encodes a galactose binding protein involved in the induction of bacterial agglutination and cell-cell adhesion. FBgn0032780 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0032779 Alliance Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in adult head and adult heart. FBgn0032781 UniProtKB "Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (UniProtKB:Q9VIW7)" FBgn0032782 FlyBase Gene Snapshot Rab9 (Rab9) encodes a member of the Rab subfamily of small GTPases associated with late endosomes. It promotes membrane budding and retrograde recycling of endocytosed materials to the Golgi apparatus. Its roles include recycling of tracheal luminal proteins and tracheal tube length control. FBgn0032783 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head and organism. Orthologous to human TTPAL (alpha tocopherol transfer protein like). FBgn0032775 Alliance "Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Located in peroxisome. Is expressed in several structures, including adult head; dorsal sensory complex primordium; dorsal sensory complex proper primordium; embryonic hindgut; and ganglia. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl)." FBgn0032774 Alliance "Is expressed in several structures, including adult head; adult heart; clypeo-labral primordium; gut section; and sensory nervous system primordium." FBgn0032773 FlyBase Gene Snapshot fondue (fon) encodes a protein produced by the fat body that is involved in the clotting reaction. FBgn0024245 FlyBase Gene Snapshot doughnut on 2 (dnt) encodes a Ryk family Wnt receptor-tyrosine kinase-related protein. It can form homo- and heterodimers with the other two Ryks (encoded by Drl-2 and drl) via binding the ligand encoded by Wnt5. dnt and drl products act during embryonic muscle attachment site selection. FBgn0032768 Alliance Is expressed in chordotonal neurons and spermatogonium. Orthologous to human CFAP73 (cilia and flagella associated protein 73) and CCDC42 (coiled-coil domain containing 42). FBgn0051797 Alliance Is expressed in spermatozoon. FBgn0010097 FlyBase Gene Snapshot gamma-Tubulin at 37C (gammaTub37C) encodes a maternally expressed member of the tubulin family. It localizes predominantly to centrosomes and plays an essential role in microtubule nucleation at the centrosomes. FBgn0003346 UniProtKB "GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). (UniProtKB:Q9VIW3)" FBgn0032785 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; embryonic ventral epidermis; and embryonic/larval fat body. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0000964 FlyBase Gene Snapshot traffic jam (tj) encodes a Maf transcription factor that functions as regulator of multiple gonad morphogenesis processes including collective cell migration during oogenesis and stem cell specification downstream of Notch signaling during spermatogenesis. FBgn0032788 Alliance Located in egg chorion. FBgn0032791 Alliance "Predicted to enable hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides. Orthologous to human NUDT19 (nudix hydrolase 19)." FBgn0002044 UniProtKB Negatively regulates Hedgehog (hh) protein signal in wing development (PubMed:18245841). Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells (PubMed:21203496). (UniProtKB:Q9VIV2) FBgn0040268 FlyBase Gene Snapshot Topoisomerase 3alpha (Top3alpha) encodes a type IA topoisomerase that works with the helicase encoded by Blm to perform double Holliday junction dissolution during homologous recombination. It is also involved in DNA disentangling during chromosome segregation and mitochondrial DNA replication. FBgn0032798 Alliance "Is expressed in several structures, including adult head; embryonic/larval muscle system; embryonic/larval nervous system; ganglia; and sensory nervous system primordium." FBgn0032800 Alliance Involved in centriole elongation. Located in centriole. Human ortholog(s) of this gene implicated in Joubert syndrome 25 and autosomal recessive intellectual developmental disorder 77. Orthologous to human CEP104 (centrosomal protein 104). FBgn0053116 Alliance "Predicted to enable ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; central brain primordium; ganglia; primordial germ cell; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to human SELENOI (selenoprotein I)." FBgn0032803 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic large intestine; embryonic ventral epidermis; and gut section." FBgn0041180 FlyBase Gene Snapshot Thioester-containing protein 4 (Tep4) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep4 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. FBgn0032809 Alliance Predicted to enable heme binding activity and transmembrane ascorbate ferrireductase activity. Orthologous to human CYB561D1 (cytochrome b561 family member D1) and CYB561D2 (cytochrome b561 family member D2). FBgn0032810 Alliance Predicted to enable heme binding activity and transmembrane ascorbate ferrireductase activity. Is expressed in adult head and photoreceptor neurons. Orthologous to several human genes including CYB561D2 (cytochrome b561 family member D2). FBgn0027949 Alliance "Is expressed in several structures, including central brain primordium; embryonic ventral epidermis; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium." FBgn0032814 Alliance Enables DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). FBgn0000464 FlyBase Gene Snapshot "Leukocyte-antigen-related-like (Lar) encodes a transmembrane receptor tyrosine phosphatase with a extracellular domain that binds to the product of Sdc. It regulates signaling through the product of Abl. While the product of Lar has many functions, it is best known for its roles in embryonic motor axon guidance and in target recognition by axons of R7 photoreceptors." FBgn0005590 FlyBase Gene Snapshot screw (scw) encodes a BMP-type ligand that forms a heterodimer with the product of dpp. The heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa. FBgn0032813 UniProtKB Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility (PubMed:17087725). May function independently of PCNA during DNA repair (PubMed:17087725). (UniProtKB:Q9VIT0) FBgn0032811 Alliance "Predicted to enable phosphomevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase)." FBgn0032805 Alliance Predicted to enable heme binding activity and transmembrane ascorbate ferrireductase activity. Is expressed in adult head. FBgn0032801 Alliance Predicted to enable heme binding activity and transmembrane ascorbate ferrireductase activity. Orthologous to several human genes including CYB561D2 (cytochrome b561 family member D2). FBgn0032799 UniProtKB "Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (UniProtKB:Q9VIU7)" FBgn0032797 Interactive Fly "component of synaptic cleft of brain cholinergic synapses, regulates levels of Discs large and nAChR subunits at postsynaptic terminals, required for trapping Hikaru genki at the synapse" FBgn0032796 Interactive Fly "RhoGEF that maintains tissue polarity and integrity - together with RhoGEF4 plays roles to couple cytokinesis with de novo junction formation - acts via Rho1, participating in the neighbor mechanosensing response, promoting daughter-daughter cell membrane juxtaposition in preparation to de novo junction formation - Crumbs and its complex partner Cysts support myosin and apical constriction to ensure robust ingression dynamics - recruited to the apico-lateral membrane through interactions with the Crumbs complex and Bazooka/Par3 - required for cell intercalation in the extending ectoderm, where it activates Rho1 specifically at junctions - localization is restricted to adherens junctions and is under Gbeta13F/ Ggamma1 control - Myosin VI promotes recruitment of the heterotrimeric Galpha12 protein to E-cadherin, where it signals for p114 RhoGEF to activate RhoA" FBgn0032793 UniProtKB "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (UniProtKB:Q9VIV3)" FBgn0032790 Alliance "Predicted to enable hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides. Orthologous to human NUDT19 (nudix hydrolase 19)." FBgn0032787 Alliance "Predicted to enable hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides. Orthologous to human NUDT19 (nudix hydrolase 19)." FBgn0024230 FlyBase Gene Snapshot "Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways." FBgn0032816 FlyBase Gene Snapshot "Nuclear factor Y-box B (Nf-YB) encodes a subunit of the nuclear transcription factor Y, which binds to the CCAAT box regulatory sequence. It regulates gene transcription and is involved in eye and thorax development." FBgn0032819 Alliance Predicted to enable tRNA-dihydrouridine47 synthase activity. Predicted to be involved in tRNA processing. Orthologous to human DUS3L (dihydrouridine synthase 3 like). FBgn0032822 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Orthologous to human RBMX2 (RNA binding motif protein X-linked 2)." FBgn0003931 Alliance "Predicted to enable U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U4 snRNP." FBgn0003923 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in Cajal body." FBgn0043021 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0032833 FlyBase Gene Snapshot Cytochrome c oxidase subunit 4 (COX4) encodes a subunit of the cytochrome-c oxidase. It is involved in cell proliferation and golgi structural organisation. FBgn0014000 Alliance Involved in innate immune response. FBgn0042129 Alliance Involved in sensory perception of smell. Located in nucleus. Is expressed in adult antennal olfactory receptor neurons; antenna; maxillary palp olfactory receptor neurons; olfactory sensory organ; and third segment of antenna. FBgn0032834 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0053117 UniProtKB A humoral factor that may play a role in stress tolerance. (UniProtKB:Q8INV7) FBgn0044811 UniProtKB A humoral factor that may play a role in stress tolerance. (UniProtKB:Q9VIR2) FBgn0032827 Alliance Predicted to enable inositol hexakisphosphate binding activity and phosphate transmembrane transporter activity. Predicted to be involved in cellular response to phosphate starvation and phosphate ion transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. FBgn0003922 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in Cajal body." FBgn0043022 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP." FBgn0004811 Alliance Involved in chorion-containing eggshell formation. Is expressed in organism. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SLC7A6OS (solute carrier family 7 member 6 opposite strand). FBgn0032821 FlyBase Gene Snapshot "Cd GTPase activating protein-related (CdGAPr) encodes a protein that acts in concert with the product of Fak in the formation of the optic stalk, a tubular structure composed of glial cells." FBgn0032820 FlyBase Gene Snapshot "Fructose bisphosphatase (Fbp) encodes a putative enzyme that is predicted to dephosphorylate fructose 1,6-bisphosphate to fructose 6-phosphate, acting as a rate-limiting enzyme in gluconeogenesis." FBgn0032818 UniProtKB May be involved in the ribosome maturation process. (UniProtKB:Q9I7M2) FBgn0032817 Alliance "Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gastric caecum; posterior endoderm; and spermatozoon. Orthologous to human ZNF212 (zinc finger protein 212) and ZNF671 (zinc finger protein 671)." FBgn0032840 FlyBase Gene Snapshot "short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep." FBgn0019686 UniProtKB May have a role in germline establishment. (UniProtKB:O61267) FBgn0045064 UniProtKB Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (UniProtKB:Q9VIP7) FBgn0004374 FlyBase Gene Snapshot nebbish (neb) encodes a microtubule motor protein that interacts with PP1 phosphatases and is involved in chromosome segregation. FBgn0032846 UniProtKB Probable oxidoreductase. (UniProtKB:Q9VIP2) FBgn0032848 UniProtKB Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides. (UniProtKB:Q9VIP0) FBgn0032850 Alliance Predicted to enable plasmanylethanolamine desaturase activity. Predicted to be located in membrane. Is expressed in embryonic antennal sense organ. Orthologous to human PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough) and PEDS1 (plasmanylethanolamine desaturase 1). FBgn0032849 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult heart; embryonic/larval midgut; and organism. Orthologous to human MRPS18B (mitochondrial ribosomal protein S18B). FBgn0032847 Alliance "Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be part of transcription factor TFIID complex. Is expressed in several structures, including antennal anlage; antennal primordium; anterior endoderm; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 60. Orthologous to human TAF13 (TATA-box binding protein associated factor 13)." FBgn0032845 Alliance "Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human PLCXD2 (phosphatidylinositol specific phospholipase C X domain containing 2) and PLCXD3 (phosphatidylinositol specific phospholipase C X domain containing 3)." FBgn0032843 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0003978 FlyBase Gene Snapshot valois (vls) encodes a protein that functions as the substrate recognition platform for the protein arginine methyltransferase encoded by csul. Primary substrates of the products of csul and vls are the spliceosomal Sm proteins. The product of vls is also required for proper localization of the product of tud to the posterior pole of the oocyte during germ line specification. FBgn0014127 FlyBase Gene Snapshot barren (barr) encodes a chromatin binding protein involved in chromatin condensation. It regulates Malpighian tubule development and epithelial morphogenesis. FBgn0032839 Alliance Predicted to enable aralkylamine N-acetyltransferase activity. Is expressed in adult head. FBgn0040996 Alliance Is expressed in adult head and spermatozoon. FBgn0003475 FlyBase Gene Snapshot "spire (spir) encodes a de novo WH2 domain-containing actin nucleation factor that polymerizes linear actin filaments, as well as bundles and/or crosslinks actin and microtubules. It is a downstream effector of the product of Rho1 and is involved in many cytoskeleton related developmental processes, including ooplasmic streaming, nurse cell architecture, and endocytosis." FBgn0015803 FlyBase Gene Snapshot "Rho-type guanine nucleotide exchange factor (RtGEF) encodes a putative Rho-type guanine nucleotide exchange factor for the GTPases encoded by Rac1 and Cdc42. It signals through the sterile-20 kinases encoded by Pak and hpo. The product of RtGEF contributes to regulation of postsynaptic structure, post synaptic muscle development, protein localization and the growth of epithelial tissue." FBgn0032857 Alliance Predicted to enable calmodulin-lysine N-methyltransferase activity. Predicted to be involved in regulation of translation. Predicted to be located in cytoplasm and nucleus. Is expressed in antennal disc; eye disc; leg disc; and wing disc. Orthologous to human CAMKMT (calmodulin-lysine N-methyltransferase). FBgn0032856 Alliance "Is expressed in several structures, including dorsal imaginal tissue; embryonic head epidermis; embryonic head sensory system; embryonic ventral epidermis; and epithelium." FBgn0026756 Alliance Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6) and UGT2A3 (UDP glucuronosyltransferase family 2 member A3). FBgn0011638 UniProtKB May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development. (UniProtKB:P40796) FBgn0032853 Alliance Involved in sexual reproduction. Located in extracellular space. Orthologous to human GLIPR1 (GLI pathogenesis related 1) and CRISP1 (cysteine rich secretory protein 1). FBgn0032868 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0051680 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0032870 Alliance Predicted to enable nucleic acid binding activity. Is expressed in organism. Orthologous to human SPAG7 (sperm associated antigen 7). FBgn0042133 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in Golgi apparatus. Is expressed in embryonic/larval central nervous system. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0032871 Alliance Predicted to be active in endomembrane system. Orthologous to human TMEM230 (transmembrane protein 230). FBgn0032873 UniProtKB Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus. (UniProtKB:Q9VIK9) FBgn0032877 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm. Orthologous to human RNF26 (ring finger protein 26). FBgn0032880 Alliance "Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gland; gut section; and mesoderm. Orthologous to human TM9SF2 (transmembrane 9 superfamily member 2)." FBgn0032879 FlyBase Gene Snapshot "Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine." FBgn0032878 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0014859 FlyBase Gene Snapshot Hormone receptor-like in 38 (Hr38) encodes a protein that can heterodimerize with the U adult cuticle and for the proper uptake and storage of glycogen in larvae. FBgn0032876 FlyBase Gene Snapshot "Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures." FBgn0051678 Alliance Predicted to be located in rough endoplasmic reticulum. Predicted to be active in cytoplasm and membrane. Is expressed in adult head. Orthologous to human SUCO (SUN domain containing ossification factor). FBgn0016054 FlyBase Gene Snapshot (6-4)-photolyase (phr6-4) encodes an enzyme that repairs DNA damage induced by ultraviolet light. It uses blue light and cofactor FADH to reverse the pyrimidine(6-4)pyrimidone photoproduct. FBgn0032869 Alliance Involved in mesoderm development. FBgn0032882 Alliance Predicted to enable GTPase activity. Is expressed in organism. Orthologous to human GNL1 (G protein nucleolar 1 (putative)). FBgn0011202 FlyBase Gene Snapshot "diaphanous (dia) encodes the sole Dia-class formin in Drosophila. It nucleates actin filaments de novo and acts as a processive actin polymerase, stimulating actin addition at the barbed end. It plays an essential role in cytokinesis and also regulates cell shape change and protrusion." FBgn0000251 FlyBase Gene Snapshot "caudal (cad) encodes a transcription factor involved in processes such as anterior/posterior patterning formation, organ morphogenesis and innate immune homeostasis." FBgn0032884 Alliance Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 2. Orthologous to human POMP (proteasome maturation protein). FBgn0032886 Alliance Predicted to be involved in regulation of cell growth. Predicted to be located in nucleus. Orthologous to several human genes including FAM107B (family with sequence similarity 107 member B). FBgn0032889 Alliance "Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic head epidermis; and embryonic/larval midgut." FBgn0051673 Alliance Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in organism. FBgn0051674 Alliance Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in adult head. FBgn0051676 Alliance "Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic head epidermis; embryonic head sensory system; and embryonic precursor of adult hindgut." FBgn0032894 FlyBase Gene Snapshot "CG14402 encodes a protein which contains a VTD-type deubiquitinase domain. It is most likely inactive, since crucial active site residues are missing." FBgn0032895 FlyBase Gene Snapshot "target of wit (twit) encodes a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the BMP pathway receptor encoded by wit. It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions." FBgn0032897 FlyBase Gene Snapshot "belly roll (bero) encodes a protein required for suppressing nociceptive escape behavior, and is expressed in larval abdominal leucokinin-producing (ABLK) neurons. ABLK neuron-specific bero knockdown causes both enhanced nociceptive neural response and accelerated nociceptive escape behavior." FBgn0032899 UniProtKB May be involved in regulating neuron excitability. (UniProtKB:Q9VIH9) FBgn0051675 Alliance Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in dorsal sensory complex proper primordium and embryonic dorsal epidermis. FBgn0032900 Alliance Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in adult heart. FBgn0032908 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0032901 FlyBase Gene Snapshot "skywalker (sky) encodes a RabGAP that genetically interacts with and activates GTPase activity of the product of Rab35 through an unconventional mechanism. It restricts the ability of synaptic vesicles to fuse into a synaptic endosomal compartment, thereby limiting synaptic vesicle associated protein sorting at synaptic endosomes. In line with this function, sky also genetically interacts with components of the ESCRT and HOPS complexes." FBgn0028986 FlyBase Gene Snapshot Serpin 38F (Spn38F) encodes a predicted serine endopeptidase inhibitor. It is expressed in the male accessory glands and transferred to females during mating. Spn38F ectopic expression in females provides anti-microbial protection. FBgn0032891 Alliance Involved in cilium assembly. Located in non-motile cilium. Is expressed in Johnston organ neurons; chordotonal neurons; eo neurons; and wing disc. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Orthologous to human IFT80 (intraflagellar transport 80). FBgn0067312 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg. FBgn0032883 FlyBase Gene Snapshot RHAU helicase (Rhau) encodes a protein involved in G-quadruplex DNA unwinding. FBgn0032881 Alliance Predicted to enable alpha-methylacyl-CoA racemase activity. Predicted to be involved in bile acid metabolic process. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase). FBgn0010395 UniProtKB "Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth. (UniProtKB:Q27591)" FBgn0032911 Alliance Enables L-histidine transmembrane transporter activity. Involved in histidine transport. Predicted to be active in plasma membrane. FBgn0032913 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0032916 Alliance Predicted to enable carbohydrate binding activity. Located in endomembrane system. Is expressed in adult head. Orthologous to human MLEC (malectin). FBgn0040297 FlyBase Gene Snapshot "Na[+]/H[+] hydrogen exchanger 2 (Nhe2) encodes a Na-H exchanger of the SLC family 9A that increases intracellular pH. The product of Nhe2 activity promotes proliferation, morphogenesis and planar cell polarity, and contributes to oncogene-induced metastatic cell behaviors." FBgn0032919 UniProtKB "Part of a translational control module, also containing ath/DHX33 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation (PubMed:35413237). With atos, adjusts transcription and translation of a subset of OXPHOS genes in macrophages to increase mitochondrial bioenergetics and allow tissue invasion (PubMed:35319107). (UniProtKB:Q9VIF6)" FBgn0032921 Alliance Predicted to be involved in maturation of 5.8S rRNA. Is expressed in organism. Orthologous to human MPHOSPH6 (M-phase phosphoprotein 6). FBgn0032923 Alliance Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in regulation of cytokine production involved in inflammatory response. Predicted to be located in endoplasmic reticulum membrane and lysosomal lumen. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to several human genes including PLD3 (phospholipase D family member 3). FBgn0032925 Alliance "Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and ribosomal large subunit biogenesis. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor)." FBgn0010100 FlyBase Gene Snapshot "Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate." FBgn0051627 Alliance Is expressed in organism. FBgn0032929 UniProtKB Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation. (UniProtKB:Q9VIE6) FBgn0026255 Alliance Predicted to enable kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and regulation of synaptic activity. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult head and transmedullary neuron Tm5c. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). FBgn0026577 FlyBase Gene Snapshot CG8677 encodes a protein that dimerizes with the product of Iswi to form a chromatin remodeling factor RSF (remodeling and spacing factor). RSF is involved in silent chromatin formation via replacement of the product of His2Av. FBgn0021856 Alliance Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be active in mitochondrion. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). FBgn0032938 Alliance Involved in dsRNA transport. Is expressed in organism. Orthologous to human EEIG2 (EEIG family member 2) and EEIG1 (estrogen-induced osteoclastogenesis regulator 1). FBgn0051626 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in embryonic dorsal epidermis; embryonic esophagus; embryonic foregut; embryonic head epidermis; and embryonic ventral epidermis. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). FBgn0032935 Alliance "Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Involved in cellular response to oxidative stress. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2)." FBgn0032934 Alliance Predicted to enable DNA endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination and resolution of meiotic recombination intermediates. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1). FBgn0003930 Alliance "Predicted to enable U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U4 snRNP." FBgn0011829 FlyBase Gene Snapshot Ret oncogene (Ret) encodes a cell surface receptor mediating dendrite development of class IV dendritic arborization sensory neurons. It interacts with integrins and mediates rac1 signaling to promote dendrite adhesion to the extracellular matrix. FBgn0000239 FlyBase Gene Snapshot burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. FBgn0032924 UniProtKB "Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation. (UniProtKB:Q9VIF1)" FBgn0032922 Alliance "Predicted to enable 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity and 3-demethylubiquinol-n 3-O-methyltransferase activity. Involved in wound healing. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human COQ3 (coenzyme Q3, methyltransferase)." FBgn0024371 FlyBase Gene Snapshot "E2F transcription factor 2 (E2f2) encodes a transcription factor that belongs to the E2F gene family. It is a subunit of the DREAM complex, where it forms a heterodimer with the product of Dp to bind to DNA and repress transcription. Among their trancription targets are cell cycle genes and differentiation related genes." FBgn0023388 FlyBase Gene Snapshot "Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division." FBgn0032910 Alliance Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be active in lipid droplet. Is expressed in adult brain; adult head; and organism. Orthologous to several human genes including SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). FBgn0023091 FlyBase Gene Snapshot dimmed (dimm) encodes a bHLH transcription factor of the Neuro D family that is associated with high levels of protein secretion. It does not specify a pro-secretory cell fate but promotes the cellular properties to support that fate. FBgn0032943 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in prostate adenocarcinoma. Orthologous to human CD9 (CD9 molecule). FBgn0023090 UniProtKB Cilium-specific protein required for cilia structures. (UniProtKB:Q8INT5) FBgn0032945 Alliance "Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval crystal cell; embryonic/larval fat body; and embryonic/larval midgut. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1) and ALDH1L2 (aldehyde dehydrogenase 1 family member L2)." FBgn0032946 FlyBase Gene Snapshot "nervana 3 (nrv3) encodes one of three beta subunits of the sodium-potassium pump (ATPalpha). nrv3 is expressed in the nervous system, including subsets of the CNS and Johnston's organ neurons, and is required for hearing." FBgn0041245 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Has also atypical sensory function in organ not limited to conventional taste sensing like abdominal ganglions. (UniProtKB:P58960)" FBgn0032940 FlyBase Gene Snapshot "Mondo (Mondo) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis. Mondo mutants are intolerant to dietary sugars and have impaired muscle function." FBgn0037501 FlyBase Gene Snapshot Ionotropic receptor 84a (Ir84a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of phenylacetic acid and controls male courtship behavior. FBgn0037502 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0037503 Alliance Is expressed in embryonic dorsal epidermis and embryonic/larval posterior spiracle. FBgn0011999 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003885 FlyBase Gene Snapshot alpha-Tubulin at 84D (alphaTub84D) encodes a protein involved in major cellular mechanisms such as formation of spindle apparatus or microtubular threads for transport of proteins or organelles. FBgn0015570 Alliance Enables carboxylesterase activity. Is expressed in adult head; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0051146 FlyBase Gene Snapshot Neuroligin 1 (Nlg1) encodes a transsynaptic adhesion protein of the neuroligin family that is expressed in muscles and accumulates at the postsynaptic side of neuromuscular junctions. Lack of Nlg1 causes smaller and underdeveloped neuromuscular junctions due to insufficient postsynaptic maturation and differentiation of synaptic boutons. FBgn0015568 Alliance "Enables serine hydrolase activity. Is expressed in several structures, including adult head; germline cell; gut section; posterior ectoderm anlage; and posterior endoderm. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3)." FBgn0015571 Alliance Enables serine hydrolase activity. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0015572 Alliance Predicted to enable carboxylesterase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0015831 Alliance Enables phospholipid binding activity. Involved in endoplasmic reticulum tubular network organization and membrane bending. Is active in endoplasmic reticulum membrane. FBgn0015574 Alliance Predicted to enable carboxylesterase activity. Is expressed in organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0015575 FlyBase Gene Snapshot "alpha-Esterase-7 (alpha-Est7) encodes a carboxylic ester hydrolase involved in insecticide tolerance, lipid metabolism and lifespan control." FBgn0017456 UniProtKB Catalyzes the covalent attachment of ubiquitin to other proteins. (UniProtKB:P52487) FBgn0015576 Alliance Predicted to enable carboxylesterase activity. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0037506 FlyBase Gene Snapshot "Mitochondrial morphology and cristae structure 1 (Mics1) encodes an inner mitochondrial membrane protein. It interacts with the protein encoded by Chchd2 and enhances oxidative phosphorylation. By orthology, it is predicted to play a role in the maintenance of mitochondrial morphology and the negative regulation of apoptotic cytochrome c release." FBgn0015577 Alliance Predicted to enable carboxylesterase activity. Is expressed in organism. Orthologous to human CES2 (carboxylesterase 2). FBgn0015569 Alliance "Enables serine hydrolase activity. Is expressed in several structures, including adult head; embryonic/larval anterior midgut; embryonic/larval central nervous system; fat body; and nephrocyte. Orthologous to human CES3 (carboxylesterase 3) and CES4A (carboxylesterase 4A)." FBgn0012001 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037504 Alliance Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2). FBgn0043853 Alliance Predicted to be involved in RNA processing. Located in Cajal body. FBgn0012000 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0040670 UniProtKB Testis-specific paralog of the ubiquitously expressed transcription and mRNA export factor e(y)2. Cannot functionally replace e(y)2. (UniProtKB:Q9VI60) FBgn0037472 Alliance Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including SCRN3 (secernin 3). FBgn0051248 Alliance Predicted to enable N-acetyltransferase activity. FBgn0051494 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051493 Alliance Predicted to enable N-acetyltransferase activity. Involved in sexual reproduction. FBgn0037475 FlyBase Gene Snapshot "48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N." FBgn0037478 Alliance "Predicted to enable GTPase activity. Is expressed in several structures, including adult pars intercerebralis; brain; central brain primordium; embryonic central brain neurons; and embryonic/larval midgut primordium. Orthologous to human GPN3 (GPN-loop GTPase 3)." FBgn0011020 FlyBase Gene Snapshot "Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole." FBgn0002306 FlyBase Gene Snapshot "stranded at second (sas) encodes a single-pass transmembrane protein that localizes to the apical cell surface in polarized epithelia, such as the embryonic/larval salivary gland (SG). Overexpression of sas in the developing SG leads to all membrane domains taking on apical membrane character, with the exception of the region where septate junctions form." FBgn0037483 Alliance Is expressed in adult head and spermatozoon. FBgn0037487 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0037488 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0037490 Alliance "Predicted to enable nucleic acid binding activity. Predicted to be active in kinetochore. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human GPATCH11 (G-patch domain containing 11)." FBgn0037492 UniProtKB Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). (UniProtKB:Q9VI85) FBgn0028400 FlyBase Gene Snapshot Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment. FBgn0045843 UniProtKB Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac-bound GDP by GTP. (UniProtKB:P40809) FBgn0051496 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0004172 Alliance Involved in sperm axoneme assembly. FBgn0004173 Alliance Involved in sperm axoneme assembly. FBgn0004174 Alliance Involved in sperm axoneme assembly. FBgn0004175 Alliance Involved in sperm axoneme assembly. FBgn0037498 Alliance Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult head. Orthologous to human ERP44 (endoplasmic reticulum protein 44). FBgn0001112 FlyBase Gene Snapshot Glucose dehydrogenase (Gld) encodes a dehydrogenase that belongs to the GMC oxidoreductase family. The product of Gld is essential for the enzymatic modification of the puparium wall that enables the newly developed adult fly to eclose. Gld is also highly expressed in the male and female reproductive tract and its product modulates sperm storage and utilization. FBgn0011282 Alliance Predicted to enable pheromone binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. Is expressed in antenna and antennal sense organ. FBgn0037491 Alliance Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of cell size. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human STK16 (serine/threonine kinase 16). FBgn0037489 Alliance "Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of Noc2p-Noc3p complex. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle system; and gut section. Orthologous to human NOC3L (NOC3 like DNA replication regulator)." FBgn0037486 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0037485 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0037482 UniProtKB Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs). (UniProtKB:Q9VI74) FBgn0037481 FlyBase Gene Snapshot "MAGE (MAGE) encodes a component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes." FBgn0051491 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037473 Alliance Predicted to enable GTPase activator activity. Is expressed in adult head and organism. Orthologous to several human genes including ELMOD2 (ELMO domain containing 2). FBgn0014863 FlyBase Gene Snapshot Muscle LIM protein at 84B (Mlp84B) encodes a muscle cytoskeletal protein found primarily at the Z-line boundary. It maintains muscle structural integrity and regulates actin bundling. FBgn0000071 Interactive Fly "IG superfamily - ligand for Neurotactin - maintains proper cohesion between axons and contributes to the organization of fascicles - In conjunction with the effector kinase Abl, Ama is necessary for the correct specification of the maxillary identity of NB6-4" FBgn0000439 FlyBase Gene Snapshot Deformed (Dfd) encodes a homeobox-containing transcription factor mainly involved in proper morphological identity of the maxillary segment and the posterior half of the mandibular segment. FBgn0026162 Alliance Predicted to enable AAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0026164 Alliance Predicted to enable AAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0000003 Alliance "Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting." FBgn0001077 FlyBase Gene Snapshot "fushi tarazu (ftz) encodes a HOX-like (HOXL) homeobox transcription factor and is a pair-rule segmentation gene expressed in seven stripes in early embryos. The ftz protein interacts with the obligate partner ftz-f1, a nuclear receptor, to directly activate a set of target genes involved in segment development, including segment polarity genes such as en and ftz itself. ftz is also expressed and required in the developing central nervous system." FBgn0024289 Alliance "Predicted to enable L-iditol 2-dehydrogenase (NAD+) activity. Involved in fructose biosynthetic process and sorbitol catabolic process. Is expressed in several structures, including adult head; adult heart; amnioserosa; dorsal ectoderm anlage; and ectoderm anlage. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase)." FBgn0026563 Alliance Is expressed in adult head and spermatozoon. FBgn0037463 FlyBase Gene Snapshot don juan like (djl) encodes a protein present in spermatids and sperm. FBgn0037464 Alliance Is expressed in spermatozoon. FBgn0037466 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Orthologous to several human genes including PAXBP1 (PAX3 and PAX7 binding protein 1)." FBgn0037468 Alliance Involved in wing disc dorsal/ventral pattern formation. Is expressed in embryonic brain and organism. Used to study congenital heart disease. Orthologous to human JPT1 (Jupiter microtubule associated homolog 1). FBgn0037469 Alliance Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in endomembrane system. Is expressed in adult head and organism. Orthologous to human DCAKD (dephospho-CoA kinase domain containing). FBgn0003884 UniProtKB "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. (UniProtKB:P06603)" FBgn0037470 FlyBase Gene Snapshot "Tailor (Tailor) encodes a cytoplasmic RNA-specific terminal uridylyltransferase. It acts as part of the terminal RNA uridylation-mediated processing (TRUMP) complex, marking RNA species for 3'-to-5' exoribonucleolytic decay by the product of Dis3l2. The product of Tailor regulates microRNA biogenesis by targeting precursor-microRNAs (predominantly mirtron hairpins) and targets unprocessed RNA polymerase III transcripts for degradation in a cytoplasmic RNA surveillance pathway." FBgn0010774 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Located in nuclear membrane and nucleoplasm. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Used to study alcohol use disorder. Orthologous to human ALYREF (Aly/REF export factor). FBgn0037467 UniProtKB E3 UFM1-protein ligase that mediates ufmylation of target proteins. (UniProtKB:Q9VI55) FBgn0037465 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Is expressed in adult head and adult heart. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0003339 FlyBase Gene Snapshot "Sex combs reduced (Scr) is a member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Products of members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. Scr is expressed in the embryonic labial and first thoracic segments. In the absence of its expression the first prothoracic segment is transformed to a second mesothoracic identity and the labial palps to maxillary." FBgn0011904 Alliance Predicted to enable AAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0026163 Alliance Predicted to enable AAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0000166 FlyBase Gene Snapshot bicoid (bcd) encodes a homeodomain-containing transcription factor that forms a concentration gradient to specify the fate map along the anterior-posterior axis of the embryo. FBgn0004053 UniProtKB "Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation. (UniProtKB:P09089)" FBgn0004054 FlyBase Gene Snapshot "zerknullt-related (zen2) encodes a member of the Antennapedia Complex (ANT-C), one of two Hox gene complexes. zen2 is similar in sequence and expression to the adjacent zen gene. The two are closely linked and they appear to be duplicate copies with zen being the ancestral member of the pair. Despite its similarity to zen, absence of zen2 function has no discernible effect on development or morphology." FBgn0037448 Alliance Is expressed in spermatozoon. FBgn0051482 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in adult head. Orthologous to human GLIPR2 (GLI pathogenesis related 2). FBgn0037462 Alliance Predicted to enable calcium ion binding activity. Is expressed in elongation stage spermatid and primary spermatocyte. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). FBgn0051286 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). FBgn0010355 FlyBase Gene Snapshot TBP-associated factor 1 (Taf1) encodes a component of the evolutionarily conserved general transcription factor TFIID. It regulates transcription by binding the initiator element at transcription start sites and binding acetylated histones via its bromodomains. FBgn0004777 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head; adult heart; embryonic foregut; and embryonic/larval tracheal section. FBgn0004780 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Involved in sexual reproduction. Located in extracellular space. FBgn0004783 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in embryonic head epidermis; embryonic/larval midgut; and organism. FBgn0004782 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0004781 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0004779 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head and adult heart. FBgn0004778 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0024912 FlyBase Gene Snapshot O-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. FBgn0026566 UniProtKB The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (UniProtKB:O97067) FBgn0026565 Alliance Predicted to enable argininosuccinate synthase activity. Predicted to be involved in arginine biosynthetic process; argininosuccinate metabolic process; and urea cycle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). FBgn0037461 Alliance Predicted to enable calcium ion binding activity. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). FBgn0037460 Alliance Predicted to enable calcium ion binding activity. Is expressed in elongation stage spermatid and primary spermatocyte. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). FBgn0053202 FlyBase Gene Snapshot defective proboscis extension response 11 (dpr11) encodes a protein involved in axon guidance and regulation of neuromuscular junction development. FBgn0037454 Alliance Orthologous to human IQCD (IQ motif containing D). FBgn0011919 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037429 Alliance Involved in open tracheal system development. Located in endosome membrane. Is expressed in embryonic/larval tracheal dorsal trunk; embryonic/larval tracheal system; and embryonic/larval tracheal transverse connective. FBgn0037430 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in embryonic salivary gland duct; embryonic tracheole; and epithelial tube. FBgn0037431 Alliance Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol. Is expressed in adult thorax and testis. FBgn0037432 Alliance Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol. Is expressed in testis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). FBgn0037433 Alliance Predicted to enable anion binding activity. Involved in response to bacterium and sexual reproduction. Located in extracellular space. Is expressed in adult head and embryonic/larval posterior spiracle. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). FBgn0037435 Alliance Predicted to enable tRNA 2'-O-methyltransferase activity. Predicted to be involved in tRNA methylation. Is expressed in organism. Orthologous to human TRMT13 (tRNA methyltransferase 13 homolog). FBgn0037436 Alliance Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Located in nucleolus. Part of heterochromatin. FBgn0037439 Alliance "Predicted to enable unfolded protein binding activity. Predicted to be involved in protein import into nucleus and ribosomal large subunit biogenesis. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; gland; and nephrocyte. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia. Orthologous to human HEATR3 (HEAT repeat containing 3)." FBgn0010282 UniProtKB TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. (UniProtKB:Q05913) FBgn0037442 FlyBase Gene Snapshot godzilla E3 ubiquitin protein ligase (gzl) encodes a protein that ubiquitylates the SNARE protein encoded by Syb. It also promotes apico-basal transcytosis of the product of wg in the wing imaginal disc. FBgn0037446 FlyBase Gene Snapshot "Zinc-finger protein (Zif) encodes a C2H2-type zinc-finger transcription factor that is required for cell polarity and neuroblast self-renewal by regulating the expression and asymmetric localization of the product of aPKC. The phosphorylated product of Zif by aPKC is excluded from the nucleus, thus being the inactive form." FBgn0037447 UniProtKB Strongly up-regulated in Mhc mutants suggesting a role in muscle function. (UniProtKB:Q9VI25) FBgn0037445 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in organism. Human ortholog(s) of this gene implicated in MHC class II deficiency; autosomal dominant intellectual developmental disorder; and severe combined immunodeficiency. Orthologous to human RFX5 (regulatory factor X5) and RFX7 (regulatory factor X7)." FBgn0037443 FlyBase Gene Snapshot "Transmembrane and coiled-coil domain (Tmcc) encodes a protein that possesses an evolutionarily conserved interaction with members of the Amyloid beta A4 protein family. Co-expression of Tmcc rescues the effect of over-expressing human Amyloid beta A4 protein on development and behavior, and mutation of Tmcc causes aberrant processing of the product of Appl." FBgn0037440 Alliance "Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked. Located in peroxisome. Is expressed in adult brain cell body rind; adult gnathal ganglion; adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase)." FBgn0037512 Alliance Predicted to enable glutathione transmembrane transporter activity. Predicted to be involved in glutathione import into mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to several human genes including SLC25A40 (solute carrier family 25 member 40). FBgn0037515 FlyBase Gene Snapshot Serine protease 7 (Sp7) encodes a hemolymphatic serine protease involved in the activation of the melanization cascade. FBgn0037517 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic Malpighian tubule; embryonic hindgut; embryonic main segment of Malpighian tubule; and embryonic/larval hindgut. Orthologous to human ARRDC1 (arrestin domain containing 1). FBgn0037518 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0051472 FlyBase Gene Snapshot "sugarlethal (sgll) encodes pyridoxine 5'-phosphate oxidase (PNPO). PNPO converts pyridoxine to its active form pyridoxal 5'-phosphate (PLP). PLP is a co-factor required for more than 100 enzymes that function in amino acid metabolism, gluconeogenesis and neurotransmitter synthesis." FBgn0051473 Alliance Predicted to enable pyridoxamine phosphate oxidase activity. Predicted to be involved in pyridoxal phosphate biosynthetic process. FBgn0037526 Alliance "Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial)." FBgn0024909 UniProtKB TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (UniProtKB:Q9VHY5) FBgn0014931 UniProtKB "DNA-binding zinc finger protein that recruits chromo domain protein rhino/rhi to specific chromatin regions enriched in H3K9me2/3 histone methylation, mediating piRNA (piwi-interacting RNA) biogenesis (PubMed:36193674). May bind to GC rich DNA sequences including a 5'-GRGGN-3' sequence motif (PubMed:36193674). Nucleates rhi/rhino accumulation and stabilizes its expansion (PubMed:36193674). Involved in piRNA transposon repression, particularly in the female ovary during oogenesis (PubMed:36193674). (UniProtKB:Q8T053)" FBgn0002542 FlyBase Gene Snapshot lodestar (lds) encodes a protein that belongs to the helicase-related family and is part of the spindle assembly checkpoint engaged in the maintenance of chromosome/genome stability. It is required to load cohesin complexes onto the chromosomes during the embryonic cleavage mitoses. Absence of lds leads to frequent chromosome loss and death of cells and embryos. FBgn0000504 UniProtKB Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. (UniProtKB:P23023) FBgn0037531 Alliance "Predicted to enable ATP hydrolysis activity and ATP-dependent activity, acting on DNA. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in pole plasm and primordial germ cell. Orthologous to human TTF2 (transcription termination factor 2)." FBgn0014930 UniProtKB Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN). (UniProtKB:O76206) FBgn0004901 FlyBase Gene Snapshot "Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes." FBgn0037530 FlyBase Gene Snapshot "ER Membrane protein Complex 1 (EMC1) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins." FBgn0037529 Alliance Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in adult gnathal ganglion; adult head; embryonic/larval midgut; organism; and supraesophageal ganglion. Orthologous to human MRPS9 (mitochondrial ribosomal protein S9). FBgn0037521 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0037520 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. FBgn0037519 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Orthologous to human ARRDC5 (arrestin domain containing 5). FBgn0042101 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Orthologous to human ARRDC5 (arrestin domain containing 5). FBgn0042103 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0042105 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0042102 Alliance Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in extracellular vesicle biogenesis and protein transport. Predicted to be located in extracellular vesicle. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0042104 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). FBgn0037513 FlyBase Gene Snapshot "pyd3 (pyd3) encodes a beta-alanine synthase involved in pyrimidine catabolism, beta-alanine biosynthesis and cuticle pigmentation." FBgn0010401 Alliance Is expressed in Johnston organ; sacculus; and third segment of antenna. FBgn0037535 Alliance Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). FBgn0037536 Alliance Is expressed in adult head and organism. Orthologous to human TMEM245 (transmembrane protein 245). FBgn0037538 Alliance Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in organism. Orthologous to human UBL7 (ubiquitin like 7). FBgn0037540 FlyBase Gene Snapshot "PSEA-binding protein 95kD (Pbp95) encodes a protein that functions as one of three subunits of the small nuclear RNA (snRNA) activating protein complex, which binds as a complex to a proximal sequence element A (PSEA) to activate transcription of snRNA genes." FBgn0037543 Alliance "Predicted to enable rRNA (guanine) methyltransferase activity. Predicted to be involved in rRNA (guanine-N7)-methylation. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor)." FBgn0037546 FlyBase Gene Snapshot "muscarinic Acetylcholine Receptor, B-type (mAChR-B) encodes a G protein-coupled receptor activated by acetylcholine." FBgn0037547 Alliance Predicted to enable acylglycerol lipase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Is expressed in adult head and adult heart. FBgn0037548 Alliance "Predicted to enable acylglycerol lipase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Is expressed in several structures, including adult head; corpus cardiacum; embryonic/larval central nervous system; eye disc; and larval ventral nerve cord. Used to study Parkinson's disease 1." FBgn0037551 UniProtKB "Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618). Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804). In larval motor neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30115618, PubMed:30174114). Acts downstream of Rab2 during presynaptic precursor vesicle biogenesis (PubMed:33822845). Essential role in chromosome segregation (PubMed:15331635). (UniProtKB:Q9VHV5)" FBgn0037552 Alliance "Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species) and TSKU (tsukushi, small leucine rich proteoglycan)." FBgn0037553 Alliance Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be part of voltage-gated potassium channel complex. Is expressed in adult head; adult heart; amnioserosa; and embryonic midgut chamber. FBgn0037554 FlyBase Gene Snapshot DNA polymerase iota (PolI) encodes a protein involved in translesion synthesis. FBgn0040528 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0037556 Alliance Predicted to be involved in negative regulation of macrophage cytokine production. Predicted to be located in nucleoplasm. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human CUEDC2 (CUE domain containing 2). FBgn0001138 FlyBase Gene Snapshot grain (grn) encodes a transcription factor from the GATA family. It regulates the expression of receptors and adhesion molecules such as those encoded by unc-5 and Fas2 involved in axon guidance. It contributes to multiple other developmental processes including leg and larval spiracle morphogenesis. FBgn0011959 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011960 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011961 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011962 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011963 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051583 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037544 Alliance Predicted to be involved in brain development and regulation of mitochondrial ATP synthesis coupled proton transport. Predicted to be located in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human DNAJC30 (DnaJ heat shock protein family (Hsp40) member C30). FBgn0037541 Alliance "Involved in retrograde transport, endosome to Golgi. Predicted to be active in endocytic vesicle. Is expressed in adult head; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human HEATR5A (HEAT repeat containing 5A) and HEATR5B (HEAT repeat containing 5B)." FBgn0001255 Alliance Predicted to be involved in imaginal disc eversion. Predicted to be located in plasma membrane. FBgn0037539 Alliance Predicted to enable ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 80. Orthologous to several human genes including UBAP1 (ubiquitin associated protein 1). FBgn0040524 Alliance Predicted to enable acylphosphatase activity. Orthologous to human ACYP1 (acylphosphatase 1). FBgn0037537 Alliance Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Is expressed in organism. FBgn0037534 UniProtKB Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. (UniProtKB:Q9VHX7) FBgn0037533 FlyBase Gene Snapshot CD98 heavy chain (CD98hc) encodes a transporter involved in the transmembrane import of L-leucine. FBgn0014861 UniProtKB "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. (UniProtKB:P49735)" FBgn0010433 UniProtKB Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection. (UniProtKB:P48987) FBgn0037562 FlyBase Gene Snapshot Nazo (Nazo) encodes a protein with a role in triglyceride homeostasis. Loss of Nazo leads to dramatic decrease in overall lipid levels. FBgn0051463 Alliance Is expressed in embryonic midgut chamber; embryonic/larval midgut; fat body/gonad primordium; and trunk mesoderm. FBgn0037566 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gastric caecum; and gut section. Orthologous to human MRPL1 (mitochondrial ribosomal protein L1)." FBgn0037573 UniProtKB "ATP-dependent RNA helicase (PubMed:22961380). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:22961380). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (PubMed:14973490). (UniProtKB:Q9VHS8)" FBgn0062412 FlyBase Gene Snapshot Copper transporter 1B (Ctr1B) encodes a protein that ensures copper uptake in the intestine. Ctr1B transcription is upregulated under conditions of copper depletion via the metal-responsive transcription factor encoded by MTF-1. FBgn0037576 FlyBase Gene Snapshot Odorant receptor 85a (Or85a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0004908 FlyBase Gene Snapshot ADP ribosylation factor-like 2 (Arl2) encodes a small GTPase within the ADP-ribosylation factor-like family. Arl2 product functions as a central regulator of microtubule growth and asymmetric division of neuroblasts. FBgn0037579 Alliance Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be part of mitochondrial respirasome. Is expressed in adult head and spermatozoon. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1). FBgn0037580 UniProtKB Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues. (UniProtKB:Q9VHR8) FBgn0037581 Alliance Predicted to be involved in cilium organization. Predicted to be active in motile cilium. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human MNS1 (meiosis specific nuclear structural 1). FBgn0020249 FlyBase Gene Snapshot "steamer duck (stck) encodes PINCH, an adapter protein that directly binds and forms a complex with the products of Ilk and ics. PINCH is required for integrin-dependent cell adhesion and signaling." FBgn0037584 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. FBgn0037589 Alliance Predicted to enable diphenyl phthalate binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. FBgn0037583 FlyBase Gene Snapshot Veneno (Veneno) encodes a protein belonging to the TDRD1 family that is predicted to have a role in the piRNA pathway. FBgn0037578 Alliance "Predicted to enable ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; double-stranded DNA binding activity; and polynucleotide 3'-phosphatase activity. Predicted to be involved in DNA repair. Predicted to be located in nucleus. Used to study ataxia-oculomotor apraxia type 4. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2; ataxia-oculomotor apraxia type 4; and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase)." FBgn0040529 UniProtKB "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProtKB:Q9VHS2)" FBgn0003129 FlyBase Gene Snapshot Pox meso (Poxm) encodes a transcription factor that contributes to dendrite morphogenesis and the development and specification of somatic muscle. FBgn0037574 FlyBase Gene Snapshot "Coenzyme Q biosynthesis protein 2 (Coq2) encodes a prenyltransferase that catalyzes the prenylation of p-hydroxybenzoate with the isoprenoid chain in the process of CoQ production. It plays roles in development, CoQ and ATP biosynthesis, and lifespan regulation." FBgn0037569 Alliance "Predicted to be involved in mRNA export from nucleus. Predicted to be part of THO complex part of transcription export complex. Is expressed in several structures, including amnioserosa; dorsal ectoderm; hindgut anlage; inclusive hindgut primordium; and trunk mesoderm. Orthologous to human THOC3 (THO complex subunit 3)." FBgn0037561 UniProtKB Probable ATP-binding RNA helicase. (UniProtKB:Q9VHU1) FBgn0010173 UniProtKB "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (UniProtKB:Q24492)" FBgn0037592 Alliance Predicted to be involved in peroxisome organization. Predicted to be located in peroxisome. Is expressed in adult head and organism. Orthologous to human TMEM135 (transmembrane protein 135). FBgn0051454 Alliance Predicted to be involved in peroxisome organization. Predicted to be located in peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). FBgn0051259 Alliance Predicted to be involved in peroxisome organization. Predicted to be located in peroxisome. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. Orthologous to human TMEM135 (transmembrane protein 135). FBgn0037594 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:Q9VHQ2)" FBgn0051460 UniProtKB "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. (UniProtKB:Q8INQ7)" FBgn0037602 Alliance Predicted to enable mRNA binding activity. Predicted to be active in nucleus. Orthologous to human SLIRP (SRA stem-loop interacting RNA binding protein). FBgn0037603 Alliance Predicted to be involved in Golgi to endosome transport; Golgi to plasma membrane protein transport; and protein localization to Golgi apparatus. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human SYS1 (SYS1 golgi trafficking protein). FBgn0037606 Alliance Predicted to enable polyamine oxidase activity. Is expressed in organism. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to several human genes including PAOX (polyamine oxidase). FBgn0037607 FlyBase Gene Snapshot Transketolase Tkt encodes a putative enzyme that is predicted to catalyze two reversible reactions in the non-oxidative branch of the pentose phosphate pathway. It is predicted to catalyze the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor. FBgn0012024 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012025 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012026 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0000447 FlyBase Gene Snapshot "Dihydroorotate dehydrogenase (Dhod) encodes a protein that is associated with the inner mitochondrial membrane. It catalyzes the fourth step of de novo pyrimidine biosynthesis, which is required for normal cuticle formation and oogenesis." FBgn0024326 FlyBase Gene Snapshot MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability. FBgn0037601 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VHP4) FBgn0012027 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012028 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0026399 FlyBase Gene Snapshot Odorant receptor 85e (Or85e) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0051450 Alliance "Predicted to enable small ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human MRPS18A (mitochondrial ribosomal protein S18A)." FBgn0051453 FlyBase Gene Snapshot pachytene checkpoint 2 (pch2) encodes a protein involved in a checkpoint pathway that monitors the synaptonemal complex assembly and recombination during female meiosis. FBgn0037591 FlyBase Gene Snapshot Odorant receptor 85c (Or85c) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0037590 FlyBase Gene Snapshot Odorant receptor 85b (Or85b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0037608 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; and gut section. Orthologous to human MRPL19 (mitochondrial ribosomal protein L19)." FBgn0037610 Alliance Predicted to enable RNA binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to be active in mitochondrial matrix. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57). FBgn0037611 Alliance "Is expressed in several structures, including antennal primordium; central brain primordium; dorsal pharyngeal muscle cell; head epidermis primordium; and mesoderm. Orthologous to human CDPF1 (cysteine rich DPF motif domain containing 1)." FBgn0037612 Alliance "Predicted to enable O-acyltransferase activity. Predicted to be involved in cholesterol metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including amnioserosa; embryonic/larval hemocyte; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Chagas disease; coronary artery disease; and hepatocellular carcinoma. Orthologous to several human genes including SOAT2 (sterol O-acyltransferase 2)." FBgn0037614 Alliance Predicted to be involved in non-motile cilium assembly. Predicted to be located in cilium. Predicted to be active in ciliary transition zone. Is expressed in organism. Human ortholog(s) of this gene implicated in Joubert syndrome; Joubert syndrome 2; and Meckel syndrome 2. Orthologous to several human genes including TMEM216 (transmembrane protein 216). FBgn0037615 Alliance Predicted to be involved in non-motile cilium assembly. Predicted to be located in cilium. Predicted to be active in ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome; Joubert syndrome 2; and Meckel syndrome 2. Orthologous to several human genes including TMEM216 (transmembrane protein 216). FBgn0037616 Alliance Is expressed in adult head. FBgn0037617 Alliance Enables DNA binding activity. Involved in larval somatic muscle development. Predicted to be located in nucleus. Is expressed in embryonic/larval fat body; organism; and ring gland primordium. FBgn0037618 FlyBase Gene Snapshot ouija board (ouib) encodes a ZAD-C2H2 zinc finger transcription factor essential for ecdysone biosynthesis. It is expressed in the prothoracic gland and stimulates transcription of the ecdysteroidogenic gene spok. FBgn0037619 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism." FBgn0037622 UniProtKB Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. (UniProtKB:Q9VHM2) FBgn0037624 UniProtKB Component of the histone chaperone network (PubMed:36930688). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:36930688). May also bind and stabilize monomeric H3 (PubMed:36930688). Maternal effect gene essential for early embryogenesis (PubMed:36930688). (UniProtKB:Q9I7K6) FBgn0037630 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in larval abdomen. FBgn0037632 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol. Is expressed in adult brain; adult brain cell body rind; adult head; and adult heart. Used to study intrinsic cardiomyopathy and sensory peripheral neuropathy. Orthologous to human CCT7 (chaperonin containing TCP1 subunit 7). FBgn0037634 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and ventral nerve cord primordium." FBgn0040532 Alliance Involved in wing disc dorsal/ventral pattern formation. FBgn0037638 Alliance Predicted to be active in cytosol. Is expressed in adult head and organism. Orthologous to human ARMH3 (armadillo like helical domain containing 3). FBgn0011966 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037637 FlyBase Gene Snapshot Iron-sulfur cluster assembly enzyme (IscU) encodes a ferrous iron binding protein involved in iron-sulfur cluster assembly. FBgn0037633 Alliance Orthologous to human PGBD4 (piggyBac transposable element derived 4). FBgn0037627 Alliance Predicted to be involved in proteolysis. Is expressed in embryonic antennal sense organ; embryonic central brain; embryonic head sensory system; seminal receptacle; and sensory cluster. FBgn0037625 Alliance Is expressed in spermatozoon. FBgn0037621 FlyBase Gene Snapshot Motif 1 Binding Protein (M1BP) encodes a transcription pausing factor. It regulates gene transcription via interaction with the Hox proteins encoded by abd-A and Ubx. It contributes to the development of ovarian follicle cells. FBgn0037620 FlyBase Gene Snapshot ranshi (ranshi) encodes a protein involved in oocyte differentiation. FBgn0037613 FlyBase Gene Snapshot "Cyclin-dependent kinase subunit 85A (Cks85A) encodes a small protein that interacts with the products of Cdk1 and Cdk2. It also functions with the product of Skp2 to target specific substrates for destruction, including the product of dap. It is required for larval growth and to maintain diploidy in imaginal tissues." FBgn0001180 UniProtKB Gap class segmentation protein that controls development of head structures. (UniProtKB:P05084) FBgn0037609 UniProtKB Required for cell surface expression of acetylcholine receptors. (UniProtKB:Q9VHN5) FBgn0037643 FlyBase Gene Snapshot "Succinyl-coenzyme A synthetase beta subunit, ADP-forming (ScsbetaA) encodes a subunit of the ligase that converts succinate to succinyl-CoA in the TCA/Krebs cycle. It contributes to apoptosis and sperm individualization." FBgn0037646 FlyBase Gene Snapshot Carbonic anhydrase beta (CAHbeta) encodes a beta-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons. FBgn0027503 Alliance Predicted to enable protease binding activity. Predicted to be part of Ino80 complex. Orthologous to human NFRKB (nuclear factor related to kappaB binding protein). FBgn0037648 Alliance "Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; autophagy of peroxisome; and macroautophagy. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Orthologous to human WDR45B (WD repeat domain 45B)." FBgn0037650 Alliance Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. FBgn0037652 Alliance "Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut primordium; embryonic/larval muscle system; and gut section. Orthologous to human MYG1 (MYG1 exonuclease)." FBgn0037653 UniProtKB "E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:30503771). Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex (PubMed:30503771). By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing (PubMed:30503771). (UniProtKB:Q9VHI7)" FBgn0037656 Alliance "Predicted to enable single-stranded DNA binding activity. Predicted to be involved in protein-DNA covalent cross-linking repair. Orthologous to human HMCES (5-hydroxymethylcytosine binding, ES cell specific)." FBgn0037657 FlyBase Gene Snapshot hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways. FBgn0037659 UniProtKB "Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (UniProtKB:Q9VHH9)" FBgn0037661 UniProtKB "Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). (UniProtKB:Q9VHH7)" FBgn0037664 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. Is expressed in adult head and embryonic/larval tracheal section. FBgn0037665 FlyBase Gene Snapshot "Sulfotransferase 2 (St2) encodes one out of 4 sulfotransferases that catalyze the sulfonation of many proteins, lipids and glycosaminoglycans." FBgn0037670 Alliance Enables chromatin insulator sequence binding activity; protein heterodimerization activity; and sequence-specific DNA binding activity. Involved in heterochromatin boundary formation. Located in nucleus. Is expressed in head mesoderm; organism; and trunk mesoderm. FBgn0037671 UniProtKB "Multifunctional protein which functions as a transmembrane receptor in the planar cell polarity (PCP) and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump (PubMed:20579879, PubMed:20579883, PubMed:29127204, PubMed:29995586). As transmembrane receptor mediates fz/PCP signaling through interaction with fz and stabilizes asymmetric PCP domains through its interaction with stan (PubMed:20579879, PubMed:20579883, PubMed:23292348, PubMed:29995586). Also mediates Wnt/beta-cat signaling through interaction with fz/fz2 (PubMed:20579879, PubMed:20579883). Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal system, plays a role in many neuronal processes including synapse morphology and synaptic transmission (PubMed:26376863). (UniProtKB:Q9VHG4)" FBgn0010803 FlyBase Gene Snapshot Tryptophanyl-tRNA synthetase (TrpRS) is expressed to high levels in the salivary gland. This could be incidental due to proximity to the salivary gland transcription factor encoded by sage. FBgn0037672 FlyBase Gene Snapshot salivary gland-expressed bHLH (sage) is only expressed in embryonic salivary glands. The product of sage works with the product of fkh to activate expression of salivary gland specific gene products (secreted proteins and enzymes that modify the secreted proteins). FBgn0037669 Alliance "Enables chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in heterochromatin boundary formation and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm." FBgn0037668 Alliance "Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; phosphate ion transmembrane transport; and thiosulfate transport." FBgn0000412 FlyBase Gene Snapshot "D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II." FBgn0003165 FlyBase Gene Snapshot "pumilio (pum) encodes a founding member of the PUF family of RNA binding proteins. It is an essential factor in the translational regulation of hb mRNA in the early embryo. pum product also contributes to multiple processes, including germline stem cell identity maintenance, primordial germ cell proliferation and migration, synaptic plasticity, as well as learning and memory." FBgn0037660 FlyBase Gene Snapshot beag (beag) encodes a spliceosomal protein required for normal neuromuscular junction development and function. It functions together with the product of Smu1 and can regulate the alternative mRNA splicing of Fas2. FBgn0010222 UniProtKB May play a role in spermatogenesis. (UniProtKB:Q04448) FBgn0002932 FlyBase Gene Snapshot "neuralized (neur) encodes an E3 ubiquitin ligase of the RING family. It is part of the Notch signaling pathway, where it is thought to contribute to the endocytosis-dependent activation of the ligand. It also has Notch-independent functions in epithelial morphogenesis." FBgn0040534 FlyBase Gene Snapshot Splicing factor 3b subunit 5 (Sf3b5) encodes a subunit of the histone modifying complex SAGA and the SF3B complex. The latter forms part of the larger U2 snRNP and is required for mRNA splicing. FBgn0037655 UniProtKB Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (UniProtKB:Q95RX5) FBgn0026380 UniProtKB "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:Q9XYN7)" FBgn0051100 Alliance "Predicted to enable transmembrane transporter activity. Involved in glucose transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including Malpighian tubule main body primordium; adult head; dorsal pharyngeal muscle cell; embryonic/larval muscle system; and gut section. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8)." FBgn0037647 FlyBase Gene Snapshot Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of mTor by recruiting it to the lysosome. FBgn0037644 Alliance Predicted to be involved in regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in colorectal cancer; morbid obesity; and primary immunodeficiency disease. Orthologous to human CTNNBL1 (catenin beta like 1). FBgn0037675 FlyBase Gene Snapshot Heterochromatin Protein 1e (HP1e) is a testis-expressed gene required for paternal chromosome segregation during the very first embryonic mitosis. FBgn0037680 FlyBase Gene Snapshot pasiflora 2 (pasi2) encodes a septate junction protein involved in endothelial barrier function. FBgn0037683 Alliance "Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be involved in catabolic process. Is expressed in adult head; embryonic Malpighian tubule; embryonic proventriculus; and embryonic/larval corpus allatum. Orthologous to human PTER (phosphotriesterase related)." FBgn0037684 Alliance Predicted to enable L-serine ammonia-lyase activity; serine racemase activity; and threonine deaminase activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Is expressed in yolk nucleus. Orthologous to human SRR (serine racemase). FBgn0037685 FlyBase Gene Snapshot Odorant receptor 85f (Or85f) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0037687 Alliance Predicted to enable omega-amidase activity. Predicted to be involved in asparagine metabolic process; glutamine metabolic process; and oxaloacetate metabolic process. Is expressed in organism. Orthologous to human NIT2 (nitrilase family member 2). FBgn0037689 Alliance Predicted to be active in membrane. Orthologous to human LMBRD2 (LMBR1 domain containing 2). FBgn0011740 UniProtKB Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). (UniProtKB:Q24451) FBgn0037697 UniProtKB "Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED). (UniProtKB:Q9VHD2)" FBgn0037696 UniProtKB "Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED). (UniProtKB:Q9VHD3)" FBgn0037690 FlyBase Gene Snapshot TWIK-related acid-sensitive K[+] channel 7 (Task7) encodes an ion channel involved in the transmembrane transport of potassium. FBgn0003889 UniProtKB "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. (UniProtKB:P61857)" FBgn0037688 Alliance Predicted to be involved in Golgi organization and Golgi to plasma membrane protein transport. Predicted to be active in Golgi membrane. Orthologous to human BLZF1 (basic leucine zipper nuclear factor 1). FBgn0037686 FlyBase Gene Snapshot Ribosomal protein L34b (RpL34b) encodes a ribosomal structural constituent. FBgn0000723 UniProtKB Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm. (UniProtKB:P18106) FBgn0037679 Alliance Predicted to enable protein serine/threonine kinase activity. Involved in autophagy and positive regulation of autophagosome assembly. Located in autophagosome. Is expressed in organism. Orthologous to human ULK3 (unc-51 like kinase 3). FBgn0037678 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human KLK14 (kallikrein related peptidase 14). FBgn0037677 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human KLK14 (kallikrein related peptidase 14). FBgn0037676 Alliance Is expressed in embryonic brain; embryonic central brain neurons; larval ventral nerve cord; lateral cord neurons; and ventral midline of embryo. FBgn0037700 Alliance "Involved in larval lymph gland hemopoiesis and wing disc dorsal/ventral pattern formation. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval nervous system; and ganglia. Orthologous to human SARNP (SAP domain containing ribonucleoprotein)." FBgn0014022 Alliance Predicted to be involved in maturation of SSU-rRNA. Located in membrane and nucleus. Is expressed in embryonic/larval midgut and organism. FBgn0037703 FlyBase Gene Snapshot "Lysine demethylase 3 (Kdm3) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure." FBgn0037702 Alliance Predicted to enable AP-2 adaptor complex binding activity and phospholipid binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including FCHO2 (FCH and mu domain containing endocytic adaptor 2). FBgn0037707 FlyBase Gene Snapshot RNA-binding protein S1 (RnpS1) encodes a protein involved in RNA splicing and regulation of DNA transposition. FBgn0037709 Alliance "Predicted to enable oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor. Predicted to contribute to 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity and branched-chain alpha-keto acid dehydrogenase activity. Predicted to be involved in branched-chain amino acid catabolic process. Predicted to be part of oxoglutarate dehydrogenase complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval muscle system; and gut section. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha)." FBgn0027950 FlyBase Gene Snapshot Methyl-CpG binding domain protein-like (MBD-like) encodes a protein involved in chromosome condensation and transcription repression. FBgn0037712 Alliance Predicted to enable ATP binding activity and ATP hydrolysis activity. Is expressed in chordotonal neurons; dorsal sensory complex proper primordium; embryonic head sensory system; sensory nervous system primordium; and ventral sensory complex primordium. Orthologous to human IQCA1 (IQ motif containing with AAA domain 1) and IQCA1L (IQ motif containing with AAA domain 1 like). FBgn0037717 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF311 (zinc finger protein 311) and ZNF578 (zinc finger protein 578)." FBgn0037718 Alliance "Predicted to enable misfolded protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in protein folding in endoplasmic reticulum. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3)." FBgn0037720 Alliance "Predicted to be involved in negative regulation of protein phosphorylation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including antennal anlage; central brain anlage; dorsal ectoderm; epithelium; and head epidermis primordium. Orthologous to several human genes including FAM43B (family with sequence similarity 43 member B)." FBgn0037722 Alliance "Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; and germline cell." FBgn0037723 Alliance "Predicted to enable spermidine synthase activity. Predicted to be involved in spermidine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human SRM (spermidine synthase)." FBgn0012344 Interactive Fly hormone produced by brain neurosecretory cells - sensor of nutritive sugar - directs the detection and consumption of nutritive sugar - controls sperm retention and storage by females - a circadian output hormone that is required for normal rest:activity rhythms FBgn0037727 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0037728 Alliance Predicted to enable Hsp90 protein binding activity; prostaglandin-E synthase activity; and protein-folding chaperone binding activity. Involved in RISC complex assembly. Located in endoplasmic reticulum and nuclear membrane. Is expressed in adult head. Orthologous to several human genes including PTGES3 (prostaglandin E synthase 3). FBgn0028997 Alliance Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside triphosphate biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in centrosome. Is expressed in adult head and spermatozoon. Orthologous to human NME7 (NME/NM23 family member 7). FBgn0037731 Alliance Predicted to enable N-acetyltransferase activity. Is expressed in adult head. FBgn0052939 Alliance Is expressed in adult head. FBgn0003886 FlyBase Gene Snapshot alpha-Tubulin at 85E (alphaTub85E) encodes the major alpha-Tubulin constituent of accessory and attachment cells of chordotonal organs. FBgn0002431 FlyBase Gene Snapshot "hyperplastic discs (hyd) encodes a ubiquitin ligase that is required for Wg signal response in wing discs. It catalyzes the ubiquitylation of the transcriptional co-repressor encoded by gro, which in turn enables the transcription of Wnt targets." FBgn0037734 FlyBase Gene Snapshot trabid (trbd) encodes a OTU family member that interacts with the product of Apc when ubiquitinated. It affects the activity of the product of Apc in transcription. FBgn0051352 FlyBase Gene Snapshot Uncoordinated 115a (Unc-115a) encodes a protein involved in axon pathfinding in the visual system and the CNS. FBgn0053105 FlyBase Gene Snapshot p24-related-2 (p24-2) encodes a p24-transporter-type protein involved in post-mating oviposition. FBgn0260463 Alliance "Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Located in nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult head; brain; embryonic hindgut; and epithelium. Orthologous to human ABLIM1 (actin binding LIM protein 1); ABLIM2 (actin binding LIM protein family member 2); and ABLIM3 (actin binding LIM protein family member 3)." FBgn0069242 UniProtKB "Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected. Involved in Golgi organization. (UniProtKB:Q9I7K5)" FBgn0037730 Alliance "Predicted to enable dipeptide transmembrane transporter activity. Predicted to be involved in dipeptide import across plasma membrane. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval fat body; embryonic/larval midgut; and epithelium. Orthologous to human SLC15A2 (solute carrier family 15 member 2)." FBgn0037724 FlyBase Gene Snapshot Frost (Fst) encodes a potentially secreted protein that protects female reproduction after cold treatment. FBgn0003334 UniProtKB "Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. (UniProtKB:Q9VHA0)" FBgn0005585 FlyBase Gene Snapshot "Calreticulin (Calr) encodes a protein that contributes to olfactory behavior, central nervous system development and sleep. It also works as a marker for phagocytosis of apoptotic cells by phagocytes in embryonic stages." FBgn0037721 Alliance Predicted to enable oxidoreductase activity. Is expressed in adult head; embryonic large intestine; and eye. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase). FBgn0027338 FlyBase Gene Snapshot karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N. FBgn0037715 Alliance Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; adult heart; and organism. Used to study intestinal cancer. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). FBgn0037714 Alliance Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). FBgn0037713 UniProtKB "3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. (UniProtKB:Q9VHB3)" FBgn0037710 UniProtKB Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). (UniProtKB:Q9VHB6) FBgn0024833 FlyBase Gene Snapshot "Adaptor Protein complex 1, mu subunit (AP-1mu) encodes a clathrin adaptor involved in intracellular transport. It controls the trafficking of proteins, including the products of N and spdo." FBgn0037708 UniProtKB Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. (UniProtKB:Q9VHB9) FBgn0037705 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in behavioral response to ethanol and long-term memory. Predicted to be located in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; larval ventral nerve cord; organism; and posterior midgut primordium. Orthologous to human RNF38 (ring finger protein 38) and RNF44 (ring finger protein 44). FBgn0000244 FlyBase Gene Snapshot "blistery (by) encodes fly tensin, an adaptor protein that can bind integrins and actin and colocalizes with integrins in numerous tissues. Null alleles have a mild defect in integrin adhesion, as they are adult viable with loss of adhesion between the wing epithelia." FBgn0014023 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrial ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Orthologous to human MRPL47 (mitochondrial ribosomal protein L47). FBgn0003205 FlyBase Gene Snapshot "Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively." FBgn0014380 UniProtKB Essential for the maturation of hemocytes. (UniProtKB:Q24192) FBgn0037698 Alliance Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein); TRERF1 (transcriptional regulating factor 1); and ZNF541 (zinc finger protein 541). FBgn0037737 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in dorsal pharyngeal muscle primordium; head visceral muscle primordium; organism; somatic muscle primordium; and visceral muscle primordium. Orthologous to human PNN (pinin, desmosome associated protein)." FBgn0051415 Alliance Is expressed in spermatozoon. FBgn0005777 FlyBase Gene Snapshot Protein phosphatase D3 (PpD3) encodes a protein required for mitosis. FBgn0037743 UniProtKB "Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol. (UniProtKB:Q9VH78)" FBgn0037751 UniProtKB Required for male meiotic division and spermatid differentiation. Required for accumulation of aly and comr on chromatin. May function as a transcription factor. (UniProtKB:Q9VH70) FBgn0037754 Alliance Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including DIRAS2 (DIRAS family GTPase 2). FBgn0037756 Alliance Predicted to enable heparin binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in regulation of receptor-mediated endocytosis. Located in endomembrane system. Is expressed in adult head; germline cell; organism; pole plasm; and primordial germ cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). FBgn0037757 Alliance Is expressed in adult head. FBgn0037759 Alliance "Predicted to enable asparaginase activity. Predicted to be involved in amino acid metabolic process. Is expressed in several structures, including adult head; central brain primordium; larval ventral nerve cord; longitudinal visceral muscle primordium; and mesoderm. Orthologous to human ASPG (asparaginase)." FBgn0037761 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0037762 FlyBase Gene Snapshot "elongase F (eloF) encodes a transmembrane fatty acid elongase, utilizing saturated and unsaturated LCFAs to synthesize VLCFAs (up to C30), that contributes to the synthesis of female pheromone precursors." FBgn0037770 UniProtKB Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling. Coordinates ecdysone-mediated expression of cell death genes. (UniProtKB:Q9VH48) FBgn0037766 FlyBase Gene Snapshot tipE homolog 1 (Teh1) encodes a protein involved in regulation of sodium transport. FBgn0037765 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult fat body; adult head; and adult heart. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0037763 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; adult heart; and organism. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0037760 FlyBase Gene Snapshot F-box protein 11 (FBXO11) encodes a subunit of a SCF-like E3 ubiquitin ligase involved in gene silencing mediated by both siRNAs and miRNAs.s FBgn0037758 Alliance "Predicted to enable oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Predicted to be involved in protein homooligomerization. Is expressed in anterior endoderm; anterior midgut primordium; organism; posterior endoderm; and posterior midgut primordium. Orthologous to human SHKBP1 (SH3KBP1 binding protein 1) and KCTD3 (potassium channel tetramerization domain containing 3)." FBgn0037755 Alliance Located in endomembrane system. Is expressed in adult head and organism. FBgn0002868 FlyBase Gene Snapshot Metallothionein A (MtnA) encodes a member of the Metallothionein family whose transcript level is higher than that of the other four Drosophila metallothioneins. Transcription is strongly induced by copper and cadmium ions and this induction depends on the transcription factor encoded by MTF-1. FBgn0037750 FlyBase Gene Snapshot "WHAMM and JMY related (Whamy) encodes a Rac GTPase binding protein that promotes fast actin filament elongation. It is involved in cell migration, microtubule bundle formation and myoblast fusion." FBgn0037749 Alliance Predicted to enable biliverdin reductase [NAD(P)+] activity and riboflavin reductase (NADPH) activity. Involved in sexual reproduction. Is expressed in adult head. Orthologous to human BLVRB (biliverdin reductase B). FBgn0024330 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q8MSX2)" FBgn0037742 Alliance "Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in central brain primordium; embryonic brain; fat body/gonad primordium; gonad; and organism. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4)." FBgn0037741 Alliance Predicted to be active in cytoplasm. Orthologous to human TTI1 (TELO2 interacting protein 1). FBgn0037739 Alliance Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; germline cell; organism; and primordial germ cell. Orthologous to human C14orf119 (chromosome 14 open reading frame 119). FBgn0037736 Alliance "Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval midgut; embryonic/larval nervous system; and ganglia." FBgn0037772 Alliance "Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); HMSD (histocompatibility minor serpin domain containing); and SERPINH1 (serpin family H member 1)." FBgn0027524 Alliance Predicted to be part of Cdc73/Paf1 complex. Is expressed in adult head and organism. Orthologous to human SKIC8 (SKI8 subunit of superkiller complex). FBgn0037778 UniProtKB Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Also regulates mitochondrial DNA copy number. Stimulates transcription independently of the methyltransferase activity. (UniProtKB:Q9VH38) FBgn0037780 FlyBase Gene Snapshot ohgata (ohgt) encodes a protein that controls growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in third-instar neuromuscular junction synapses. FBgn0051410 FlyBase Gene Snapshot "Niemann-Pick type C-2e (Npc2e) encodes a protein involved in the immune signaling pathway via interaction with lipopolysaccharide, lipid A, peptidoglycan and lipoteichoic acid." FBgn0037783 Alliance Predicted to enable sterol binding activity. Predicted to be involved in sterol transport. FBgn0041105 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in central brain primordium and embryonic brain. Orthologous to human INSM1 (INSM transcriptional repressor 1) and INSM2 (INSM transcriptional repressor 2)." FBgn0037788 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; cuboidal/columnar epithelium; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12). FBgn0051477 Alliance "Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis and proton transmembrane transport. Predicted to be part of mitochondrial proton-transporting ATP synthase, central stalk. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to human ATP5F1E (ATP synthase F1 subunit epsilon) and ATP5F1EP2 (ATP synthase F1 subunit epsilon pseudogene 2)." FBgn0037796 Alliance "Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval midgut; gland; and larval ventral nerve cord." FBgn0040238 FlyBase Gene Snapshot "Bestrophin 1 (Best1) encodes a Ca-activated Cl channel. In Drosophila S2 cells, the current of the product of Best1 is activated by calcium and by cell swelling and plays a role in cell volume regulation." FBgn0037794 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). FBgn0037792 FlyBase Gene Snapshot TATA box-binding protein-associated factor RNA polymerase I subunit B (TAF1B) encodes a protein that associates with the products of TAF1C-like and udd. It helps to regulate pre-rRNA transcription. FBgn0004889 FlyBase Gene Snapshot twins (tws) encodes a regulatory subunit of protein phosphatase 2A (PP2A) and is involved in many developmental processes and signaling pathways. FBgn0001321 FlyBase Gene Snapshot "knickkopf (knk) encodes a GPI-anchorded protein, needed for chitin organisation in the cuticle and the tracheal system (tracheal cuticle, tube diameter regulation & gas filling)." FBgn0028734 FlyBase Gene Snapshot "Fmr1 (Fmr1) encodes an RNA and channel binding protein. It acts as a neural growth brake regulating RNA trafficking, RNA translation and neuronal excitability. Fmr1 loss causes Fragile X syndrome." FBgn0037786 Alliance Predicted to enable alkaline phosphatase activity. Is expressed in adult head; wing hinge primordium; and wing pouch. FBgn0037782 Alliance Predicted to enable sterol binding activity. Predicted to be involved in sterol transport. Is expressed in embryonic/larval salivary gland. FBgn0037781 FlyBase Gene Snapshot "Fancl (Fancl) encodes a member of the Fanconi anemia pathway, which is a key mediator of DNA damage repair through homologous recombination. When mono-ubiquinated by the Fanconi core complex, it associates with the product of Fancd2 and localizes to sites of DNA damage." FBgn0037777 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Used to study nuclear type mitochondrial complex I deficiency 15. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 15. Orthologous to human NDUFAF4 (NADH:ubiquinone oxidoreductase complex assembly factor 4). FBgn0053208 FlyBase Gene Snapshot "Molecule interacting with CasL (Mical) encodes a multi-domain flavoprotein monooxygenase (Redox) enzyme. It is activated by actin filaments, and then oxidizes actin on methionines 44 and 47, disassembling the actin filaments and inhibiting actin polymerization. This regulates cell morphology in the nervous system and muscle, working with the the receptor encoded by PlexA and cofilin, encoded by tsr." FBgn0051407 Alliance Is expressed in adult heart. FBgn0037773 Alliance "Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including antenno-maxillary complex; central brain primordium; ganglia; sensory nervous system primordium; and sensory organ cell. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B)." FBgn0045473 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8INM9)" FBgn0037797 Alliance "Is expressed in several structures, including amnioserosa anlage; antennal anlage; antennal primordium; anterior endoderm anlage; and head epidermis primordium." FBgn0037801 Alliance Predicted to enable glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and pyridoxal phosphate binding activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval fat body; fat body/gonad primordium; and yolk nucleus. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GLDC (glycine decarboxylase). FBgn0040078 FlyBase Gene Snapshot "pontin (pont) encodes a member of the AAA+ (ATPases Associated with various cellular Activities) family. It is found in different complexes involved in transcriptional regulation, chromatin remodelling, DNA repair or ribonucleoprotein assembly, and participates in the control of cell proliferation and survival." FBgn0037809 Alliance Is expressed in adult heart. Orthologous to human LENG1 (leukocyte receptor cluster member 1). FBgn0037810 FlyBase Gene Snapshot slender lobes (sle) encodes a component of the nucleolus. sle depletion alters the aggregation of nucleolar components and results in retardation of proliferation of Kenyon cells. FBgn0037811 Alliance "Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative." FBgn0051406 Alliance Involved in notum morphogenesis. FBgn0015396 FlyBase Gene Snapshot "jumeau (jumu) encodes a multi-functional transcription factor that acts upstream of a Polo-kinase dependent pathway in one report. Its roles include asymmetric protein localization, chromatin modification, dendrite formation and organ (eye, wing and bristle) development." FBgn0020379 FlyBase Gene Snapshot Rfx (Rfx) encodes a transcription factor involved in the differentiation of ciliated sensory neurons. FBgn0037807 Alliance Predicted to enable L-ascorbate:sodium symporter activity. Predicted to be involved in L-ascorbic acid transmembrane transport. Predicted to be located in plasma membrane. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to human SLC23A1 (solute carrier family 23 member 1) and SLC23A2 (solute carrier family 23 member 2). FBgn0011970 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037802 FlyBase Gene Snapshot Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. FBgn0037798 Alliance Predicted to enable calcium ion binding activity. Is expressed in embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. FBgn0025879 FlyBase Gene Snapshot "Tissue inhibitor of metalloproteases (Timp) encodes a member of a family of proteins that are able to block access to the catalytic domain of matrix metalloproteinases, thus regulating extracellular matrix remodelling." FBgn0045443 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in amnioproctodeal invagination; cephalic furrow; and mesoderm. FBgn0037815 FlyBase Gene Snapshot Rrp46 (Rrp46) encodes a protein involved in gene expression regulation. FBgn0037817 Alliance "Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1)." FBgn0037816 UniProtKB Potential regulator of CDK5 activity. (UniProtKB:Q9VGZ1) FBgn0024957 FlyBase Gene Snapshot Iron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A. FBgn0037814 Alliance Predicted to be involved in protein ubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in organism. Orthologous to human DCAF15 (DDB1 and CUL4 associated factor 15). FBgn0037831 FlyBase Gene Snapshot Chromosome associated protein H2 (Cap-H2) encodes a condensin protein involved in chromatin organization and chromosome segregation. FBgn0037832 Alliance "Predicted to enable PDZ domain binding activity and SH2 domain binding activity. Involved in response to desiccation and sensory perception of taste. Located in apical part of cell. Is expressed in several structures, including assembly zone; embryonic/larval integumentary system; embryonic/larval mouth; epidermis; and sense organ." FBgn0017577 FlyBase Gene Snapshot Minichromosome maintenance 5 (Mcm5) encodes a protein that is involved in mitotic DNA replication and is required to resolve meiotic double-strand breaks into crossovers. FBgn0037835 Alliance "Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; embryonic/larval muscle system; somatic muscle primordium; and visceral mesoderm derivative." FBgn0037838 Alliance "Predicted to enable tubulin-glutamic acid ligase activity. Predicted to be involved in protein modification process. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval posterior spiracle; and gut section." FBgn0037841 Alliance Predicted to enable histone H3K36 dimethyltransferase activity. Predicted to be located in nucleus. Is expressed in anterior midgut primordium; organism; and posterior midgut primordium. Orthologous to human SETMAR (SET domain and mariner transposase fusion gene). FBgn0037843 Alliance "Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal head epidermis; dorsal pharyngeal muscle primordium; embryonic/larval midgut; embryonic/larval muscle cell; and embryonic/larval salivary gland. Orthologous to human TXNDC9 (thioredoxin domain containing 9)." FBgn0037844 Alliance Predicted to enable nucleic acid binding activity. Is expressed in organism and wing disc. FBgn0037848 FlyBase Gene Snapshot "Tetraspanin 86D (Tsp86D) encodes a member of the tetraspanin superfamily. With two other tetraspanins, encoded by Tsp3A and Tsp26A, it regulates the trafficking of the product of kuz and consequently Notch signaling and several Notch-dependent developmental processes." FBgn0037849 Alliance Is expressed in embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and ventral midline of embryo. Orthologous to human TMEM169 (transmembrane protein 169). FBgn0011768 FlyBase Gene Snapshot "Formaldehyde dehydrogenase (Fdh) encodes a medium-chain alcohol dehydrogenase. This enzyme also functions as S-nitrosoglutathione reductase during the nitric oxide metabolism, contributing to visual memory." FBgn0037846 Alliance "Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; biotin-responsive basal ganglia disease; cleft lip; dextro-looped transposition of the great arteries; and megaloblastic anemia. Orthologous to several human genes including SLC19A1 (solute carrier family 19 member 1) and SLC19A2 (solute carrier family 19 member 2)." FBgn0037845 Alliance "Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; biotin-responsive basal ganglia disease; cleft lip; dextro-looped transposition of the great arteries; and megaloblastic anemia. Orthologous to several human genes including SLC19A1 (solute carrier family 19 member 1) and SLC19A2 (solute carrier family 19 member 2)." FBgn0037842 Alliance Enables serine hydrolase activity. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human LYPLAL1 (lysophospholipase like 1). FBgn0037837 Alliance Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). FBgn0037834 Alliance Enables nuclear receptor corepressor activity and protein-arginine N-methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in adult heart; organism; and ovary. Orthologous to several human genes including PRMT8 (protein arginine methyltransferase 8). FBgn0010421 UniProtKB TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. (UniProtKB:P41900) FBgn0051390 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9GYV9)" FBgn0051272 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in lipid metabolic process and transmembrane transport. Predicted to be active in membrane. Is expressed in Malpighian tubule primordium; adult Malpighian tubule principal cell; adult head; and embryonic Malpighian tubule. Orthologous to human SVOPL (SVOP like). FBgn0037829 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human SVOPL (SVOP like). FBgn0004841 UniProtKB Receptor for tachykinin-like peptides. (UniProtKB:P30974) FBgn0037828 Alliance Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Predicted to be part of mitochondrial outer membrane translocase complex. Is expressed in elongation stage spermatid; germline cell; primary spermatocyte; spermatid; and testis. Used to study cancer. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20). FBgn0037826 Alliance Predicted to enable phosphatase binding activity. Orthologous to human PPP1R36 (protein phosphatase 1 regulatory subunit 36). FBgn0051373 Alliance "Predicted to enable peptide deformylase activity. Predicted to be involved in co-translational protein modification. Predicted to be active in mitochondrion. Orthologous to human PDF (peptide deformylase, mitochondrial)." FBgn0051278 Alliance "Predicted to enable peptide deformylase activity. Predicted to be involved in co-translational protein modification. Predicted to be active in mitochondrion. Orthologous to human PDF (peptide deformylase, mitochondrial)." FBgn0051467 Alliance Predicted to enable phosphatase binding activity. Orthologous to human PPP1R36 (protein phosphatase 1 regulatory subunit 36). FBgn0051391 Alliance Predicted to enable phosphatase binding activity. Is expressed in spermatozoon. Orthologous to human PPP1R36 (protein phosphatase 1 regulatory subunit 36). FBgn0037819 Alliance Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. Is expressed in adult glial cell; mesoderm anlage; and organism. Orthologous to human PHYHD1 (phytanoyl-CoA dioxygenase domain containing 1). FBgn0037818 Alliance "Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; foregut primordium; posterior endoderm; and proventriculus primordium. Orthologous to human ACY1 (aminoacylase 1)." FBgn0037856 FlyBase Gene Snapshot "Leash (Leash) encodes a member of the arrestin domain-containing protein family, which functions as an adaptor molecule for protein degradation. It inhibits growth by inducing degradation of the product of yki via the lysosomal pathway." FBgn0037857 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human ENDOG (endonuclease G). FBgn0037855 Alliance Orthologous to human TTC14 (tetratricopeptide repeat domain 14). FBgn0042094 Alliance Enables adenylate kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and nucleoside triphosphate biosynthetic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to several human genes including AK3 (adenylate kinase 3). FBgn0037853 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Is expressed in adult fat body and organism. Orthologous to human ARRDC5 (arrestin domain containing 5). FBgn0037852 FlyBase Gene Snapshot "Thiamine pyrophosphate carrier protein 1 (Tpc1) encodes an important protein for mitochondrial metabolism located at the inner mitochondrial membrane. Its main role is to import thiamine pyrophosphate (ThPP) into mitochondria. ThPP is an essential coenzyme for the E1 components of pyruvate dehydrogenase and oxoglutarate dehydrogenase, which are located in the mitochondrial matrix." FBgn0037862 Alliance "Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic/larval midgut; organism; spermatozoon; and testis. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2)." FBgn0040257 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0040259 Alliance Predicted to enable UDP-glycosyltransferase activity. Located in endomembrane system. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to several human genes including UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). FBgn0027584 Alliance Enables serine hydrolase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0040252 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0037874 FlyBase Gene Snapshot Translationally controlled tumor protein (Tctp) encodes a protein that belongs to the TCTP family. It interacts with the GTPase encoded by Rheb to regulate organ growth. It is required for DNA damage response and genome stability. FBgn0037876 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; head mesoderm; larval ventral nerve cord; organism; and trunk mesoderm. FBgn0020910 UniProtKB The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (UniProtKB:O16797) FBgn0037879 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in adult head. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0037880 UniProtKB Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (UniProtKB:Q9VGR2) FBgn0037883 UniProtKB "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph1 and Dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising Dph3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in Dph1-Dph2 keeping the (UniProtKB:Q9VGQ9)" FBgn0037885 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. FBgn0051441 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF784 (zinc finger protein 784)." FBgn0051388 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human ZNF707 (zinc finger protein 707) and ZNF746 (zinc finger protein 746). FBgn0037889 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0037891 Alliance Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity. Involved in cellular respiration. Located in Z disc. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). FBgn0037890 Alliance "Involved in behavioral response to ethanol. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; germline cell; and gonad." FBgn0037888 Alliance Predicted to be located in extracellular region. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0037884 FlyBase Gene Snapshot Arfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development. FBgn0037882 Alliance Predicted to enable nucleic acid binding activity. Predicted to be involved in spliceosomal complex disassembly. Part of precatalytic spliceosome. Orthologous to human DNAJC17 (DnaJ heat shock protein family (Hsp40) member C17). FBgn0037881 FlyBase Gene Snapshot "GRIP and coiled-coil domain containing 88 kDa (GCC88) encodes a member of the Golgin family. It associates with Arl1, an Arf-like GTPase and Rab GTPases. It localizes to the trans-Golgi where it may be involved in vesicle-mediated transport or maintaining Golgi architecture." FBgn0037878 Alliance "Predicted to enable heat shock protein binding activity. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including CNS glial cell; adult head; antennal anlage; ganglia; and head epidermis primordium. Orthologous to human DNAJC9 (DnaJ heat shock protein family (Hsp40) member C9)." FBgn0037877 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval somatic muscle cell; embryonic/larval visceral muscle cell; organism; and visceral muscle primordium." FBgn0037875 FlyBase Gene Snapshot Zinc transporter 86D (ZnT86D) encodes a transporter involved in zinc detoxification. FBgn0037873 FlyBase Gene Snapshot "Succinate dehydrogenase, subunit C (SdhC) encodes a protein involved in mitochondrial electron transport and oxidative stress response." FBgn0040250 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0026315 Alliance "Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; leg; and third segment of antenna. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0026314 Alliance "Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is expressed in adult head; leg; and third segment of antenna. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0040255 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0040253 Alliance Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to several human genes including UGT1A6 (UDP glucuronosyltransferase family 1 member A6) and UGT2A3 (UDP glucuronosyltransferase family 2 member A3). FBgn0040251 FlyBase Gene Snapshot UDP-glycosyltransferase family 302 member K1 (Ugt302K1) encodes a UDP-glucosyltransferase. FBgn0040256 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A3 (UDP glucuronosyltransferase family 1 member A3); UGT1A4 (UDP glucuronosyltransferase family 1 member A4); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8)." FBgn0037860 Alliance "Predicted to enable electron transfer activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in adult head; spermatozoon; and testis. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C)." FBgn0037892 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle system. Used to study DiGeorge syndrome. Orthologous to human MRPL40 (mitochondrial ribosomal protein L40)." FBgn0011774 FlyBase Gene Snapshot "Inverted repeat-binding protein (Irbp) encodes a protein that, together with the product of Ku80, forms part of the Ku protein complex, which is involved in double-strand break repair via non-homologous end joining and telomere maintenance." FBgn0037894 UniProtKB "Nuclear transport receptor that mediates nuclear import of proteins (PubMed:33632744). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (By similarity). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity). Mediates the import of pre-assembled proteasomes into the nucleus during the late stages of sperm development (PubMed:33632744). (UniProtKB:Q9VGP4)" FBgn0037897 Alliance "Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in autophagy. Predicted to be active in centrosome and midbody. Is expressed in several structures, including adult midgut progenitor cell; amnioserosa; embryonic/larval midgut; spermatozoon; and yolk nucleus. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26)." FBgn0037898 UniProtKB "An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426). Deacylates mischarged endogenous and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (PubMed:28362257). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity). (UniProtKB:Q9VGP0)" FBgn0037900 Alliance Enables ADP phosphatase activity and ATP hydrolysis activity. Predicted to be involved in proteoglycan biosynthetic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Orthologous to human CANT1 (calcium activated nucleotidase 1). FBgn0037902 Alliance Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in nucleotide-sugar transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC35G1 (solute carrier family 35 member G1). FBgn0046225 Alliance Predicted to be involved in apoptotic process. Predicted to be active in keratin filament. Is expressed in chordotonal neurons; organism; and spermatogonium. Orthologous to human TCHP (trichoplein keratin filament binding). FBgn0037908 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. FBgn0037906 FlyBase Gene Snapshot "Peptidoglycan recognition protein LB (PGRP-LB) encodes a secreted protein with an amidase activity that scavenges DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It negatively regulates the immune deficiency pathway." FBgn0051374 FlyBase Gene Snapshot sarcomere length short (sals) encodes an actin binding protein that promotes sarcomeric actin filament elongation from pointed ends during muscle growth. FBgn0037901 UniProtKB 3'-5' exoribonuclease required for mitochondrial metabolism. (UniProtKB:Q9VGN7) FBgn0037899 UniProtKB Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity). (UniProtKB:Q9VGN9) FBgn0037896 FlyBase Gene Snapshot "ninaG (ninaG) encodes a glucose-methanol-choline oxidoreductase required for the biogenesis of the rhodopsin chromophore (3S)-3-hydroxyretinal, likely by stimulating conversion between the two enantiomers of 3-hydroxyretinal." FBgn0037895 Alliance Enables solute:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and lateral cord. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0026064 Alliance Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to be active in cytoplasm. FBgn0026063 Alliance Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in mesoderm. FBgn0037911 Alliance Predicted to enable 8-oxo-GDP phosphatase activity and 8-oxo-dGDP phosphatase activity. Orthologous to human NUDT18 (nudix hydrolase 18). FBgn0037916 Alliance Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). FBgn0037917 FlyBase Gene Snapshot whacked (wkd) encodes a RabGAP that catalyzes the GTPase activity of its Rab-GTP partners. Its essential substrate appears to be the product of Rab35. wkd mutations are associated with seamless tube defects in the tracheal system. FBgn0037920 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. FBgn0037922 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in antennal anlage in statu nascendi; central brain anlage in statu nascendi; dorsal head epidermis anlage in statu nascendi; organism; and visual anlage in statu nascendi. FBgn0042205 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism." FBgn0037924 Alliance "Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. Is expressed in several structures, including adult fat body; adult head; central brain primordium; ganglia; and gut section." FBgn0037926 UniProtKB "Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:36302967). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:36302967). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). Binding by the elongator complex stabilizes microtubules and promotes their growth (PubMed:36302967). This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells (PubMed:36302967). Involved in protein synthesis-dependent long-term memory formation, probably as part of the elongator complex (PubMed:29545390). (UniProtKB:Q9VGK7)" FBgn0037930 Alliance "Predicted to enable FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and visceral mesoderm derivative. Orthologous to human FKBP2 (FKBP prolyl isomerase 2)." FBgn0037933 FlyBase Gene Snapshot Heme oxygenase (Ho) encodes a heme oxygenase involved in heme metabolism. FBgn0037939 Alliance Predicted to enable mRNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in connective tissue cancer (multiple); essential tremor 4; and neurodegenerative disease (multiple). Orthologous to human FUS (FUS RNA binding protein) and TAF15 (TATA-box binding protein associated factor 15). FBgn0025821 FlyBase Gene Snapshot inhibitor-t (I-t) encodes a protein phosphatase inhibitor. FBgn0037942 Alliance "Predicted to enable thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1)." FBgn0037943 Alliance "Involved in defense response to Gram-negative bacterium. Is expressed in several structures, including antennal primordium; anterior endoderm; central brain primordium; embryonic/larval midgut primordium; and head epidermis primordium. Orthologous to human WDR55 (WD repeat domain 55)." FBgn0037944 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be active in cytosol. Is expressed in wing hinge primordium and wing pouch. Orthologous to human RNF111 (ring finger protein 111). FBgn0002906 FlyBase Gene Snapshot "Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination." FBgn0037937 FlyBase Gene Snapshot 48 related 3 (Fer3) encodes a basic helix-loop-helix (bHLH) transcription factor expressed in the ventral nerve cord. FBgn0042110 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0037936 Alliance Predicted to enable ecdysteroid 22-kinase activity. Involved in copper ion homeostasis. FBgn0037935 Alliance Enables myosin binding activity. Is expressed in adult head and spermatozoon. FBgn0037934 Alliance "Predicted to enable ecdysteroid 22-kinase activity. Is expressed in several structures, including adult head; amnioserosa; anterior endoderm; embryonic/larval midgut; and embryonic/larval midgut primordium." FBgn0011290 FlyBase Gene Snapshot "TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex." FBgn0037931 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to several human genes including ZNF721 (zinc finger protein 721)." FBgn0037923 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism." FBgn0037921 Alliance Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. FBgn0051363 FlyBase Gene Snapshot Jupiter (Jupiter) encodes a microtubule-associated protein. Jupiter-labeled microtubules move through the nurse cell-oocyte ring canals in stage 9 egg chambers. FBgn0037918 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; antennal primordium; central brain primordium; ganglia; and head epidermis primordium." FBgn0037915 Alliance Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). FBgn0037950 FlyBase Gene Snapshot Histamine-gated chloride channel subunit 1 (HisCl1) encodes an ion transmembrane transport complex subunit that contributes to thermotaxis and chloride transport. FBgn0019624 UniProtKB "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProtKB:Q94514)" FBgn0003312 FlyBase Gene Snapshot "shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle." FBgn0051368 Interactive Fly "a helicase - a component of the NineTeen Complex (NTC), also known as Pre-mRNA-processing factor 19 (Prp19) complex - regulates distinct spliceosome conformational changes necessary for splicing, rate-limiting for splicing of a subset of small first introns during oogenesis, including the first intron of gurken" FBgn0051211 Alliance Predicted to be active in nuclear speck and presynaptic active zone. Orthologous to human PNISR (PNN interacting serine and arginine rich protein). FBgn0013276 FlyBase Gene Snapshot Heat-shock-protein-70Ab (Hsp70Ab) encodes a protein involved in response to heat shock and hypoxia. FBgn0000147 FlyBase Gene Snapshot "aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation." FBgn0037970 FlyBase Gene Snapshot Glutamate Carrier 2 (GC2) encodes a protein of the inner mitochondrial membrane that catalyzes the transport of L-glutamate across the inner mitochondrial membrane. GC2 expression is confined to the testes. FBgn0037976 UniProtKB "Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions (PubMed:10801863). Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males (PubMed:26083710). The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which leads to courtship suppression through release of tachykinin from a cluster of 8-10 neurons in the SEZ (PubMed:26083710). (UniProtKB:Q9VGE8)" FBgn0037975 Alliance "Predicted to enable D-arabinose 1-dehydrogenase [NAD(P)+] activity. Predicted to be involved in dehydro-D-arabinono-1,4-lactone biosynthetic process." FBgn0037974 Alliance "Predicted to enable D-arabinose 1-dehydrogenase [NAD(P)+] activity. Predicted to be involved in dehydro-D-arabinono-1,4-lactone biosynthetic process. Is expressed in organism." FBgn0037973 Alliance "Predicted to enable D-arabinose 1-dehydrogenase [NAD(P)+] activity. Predicted to be involved in dehydro-D-arabinono-1,4-lactone biosynthetic process. Is expressed in adult head." FBgn0013275 FlyBase Gene Snapshot Heat-shock-protein-70Aa (Hsp70Aa) encodes a protein involved in response to heat shock and hypoxia. FBgn0037963 UniProtKB Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (UniProtKB:Q9VGG5) FBgn0037962 UniProtKB May play a dynamic role in flagellar motility. (UniProtKB:Q9VGG6) FBgn0037960 FlyBase Gene Snapshot methuselah-like 5 (mthl5) encodes a G protein-coupled receptor involved in heart morphogenesis. FBgn0037958 Alliance Predicted to enable sphingomyelin phosphodiesterase D activity. Predicted to be involved in ceramide biosynthetic process; glycerophospholipid catabolic process; and sphingomyelin catabolic process. Is expressed in adult head and organism. Orthologous to human SMPD4 (sphingomyelin phosphodiesterase 4). FBgn0037956 Alliance Predicted to be active in membrane. Is expressed in adult head. Orthologous to several human genes including TPBG (trophoblast glycoprotein). FBgn0037955 Alliance "Predicted to enable cysteine-S-conjugate beta-lyase activity and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including KYAT3 (kynurenine aminotransferase 3)." FBgn0051116 FlyBase Gene Snapshot Chloride channel-a (ClC-a) encodes a plasma membrane chloride channel expressed in the stellate cells of Malpighian tubules. It is involved in transepithelial transport of ions and water. FBgn0025802 Alliance "Enables several functions, including chromatin binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of autophagosome maturation; positive regulation of transcription elongation by RNA polymerase II; and regulation of Rab protein signal transduction. Located in several cellular components, including cell cortex; polytene chromosome; and recycling endosome. Part of histone acetyltransferase complex; histone methyltransferase complex; and transcription elongation factor complex. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B2 and Charcot-Marie-Tooth disease type 4B3. Orthologous to human SBF1 (SET binding factor 1) and SBF2 (SET binding factor 2)." FBgn0037949 Alliance Enables small GTPase binding activity. Predicted to be involved in Golgi organization; lysosome localization; and regulation of protein localization. Located in Golgi apparatus. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). FBgn0017581 FlyBase Gene Snapshot "Lk6 kinase (Lk6) encodes the single ortholog of MAPK signal integrating kinases, which are phosphorylated and activated by ERK. Lk6 product phosphorylates the protein encoded by eIF4E1 to influence translation initiation via formation of the eIF4F complex." FBgn0037979 Alliance "Enables small GTPase binding activity. Predicted to be involved in protein localization to Golgi apparatus and retrograde transport, endosome to Golgi. Located in Golgi trans cisterna. Is expressed in adult head and spermatozoon. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2)." FBgn0037981 FlyBase Gene Snapshot Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex. FBgn0051361 Alliance "Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in several structures, including amnioserosa; embryonic/larval oenocyte; gland; larval ventral nerve cord; and visceral mesoderm derivative." FBgn0011905 Alliance Predicted to enable AAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0037995 Alliance Predicted to enable adenosine kinase activity. Predicted to be involved in AMP biosynthetic process and purine nucleobase metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). FBgn0037994 UniProtKB "mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. (UniProtKB:Q9VGC7)" FBgn0037993 Alliance Involved in synapse organization. Predicted to be active in neuron projection membrane. Is expressed in adult brain; embryonic/larval central nervous system; and ventral nerve cord. FBgn0037992 Alliance "Is expressed in several structures, including dorsal ectoderm; dorsal ectoderm anlage; embryonic Malpighian tubule tip cell; epithelium; and gut section." FBgn0037989 FlyBase Gene Snapshot ATPase 8B (ATP8B) encodes a phospholipid flippase involved in olfaction. FBgn0037988 Alliance Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in carbohydrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). FBgn0037987 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. FBgn0051358 Alliance Predicted to be active in plasma membrane. FBgn0037980 UniProtKB "Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:30670470, PubMed:31857346). Required for synaptic function and plasticity at larval neuromuscular junctions (NMJs) by promoting neurotransmitter release (PubMed:30670470). The DCX(DCAF12) complex catalyzes ubiquitination and degradation of yorkie (yki), thereby regulating the Hippo/SWH (Sav/Wts/Hpo) signaling pathway (PubMed:31857346). Acts as a regulator of tissue growth during development: required for the apoptotic elimination of supernumerary cells during metamorphosis (PubMed:26972874). (UniProtKB:Q9VGE3)" FBgn0037978 Alliance "Involved in imaginal disc fusion, thorax closure and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in organism. Orthologous to human KLHL18 (kelch like family member 18)." FBgn0051356 Alliance Predicted to enable ACA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038000 Alliance Involved in axoneme assembly. Located in cytosol; sperm flagellum; and sperm individualization complex. Is expressed in organism; spermatogonium; and spermatozoon. FBgn0038003 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0038008 Alliance Predicted to enable glycerophosphocholine phosphodiesterase activity. Predicted to be involved in glycerophospholipid catabolic process. Is expressed in spermatozoon. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1). FBgn0003651 UniProtKB "Receptor that is required in photoreceptors R1, R3, R4 and R6 during eye development; generation of the ganglion mother cell-2 (GMC-2) fate in the nb7-3 lineage, coinciding with the transition in the expression of HB to KR in the neuroblasts (NBs). (UniProtKB:P16376)" FBgn0038011 Alliance Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. FBgn0038017 Alliance "Predicted to enable carbohydrate binding activity. Is expressed in several structures, including adult head; adult heart; embryonic dorsal apodeme; embryonic esophagus; and epithelium." FBgn0010038 UniProtKB Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028). (UniProtKB:Q9VG98) FBgn0010039 UniProtKB Has no glutathione S-transferase activity. (UniProtKB:Q9VG97) FBgn0010040 UniProtKB Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028). (UniProtKB:Q9VG96) FBgn0010041 UniProtKB Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028). (UniProtKB:Q9VG95) FBgn0010042 UniProtKB Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028). (UniProtKB:Q9VG94) FBgn0010043 UniProtKB Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028). (UniProtKB:Q9VG93) FBgn0010044 FlyBase Gene Snapshot Glutathione S transferase D8 (GstD8) encodes an enzyme with broad substrate specificity involved in glutathione metabolism. FBgn0038029 Alliance Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. FBgn0053098 Alliance Predicted to enable myosin heavy chain binding activity. Predicted to be involved in locomotion and post-embryonic development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm. FBgn0038038 Alliance Predicted to be involved in glycolipid biosynthetic process. Predicted to be active in lipid droplet. Is expressed in adult head and adult heart. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). FBgn0038039 Alliance "Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; dorsal sensory complex primordium; embryonic head sensory system; embryonic/larval central nervous system; and sensory nervous system primordium. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6)." FBgn0082831 FlyBase Gene Snapshot protein partner of snf (pps) encodes a protein that is part of the machinery required for sex-specific splicing of the Sxl and tra pre-mRNAs. FBgn0038043 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human MYCBP (MYC binding protein). FBgn0038045 FlyBase Gene Snapshot "N-acetylneuraminic acid synthase (NANS) encodes an enzyme that catalyzes the condensation of N-acetylmannosamine 6-phosphate (ManNAc-6P) with phosphoenolpyruvate to produce N-acetylneuraminate 9-phosphate (NeuNAc-9P). It is involved in the biosynthesis of CMP-N-acetylneuraminate, a sugar donor required for the sialylation of glycoconjugates. It is also able to catalyze the condensation of N-acetylmannosamine (ManNAc) with phosphoenolpyruvate to produce 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)." FBgn0038047 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including ZNF254 (zinc finger protein 254); ZNF571 (zinc finger protein 571); and ZNF595 (zinc finger protein 595)." FBgn0038049 Alliance Involved in cellular response to hypoxia. Is expressed in adult head; adult heart; and organism. FBgn0043043 Alliance Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD5 (stearoyl-CoA desaturase 5). FBgn0029512 FlyBase Gene Snapshot Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. FBgn0038046 UniProtKB May regulate transcription of undefined genes. (UniProtKB:Q9VG73) FBgn0004103 UniProtKB Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase. (UniProtKB:P12982) FBgn0038042 FlyBase Gene Snapshot "Sarcoglycan beta (Scgbeta) encodes a component of the sarcoglycan complex, which is a sub-complex of the dystrophin glycoprotein complex. The product of Scgbeta negatively regulates the EGFR signaling pathway in eye imaginal discs." FBgn0000455 Alliance "Enables proline dipeptidase activity. Involved in proteolysis. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval garland cell; embryonic/larval midgut; and head mesoderm. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D)." FBgn0038037 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VG82) FBgn0038034 Alliance Predicted to enable iron ion binding activity. Is expressed in amnioserosa; embryonic/larval midgut; embryonic/larval plasmatocyte; and yolk nucleus. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; essential hypertension; familial Mediterranean fever; and leukemia (multiple). Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). FBgn0038020 Alliance Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. FBgn0042206 Alliance Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. FBgn0038018 FlyBase Gene Snapshot "Tim17a1 (Tim17a1) encodes a subunit of the TIM23 complex, which is a presequence translocase responsible for transporting proteins across the inner mitochondrial membrane. It modulates the gating of the transmembrane channel of TIM23 and plays a role in both matrix translocation as well as lateral membrane sorting." FBgn0038016 FlyBase Gene Snapshot MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. FBgn0038014 Alliance Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0038013 Alliance Enables serine hydrolase activity. Predicted to be involved in regulatory ncRNA-mediated heterochromatin formation. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including ARB2A (ARB2 cotranscriptional regulator A). FBgn0051432 Alliance Predicted to enable ACA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038007 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VGB3) FBgn0038006 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VGB4) FBgn0038005 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VGB5) FBgn0011270 Alliance "Predicted to enable 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity and bisphosphoglycerate mutase activity. Predicted to be involved in canonical glycolysis and gluconeogenesis. Predicted to be active in cytosol. Is expressed in adult head; elongation stage spermatid; primary spermatocyte; and spermatozoon. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM1 (phosphoglycerate mutase 1); PGAM2 (phosphoglycerate mutase 2); and PGAM4 (phosphoglycerate mutase family member 4)." FBgn0038001 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0037999 Alliance Predicted to enable butyryl-CoA dehydrogenase activity. Predicted to be involved in butyrate catabolic process and fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be active in mitochondrion. Is expressed in embryonic/larval oenocyte and organism. Human ortholog(s) of this gene implicated in alcohol use disorder and short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain). FBgn0037998 UniProtKB Required for normal Golgi function. (UniProtKB:Q9VGC3) FBgn0037996 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. FBgn0038053 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and mesoderm. Orthologous to human MFSD11 (major facilitator superfamily domain containing 11)." FBgn0038055 Alliance Predicted to be involved in apoptotic process. Predicted to be located in cytoplasm. Orthologous to human PDCD2L (programmed cell death 2 like). FBgn0038057 Alliance Predicted to enable single-stranded DNA binding activity. Predicted to be involved in DNA-templated transcription. Predicted to be part of RNA polymerase III complex. Is expressed in organism. Orthologous to human POLR3C (RNA polymerase III subunit C). FBgn0051354 FlyBase Gene Snapshot Hsp70Bbb (Hsp70Bbb) encodes a protein involved in response to heat shock and hypoxia. FBgn0013278 FlyBase Gene Snapshot Heat-shock-protein-70Bb (Hsp70Bb) encodes a protein involved in response to hypoxia heat shock and . FBgn0013279 FlyBase Gene Snapshot "Heat-shock-protein-70Bc (Hsp70Bc) encodes a protein involved in response to heat shock, hypoxia and drugs." FBgn0028374 UniProtKB Probably has a role in larval molting. (UniProtKB:Q9VG55) FBgn0038065 FlyBase Gene Snapshot Sorting nexin 3 (Snx3) encodes a protein involved in the secretion of the morphogen encoded by wg. It regulates the retromer-dependent recycling of the transmembrane cargo encoded by wls. FBgn0260444 UniProtKB "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). (UniProtKB:Q9V3G6)" FBgn0042207 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0038067 Alliance Predicted to enable triglyceride lipase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in egg; female reproductive system; oviduct; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0038068 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0038069 Alliance "Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0038071 Alliance Involved in gastrulation. Located in cell surface and vesicle. Is expressed in amnioserosa anlage; dorsal ectoderm; and presumptive wing vein. FBgn0038072 Alliance "Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic/larval glial cell; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2)." FBgn0038073 Alliance Is expressed in embryonic dorsal epidermis and embryonic ventral epidermis. FBgn0038074 FlyBase Gene Snapshot Glycine N-methyltransferase (Gnmt) encodes an enzyme that catalyzes the methylation reaction of glycine to generate sarcosine (N-methylglycine). It is abundantly expressed in the fat body and controls the amount of methyl donor S-adenosylmethionine. FBgn0011745 FlyBase Gene Snapshot "Actin-related protein 1 (Arp1) encodes the short filamentous component of the Dynactin complex, which plays an essential role in the activation of the Dynein microtubule motor protein. As such, the Arp1 product is required for diverse cellular processes such as intracellular transport, mitotic spindle assembly, chromosome movements, and nuclear positioning." FBgn0038079 Alliance Predicted to be involved in cell adhesion. Predicted to be located in membrane. Is expressed in wing disc. Orthologous to several human genes including NINJ2 (ninjurin 2). FBgn0016693 FlyBase Gene Snapshot "Putative Achaete Scute Target 1 (Past1) encodes a protein that associates predominantly with the plasma membrane and genetically interacts with N. It contributes to endocytosis, male sterility, temperature sensitivity, life span and differentiation of photoreceptors R1/R6/R7 and cone cells." FBgn0038080 Alliance Predicted to enable thiosulfate sulfurtransferase activity. Is expressed in adult head. Orthologous to human TSTD1 (thiosulfate sulfurtransferase like domain containing 1). FBgn0038082 Alliance Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Orthologous to human UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). FBgn0038084 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Is expressed in adult gnathal ganglion; adult mushroom body; antennal mechanosensory and motor center; synaptic neuropil domain; and testis. FBgn0038083 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0002719 FlyBase Gene Snapshot "Malic enzyme (Men) encodes a dehydrogenase that catalyzes the oxidation of malate to pyruvate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with the products of Idh, G6pd, and Pgd, in a small network of NADP reducing enzymes." FBgn0002905 FlyBase Gene Snapshot "DNA polymerase theta (PolQ) encodes DNA polymerase theta, a dual-domain protein with helicase-like and translesion polymerase domains. It contributes to repair/tolerance of DNA interstrand crosslinks and alternative-end joining repair of DNA double-strand breaks." FBgn0005355 FlyBase Gene Snapshot Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity. FBgn0001296 FlyBase Gene Snapshot karmoisin (kar) encodes a protein involved in ommochrome biosynthesis. FBgn0038076 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VG40) FBgn0026207 FlyBase Gene Snapshot members only (mbo) encodes a nucleoporin involved in immune response transduction by mediating the nuclear translocation of the product of Mad. FBgn0038070 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0005671 UniProtKB "Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity). (UniProtKB:P31409)" FBgn0013277 FlyBase Gene Snapshot Heat-shock-protein-70Ba (Hsp70Ba) encodes a protein involved in response to heat shock and hypoxia. FBgn0038058 Alliance Predicted to be involved in phosphatidylinositol biosynthetic process. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). FBgn0038056 Alliance "Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval somatic muscle cell; and sensory nervous system primordium. Used to study Parkinson's disease. Orthologous to human FBXO9 (F-box protein 9)." FBgn0038051 Alliance Predicted to be involved in Golgi organization. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. FBgn0038089 Alliance Predicted to enable calcium ion binding activity. Is expressed in elongation stage spermatid and primary spermatocyte. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). FBgn0038092 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. FBgn0038090 Alliance Predicted to enable RNA binding activity; histone H2AQ104 methyltransferase activity; and rRNA methyltransferase activity. Predicted to be involved in box C/D sno(s)RNA 3'-end processing and rRNA methylation. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Predicted to be active in Cajal body and nucleolus. FBgn0038088 Alliance "Predicted to enable calcium ion binding activity. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval posterior spiracle. Orthologous to several human genes including CAPSL (calcyphosine like)." FBgn0051345 Alliance Predicted to enable calcium ion binding activity. Orthologous to several human genes including CAPSL (calcyphosine like). FBgn0038095 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VG17) FBgn0038099 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in plasma membrane. Is expressed in organism. FBgn0038100 Alliance Predicted to enable translation repressor activity. Involved in negative regulation of translation and regulation of cell growth. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including PAIP2 (poly(A) binding protein interacting protein 2). FBgn0051342 Alliance Predicted to be active in cytoplasm and plasma membrane. Orthologous to human SDCBP (syndecan binding protein) and SDCBP2 (syndecan binding protein 2). FBgn0038106 Alliance Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in ribosomal small subunit assembly. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in Perrault syndrome 6. Orthologous to human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). FBgn0038108 Alliance Is expressed in organism. Orthologous to human FAM193A (family with sequence similarity 193 member A). FBgn0002354 FlyBase Gene Snapshot "lethal (3) 87Df (l(3)87Df) encodes an essential locus required in embryos, early larvae, late pupae and oogenesis." FBgn0003308 UniProtKB Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). (UniProtKB:P10351) FBgn0038113 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0038114 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic central brain surface glial cell and lateral cord surface glial cell. FBgn0001217 FlyBase Gene Snapshot Heat shock protein cognate 2 (Hsc70-2) encodes a member of the heat shock protein 70 family. It functions as chaperone protein in facilitating the proper folding of proteins. FBgn0051157 Alliance Is expressed in adult fat body and adult head. FBgn0004666 UniProtKB "Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord (PubMed:12221007, PubMed:1760843, PubMed:9840810). Required to correctly specify the formation of the central brain complex, which controls walking behavior (PubMed:12221007, PubMed:1760843, PubMed:9840810). Also required for correct patterning of the embryonic genital disk and anal pad anlage (PubMed:12221007, PubMed:1760843, PubMed:9840810). Plays a role in synapse development (PubMed:23644463). (UniProtKB:P05709)" FBgn0038118 FlyBase Gene Snapshot timeout (timeout) encodes a role in the maintenance of chromosome integrity and in the light synchronization of the adult circadian clock FBgn0038115 Alliance Predicted to enable methanethiol oxidase activity. Is expressed in adult head. Orthologous to human SELENBP1 (selenium binding protein 1). FBgn0003450 FlyBase Gene Snapshot snake (snk) encodes a secreted serine protease. It is a member of the protease cascade that generates the ligand that activates the receptor encoded by Tl. It contributes to establishment of the dorsal-ventral embryonic axis. FBgn0038110 Alliance "Predicted to be involved in regulation of microtubule-based process. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including adult head; adult heart; cuboidal/columnar epithelium; and embryonic/larval midgut. Orthologous to human MEMO1 (mediator of cell motility 1)." FBgn0038107 Alliance Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be active in cytosol and mitochondrion. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). FBgn0038105 UniProtKB "Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. (UniProtKB:Q9VG08)" FBgn0041710 UniProtKB "Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages. (UniProtKB:Q9VG09)" FBgn0038098 Alliance Is expressed in dorsal sensory complex proper primordium; embryonic antennal sense organ; embryonic labial sensory complex; embryonic maxillary sensory complex; and organism. FBgn0040493 FlyBase Gene Snapshot "granny smith (grsm) encodes a member of the M17 family of leucine aminopeptidases, a family of proteases broadly involved in a number of cellular processes. High throughput transcriptomic and proteomic analyses have implicated the product of grsm in the regulation of immune-, nervous- and immune-related processes." FBgn0038122 Alliance Orthologous to human CFAP299 (cilia and flagella associated protein 299). FBgn0038125 Alliance Predicted to enable ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding activity; and zinc ion binding activity. Predicted to be involved in ERAD pathway and ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. FBgn0040551 Alliance Is expressed in embryonic salivary gland duct; epithelial tube; and gut section. FBgn0003598 FlyBase Gene Snapshot Suppressor of variegation 3-7 (Su(var)3-7) encodes a protein associated with heterochromatin. Increasing the amount of the product of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing. FBgn0038130 Alliance Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; embryonic proventriculus; embryonic salivary gland duct; and embryonic/larval salivary gland common duct. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD5 (stearoyl-CoA desaturase 5). FBgn0038133 Alliance Predicted to be located in plasma membrane. Is expressed in spermatozoon. FBgn0038135 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Involved in dsRNA transport. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to human ENPEP (glutamyl aminopeptidase). FBgn0038136 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to human ENPEP (glutamyl aminopeptidase). FBgn0052473 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic anal pad; epithelium; germline cell; and gut section. Orthologous to human ENPEP (glutamyl aminopeptidase)." FBgn0038140 FlyBase Gene Snapshot "Pyrokinin 2 receptor 1 (PK2-R1) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system)." FBgn0045442 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0027610 FlyBase Gene Snapshot "Dicarboxylate carrier 1 (Dic1) encodes a protein of the inner mitochondrial membrane that catalyzes an electroneutral exchange across the inner mitochondrial membrane of dicarboxylates (e.g. malonate, malate, succinate) for inorganic phosphate and certain sulfur-containing compounds (e.g. sulfite, sulfate, thiosulfate). The main role of the product of is in gluconeogenesis. The carrier protein has also an anaplerotic role supplying substrates for the Krebs cycle." FBgn0038142 Alliance Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0038144 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0038145 Alliance Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1) and DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). FBgn0041711 Alliance Predicted to be active in extracellular region. Is expressed in organism. FBgn0038151 Alliance Predicted to be active in extracellular region. FBgn0038150 Alliance "Predicted to be active in extracellular region. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; gut section; and head epidermis primordium." FBgn0038149 UniProtKB Involved in the immune response to bacterial infection. (UniProtKB:Q95RA9) FBgn0038147 UniProtKB "Ligand for the CCHamide-2 receptor CCHa2-R (PubMed:21110953, PubMed:23293632). In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth (PubMed:26168160). In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides (PubMed:26020940). (UniProtKB:Q8SXL2)" FBgn0038146 Alliance "Predicted to be involved in rRNA processing. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; epithelial tube; gut section; and mesoderm. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36)." FBgn0044511 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult heart. Orthologous to human MRPS21 (mitochondrial ribosomal protein S21). FBgn0038143 Alliance Is expressed in adult head. FBgn0023495 Alliance "Enables phospholipase activity and triglyceride lipase activity. Involved in lipid catabolic process. Is expressed in embryonic/larval fat body; follicle cell; oocyte; organism; and ovary. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0038134 UniProtKB Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. (UniProtKB:Q9VFX1) FBgn0038132 UniProtKB Transmembrane protein that plays a key role in trachea development by regulating crb localization and maintenance at the apical cell membrane (PubMed:30645584). Required for anisotropic apical surface expansion important for tracheal tube elongation and lumen stability at larval stages (PubMed:30645584). (UniProtKB:Q9VFX3) FBgn0038129 Alliance Enables small GTPase binding activity. Located in Golgi apparatus. Is expressed in adult fat body and organism. Orthologous to human TBC1D5 (TBC1 domain family member 5). FBgn0038128 Alliance Predicted to enable DNA binding activity. Part of chromatin. Is expressed in organism. FBgn0000024 FlyBase Gene Snapshot "Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions." FBgn0038127 Alliance Predicted to enable misfolded protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum. Is expressed in spermatozoon. FBgn0038126 FlyBase Gene Snapshot CG8483 encodes a predicted secreted protein with a SCP/V5/TPX domain found in venom proteins. CG8483 overexpression causes variable levels of lethality suggesting excess protein may have toxic effects. FBgn0038153 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. FBgn0000046 UniProtKB "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (UniProtKB:P10981)" FBgn0051337 Alliance Is expressed in embryonic/larval lymph gland and embryonic/larval plasmatocyte. FBgn0004049 FlyBase Gene Snapshot "yurt (yrt) encodes a membrane-associated protein. It contributes to apical-basal polarity and permeability of septate junctions. In differentiating epithelial cells, it counteracts apical polarity proteins to sustain lateral membrane stability and apical-basal polarity. In fully differentiated cells, the product of yrt acts as a negative regulatory component of the crb complex and limits apical membrane growth." FBgn0038163 Alliance Predicted to enable calcium ion binding activity. Is expressed in adult head and spermatozoon. FBgn0015778 FlyBase Gene Snapshot rasputin (rin) encodes an RNA-binding protein that regulates gene expression. It is involved in eye development and the dorsal/ventral axis specification of the ovary. FBgn0038167 FlyBase Gene Snapshot "Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth." FBgn0024555 FlyBase Gene Snapshot falafel (flfl) encodes the regulatory 3 subunit of protein phosphatase 4 (PP4). It targets PP4 to the centromere to regulate kinetochore integrity in mitosis. It is also a key mediator for the localization of the product of mira and associated cell fate determinants during cell cycle. FBgn0038170 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme and ciliary base. Orthologous to human CFAP36 (cilia and flagella associated protein 36). FBgn0002937 UniProtKB "Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception. (UniProtKB:Q9VFS2)" FBgn0038173 Alliance Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). FBgn0038179 Alliance Located in nucleus. FBgn0038180 FlyBase Gene Snapshot Chitinase 5 (Cht5) encodes an enzyme involved in the formation of chitin-based extracellular matrix at barrier tissues. FBgn0038181 Alliance Predicted to be active in collagen-containing extracellular matrix. Is expressed in adult head; adult heart; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. Orthologous to human SRL (sarcalumenin). FBgn0260464 UniProtKB May regulate actin polymerization. (UniProtKB:Q9VFR1) FBgn0038183 Alliance Predicted to enable protein kinase regulator activity. Predicted to be active in nucleus. Orthologous to human BCCIP (BRCA2 and CDKN1A interacting protein). FBgn0000454 FlyBase Gene Snapshot Dipeptidase B (Dip-B) encodes a peptidase involved in protein metabolism. FBgn0051588 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051331 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038172 FlyBase Gene Snapshot Adenosine deaminase-related growth factor D (Adgf-D) encodes an adenosine deaminase involved in cell proliferation. FBgn0028487 Alliance "Predicted to be involved in signal transduction. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and male germline cell. Orthologous to human LRRC40 (leucine rich repeat containing 40)." FBgn0038168 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9VFS6)" FBgn0038166 UniProtKB "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). (UniProtKB:Q9VFS8)" FBgn0038165 FlyBase Gene Snapshot TWIK-related acid-sensitive K[+] channel 6 (Task6) encodes an ion channel involved in the transmembrane transport of potassium. FBgn0004237 FlyBase Gene Snapshot "Heterogeneous nuclear ribonucleoprotein at 87F (Hrb87F) encodes a hnRNP-A family RNA-binding protein, involved in gene expression and RNA processing. It is an essential component of the nucleoplasmic omega speckles and necessary for telomere maintenance. Hrb87F null mutants show defects in development, female fertility and stress tolerance." FBgn0010258 FlyBase Gene Snapshot RNA-binding protein 4 (Rbp4) encodes a protein that mediates the translational repression of CycB during meiosis in males. FBgn0000576 FlyBase Gene Snapshot "empty spiracles (ems) encodes a homeotic selector gene that encodes a transcription factor involved in spiracle morphogenesis, axogenesis, and development of the ventral nerve cord, brain and tracheal system." FBgn0047199 Alliance Is expressed in organism. FBgn0016672 FlyBase Gene Snapshot Inositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. FBgn0015270 FlyBase Gene Snapshot "Origin recognition complex subunit 2 (Orc2) encodes a subunit of the origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells. The product of Orc2 can be phosphorylated by CK2 and Cdks in vivo and in vitro." FBgn0038195 Alliance Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Located in endomembrane system. Is expressed in adult head and organism. Orthologous to several human genes including DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). FBgn0038196 Alliance Predicted to be involved in negative regulation of apoptotic process and protein stabilization. Orthologous to human HYPK (huntingtin interacting protein K). FBgn0038191 Alliance "Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Located in P granule. Is expressed in several structures, including egg chamber; fat body/gonad primordium; germarium; germline cell; and gonad." FBgn0038190 Alliance Is expressed in spermatozoon. Orthologous to human HDGFL3 (HDGF like 3). FBgn0038189 Alliance Predicted to enable histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in organism and ovary. FBgn0038188 Alliance Predicted to enable histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in organism and ovary. FBgn0008646 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to several human genes including EMX2 (empty spiracles homeobox 2)." FBgn0038186 Alliance Predicted to enable calcium ion binding activity. Predicted to be active in plasma membrane. Orthologous to human TESC (tescalcin). FBgn0051495 Alliance "Predicted to enable ATP hydrolysis activity. Predicted to be involved in Golgi to plasma membrane protein transport and intra-Golgi vesicle-mediated transport. Predicted to be active in Golgi stack. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase)." FBgn0002862 Alliance Predicted to enable structural molecule activity. Involved in spermatogenesis. Located in sperm flagellum. Is expressed in testis. FBgn0038197 UniProtKB "Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis. (UniProtKB:Q95V55)" FBgn0038198 Alliance "Predicted to enable sterol binding activity. Involved in sterol transport. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; dorsal epidermis primordium; embryonic hypopharynx; and epithelium. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2)." FBgn0038203 FlyBase Gene Snapshot Odorant receptor 88a (Or88a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0038206 FlyBase Gene Snapshot twinfilin (twf) encodes a ubiquitously expressed actin monomer binding protein that is structurally related to the product of tsr and inhibits actin filament assembly. It is highly conserved and is present in all eukaryotes except plants. Its roles include bristle and neuronal development. FBgn0027083 Alliance "Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Is expressed in adult head and organism. Used to study mitochondrial metabolism disease and neurodegenerative disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial)." FBgn0038213 Alliance Is expressed in spermatozoon. FBgn0027563 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0053329 Alliance Predicted to enable serine-type endopeptidase activity. Involved in response to bacterium and response to fungus. FBgn0051326 Alliance Predicted to be involved in proteolysis. FBgn0038211 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0011582 UniProtKB "Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis. (UniProtKB:P41596)" FBgn0051533 Alliance Is expressed in spermatozoon. FBgn0038209 Alliance Enables calcium channel activity and sodium channel activity. Involved in calcium ion transmembrane transport; positive regulation of intrinsic apoptotic signaling pathway; and sodium ion transmembrane transport. Located in Golgi apparatus. Is active in lysosomal membrane. Is expressed in adult head. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). FBgn0038208 Alliance Is expressed in organism and spermatozoon. FBgn0038207 Alliance "Is expressed in several structures, including embryonic epipharynx; embryonic foregut; embryonic salivary gland duct; embryonic/larval posterior spiracle; and epithelial tube." FBgn0010340 UniProtKB Essential for viability. (UniProtKB:P81928) FBgn0020510 FlyBase Gene Snapshot "Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis." FBgn0038205 Alliance Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human KIF19 (kinesin family member 19). FBgn0038202 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0038200 Alliance Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in mitochondrial matrix. Is expressed in adult head. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). FBgn0038199 UniProtKB "Neuropeptide ligand for the CCHamide-1 receptor CCHa1-R (PubMed:21110953, PubMed:23293632). Neuromessenger mediating signaling between neuronal cells of the circadian clock network involved in regulation of sleep latency (the time required to fall asleep), amount of sleep and depth of sleep (arousability) (PubMed:30246807, PubMed:36958331). Together with PDF, involved in regulating intensity and periodicity of daytime activity (PubMed:36786215). In subsets of clock neurons modulates the rhythmic expression of PDP1 and PDF, and together with PDF modulates the rhythmic expression of circadian protein PER/period, but not TIM/timeless (PubMed:30246807, PubMed:36786215). Mediates signaling from DN1a (anterior dorsal neurons 1) clock neurons to s-LNv (small ventral lateral neurons) clock neurons through CCHa1-R, contributing to regulation of activity rhythms by the circadian clock, particularly in the morning (PubMed:30246807). May be involved in signaling between clock neurons and non-clock neurons, such as the fan-shaped body, involved in sleep homeostasis (PubMed:36786215). In response to a high protein diet mediates hormonal signaling between the gut and a CCHa1-R expressing subset of dopaminergic cells in the protocerebral anterior medial (PAM) cluster of the brain (PubMed:36958331). This suppresses arousability by mechano-sensory stimulation (but not thermal stimulation) but is not involved in regulation of sleep patterns (PubMed:36958331). (UniProtKB:Q4V4I9)" FBgn0011971 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038221 Alliance Predicted to enable microtubule binding activity. Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in axoneme; centrosome; and ciliary basal body. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). FBgn0004855 UniProtKB DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). (UniProtKB:P36958) FBgn0051321 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; embryonic proventriculus inner layer; embryonic/larval posterior spiracle; and gut section. Orthologous to human SLC46A2 (solute carrier family 46 member 2). FBgn0013767 FlyBase Gene Snapshot "Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity." FBgn0011474 FlyBase Gene Snapshot SET domain containing 8 (Set8) encodes the histone methyltransferase that controls lysine20 monomethylation of the product of His4. This histone mark is essential for normal progression through the cell cycle. FBgn0038224 Alliance "Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis and proton transmembrane transport. Predicted to be part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human ATP5ME (ATP synthase membrane subunit e)." FBgn0003480 FlyBase Gene Snapshot spindle B (spn-B) encodes a member of the recA family. It is involved in double strand break repair in mitosis and meiosis. FBgn0038225 UniProtKB Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization. (UniProtKB:Q9VFK3) FBgn0024321 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including cephalic vascular remnant; embryonic/larval midgut primordium; gland; gut section; and mesoderm." FBgn0038223 FlyBase Gene Snapshot Aftiphilin (Afti) encodes an AP-1 adaptor complex binding protein involved in eye photoreceptor development and intracellular transport. FBgn0003567 UniProtKB "Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190. (UniProtKB:P08970)" FBgn0038234 Alliance Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Orthologous to human MRPL11 (mitochondrial ribosomal protein L11). FBgn0038236 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VFJ0) FBgn0038239 Alliance Enables chromatin binding activity. Located in mitochondrion and nucleolus. Part of transcription regulator complex. FBgn0020299 FlyBase Gene Snapshot "stumps (stumps) encodes a fibroblast growth factor (FGF) scaffolding protein. Upon FGF receptor activation, it mediates the recruitment of the phosphatase encoded by csw, which is essential for the activation of the MAPK pathway." FBgn0038246 Alliance Orthologous to human ERICH2 (glutamate rich 2). FBgn0013981 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0038247 FlyBase Gene Snapshot "Cadherin 88C (Cad88C) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication." FBgn0038250 Alliance Predicted to be involved in proteolysis. Located in extracellular region. Is expressed in embryonic/larval fat body. FBgn0038251 FlyBase Gene Snapshot "Hexamethylene bisacetamide inducible (Hexim) encodes an RNA binding protein. When associated with snRNA:7SKa, it recruits and inhibits the positive transcription elongation factor encoded by Cdk9. Regulated release and re-sequestration of the product of Cdk9 by the snRNA:7SKa snRNP plays an essential role in RNA polymerase II elongation control." FBgn0038252 FlyBase Gene Snapshot Histone H1 variant BigH1 (BigH1) encodes a germline linker histone H1 variant that is retained in the early embryo until cellularization. It is required for gametogenesis and to maintain silencing of the zygotic genome during early embryogenesis. FBgn0025808 Alliance Predicted to enable chromatin binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA damage checkpoint signaling; DNA repair; and mitotic DNA replication checkpoint signaling. Predicted to be part of Rad17 RFC-like complex. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). FBgn0038248 UniProtKB May play a role in cilium biogenesis. (UniProtKB:Q9VFH6) FBgn0003169 FlyBase Gene Snapshot punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put. FBgn0038244 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm." FBgn0004629 Alliance "Predicted to enable cysteine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including anterior endoderm anlage; dorsal ectoderm; dorsal epidermis primordium; gut section; and mesoderm." FBgn0038243 Alliance "Predicted to enable cysteine-type endopeptidase inhibitor activity. Is expressed in several structures, including adult heart; dorsal ectoderm anlage; dorsal epidermis primordium; dorsal imaginal tissue; and epithelium." FBgn0051313 Alliance Predicted to enable cysteine-type endopeptidase inhibitor activity. Is expressed in amnioserosa; embryonic dorsal epidermis; embryonic ventral epidermis; and yolk nucleus. FBgn0038237 UniProtKB "Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:15673286). Has cAMP phosphodiesterase activity in vitro but not in vivo (PubMed:15673286). Has a role regulating cGMP transport in Malpighian tubule principal cells (PubMed:16232123). (UniProtKB:Q9VFI9)" FBgn0038235 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; fat body primordium; and trunk mesoderm. Orthologous to human RRP36 (ribosomal RNA processing 36)." FBgn0038233 UniProtKB "Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1. (UniProtKB:Q9VFJ3)" FBgn0038260 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0038261 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in fat body/gonad primordium; gonad; and yolk nucleus. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0038262 Alliance Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0038266 Alliance Is expressed in adult heart and spermatozoon. FBgn0038268 UniProtKB Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans. (UniProtKB:Q95T10) FBgn0067628 UniProtKB "Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (UniProtKB:Q8INF2)" FBgn0067629 Alliance Is expressed in organism. Orthologous to human GPALPP1 (GPALPP motifs containing 1). FBgn0038271 Alliance "Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm. Used to study late onset Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple mitochondrial dysfunctions syndrome 6. Orthologous to several human genes including PMPCB (peptidase, mitochondrial processing subunit beta)." FBgn0038273 Alliance "Predicted to enable sequence-specific DNA binding activity. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; foregut primordium; and gut section." FBgn0038275 Alliance "Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Is expressed in adult head. Orthologous to human RRP15 (ribosomal RNA processing 15 homolog)." FBgn0038279 FlyBase Gene Snapshot Secreted decoy of InR (Sdr) encodes a secreted protein that shows extensive sequence similarity to the extracellular domain of the product of InR. It physically binds to insulin-like peptides and thereby modulates the insulin/IGF signaling pathway. FBgn0028662 FlyBase Gene Snapshot Vacuolar H[+] ATPase PPA1 subunit 1 (VhaPPA1-1) encodes a protein involved in tracheal terminal branching. FBgn0038277 Alliance Predicted to enable mRNA binding activity and rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly and translation. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in ribosome. Is expressed in adult head and organism. Orthologous to human RPS5 (ribosomal protein S5). FBgn0038274 Alliance "Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore organization; poly(A)+ mRNA export from nucleus; and protein import into nucleus. Predicted to be part of nuclear pore nuclear basket. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study nephrotic syndrome type 12. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93)." FBgn0038272 Alliance "Predicted to enable 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be located in cytoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 2. Orthologous to human DPH2 (diphthamide biosynthesis 2)." FBgn0004597 UniProtKB "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation. (UniProtKB:P25008)" FBgn0038269 FlyBase Gene Snapshot Rrp6 (Rrp6) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion and mRNA surveillance. FBgn0038258 Alliance Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). FBgn0038257 FlyBase Gene Snapshot "Senescence marker protein-30 (smp-30) encodes a calcium binding protein involved in calcium homeostasis regulation. It negatively influences cell proliferation and tissue size, possibly through the insulin pathway. It contributes to body size variation, diapause and thermal stress resistance." FBgn0011217 FlyBase Gene Snapshot "effete (eff) encodes a conserved class I E2 ubiquitin-conjugating enzyme that contributes to the protein ubiquitination and degradation pathway. The roles of the product of eff include female germline stem cell maintenance, eye development, apoptosis regulation and chromatin organization." FBgn0038256 Alliance Predicted to enable signaling receptor activity. Predicted to be located in membrane. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). FBgn0038280 Alliance Predicted to enable calcium ion binding activity. FBgn0038281 FlyBase Gene Snapshot "Ribosomal protein L10Aa (RpL10Aa) encodes a component of the large ribosomal subunit. It is likely a retrogene derived from RpL10Ab and, unlike RpL10Ab, the expression of RpL10Aa is low in most tissues/developmental stages but enriched in the adult testis." FBgn0038292 Alliance Involved in mesoderm development. Is expressed in embryonic proventriculus; embryonic/larval midgut; embryonic/larval visceral muscle cell; and gonad. FBgn0038296 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in sperm flagellum. Part of ubiquitin ligase complex. Is expressed in adult head; embryonic brain; larval ventral nerve cord; organism; and ventral midline of embryo. Orthologous to human RNF123 (ring finger protein 123). FBgn0038294 FlyBase Gene Snapshot "Myofilin (Mf) encodes a structural protein of muscular thick filaments, which may be needed for filament assembly. Alternative splicing of the gene, controlled by the product of salm, produces isoforms of varying size in thoracic muscles." FBgn0038286 UniProtKB "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. (UniProtKB:Q9VFD5)" FBgn0038285 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. FBgn0038300 FlyBase Gene Snapshot "Mau2 sister chromatid cohesion factor (Mau2) encodes a protein that interacts with the product of Nipped-B to form the kollerin complex, which loads the cohesin complex onto chromosomes. The product of Mau2 and cohesin participate in transcriptional regulation and DNA repair." FBgn0038302 Alliance Predicted to enable N-acetyltransferase activity. Orthologous to several human genes including SAT2 (spermidine/spermine N1-acetyltransferase family member 2). FBgn0038304 Alliance Predicted to enable GTPase activator activity. Predicted to be located in cytosol. Orthologous to human SGSM3 (small G protein signaling modulator 3). FBgn0038307 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human MRPS10 (mitochondrial ribosomal protein S10)." FBgn0014879 FlyBase Gene Snapshot "Set (Set) encodes a subunit of the inhibitor of histone acetyltransferase (INHAT) complex, which controls histone acetylation. It is involved in transcriptional regulation, which ultimately controls different processes such as p53-mediated apoptosis and neuronal development." FBgn0016691 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. (UniProtKB:Q24439)" FBgn0038312 Alliance Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Located in basolateral plasma membrane. Is expressed in adult head and organism. Orthologous to human SLC39A1 (solute carrier family 39 member 1). FBgn0038313 Alliance "Predicted to enable 18S rRNA aminocarboxypropyltransferase activity. Predicted to be involved in maturation of SSU-rRNA. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human TSR3 (TSR3 ribosome maturation factor)." FBgn0004117 UniProtKB "Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis. (UniProtKB:P09491)" FBgn0038315 Alliance "Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic head sensory system; embryonic/larval tracheal section; and gut section." FBgn0026441 FlyBase Gene Snapshot "ENL/AF9-related (ear) encodes a transcription factor that is a component of the super elongation complex (SEC), which regulates transcription by RNA Polymerase II. It also interacts with the histone methyltransferase encoded by gpp in the Dot1 complex (DotCom), which modifies chromatin structure by methylating histone H3 on lysine 79." FBgn0000533 FlyBase Gene Snapshot easter (ea) encodes a secreted serine protease that upon activation by the product of snk cleaves the ligand of the Toll pathway encoded by spz during early embryonic development. This ea role is restricted to the dorso-ventral patterning of the embryo. FBgn0038319 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Orthologous to human MRPL9 (mitochondrial ribosomal protein L9)." FBgn0038320 FlyBase Gene Snapshot Cytoplasmic FMR1 interacting protein (Cyfip) encodes an essential protein that is a component of the WAVE actin nucleator complex. It controls actin cytoskeleton remodeling and interacts with the products of Fmr1 and Rac1. It controls morphogenesis and synapse organization. FBgn0021750 FlyBase Gene Snapshot "Seryl-tRNA synthetase, mitochondrial (SerRS-m) encodes an enzyme that catalyses the aminoacylation of tRNAser with serine, to be used for gene translation during protein synthesis." FBgn0051301 Alliance Predicted to enable nucleic acid binding activity. Predicted to be active in nucleolus and nucleoplasm. Is expressed in organism. Orthologous to human NKRF (NFKB repressing factor). FBgn0038324 UniProtKB Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (UniProtKB:Q9VF81) FBgn0038326 Alliance "Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase)." FBgn0038327 FlyBase Gene Snapshot "Translin associated factor X (Trax) encodes a protein that, together with the product of trsn, forms the trsn/Trax complex, a ribonuclease that facilitates RNA-induced silencing complex (RISC) activation and has been implicated in many different processes, including starvation-induced sleep suppression." FBgn0038331 FlyBase Gene Snapshot "Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation." FBgn0041188 FlyBase Gene Snapshot "Ataxin-2 (Atx2) encodes the ortholog of human gene ATXN2, which is implicated in spinocerebellar ataxia 2. It contributes to eye development, circadian behaviour, and microRNA function." FBgn0038339 Alliance "Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including dorsal ridge; dorsal ridge primordium; embryonic anal pad; embryonic esophagus; and epithelium." FBgn0038337 Alliance Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; embryonic large intestine; and yolk nucleus. Orthologous to human SLC26A11 (solute carrier family 26 member 11). FBgn0038334 Alliance Is expressed in adult head; elongation stage spermatid; and primary spermatocyte. FBgn0038332 UniProtKB Involved in copper homeostasis. (UniProtKB:Q9VF71) FBgn0038330 Alliance "Is expressed in several structures, including embryonic central brain neurons; embryonic head sensory system; ganglia; sense organ; and sensory cluster. Orthologous to human CCDC149 (coiled-coil domain containing 149)." FBgn0026737 UniProtKB Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. (UniProtKB:A8JR14) FBgn0026634 UniProtKB Required for normal Golgi morphology and function. (UniProtKB:Q9VF78) FBgn0038325 FlyBase Gene Snapshot "Autophagy-related 4b (Atg4b) encodes a cysteine protease that cleaves the precursor product of Atg8a at the C-terminal region, thereby initiating autophagosome formation." FBgn0019925 UniProtKB Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. (UniProtKB:O18405) FBgn0038321 FlyBase Gene Snapshot "N-acetylglucosamine kinase (Nagk) encodes a putative enzyme that is predicted to catalyze the phosphorylation of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and thus may be involved in N-acetyl-D-glucosamine metabolism." FBgn0013269 FlyBase Gene Snapshot FK506-binding protein 39kD (Fkbp39) encodes a protein thay acts as an inhibitor of autophagy in larval fat body. FBgn0038318 Alliance Is expressed in adult head. FBgn0038316 Alliance Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism. FBgn0011476 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). FBgn0027378 FlyBase Gene Snapshot MORF-related gene 15 (MRG15) encodes a protein that contributes to histone acetylation. It is involved in chromatin organization and chromosome separation. FBgn0000283 FlyBase Gene Snapshot "Centrosomal protein 190kD (Cp190) encodes a BTB-ZnF transcription factor that has both nuclear and centrosomal functions. It's an insulator protein required to form physical and regulatory boundaries in the genome, and is recruited by DNA-binding proteins such as CTCF, su(Hw) and others, with which it physically associates." FBgn0038309 FlyBase Gene Snapshot Ammonium transporter (Amt) encodes a protein required for ammonia detection. FBgn0045035 UniProtKB Serine/threonine-protein kinase which recognizes the substrate consensus sequence (UniProtKB:Q5EAK6) FBgn0038306 Alliance "Predicted to enable histone methyltransferase activity and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in several structures, including anal pad primordium; anterior endoderm; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Orthologous to human PRMT3 (protein arginine methyltransferase 3)." FBgn0051344 Alliance "Predicted to enable oxidoreductase activity. Is expressed in several structures, including adult fat body; adult head; embryonic epipharynx; epithelium; and gut section." FBgn0051155 Alliance "Predicted to enable single-stranded DNA binding activity; single-stranded RNA binding activity; and translation initiation factor binding activity. Predicted to be involved in regulation of gene expression and transcription initiation at RNA polymerase II promoter. Part of RNA polymerase II, core complex. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human POLR2G (RNA polymerase II subunit G)." FBgn0038303 UniProtKB May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Has a role in one of the several mechanisms underlying dendritic localization of Shal channels. (UniProtKB:Q9VFB7) FBgn0038301 Alliance Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anlage in statu nascendi; embryonic brain; embryonic/larval nervous system; and organism. FBgn0038299 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Involved in epithelium regeneration and regulation of stem cell division. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); retinal vascular disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINC1 (serpin family C member 1); SERPINE2 (serpin family E member 2); and SERPINI2 (serpin family I member 2)." FBgn0028984 UniProtKB Serine protease inhibitor with activity toward trypsin (PubMed:18956323). Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin (PubMed:19581577). Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade (PubMed:19581577). Essential for unfolding and expansion of the wings after emergence from the pupal case (PubMed:18956323). May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz (PubMed:19581577). (UniProtKB:Q9VFC2) FBgn0000047 UniProtKB "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (UniProtKB:P83967)" FBgn0038342 UniProtKB "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273). Required for ciliary structure and function (PubMed:27577095). (UniProtKB:Q9VF59)" FBgn0019940 FlyBase Gene Snapshot Rhodopsin 6 (Rh6) encodes a visual GPCR opsin that covalently binds the chromophore retinal. A photon of light stimulates the isomerization of retinal resulting in a conformational change in the product of Rh6 and signal activation. Its peak sensitivity is in the green and it is expressed in a subclass of R8 photoreceptors. FBgn0038344 FlyBase Gene Snapshot obelus (obe) encodes a Ski2-family helicase that regulates alternative mRNA splicing of crb. It is required for cell polarity and adherens junction organization. FBgn0038345 Alliance Predicted to enable RNA binding activity. Involved in positive regulation of gene expression. Located in nucleus. Part of euchromatin. FBgn0038350 FlyBase Gene Snapshot Aldehyde oxidase 4 (AOX4) encodes an oxidoreductase that catalyzes the oxidation of pyridoxal to pyridoxate with the release of hydrogen peroxide. FBgn0038349 FlyBase Gene Snapshot Aldehyde oxidase 3 (AOX3) encodes a pyridoxal oxidase involved in pyridoxal metabolism. FBgn0038348 FlyBase Gene Snapshot Aldehyde oxidase 2 (AOX2) encodes a pyridoxal oxidase involved in pyridoxal metabolism. FBgn0051296 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. FBgn0038343 UniProtKB "Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. (UniProtKB:Q4V645)" FBgn0053207 FlyBase Gene Snapshot "pxb (pxb) encodes a protein involved in response to ethanol, long-term memory and regulation of hemocyte proliferation." FBgn0038354 Alliance Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult glial cell and adult head. Orthologous to human SLC26A11 (solute carrier family 26 member 11). FBgn0038355 Alliance Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Is expressed in adult head and organism. Orthologous to human TOMM40L (translocase of outer mitochondrial membrane 40 like). FBgn0038358 Alliance Predicted to enable intraciliary transport particle B binding activity. Predicted to be involved in intraciliary anterograde transport and intraciliary transport involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in ciliary basal body and ciliary base. Orthologous to human IFT56 (intraflagellar transport 56). FBgn0038359 Alliance Predicted to be involved in cilium assembly. Predicted to be active in centrosome; ciliary basal body; and motile cilium. Orthologous to human CEP20 (centrosomal protein 20). FBgn0038360 Alliance Enables small GTPase binding activity. Located in Golgi cis cisterna. Is expressed in embryonic proventriculus; embryonic/larval salivary gland; organism; and salivary gland body primordium. Orthologous to human FAM114A1 (family with sequence similarity 114 member A1) and FAM114A2 (family with sequence similarity 114 member A2). FBgn0038361 Alliance Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). FBgn0038363 FlyBase Gene Snapshot Acylphosphatase 2 (Acyp2) encodes a small cytosolic enzyme that catalyses the hydrolysis of carboxyl phosphate bonds. Its exact role and function are unknown. FBgn0038365 Alliance Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3) and ANGPTL4 (angiopoietin like 4). FBgn0026616 FlyBase Gene Snapshot alpha-Mannosidase class II b (alpha-Man-IIb) encodes a mannosidase involved in cellular encapsulation response and glycoprotein metabolism. FBgn0038366 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in several structures, including embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic ventral apodeme; gut section; and sensory nervous system primordium." FBgn0038369 Alliance Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in cytoskeleton. Predicted to be part of Arp2/3 protein complex. Is expressed in adult head. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). FBgn0003483 UniProtKB "Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis. (UniProtKB:Q9VF26)" FBgn0038373 Alliance "Predicted to enable creatine kinase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and spermatozoon. Orthologous to human CKMT1A (creatine kinase, mitochondrial 1A); CKMT1B (creatine kinase, mitochondrial 1B); and CKMT2 (creatine kinase, mitochondrial 2)." FBgn0051183 Alliance "Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; essential hypertension; and myocardial infarction. Orthologous to several human genes including NPR1 (natriuretic peptide receptor 1)." FBgn0038376 Alliance Predicted to enable ABC-type heme transporter activity and heme binding activity. Involved in cellular detoxification of cadmium ion. Located in vacuolar membrane. Is expressed in adult head; adult heart; embryonic/larval midgut; gastric caecum; and organism. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)). FBgn0038371 FlyBase Gene Snapshot "PSEA-binding protein 45kD (Pbp45) encodes a protein that functions as one of three subunits of the small nuclear RNA (snRNA) activating protein complex, which binds as a complex to a proximal sequence element A (PSEA) to activate transcription of snRNA genes." FBgn0017567 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (UniProtKB:Q9VF27) FBgn0003227 FlyBase Gene Snapshot recombination-defective (rec) interacts with other Mini-Chromosome Maintenance (MCM)-related proteins (encoded by mei-217 and mei-218) to make meiotic crossovers. FBgn0000246 FlyBase Gene Snapshot "crossover suppressor on 3 of Gowen (c(3)G) encodes the transerve filament protein of the synaptonemal complex. It is required for many meiotic processes, including homolog pairing, recombination, and chromosome segregation at meiosis I." FBgn0051294 Alliance Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in drug dependence; heroin dependence; nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). FBgn0038381 FlyBase Gene Snapshot "Endoribonuclease U-specific (EndoU) encodes a endoribonuclease belonging to the eukaryotic endoU ribonuclease family. It is essential for viability and plays a crucial role in the nervous system, contributing to complex neuronal networks largely dependent on cholinergic neurons." FBgn0038385 FlyBase Gene Snapshot F-box and leucine-rich repeat protein 7 (Fbxl7) encodes a ubiquitin ligase that regulates Hippo signaling. FBgn0038387 FlyBase Gene Snapshot "black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions (""black pearls"") in blp-deficient flies." FBgn0013334 FlyBase Gene Snapshot Synapse-associated protein 47kD (Sap47) encodes a conserved protein associated with synaptic vesicles. It is required for intact synaptic and behavioural plasticity. FBgn0038389 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Is expressed in organism. Orthologous to human ZCCHC10 (zinc finger CCHC-type containing 10). FBgn0038390 FlyBase Gene Snapshot "Retinoblastoma-family protein 2 (Rbf2) encodes a transcriptional repressor belonging to the retinoblastoma family. It is mainly known for its role in repressing cell-cycle genes, but can also attenuate expression of other housekeeping genes, as-well as cell type specific enhancers." FBgn0022787 FlyBase Gene Snapshot Helicase 89B (Hel89B) encodes a protein that belongs to the SNF2 family of chromatin regulators. Hel89B product binds to large number of sites on polytene chromosomes and positively regulates the expression of antimicrobial peptide genes. FBgn0038391 FlyBase Gene Snapshot GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. FBgn0003117 FlyBase Gene Snapshot "pannier (pnr) encodes a transcription factor that acts as an activator of proneural achaete-scute complex genes. Its roles include dorsal cell fate determination, nervous system development and lymph gland development." FBgn0038394 Alliance Predicted to be active in extracellular space. FBgn0038396 Alliance "Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine)." FBgn0027948 UniProtKB "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization (Probable) (PubMed:10477755, PubMed:11433295, PubMed:15530399, PubMed:15775959, PubMed:16303556, PubMed:26953351, PubMed:32066907). Function in neurons is essential for adult survival, and is important for climbing behavior and activity (PubMed:37041188). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:16303556, PubMed:17889670). May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage (PubMed:15775959). Involved in mitotic spindle elongation (PubMed:16303556). Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts (PubMed:26953351). Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd (PubMed:11433295). Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization (PubMed:15530399). Seems to be involved in elongation of kinetochore-derived microtubule fibers (PubMed:19836241). In fat body cells, essential component of perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) which function to accommodate the organization of microtubule (MT) networks to control nuclear positioning and dynein motor-based retrograde endosomal trafficking (PubMed:32066907). Within the ncMTOCs, Msp300 and shot anchors the ncMTOC at the nuclear surface and recruits the MT minus-end regulators Patronin and Nin for assembly, anchoring and/or stabilization of circumferential and radial MTs at the ncMTOCs (PubMed:32066907). Patronin, and perhaps Nin, then recruits msps to the ncMTOC where it is required for the gamma-tubulin-independent elongation and assembly of radial MTs (PubMed:32066907). (UniProtKB:Q9VEZ3)" FBgn0038398 Alliance "Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0010379 FlyBase Gene Snapshot "Akt kinase (Akt) encodes the core kinase component of the insulin/insulin-like growth factor pathway. It functions downstream of the product of Pi3K92E and is activated by phosphatidylinositol binding and phosphorylation. It regulates cell growth and survival, stress responses and ageing." FBgn0052855 Alliance "Is expressed in several structures, including embryonic epipharynx; epipharynx primordium; gut section; hindgut proper primordium; and proventriculus primordium." FBgn0038397 Alliance Orthologous to human NWD2 (NACHT and WD repeat domain containing 2). FBgn0024222 FlyBase Gene Snapshot I-kappaB kinase beta (IKKbeta) encodes a a component of the IkappaB Kinase (IKK) complex together with the product of key. IKK complex participates in the activation of the transcription factor encoded by Rel in the immune deficiency pathway. This pathway regulates the antibacterial response and other less characterized cellular processes. FBgn0038395 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and spermatozoon. FBgn0002783 FlyBase Gene Snapshot moira (mor) encodes a member of the trithorax group of homeotic gene regulators. The product of mor is a chromatin remodeling protein and functions as the Swi3 component of the Brahma complex. FBgn0052856 Alliance Predicted to be involved in transcription by RNA polymerase II and transcription initiation at RNA polymerase III promoter. Predicted to be located in nucleus. FBgn0038388 Alliance Is expressed in adult head and organism. FBgn0051088 Alliance "Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic dorsal epidermis; embryonic/larval midgut primordium; and ganglia." FBgn0027657 FlyBase Gene Snapshot globin 1 (glob1) encodes a peroxidase involved in the response to oxidative stress and the maintenance of F-actin based cytoskeleton. FBgn0038380 Alliance Predicted to enable natriuretic peptide receptor activity and peptide hormone binding activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). FBgn0003319 UniProtKB "Hormone dependent protease required for epithelial morphogenesis, including the formation of bristles, legs, and wings. Has a dual function, detaches imaginal disk cells from extracellular matrices through its extracellular proteolytic domain and transmits an outside-to-inside signal to its intracellular domain to modify the cytoskeleton during morphogenesis. (UniProtKB:Q05319)" FBgn0038401 Alliance Predicted to enable GTPase activator activity. Is expressed in adult head and organism. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). FBgn0063649 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Orthologous to human SLC22A7 (solute carrier family 22 member 7). FBgn0038404 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0040071 FlyBase Gene Snapshot "taranis (tara) encodes a transcriptional co-regulator that interacts with chromatin remodeling complexes, cell cycle proteins, and the JNK signaling pathway. It contributes to sleep, neural progenitor proliferation, and cell fate maintenance." FBgn0020407 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5 (PubMed:23097424). Plays a role as a regulator of spermatogenesis (PubMed:19357193). Crucial regulator of the mitotic cell cycle and development (PubMed:15737938, PubMed:19357193). Required for the correct dynein-dynactin perinuclear localization important for nucleus-centrosome coupling that occur upon meiotic progression of primary spermatocytes (PubMed:19357193, PubMed:23904267). Plays a role in sperm motility and fertility (PubMed:19357193). May have a role in the PNG/PLU/GNU pathway (PubMed:15737938). (UniProtKB:Q9VEX5)" FBgn0020399 Alliance Involved in spermatogenesis. Is expressed in testis. FBgn0038412 FlyBase Gene Snapshot Zinc/iron regulated transporter-related protein 89B (Zip89B) encodes a protein involved in zinc detoxification and zinc transmembrane import. FBgn0011858 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012011 Alliance Predicted to enable GUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038414 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in hexose transmembrane transport. Predicted to be located in membrane. FBgn0038415 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in hexose transmembrane transport. Predicted to be located in membrane. FBgn0038416 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in hexose transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. FBgn0040271 FlyBase Gene Snapshot "Sulfated (Sulf1) encodes a heparan sulfate modifying enzyme, which extracellularly removes specific 6-O-sulfate groups from heparan sulfate in a post-synthetic manner. It regulates Wg signaling by reducing extracellular wg protein levels. It also regulates Hh signaling by acting as a positive regulator in cells producing the product of hh and a negative regulator in cells receiving the product of hh." FBgn0038407 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including adult fat body; extraembryonic structure; ganglia; glial cell; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A16 (solute carrier family 22 member 16)." FBgn0024491 FlyBase Gene Snapshot "Bicoid interacting protein 1 (Bin1) interacts with sequence-specific transcription factors (e.g. the product of bcd, Kr, Trl) to help recruit the Sin3A-HDAC1 histone deacetylase co-repressor complex to target genes. The product of Bin1 contributes to axis patterning and embryonic segmentation via transcription regulation." FBgn0038402 FlyBase Gene Snapshot 48 related 2 (Fer2) encodes a bHLH-transcription factor required for the development of a subset of circadian pacemaker neurons and dopaminergic neurons in the protocerebral anterior medial (PAM) and the protocerebral anterior lateral clusters. It is also required for the survival of the PAM cluster dopaminergic neurons in adulthood. FBgn0038400 Alliance "Predicted to be involved in cristae formation. Part of MICOS complex. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Orthologous to several human genes including APOOL (apolipoprotein O like)." FBgn0038418 Interactive Fly zinc finger transcription factor - repressor of achaete and scute during bristle development FBgn0027095 FlyBase Gene Snapshot "Mesencephalic astrocyte-derived neurotrophic factor (Manf) encodes an evolutionarily conserved neurotrophic factor. It contributes to dopamine neuron survival, regulation of unfolded protein response and retinal repair." FBgn0051282 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038424 Alliance "Predicted to enable protein prenyltransferase activity. Predicted to contribute to protein farnesyltransferase activity. Predicted to be part of protein farnesyltransferase complex. Is expressed in organism. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to human CHURC1-FNTB (CHURC1-FNTB readthrough) and FNTB (farnesyltransferase, CAAX box, subunit beta)." FBgn0038425 Alliance Predicted to enable (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human ARMC7 (armadillo repeat containing 7). FBgn0038429 Alliance "Predicted to enable [methionine synthase] reductase (NADPH) activity. Predicted to be involved in methionine biosynthetic process. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase)." FBgn0038431 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0038432 Alliance "Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in N-acylethanolamine metabolic process; ethanolamine metabolic process; and phospholipid metabolic process. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic head epidermis; ganglia; and sensory nervous system primordium. Orthologous to human GDE1 (glycerophosphodiester phosphodiesterase 1)." FBgn0027053 FlyBase Gene Snapshot COP9 signalosome subunit 5 (CSN5) encodes the subunit 5 of the COP9 signalosome (CSN). The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. The product of CSN5 is an isopeptidase that deNEDDylates the cullin subunit of E3-cullin RING ubiquitin ligases. FBgn0038435 FlyBase Gene Snapshot "Guanylyl cyclase at 89Da (Gyc89Da) encodes an atypical soluble guanylyl cyclase. It heterodimerizes with the product of Gyc88E to form an oxygen-sensitive soluble guanylyl cyclase, which likely functions as a neuronal oxygen detector, activated at reduced oxygen levels." FBgn0038436 FlyBase Gene Snapshot "Guanylyl cyclase at 89Db (Gyc89Db) encodes an atypical soluble guanylyl cyclase. It heterodimerizes with the product of Gyc88E to form an oxygen-sensitive soluble guanylyl cyclase, which likely functions as a neuronal oxygen detector, activated at reduced oxygen levels." FBgn0038445 Alliance Predicted to enable nucleic acid binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in spermatozoon. FBgn0038446 Alliance Predicted to enable aminoacyl-tRNA hydrolase activity. Orthologous to human PTRHD1 (peptidyl-tRNA hydrolase domain containing 1). FBgn0028381 FlyBase Gene Snapshot Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1. FBgn0038439 UniProtKB Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (UniProtKB:Q9VEU1) FBgn0038438 Alliance Predicted to enable signal recognition particle binding activity. Involved in defense response to bacterium. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to several human genes including DERL2 (derlin 2). FBgn0038437 FlyBase Gene Snapshot Succinate dehydrogenase assembly factor 3 (Sdhaf3) encodes a protein chaperone that functions within the mitochondrial matrix and mediates the biogenesis of the product of SdhB. FBgn0044826 FlyBase Gene Snapshot "Pak3 (Pak3) encodes a Ser/Thr kinase implicated in myoblast fusion, synapse development, wound healing and border cell migration. It functions downstream of the small Rac GTPases to regulate actin cytoskeletal organization." FBgn0038428 Alliance Located in cytosol. Is expressed in embryonic/larval midgut and organism. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). FBgn0038426 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Used to study intrinsic cardiomyopathy. Orthologous to human MRPS33 (mitochondrial ribosomal protein S33). FBgn0051497 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0003513 FlyBase Gene Snapshot spineless (ss) encodes a protein that plays a key role in defining the distal regions of the antenna and the leg. Its stochastic expression in R7 photoreceptors also controls the expression of color Rhodopsins (the product of Rh4 vs. the product of Rh3) in the two subsets of ommatidia. FBgn0038422 Alliance Predicted to enable chitin binding activity. Located in extracellular region. Is expressed in spermatozoon. FBgn0038421 Alliance Located in cytosol. Is expressed in adult brain and adult brain cell body rind. Orthologous to several human genes including SERF2 (small EDRK-rich factor 2). FBgn0038420 Alliance Predicted to be located in membrane. Is expressed in adult head. FBgn0038419 Alliance Predicted to enable carbohydrate binding activity and galactoside binding activity. Is expressed in embryonic/larval midgut. FBgn0038447 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to human PRSS21 (serine protease 21). FBgn0027109 FlyBase Gene Snapshot "neuropeptide F (NPF) encodes a 36-residue amidated peptide that signals through its receptor NPFR activating an inhibitory G-protein. Major functions of NPF signaling include the regulation of feeding and courtship behavior, metabolism, alcohol sensitivity, aggression as well as learning and memory. It further plays a role in the regulation of circadian behavior, in particular by modifying evening activity and free-running period." FBgn0038449 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult fat body; adult head; and embryonic/larval oenocyte. FBgn0038450 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult fat body; adult head; and adult heart. FBgn0038451 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult head. FBgn0015520 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding); PSPC1 (paraspeckle component 1); and SFPQ (splicing factor proline and glutamine rich). FBgn0038453 Alliance "Involved in endoplasmic reticulum tubular network membrane organization and mitochondrion organization. Is active in endoplasmic reticulum tubular network. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; ganglia; and mesoderm. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 61. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1)." FBgn0015019 UniProtKB "Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (UniProtKB:P48605)" FBgn0015230 UniProtKB Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. (UniProtKB:P53403) FBgn0020556 Interactive Fly produces non-coding RNA that may mediate or counteract epigenetic silencing - bxd RNA mediates recruitment of Ash1 to stimulates gene expression FBgn0063261 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. Is expressed in organism. FBgn0003944 FlyBase Gene Snapshot "Ultrabithorax (Ubx) encodes a homeodomain transcription factor involved in cell fate decisions, cell proliferation and organ identity. Ubx mutants can show a second set of wings due to appendage transformation." FBgn0051217 FlyBase Gene Snapshot modular serine protease (modSP) encodes a protein that functions downstream of microbial sensing receptors encoded by PGRP-SA and GNBP3 in the extracellular proteolytic cascade leading to Toll pathway activation during the immune response. It initiates the proteolytic cascade leading to the cleavage of the Toll ligand encoded by spz. FBgn0038455 Alliance Is expressed in organism. FBgn0015351 Alliance "Enables U2 snRNA adenosine m6 methyltransferase activity. Involved in snRNA methylation. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine)." FBgn0038454 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Is expressed in organism. Orthologous to human GPKOW (G-patch domain and KOW motifs)." FBgn0038452 Alliance Is expressed in chordotonal neurons. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 20. Orthologous to several human genes including CCDC63 (coiled-coil domain containing 63). FBgn0022344 Alliance Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be active in mitochondrion. Is expressed in adult heart. Orthologous to human ATPAF1 (ATP synthase mitochondrial F1 complex assembly factor 1). FBgn0027562 Alliance Predicted to enable scavenger receptor activity. Involved in defense response to protozoan. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in embryonic/larval anterior spiracle; embryonic/larval garland cell; and testis. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). FBgn0020907 Alliance "Enables GTPase activity. Is expressed in several structures, including Malpighian tubule primordium; adult head; brain; embryonic Malpighian tubule tip cell; and larval ventral nerve cord." FBgn0038458 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase, V0 domain. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2)." FBgn0038463 Alliance Predicted to enable D-xylulokinase activity. Predicted to be involved in carbohydrate phosphorylation and xylulose metabolic process. Predicted to be located in extracellular exosome. Predicted to be active in cytosol. Orthologous to human XYLB (xylulokinase). FBgn0038465 FlyBase Gene Snapshot Immune-regulated catalase (Irc) encodes a catalase involved in oxidant detoxification. FBgn0038466 Alliance Predicted to be involved in olfactory behavior. Predicted to be located in synapse. Is expressed in adult head; embryonic proventriculus; embryonic/larval midgut; foregut primordium; and proventriculus primordium. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to several human genes including EPS8L1 (EPS8 signaling adaptor L1). FBgn0038467 FlyBase Gene Snapshot Adenylosuccinate lyase (Adsl) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology. FBgn0038462 Alliance Predicted to be part of EMC complex. Is expressed in adult head. Orthologous to human EMC2 (ER membrane protein complex subunit 2). FBgn0038461 Alliance Predicted to be part of EMC complex. Is expressed in adult heart. Orthologous to human EMC2 (ER membrane protein complex subunit 2). FBgn0015011 FlyBase Gene Snapshot "Adenosylhomocysteinase like 2 (AhcyL2) encodes a protein that, together with the product of AhcyL1, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and production of deoxyribonucleotides." FBgn0000015 FlyBase Gene Snapshot "Abdominal B (Abd-B) is one of the three hox genes of the bithorax complex. The product of Abd-B specifies the identity of the posterior abdominal segments, the external genitalia and the gonads. It is also involved in regulating the post-mating-response." FBgn0000014 FlyBase Gene Snapshot abdominal A (abd-A) encodes a homeobox-containing transcription factor component of the bithorax complex. It contributes to the developmental fate of embryonic segments. FBgn0038471 UniProtKB "Methylates the 2'-O-ribose of nucleotides at positions 32 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:31943105). Plays a role in neurogenesis (PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:31943105). May modify position 32 in tRNA(Arg(ACG)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gln(CUC)), tRNA(Leu(CAA)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), tRNA(Trp(CCA)), tRNA(Val(TAC)), tRNA(Val(CAC)), and tRNA(Val(AAC)) (PubMed:31943105). (UniProtKB:Q9VEP1)" FBgn0038476 FlyBase Gene Snapshot kugelkern (kuk) encodes a nuclear envelope protein required for nuclear elongation during cellularization. It shares structural and functional similarities to lamins. FBgn0038478 FlyBase Gene Snapshot chromosome alignment defect 1 (cal1) encodes a protein that is required for maintenance of the epigenetic marks specifying centromeres. It binds to newly synthesized centromere-specific histone H3 variant encoded by cid and recruits it to the centromere by binding to the centromere protein encoded by Cenp-C. FBgn0051269 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0051265 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0051267 Alliance Predicted to be involved in proteolysis. FBgn0038484 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0038485 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0038486 Alliance "Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked and fatty acid metabolic process. Predicted to be active in peroxisome. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase)." FBgn0038490 Alliance Predicted to enable oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity and uracil DNA N-glycosylase activity. Predicted to be involved in base-excision repair. Orthologous to human SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1). FBgn0038491 Alliance "Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval salivary gland; germline cell; and pole plasm. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2)." FBgn0038494 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Is expressed in adult head. FBgn0051262 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0038492 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval proventriculus; embryonic/larval salivary gland; and organism. FBgn0038488 Alliance Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Is expressed in elongation stage spermatid; organism; and primary spermatocyte. FBgn0038487 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0038482 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0038481 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0038479 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0038475 FlyBase Gene Snapshot Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. FBgn0038473 FlyBase Gene Snapshot Nucleostemin 1 (Ns1) encodes a GTPase that is enriched in the peripheral granular components of nucleoli of most larval and adult cells. It is required for nucleolar release of the large ribosomal subunit. Depletion of the Ns1 product reduces viability of midgut imaginal island cells and ribosome abundance in polyploid cells. FBgn0038472 Alliance Enables ribosome binding activity. Involved in ribosome localization. Acts upstream of with a positive effect on dendrite arborization. Located in cytosol and nucleoplasm. Is expressed in central brain primordium; embryonic brain; larval dorsal multidendritic neurons; organism; and ventral nerve cord primordium. FBgn0038470 Alliance Predicted to enable histone deacetylase binding activity. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. FBgn0038469 Alliance Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Located in egg chorion. Is expressed in spermatozoon. FBgn0051418 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0051419 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0028992 Alliance Involved in establishment or maintenance of polarity of follicular epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; and negative regulation of cell population proliferation. Located in apical part of cell and cytoplasm. Is expressed in adult head and organism. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). FBgn0038505 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Orthologous to human PGC (progastricsin). FBgn0038506 Alliance "Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin)." FBgn0038507 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Orthologous to human PGA3 (pepsinogen A3); PGA4 (pepsinogen A4); and PGA5 (pepsinogen A5). FBgn0038511 Alliance "Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Is expressed in several structures, including adult head; embryonic anal pad; embryonic hypopharynx; epithelium; and gut section." FBgn0000564 FlyBase Gene Snapshot "Eclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis." FBgn0038510 Alliance Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. FBgn0038504 UniProtKB Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation (By similarity). (UniProtKB:Q9VEK6) FBgn0038499 FlyBase Gene Snapshot Brf (Brf) encodes a transcription factor binding protein involved in transcription mediated by RNA polymerase III. FBgn0038498 Alliance "Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in plasma membrane. Is expressed in several structures, including embryonic brain; embryonic stomatogastric nervous system; longitudinal visceral muscle fiber; stomatogastric nervous system primordium; and visceral muscle primordium." FBgn0038516 Alliance "Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval midgut; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to several human genes including PYCR1 (pyrroline-5-carboxylate reductase 1)." FBgn0025571 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of mRNA splicing, via spliceosome. Located in nucleus. Part of precatalytic spliceosome. Orthologous to human SF1 (splicing factor 1)." FBgn0038523 Alliance Predicted to be involved in puparial adhesion. Predicted to be located in adhesive extracellular matrix. Is expressed in adult head and adult heart. FBgn0003375 Alliance Involved in puparial adhesion. Located in adhesive extracellular matrix. Is expressed in adult heart and embryonic/larval salivary gland. FBgn0038524 FlyBase Gene Snapshot "slalom (sll) encodes the first transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), that transfers PAPS from cytosol into the lumen of Golgi. It contributes to the sulfation of glycans and proteins, the regulation of several signaling pathways (Hh, Wingless) mediated by glycosaminoglycans during patterning and morphogenesis, and the determination of the embryonic dorsal/ventral axis." FBgn0038526 Alliance Is expressed in organism. FBgn0012002 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038528 Alliance Is expressed in organism. FBgn0051570 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011945 Alliance Predicted to enable CCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038530 FlyBase Gene Snapshot Attacin-D (AttD) encodes is an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria. FBgn0038531 Alliance Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. Is expressed in chordotonal neurons and spermatozoon. Orthologous to human TCTE1 (t-complex-associated-testis-expressed 1). FBgn0051573 Alliance Predicted to enable CCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051578 Alliance Predicted to enable CCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051579 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051577 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038532 Alliance Predicted to enable ubiquitin binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleus. Orthologous to human WDR86 (WD repeat domain 86) and ZNF106 (zinc finger protein 106). FBgn0051576 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0000063 FlyBase Gene Snapshot Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints. FBgn0038536 Alliance "Predicted to be located in nuclear envelope. Predicted to be active in nuclear membrane. Is expressed in several structures, including embryonic/larval visceral muscle cell; somatic muscle primordium; and visceral muscle primordium. Orthologous to human NRM (nurim)." FBgn0051360 Alliance Is expressed in adult head. FBgn0051249 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be part of tRNA-splicing ligase complex. Is expressed in adult head. Orthologous to human RTRAF (RNA transcription, translation and transport factor)." FBgn0051251 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in nuclear migration and protein folding. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human NUDCD3 (NudC domain containing 3). FBgn0038533 Alliance Predicted to be active in late endosome and lysosomal membrane. Is expressed in adult head and adult heart. Orthologous to human TMEM192 (transmembrane protein 192). FBgn0051575 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051580 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051568 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051569 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051591 Alliance Predicted to enable GUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011994 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011993 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011840 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038527 Alliance Is expressed in organism. FBgn0011944 Alliance Predicted to enable CCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0004554 UniProtKB Component of the pupal cuticle. (UniProtKB:P27781) FBgn0038519 FlyBase Gene Snapshot Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. FBgn0010926 UniProtKB Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (UniProtKB:Q9VEJ2) FBgn0038515 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in adult head and organism. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). FBgn0016650 FlyBase Gene Snapshot "Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors." FBgn0038540 Alliance Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. FBgn0038541 FlyBase Gene Snapshot "Tyramine receptor II (TyrRII) encodes a Tyramine 3 class receptor. When heterologously expressed it shows a high affinity for both tyramine and phenylethylamine, and a lower affinity for a range of other related biogenic amines, in both the inhibition of adenylyl cyclase activity and in the release of calcium from internal stores." FBgn0038545 FlyBase Gene Snapshot pasiflora 1 (pasi1) encodes a septate junction protein involved in endothelial barrier function. FBgn0038552 Alliance Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). FBgn0038551 Alliance "Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of heterochromatin. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium." FBgn0038550 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in fat body/gonad primordium; gonad; and organism." FBgn0038549 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Part of heterochromatin. Is expressed in central brain primordium; organism; and ventral nerve cord primordium." FBgn0038548 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus." FBgn0038546 Alliance "Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Part of Sin3-type complex. Is expressed in several structures, including CNS glial cell; anterior endoderm; embryonic/larval midgut primordium; ganglia; and neuroblasts. Used to study carcinoma. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to several human genes including ING2 (inhibitor of growth family member 2)." FBgn0038542 FlyBase Gene Snapshot Tyramine receptor (TyrR) encodes a Tyramine 2 class receptor. When heterologously expressed it shows a very high specificity for the release of intercellular calcium by tyramine. FBgn0038539 FlyBase Gene Snapshot "Autophagy-related 8b (Atg8b) encodes a ubiquitin-like protein and is a member of the autophagy-related gene family, but does not show a role in autophagy. Atg8b has an abundant testis-specific expression and has roles in the maintenance of sperm motility." FBgn0000477 FlyBase Gene Snapshot "Deoxyribonuclease II (DNaseII) encodes an ubiquitous endonuclease that hydrolyzes DNA without sequence specificity, generating nucleotides with 3'-phosphate. It is localized in lysosomes, and essential for degrading nuclear DNA of the engulfed apoptotic cells. DNase II is also responsible to digest mitochondrial DNA during autophagy." FBgn0038564 Alliance Is expressed in adult head; embryonic/larval central nervous system; l-LNv neurons; and organism. Orthologous to human SPRYD7 (SPRY domain containing 7). FBgn0038565 Alliance Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Is expressed in organism. FBgn0038566 Alliance "Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including antennal anlage; antennal primordium; anterior endoderm anlage; head epidermis primordium; and mesoderm." FBgn0003499 FlyBase Gene Snapshot "stripe (sr) encodes a transcription factor that induces the fate of tendon cells in the embryo as well as in the adult fly. It works upstream of tendon specific genes including Tsp, slow and Lrt." FBgn0051242 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051518 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038567 Alliance Predicted to be active in cytoplasm. FBgn0010389 FlyBase Gene Snapshot heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives. FBgn0022943 UniProtKB "Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. (UniProtKB:Q9V3L6)" FBgn0042693 FlyBase Gene Snapshot well-rounded (wrd) encodes one of the two regulatory B' subunits of the protein phosphatase PP2A. It influences metabolism and growth via negative regulation of the InR/TOR signalling network. FBgn0038576 UniProtKB "Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (UniProtKB:Q9VEC3)" FBgn0038578 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. Negatively regulates sex comb development. (UniProtKB:Q9VEC1)" FBgn0028499 Alliance Predicted to enable beta-N-acetylhexosaminidase activity. Located in mitochondrion. Is expressed in adult brain cell body rind; adult head; adult optic lobe; lamina; and photoreceptor cell R7. Orthologous to human HEXD (hexosaminidase D). FBgn0038581 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in embryonic central brain neurons; embryonic/larval nervous system; ganglia; lateral cord neurons; and ventral midline of embryo. FBgn0038582 UniProtKB Possible regulator involved in a circadian clock input pathway. (UniProtKB:Q9VEB5) FBgn0038585 UniProtKB Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs. (UniProtKB:Q9VEB3) FBgn0011701 FlyBase Gene Snapshot reversed polarity (repo) encodes a homeodomain transcription factor specifically expressed in glial cells. It is is a direct target of the pan-glial fate determinant encoded by gcm and is required for acquisition of glial fate and subsequent terminal glial differentiation. FBgn0020238 FlyBase Gene Snapshot "14-3-3epsilon (14-3-3epsilon) encodes an acidic protein that preferentially heterodimerizes with other members of the family but also can homodimerize. It functions in multiple signaling pathways, most prominently in the Ras/MAPK cascade. It is involved in embryonic hatching, germ cell migration, gonad formation, wing venation and eye development." FBgn0038592 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; cuboidal/columnar epithelium; embryonic/larval nervous system; ganglia; and mushroom body primordium. Orthologous to human NOTO (notochord homeobox)." FBgn0026250 FlyBase Gene Snapshot "eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition." FBgn0038597 Alliance "Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and hindgut proper primordium. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human WDR3 (WD repeat domain 3)." FBgn0024432 FlyBase Gene Snapshot Dynein light chain 90F (Dlc90F) encodes a light chain subunit of the cytoplasmic dynein complex. The product of Dlc90F forms a dimer that assembles into the cytoplasmic dynein complex and is thought to link dynein to cargos and to adapter proteins that regulate dynein motor function. It contributes to male fertility. FBgn0038607 UniProtKB Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs. (UniProtKB:Q9VE87) FBgn0038609 Alliance Involved in mitotic cell cycle. Predicted to be part of nuclear pore outer ring. Is expressed in organism. Used to study candidiasis. Orthologous to human NUP43 (nucleoporin 43). FBgn0038611 Alliance Predicted to be active in extracellular matrix and extracellular space. Is expressed in embryonic/larval midgut; embryonic/larval muscle system; and organism. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to several human genes including HPSE (heparanase). FBgn0038610 Alliance "Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; gut section; and synaptic neuropil domain. Orthologous to human RDH14 (retinol dehydrogenase 14)." FBgn0038608 FlyBase Gene Snapshot "WRN exonuclease (WRNexo) encodes a 3'-5' exonuclease that cleaves 3' ends of both single-stranded and duplex DNA substrates that resemble DNA structures present during DNA replication. It may act in concert with RecQ family helicases to resolve Holliday junctions or other unusual DNA structures. It is likely to be involved in DNA replication, recombination and repair, and is essential for early embryonic development." FBgn0038606 Alliance Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component). FBgn0038603 FlyBase Gene Snapshot Protein Kinase D (PKD) encodes a Ser/Thr kinase of the PKC family of Ca[2+]/calmodulin-dependent protein kinases. It regulates actin-dynamics by controlling the activity of the phosphatase encoded by ssh. FBgn0038601 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and transcription elongation by RNA polymerase I. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including antennal anlage; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Orthologous to human POLR1E (RNA polymerase I subunit E)." FBgn0010877 Alliance "Predicted to be involved in actin filament organization and cell migration. Is expressed in several structures, including anterior endoderm anlage; central brain primordium; dorsal epidermis primordium; ganglia; and mesoderm." FBgn0038598 Alliance Predicted to enable microtubule binding activity. Predicted to be active in microtubule cytoskeleton and sperm flagellum. Is expressed in adult head and spermatozoon. Orthologous to human SAXO1 (stabilizer of axonemal microtubules 1) and SAXO2 (stabilizer of axonemal microtubules 2). FBgn0038596 Alliance Is expressed in adult head. FBgn0038595 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0038593 FlyBase Gene Snapshot Vacuolar protein sorting 39 (Vps39) encodes a subunit of the homotypic fusion and vacuole protein sorting (HOPS) complex required for autophagosome maturation. FBgn0038590 Alliance Predicted to be involved in spliceosomal tri-snRNP complex assembly. Located in cytoplasm. Part of small nuclear ribonucleoprotein complex. Orthologous to human AAR2 (AAR2 splicing factor). FBgn0038588 Alliance "Predicted to enable protein serine/threonine kinase activity. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium. Orthologous to several human genes including RPS6KC1 (ribosomal protein S6 kinase C1)." FBgn0038586 Alliance Is expressed in adult head and organism. Orthologous to human COMMD2 (COMM domain containing 2). FBgn0038584 FlyBase Gene Snapshot mitochondrial transcription termination factor 5 (mTerf5) encodes a protein that regulates mitochondrial DNA transcription and replication by relieving the block exerted by the DNA binding factor encoded by mTTF. Both proteins cooperate in coordinating the passage of transcription and replication complexes that move on opposite DNA strands. FBgn0038583 Alliance Predicted to be active in nucleus. Orthologous to human CCDC174 (coiled-coil domain containing 174). FBgn0011481 FlyBase Gene Snapshot Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. FBgn0038577 Alliance Predicted to be involved in proteasome assembly. Predicted to be active in cytosol and nucleus. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 4. Orthologous to human PSMG2 (proteasome assembly chaperone 2). FBgn0038569 Alliance Predicted to be involved in positive regulation of cilium assembly. Predicted to be active in ciliary basal body and endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human TAPT1 (transmembrane anterior posterior transformation 1). FBgn0038612 FlyBase Gene Snapshot "corona (cona) encodes a component of the synaptonemal complex that is required for many meiotic processes, including homolog pairing, recombination, and chromosome segregation at meiosis I." FBgn0038619 Alliance Predicted to be involved in N-glycan processing. Predicted to be part of glucosidase II complex. Is expressed in adult head. FBgn0038626 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus." FBgn0038627 UniProtKB E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (UniProtKB:Q9VE61) FBgn0038630 Alliance Enables protein serine/threonine kinase activity. Involved in spermatogenesis. Located in nucleus. Is expressed in adult head and testis. Orthologous to several human genes including TSSK2 (testis specific serine kinase 2). FBgn0023083 FlyBase Gene Snapshot "frayed (fray) encodes a serine/threonine-protein kinase required for axonal ensheathment. It is activated via phosphorylation by the kinase encoded by Wnk. The product of fray contributes to regulating ion transport, canonical Wnt signaling and asymmetric cell division." FBgn0038629 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0004652 FlyBase Gene Snapshot fruitless (fru) encodes a BTB zinc finger transcription factor that contributes to sexual differentiation of the neural circuits underlying male sexual behavior. FBgn0051122 Alliance "Predicted to be active in mitochondrion. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 53. Orthologous to human C2orf69 (chromosome 2 open reading frame 69)." FBgn0038621 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). FBgn0038617 Alliance Is expressed in adult head and organism. Used to study neurooculocardiogenitourinary syndrome. Human ortholog(s) of this gene implicated in neurooculocardiogenitourinary syndrome. Orthologous to human WDR37 (WD repeat domain 37). FBgn0028670 Alliance "Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult copper cell; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; and renal tubular acidosis. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1) and ATP6V0A4 (ATPase H+ transporting V0 subunit a4)." FBgn0038613 Alliance "Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in plasma membrane. Is expressed in adult head; copper cell primordium; dorsal epidermis primordium; embryonic/larval midgut; and prothoracic gland. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4)." FBgn0044871 FlyBase Gene Snapshot "Golgi SNARE, 28 kDa (Gos28) encodes a protein involved in vesicular protein trafficking. It functions as a t-SNARE in medial- to trans-Golgi transport of rhodopsin during its biosynthesis." FBgn0051229 UniProtKB "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). (UniProtKB:Q8IN78)" FBgn0038638 Alliance "Predicted to be active in membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; embryonic/larval muscle system; and gut section." FBgn0038640 Alliance Predicted to enable mRNA binding activity. Orthologous to human SLC4A1AP (solute carrier family 4 member 1 adaptor protein). FBgn0038641 UniProtKB Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). (UniProtKB:Q9VE46) FBgn0038653 Alliance "Enables octopamine receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult central nervous system; adult octopaminergic neurons; antennal lobe; and organism subdivision. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; artery disease (multiple); attention deficit hyperactivity disorder; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A); ADRA2B (adrenoceptor alpha 2B); and ADRA2C (adrenoceptor alpha 2C)." FBgn0038652 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in adult head; embryonic dorsal epidermis; embryonic large intestine; embryonic ventral epidermis; and large intestine primordium. FBgn0038649 Alliance "Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1)." FBgn0024329 FlyBase Gene Snapshot "Mekk1 (Mekk1) encodes a MAP kinase kinase kinase that regulates the stress response. It is required for resistance to several stresses, notably osmotic shock, and for the regulation of the activity of the product of Duox." FBgn0038646 Alliance Predicted to enable chitin binding activity. Is expressed in embryonic foregut; embryonic proventriculus; and organism. FBgn0038645 Alliance Predicted to enable chitin binding activity. Is expressed in adult midgut progenitor cell; embryonic midgut chamber; embryonic proventriculus; and embryonic/larval midgut. FBgn0038642 Alliance Predicted to enable transcription coactivator activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular matrix. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adult head; embryonic/larval tracheal section; and organism. FBgn0038632 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0051228 Alliance Predicted to enable CCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038631 Alliance Is expressed in adult fat body; antennal disc; eye disc; leg disc; and wing disc. FBgn0038654 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0038655 Alliance "Predicted to enable protein tyrosine phosphatase activity. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1)." FBgn0003248 FlyBase Gene Snapshot "Rhodopsin 2 (Rh2) encodes a light sensitive GPCR Rhodopsin protein that activates the phototransduction cascade and leads to photoreceptor depolarization. It responds to a broad spectrum of wavelengths of light and is exclusively expressed in the ocelli, which are likely involved in horizon detection." FBgn0038659 FlyBase Gene Snapshot Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes. FBgn0022338 UniProtKB "Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, 2'-deoxyriboadenosine, 2'-deoxyribocytidine and 2'-deoxyriboguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated. (UniProtKB:Q9XZT6)" FBgn0038673 Alliance Orthologous to human C8orf33 (chromosome 8 open reading frame 33). FBgn0027785 Alliance Predicted to be involved in respiratory electron transport chain. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11). FBgn0015781 Alliance Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in adult head; embryonic/larval garland cell; and organism. FBgn0038675 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in adult head and organism. Orthologous to human CCDC124 (coiled-coil domain containing 124). FBgn0038676 Alliance Predicted to enable transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. FBgn0004876 FlyBase Gene Snapshot center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr. FBgn0027784 Alliance Predicted to be involved in generation of catalytic spliceosome for second transesterification step. Predicted to be part of U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Is expressed in organism. Orthologous to human PRPF18 (pre-mRNA processing factor 18). FBgn0038672 Alliance Predicted to enable phosphatidylinositol 3-kinase regulator activity. Involved in wound healing. Predicted to be active in early endosome membrane and late endosome membrane. Is expressed in organism. Orthologous to human WDR91 (WD repeat domain 91). FBgn0038666 FlyBase Gene Snapshot Smu1 spliceosomal factor (Smu1) encodes a spliceosomal protein required for normal neuromuscular junction development and function. It functions together with the product of beag. Both proteins can regulate synaptic levels of the product of Fas2. FBgn0038665 Alliance Predicted to be active in cytosol. FBgn0038662 FlyBase Gene Snapshot "Mitochondrial pyruvate carrier (Mpc1) encodes an obligate subunit of the mitochondrial pyruvate carrier, which transports pyruvate across the mitochondrial inner membrane." FBgn0038660 Alliance "Predicted to enable N-sulfoglucosamine sulfohydrolase activity. Predicted to be involved in glycosaminoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Is expressed in several structures, including antennal primordium; anterior-posterior subdivision of organism; cuboidal/columnar epithelium; head epidermis primordium; and sense organ. Used to study mucopolysaccharidosis type IIIA. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase)." FBgn0038658 Alliance Is expressed in adult head. FBgn0038656 Alliance Is expressed in adult head. FBgn0016120 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. (UniProtKB:Q24251)" FBgn0038679 Alliance "Is expressed in several structures, including embryonic hypopharynx; embryonic large intestine; embryonic ventral epidermis; epidermis; and gut section." FBgn0038680 Alliance "Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1)." FBgn0038681 UniProtKB "Has a role in resistance to insecticide lufenuron, but no other insecticides. (UniProtKB:Q9VE00)" FBgn0002962 FlyBase Gene Snapshot "nanos (nanos) encodes an RNA-binding protein that forms part of a translational repressor complex. It functions as the localized determinant of abdominal segmentation. It contributes to germline development, germline stem cell renewal, and neuronal morphogenesis and function." FBgn0010768 FlyBase Gene Snapshot squeeze (sqz) encodes a transcription factor that regulates neuropeptidergic cellular identity and axon/dendrite pathfinding. FBgn0038685 Alliance Predicted to be part of Set1C/COMPASS complex. Is expressed in spermatozoon. FBgn0051475 Interactive Fly calcium ion binding protein - maintenance of synapse structure - has a positive effect on retrograde trans-synaptic BMP signaling - active in trans-Golgi network - orthologous to human SDF4 (stromal cell derived factor 4). FBgn0025680 UniProtKB "Blue light-dependent regulator that is the input of the circadian feedback loop (PubMed:10063806, PubMed:10233998, PubMed:10417378, PubMed:16527739, PubMed:17298948, PubMed:18597555, PubMed:36994075, PubMed:9845369). Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts (PubMed:10063806). Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms (PubMed:10063806, PubMed:10233998, PubMed:9845369). Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells (PubMed:10417378, PubMed:16527739, PubMed:36994075, PubMed:9845370). Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry (PubMed:10417378, PubMed:16527739). Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate (PubMed:18641630). Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing (PubMed:18641630). (UniProtKB:O77059)" FBgn0038692 Alliance "Predicted to enable transcription elongation factor activity. Predicted to be involved in transcription elongation by RNA polymerase II. Part of RNA polymerase II, core complex. Orthologous to human POLR2M (RNA polymerase II subunit M)." FBgn0000463 FlyBase Gene Snapshot "Delta (Delta) encodes a single pass transmembrane EGF family protein and one of two ligands of the Notch signaling pathway. It regulates cell fate decisions and cell proliferation. Post transcriptional modification (such as by fucosylation, ubiquitination and proteolysis) of the product of Delta is key for its functions." FBgn0038694 Alliance Is expressed in adult head. FBgn0038693 FlyBase Gene Snapshot uncoordinated 79 (unc79) encodes a protein involved in circadian locomotor rhythms. FBgn0038691 Alliance Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be part of sodium:potassium-exchanging ATPase complex. FBgn0038690 Alliance Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in adult head. FBgn0038686 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in Ras protein signal transduction and protein ubiquitination. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human BRAP (BRCA1 associated protein). FBgn0038678 FlyBase Gene Snapshot mitochondrial ribosomal protein L55 (mRpL55) encodes a protein involved in mitochondrial biogenesis and cell division. FBgn0038700 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head; embryonic hindgut; embryonic/larval midgut; larval foregut atrium; and spermatozoon. FBgn0038701 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head and embryonic/larval midgut. FBgn0038702 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0038704 UniProtKB "DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). (UniProtKB:Q8MSG8)" FBgn0038705 Alliance Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. FBgn0038708 Alliance Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming). Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). FBgn0038706 Alliance Is expressed in spermatozoon. FBgn0051244 Alliance Enables protein phosphatase 1 binding activity. Predicted to be active in mitochondrion. FBgn0038697 Alliance Is expressed in spermatozoon. FBgn0038715 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0038716 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A23 (solute carrier family 22 member 23). FBgn0038718 Alliance "Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in plasma membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval fat body; embryonic/larval midgut primordium; and germline cell. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12)." FBgn0038719 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A24 (solute carrier family 22 member 24). FBgn0038722 UniProtKB "Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (PubMed:15086791). Together with Nup54, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346). By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346). (UniProtKB:Q9VDV3)" FBgn0051220 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0051219 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0003011 FlyBase Gene Snapshot ora transientless (ort) encodes an ionotropic histamine-gated chloride channel required for vision. It is essential in the first-order interneurons to receive histaminergic inputs from the photoreceptors. In the central brain the product of ort modulates preference and tolerance for high and low temperature. FBgn0038727 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic epipharynx; embryonic/larval posterior spiracle; and labral segment. FBgn0051216 FlyBase Gene Snapshot "Nicotinamide amidase (Naam) encodes a nicotinamidase involved in lifespan determination, neuron apoptosis regulation and response to oxidative stress." FBgn0038732 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. FBgn0038733 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in adult head and yolk nucleus. FBgn0038734 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in embryonic epipharynx; embryonic hindgut; and embryonic/larval midgut. FBgn0012004 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051215 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051471 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038731 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in embryonic hindgut; embryonic precursor of adult hindgut; and yolk nucleus. FBgn0038730 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in embryonic hindgut; embryonic precursor of adult hindgut; and yolk nucleus. FBgn0012003 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038725 Alliance Is expressed in adult head. Orthologous to human FAM234B (family with sequence similarity 234 member B). FBgn0038723 Alliance Predicted to enable GTP binding activity. Predicted to be involved in cytoplasmic translation. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). FBgn0038721 FlyBase Gene Snapshot subdued (subdued) encodes a chloride ion channel activated by calcium and heat belonging to the TMEM16 family. Its roles include host defense against ingested pathogenic bacteria and modulation of sensory neuronal signaling. FBgn0038720 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0038735 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. Is expressed in adult head. Orthologous to several human genes including MICU3 (mitochondrial calcium uptake family member 3). FBgn0038737 UniProtKB "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1579 (Um1579) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1580 (Gm1580) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function. (UniProtKB:Q9VDT6)" FBgn0038739 Alliance Predicted to be active in membrane. Is expressed in adult head; adult heart; eye; and spermatozoon. Orthologous to human TMEM256 (transmembrane protein 256). FBgn0038742 Alliance "Predicted to enable butyryl-CoA dehydrogenase activity. Predicted to be involved in butyrate catabolic process and fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in alcohol use disorder and short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain)." FBgn0014006 FlyBase Gene Snapshot "Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses." FBgn0038744 FlyBase Gene Snapshot "CG4733 encodes a protein that is predicted to be the B""/PR72 subunit of Protein Phosphatase 2A (PP2A) regulatory B unit. The B subunits determine the substrate specificity of the enzyme." FBgn0038747 UniProtKB GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (UniProtKB:Q9VDS5) FBgn0038751 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. FBgn0051213 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0038760 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9VDR1)" FBgn0038766 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including CNS glial cell; central brain primordium; mesoderm; and ventral nerve cord primordium." FBgn0038768 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism." FBgn0038772 FlyBase Gene Snapshot midlife crisis (mdlc) encodes a nuclear protein that is required for maintaining neuronal differentiation. FBgn0038771 Alliance Enables serine hydrolase activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be active in cytosol. Is expressed in organism. Orthologous to human ESD (esterase D). FBgn0038769 Alliance Predicted to enable RNA endonuclease activity and mRNA binding activity. Involved in mRNA catabolic process and miRNA catabolic process. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to several human genes including ZC3H12A (zinc finger CCCH-type containing 12A); ZC3H12B (zinc finger CCCH-type containing 12B); and ZC3H12C (zinc finger CCCH-type containing 12C). FBgn0038767 FlyBase Gene Snapshot trade embargo (trem) encodes a chromatin-associated zinc-finger protein required to initiate programmed meiotic double-strand break formation. FBgn0038765 Alliance Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism. FBgn0038763 Alliance Predicted to enable N-acetylglucosaminylphosphatidylinositol deacetylase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in CHIME syndrome. Orthologous to human PIGL (phosphatidylinositol glycan anchor biosynthesis class L). FBgn0038755 FlyBase Gene Snapshot "Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways." FBgn0021776 FlyBase Gene Snapshot "miranda (mira) encodes a cytoplasmic and cortical scaffolding protein that binds the products of pros, stau and brat. It is asymmetrically localized to the basal cortex during neuroblast asymmetric cell division, resulting in its partioning into GMC daughter cells, where it is degraded and releases its cargo proteins." FBgn0038753 Alliance Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in plasma membrane. Orthologous to human SLC22A15 (solute carrier family 22 member 15). FBgn0038752 Alliance Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in plasma membrane. Is expressed in adult head and seminal receptacle. Orthologous to human SLC22A15 (solute carrier family 22 member 15). FBgn0038750 Alliance Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in plasma membrane. Orthologous to human SLC22A15 (solute carrier family 22 member 15). FBgn0038749 FlyBase Gene Snapshot exit protein of rhodopsin and TRP A (Xport-A) encodes a TRP channel chaperone. It mediates the transport to the plasma membrane of the products of ninaE and trp. FBgn0038746 UniProtKB Involved in a nucleolar function. (UniProtKB:Q9VDS6) FBgn0038745 Alliance Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in proteolysis involved in protein catabolic process and regulation of mitochondrial gene expression. Part of endopeptidase Clp complex. Is expressed in adult heart; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). FBgn0002940 FlyBase Gene Snapshot "neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization." FBgn0038740 Alliance Enables ABC-type heme transporter activity. Involved in heme export. Located in plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0038738 Alliance Enables serine hydrolase activity. Involved in dsRNA transport. Is expressed in adult head; adult heart; organism; and spermatozoon. Orthologous to human CPVL (carboxypeptidase vitellogenic like). FBgn0038773 Alliance Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. FBgn0045471 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IN58)" FBgn0038774 Alliance Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to be active in actin cytoskeleton. Is expressed in adult head; adult heart; and embryonic/larval muscle system. Orthologous to human TAGLN (transgelin); TAGLN2 (transgelin 2); and TAGLN3 (transgelin 3). FBgn0038775 Alliance Predicted to enable oxidoreductase activity. FBgn0003249 FlyBase Gene Snapshot Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. FBgn0038788 FlyBase Gene Snapshot "Sirtuin 2 (Sirt2) encodes an NAD-dependent histone deacetylase in the class I of the Sirtuin family. It is involved in protein deacetylation, determination of adult lifespan, and neurodegeneration." FBgn0038789 FlyBase Gene Snapshot Ionotropic receptor 92a (Ir92a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of ammonia and amines to mediate attraction behavior. FBgn0038790 FlyBase Gene Snapshot Metallothionein C (MtnC) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1. FBgn0038796 UniProtKB "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (UniProtKB:Q9VDM6)" FBgn0038798 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:Q9VDM1)" FBgn0038799 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in adult head; embryonic/larval hindgut; embryonic/larval posterior spiracle; and embryonic/larval salivary gland. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). FBgn0002869 FlyBase Gene Snapshot "Metallothionein B (MtnB) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnB shows a preference towards divalent metal ion binding." FBgn0038797 Alliance "Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; phosphate ion transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10)." FBgn0038795 Alliance "Predicted to enable trimethyllysine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TMLHE (trimethyllysine hydroxylase, epsilon)." FBgn0038787 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF355P (zinc finger protein 355, pseudogene)." FBgn0053192 FlyBase Gene Snapshot Metallothionein D (MtnD) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1. FBgn0043457 Alliance Is expressed in organism; wing hinge primordium; and wing pouch. FBgn0038803 Alliance Predicted to enable acylglycerol lipase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Is expressed in adult head. FBgn0038806 Alliance Enables serine hydrolase activity. Predicted to be involved in response to retinoic acid. Predicted to be active in cytoplasm and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). FBgn0038808 Alliance "Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to be involved in protein targeting to ER. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in organism. Orthologous to human SRP14 (signal recognition particle 14)." FBgn0038810 Alliance "Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Involved in dsRNA transport. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in adult head and adult heart. Orthologous to human SRP72 (signal recognition particle 72)." FBgn0023097 FlyBase Gene Snapshot bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization. FBgn0001169 FlyBase Gene Snapshot "Hairless (H) encodes the major antagonist of Notch signaling activity during imaginal development. It silences target genes of the product of N by assembling a transcriptional repressor complex, which includes the transcription factor encoded by Su(H) and general co-repressors like those encoded by gro and CtBP." FBgn0038816 FlyBase Gene Snapshot "Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response." FBgn0038819 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head. FBgn0051205 Alliance Predicted to be involved in proteolysis. Is expressed in adult fat body. FBgn0004107 FlyBase Gene Snapshot "Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles." FBgn0051200 Alliance Predicted to be involved in proteolysis. Is expressed in adult head and embryonic brain. FBgn0051199 Alliance Predicted to be involved in proteolysis. Is expressed in adult head. FBgn0024944 UniProtKB "Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates (PubMed:15816867, PubMed:9570796). Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding (PubMed:15816867, PubMed:9570796). Required for ovulation (PubMed:14623240, PubMed:19262750). Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation (PubMed:26473732). Ligand binding probably also leads to activation of CamKII which is also required for ovulation (PubMed:19262750). Modulates sleep/wake behavior by acting in neurons of the pars intercerebralis to promote wakefulness (PubMed:20223202). Plays a role in courtship conditioning where the courtship behavior of males rejected by already mated females is inhibited with further females (PubMed:23055498). Required in the mushroom body for appetitive olfactory learning (PubMed:23103875, PubMed:23345239). Specifically conveys the short-term reinforcing effects of sweet taste (PubMed:23103875, PubMed:25728694). In insulin-producing cells of the brain, plays a role in inhibiting transcription of insulin-like peptide Ilp3 (PubMed:24923784). Also plays a role in social behavior by modulating male agression (PubMed:24923784). (UniProtKB:Q7JQF1)" FBgn0038820 Alliance Is expressed in organism. FBgn0038818 FlyBase Gene Snapshot Neprilysin 4 (Nep4) encodes a metallopeptidase considered to cleave and thus inactivate signaling peptides in the extracellular space. It contributes to muscle integrity and male fertility. FBgn0028422 FlyBase Gene Snapshot Glutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. FBgn0051201 FlyBase Gene Snapshot Glutamate receptor IIE (GluRIIE) encodes an ion channel subunit involved in calcium ion transport. FBgn0015279 FlyBase Gene Snapshot "Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth." FBgn0038814 Alliance "Predicted to be involved in cilium assembly. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. Is expressed in adult brain. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67)." FBgn0051506 Alliance Predicted to enable UUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038811 Alliance "Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1)." FBgn0014029 UniProtKB Involved in cytokinesis. (UniProtKB:P54359) FBgn0038809 Alliance "Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; and ganglia." FBgn0023212 FlyBase Gene Snapshot "Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. The proteins encoded by EloB and EloC form an adaptor subcomplex of a Cul2-RING ubiquitin ligase complex." FBgn0038805 FlyBase Gene Snapshot "mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA." FBgn0038804 Alliance Predicted to enable succinate-hydroxymethylglutarate CoA-transferase activity. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in glutaric acidemia type 3. Orthologous to human SUGCT (succinyl-CoA:glutarate-CoA transferase). FBgn0040575 Alliance Is expressed in adult head. FBgn0038826 FlyBase Gene Snapshot Syncrip (Syp) encodes an RNA-binding protein that regulates the localization and translation of mRNAs involved in multiple processes. It is required for synapse morphology and synaptic transmission at the neuromuscular junction as well as being involved in oocyte axis specification and control of neuronal cell fates in the mushroom body. FBgn0019936 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPS20 (ribosomal protein S20). FBgn0051223 Alliance Orthologous to human ZNHIT2 (zinc finger HIT-type containing 2). FBgn0053094 Interactive Fly "F-BAR-domain containing protein that regulates cellularization, membrane tubulation, Clathrin-mediated and bulk endocytosis, formation of subsynaptic reticulum and F-actin stability, contributes to coupling the plasma membrane and contractile ring in cytokinesis" FBgn0038832 Alliance Is expressed in adult head; embryonic/larval midgut interstitial cell; embryonic/larval plasmatocyte; and plasmatocyte primordium. FBgn0038833 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium." FBgn0038834 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in adult head; adult heart; and organism. Orthologous to human FAU (FAU ubiquitin like and ribosomal protein S30 fusion). FBgn0028396 FlyBase Gene Snapshot Turandot A (TotA) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. FBgn0044812 FlyBase Gene Snapshot Turandot C (TotC) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. FBgn0038838 FlyBase Gene Snapshot Turandot B (TotB) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. FBgn0044809 FlyBase Gene Snapshot Turandot Z (TotZ) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. FBgn0051480 Alliance Predicted to enable ACG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051334 Alliance Predicted to enable ACG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051333 Alliance Predicted to enable ACG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038840 Alliance Predicted to enable kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and regulation of synaptic activity. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult CNS glial cell; adult brain; adult head; and transmedullary neuron Tm5c. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). FBgn0038842 Alliance "Involved in negative regulation of female receptivity, post-mating. Is expressed in adult heart." FBgn0051191 Alliance Is expressed in adult head; wing hinge primordium; and wing pouch. FBgn0044810 FlyBase Gene Snapshot Turandot X (TotX) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. FBgn0038839 FlyBase Gene Snapshot Kctd12-like (Ktl) encodes a protein involved in male aggression and mating behavior. FBgn0038837 Interactive Fly glutamate channel - kainate family protein - localized to presynaptic terminals of the neuromuscular junction - eya - homeostatic potentiation of synaptic strength FBgn0027493 FlyBase Gene Snapshot Adenylosuccinate synthetase (Adss) encodes a protein involved in purine nucleotide biosynthesis and neurogenesis. FBgn0038830 Alliance "Predicted to enable calcium ion binding activity and enzyme regulator activity. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; and gut section. Orthologous to human CALML4 (calmodulin like 4)." FBgn0038829 Alliance "Predicted to enable calcium ion binding activity. Involved in sexual reproduction. Predicted to be located in extracellular space. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; embryonic dorsal epidermis; and gland. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit)." FBgn0038828 Alliance Predicted to enable protein-macromolecule adaptor activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human ERG28 (ergosterol biosynthesis 28 homolog). FBgn0038827 UniProtKB "Together with Fancl, and probably FANCI, involved in DNA repair of damage caused by agents that induce interstrand cross-links but not agents that cause double strand breaks (PubMed:16860002, PubMed:20154706). Required for S phase checkpoint activation in response to ionizing radiation induced DNA damage (PubMed:16860002). (UniProtKB:Q8MYL1)" FBgn0046689 Alliance Predicted to enable protein kinase activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. FBgn0051195 Alliance Located in plasma membrane. Is expressed in adult head and adult heart. FBgn0013995 FlyBase Gene Snapshot Na/Ca-exchange protein (Calx) encodes a Na-Ca exchanger involved in phototransduction and response to endoplasmic reticulum stress. FBgn0026056 FlyBase Gene Snapshot Ral interacting protein (Rlip) encodes a Rho GTPase activating protein involved in receptor-mediated endocytosis. FBgn0038851 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to be active in nucleus. Is expressed in embryonic frontal ganglion. Used to study primary ovarian insufficiency. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3)." FBgn0038855 Alliance Predicted to enable GTPase activator activity. Located in cytosol. Is expressed in organism. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). FBgn0028468 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in brush border membrane. Is expressed in embryonic anal pad; embryonic foregut; embryonic head epidermis; embryonic hindgut; and organism. Orthologous to human MFSD10 (major facilitator superfamily domain containing 10). FBgn0015790 FlyBase Gene Snapshot "Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions." FBgn0010770 UniProtKB Required for initiation of larval growth and normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Required for progression of normal oogenesis and maturation of some imaginal tissues into adult structures. (UniProtKB:Q9VDE5) FBgn0038858 Alliance Predicted to enable acetylpyruvate hydrolase activity. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human FAHD1 (fumarylacetoacetate hydrolase domain containing 1). FBgn0038860 UniProtKB "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. (UniProtKB:Q8SZZ8)" FBgn0038862 FlyBase Gene Snapshot Ubiquitin specific protease 8 (Usp8) encodes a protease involved in protein deubiquitination. It contributes to the integrity of ESCRT sorting machinery and the regulation of Hedgehog and Wingless signaling pathways. FBgn0038865 Alliance "Orthologous to human NRROS (negative regulator of reactive oxygen species) and TSKU (tsukushi, small leucine rich proteoglycan)." FBgn0038861 UniProtKB "Methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:31943105). May require WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:31943105). Plays a role in neurogenesis (PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:31943105). Modifies position 34 in tRNA(Leu(CAA)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), and tRNA(Trp(CCA)) (PubMed:31943105). (UniProtKB:Q9VDD9)" FBgn0038859 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0038857 FlyBase Gene Snapshot Bride of doubletime (Bdbt) encodes a protein that binds to a nuclear localization signal in the product of dco and is necessary for normal circadian dco activity on the product of per. The product of Bdbt also accumulates in cytosolic foci in photoreceptors during the middle of the night. FBgn0038854 Alliance "Predicted to be involved in DNA damage response and positive regulation of protein phosphorylation. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human BRAT1 (BRCA1 associated ATM activator 1)." FBgn0038853 Alliance Enables GTPase activator activity. Involved in axon midline choice point recognition. Located in cytoplasm. Is expressed in adult fat body; adult head; and leg. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). FBgn0038852 FlyBase Gene Snapshot Hematopoietically expressed homeobox (HHEX) encodes a transcription factor involved in response to sucrose. FBgn0003257 FlyBase Gene Snapshot rudimentary-like (r-l) encodes an enzyme involved in the novo pyrimidine biosynthesis. FBgn0025865 Interactive Fly "cytoskeletal component that acts as a link, via Src, between surface receptors and actin - interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex" FBgn0038850 Alliance Predicted to be active in extracellular space. FBgn0038849 Alliance Predicted to be active in extracellular space. Is expressed in adult fat body. FBgn0051207 Alliance Predicted to be active in extracellular space. Is expressed in adult head and organism. FBgn0051189 Alliance Predicted to be active in extracellular space. Is expressed in adult fat body. FBgn0013812 FlyBase Gene Snapshot Dynein heavy chain at 93AB (Dhc93AB) encodes a motor protein involved in hearing. FBgn0046763 FlyBase Gene Snapshot pegasus (peg) encodes a secreted Kazal-type serine protease whose expression is induced by bacterial infection. RNAi results in lethality and wing adhesion defects. FBgn0038845 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in adult head. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0038868 UniProtKB "Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins. (UniProtKB:Q9VDD1)" FBgn0038870 FlyBase Gene Snapshot "O-GlcNAcase (Oga) encodes a protein that, together with the product of sxc, is responsible for O-GlcNAcylation. O-GlcNAcylation is a dynamic post-translational modification that modifies serine and threonine residues of proteins, and plays important roles in biological functions such as metabolism and neurodegeneration." FBgn0038873 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0038874 FlyBase Gene Snapshot "ETHR (ETHR) encodes two distinct G protein-coupled receptors through alternative splicing. During development, the receptors are essential in initiating the molt-related behaviors of ecdysis, and in adults they function to promote juvenile hormone signaling and reproduction." FBgn0038876 Alliance Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including IDI2 (isopentenyl-diphosphate delta isomerase 2). FBgn0001234 FlyBase Gene Snapshot "Heat shock RNA omega (lncRNA:Hsromega) is a developmentally expressed and stress-inducible long non-coding RNA gene, producing multiple nuclear and cytoplasmic transcripts. The long nuclear transcripts, in association with various heterogeneous nuclear ribonucleoproteins (hnRNPs), organize nucleoplasmic omega speckles to regulate multiple cellular processes." FBgn0002781 FlyBase Gene Snapshot "modifier of mdg4 (mod(mdg4)) encodes a nuclear protein that specifically interacts with various DNA binding proteins. It is involved in processes including chromosome condensation and segregation, regulation of transcription and enhancer blocking." FBgn0004110 FlyBase Gene Snapshot tinman (tin) encodes a homeodomain transcription factor involved in the formation of the heart and dorsal vascular musculature. FBgn0004862 FlyBase Gene Snapshot "bagpipe (bap) encodes an important homeodomain transcription factor for visceral mesoderm formation, which differentiates into gut musculature." FBgn0038887 Alliance "Predicted to enable RNA cap binding activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of nuclear cap binding activity complex. Predicted to be active in nucleus." FBgn0011278 FlyBase Gene Snapshot ladybird early (lbe) encodes a transcription factor involved in muscle and heart development. It also plays a role in regulating the embryonic expression of wg. FBgn0008651 FlyBase Gene Snapshot ladybird late (lbl) encodes a transcription factor involved in muscle and heart development. It also plays a role in regulating the embryonic expression of wg. FBgn0038881 FlyBase Gene Snapshot argus (aus) encodes a protein required for one or more steps of mature autophagosome degradation. Loss of its autophagy function results in sleep loss. FBgn0038878 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult head. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0038877 Alliance Predicted to enable single-stranded DNA 3'-5' DNA exonuclease activity. Predicted to be active in cytosol. Is expressed in spermatozoon. FBgn0043012 FlyBase Gene Snapshot "Adaptor Protein complex 2, sigma subunit (AP-2sigma) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization." FBgn0000527 FlyBase Gene Snapshot "ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity." FBgn0038871 Alliance Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in regulation of mitochondrial ATP synthesis coupled proton transport. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to several human genes including ATPSCKMT (ATP synthase c subunit lysine N-methyltransferase). FBgn0038869 Alliance "Predicted to enable histone H4K20 methyltransferase activity. Predicted to be involved in negative regulation of gene expression, epigenetic. Predicted to be part of chromatin. Is expressed in anterior midgut primordium; embryonic/larval midgut; embryonic/larval muscle system; organism; and posterior midgut primordium. Orthologous to human SMYD5 (SMYD family member 5)." FBgn0038889 FlyBase Gene Snapshot Fanconi anemia group M helicase (Fancm) encodes a protein that promotes repair of DNA interstrand crosslinks through the Fanconi anemia pathway and non-crossover repair of DNA double-strand breaks. FBgn0004863 FlyBase Gene Snapshot C15 (C15) encodes a transcription factor that regulates gene expression in the leg distal region. FBgn0038890 Alliance Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of endocytic recycling. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Is expressed in adult head. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). FBgn0038894 Alliance Predicted to be active in extracellular space. FBgn0011766 UniProtKB "Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg. (UniProtKB:Q27368)" FBgn0038892 Alliance Predicted to be involved in cilium assembly. Predicted to be active in motile cilium. Orthologous to human CFAP161 (cilia and flagella associated protein 161). FBgn0002941 FlyBase Gene Snapshot slouch (slou) encodes a homeodomain transcription factor that is involved in the specification of a subset of somatic muscle progenitors and muscle founder cells. FBgn0038897 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including embryonic stomatogastric nervous system; embryonic/larval fat body; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1)." FBgn0051343 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head; embryonic small intestine; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1). FBgn0051233 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. FBgn0051198 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head and embryonic hindgut. FBgn0038901 FlyBase Gene Snapshot Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. FBgn0038902 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human CDK20 (cyclin dependent kinase 20). FBgn0041229 UniProtKB "Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior. (UniProtKB:Q9VD76)" FBgn0051431 Alliance "Predicted to be located in plasma membrane. Is expressed in several structures, including amnioserosa; circulatory system primordium; embryonic/larval hemocyte; embryonic/larval midgut primordium; and gut section. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1)." FBgn0064912 Alliance Is expressed in adult head. FBgn0038912 Alliance "Predicted to enable acid phosphatase activity. Predicted to be located in extracellular exosome and nucleus. Is expressed in adult head; eye; and photoreceptor neurons. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4)." FBgn0053092 FlyBase Gene Snapshot "delta-1-Pyrroline-5-carboxylate dehydrogenase 2 (P5CDh2) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation." FBgn0051465 Alliance Is expressed in spermatozoon. FBgn0038917 Alliance Is expressed in organism. Orthologous to human RCCD1 (RCC1 domain containing 1). FBgn0038918 Alliance Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). FBgn0038919 Alliance Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and male accessory gland. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). FBgn0038916 FlyBase Gene Snapshot dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process. FBgn0038915 Alliance Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be active in Golgi apparatus. FBgn0038914 Alliance Is expressed in adult fat body; adult head; and fat cell. FBgn0038909 Alliance Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. Is expressed in embryonic head sensory system; sense organ; and sensory nervous system primordium. FBgn0015229 FlyBase Gene Snapshot gliolectin (glec) encodes a member of carbohydrate-binding proteins. glec product regulates glia-glia and glia-neuron interactions during neurogenesis and positively regulates Notch pathway during the specification of vein and intervein regions in wing imaginal discs. FBgn0045468 Alliance "Predicted to enable ligand-gated monoatomic ion channel activity and taste receptor activity. Predicted to be involved in several processes, including chemosensory behavior; male courtship behavior; and sensory perception of taste. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in several structures, including adult abdomen; adult labral sense organ; adult subesophageal zone; embryonic/larval gustatory receptor neurons; and labellum." FBgn0045469 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9VD74)" FBgn0045470 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IN23)" FBgn0013759 FlyBase Gene Snapshot "CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity." FBgn0003867 FlyBase Gene Snapshot "torso-like (tsl) encodes a protein present in many organs. In particular it is produced and secreted by two cell clusters in the egg chamber, initially anchored at the vitelline membrane and then translocated to the oocyte plasma membrane where it is required for the activation of the receptor encoded by tor." FBgn0038903 Alliance Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be part of RNA polymerase I complex. Orthologous to human POLR1H (RNA polymerase I subunit H). FBgn0027575 Interactive Fly G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit strong presynaptic inhibition - mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling FBgn0038921 Alliance Is expressed in spermatozoon. Orthologous to human SPMAP2 (sperm microtubule associated protein 2). FBgn0038923 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MRPL35 (mitochondrial ribosomal protein L35). FBgn0019957 FlyBase Gene Snapshot "NADH dehydrogenase (ubiquinone) 42 kDa subunit (ND-42) encodes an ortholog of human NDUFA10, a subunit of complex I of the mitochondrial electron transport chain (NADH:ubiquinone reductase). ND-42 acts genetically as a suppressor of some Pink1 phenotypes." FBgn0038928 FlyBase Gene Snapshot Fas-associated death domain (Fadd) encodes an adaptor protein that functions downstream of the product of imd and upstream of the caspase encoded by Dredd in the immune deficiency pathway. FBgn0040582 Alliance Predicted to be located in extracellular space. FBgn0038927 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Orthologous to human CDC40 (cell division cycle 40)." FBgn0038926 Alliance Predicted to enable toxic substance binding activity. Is expressed in eye and spermatozoon. Orthologous to human TMEM181 (transmembrane protein 181). FBgn0038925 Alliance "Predicted to enable holocytochrome-c synthase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; embryonic/larval muscle system; and gut section. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase)." FBgn0038924 Alliance "Predicted to enable acetylpyruvate hydrolase activity. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Orthologous to human FAHD2A (fumarylacetoacetate hydrolase domain containing 2A) and FAHD2B (fumarylacetoacetate hydrolase domain containing 2B)." FBgn0019960 FlyBase Gene Snapshot "Mitofilin (Mitofilin) encodes a major component of the mitochondrial contact site (MICOS) complex, which is located at the mitochondrial crista junctions. It maintains crista structure and contact sites, and regulates mitochondrial motility. Mitofilin product functions downstream of the kinase encoded by Pink1, to maintain mitochondrial structure and cellular homeostasis." FBgn0038922 FlyBase Gene Snapshot Isocitrate dehydrogenase (NAD+) 3 non-catalytic subunit beta (Idh3b) encodes a non-catalytic subunit of the mitochondrial isocitrate dehydrogenase enzyme of the tricarboxylic acid cycle. FBgn0051164 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis; labral sense organ neurons; and ventral cibarial sense organ neurons. FBgn0051163 Alliance "Involved in sensory perception of smell. Is expressed in several structures, including central brain primordium; dorsal epidermis primordium; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human SASH1 (SAM and SH3 domain containing 1) and SAMD5 (sterile alpha motif domain containing 5)." FBgn0038934 FlyBase Gene Snapshot "GLD2 poly(A) polymerase (Gld2) encodes a conserved poly-A polymerase in the GLD2 family. It is a paralog of the wisp gene. Gld2 is expressed strongly in the testis and at low levels in other tissues including the nervous system. In the male germ line, the product of Gld2 is essential for postmeiotic development of sperm; its depletion causes arrest of spermatogenesis prior to individualization, with abnormal nuclear condensation phenotypes. In the brain it is required for long-term memory." FBgn0038938 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A1 (solute carrier family 22 member 1); SLC22A2 (solute carrier family 22 member 2); and SLC22A3 (solute carrier family 22 member 3). FBgn0038941 Alliance Is expressed in embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval posterior spiracle. FBgn0038946 FlyBase Gene Snapshot retinol dehydrogenase B (rdhB) encodes a retinol dehydrogenase involved in rhodopsin biosynthesis. FBgn0038947 FlyBase Gene Snapshot Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. FBgn0260467 Alliance "Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Located in endomembrane system. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIp. Orthologous to human TMEM199 (transmembrane protein 199)." FBgn0038952 Alliance Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). FBgn0038953 Alliance Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Is expressed in organism. Orthologous to human TARBP1 (TAR (HIV-1) RNA binding protein 1). FBgn0038957 Alliance "Predicted to enable 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity and bisphosphoglycerate mutase activity. Predicted to be involved in canonical glycolysis and gluconeogenesis. Predicted to be active in cytosol. Is expressed in eye. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM1 (phosphoglycerate mutase 1); PGAM2 (phosphoglycerate mutase 2); and PGAM4 (phosphoglycerate mutase family member 4)." FBgn0051165 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051166 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038960 Alliance Predicted to be involved in cilium assembly. Predicted to be active in acrosomal vesicle and motile cilium. Is expressed in spermatozoon. Orthologous to human IQUB (IQ motif and ubiquitin domain containing). FBgn0038965 UniProtKB "Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos. (UniProtKB:Q95RA8)" FBgn0038964 Alliance "Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Is expressed in several structures, including adult head; adult heart; lamina; lamina anlage; and stem cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein)." FBgn0038961 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human TBRG4 (transforming growth factor beta regulator 4)." FBgn0051167 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051162 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0038956 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult heart. FBgn0038951 UniProtKB "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity). (UniProtKB:Q9VD25)" FBgn0038948 UniProtKB Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. (UniProtKB:Q9VD28) FBgn0051423 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in ventral cibarial sense organ neurons. FBgn0051424 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis; labellar taste bristle; scolopidial ligament cell; spermatozoon; and ventral cibarial sense organ neurons. FBgn0038972 Alliance Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol. Is expressed in adult abdomen; adult head; organism; ovary; and testis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). FBgn0038973 Alliance "Involved in defense response to bacterium; negative regulation of ERK1 and ERK2 cascade; and regulation of antimicrobial humoral response. Located in cytosol. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval brain; embryonic/larval fat body; embryonic/larval salivary gland; and gut." FBgn0038975 FlyBase Gene Snapshot "Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function." FBgn0038976 FlyBase Gene Snapshot "Prefoldin 5 (Pfdn5) encodes a member of the alpha subunit of the heterohexameric prefoldin complex, which acts as chaperone protein. It is involved in the inhibition of the formation of ectopic neuroblasts." FBgn0038978 FlyBase Gene Snapshot testis-enriched HMG-box-containing protein 1 (tHMG1) encodes a chromosomal protein involved in spermatogenesis. FBgn0038979 FlyBase Gene Snapshot testis-enriched HMG-box-containing protein 2 (tHMG2) encodes a chromosomal protein involved in spermatogenesis. FBgn0053110 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult fat body and embryonic large intestine. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0028837 FlyBase Gene Snapshot COP9 signalosome subunit 6 (CSN6) encodes the subunit 6 of the COP9 signalosome (CSN). The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. FBgn0038989 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human NIFK (nucleolar protein interacting with the FHA domain of MKI67)." FBgn0051158 FlyBase Gene Snapshot Exchange factor for Arf 6 (Efa6) encodes a Guanine Nucleotide Exchange Factor (GEF) that sustains activation of Arf family GTPases. They are active in dynamic actin rearrangement during cell shapes changes as well as cell patterning within epithelia. FBgn0051159 FlyBase Gene Snapshot mitochondrial ribosome recycling factor 2 (mRRF2) encodes a mitochondrial elongation factor that catalyzes the translocation of the mRNAs and tRNAs along the ribosomes via GTP hydrolysis. FBgn0051161 Alliance Is expressed in spermatozoon. FBgn0020278 FlyBase Gene Snapshot locomotion defects (loco) encodes a regulator of G-protein signalling protein. loco product functions in neuroblast asymmetric division and blood-brain barrier formation together with G protein-coupled receptors and inhibitory G-proteins (encoded by Galphai and Galphao). It is also known that decrease of loco expression extends lifespan with stronger resistance to stressors. FBgn0051156 Alliance Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Is expressed in spermatozoon. Orthologous to human SRBD1 (S1 RNA binding domain 1). FBgn0014949 FlyBase Gene Snapshot buttonless (btn) encodes a protein that contributes to cuticle pigmentation. FBgn0053107 Alliance Is expressed in organism. FBgn0024558 Alliance "Predicted to enable diphthine methyl ester synthase activity. Involved in positive regulation of translation. Predicted to be located in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; embryonic anal pad; embryonic/larval midgut primordium; germline cell; and gut section. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Orthologous to human DPH5 (diphthamide biosynthesis 5)." FBgn0038986 Alliance Predicted to enable fatty acid elongase activity. Involved in cholesterol homeostasis; pupal development; and steroid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in embryonic large intestine; embryonic proventriculus; embryonic salivary gland duct; and larval foregut atrium. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0038984 FlyBase Gene Snapshot Adiponectin receptor (AdipoR) encodes a membrane protein that regulates glucose and lipid metabolism by controlling insulin signaling. It also maintains germ line stem cells via an insulin-independent mechanism. FBgn0038983 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0053099 Alliance "Is expressed in several structures, including amnioserosa; anterior endoderm; anterior endoderm anlage; anterior midgut primordium; and mesoderm." FBgn0038981 Alliance "Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; central brain anlage; and mesoderm." FBgn0003676 UniProtKB "Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (UniProtKB:P12613)" FBgn0038977 Alliance Is expressed in spermatozoon. FBgn0038974 Alliance Enables serine hydrolase activity. Is expressed in adult head; adult heart; and organism. Orthologous to human BPHL (biphenyl hydrolase like). FBgn0028688 UniProtKB Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (UniProtKB:Q9V3G7) FBgn0038968 Alliance "Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Orthologous to human URB1 (URB1 ribosome biogenesis homolog)." FBgn0038967 Alliance Is expressed in dorsal head epidermis; embryonic anal pad; embryonic head epidermis; embryonic proventriculus; and embryonic proventriculus inner layer. FBgn0038966 UniProtKB "Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis. (UniProtKB:Q9VD09)" FBgn0039002 Alliance Orthologous to human SAMD5 (sterile alpha motif domain containing 5). FBgn0039004 UniProtKB Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance (PubMed:20547758). (UniProtKB:Q9VCW3) FBgn0039006 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VCW1) FBgn0039008 Alliance Involved in muscle system process. Is expressed in adult head; embryonic/larval muscle system; embryonic/larval somatic muscle cell; somatic muscle primordium; and visceral muscle primordium. FBgn0039017 Alliance Predicted to enable DNA translocase activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to be active in nucleus. Is expressed in organism. FBgn0039019 FlyBase Gene Snapshot Heterochromatin Protein 1c (HP1c) encodes a chromatin binding protein that is involved in telomere capping and transcription regulation and interacts with the zinc-finger proteins encoded by woc and row. FBgn0039025 FlyBase Gene Snapshot Ubiquitin-specific protease 12/46 (Usp12-46) encodes a deubiquitinating enzyme that negatively regulates the Notch signaling pathway. FBgn0039026 Alliance Enables protein phosphatase 1 binding activity. Predicted to be active in cytosol. FBgn0039029 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. FBgn0040588 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. FBgn0039024 Alliance "Involved in compound eye morphogenesis. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic ventral epidermis; epidermis; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1)." FBgn0039023 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039022 Alliance Predicted to be involved in proteolysis. Located in extracellular region. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0051139 Alliance Predicted to enable EGF-domain serine glucosyltransferase activity and EGF-domain serine xylosyltransferase activity. Predicted to be involved in positive regulation of Notch signaling pathway and protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in Dowling-Degos disease and autosomal recessive limb-girdle muscular dystrophy type 2Z. Orthologous to human POGLUT1 (protein O-glucosyltransferase 1). FBgn0039016 UniProtKB "Endoribonuclease which functions in microRNA- (miRNA) gene silencing and, independently of its ribonuclease III activity, also acts in the short interfering RNA- (siRNA) gene silencing pathway (PubMed:11201747, PubMed:11498593, PubMed:15066283, PubMed:15918769, PubMed:15985611, PubMed:17666393, PubMed:17928574, PubMed:19451544, PubMed:19635780, PubMed:21419681, PubMed:21926993, PubMed:24488111, PubMed:36182693). Cleaves hairpin precursor miRNAs (pre-miRNA) to generate mature miRNAs (miRNAs) that are between twenty-one to twenty-four nucleotides in length and function in RNA silencing and post-transcriptional regulation of gene expression (PubMed:15066283, PubMed:15918769, PubMed:15985611, PubMed:17666393, PubMed:17928574, PubMed:19451544, PubMed:19635780, PubMed:21419681, PubMed:21926993, PubMed:23063653, PubMed:24488111, PubMed:36182693). Also functions in miRNA loading and assembly of the Argonaute 1 (AGO1)-containing RNA-induced silencing complex (miRISC), with the miRNAs serving as a guide to direct the miRISC to complementary RNAs to degrade them or prevent their translation (PubMed:15066283, PubMed:17928574, PubMed:19451544). Independently of its catalytic activity, functions in the siRNA silencing pathway by promoting assembly of the siRNA-directed Argonaute 2 (AGO2)-containing RISC (siRISC) (PubMed:15066283). Required for the proper formation of a stable intermediate (R2) in siRISC assembly, which is formed from the R1 precursor complex (containing Dcr-2, R2D2 and the siRNA) and is used for assembly of the mature (R3) siRISC complex (PubMed:15066283). It is not required for siRNA biogenesis (PubMed:15066283, PubMed:21419681). During embryogenesis, involved in germline fate determination (PubMed:16949822). (UniProtKB:Q9VCU9)" FBgn0039015 FlyBase Gene Snapshot Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays. FBgn0039013 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in organism. Used to study hypomyelinating leukodystrophy 23. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220). FBgn0024958 FlyBase Gene Snapshot "Iron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs)." FBgn0051151 FlyBase Gene Snapshot winged eye (wge) encodes a protein that localizes to the histone locus body and regulates histone expression to ensure genomic stability. wge overexpression produces eye to wing transformation. FBgn0039010 Alliance Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). FBgn0039009 Alliance Orthologous to human CCDC142 (coiled-coil domain containing 142). FBgn0039007 FlyBase Gene Snapshot Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. FBgn0039003 FlyBase Gene Snapshot wolfram syndrome 1 (wfs1) encodes an endoplasmic reticulum-resident transmembrane protein. Neuronal knockdown of wfs1 increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration. FBgn0046114 FlyBase Gene Snapshot "Glutamate-cysteine ligase modifier subunit (Gclm) encodes a protein that regulates the ligase activity of the product of Gclc. It is involved in glutathione biosynthesis, arsenic detoxification and response to ethanol." FBgn0017590 FlyBase Gene Snapshot klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. FBgn0039030 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0051281 FlyBase Gene Snapshot Transition protein-like 94D (Tpl94D) encodes a HMG-box domain protein that is expressed during chromatin reorganization in spermatids. FBgn0039031 Alliance Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Is expressed in adult fat body; adult head; and embryonic/larval fat body. FBgn0039033 FlyBase Gene Snapshot Odorant receptor 94a (Or94a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0039034 FlyBase Gene Snapshot Odorant receptor 94b (Or94b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0039038 Alliance Predicted to enable protein-membrane adaptor activity. Predicted to be involved in protein localization to plasma membrane. Predicted to be active in apical plasma membrane. FBgn0039042 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0041225 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IMZ5)" FBgn0027526 FlyBase Gene Snapshot Ubiquitin-like domain-containing C-terminal domain phosphatase 1 (Ublcp1) encodes a nuclear HAD family phospho-Ser/Thr phosphatase that binds and dephosphorylates the nuclear 26S proteasome and inhibits proteasome activity. FBgn0039049 Alliance Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in adult head; embryonic Malpighian tubule; embryonic/larval crystal cell; embryonic/larval garland cell; and organism. Orthologous to human ACY1 (aminoacylase 1). FBgn0039050 Alliance Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in amnioserosa; embryonic/larval crystal cell; embryonic/larval garland cell; and yolk nucleus. Orthologous to human ACY1 (aminoacylase 1). FBgn0039051 Alliance Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in embryonic/larval crystal cell and procrystal cell. Orthologous to human ACY1 (aminoacylase 1). FBgn0039052 Alliance Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Orthologous to human ACY1 (aminoacylase 1). FBgn0039053 Alliance Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in embryonic Malpighian tubule; embryonic/larval crystal cell; and yolk nucleus. Orthologous to human ACY1 (aminoacylase 1). FBgn0039054 FlyBase Gene Snapshot Carrier of Wingless (Cow) encodes a secreted heparan sulfate proteoglycan that binds the product of wg and increases its extracellular mobility. The binding with the ligand encoded by wg is dependent on heparan sulfate modification of the product of Cow. FBgn0039048 Alliance Predicted to be involved in cell morphogenesis. Predicted to be located in membrane. FBgn0053193 FlyBase Gene Snapshot salvador (sav) encodes a scaffold protein involved in the Hippo signalling pathway. It promotes membrane recruitment of the kinase encoded by hpo and its assembly with the product of wts. FBgn0039045 UniProtKB "Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. (UniProtKB:Q9VCR7)" FBgn0039044 FlyBase Gene Snapshot "p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair." FBgn0039043 Alliance "Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in lipid droplet. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section." FBgn0039040 Alliance "Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in lipid droplet. Is expressed in adult fat body and adult head." FBgn0039039 FlyBase Gene Snapshot "lame duck (lmd) encodes a zinc finger transcription factor expressed in the embryonic somatic and visceral mesoderm, where it is essential for the specification of fusion competent myoblasts and for myoblast fusion." FBgn0039056 Alliance "Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be located in membrane. Is expressed in several structures, including Malpighian tubule main body primordium; adult Dh44 neuron of pars intercerebralis; anlage in statu nascendi; gut section; and larval ring gland projection neurons. Orthologous to several human genes including ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1) and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3)." FBgn0039066 FlyBase Gene Snapshot Elongin A (EloA) encodes a transcription elongation factor that enhances the catalytic rate of RNA Polymerase II by suppressing its transient pausing. It associates with the products of EloB and EloC. FBgn0039068 Alliance "Predicted to be involved in peroxisome fission. Located in peroxisome. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; and gut section. Orthologous to human PEX11G (peroxisomal biogenesis factor 11 gamma)." FBgn0025781 FlyBase Gene Snapshot "Cell division cycle 16 (Cdc16) encodes an essential subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding." FBgn0039069 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic Malpighian tubule. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). FBgn0039071 FlyBase Gene Snapshot big bubble 8 (bb8) encodes a glutamate dehydrogenase involved in the development of the spermatid mitochondria. FBgn0039070 FlyBase Gene Snapshot "wampa (wam) encodes a component of the outer dynein arm docking complex that is required for attaching outer dynein arms to the axoneme of the sperm flagellum. It is involved in axonemal assembly, nuclear shaping, and mitochondrial remodeling during spermatogenesis." FBgn0039067 FlyBase Gene Snapshot "will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5." FBgn0039065 UniProtKB Required for repair of DNA double strand breaks which occur during replication or are induced by ionizing radiation (IR) (PubMed:26502056). Functions with dgrn and downstream of the SMC5-SMC6 complex to regulate strand break repair (PubMed:26502056). Likely functions by stabilizing the association of heterochromatic double strand breaks (DSBs) with the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056). (UniProtKB:Q9VCP1) FBgn0039064 Alliance Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cervix carcinoma and type 2 diabetes mellitus. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1); ERAP2 (endoplasmic reticulum aminopeptidase 2); and LNPEP (leucyl and cystinyl aminopeptidase). FBgn0011596 FlyBase Gene Snapshot fuzzy onions (fzo) encodes an evolutionarily conserved transmembrane Dynamin-type GTPase and founder member of the mitofusin class of proteins. It is required for proper fusion of mitochondria during spermatid differentiation to form the Nebenkern mitochondrial formation. FBgn0039059 Alliance Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be active in endoplasmic reticulum membrane. FBgn0039058 UniProtKB "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). (UniProtKB:Q9VCQ3)" FBgn0004395 FlyBase Gene Snapshot "unkempt (unk) encodes a highly conserved protein with roles in mRNA binding and ubiquitination. Together with the product of heca, it acts downstream of the product of mTor to regulate photoreceptor differentiation during eye development." FBgn0051457 Alliance Enables protein phosphatase 1 binding activity. Predicted to be located in nucleus. Is expressed in organism. FBgn0051365 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm." FBgn0039055 FlyBase Gene Snapshot Ras association family member (Rassf) encodes a RASSF (ras-association domain family) protein that binds to the kinase encoded by hpo and promotes its dephosphorylation by the STRIPAK PP2A complex. FBgn0024509 UniProtKB "Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II (PubMed:20144761). Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development (PubMed:20144761). Required for reactivation of transcription after heat shock (PubMed:20144761). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). A component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:27166823). (UniProtKB:Q9V3J4)" FBgn0002622 FlyBase Gene Snapshot "Ribosomal protein S3 (RpS3) encodes a component of the small subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpS3 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. The product of RpS3 also contains a DNA lyase activity and functions in DNA repair." FBgn0051225 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in chemosensory neuron of adult labral sensillum 7; gustatory receptor neuron of the epiphysis; and labral sense organ neurons. FBgn0039079 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis and larval hypopharyngeal organ gustatory receptor neurons. FBgn0039080 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neurons; labral sense organ neurons; prothoracic tarsal segment 5; and terminal organ. FBgn0039087 Alliance Predicted to enable UDP-glycosyltransferase activity. Orthologous to human UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). FBgn0039086 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0039085 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in embryonic small intestine and embryonic/larval midgut. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0039083 Alliance Predicted to enable protein serine/threonine kinase activity. Involved in Golgi organization and negative regulation of cell size. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and depressive disorder. Orthologous to human STK33 (serine/threonine kinase 33). FBgn0039081 FlyBase Gene Snapshot "Inwardly rectifying potassium channel 2 (Irk2) encodes a protein that is required in transepithelial fluid secretion and potassium transport in the Malpighian tubule. It contributes to wing patterning, through the regulation of release of the product of dpp." FBgn0039078 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus." FBgn0039077 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. FBgn0051515 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; leukemia (multiple); osteonecrosis; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human TFPI (tissue factor pathway inhibitor) and TFPI2 (tissue factor pathway inhibitor 2)." FBgn0039075 Alliance Predicted to be active in cytosol. Is expressed in spermatozoon. Orthologous to several human genes including ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). FBgn0039073 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and organism. Orthologous to human CPA5 (carboxypeptidase A5). FBgn0016119 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. (UniProtKB:Q24407)" FBgn0039089 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Is expressed in adult head. FBgn0039098 UniProtKB Involved in the immune response to bacterial infection. (UniProtKB:Q9VCK2) FBgn0039099 FlyBase Gene Snapshot Gamma-interferon-inducible lysosomal thiol reductase 2 (GILT2) encodes a unique thiol reductase that catalyzes the disulfide bond reduction. It is involved in immune response against bacterial and viral challenge via JAK-STAT signaling pathway. FBgn0039101 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0042106 Alliance "Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; posterior endoderm; somatic muscle primordium; and trunk mesoderm." FBgn0039102 FlyBase Gene Snapshot "Spatzle-Processing Enzyme (SPE) encodes a secreted serine protease that participates in the cleavage of the Toll ligand encoded by spz during the immune response, leading to Toll pathway activation in the fat body and haemocytes." FBgn0051148 Alliance "Enables glucosylceramidase activity. Involved in several processes, including adult locomotory behavior; cellular response to unfolded protein; and determination of adult lifespan. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1)." FBgn0051413 Alliance Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Predicted to be active in Golgi membrane and extracellular space. Is expressed in adult head. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). FBgn0051414 FlyBase Gene Snapshot Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose. FBgn0039106 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0039107 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in cytosol and late endosome. Is expressed in embryonic/larval midgut; embryonic/larval midgut interstitial cell; midgut interstitial cell primordium; and posterior midgut primordium. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0039109 Alliance "Predicted to enable Notch binding activity and glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process and neurogenesis. Predicted to be located in trans-Golgi network. Predicted to be active in cytoplasm. Is expressed in several structures, including amnioserosa; anterior endoderm; anterior endoderm anlage; embryonic/larval salivary gland; and posterior ectoderm anlage. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)." FBgn0028684 FlyBase Gene Snapshot "Regulatory particle triple-A ATPase 5 (Rpt5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus." FBgn0039111 FlyBase Gene Snapshot "Protein tyrosine phosphatase, mitochondrial 1 (PTPMT1) encodes a key player in the biosynthesis of cardiolipin in the mitochondria." FBgn0039112 UniProtKB Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (UniProtKB:Q9VCI5) FBgn0028475 Alliance Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). FBgn0039110 FlyBase Gene Snapshot Ran binding protein 3 (RanBP3) encodes a chromosome region maintenance 1 (CRM1) cofactor involved in the export of proteins from the nucleus. It negatively regulates Wnt signalling. FBgn0028691 Alliance "Predicted to enable structural molecule activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Orthologous to human PSMD13 (proteasome 26S subunit, non-ATPase 13)." FBgn0039108 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0002922 FlyBase Gene Snapshot nautilus (nau) encodes a protein that belongs to the bHLH family of transcription factors. It is the unique Drosophila ortholog of the mammalian family of bHLH Myogenic Regulatory Factors. It is involved in somatic muscle myogenesis. FBgn0043005 FlyBase Gene Snapshot "portabella (prt) encodes an orphan vesicular transporter expressed in a discrete number of cells in larvae and adults, including Kenyon cells of the mushroom bodies. prt depletion produces male mating behavior defects and a modest learning deficit." FBgn0039104 Alliance Predicted to be active in cytoskeleton. Is expressed in adult head; spermatozoon; and testis. Orthologous to several human genes including CIMAP1A (ciliary microtubule associated protein 1A). FBgn0027512 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein monoubiquitination. Predicted to be located in cytoplasm. Is expressed in adult head and organism. Orthologous to human UBE2O (ubiquitin conjugating enzyme E2 O). FBgn0051145 UniProtKB Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. (UniProtKB:A4VCL2) FBgn0039094 Alliance Predicted to enable L-allo-threonine aldolase activity. Predicted to be involved in glycine biosynthetic process and threonine catabolic process. Predicted to be active in cytosol. Is expressed in adult head. FBgn0051143 Alliance Predicted to enable UUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0039093 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0039092 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0053337 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0039091 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0004187 Alliance "Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP." FBgn0004186 Alliance "Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP." FBgn0051141 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in testis. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0039125 UniProtKB "Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. (UniProtKB:Q9VCG4)" FBgn0047114 Alliance Is expressed in organism. FBgn0039128 Alliance Predicted to be involved in regulation of exit from mitosis. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human MAD2L1BP (MAD2L1 binding protein). FBgn0039130 Alliance "Is expressed in several structures, including adult head; anterior endoderm anlage; mesoderm; midline primordium; and plasmatocyte primordium." FBgn0039132 Alliance "Enables clathrin adaptor activity. Involved in axon guidance; compound eye photoreceptor development; and intracellular transport. Part of AP-1 adaptor complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Orthologous to several human genes including AP1S2 (adaptor related protein complex 1 subunit sigma 2)." FBgn0051140 Alliance "Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and protein kinase C signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human DGKQ (diacylglycerol kinase theta)." FBgn0051451 FlyBase Gene Snapshot "mimi (lncRNA:mimi) is a long-noncoding RNA expressed exclusively in the nervous system. Its expression levels are undetectable to very low during embryonic and larval stages, and very high in the adult brain. lncRNA:mimi is necessary for the formation of large neuronal granules marked by the protein stau, and its deletion in null mutants causes granule disassembly. Adult lncRNA:mimi mutant flies suffer from a shortened life span, age-dependent progressive motor decline, and display a loss of transcriptome signatures of neuronal maturity." FBgn0039136 Alliance "Is expressed in organism. Human ortholog(s) of this gene implicated in midface hypoplasia, hearing impairment, elliptocytosis, and nephrocalcinosis. Orthologous to human AMMECR1 (AMMECR nuclear protein 1) and AMMECR1L (AMMECR1 like)." FBgn0015795 FlyBase Gene Snapshot Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. FBgn0053108 UniProtKB "Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation. (UniProtKB:Q9VCE8)" FBgn0051184 Alliance "Predicted to enable RNA binding activity. Involved in P-body assembly. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in head mesoderm; organism; and trunk mesoderm. Orthologous to human LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)." FBgn0020647 Alliance "Predicted to be involved in protein localization to plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome and developmental and epileptic encephalopathy 66. Orthologous to several human genes including PACS2 (phosphofurin acidic cluster sorting protein 2)." FBgn0039137 UniProtKB "Steroid phosphatase that dephosphorylates ecdysteroids such as ecdysone 22-phosphate (E22P), 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P) (PubMed:17348005). Likely catalyzes the conversion of inactive phosphorylated ecdysteroids into their active forms (By similarity). Shows high activity towards ecdysone 22-phosphate (E22P), but is also significantly active against 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P) (PubMed:17348005). Also displays acid phosphatase activity towards 4-nitrophenyl phosphate (pNNP) in vitro (PubMed:17348005). Has no activity towards 3-epi-ecdysone 3-phosphate (E3P) (PubMed:17348005). (UniProtKB:Q9VCE9)" FBgn0039135 Alliance Is expressed in adult head. Orthologous to human TMEM179 (transmembrane protein 179). FBgn0005674 UniProtKB "Catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro). (UniProtKB:P28668)" FBgn0039131 Alliance "Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; embryonic Malpighian tubule tip cell; embryonic hypopharynx; epithelium; and gut section." FBgn0039129 Alliance Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in adult head. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). FBgn0015282 FlyBase Gene Snapshot "Regulatory particle triple-A ATPase 2 (Rpt2) encodes one of six ATPases that form the base of the regulatory 19S cap of the proteasome. The Rpt2 product is involved in the recognition of specific substrates destined for degradation, such as those involved in Notch signalling pathway." FBgn0039126 Alliance Predicted to be involved in regulation of lipid metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). FBgn0016754 UniProtKB "Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1) (PubMed:36180891). Important for maintaining stability of the PR-DUB complex (PubMed:36180891). Probable epigenetic regulator involved in developmental pattern formation and eye development (PubMed:22726846, PubMed:9372180). (UniProtKB:A8JR92)" FBgn0039124 FlyBase Gene Snapshot "testis-specifically expressed bromodomain containing protein-1 (tbrd-1) encodes a protein involved in gene activation that is required for male germ cell differentiation. It interacts with the products of tbrd-2, tbrd-3 and testis-specific TAFs." FBgn0013347 FlyBase Gene Snapshot "Transcription-factor-IIA-S (TfIIA-S) encodes one of the basal transcription factors required for the formation of the pre-initiation complex (PIC) at Pol II-transcribed genes. It stabilizes the product of Tbp-TATA box interaction, thus promoting PIC formation." FBgn0025574 FlyBase Gene Snapshot Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway. FBgn0004185 Alliance "Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP." FBgn0039139 FlyBase Gene Snapshot "Methyltransferase like 3 (Mettl3) encodes an RNA N6-methyladenosine transferase that contributes to oogenesis, lifespan and behaviour, including flight, locomotion and grooming." FBgn0039141 FlyBase Gene Snapshot "spastin (spas) encodes a member of the AAA ATPase family that assembles into hexamers and severs microtubules along their lengths. The microtubule binding and severing activities of the product of spas are dependent upon tubulin glutamylation levels. Its proposed roles include mitosis, axon transport, synapse formation, dendrite arborization, organelle tubulation, and lipid droplet metabolism." FBgn0043455 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2-type prespliceosome. Is expressed in organism; wing hinge primordium; and wing pouch. Orthologous to human SDE2 (SDE2 telomere maintenance homolog)." FBgn0026576 Alliance Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Used to study retinal disease. Orthologous to human PISD (phosphatidylserine decarboxylase). FBgn0039145 Alliance Is expressed in adult heart and organism. Orthologous to human TSTD1 (thiosulfate sulfurtransferase like domain containing 1). FBgn0040283 FlyBase Gene Snapshot Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA1 to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. FBgn0039147 Alliance "Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol and nucleoplasm. Orthologous to human RAD23B (RAD23 homolog B, nucleotide excision repair protein)." FBgn0039149 Alliance Orthologous to human ARL6IP4 (ADP ribosylation factor like GTPase 6 interacting protein 4). FBgn0039152 FlyBase Gene Snapshot "Rootletin (Root) encodes the major structural component of the ciliary rootlet. It is expressed in sensory neurons and is required for ciliary-transmitted sensory functions including hearing, touch and taste." FBgn0026317 FlyBase Gene Snapshot Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. FBgn0039154 Alliance Predicted to enable sterol binding activity. Predicted to be involved in sterol transport. FBgn0039155 Alliance "Predicted to enable peptidase inhibitor activity. Predicted to be involved in neuron differentiation. Located in external side of plasma membrane and extracellular region. Is expressed in several structures, including amnioserosa; border follicle cell; cephalopharyngeal skeleton; embryonic segment; and gut section. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1)." FBgn0039156 Alliance "Enables long-chain fatty acid-CoA ligase activity. Involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Predicted to be located in peroxisome. Is expressed in several structures, including adult head; adult heart; epithelium; ganglia; and gut section." FBgn0039158 Alliance "Enables TSC1-TSC2 complex binding activity. Involved in glucose homeostasis and negative regulation of insulin secretion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human TBC1D7 (TBC1 domain family member 7)." FBgn0026598 FlyBase Gene Snapshot "Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development." FBgn0039161 Alliance Is expressed in dorsal head epidermis; embryonic head epidermis; and larval foregut atrium. FBgn0029503 FlyBase Gene Snapshot "morgana (mora) encodes an evolutionarily conserved co-chaperone of the product of Hsp83 that controls neuronal cell growth in the context of dendrite remodeling. Dendritic growth and branching are controlled by at least partly separate mechanisms. The Insulin/IGF signaling (IIS)/TORC1 pathways control both growth and branching to avert underdevelopment, whereas the products of mora and rictor realize proportional scaling of the entire arbor." FBgn0039165 Alliance Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated heterochromatin formation. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Is expressed in organism. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). FBgn0026257 FlyBase Gene Snapshot caravaggio (cav) is a fast evolving gene that encodes HP1/ORC Associated Protein (HOAP). HOAP is a DNA binding protein strongly enriched at chromosome ends and required for telomere capping. FBgn0039170 Alliance Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex and transcription regulator complex. Orthologous to human PTOV1 (PTOV1 extended AT-hook containing adaptor protein). FBgn0002863 FlyBase Gene Snapshot Accessory gland protein 95EF (Acp95EF) encodes a peptide produced by the male accessory glands and transferred to females during mating. FBgn0043884 UniProtKB "Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway (PubMed:11782402). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:26251439). (UniProtKB:Q9VCA8)" FBgn0039172 UniProtKB "Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). (Microbial infection) Plays an important role in infection by flaviviruses such as West Nile virus and Dengue virus type 2. (UniProtKB:Q9VCA9)" FBgn0039169 FlyBase Gene Snapshot "Sp1-like factor for pairing sensitive-silencing (Spps) encodes a zinc-finger protein in the Sp1/KLF family. It binds to Polycomb response elements, and is required for the recruitment of Polycomb group proteins to some of them." FBgn0011725 FlyBase Gene Snapshot "twin (twin) encodes the CCR4 deadenylase, one of two enzymes in the CCR4-NOT complex that degrade mRNA poly(A) tails. It is required during oogenesis in germline stem cell self-renewal, synchronous germ cell division and prevention of cell death, as well as in early embryonic patterning through the deadenylation of specific maternal mRNAs." FBgn0039167 Alliance "Is expressed in several structures, including anlage in statu nascendi; antennal anlage; epidermis; gut section; and head epidermis primordium." FBgn0039163 Alliance Predicted to be involved in cytoplasmic translation. Orthologous to human RWDD1 (RWD domain containing 1). FBgn0039160 Alliance "Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2 (lectin, mannose binding 2) and LMAN2L (lectin, mannose binding 2 like)." FBgn0039159 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head. Orthologous to human MRPS24 (mitochondrial ribosomal protein S24). FBgn0015765 FlyBase Gene Snapshot "p38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression." FBgn0051133 FlyBase Gene Snapshot Seryl-tRNA synthetase-like insect mitochondrial protein (Slimp) encodes an essential mitochondrial protein with a sharp expression profile during the G2 phase of the cell cycle. FBgn0039153 UniProtKB Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (UniProtKB:Q9VCD0) FBgn0039151 Alliance "Is expressed in several structures, including embryonic epipharynx; embryonic hypopharynx; gut section; mesoderm; and mesoderm anlage." FBgn0039150 Alliance "Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in positive regulation of ERAD pathway. Is expressed in adult head and organism. Orthologous to several human genes including RNFT2 (ring finger protein, transmembrane 2)." FBgn0053100 FlyBase Gene Snapshot "eukaryotic translation initiation factor 4E homologous protein (eIF4EHP) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA and functions as a negative regulator of translation. The product of eIF4EHP contributes to embryonic patterning by negatively regulating translation of the products of cad and hb, and is also implicated in regulating ecdysone biosynthesis." FBgn0013343 UniProtKB "Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:7834751). Essential for embryonic viability and development (PubMed:7834751). Required for coordinated peristaltic contractions (PubMed:7834751). Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens in tracheal fusion cells (Fcs) by interacting with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells (PubMed:27323327). (UniProtKB:Q24547)" FBgn0001230 FlyBase Gene Snapshot Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. FBgn0005649 FlyBase Gene Snapshot Rox8 (Rox8) encodes a protein involved in the regulation of alternative mRNA splicing. FBgn0039140 FlyBase Gene Snapshot Mitochondrial Rho (Miro) encodes an atypical GTPase and Ca[2+] sensor on the outer mitochondrial membrane that is vital for mitochondrial homeostasis and microtubule-based mitochondrial transport. It mediates linkage to kinesin and dynein motors through interactions with Milton/TRAK adaptor proteins. FBgn0051130 Alliance Predicted to enable UUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0019952 UniProtKB Probably transports organic cations. (UniProtKB:Q9VCA2) FBgn0039178 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Orthologous to human SLC22A6 (solute carrier family 22 member 6). FBgn0011785 FlyBase Gene Snapshot "BRWD3 (BRWD3) encodes a member of the Bromodomain and WD repeat_containing protein (BRWD) family. It regulates ecdysone and JAK-STAT signaling pathways and contributes to eye development, cell death and phagocytosis." FBgn0039183 FlyBase Gene Snapshot "Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance." FBgn0039184 Alliance Predicted to enable propionate-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix. Is expressed in adult fat body and adult head. Orthologous to human ACSS3 (acyl-CoA synthetase short chain family member 3). FBgn0011581 UniProtKB Myoinhibiting neuropeptide. (UniProtKB:P61849) FBgn0039187 Alliance "Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including intracellular protein transmembrane transport; positive regulation of protein targeting to membrane; and positive regulation of transport. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5)." FBgn0053340 Alliance Is expressed in adult head and spermatozoon. FBgn0039200 Alliance Is expressed in embryonic anal pad and embryonic large intestine. FBgn0000036 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor alpha1 (nAChRalpha1) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel." FBgn0039197 Alliance "Is expressed in several structures, including dorsal head epidermis primordium; embryonic anal pad; embryonic/larval midgut primordium; epithelium; and gut section." FBgn0039196 Alliance "Is expressed in several structures, including dorsal head epidermis primordium; embryonic anal pad; embryonic/larval midgut primordium; epithelium; and gut section." FBgn0039195 Alliance Is expressed in embryonic anal pad. FBgn0039190 Alliance Is expressed in embryonic anal pad. FBgn0039189 Alliance "Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be active in mitochondrion. Is expressed in adult head; gonad; and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial)." FBgn0039188 UniProtKB May be involved in maintaining Golgi structure and in intra-Golgi transport. (UniProtKB:Q8SZ63) FBgn0039186 Alliance Is expressed in adult head and larval midline neurons. FBgn0039182 UniProtKB Involved in rRNA processing or maturation during ribosome biogenesis. (UniProtKB:Q9VC94) FBgn0028471 FlyBase Gene Snapshot Nuclear polyadenosine RNA-binding 2 (Nab2) encodes a zinc-finger polyadenosine RNA binding protein that is expressed widely in many cell types but required specifically within the developing nervous system for proper behavior and axonogenesis. The product of Nab2 in supports in neurons short term memory and development of the brain mushroom bodies. FBgn0039180 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in organism. FBgn0039175 FlyBase Gene Snapshot "Phenylalanyl-tRNA synthetase, beta-subunit (beta-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the alpha-subunit it forms a tetrameric enzyme complex. This subunit plays a role in recognition and binding of tRNAPhe and it provides the editing site that hydrolyzes wrongfully activated or ligated compounds." FBgn0000039 UniProtKB "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (UniProtKB:P17644)" FBgn0039201 UniProtKB "Component of the DZIP1-Fam92-Cby complex which promotes ciliogenesis in sensory neurons and spermatocytes by acting downstream of Cep290 to initiate early ciliary membrane formation and thus transition zone (TZ) assembly (PubMed:31821146, PubMed:33370260). During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules (PubMed:31821146). Within the complex, required to recruit or stabilize Rab8, Fam92 and Cby at the distal basal body of cilia to promote early ciliary membrane formation and initiate TZ assembly (PubMed:31821146). Also acts with Fam92 to restrict Cep290 localization to the proximal part of the TZ (PubMed:31821146). May also be involved in recruitment or stabilization of Mks1 at the TZ (PubMed:31821146). (UniProtKB:Q9VC70)" FBgn0003134 FlyBase Gene Snapshot Protein phosphatase 1alpha at 96A (Pp1alpha-96A) encodes a phosphatase involved in the regulation of Hedgehog and Wnt signaling pathways. FBgn0039203 Alliance Predicted to be active in extracellular space. Is expressed in adult head; embryonic anal pad; and larval foregut atrium. FBgn0039204 Alliance Enables small GTPase binding activity. Predicted to be involved in Rab protein signal transduction. Located in early endosome. Is expressed in embryonic/larval garland cell; organism; and spermatozoon. Orthologous to human PPP1R21 (protein phosphatase 1 regulatory subunit 21). FBgn0011845 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0004188 Alliance "Predicted to enable U4 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U6 snRNP." FBgn0004189 Alliance "Predicted to enable U4 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U6 snRNP." FBgn0004190 Alliance "Predicted to enable U4 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U6 snRNP." FBgn0039213 FlyBase Gene Snapshot atlastin (atl) encodes a dynamin-like membrane-bound GTPase that mediates endoplasmic reticulum membrane fusion in a GTP-dependent fashion. It is required for normal growth of muscles and synapses at the neuromuscular junction. FBgn0000139 FlyBase Gene Snapshot "absent, small, or homeotic discs 2 (ash2) encodes a component of the histone methyltransferase complex that specifically methylates lysine 4 of histone H3 and a member of the trithorax family. ash2 mutants show homeotic transformations and a variety of pattern-formation defects." FBgn0051126 Alliance Predicted to be active in mitochondrion. Is expressed in adult heart. Orthologous to human BOLA1 (bolA family member 1). FBgn0020018 Alliance Predicted to enable oxygen-dependent protoporphyrinogen oxidase activity. Predicted to be involved in heme biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; adult heart; and organism. Used to study porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). FBgn0051125 Alliance Is expressed in organism. FBgn0039214 FlyBase Gene Snapshot "puffyeye (puf) encodes an essential deubiquitinating enzyme that acts as a ubiquitin-specific protease. It removes ubiquitin polypeptide chains from the products of Myc and CycE, thereby stabilizing these proteins and increasing their abundance to influence cell growth and proliferation. The product of puf binds to the product of ago as well as its substrates. It antagonizes ago function." FBgn0046685 UniProtKB Probably lacks tyrosine-protein kinase activity. (UniProtKB:P83097) FBgn0039212 FlyBase Gene Snapshot Syntaxin 18 (Syx18) encodes a SNAP receptor involved in neuromuscular synaptic transmission. FBgn0039210 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome. Is expressed in organism. Orthologous to human BUD13 (BUD13 homolog)." FBgn0039209 FlyBase Gene Snapshot "Repressed by TOR (REPTOR) encodes a transcription factor that shuttles between cytoplasm and nucleus depending on the state of the activity of the product of mTor. Together with its binding partner encoded by REPTOR-BP, it mediates much of the transcriptional response observed upon Tor complex 1 inhibition." FBgn0039205 Alliance "Predicted to enable 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2)." FBgn0004118 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides." FBgn0039217 Alliance Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of DNA methylation-dependent heterochromatin formation and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in embryonic hypopharynx; embryonic/larval tracheal dorsal trunk; embryonic/larval visceral tracheal branch; and ventral sensory complex primordium. FBgn0039218 UniProtKB "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, Polr2L is part of the core element with the central large cleft (By similarity). (UniProtKB:Q9VC49)" FBgn0004885 FlyBase Gene Snapshot "tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands." FBgn0003719 FlyBase Gene Snapshot "tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa." FBgn0000140 UniProtKB Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation. (UniProtKB:Q9VC45) FBgn0040600 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0039225 UniProtKB "Required in dopaminergic neurons to regulate expression of genes involved in dopamine signaling. Decreases expression of the dopamine transporter DAT and increases expression of the dopamine transporter Vmat and the tyrosine 3-monooxygenase ple which is involved in dopamine biosynthesis. Also involved in negatively regulating the expression of a group of endoplasmic reticulum proteins, the molecular chaperone Calr and the protein disulfide isomerases CaBP1 and ERp60. (UniProtKB:Q8MRW5)" FBgn0039228 Alliance Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Is expressed in dorsal sensory complex proper primordium; embryonic head sensory system; sensory nervous system primordium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in drug dependence; heroin dependence; nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). FBgn0039232 FlyBase Gene Snapshot "sosie (sosie) encodes a protein that localizes to the plasma membrane in the germ line and the follicle cells during oogenesis. It interacts with the products of kst, jbug and chic, and helps localizing the product of kst and Actins." FBgn0013953 FlyBase Gene Snapshot Epidermal stripes and patches (Esp) encodes a protein involved in female remating receptivity. FBgn0039233 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; salivary gland body primordium; and trunk mesoderm. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7)." FBgn0039234 FlyBase Gene Snapshot "Nicastrin (Nct) encodes a transmembrane protein that is a key component of the gamma-secretase, the protease complex for proteolytic cleavage of the Notch signaling receptor." FBgn0039238 Alliance Is expressed in embryonic anal pad; embryonic large intestine; hindgut proper primordium; and large intestine primordium. FBgn0013949 Alliance Involved in response to nicotine. Is expressed in embryonic/larval fat body. FBgn0039241 Alliance "Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in wound healing. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)." FBgn0043799 Alliance "Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; clypeo-labral primordium; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1)." FBgn0039244 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; epithelium; and gut section. Human ortholog(s) of this gene implicated in arteriosclerosis and sitosterolemia. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5)." FBgn0039246 Alliance Predicted to enable microtubule binding activity. Predicted to be part of kinesin complex. FBgn0051382 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0039249 Alliance Predicted to be active in cytosol. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). FBgn0039250 Alliance "Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Located in mitotic spindle and nucleus. Is expressed in several structures, including CNS glial cell; antennal primordium; central brain primordium; ganglia; and head epidermis primordium." FBgn0039251 Alliance Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing; nuclear polyadenylation-dependent ncRNA catabolic process; and polyadenylation-dependent ncRNA catabolic process. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in organism and spermatozoon. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). FBgn0051416 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0040601 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic antennal sense organ; embryonic head sensory system; and labral sensory complex. FBgn0051121 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Malpighian tubule main body primordium; adult head; clypeo-labral primordium; dorsal ectoderm; and gut section. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8)." FBgn0039240 Alliance Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP8 (dipeptidyl peptidase 8) and DPP9 (dipeptidyl peptidase 9). FBgn0015625 FlyBase Gene Snapshot "Cyclin B3 (CycB3) encodes a protein that binds to the product of Cdk1, presumably promoting Cdk1's protein kinase activity. The complex CycB3-Cdk1 cooperates with other Cdk1 complexes (CycA-Cdk1 and CycB-Cdk1) to promote the G2/M transition. Like the products of CycA and CycB, the product of CycB3 is also rapidly degraded during exit from mitosis and during G1. It appears to have a specific role in activating the APC/C-dependent degradation pathway." FBgn0039239 Alliance Involved in defense response to virus. FBgn0039237 Alliance Is expressed in embryonic/larval posterior spiracle. FBgn0051105 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta) and SCNN1G (sodium channel epithelial 1 subunit gamma). FBgn0039235 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Orthologous to human CA6 (carbonic anhydrase 6). FBgn0051119 Alliance Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC11 (histone deacetylase 11). FBgn0051357 Alliance "Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut interstitial cell; embryonic/larval midgut primordium; and ganglia. Orthologous to human MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase)." FBgn0051118 Alliance "Predicted to enable GTPase activity. Predicted to be involved in Rab protein signal transduction; exocytosis; and protein secretion. Located in neuronal cell body and synapse. Is expressed in several structures, including Bolwig organ; brain; imaginal disc; mushroom body; and synaptic neuropil domain." FBgn0045980 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be located in cilium. Predicted to be active in nucleus. Used to study amyotrophic lateral sclerosis type 24. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome; nephronophthisis 9; and renal-hepatic-pancreatic dysplasia. Orthologous to several human genes including NEK9 (NIMA related kinase 9). FBgn0027617 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in head mesoderm; organism; and trunk mesoderm. Orthologous to human PPIL4 (peptidylprolyl isomerase like 4)." FBgn0027539 FlyBase Gene Snapshot lilipod (lili) encodes a multi-pass transmembrane protein required for Dpp signal transduction in the female germline to promote ovarian stem cell maintenance. FBgn0039227 FlyBase Gene Snapshot "polybromo (polybromo) encodes a subunit of Polybromo-associated Brahma complex (PBAP). Its main biological role is involved in chromatin remodeling together with Brahma complex. It can also regulate gene transcription through DNA binding, which is dependent or independent ofthe PBAP complex." FBgn0039226 FlyBase Gene Snapshot Uracil-DNA degrading factor (Ude) encodes a DNA-processing enzyme with uracil-DNA-degrading activity. FBgn0039223 Alliance Predicted to enable branched-chain amino acid transmembrane transporter activity. Predicted to be involved in branched-chain amino acid transport. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human SLC25A44 (solute carrier family 25 member 44). FBgn0015591 UniProtKB May act as a neurotransmitter or neuromodulator. (UniProtKB:Q9VC44) FBgn0039219 Alliance Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human METAP1 (methionyl aminopeptidase 1). FBgn0039252 Alliance "Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval hypodermal muscle cell; embryonic/larval midgut primordium; and gut section." FBgn0039254 FlyBase Gene Snapshot "Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration." FBgn0039257 Interactive Fly extracellular matrix - neuromuscular junction - synaptic cleft - presynapse - postsynapse - integrin ligand - wing morphogenesis - male genital looping - diameter expansion of the hindgut tube FBgn0039258 FlyBase Gene Snapshot beta-4-galactosyltransferase 7 (beta4GalT7) encodes an enzyme that transfers a Gal to the Xyl-O-Ser in the tetrasaccharide structure of the protein-linkage region of glycosaminoglycans (GAGs). It is involved in Hh and Dpp signaling pathways mediated by GAGs in development. FBgn0015240 FlyBase Gene Snapshot Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis. FBgn0051115 UniProtKB Purine nucleoside phosphorylase involved in purine salvage. (UniProtKB:Q8IMU4) FBgn0045866 UniProtKB "Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected. (UniProtKB:Q8SXY6)" FBgn0039264 Alliance Is expressed in embryonic/larval tracheal dorsal trunk. FBgn0039265 Alliance "Located in endomembrane system. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; gland; and gut section." FBgn0039266 Alliance "Is expressed in several structures, including amnioserosa; antennal anlage; antennal primordium; head epidermis primordium; and mesoderm." FBgn0039270 FlyBase Gene Snapshot "Poly-glutamine tract binding protein 1 (PQBP1) encodes a component of nuclear speckles and cytoplasmic stress granules. It is involved in RNA transcription, RNA splicing, and possibly in protein translation." FBgn0039271 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in mitotic DNA damage checkpoint signaling; mitotic DNA replication checkpoint signaling; and nuclear DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF830 (zinc finger protein 830). FBgn0039272 Alliance "Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic dorsal epidermis; embryonic head epidermis; embryonic hypopharynx; embryonic ventral epidermis; and gut section." FBgn0039274 Alliance Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. Is expressed in adult brain; adult brain cell body rind; adult head; and adult heart. Orthologous to human IMP4 (IMP U3 small nucleolar ribonucleoprotein 4). FBgn0004897 UniProtKB Involved in development during embryogenesis. (UniProtKB:P32028) FBgn0004898 UniProtKB Involved in development during embryogenesis. (UniProtKB:P32029) FBgn0046214 FlyBase Gene Snapshot "vig2 (vig2) encodes a protein involved in heterochromatin organization, histone H3-K9 methylation and chromatin silencing regulation." FBgn0039282 Alliance "Involved in negative regulation of canonical Wnt signaling pathway. Colocalizes with plasma membrane. Is expressed in several structures, including anlage in statu nascendi; epithelium; ganglia; head epidermis primordium; and imaginal disc. Orthologous to human FRMD8 (FERM domain containing 8) and FRMD8P1 (FERM domain containing 8 pseudogene 1)." FBgn0039283 UniProtKB "Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures. (UniProtKB:Q9VBW9)" FBgn0039280 UniProtKB "Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group. (UniProtKB:Q9VBX2)" FBgn0051510 Alliance Is expressed in adult head. FBgn0039277 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039273 FlyBase Gene Snapshot shams (shams) encodes a xylosyltransferase involved in protein O-linked glycosylation and Notch signalling regulation. FBgn0011336 Alliance "Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ix. Orthologous to human STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B)." FBgn0039269 FlyBase Gene Snapshot veli (veli) encodes a protein involved in border follicle cell migration and regulation of synaptic growth at the neuromuscular junction. FBgn0051111 Alliance Predicted to be located in nucleus. Orthologous to human TBRG1 (transforming growth factor beta regulator 1). FBgn0051109 Alliance Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. Is expressed in nurse cell; oocyte; and organism. FBgn0039261 UniProtKB "Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:28675155, PubMed:33428246). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability (PubMed:28675155, PubMed:33428246). Together with Fmr1, regulates axonal growth in the mushroom bodies and neuromuscular junctions by repressing the translation of several mRNAs, such as those of chic and futsch (PubMed:33428246). (UniProtKB:Q9VBZ5)" FBgn0039260 FlyBase Gene Snapshot "Smg6 (Smg6) encodes an RNA endonuclease that is required for nonsense mediated mRNA decay (NMD). Upon recognition of an NMD-targeted transcript, it cleaves the mRNA in the vicinity of the termination codon, exposing free 5' and 3' ends leading to the complete exonucleolytic degradation of the target." FBgn0039259 Alliance Involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of EMC complex. Is expressed in adult heart and organism. Orthologous to human EMC6 (ER membrane protein complex subunit 6). FBgn0029157 FlyBase Gene Snapshot slingshot (ssh) encodes a protein that plays a pivotal role in actin dynamics by reactivating/dephosphorylating the product of tsr in vivo. FBgn0020626 FlyBase Gene Snapshot Oxysterol binding protein (Osbp) encodes a protein important for sperm development. FBgn0051108 Alliance "Enables tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cilium. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; ganglia; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5)." FBgn0039286 FlyBase Gene Snapshot distal antenna (dan) encodes a pipsqueak-type transcription factor that functions downstream of the gene encoded by Dll. It is required for the expression of a subset of olfactory receptor genes in the antenna. FBgn0039288 Alliance "Is expressed in several structures, including amnioserosa; amnioserosa anlage; amnioserosa primordium; anlage in statu nascendi; and clypeo-labral anlage." FBgn0039290 Alliance Predicted to be located in membrane. Is expressed in adult head. Orthologous to human PGAP6 (post-GPI attachment to proteins 6) and TMEM8B (transmembrane protein 8B). FBgn0051106 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human SVOPL (SVOP like). FBgn0051103 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human SVOPL (SVOP like). FBgn0039293 Alliance "Predicted to enable dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity and dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase)." FBgn0039297 Alliance Predicted to be active in extracellular space. Is expressed in adult fat body. FBgn0039298 UniProtKB "Participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities. Involved in male courtship behavior. In the brain-associated fat body, transcription is enhanced by the dsx and fru male-specific isoforms and repressed by the dsx female-specific isoform. (UniProtKB:Q9VBV3)" FBgn0039299 Alliance Predicted to be active in extracellular space. FBgn0039301 UniProtKB "As part of the nuclear pore complex (NPC), has a role in its assembly and function. (Microbial infection) Required for optimal replication of E.chaffeensis. (UniProtKB:Q9VBU8)" FBgn0039302 UniProtKB "E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:17682050, PubMed:27979731). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). (UniProtKB:A0A0B4K7J2)" FBgn0039303 Alliance "Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1)." FBgn0039305 Alliance "Predicted to enable DNA binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in rRNA processing. Predicted to be active in nucleus. Is expressed in adult head; adult heart; embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4)." FBgn0039306 Alliance "Predicted to enable protein kinase activity. Involved in positive regulation of glial cell proliferation. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Orthologous to human RIOK2 (RIO kinase 2)." FBgn0039310 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0051300 Alliance Predicted to enable ecdysteroid 22-kinase activity. Involved in cellular response to caffeine; detoxification; and xenobiotic metabolic process. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and posterior midgut primordium. FBgn0051104 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0039315 Alliance Predicted to enable ecdysteroid 22-kinase activity. Involved in cellular response to caffeine; detoxification; and xenobiotic metabolic process. FBgn0039316 Alliance Predicted to enable ecdysteroid 22-kinase activity. Involved in cellular response to caffeine; detoxification; and xenobiotic metabolic process. Is expressed in adult head. FBgn0039319 Alliance Predicted to enable ecdysteroid 22-kinase activity. Involved in cellular response to caffeine; detoxification; and xenobiotic metabolic process. FBgn0051370 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0051436 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in wing disc. FBgn0028647 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic/larval nervous system; ganglia; and midline primordium. Orthologous to several human genes including ZNF208 (zinc finger protein 208); ZNF212 (zinc finger protein 212); and ZNF671 (zinc finger protein 671)." FBgn0027376 FlyBase Gene Snapshot rha (rha) encodes a protein that is postmeiotically present in spermatid nuclei and might be involved in the chromatin substitution process removing histones from the chromatin during sperm development. FBgn0039335 FlyBase Gene Snapshot "Vacuolar protein sorting 33B (Vps33B) encodes a member of the family of SM proteins, which in conjunction with SNARE proteins catalyze membrane fusion events. The product of Vps33B, together with its binding partner encoded by Vps16B, forms a complex that is necessary for fusions between phagosomes and lysosomes." FBgn0039337 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (UniProtKB:Q9VBQ9)" FBgn0039338 FlyBase Gene Snapshot XNP (XNP) encodes two protein isoforms that participate in the maintenance of heterochromatin and chromosomal stability. They interact with heterochromatin proteins such as those encoded by Su(var)205 and ADD1. FBgn0039336 Alliance "Predicted to be active in nucleus. Is expressed in anterior endoderm; anterior midgut primordium; embryonic/larval midgut; organism; and posterior endoderm. Orthologous to human NGRN (neugrin, neurite outgrowth associated)." FBgn0039329 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic hindgut; embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human ZFP62 (ZFP62 zinc finger protein) and ZNF268 (zinc finger protein 268)." FBgn0039328 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult fat body; embryonic proventriculus; and embryonic/larval salivary gland. FBgn0045761 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0039326 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0039325 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult fat body and adult head. FBgn0039324 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head and organism. FBgn0039323 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0051087 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0051099 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0039321 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head and spermatozoon. FBgn0051288 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head and organism. FBgn0051097 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0051102 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0051098 Alliance "Predicted to enable ecdysteroid 22-kinase activity. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut interstitial cell; gut section; and wing disc." FBgn0039312 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0039311 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0027090 Alliance Predicted to enable glutamine-tRNA ligase activity. Involved in dendrite morphogenesis. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head and organism. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). FBgn0039304 Alliance "Predicted to enable 3-dehydrosphinganine reductase activity. Predicted to be involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic epipharynx; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase)." FBgn0039300 Alliance A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit assembly. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 17. Orthologous to several human genes including RPS27 (ribosomal protein S27). FBgn0000158 FlyBase Gene Snapshot "bag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway." FBgn0039296 UniProtKB Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family (By similarity). (UniProtKB:Q9VBV5) FBgn0039294 Alliance Predicted to enable calcium ion binding activity. Involved in open tracheal system development. Predicted to be active in plasma membrane. Is expressed in spiracular chamber. Orthologous to human PCDHB7 (protocadherin beta 7). FBgn0039291 Alliance Involved in protein quality control for misfolded or incompletely synthesized proteins. Is expressed in adult head. Orthologous to human SAYSD1 (SAYSVFN motif domain containing 1). FBgn0022800 FlyBase Gene Snapshot Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. FBgn0039339 Alliance Predicted to enable ribosome binding activity. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Orthologous to human GTPBP6 (GTP binding protein 6 (putative)). FBgn0039341 Alliance Predicted to enable acylglycerol lipase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Is expressed in adult head; adult heart; and organism. FBgn0039342 Alliance Is expressed in adult head and adult heart. FBgn0039343 Alliance Predicted to be involved in protein ubiquitination and regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). FBgn0011666 FlyBase Gene Snapshot "musashi (msi) encodes an RNA binding protein that binds to the 3' UTR region of target mRNAs, including ttk and sima, thus it positively regulates neural differentiation and negatively regulates the HIF pathway. It contributes to cell fate determination, as well as cellular response to normoxic/hypoxic conditions." FBgn0039347 Alliance Predicted to enable cyclosporin A binding activity; peptidyl-prolyl cis-trans isomerase activity; and zinc ion binding activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. Is expressed in spermatozoon. FBgn0039350 FlyBase Gene Snapshot jing interacting gene regulatory 1 (jigr1) encodes a nuclear protein that is differentially expressed in the embryonic central nervous system and highly expressed in neurons and glial cells in the larval nervous system. Its expression is downregulated in larval neuroblasts by the miR-92 family to maintain the neuroblast pool. FBgn0027508 FlyBase Gene Snapshot tankyrase (Tnks) encodes an ADP-ribose polymerase that regulates Wnt signalling by contributing to the degradation of Axn. FBgn0039344 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0040212 Alliance "Predicted to enable glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including ether lipid biosynthetic process; phospholipid biosynthetic process; and triglyceride biosynthetic process. Predicted to be located in peroxisome. Predicted to be active in mitochondrial membrane and peroxisomal membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase)." FBgn0039354 FlyBase Gene Snapshot "Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) encodes a protein activated by the relaxin-like hormone encoded by Ilp8, which coordinates organ growth." FBgn0039358 Alliance Predicted to enable enzyme activator activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). FBgn0039373 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. FBgn0039374 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. Is expressed in organism. FBgn0011273 UniProtKB May be involved in calcium-mediated signal transduction. (UniProtKB:P49258) FBgn0039379 Alliance "Predicted to enable syntaxin binding activity. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle cell; embryonic/larval muscle system; mesoderm; and somatic muscle primordium. Orthologous to human TXLNA (taxilin alpha); TXLNB (taxilin beta); and TXLNG (taxilin gamma)." FBgn0039380 Alliance Predicted to enable calcium ion binding activity. Involved in wing disc dorsal/ventral pattern formation. Is expressed in adult head. Orthologous to several human genes including KCNIP1 (potassium voltage-gated channel interacting protein 1); KCNIP2 (potassium voltage-gated channel interacting protein 2); and KCNIP3 (potassium voltage-gated channel interacting protein 3). FBgn0039381 Alliance "Enables aspartic endopeptidase activity, intramembrane cleaving. Involved in signal peptide processing. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human SPPL3 (signal peptide peptidase like 3)." FBgn0027865 Alliance "Located in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6 and prostate adenocarcinoma. Orthologous to human CD81 (CD81 molecule); CD9 (CD9 molecule); and TSPAN2 (tetraspanin 2)." FBgn0040602 Alliance Is expressed in germline cell; gonad; and organism. FBgn0011668 FlyBase Gene Snapshot Male-specific RNA 57Da (Mst57Da) encodes a peptide that is produced by the male accessory glands and transferred to females during mating. Its proline-rich peptide composition suggests a possible role as an antimicrobial peptide. FBgn0011669 FlyBase Gene Snapshot Male-specific RNA 57Db (Mst57Db) encodes a peptide produced by the male accessory glands and transferred to females during mating. FBgn0011670 FlyBase Gene Snapshot Male-specific transcript 57Dc (Mst57Dc) encodes a peptide produced by the male accessory glands and transferred to females during mating. FBgn0051380 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0039371 Alliance Predicted to be involved in regulation of intracellular transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Orthologous to human REEP5 (receptor accessory protein 5) and REEP6 (receptor accessory protein 6). FBgn0039368 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in adult head; embryonic/larval brain; embryonic/larval central nervous system; and organism. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0039367 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in embryonic/larval central nervous system and organism. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0066101 FlyBase Gene Snapshot Lipophorin receptor 1 (LpR1) encodes a transmembrane receptor that regulates immune response by mediating clearance of the protein encoded by nec from the hemolymph. Some of the LpR1-encoded isoforms are also involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. FBgn0051092 FlyBase Gene Snapshot Lipophorin receptor 2 (LpR2) encodes a transmembrane receptor. A subset of LpR2-encoded isoforms are involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. FBgn0039360 FlyBase Gene Snapshot "Cardiolipin synthase (CLS) encodes a protein that catalyzes the condensation of CDP-diacylglycerol and phosphatidylglycerol to cardiolipin, a specific phospholipid of mitochondria." FBgn0039359 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 16. Orthologous to human RPL27 (ribosomal protein L27). FBgn0039357 UniProtKB "Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May mediate the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity). (UniProtKB:Q9VBN7)" FBgn0039355 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human MAZ (MYC associated zinc finger protein) and ZNF692 (zinc finger protein 692). FBgn0028717 FlyBase Gene Snapshot "Lnk (Lnk) encodes a member of the SH2B family of adaptor proteins. It functions within the insulin signalling pathway as an intracellular adaptor for the insulin receptor. It stabilises the interaction between the activated insulin receptor and the insulin receptor substrate, which are encoded by InR and chico respectively." FBgn0039385 Alliance "Predicted to enable RNA binding activity. Predicted to be located in cytoplasm and nucleus. Predicted to be part of tRNA-splicing ligase complex. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval nervous system; and ganglia. Orthologous to several human genes including FAM98A (family with sequence similarity 98 member A) and FAM98B (family with sequence similarity 98 member B)." FBgn0039386 Alliance "Predicted to enable copper ion binding activity. Predicted to be involved in superoxide metabolic process. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3)." FBgn0039387 FlyBase Gene Snapshot Multicopper oxidase 3 (Mco3) encodes a multi-copper oxidase enzyme that is located in the cellular secretory pathway. It is developmentally regulated and has been proposed to affect iron and copper homeostasis. FBgn0051091 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0051089 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J)." FBgn0039398 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in adult head and spermatozoon. FBgn0000206 UniProtKB Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. (UniProtKB:P22815) FBgn0002734 UniProtKB "Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm (PubMed:28899667). (UniProtKB:Q01071)" FBgn0002735 UniProtKB "Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:24618901). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). Part of the Notch signaling pathway, plays a role in neuroblasts proliferation in embryos and larvae (PubMed:10790334, PubMed:22357926). In the larval brain, together with other self-renewal transcriptional repressors such as klu and dpn, required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) derived from type II neuroblasts (PubMed:24618901). (UniProtKB:Q01070)" FBgn0002732 FlyBase Gene Snapshot "Enhancer of split malpha, Bearded family member (E(spl)malpha-BFM) encodes one of the basic helix-loop-helix (bHLH) transcription factors that are responsive to Notch signaling. It is involved in cellular processes downstream of Notch signaling such as cell fate specification and sensory organ development." FBgn0002578 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; gut section; procrystal cell; and yolk nucleus." FBgn0002609 FlyBase Gene Snapshot "Enhancer of split m3, helix-loop-helix (E(spl)m3-HLH) is a member the enhancer of split gene (E(spl)) complex. E(spl)m3-HLH encodes a transcriptional repressor executing Notch-mediated cellular differentiation." FBgn0002633 UniProtKB Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (UniProtKB:P13097) FBgn0000591 UniProtKB Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo (PubMed:2540957). Transcriptional repressor (PubMed:8001118). Binds DNA on N-box motifs: 5'-CACNAG-3' (PubMed:8001118). Part of the Notch signaling pathway (PubMed:22357926). (UniProtKB:P13098) FBgn0001139 FlyBase Gene Snapshot "groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity." FBgn0039402 FlyBase Gene Snapshot Vacuolar protein sorting 2 (Vps2) encodes a component of the ESCRT-III complex which is required for endosome-mediated trafficking via multivesicular body formation and sorting. FBgn0039404 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 14 with mandibulofacial dysostosis. Orthologous to human TSR2 (TSR2 ribosome maturation factor)." FBgn0039407 Alliance Predicted to enable tRNA (adenine(58)-N1)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). FBgn0039411 FlyBase Gene Snapshot "dysfusion (dysf) encodes a transcription factor that forms a DNA binding complex with the product of tgo to activate target genes. It is involved in in migration, adhesion, and fusion of tracheal cells, as well as tarsal joint formation during leg development." FBgn0039408 Alliance Orthologous to human CFAP97D1 (CFAP97 domain containing 1) and CFAP97D2 (CFAP97 domain containing 2). FBgn0039406 Alliance Enables myosin binding activity. A structural constituent of ribosome. Predicted to be involved in ribosome biogenesis and translation. Located in cytosolic ribosome. Is expressed in adult head and organism. Orthologous to human RPL34 (ribosomal protein L34). FBgn0039405 Alliance Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Orthologous to human PIGP (phosphatidylinositol glycan anchor biosynthesis class P). FBgn0039403 FlyBase Gene Snapshot "Sld5 (Sld5) encodes a subunit of the Cdc45/Mcm2-7/GINS (CMG) complex, which is associated with an ATP-dependent DNA helicase function and is involved in the regulation of the mitotic G1/S transition." FBgn0028833 FlyBase Gene Snapshot Dak1 (Dak1) encodes a mitochondrial pyrimidine nucleoside monophosphate kinase with cytidylate kinase and uridylate kinase activity. FBgn0002629 UniProtKB Part of the Notch signaling pathway. (UniProtKB:P13095) FBgn0002592 UniProtKB Part of the Notch signaling pathway. (UniProtKB:O97177) FBgn0002733 UniProtKB Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). Part of the Notch signaling pathway (PubMed:1427040). (UniProtKB:Q01069) FBgn0039415 Alliance Predicted to enable oxidoreductase activity. Orthologous to human CHDH (choline dehydrogenase). FBgn0051323 Alliance Is expressed in embryonic midgut chamber and embryonic/larval midgut. FBgn0051086 Alliance Is expressed in adult head. FBgn0039419 Alliance "Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway and positive regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in organism; spermatozoon; and yolk nucleus." FBgn0039420 Alliance Predicted to enable metallodipeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to several human genes including DPEP1 (dipeptidase 1). FBgn0000064 FlyBase Gene Snapshot "Aldolase 1 (Ald1) encodes an enzyme that catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate into dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate, and thus plays an essential role in glycolysis and gluconeogenesis. It also catalyzes the conversion of beta-D-fructose 1-phosphate into dihydroxyacetone phosphate and D-glyceraldehyde and plays a role in fructose catabolism." FBgn0039417 Alliance Is expressed in organism. Orthologous to human HGH1 (HGH1 homolog). FBgn0039425 FlyBase Gene Snapshot "Aldolase 2 (Ald2) encodes a testis-specific enzyme that catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate into dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate and plays an essential role in glycolysis and gluconeogenesis. It also catalyzes the conversion of beta-D-fructose 1-phosphate into dihydroxyacetone phosphate and D-glyceraldehyde and plays a role in fructose catabolism." FBgn0042711 FlyBase Gene Snapshot Hexokinase testis 1 (Hex-t1) is predicted to encode a testis-specific enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexose to hexose 6-phosphate. It may mediate the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate. FBgn0042710 FlyBase Gene Snapshot Hexokinase testis 2 (Hex-t2) is predicted to encode a testis-specific enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexose to hexose 6-phosphate. It may mediate the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate. FBgn0039427 Alliance Predicted to be involved in Golgi to plasma membrane protein transport and protein targeting to membrane. Predicted to be located in Golgi membrane. Predicted to be part of palmitoyltransferase complex. Is expressed in adult head and organism. Orthologous to human GOLGA7 (golgin A7) and GOLGA7B (golgin A7 family member B). FBgn0039429 Alliance Orthologous to human TMEM26 (transmembrane protein 26). FBgn0039430 Alliance "Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular matrix. Is expressed in dorsal head epidermis; embryonic dorsal epidermis; embryonic head epidermis; embryonic head sensory system; and embryonic ventral epidermis. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1)." FBgn0039431 FlyBase Gene Snapshot plum (plum) encodes an Ig-superfamily transmembrane protein. It is required for developmental pruning of both mushroom body neurons and motor neurons via TGF-beta signaling. plum genetically interacts with myo and babo. FBgn0023178 FlyBase Gene Snapshot "Pigment-dispersing factor (Pdf) encodes a secreted biologically active neuropeptide that acts via a specific G-protein-coupled receptor to trigger intracellular signaling. It has a prominent role in the physiology of circadian rhythms, as well as contributing to other processes such as control of flight and digestion." FBgn0039424 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0039421 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of stress-activated MAPK cascade. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) and PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)." FBgn0039434 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and organism. FBgn0039440 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Located in chitin-based extracellular matrix. FBgn0039441 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0051080 Alliance A structural constituent of chitin-based larval cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. FBgn0051081 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0039443 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0039444 FlyBase Gene Snapshot TweedleD (TwdlD) encodes a chitin-binding protein that is a member of the Tweedle family of cuticle proteins. FBgn0040607 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0039453 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0039451 Alliance Involved in negative regulation of ubiquitin-dependent protein catabolic process and positive regulation of canonical Wnt signaling pathway. Part of peptidase complex. Is expressed in adult head and organism. Orthologous to several human genes including WDR20 (WD repeat domain 20). FBgn0039449 Alliance Is expressed in organism. FBgn0023179 FlyBase Gene Snapshot "amontillado (amon) encodes a member of the Prohormone Convertase (PC) family of proteolytic enzymes. PCs generally recognize conserved basic amino acid sequences within protein precursors to direct catalysis of specific cleavage. amon product directly cleaves sli protein and may also target the propeptide encoded by Akh. It is also required for the production of bioactive neuropeptide hormones (e.g. those encoded by Hug, Crz, Ms, Capa and sNPF)." FBgn0039448 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0039439 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0039438 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0039437 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0039436 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis and embryonic ventral epidermis. FBgn0039435 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. FBgn0039459 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424, PubMed:23288851). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS1 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9VBB3)" FBgn0001197 FlyBase Gene Snapshot Histone H2A variant (His2Av) encodes a protein that is present in about 25% of nucleosomes. It influences chromatin structure and gene regulation and is also phosphorylated in response to DNA damage in the less conserved C-terminal tail. FBgn0002838 FlyBase Gene Snapshot male sterile (3) K81 (ms(3)K81) encodes a telomere capping protein that is required to protect sperm telomeres from end-to-end fusion at fertilization. The ms(3)K81 product replaces its paralog HipHop in post-meiotic male germ cell nuclei. FBgn0039461 Alliance Orthologous to human OXLD1 (oxidoreductase like domain containing 1). FBgn0004359 FlyBase Gene Snapshot "Transcript 48 (T48) encodes a protein with a predicted signal peptide and a potential transmembrane domain. During gastrulation, the product of T48 contributes to apical constriction by recruitment of the Rho GEF encoded by RhoGEF2 to the apical cell membrane and functions downstream of the transcription factor encoded by twi." FBgn0039462 Alliance Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. FBgn0039463 Alliance Predicted to enable heat shock protein binding activity. Predicted to be involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial outer membrane and nucleus. Predicted to be active in cytosol and mitochondrion. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 28. Orthologous to human SPAG1 (sperm associated antigen 1). FBgn0039466 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). FBgn0039467 Alliance "Is expressed in several structures, including antennal primordium; dorsal sensory complex primordium; gland; sense organ; and sensory nervous system primordium." FBgn0039469 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic epipharynx; embryonic foregut; and embryonic hypopharynx. FBgn0051077 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0039471 Alliance "Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0039470 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0051076 Alliance Human ortholog(s) of this gene implicated in oculocutaneous albinism type VII. Orthologous to human LRMDA (leucine rich melanocyte differentiation associated). FBgn0051075 Alliance Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in pyruvate metabolic process. Predicted to be located in mitochondrion. Is expressed in adult brain; adult head; adult pars intercerebralis; and organism. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1) and ALDH1A2 (aldehyde dehydrogenase 1 family member A2). FBgn0041224 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IMQ6)" FBgn0039465 Alliance Predicted to be located in membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human TSPAN13 (tetraspanin 13) and TSPAN31 (tetraspanin 31). FBgn0039464 Alliance Predicted to enable uridine phosphorylase activity. Involved in gravitaxis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human UPP1 (uridine phosphorylase 1) and UPP2 (uridine phosphorylase 2). FBgn0051070 Alliance Predicted to enable CAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051071 Alliance Predicted to enable CAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0004510 UniProtKB May have a role in germline development. (UniProtKB:Q04688) FBgn0003267 UniProtKB Required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk. Repression of expression in R8 photoreceptor by senseless (sens) is an essential mechanism of R8 cell fate determination. (UniProtKB:P10181) FBgn0026562 FlyBase Gene Snapshot "Secreted protein, acidic, cysteine-rich (SPARC) encodes a small calcium and growth factor-binding secreted glycoprotein that is enriched in basement membranes. During cell competition, it is expressed in ""loser"" cells so they can avoid apoptosis mediated by the products of fwe and azot." FBgn0027889 FlyBase Gene Snapshot "ballchen (ball) encodes a nuclear serine/threonine kinase that regulates chromatin organization through phosphorylation of the product of baf. It contributes to stem cell maintenance in various tissues, as well as chromosome condensation and segregation in meiosis." FBgn0004842 UniProtKB "Receptor for the neuropeptides RYamide-1 and RYamide-2 (PubMed:21704020, PubMed:21843505). The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system (PubMed:21704020, PubMed:21843505). RYamide signaling may suppress feeding behavior (PubMed:21704020). (UniProtKB:P25931)" FBgn0029170 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic hypopharynx; embryonic/larval posterior spiracle; and larval foregut atrium." FBgn0039479 Alliance Is expressed in adult head. FBgn0039482 Alliance Predicted to be active in extracellular space. FBgn0039483 Alliance Predicted to be active in extracellular space. FBgn0039485 Alliance Predicted to be active in extracellular space. Is expressed in adult head. FBgn0027574 Alliance Predicted to enable DNA binding activity and histone binding activity. Predicted to be involved in nucleosome assembly and transcription by RNA polymerase I. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human SPTY2D1 (SPT2 chromatin protein domain containing 1). FBgn0039489 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Located in Golgi apparatus. Is expressed in adult head; embryonic/larval central nervous system; and organism. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). FBgn0039490 Alliance Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in spermatogenic failure 49. Orthologous to human CFAP58 (cilia and flagella associated protein 58). FBgn0029155 Alliance "Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in glucose homeostasis. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including adult head; adult heart; ganglia; gut section; and nephrocyte. Orthologous to several human genes including ME3 (malic enzyme 3)." FBgn0039494 FlyBase Gene Snapshot "Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz." FBgn0039495 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0051065 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0003482 FlyBase Gene Snapshot spindle D (spn-D) encodes a DNA repair protein required for homologous recombinational DNA repair. It functions in meiotic recombination. FBgn0005696 UniProtKB "Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:6403945, PubMed:6409898, PubMed:6773966, PubMed:7592543). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). (UniProtKB:Q9VB62)" FBgn0039498 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein polyubiquitination and regulation of mitochondrial fission. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). FBgn0042111 Alliance "Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval nervous system; ganglia; gnathal primordium; and mesoderm. Orthologous to human MSANTD1 (Myb/SANT DNA binding domain containing 1)." FBgn0051064 Alliance Enables small GTPase binding activity. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including RUFY1 (RUN and FYVE domain containing 1). FBgn0004197 UniProtKB Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues. (UniProtKB:P18168) FBgn0039492 UniProtKB Negative regulator of epidermal growth factor receptor (EGFR) signaling. (UniProtKB:Q9VB70) FBgn0039491 Alliance Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in spermatogenic failure 49. Orthologous to human CFAP58 (cilia and flagella associated protein 58). FBgn0039488 Alliance Predicted to enable chromatin binding activity. Predicted to be involved in regulation of gene expression. Part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to several human genes including NKAP (NFKB activating protein). FBgn0039487 FlyBase Gene Snapshot genderblind (gb) encodes an amino acid transporter involved in glutamate secretion into the extracellular space. It regulates synaptic transmission and male courtship behavior by altering glutamate receptor abundance in the nervous system. FBgn0039486 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA14 (carbonic anhydrase 14); CA4 (carbonic anhydrase 4); and CA6 (carbonic anhydrase 6). FBgn0039481 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in dorsal pharyngeal muscle cell and embryonic/larval posterior spiracle. FBgn0039480 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in dorsal head epidermis and larval foregut atrium. FBgn0003495 FlyBase Gene Snapshot "spatzle (spz) encodes a secreted protein which, after cleavage by an extracellular serine protease (encoded by ea or SPE), can induce the dimerization of the product of Tl, and the subsequent activation of the Toll pathway. It contributes to function of the Toll signaling cascade, which plays a key role in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptides." FBgn0039478 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain and spermatozoon. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039476 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0039475 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0039474 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0039473 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0039472 Alliance "Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0011289 FlyBase Gene Snapshot "Transcription factor IIA L (TfIIA-L) encodes a precursor protein that, after proteolysis, produces the two larger subunits of TFIIA. TFIIA is a general transcription factor that is required for initiation by RNA polymerase II and is a component of the pre-initiation complex." FBgn0039504 Alliance Involved in adult somatic muscle development. FBgn0039505 Alliance Predicted to colocalize with trans-Golgi network. Is expressed in organism. Orthologous to human SCOC (short coiled-coil protein). FBgn0046247 Alliance Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including CHIC2 (cysteine rich hydrophobic domain 2). FBgn0039508 Alliance Predicted to be involved in tRNA methylation. FBgn0015737 UniProtKB "Transmembrane mucin that may be involved in cellular adhesion and the innate immune response (PubMed:12769978, PubMed:8662683). Membrane-tethered mucins are involved in many cell surface functions and form a physical barrier around cells to regulate cell-cell and/or cell-substrate interactions, and protect against pathogens or harmful extracellular conditions (PubMed:11164341, PubMed:12769978, PubMed:8662683). This mucin likely acts in hemocyte adhesion as it is released from hemocytes during coagulation and is also able to bind lipophorin particles which form part of the hemocyte coagulogen (PubMed:12769978). Able to induce expression of the antibacterial proteins in the presence of GalNAc-specific lectins and so probably also functions in the innate immune response (PubMed:8662683). (UniProtKB:Q9VB46)" FBgn0016061 FlyBase Gene Snapshot "sidestep (side) encodes a transmembrane protein of the immunoglobulin superfamily that is expressed in a defined spatiotemporal pattern in glial cells, sensory neurons and muscles. It functions as an attractive guidance cue to guide motor axons to their target regions." FBgn0039511 Alliance Is expressed in early elongation stage spermatid; early-mid elongation-stage spermatid; pre-elongation spermatid; and primary spermatocyte. FBgn0039510 Alliance Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium and axoneme. Is expressed in antenna; chordotonal neurons; and spermatozoon. Human ortholog(s) of this gene implicated in Kartagener syndrome; primary ciliary dyskinesia 40; and primary ciliary dyskinesia 7. Orthologous to several human genes including DNAH9 (dynein axonemal heavy chain 9). FBgn0040609 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0039509 FlyBase Gene Snapshot "bigmax (bigmax) encodes a basic helix-loop-helix-leucine zipper transcription factor. Together with its binding partner encoded by Mondo, the product of bigmax is involved in sugar-dependent gene regulation. It is involved in transcriptional control of many metabolic pathways, including glycolysis, de novo lipogenesis and the pentose phosphate pathway. Loss of bigmax function produces dietary sugar intolerance." FBgn0039507 Alliance "Enables transcription cis-regulatory region binding activity. Involved in negative regulation of DNA-templated transcription and regulation of chromatin organization. Located in nucleus. Is expressed in several structures, including embryonic/larval central nervous system; gland; larval insulin secreting cell of pars intercerebralis; larval ventral nerve cord; and spermatozoon." FBgn0002441 FlyBase Gene Snapshot "lethal (3) malignant brain tumor (l(3)mbt) encodes a tumor suppressor protein regulating proliferation in the brain, particularly the optic lobes. The proposed functions of the product of l(3)mbt include histone compaction, establishment of chromatin insulators, regulation of the Hippo pathway and repression of the germ line program in somatic cells." FBgn0039503 Alliance Is expressed in spermatozoon. FBgn0010328 FlyBase Gene Snapshot "without children (woc) encodes a chromatin-binding factor related to the mammalian MYM-type family of transcription factors. It is involved in telomere capping, regulation of transcription, ecdysone biosynthesis and germline stem cell differentiation." FBgn0010441 FlyBase Gene Snapshot "Pelle (pll) encodes a tyrosine kinase-like family serine-threonine protein kinase that functions in the Toll pathway, a signaling cascade that plays key roles in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptide production." FBgn0039501 Alliance Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cilium. Orthologous to several human genes including TTLL6 (tubulin tyrosine ligase like 6). FBgn0039500 Alliance Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B). FBgn0039518 Alliance Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). FBgn0039519 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VB31) FBgn0039520 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9VB30)" FBgn0039523 Alliance Predicted to be part of Set1C/COMPASS complex. FBgn0046887 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9VB26)" FBgn0046886 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IMN6)" FBgn0046885 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q8IMN5)" FBgn0040080 FlyBase Gene Snapshot partner of inscuteable (pins) encodes a GDP-dissociation inhibitor involved in asymmetric cell division and mitotic spindle orientation. FBgn0039528 Alliance Enables ubiquitin protein ligase binding activity. Involved in synaptic target recognition. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in adult head. Orthologous to human ATRN (attractin) and ATRNL1 (attractin like 1). FBgn0039527 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell-matrix adhesion. Predicted to be located in extracellular region. Predicted to be active in basement membrane and extracellular space. Is expressed in adult fat body. Orthologous to several human genes including WFDC10A (WAP four-disulfide core domain 10A); WFDC10B (WAP four-disulfide core domain 10B); and WFDC11 (WAP four-disulfide core domain 11). FBgn0027492 FlyBase Gene Snapshot "widerborst (wdb) encodes a B' regulatory subunit of the serine/threonine phosphatase complex PP2A. It regulates Hedgehog, protein kinase B and insulin receptor signaling pathways." FBgn0039525 Alliance Predicted to enable high-affinity L-arginine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human SLC25A45 (solute carrier family 25 member 45). FBgn0004387 UniProtKB "Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188). Also plays a role in regulation of autophagosome formation, fusion and positioning and is required for normal localization of Rab14 (PubMed:26763909). (UniProtKB:Q9VB25)" FBgn0039522 Alliance Predicted to be involved in cilium organization. Predicted to be active in cytoplasm and motile cilium. Is expressed in chordotonal neurons. Orthologous to human IQCG (IQ motif containing G). FBgn0039521 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0005659 FlyBase Gene Snapshot Ets at 98B (Ets98B) encodes a protein belonging to the Ets family of transcription factors. Ets98B is specifically expressed in oocyte nucleus during oogenesis and in primordial germ cells before the onset of germ cell migration. FBgn0039551 FlyBase Gene Snapshot Odorant receptor 98a (Or98a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0039555 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head and spermatozoon. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 5 and ovarian dysgenesis 7. Orthologous to human MRPS22 (mitochondrial ribosomal protein S22). FBgn0003279 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; organism; and spermatozoon. Orthologous to human RPL4 (ribosomal protein L4). FBgn0027579 FlyBase Gene Snapshot "minotaur (mino) encodes a member of the conserved glycerol-3-phosphate O-acyltransferase family, which converts glycerol-3-phosphate into lysophosphatidic acid. It functions in phosphatidic acid biosynthesis. It is also essential for piRNA biogenesis in gonads, with mino mutants showing transposon de-repression and sterility phenotypes." FBgn0039560 Alliance Involved in nonassociative learning and synaptic assembly at neuromuscular junction. Predicted to be part of Set1C/COMPASS complex. Is expressed in embryonic/larval salivary gland and organism. Used to study intellectual disability. Orthologous to several human genes including BOD1 (biorientation of chromosomes in cell division 1) and BOD1L2 (biorientation of chromosomes in cell division 1 like 2). FBgn0039562 FlyBase Gene Snapshot Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. FBgn0039564 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039566 Alliance "Predicted to enable GTPase activity; U5 snRNA binding activity; and translation elongation factor activity. Predicted to be involved in mRNA splicing, via spliceosome and translational elongation. Located in cytoplasm. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in esophageal atresia; hepatitis B; hepatocellular carcinoma; mandibulofacial dysostosis, Guion-Almeida type; and microcephaly. Orthologous to human EFTUD2 (elongation factor Tu GTP binding domain containing 2)." FBgn0039568 Alliance Predicted to enable serine-type endopeptidase activity. Involved in sexual reproduction. Located in extracellular space. FBgn0003890 FlyBase Gene Snapshot beta-Tubulin at 97EF (betaTub97EF) is one of five distinct paralogs that codes for a beta-tubulin protein. beta-tubulin protein can polymerize into microtubules after heterodimerization with an alpha-tubulin protein. betaTub97EF expression is tissue-specific and up-regulated at low temperature. Microtubules containing this beta-tubulin are relatively stable. FBgn0039565 Alliance Predicted to enable RNA binding activity. Predicted to be involved in regulation of mitochondrial transcription. Predicted to be active in mitochondrion. Orthologous to human MTRES1 (mitochondrial transcription rescue factor 1). FBgn0039563 Alliance "Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; gut section; head epidermis primordium; and mesoderm." FBgn0039561 UniProtKB Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly. (UniProtKB:Q9VAY3) FBgn0039559 UniProtKB Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity). (UniProtKB:Q8MT36) FBgn0051053 UniProtKB Required for the formation of DNA double-strand breaks together with narya and vilya during the meiotic recombination process (PubMed:30615609). Plays a redundant role with narya in chromosome segregation during female meiosis (PubMed:30615609). (UniProtKB:Q8IMM9) FBgn0039558 FlyBase Gene Snapshot BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling. FBgn0039557 Alliance Predicted to enable RNA binding activity. Predicted to be involved in chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Armfield syndrome. Orthologous to human FAM50A (family with sequence similarity 50 member A) and FAM50B (family with sequence similarity 50 member B). FBgn0053213 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of pericentric heterochromatin. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and ventral ectoderm." FBgn0039554 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human FBXL12 (F-box and leucine rich repeat protein 12). FBgn0002865 Alliance Involved in spermatid development. Located in sperm flagellum. Is expressed in adult head and spermatozoon. FBgn0004171 Alliance Involved in spermatid development. Located in sperm flagellum. Is expressed in spermatozoon. FBgn0039576 Alliance Involved in determination of adult lifespan; mitochondrial respiratory chain complex III assembly; and response to reactive oxygen species. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex III deficiency nuclear type 3. Orthologous to human UQCRB (ubiquinol-cytochrome c reductase binding protein). FBgn0039581 FlyBase Gene Snapshot Moca-cyp (Moca-cyp) encodes a peptidyl-prolyl cis-trans isomerase. FBgn0039584 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in membrane. FBgn0039585 Alliance "Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region. Part of euchromatin. Orthologous to human KAT8 (lysine acetyltransferase 8)." FBgn0013813 Alliance Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility. Is active in sperm flagellum. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Used to study obesity. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). FBgn0039588 Alliance Predicted to enable GTPase activity; tRNA binding activity; and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). FBgn0003137 FlyBase Gene Snapshot "Papilin (Ppn) encodes a secreted sulfated glycoprotein which is part of basement membranes and provisional extracellular matrices. Ppn regulates muscle patterning, but not muscle differentiation." FBgn0039580 FlyBase Gene Snapshot "Glutamine:fructose-6-phosphate aminotransferase 2 (Gfat2) encodes an enzyme that catalyzes the transamination of fructose 6-phosphate to D-glucosamine 6-phosphate. It is involved in the biosynthesis of UDP-N-acetylglucosamine, a precursor for chitin biosynthesis and protein glycosylation." FBgn0001215 FlyBase Gene Snapshot "Heterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate." FBgn0039589 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval garland cell; garland cell primordium; pole plasm; and posterior ectoderm anlage. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 66. Orthologous to human FERRY3 (FERRY endosomal RAB5 effector complex subunit 3)." FBgn0053346 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). FBgn0039593 FlyBase Gene Snapshot Stress induced DNase (Sid) encodes a protein belonging to an evolutionarily conserved enzyme family that degrades both single and double stranded nucleic acids. Sid expression is highly induced by bacterial infection and oxidative stress. Its apparent role is to protect from the toxic effects of excess DNA/RNA released by a vigorous immune response. FBgn0039594 Alliance "Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Involved in cuticle development. Located in apical plasma membrane and cytoplasmic vesicle. Is expressed in several structures, including adult head; embryonic anal pad; embryonic head epidermis; epithelium; and gut section." FBgn0027655 FlyBase Gene Snapshot "huntingtin (htt) encodes a scaffold protein involved in mitotic spindle orientation, chromatin regulation and axonal transport. It is the ortholog of human HTT and has been manipulated to study Huntington's disease in flies." FBgn0039599 Alliance "Predicted to enable serine-type endopeptidase activity. Involved in negative regulation of female receptivity, post-mating; sexual reproduction; and sperm storage. Predicted to be located in extracellular region. Is expressed in ejaculatory bulb and male accessory gland." FBgn0039598 FlyBase Gene Snapshot aquarius (aqrs) encodes a predicted serine protease produced by the male accessory glands and transferred to females during mating. It is required for the binding of the product of SP to sperm and for the transfer of the products of lectin-46Ca and lectin-46Cb to females during mating. FBgn0039597 FlyBase Gene Snapshot "CG9997 encodes a protein with homology to serine-type endopeptidases, but is not predicted to have catalytic activity due to mutations in its active site. It is produced in the male accessory gland and transferred to females during mating. In males, it is required for other seminal proteins to be transferred to mated females. In mated females, it is required for the binding of the product of SP to sperm and for the maintenance of long-term post-mating responses." FBgn0039596 UniProtKB "May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. (UniProtKB:Q8MYY6)" FBgn0039595 FlyBase Gene Snapshot Allatostatin A receptor 2 (AstA-R2) encodes a receptor of the neuropeptide encoded by AstA. The interaction of both proteins modulates insulin and AKH signaling from cells of the corpus cardiaca. FBgn0039590 Alliance Orthologous to human ANKRD50 (ankyrin repeat domain containing 50). FBgn0026400 Alliance "Predicted to enable zinc ion binding activity. Involved in larval lymph gland hemopoiesis. Predicted to be located in chromosome, centromeric region; midbody; and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; embryonic anal pad; embryonic/larval midgut cell; embryonic/larval midgut primordium; and gland. Orthologous to human ZNF330 (zinc finger protein 330)." FBgn0000659 FlyBase Gene Snapshot "fork head (fkh) encodes a winged-helix nuclear transcription factor most studied for its role in salivary gland formation, where it is required for salivary gland viability, invagination, and maintaining expression of other early-expressed salivary gland transcription factors. It works with the product of sage to activate expression of salivary gland specific gene products, such as secreted proteins and their modifying enzymes." FBgn0039600 UniProtKB Involved in pre-mRNA splicing. (UniProtKB:Q7KRW8) FBgn0039602 Alliance Predicted to enable chromatin insulator sequence binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in chromosome. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval muscle system; and organism. FBgn0039609 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039611 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039613 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0027578 Alliance Predicted to be involved in proteolysis. Located in extracellular region. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0039616 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in sexual reproduction. Predicted to be active in endoplasmic reticulum. FBgn0039623 Alliance Predicted to enable ATP binding activity. Involved in sexual reproduction. Is expressed in adult head. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-4. Orthologous to human SCYL2 (SCY1 like pseudokinase 2). FBgn0041780 Alliance Predicted to enable arylesterase activity. Predicted to be involved in biosynthetic process. Orthologous to human APMAP (adipocyte plasma membrane associated protein). FBgn0039622 FlyBase Gene Snapshot eukaryotic translation initiation factor 4E6 (eIF4E6) encodes a RNA 7-methylguanosine cap binding protein. FBgn0039620 FlyBase Gene Snapshot "waterproof (wat) encodes a fatty acyl-CoA reductase that reduces very long chain fatty acids of 24 and 26 carbon atoms. It is essential for gas filling of the embryonic tracheal system and for the formation of the outermost tracheal cuticle sublayer, the envelope." FBgn0039617 FlyBase Gene Snapshot "Dpr-interacting protein gamma (DIP-gamma) encodes a single-pass membrane protein expressed in the larval ventral nerve chord and pupal and adult optic lobe. It is required for synaptic development and survival, and interacts with the product of dpr11 to guide synaptic connectivity in the optic lobe." FBgn0053203 Alliance Predicted to enable signaling receptor activity. Predicted to be located in membrane. Orthologous to human PAQR4 (progestin and adipoQ receptor family member 4). FBgn0039612 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0015589 FlyBase Gene Snapshot "APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development." FBgn0024273 FlyBase Gene Snapshot "WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis." FBgn0039601 Alliance Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in organism. Orthologous to human DCAF10 (DDB1 and CUL4 associated factor 10). FBgn0005642 UniProtKB May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte. (UniProtKB:P15619) FBgn0027873 UniProtKB "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. (UniProtKB:Q9V3D6)" FBgn0003093 FlyBase Gene Snapshot "Protein C kinase 98E (Pkc98E) encodes a serine-threonine protein kinase activated by calcium, membrane translocation and lipids (such as diacylglycerol and phorbol ester). Pkc98E product controls cytoskeleton by negatively regulating the F-actin bundling protein encoded by sn." FBgn0039627 UniProtKB "Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. (UniProtKB:Q9VAQ5)" FBgn0039628 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0039629 Alliance Predicted to enable serine-type endopeptidase activity. Involved in response to endoplasmic reticulum stress. FBgn0039630 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0039631 UniProtKB NAD-dependent protein deacetylase. (UniProtKB:Q9VAQ1) FBgn0039633 Alliance Involved in chromatin remodeling. Part of brahma complex. Is expressed in lobula; lobula plate; medulla; transmedullary Y neuron TmY27; and transmedullary neuron Tm27. Used to study Coffin-Siris syndrome. Orthologous to human BICRAL (BICRA like chromatin remodeling complex associated protein). FBgn0039635 UniProtKB The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity). Might play a role in regulating synapse structure formation at neuromuscular junctions (PubMed:29501567). Might play a role in maintenance of mitochondrial morphology (PubMed:29501567). (UniProtKB:Q7K5K3) FBgn0039636 FlyBase Gene Snapshot Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. FBgn0039637 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and dorsal median cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to several human genes including SLC44A2 (solute carrier family 44 member 2 (CTL2 blood group)) and SLC44A5 (solute carrier family 44 member 5). FBgn0028671 FlyBase Gene Snapshot "Vacuolar H[+] ATPase 100kD subunit 1 (Vha100-1) encodes a subunit of the V0 domain of V-ATPase, which acidifies autophagosomes and lysosomes in neurons. The product of Vha100-1 is involved in autophagosome maturation, tracheal branching and eye development." FBgn0039640 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic anal pad; germline cell; gonad; and indirect flight muscle cell. Orthologous to human ANPEP (alanyl aminopeptidase, membrane)." FBgn0028692 UniProtKB Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (UniProtKB:Q9V3P6) FBgn0039644 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; gland; gut section; imaginal disc; and nephrocyte. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group))." FBgn0039645 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0014427 UniProtKB Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. (UniProtKB:Q9VAN0) FBgn0051044 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in embryonic/larval salivary gland; embryonic/larval salivary gland body; and organism. FBgn0029176 FlyBase Gene Snapshot "eukaryotic translation elongation factor 1 gamma (eEF1gamma) encodes a protein that associates with other EF1 subunits (alpha/beta/delta). It regulates organelle movement along microtubules. It binds tubulin and the protein kinase encoded by Doa, which in turns phosphorylates the product of eEF1gamma." FBgn0039654 Alliance Involved in DNA repair-dependent chromatin remodeling and negative regulation of gene expression. Part of NuA4 histone acetyltransferase complex. Is expressed in spermatozoon. Orthologous to human BRD8 (bromodomain containing 8). FBgn0028476 Alliance Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in organism. Orthologous to human USP1 (ubiquitin specific peptidase 1). FBgn0003525 UniProtKB This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity. (UniProtKB:P20483) FBgn0051445 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to several human genes including ANPEP (alanyl aminopeptidase, membrane)." FBgn0039656 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane)." FBgn0039655 Alliance Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion; lipid catabolic process; and phospholipid metabolic process. Human ortholog(s) of this gene implicated in cholecystolithiasis; colorectal cancer; familial benign fleck retina; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Orthologous to several human genes including PLA2G2A (phospholipase A2 group IIA); PLA2G2D (phospholipase A2 group IID); and PLA2G2E (phospholipase A2 group IIE). FBgn0062442 Alliance "Predicted to enable 2 iron, 2 sulfur cluster binding activity. Involved in intracellular iron ion homeostasis and mitochondrial transport. Located in mitochondrial outer membrane. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to several human genes including CISD2 (CDGSH iron sulfur domain 2)." FBgn0039651 Alliance "Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in adult head; spermatozoon; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1)." FBgn0039650 FlyBase Gene Snapshot "Metazoan SpoT homolog-1 (Mesh1) encodes a structural and functional ortholog of bacterial protein SpoT. It hydrolyzes ppGpp to GDP. Its mutants show retarded growth in amino acid-starved media, suggesting the conserved role in stringent responses." FBgn0039647 FlyBase Gene Snapshot "julius seizure (jus) encodes a two-transmembrane domain protein expressed in selected neurons in the optic lobe, subesophageal and thoracic-abdominal ganglia. It is mainly localized to axons and its developmental expression prevents epileptogenesis." FBgn0041186 FlyBase Gene Snapshot Stem-loop binding protein (Slbp) encodes a protein that plays an essential role in 3' end processing of histone pre-mRNAs into mature histone mRNAs by recruiting the product of snRNA:U7 to the pre-mRNA. FBgn0041588 Alliance "Predicted to enable translation initiation factor activity. Predicted to be involved in formation of translation preinitiation complex and ribosome disassembly. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D)." FBgn0039641 Alliance Predicted to enable UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity. Predicted to be involved in UDP-N-acetylglucosamine transmembrane transport. Located in Golgi medial cisterna. Is expressed in embryonic epipharynx; embryonic hypopharynx; and organism. Orthologous to human SLC35B4 (solute carrier family 35 member B4). FBgn0039639 Alliance Predicted to enable N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Is expressed in adult head. FBgn0039638 UniProtKB "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules (PubMed:19836241). (UniProtKB:Q9VAP2)" FBgn0005596 FlyBase Gene Snapshot yemanuclein (yem) is a maternally expressed gene essential in the oocyte for meiosis and in the zygote for male pronucleus chromatin assembly. yem encodes a chaperone of H3.3 histone variant in partnership with the protein encoded by Hira. It also interacts with components of the Cohesin and the synaptonemal complexes. FBgn0039634 Alliance "Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in encapsulation of foreign target. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic proventriculus; embryonic/larval nervous system; and ganglia. Human ortholog(s) of this gene implicated in Rafiq syndrome. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1)." FBgn0039626 UniProtKB "Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (UniProtKB:Q9VAQ7)" FBgn0039625 FlyBase Gene Snapshot "beta1,4-N-acetylgalactosaminyltransferase B (beta4GalNAcTB) encodes a Golgi glycosyltransferase that transfers N-acetylgalactosamine to N-acetylglucosamine residues of glycosphingolipids." FBgn0039664 Alliance Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be active in nucleus. Orthologous to human DTWD1 (DTW domain containing 1). FBgn0039666 FlyBase Gene Snapshot "Diedel (Diedel) encodes a small extracellular immunomodulatory cytokine, which down-regulates the immune deficiency pathway of host defense. Some insect DNA viruses encode proteins homologous to the product of Diedel." FBgn0039667 Alliance Involved in positive regulation of protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adult head; dorsal pharyngeal muscle cell; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and embryonic/larval visceral muscle cell. FBgn0039668 UniProtKB Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development. (UniProtKB:Q7KRW1) FBgn0039665 Alliance "Is expressed in several structures, including CNS glial cell; adult head; dorsal ectoderm; dorsal epidermis primordium; and embryonic central brain." FBgn0040623 UniProtKB Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity). (Microbial infection) Plays an important role in infection by flaviviruses such as West Nile virus and Dengue virus type 2. (UniProtKB:Q9VAL0) FBgn0039663 Alliance Predicted to be active in nucleus. Is expressed in organism. Orthologous to human C2orf42 (chromosome 2 open reading frame 42). FBgn0015622 FlyBase Gene Snapshot Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para. FBgn0039659 Alliance Predicted to enable mRNA binding activity. FBgn0039669 FlyBase Gene Snapshot "NADH dehydrogenase (ubiquinone) 20 kDa subunit-like (ND-20L) encodes a flavoprotein and iron-sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. It is a component of the mitochondrial electron transport complex I, which is part of the oxidative phosphorylation pathway. It may have a role in regulating aggression behavior." FBgn0000492 FlyBase Gene Snapshot "Drop (Dr) encodes a homeodomain transcription factor involved in patterning of the neuroectoderm and wing disc, specification of myoblasts and neuroblasts, proper development of muscle, neuronal and glial cells, male genital disc, and regulation of glucose metabolism." FBgn0039674 Alliance "Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; phosphate ion transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11)." FBgn0039677 Alliance Predicted to enable ligand-gated sodium channel activity. Involved in detection of chemical stimulus involved in sensory perception of pain and regulation of terminal button organization. Part of sodium channel complex. FBgn0039678 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q9VAJ4) FBgn0039679 FlyBase Gene Snapshot "pickpocket 19 (ppk19) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family protein. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. In the adult stage it functions in salt taste likely through its expression in the chemical-sensing epithelia in the leg segment and wing blade." FBgn0039680 FlyBase Gene Snapshot "CAP-D2 condensin subunit (Cap-D2) encodes a component of the conserved condensin I complex, together with the products of Cap-G, barr, SMC2 and glu. Condensin I associates with mitotic chromatin and plays a crucial role in shaping mitotic chromosomes and in their faithful segregation during anaphase." FBgn0013972 FlyBase Gene Snapshot Guanylyl cyclase alpha-subunit at 99B (Gycalpha99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. FBgn0039683 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic brain; embryonic esophagus; embryonic optic lobe primordium; and embryonic pars intercerebralis. Orthologous to several human genes including DMRTA2 (DMRT like family A2)." FBgn0039684 FlyBase Gene Snapshot Odorant-binding protein 99d (Obp99d) encodes a small protein involved in smell perception. FBgn0024841 Alliance Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Is expressed in organism. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to several human genes including PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1). FBgn0039688 FlyBase Gene Snapshot Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Delta. FBgn0039687 Alliance "Predicted to enable histone H2A acetyltransferase activity; histone H4 acetyltransferase activity; and peptide-serine-alpha-N-acetyltransferase activity. Predicted to be active in nucleus. Is expressed in dorsal ectoderm anlage; mesoderm anlage; organism; and ventral ectoderm anlage. Orthologous to human NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit)." FBgn0039685 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q9VAI6) FBgn0039682 Alliance Predicted to enable odorant binding activity. Involved in response to fungus. Predicted to be located in extracellular region. Is expressed in adult head; adult heart; amnioserosa; embryonic/larval fat body; and yolk nucleus. FBgn0039681 Alliance Predicted to enable alkenylglycerophosphocholine hydrolase activity. Predicted to be active in membrane. Is expressed in adult head. Orthologous to several human genes including TMEM86A (transmembrane protein 86A). FBgn0025457 FlyBase Gene Snapshot "Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C." FBgn0039673 Alliance Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in axonemal dynein complex assembly and protein polyubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DAW1 (dynein assembly factor with WD repeats 1). FBgn0039670 Alliance Is expressed in embryonic/larval posterior spiracle; gut section; hindgut proper primordium; and larval ventral nerve cord. FBgn0039689 UniProtKB Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (UniProtKB:Q9VAI1) FBgn0039690 FlyBase Gene Snapshot "Glucosamine-phosphate N-acetyltransferase (Gnpnat) encodes an enzyme that catalyzes the transfer of the acetyl group of acetyl-CoA to D-glucosamine 6-phosphate to form N-acetyl-D-glucosamine 6-phosphate. It is involved in the biosynthesis of UDP-N-acetylglucosamine, a precursor for chitin biosynthesis and protein glycosylation." FBgn0039691 UniProtKB "Catalytic component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (By similarity). Mediates the snRNAs 3' cleavage (By similarity). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q9VAH9)" FBgn0019972 FlyBase Gene Snapshot "Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1." FBgn0039698 Alliance "Predicted to enable 3'(2'),5'-bisphosphate nucleotidase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Is expressed in adult head. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1)." FBgn0000247 FlyBase Gene Snapshot claret (ca) encodes a protein that is required for wild-type eye color. ca mutant flies show a wine-red eye color. FBgn0039704 Alliance "Involved in apical constriction and regulation of embryonic cell shape. Predicted to be located in membrane. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; anal pad primordium; epithelium; and gut section." FBgn0039707 FlyBase Gene Snapshot "Protamine-like 99C (Prtl99C) encodes a sperm chromatin-associated protein that is essential for male fertility. It acts additively together with the products of Mst77F, ProtA and ProtB to compact the paternal chromatin." FBgn0039709 FlyBase Gene Snapshot "Cadherin 99C (Cad99C) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication. Its roles include microvillus morphogenesis, tube elongation, endosome formation and immunity." FBgn0051038 Alliance "Is expressed in several structures, including anterior endoderm anlage; dorsal pharyngeal muscle primordium; embryonic anal pad; gut section; and visceral muscle primordium. Orthologous to human FAM89A (family with sequence similarity 89 member A)." FBgn0039719 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. FBgn0051036 Alliance "Colocalizes with cilium. Is expressed in several structures, including gut section; sense organ; sensory cluster; sensory nervous system primordium; and sensory neurons." FBgn0003357 UniProtKB Major function may be to aid in digestion. (UniProtKB:C0HKF8) | Major function may be to aid in digestion. (UniProtKB:C0HKF7) FBgn0039723 Alliance Is expressed in adult head; embryonic central brain neurons; and embryonic stomatogastric nervous system. FBgn0039727 Alliance Predicted to be involved in protein targeting to vacuole. Predicted to be extrinsic component of membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Cohen syndrome. Orthologous to human VPS13B (vacuolar protein sorting 13 homolog B). FBgn0004622 UniProtKB Receptor for tachykinin-like peptides. (UniProtKB:P30975) FBgn0039726 FlyBase Gene Snapshot eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer. FBgn0051040 UniProtKB Required for normal Golgi function. (UniProtKB:Q9VAD6) FBgn0051202 Alliance "Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1); MAN1A2 (mannosidase alpha class 1A member 2); and MAN1C1 (mannosidase alpha class 1C member 1)." FBgn0003358 UniProtKB Its major function may be to aid in digestion. (UniProtKB:P17207) FBgn0003356 UniProtKB Major function may be to aid in digestion. (UniProtKB:C0HKF8) | Major function may be to aid in digestion. (UniProtKB:C0HKF7) FBgn0003861 FlyBase Gene Snapshot transient receptor potential (trp) encodes a non-selective plasma membrane cation channel with high Ca[2+] permeability. It is highly eye-enriched and contributes to the electrical response to light in photoreceptors. FBgn0039722 FlyBase Gene Snapshot Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. FBgn0039712 Alliance Predicted to enable DNA binding activity. Is expressed in organism. FBgn0039710 Alliance Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NSL complex. Is expressed in organism. Orthologous to human KANSL2 (KAT8 regulatory NSL complex subunit 2). FBgn0039705 FlyBase Gene Snapshot "Autophagy-related 16 (Atg16) encodes a protein that forms an E3-like protein complex. This complex contributes to the the covalent binding of the lipid phosphatidylethanolamine to the product of Atg8a, a key autophagy protein involved in autophagosome biogenesis. The product of Atg16 is involved in autophagosome biogenesis, maintenance of proper neuromuscular function, lifespan, ethanol sedation, and enteroendocrine cell function in the intestine." FBgn0039703 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in organism. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0039702 FlyBase Gene Snapshot "Vacuolar protein sorting 16B (Vps16B) encodes a protein that, together with its binding partner encoded by Vps33B, forms a distinct complex necessary for fusions between phagosomes and lysosomes." FBgn0002924 FlyBase Gene Snapshot non-claret disjunctional (ncd) encodes a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos. FBgn0039697 Alliance "Predicted to enable electron transfer activity. Predicted to be involved in amino acid catabolic process and fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFB (electron transfer flavoprotein subunit beta)." FBgn0039696 Alliance Involved in regulation of circadian rhythm. Located in cytosol. Is expressed in adult brain cell body rind. Human ortholog(s) of this gene implicated in ACTH-independent macronodular adrenal hyperplasia 2. Orthologous to human ARMC5 (armadillo repeat containing 5). FBgn0039694 Alliance Predicted to enable protein serine/threonine phosphatase activity. Involved in regulation of ubiquinone biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). FBgn0020235 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. (UniProtKB:O01666)" FBgn0027518 FlyBase Gene Snapshot WD repeat domain 24 (Wdr24) encodes a component of the GATOR2 complex that promotes activation of the Crtc product and anabolic metabolism. It localizes to lysosomes and autolysosomes and regulates lysosome function independent of the activity of the Crtc product. FBgn0027583 UniProtKB Putative oxidoreductase. (UniProtKB:Q9Y140) FBgn0039728 Alliance Is expressed in spermatozoon. FBgn0039731 FlyBase Gene Snapshot "Spindle assembly abnormal 6 (Sas-6) encodes a centriole protein that is essential for centriole assembly. It can homo-oligomerise to form a 9-fold symmetric ""cartwheel"" structure that plays an important part in setting the 9-fold symmetry of the assembling centriole." FBgn0039733 Alliance "Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; cuboidal/columnar epithelium; embryonic central brain neurons; embryonic/larval nervous system; and ganglia." FBgn0039734 FlyBase Gene Snapshot "Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway." FBgn0016685 UniProtKB Binds to core histones and functions in the ATP-facilitated assembly of approximately regularly spaced nucleosomal arrays. May participate in parallel with other histone-binding proteins such as NAP-1. (UniProtKB:Q27415) FBgn0026597 FlyBase Gene Snapshot "Axin (Axn) encodes the key scaffolding protein for the canonical Wnt signalling pathway. In the absence of signal, it targets the product of arm for proteolysis inhibiting Wnt signalling. In the presence of signal, it forms a part of the membrane activation complex, disrupting the product of arm degradation. This pathway play roles in cell proliferation (imaginal disc), differentiation (embryonic patterning), death and stemness." FBgn0003511 UniProtKB Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'. (UniProtKB:P07665) FBgn0003510 UniProtKB "Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. (UniProtKB:P07666)" FBgn0003512 UniProtKB Transcriptional activator that controls bicoid gene expression during oogenesis. Found in transcriptionally active cells. Binds to specific sites on polytene chromosomes of third instar larvae. Binds to the consensus DNA sequence 5'-YTAGAGATGGRAA-3'. (UniProtKB:P07664) FBgn0039741 Alliance "Predicted to enable NAD transmembrane transporter activity. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval hemocyte; embryonic/larval midgut; embryonic/larval midgut primordium; and procrystal cell. Orthologous to human SLC25A51 (solute carrier family 25 member 51) and SLC25A52 (solute carrier family 25 member 52)." FBgn0039743 Alliance Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to several human genes including HDGFL2 (HDGF like 2) and PSIP1 (PC4 and SRSF1 interacting protein 1). FBgn0039744 Alliance Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex. Predicted to be active in nucleolus. Orthologous to human RPP14 (ribonuclease P/MRP subunit p14). FBgn0260468 Alliance Predicted to enable protein-disulfide reductase activity. Predicted to be involved in protein import into mitochondrial intermembrane space and protein maturation by protein folding. Predicted to be active in mitochondrial intermembrane space. Is expressed in adult head. Orthologous to human CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4). FBgn0039748 Alliance Predicted to enable signaling adaptor activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and intracellular signal transduction. Predicted to be located in cytosol. Is expressed in embryonic/larval tracheal dorsal trunk and organism. FBgn0039756 Alliance "Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic dorsal epidermis; embryonic/larval somatic muscle cell; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5)." FBgn0039755 Alliance Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). FBgn0039754 Alliance "Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5)." FBgn0039751 Alliance Predicted to enable pyridoxal phosphate binding activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). FBgn0051028 Alliance "Predicted to enable metal ion binding activity. Predicted to be involved in superoxide metabolic process. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; and gut section." FBgn0051030 Alliance Enables ATPase regulator activity. Predicted to be involved in regulation of cellular pH. Located in presynaptic membrane. Part of proton-transporting V-type ATPase complex. Is expressed in adult head; central brain primordium; embryonic antennal sense organ; ganglia; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). FBgn0039749 Alliance Predicted to be involved in mitochondrial protein catabolic process and mitophagy by internal vacuole formation. Predicted to be active in mitochondrial outer membrane. Is expressed in spermatozoon. FBgn0039747 FlyBase Gene Snapshot Adenosine receptor (AdoR) encodes a protein belongsING to the G protein-coupled receptor family (Class A) that functions via cAMP and PKA activation. It is involved in response to metabolic stress and neuromodulation. FBgn0051029 Alliance Is expressed in spermatozoon. FBgn0051025 Alliance Enables protein phosphatase 1 binding activity. Is expressed in spermatozoon. FBgn0003479 FlyBase Gene Snapshot "spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand." FBgn0039742 Alliance Predicted to enable protein tyrosine/serine/threonine phosphatase activity. Is expressed in organism. Orthologous to several human genes including DUSP14 (dual specificity phosphatase 14). FBgn0002626 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome and nucleolus. Colocalizes with nuclear chromosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPL32 (ribosomal protein L32). FBgn0001280 UniProtKB JanA and janB regulate somatic sex differentiation. (UniProtKB:P20348) FBgn0001281 UniProtKB JanA and janB regulate somatic sex differentiation. (UniProtKB:P20349) FBgn0041102 Alliance Predicted to enable protein histidine phosphatase activity. Located in nucleus. Is expressed in adult head and spermatozoon. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). FBgn0039740 FlyBase Gene Snapshot Zinc-finger protein interacting with CP190 (ZIPIC) encodes a promoter-binding transcription factor that displays architectural and insulator functions. FBgn0039739 Alliance Predicted to be a structural constituent of ribosome. Involved in wing disc development. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). FBgn0039737 Alliance "Predicted to enable acetate CoA-transferase activity. Predicted to be involved in acetate metabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; epithelium; and gut section." FBgn0039735 FlyBase Gene Snapshot Nucleophosmin (Nph) encodes a histone binding protein involved in chromatin remodeling and sperm chromatin decondensation. FBgn0039732 Alliance Predicted to be part of U2-type spliceosomal complex and post-mRNA release spliceosomal complex. Is expressed in wing hinge primordium and wing pouch. Orthologous to human CCDC12 (coiled-coil domain containing 12). FBgn0039730 Alliance Predicted to enable mRNA binding activity. Is expressed in adult head and organism. FBgn0000032 Alliance "Enables acid phosphatase activity and protein homodimerization activity. Predicted to be located in extracellular exosome and nucleus. Is expressed in adult heart and germline cell. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to several human genes including ACP2 (acid phosphatase 2, lysosomal) and ACP4 (acid phosphatase 4)." FBgn0000279 FlyBase Gene Snapshot Cecropin C (CecC) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is strongly expressed at the pupal stage. FBgn0010113 FlyBase Gene Snapshot headcase (heca) encodes two proteins by translational readthrough of a single mRNA. It is an esg target in the trachea and presumably also in imaginal tissues. The readthrough product is necessary for heca function in the trachea. FBgn0015221 FlyBase Gene Snapshot "Ferritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis." FBgn0039765 FlyBase Gene Snapshot "mitochondrial ribosomal protein S18C (mRpS18C) encodes a component of the small subunit of mitochondrial ribosomes, which translate mRNAs encoded by the mitochondrial genome." FBgn0039768 Alliance Predicted to enable acid sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in adult head and organism. FBgn0039767 Alliance Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human UBOX5 (U-box domain containing 5). FBgn0015222 FlyBase Gene Snapshot "Ferritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis." FBgn0051023 Alliance Predicted to enable CUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0051383 Alliance Predicted to enable CUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0039759 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0039758 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0039769 Alliance Predicted to enable acid sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in adult head. FBgn0039774 FlyBase Gene Snapshot Ceramidase (CDase) encodes a protein that has a cell non-autonomous function in maintaining membrane homeostasis. CDase targeted over-expression suppresses retinal degeneration in certain photoreceptor degeneration mutants. FBgn0039776 Alliance "Predicted to enable procollagen-proline 4-dioxygenase activity. Located in endomembrane system. Is expressed in several structures, including adult brain cell body rind; adult head; dorsal epidermis primordium; embryonic dorsal epidermis; and follicle cell. Human ortholog(s) of this gene implicated in myopia. Orthologous to several human genes including P4HA1 (prolyl 4-hydroxylase subunit alpha 1)." FBgn0260440 FlyBase Gene Snapshot "sanpodo (spdo) encodes a four-pass transmembrane domain containing protein that interacts with both the product of numb and the Notch signaling pathway to enable precursor cells to divide asymmetrically to produce daughter cells of distinct fates. Its roles include cell fate specification in the nervous system, mesoderm, and endoderm." FBgn0039778 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0039779 FlyBase Gene Snapshot prolyl-4-hydroxylase-alpha SG2 (PH4alphaSG2) encodes an enzyme that hydroxylates prolines in collagens and other secreted matrix proteins. It is required for proper salivary gland development. FBgn0039782 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0039784 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. FBgn0082582 FlyBase Gene Snapshot tropomodulin (tmod) encodes an actin/tropomyosin-associated protein involved in Notch signaling regulation. FBgn0039787 Alliance Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human SLC26A11 (solute carrier family 26 member 11). FBgn0051019 Alliance Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Orthologous to human AGBL4 (AGBL carboxypeptidase 4). FBgn0051021 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0051017 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0051015 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in embryonic proventriculus and proventriculus primordium. FBgn0051013 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0039790 Alliance "Predicted to enable ATP binding activity and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2)." FBgn0039789 Alliance "Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Bolwig organ; adult head; embryonic dorsal apodeme; embryonic head epidermis; and epidermis. Orthologous to human SLC26A11 (solute carrier family 26 member 11)." FBgn0039788 Alliance "Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in adult heart and organism. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5)." FBgn0027654 Alliance Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adult head and embryonic/larval corpus allatum. Orthologous to human DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12). FBgn0051524 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). FBgn0039783 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in cell migration and sexual reproduction. Predicted to be located in extracellular space. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Used to study prostate cancer. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). FBgn0051014 FlyBase Gene Snapshot prolyl-4-hydroxylase-alpha SG1 (PH4alphaSG1) encodes an enzyme that hydroxylates prolines in collagens and other secreted matrix proteins. It is required for proper salivary gland development. FBgn0051371 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. FBgn0039780 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). FBgn0026190 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. FBgn0039777 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0039773 Alliance Predicted to enable K63-linked deubiquitinase activity. Predicted to be involved in protein K63-linked deubiquitination. Predicted to be active in endosome and membrane. Is expressed in adult head and presumptive embryonic/larval central nervous system. Orthologous to human STAMBP (STAM binding protein) and STAMBPL1 (STAM binding protein like 1). FBgn0028646 FlyBase Gene Snapshot mitochondrial aspartate/glutamate carrier (Aralar) encodes a transmembrane transporter that catalyzes the calcium-dependent exchange of cytosolic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. It is involved in the malate-aspartate shuttle and gluconeogenesis. FBgn0039771 Alliance Involved in cuticle development. Located in endosome membrane. FBgn0039770 Alliance Predicted to enable corticotropin-releasing hormone binding activity. Predicted to be involved in hormone metabolic process; hormone-mediated signaling pathway; and negative regulation of corticotropin secretion. Predicted to be active in extracellular space. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). FBgn0039795 Alliance "Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1)." FBgn0039797 Alliance Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). FBgn0039799 Alliance Predicted to enable (d)CMP kinase activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Orthologous to human AK8 (adenylate kinase 8). FBgn0039802 UniProtKB "Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251). (UniProtKB:Q9VA37)" FBgn0027598 FlyBase Gene Snapshot "CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis." FBgn0039804 Alliance Is expressed in Bolwig organ; dorsal head epidermis; embryonic antennal sense organ; embryonic head epidermis; and embryonic head sensory system. FBgn0039805 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult fat body; adult head; and embryonic head epidermis. FBgn0015032 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VA27) FBgn0000416 FlyBase Gene Snapshot "Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration." FBgn0039809 Alliance Predicted to be involved in cilium movement and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be active in cilium. Is expressed in spermatogonium and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5). FBgn0039808 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus." FBgn0011739 FlyBase Gene Snapshot warts (wts) encodes a tumor suppressor kinase in the Hippo pathway involved in the control of tissue growth. It also plays a post-mitotic role in R8 photoreceptor cells where it antagonizes the product of melt to control the bistable choice of Rhodospin expression. FBgn0039801 FlyBase Gene Snapshot "Niemann-Pick type C-2h (Npc2h) encodes a protein involved in immune signaling via interaction with lipopolysaccharides, lipid A, peptidoglycan and lipoteichoic acid." FBgn0039800 Alliance Predicted to enable sterol binding activity. Involved in mesoderm development. Located in extracellular region. Is expressed in adult head; adult heart; head mesoderm; plasmatocyte primordium; and visceral mesoderm derivative. FBgn0039798 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular region. FBgn0000274 Alliance Predicted to enable cAMP-dependent protein kinase activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to be part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Predicted to be active in cytosol and nucleus. FBgn0039796 Alliance Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in protein kinase A signaling. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. FBgn0010015 UniProtKB "Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). This subunit may have a role in the calmodulin activation of calcineurin (Probable). At the periactive zone of synaptic boutons at neuromuscular junctions, promotes formation of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) microdomains and subsequent synaptic vesicle reformation during Ca(2+) channel-dependent activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (PubMed:33300871). This function may be fwe-dependent (PubMed:33300871). (UniProtKB:P48456)" FBgn0016123 UniProtKB Important role in neural and renal epithelial function. (UniProtKB:Q24238) FBgn0024288 FlyBase Gene Snapshot "Sox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad." FBgn0039821 Alliance Predicted to enable G protein-coupled receptor activity and mechanoreceptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in plasma membrane. Is expressed in adult head. Orthologous to human ADGRG7 (adhesion G protein-coupled receptor G7). FBgn0039818 Alliance Predicted to enable G protein-coupled receptor activity and mechanoreceptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in plasma membrane. Is expressed in adult head and organism. Orthologous to human ADGRG7 (adhesion G protein-coupled receptor G7). FBgn0039816 Alliance Is expressed in embryonic brain; larval ventral nerve cord; and lateral cord neurons. FBgn0002413 FlyBase Gene Snapshot "discs overgrown (dco) encodes a Ser/Thr protein kinase that functions in the circadian rhythm pathway to phosphorylate and bind with circadian target proteins such as the product of per. It also contributes to Hedgehog and Wnt pathways, cell death, neurodegeneration, hyperplasia and planar cell polarity." FBgn0010808 FlyBase Gene Snapshot "Coiled-coil-helix-coiled-coil-helix domain containing 3 (Chchd3) encodes a mitochondrial inner membrane protein that is required for mitochondrial fusion. Loss of Chchd3 leads to inactivation of Hippo activity, decreased tissue growth, cell proliferation defects, oxidative stress and JNK pathway activation." FBgn0004573 FlyBase Gene Snapshot "5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT7 is involved in olfactory learning and memory, and courtship behaviors." FBgn0051008 Alliance Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in mitochondrion organization and positive regulation of transcription by RNA polymerase II. Predicted to be active in mitochondrion and nucleus. FBgn0062411 FlyBase Gene Snapshot "Copper transporter 1C (Ctr1C) is expressed in the male gonad. The autosomal gene seems to have originated as a retrogene copy of the X-linked Ctr1A, thus maintaining copper delivery during male spermatogenesis when the X chromosome is inactive." FBgn0013973 FlyBase Gene Snapshot Guanylyl cyclase beta-subunit at 100B (Gycbeta100B) encodes an enzyme that synthesizes cyclic GMP and is activated by nitric oxide. FBgn0004389 FlyBase Gene Snapshot bottleneck (bnk) encodes a protein involved in actin filament bundle organization. It controls the structural organization of the actomyosin network and times basal closure of the cells during cellularization. FBgn0039827 UniProtKB "2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). (UniProtKB:Q9VA02)" FBgn0039828 UniProtKB Required for the processing of the 27S pre-rRNA. (UniProtKB:Q9V9Z9) FBgn0039831 Alliance Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; embryonic/larval nervous system; larval ventral nerve cord; and organism. Orthologous to human JAZF1 (JAZF zinc finger 1). FBgn0039835 UniProtKB Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria. (UniProtKB:Q9V9Z1) FBgn0039838 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Orthologous to human CA6 (carbonic anhydrase 6). FBgn0040628 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Orthologous to human CA6 (carbonic anhydrase 6). FBgn0040629 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in testis. Orthologous to human CA6 (carbonic anhydrase 6). FBgn0039839 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0039840 FlyBase Gene Snapshot pH-sensitive chloride channel 2 (pHCl-2) encodes a channel involved in chloride transmembrane transport and renal water transport regulation. FBgn0039836 Alliance Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). FBgn0051005 FlyBase Gene Snapshot "qless (qless) encodes a protein involved in the synthesis of the isoprenoid side chain of Coenzyme Q, a lipid component of the mitochondrial electron transport chain." FBgn0039833 Alliance Predicted to be involved in positive regulation of cytokinesis. Predicted to be active in centrosome and spindle pole. FBgn0039830 Alliance "Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Used to study early-onset dystonia and/or spastic paraplegia and mitochondrial complex V (ATP synthase) deficiency. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia; renal cell carcinoma; and urinary bladder cancer. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1); ATP5MC2 (ATP synthase membrane subunit c locus 2); and ATP5MC3 (ATP synthase membrane subunit c locus 3)." FBgn0046696 Alliance Enables ribonuclease P activity. Involved in tRNA 5'-end processing. Part of ribonuclease P complex. FBgn0039829 Alliance Predicted to enable nucleic acid binding activity. Predicted to be active in nucleolus. Is expressed in embryonic/larval midgut and organism. Orthologous to human GPATCH4 (G-patch domain containing 4 (gene/pseudogene)). FBgn0061476 FlyBase Gene Snapshot Zwilch (Zwilch) encodes a subunit of the RZZ complex located at the kinetochores of chromosomes. The RZZ complex plays an essential role in the spindle assembly checkpoint that ensures proper connections between chromosomes and the mitotic spindle. FBgn0051004 UniProtKB "Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction (PubMed:22854041, PubMed:26848177). Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium (PubMed:22854041). Required for maintaining the three-layered structure of the proventriculus (PubMed:22854041). (UniProtKB:Q0KHY3)" FBgn0046332 FlyBase Gene Snapshot "gasket (gskt) is a retro-transposed glycogen synthase kinase 3 gene, derived from sgg, that is required for male fertility. Like many genes retroposed from the X chromosome, it is highly expressed in the testis." FBgn0039844 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Is expressed in adult abdomen; adult head; adult thorax; embryonic proventriculus; and wing disc. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to several human genes including SLC7A8 (solute carrier family 7 member 8). FBgn0019990 FlyBase Gene Snapshot "Gcn2 (Gcn2) encodes a kinase activated during amino acid starvation to phosphorylate the eIF2 subunit encoded by eIF2alpha. Gcn2 product plays roles in ageing, dpp signalling, dietary choice and response to infection." FBgn0039850 Alliance Predicted to be active in cytoplasm. Orthologous to several human genes including ISOC1 (isochorismatase domain containing 1). FBgn0039851 Alliance "Involved in apical constriction and regulation of embryonic cell shape. Predicted to be located in membrane. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic epipharynx; epithelium; and gut section." FBgn0039852 Alliance "Involved in apical constriction and regulation of embryonic cell shape. Predicted to be located in membrane. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic head sensory system; embryonic ventral epidermis; and gut section." FBgn0028968 FlyBase Gene Snapshot "Coat Protein (coatomer) gamma (gammaCOP) encodes a subunit of the coat complex of COPI vesicles, which transport cargo within the Golgi apparatus and from the Golgi apparatus to the endoplasmic reticulum. Its functions include membrane and protein trafficking in the secretory apparatus." FBgn0003268 FlyBase Gene Snapshot "rough deal (rod) encodes the major subunit of the Rod-Zw10-Zwilch (RZZ) complex. RZZ is an essential component of the outer kinetochore during mitosis. RZZ helps monitor and correct kinetochore-microtubule attachments during prometaphase, and consequently it regulates mitotic progression." FBgn0039854 Alliance Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). FBgn0039855 Alliance Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Predicted to be active in mitochondrion. Is expressed in spermatozoon. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). FBgn0039856 Alliance Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). FBgn0039858 FlyBase Gene Snapshot "Cyclin G (CycG) encodes a protein that belongs to the atypical cyclins. It interacts with diverse proteins such as the product of H, beta-subunits of PP2a, the 9-1-1 complex, cyclin-dependent kinases and Enhancer of Trithorax and Polycomb proteins. The product of CycG contributes to DNA repair, cell cycle regulation, growth and metabolism, epigenetic gene regulation and developmental stability." FBgn0039857 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit assembly. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPL6 (ribosomal protein L6). FBgn0043900 FlyBase Gene Snapshot "pygopus (pygo) encodes a key nuclear component of the Wnt signaling pathway. It facilitates the recruitment of the product of arm to Wnt-responsive genes by interacting with the transcription cofactor encoded by Chi. It also binds the product of lgs and the methylated tail of the product of His3. Together, they associate with the product of arm in a process that may function as a transition from gene silence to Wnt-induced transcription." FBgn0039849 UniProtKB Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (UniProtKB:Q9V9X4) FBgn0039848 FlyBase Gene Snapshot Lysyl oxidase-like 1 (Loxl1) encodes a protein-lysine 6-oxidase that might be involved in euchromatinization and gene regulation. FBgn0039846 FlyBase Gene Snapshot Polynucleotide phosphorylase (PNPase) encodes an enzyme involved in the regulation of mitochondrial mRNA stability. FBgn0051002 Alliance Predicted to enable UDP-glycosyltransferase activity. Located in endomembrane system. Is expressed in amnioserosa and yolk nucleus. Orthologous to human UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus). FBgn0039860 Alliance Enables DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism. FBgn0039861 FlyBase Gene Snapshot partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing. FBgn0039862 Alliance Enables neurotrophin binding activity. Involved in regulation of synaptic plasticity. Located in type I terminal bouton. Is expressed in adult head; embryonic/larval central nervous system; larval ventral nerve cord; and lineage NB3-1 primary motor neurons. FBgn0039863 UniProtKB Chromatin reader that recognizes specific histone signatures to regulate transcription (By similarity). Plays a role in neuronal development (PubMed:35916866). (UniProtKB:Q7KRS9) FBgn0003870 UniProtKB "Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk. (UniProtKB:P42282)" FBgn0039868 Alliance Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human NOP16 (NOP16 nucleolar protein). FBgn0000557 UniProtKB This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. (UniProtKB:P05303) FBgn0039869 Alliance Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be active in microtubule cytoskeleton. Is expressed in organism. Orthologous to human TBCA (tubulin folding cofactor A). FBgn0039870 Alliance Is expressed in organism. FBgn0022349 Alliance "Involved in long-term memory. Located in nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative." FBgn0039875 FlyBase Gene Snapshot septin interacting protein 3 (sip3) encodes a transmembrane protein in the endoplasmic reticulum (ER) membrane with ubiquitin ligase activity. It promotes the degradation of misfolded peptides by retro-translocating them from the ER lumen to the cytoplasm and sending them for proteasomal degradation via ubiquitylation. FBgn0005632 UniProtKB "Ubiquitin C-terminal hydrolase involved in development and the imd/NF-kappa-B (IMD) signaling cascade (PubMed:1295747, PubMed:23919485). Required for eye and embryo development, and plays a role in compound eye assembly and oogenesis respectively (PubMed:1295747). In the larval eye disks, cells outside the assembling facets require this protein for short-range cell interactions that prevent the mystery cells from becoming photoreceptors (PubMed:1295747). Also required for nuclear migration and cellularization in early embryogenesis and could play a role in pole cell determination, development or function (PubMed:1295747). Regulates the IMD signaling cascade at later stages of infection (around 6 hours post-infection) by inhibiting the expression of the antimicrobial peptides Dpt and Dro (PubMed:23919485). Acts by modulating the state of imd polyubiquitination and/or stability; a function which appears to be independent of its enzymatic activity (PubMed:23919485). In turn, imd enhances the polyubiquitination and stability of faf suggesting that they may form a regulatory feedback mechanism within the Imd pathway (PubMed:23919485). (UniProtKB:P55824)" FBgn0027620 FlyBase Gene Snapshot "ATP-dependent chromatin assembly factor large subunit (Acf) encodes a common subunit of two ATP-dependent nucleosome remodeling complexes: the ATP-dependent chromatin assembly and remodeling factor (ACF) and the chromatin accessibility complex. In these complexes the product of Acf interacts with the ATPase encoded by Iswi and modulates its nucleosome sliding activity, which affects the regularity of nucleosomal arrays and their precise spacing. The ACF complex has also been found to promote nucleosome assembly." FBgn0039879 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in sensory perception of taste. Predicted to be located in membrane. Is expressed in dorsal cibarial sense organ neurons; gustatory receptor neuron of the epiphysis; hypopharyngeal organ; labral sense organ neurons; and larval hypopharyngeal organ gustatory receptor neurons. FBgn0039881 Alliance Is expressed in organism. FBgn0039882 Alliance "Predicted to enable riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; amnioserosa; embryonic/larval crystal cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study Brown-Vialetto-Van Laere syndrome. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; Fazio-Londe disease; and riboflavin deficiency. Orthologous to several human genes including SLC52A3 (solute carrier family 52 member 3)." FBgn0039877 FlyBase Gene Snapshot "Methylcrotonoyl-CoA carboxylase 1 (Mccc1) encodes the biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase. It catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism." FBgn0039876 Alliance Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Is expressed in organism. Orthologous to human JKAMP (JNK1/MAPK8 associated membrane protein). FBgn0003065 Alliance "Predicted to be a structural constituent of chitin-based cuticle. Predicted to be located in chitin-based extracellular matrix. Is expressed in several structures, including adult head; dorsal head epidermis; embryonic epipharynx; embryonic head epidermis; and gut section." FBgn0039873 FlyBase Gene Snapshot "Sodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium." FBgn0017448 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0039872 FlyBase Gene Snapshot salty dog (salt) encodes a sodium/solute symporter in the SLC5 family involved in response to salt stress. FBgn0000150 FlyBase Gene Snapshot "abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration." FBgn0039867 Alliance Predicted to be involved in mRNA 3'-end processing. Located in nucleoplasm. Part of mRNA cleavage stimulating factor complex. Is expressed in organism. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). FBgn0039864 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0039859 UniProtKB "N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin (PubMed:33479178). Required for microtubule stability and inhibition of JNK signaling to promote cell survival during development, possibly acting independently of its N-acetyltransferase activity (PubMed:33479178). Necessary for the stabilization of spindle microtubules and for mitosis progression (PubMed:33479178). Regulates microtubule stability by inhibiting Spastin-mediated depolymerization and promoting Eb1-mediated polymerization (PubMed:33479178). (UniProtKB:Q9V9V9)" FBgn0039883 UniProtKB GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). Promotes the anchoring of Liprin-alpha clusters at synapses (PubMed:22864612). Recruits and keeps Nrx-1 levels high in active zones in the presynapse opposite the postsynaptic region (PubMed:22864612). (UniProtKB:Q9V9S7) FBgn0039886 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult head; embryonic/larval midgut primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4)." FBgn0039887 Alliance Predicted to be involved in negative regulation of translation. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. FBgn0002780 FlyBase Gene Snapshot "modulo (mod) encodes a nucleolar protein that is required for growth of proliferative cells through its association with the proto-oncogene Myc. The mod protein is essential for transcription of spermatid-differentiation genes and for high expression of meiotic arrest genes. The product of mod is phosphorylated, which in turn regulates its localization." FBgn0002645 FlyBase Gene Snapshot "Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase." FBgn0040206 FlyBase Gene Snapshot "kurtz (krz) encodes a beta-arrestin (non-visual arrestin) involved in the desensitization and endocytic internalization of G protein coupled receptors, thus downregulating their activity. It also controls other signaling pathways, including Notch, receptor tyrosine kinase, Hedgehog, and Toll. It is required maternally for normal embryonic patterning and zygotically for larval viability." FBgn0011224 FlyBase Gene Snapshot hephaestus (heph) encodes a nucleo-cytoplasmic shuttling protein that regulates osk mRNA translation. It is involved in spermatid individualization and Notch signalling regulation. FBgn0032956 FlyBase Gene Snapshot Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche. FBgn0051619 FlyBase Gene Snapshot no long nerve cord (nolo) encodes a protein involved in ventral cord development. FBgn0032961 Alliance "Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including AHSA1 (activator of HSP90 ATPase activity 1)." FBgn0003866 UniProtKB "Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk. Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity. Necessary, in combination with Scr, for the formation of the prothoracic segment. Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes. Required for proper development of proximal leg segments. Has differential functions along the dorso-ventral axs of the antennal and leg disks. May play a role in wing hinge development. Possible involvement in chromatin structure for modulation of transcription. Binds DNA and can act as both a transcriptional repressor and activator. Positively regulates its own expression as well as that of Dll. Negatively regulates the expression of mod. Required for Wg-mediated transcriptional repression of Ubx in the midgut. Also represses transcription of lab in the midgut and is necessary for the proper formation of anterior and central midgut structures. Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg. (UniProtKB:P22265)" FBgn0051612 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in gonad; head mesoderm; and organism." FBgn0032964 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0000559 UniProtKB "Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (UniProtKB:P13060)" FBgn0032966 Alliance Predicted to enable nucleic acid binding activity. FBgn0032967 Alliance Is expressed in adult head. FBgn0051702 Alliance Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Predicted to be part of Cdc73/Paf1 complex. Is expressed in spermatid and spermatocyte. FBgn0032971 FlyBase Gene Snapshot tiny tim 3 (ttm3) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. FBgn0032973 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0025674 FlyBase Gene Snapshot "Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by Polr2A) and contributes to pre-mRNA processing, transcription and chromatin structure." FBgn0032972 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. FBgn0051703 Alliance Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Located in nucleus. Is expressed in spermatid and spermatocyte. FBgn0051601 Alliance Predicted to enable metal ion binding activity. FBgn0032969 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Orthologous to human PREP (prolyl endopeptidase). FBgn0032981 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0032986 UniProtKB Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:34950192). May deliver one or more Fe-S clusters to complex I subunits (By similarity). Alleviates pausing in mitochondrial DNA (mtDNA) replication at slow zone 2 (PubMed:34950192). May be involved in mtDNA-helicase-mediated mtDNA unwinding and replication by transferring iron-sulfur clusters (PubMed:34950192). (UniProtKB:Q9V9M8) FBgn0032988 Alliance "Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor activity. Involved in female germ-line stem cell population maintenance and nucleolar large rRNA transcription by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor)." FBgn0039972 Interactive Fly post-transcriptional effector domain that recruits CCR4-NOT deadenylase complex to shorten target mRNA poly-A tails and suppress their translation - ensures proper oocyte maturation by regulating nanos expression - transition from meiosis I to II is compromised mutant oocytes FBgn0032987 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in hypotrichosis 12. Orthologous to human RPL21 (ribosomal protein L21). FBgn0032979 FlyBase Gene Snapshot Chromatin-linked adaptor for MSL proteins (Clamp) encodes a zinc finger protein that is required to recruit the dosage compensation complex. It is essential in both males and females. It also functions outside of the dosage compensation pathway. FBgn0033047 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Fanconi syndrome; brain disease (multiple); carbohydrate metabolic disorder (multiple); myelomeningocele; and obesity. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A2 (solute carrier family 2 member 2); and SLC2A4 (solute carrier family 2 member 4). FBgn0033050 UniProtKB "Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). (UniProtKB:Q7KRR5)" FBgn0033055 FlyBase Gene Snapshot "Tubulin-binding cofactor E (Tbce) encodes one of the five tubulin chaperones. It facilitates the folding of alpha-tubulin, a subunit of alpha-beta tubulin heterodimers." FBgn0033058 UniProtKB Receptor for the neuropeptide CCHamide-2. (UniProtKB:Q4V622) FBgn0033060 Alliance Predicted to enable RNA binding activity and pseudouridine synthase activity. Predicted to be involved in RNA processing and pseudouridine synthesis. Orthologous to human TRUB2 (TruB pseudouridine synthase family member 2). FBgn0011958 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011957 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011932 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011931 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011887 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011880 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011956 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050316 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033065 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V9L1) FBgn0040502 Alliance Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CLEC4F (C-type lectin domain family 4 member F) and CD209 (CD209 molecule). FBgn0011934 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033069 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:A1Z6K7)" FBgn0050431 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in anlage in statu nascendi; central brain anlage in statu nascendi; embryonic/larval fat body; gonad; and yolk nucleus. FBgn0033074 UniProtKB Channel-forming protein essential for import of protein precursors into mitochondria. (UniProtKB:A1Z6L1) FBgn0021847 Alliance Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to several human genes including TTC7A (tetratricopeptide repeat domain 7A). FBgn0033072 Alliance Is expressed in organism. FBgn0011935 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033067 Alliance Predicted to enable carbohydrate binding activity. FBgn0011955 Alliance Predicted to enable CGU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011890 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0000546 FlyBase Gene Snapshot "Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis." FBgn0011888 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011889 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011933 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011938 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011891 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033062 FlyBase Gene Snapshot "Arsenic resistance protein 2 (Ars2) encodes a protein that binds the cap binding complex and plays roles in small RNA biogenesis. It facilitates miRNA processing from primary miRNAs to pre-miRNAs. In addition, it interacts with the product of Dcr-2, modulates its activity and is required for siRNA-mediated silencing and antiviral defense." FBgn0033061 Alliance Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. FBgn0033054 Alliance Is expressed in Bolwig organ and adult head. Orthologous to human TMEM164 (transmembrane protein 164). FBgn0033052 Alliance Predicted to enable sterol binding activity. Predicted to be involved in regulation of cholesterol biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be part of SREBP-SCAP complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human SCAP (SREBF chaperone). FBgn0033051 FlyBase Gene Snapshot "Ser/Thr-rich caspase (Strica) encodes a member of initiator caspases. It contributes, redundantly or cooperatively with the product of Dronc, to the apoptosis of selective larval neurons during metamorphosis and nurse cells during oogenesis, and competitive apoptosis of heterozygous mutant cells." FBgn0000043 UniProtKB "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (UniProtKB:P02572)" FBgn0033048 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in adult head; embryonic midgut chamber; embryonic/larval hindgut; embryonic/larval midgut; and embryonic/larval salivary gland. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4). FBgn0027507 Alliance Predicted to be located in cytoplasm. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human SCYL3 (SCY1 like pseudokinase 3). FBgn0033031 Alliance Is expressed in adult head; embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in craniotubular dysplasia Ikegawa type. Orthologous to human TMEM53 (transmembrane protein 53). FBgn0033032 Alliance "Involved in establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; and septate junction assembly. Located in membrane and pleated septate junction. Is expressed in several structures, including adult head; clypeo-labral primordium; epidermis; gland; and gut section." FBgn0022288 Alliance "Predicted to be involved in ribosome biogenesis. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1)." FBgn0033042 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0033043 FlyBase Gene Snapshot "Odorant receptor 42b (Or42b) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication." FBgn0033041 FlyBase Gene Snapshot Odorant receptor 42a (Or42a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0025693 Alliance "Predicted to enable zinc ion transmembrane transporter activity. Involved in detoxification of zinc ion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; clypeo-labral primordium; embryonic/larval midgut primordium; and gut section. Orthologous to human SLC30A4 (solute carrier family 30 member 4)." FBgn0033038 Alliance Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). FBgn0033033 UniProtKB "Inactive serine protease that plays a role in germ-band retraction and dorsal closure morphogenesis in embryogenesis; contributes to amnioserosa attachment and epithelial apico-basal polarity by regulating the localization of laminin LanA on the apical side of the amnioserosa epithelium (PubMed:20379222, PubMed:28628612). Contributes to epithelial morphogenesis probably by regulating the bsk/JNK pathway, as part of a negative-feedback loop, and by modulating the cross-talk between the Egfr, bsk/JNK and dpp signal transduction pathways (PubMed:20379222, PubMed:28628612). In larval development, antagonizes the morphogenetic movements controlled by the bsk/JNK signaling including male genitalia formation and thorax development (PubMed:20379222, PubMed:20530545, PubMed:25737837). (UniProtKB:Q7K5M0)" FBgn0033029 FlyBase Gene Snapshot CCR4-NOT transcription complex subunit 3 (Not3) encodes a poly(A)-specific ribonuclease involved in translation inhibition. FBgn0050438 Alliance "Predicted to enable UDP-glycosyltransferase activity. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and plasmatocyte primordium. Orthologous to several human genes including UGT1A8 (UDP glucuronosyltransferase family 1 member A8); UGT2A3 (UDP glucuronosyltransferase family 2 member A3); and UGT2B10 (UDP glucuronosyltransferase family 2 member B10)." FBgn0039970 Alliance Predicted to be active in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human FAM210B (family with sequence similarity 210 member B). FBgn0033028 Alliance Enables pyruvate secondary active transmembrane transporter activity. Involved in plasma membrane pyruvate transport. Located in plasma membrane. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including SLC16A5 (solute carrier family 16 member 5). FBgn0039969 FlyBase Gene Snapshot "Fission, mitochondrial 1 (Fis1) encodes a protein involved in mitochondrial dynamics, more specifically in the mitochondrial fission process." FBgn0033027 FlyBase Gene Snapshot "Troponin C isoform 4 (TpnC4) encodes a calcium-binding subunit in the troponin complex of flight muscle. Together with the other troponin subunits, it activates the muscle when it is stretched, leading to rapid oscillatory contractions." FBgn0050440 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic esophagus; epidermis; and germline cell. Orthologous to several human genes including MCF2L (MCF.2 cell line derived transforming sequence like)." FBgn0042085 FlyBase Gene Snapshot "Brahma associated protein 170kD (Bap170) encodes a multidomain protein that forms a trimeric complex together with the products of e(y)3 and polybromo, characterizing the Brahma chromatin remodeling complex PBAP." FBgn0029131 FlyBase Gene Snapshot Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. FBgn0050443 FlyBase Gene Snapshot Optix-binding protein (Opbp) encodes a Zn finger protein that can bind to the Six-family transcription factor encoded by Optix. FBgn0013732 FlyBase Gene Snapshot scrambled (sced) encodes a protein that localizes to the mitotic furrows and centrosomes. It is involved in actin reorganization during cell cycle and the assembly of pseudocleavage furrows in syncytial embryos. FBgn0033085 Alliance Orthologous to human C22orf39 (chromosome 22 open reading frame 39). FBgn0033086 UniProtKB Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). (UniProtKB:Q8MLL3) FBgn0033088 FlyBase Gene Snapshot Post-GPI attachment to proteins 3 (PGAP3) encodes a protein involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation. Lipid remodeling consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchored proteins. The product of PGAP3 is required for the phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling. FBgn0033092 Alliance Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP25 (ribonuclease P and MRP subunit p25) and RPP25L (ribonuclease P/MRP subunit p25 like). FBgn0033093 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). FBgn0014009 FlyBase Gene Snapshot Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes. FBgn0028579 Alliance "Predicted to enable channel activity. Predicted to be involved in transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval dorsal vessel; and male germline stem cell. Orthologous to human PHTF1 (putative homeodomain transcription factor 1) and PHTF2 (putative homeodomain transcription factor 2)." FBgn0042083 UniProtKB "Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival. (UniProtKB:Q9V9A7)" FBgn0027066 FlyBase Gene Snapshot "Eb1 (Eb1) encodes a microtubule end-binding protein that contributes to organization of the microtubule cytoskeleton. It is involved in chromosome segregation, wound healing and flight behavior." FBgn0033101 Alliance Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Is expressed in adult head; embryonic proventriculus; embryonic/larval midgut; and organism. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10) and AKR1B15 (aldo-keto reductase family 1 member B15). FBgn0033100 Alliance "Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; embryonic/larval muscle system; gut section; and mesoderm. Orthologous to human CISD3 (CDGSH iron sulfur domain 3)." FBgn0010482 Alliance "Is expressed in several structures, including adult fat body; adult head; adult heart; embryonic/larval cuticle; and spermatozoon." FBgn0033097 FlyBase Gene Snapshot Zinc/iron regulated transporter-related protein 42C.2 (Zip42C.2) encodes a protein involved in zinc detoxification and zinc transmembrane import. FBgn0033096 FlyBase Gene Snapshot Zinc/iron regulated transporter-related protein 42C.1 (Zip42C.1) encodes a plasma membrane resident zinc transporter belonging to the Zinc-Iron Permease family. It works together with the products of Zip42C.2 and Zip89B in dietary zinc absorption. FBgn0033095 Alliance "Enables monocarboxylic acid transmembrane transporter activity. Involved in export across plasma membrane and monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14)." FBgn0050446 Interactive Fly "catalyze directly the biosynthesis of the neuromodulator tyramine and indirectly the biosynthesis of octopamine - Tdc1 acts to synthesize tyramine, a potent diuretic factor in the Malpighian tubule - Tdc2 is required neurally for egg deposition U" FBgn0033089 Alliance Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Part of precatalytic spliceosome. Is expressed in adult head and spermatogonium. Orthologous to human PPIH (peptidylprolyl isomerase H). FBgn0033087 FlyBase Gene Snapshot "Heparan sulfate C5-epimerase (Hsepi) encodes a heparan sulfate modifying enzyme, which catalyzes the C5-epimerization of glucuronic acid, converting it to iduronic acid. Hsepi loss results in minor morphological defects and lifespan reduction." FBgn0033081 FlyBase Gene Snapshot "geminin (geminin) encodes a protein that interacts with the replication factor encoded by dup and regulates the Egfr pathway, DNA replication and chromosome ploidy." FBgn0033079 FlyBase Gene Snapshot Flavin-containing monooxygenase 2 (Fmo-2) encodes a monooxygenase involved in oxidation-reduction metabolism. FBgn0026761 FlyBase Gene Snapshot Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. FBgn0014028 FlyBase Gene Snapshot "Succinate dehydrogenase, subunit B (iron-sulfur) (SdhB) encodes the iron-sulfur cluster-containing subunit of the succinate dehydrogenase complex, which oxidizes succinate to fumarate and passes the electrons to quinones. The redox-active cofactors in this subunit are part of the electron transfer machinery in the complex." FBgn0033108 Alliance "Predicted to be active in cytosol. Is expressed in several structures, including embryonic posterior midline glial cell; embryonic/larval nervous system; ganglia; larval midline neurons; and ventral midline of embryo." FBgn0033113 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1). FBgn0028988 UniProtKB "Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. (UniProtKB:Q7YTY6)" FBgn0033115 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic foregut; embryonic head epidermis; and embryonic hypopharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to several human genes including SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2)." FBgn0050158 Alliance Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0033117 Alliance Predicted to enable 3'-5'-DNA exonuclease activity. Is expressed in organism. Orthologous to human TATDN1 (TatD DNase domain containing 1). FBgn0053348 FlyBase Gene Snapshot Chemosensory protein B 42a (CheB42a) encodes a member of a family of small secreted proteins associated with the chemosensory system and is involved in male courtship behavior. FBgn0053349 FlyBase Gene Snapshot pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection. FBgn0033122 Alliance Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Is expressed in organism. Orthologous to human GPS2 (G protein pathway suppressor 2). FBgn0029508 Alliance "Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; dorsal epidermis primordium; epithelium; and gut section. Orthologous to human TSPAN18 (tetraspanin 18) and TSPAN8 (tetraspanin 8)." FBgn0042086 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic midgut chamber and embryonic/larval midgut. FBgn0050160 Alliance Predicted to be located in membrane. Is expressed in embryonic midgut chamber and embryonic/larval midgut. FBgn0033124 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and embryonic midgut chamber. Orthologous to human TSPAN19 (tetraspanin 19). FBgn0029506 Alliance "Located in fusome. Is expressed in several structures, including CNS glial cell; adult head; epithelium; ganglia; and gut section. Orthologous to human TSPAN3 (tetraspanin 3)." FBgn0029507 Alliance "Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult CNS glial cell; adult head; adult heart; embryonic precursor of adult hindgut; and gut section. Orthologous to human TSPAN18 (tetraspanin 18) and TSPAN8 (tetraspanin 8)." FBgn0022960 FlyBase Gene Snapshot visceral mesodermal armadillo-repeats (vimar) encodes a protein involved in regulation of muscle homeostasis and rhabdomere development. Its expression in the visceral mesoderm is controlled by the product of bap. FBgn0050156 Alliance Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Predicted to be active in endoplasmic reticulum membrane. FBgn0033121 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V979) FBgn0050157 UniProtKB "Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. (UniProtKB:Q4V6M7)" FBgn0011895 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011894 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011893 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011892 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0066292 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg and wing. FBgn0066293 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg; third segment of antenna; and wing. FBgn0033112 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). FBgn0033110 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0040674 Alliance Involved in mesoderm development. FBgn0022224 Alliance "Predicted to enable protein tag activity. Predicted to be involved in mRNA splicing, via spliceosome and protein modification process. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBL5 (ubiquitin like 5)." FBgn0034511 Alliance Enables peptidoglycan binding activity. Involved in Toll receptor ligand protein activation cascade; antifungal innate immune response; and response to Gram-positive bacterium. Is active in extracellular space. FBgn0034512 Alliance Involved in antimicrobial humoral response. Located in extracellular space. Is expressed in adult head. FBgn0034513 Alliance Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Orthologous to human BLMH (bleomycin hydrolase). FBgn0034520 FlyBase Gene Snapshot lateral muscles scarcer (lms) encodes a homeodomain transcription factor that is an identity factor for lateral transverse muscles. FBgn0034527 Alliance Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in organism. Orthologous to human DCAF11 (DDB1 and CUL4 associated factor 11). FBgn0034529 UniProtKB Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. (UniProtKB:A1ZBW7) FBgn0034532 Alliance Predicted to be involved in regulation of cilium beat frequency. Predicted to be active in axoneme and ciliary basal body. Is expressed in spermatozoon. Orthologous to human CFAP206 (cilia and flagella associated protein 206). FBgn0034534 Alliance "Enables protein heterodimerization activity. Contributes to DNA-binding transcription factor activity. Involved in head development and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; central brain primordium; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to several human genes including MAFK (MAF bZIP transcription factor K)." FBgn0034535 Alliance Predicted to enable endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to be located in membrane. Predicted to be part of mitochondrial inner membrane peptidase complex. Is expressed in adult head. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). FBgn0034537 FlyBase Gene Snapshot DNA methyltransferase 1 associated protein 1 (DMAP1) encodes an evolutionarily conserved nuclear innate immune factor. It interacts with the NF-kappaB transcription factor encoded by Rel and modulates the activation of the immune deficiency pathway in complex with chromatin remodeling factors. Its roles also include larval-pupal development and cell survival. FBgn0034540 FlyBase Gene Snapshot Leucine-rich tendon-specific protein (Lrt) encodes a transmembrane protein expressed specifically in tendon cells. It binds to the product of robo1 and is required for proper patterning of the muscles. FBgn0050155 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034543 UniProtKB "Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex. (UniProtKB:Q9V968)" FBgn0034546 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in endosome and lysosome. Is expressed in adult head. Orthologous to human MARCHF3 (membrane associated ring-CH-type finger 3). FBgn0041240 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9V969)" FBgn0000615 UniProtKB Ensures the proper localization of the mRNA of the bicoid gene to the anterior regions of the oocyte thus playing a fundamental role in the establishment of the polarity of the oocyte. May bind the bcd mRNA. (UniProtKB:P28750) FBgn0034542 UniProtKB "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. (UniProtKB:A1ZBY1)" FBgn0050211 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034539 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to several human genes including LYZ (lysozyme); LYZL1 (lysozyme like 1); and LYZL2 (lysozyme like 2). FBgn0034538 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in adult heart. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to several human genes including LYZ (lysozyme); LYZL1 (lysozyme like 1); and LYZL2 (lysozyme like 2). FBgn0034530 Alliance Involved in centrosome cycle. Located in pericentriolar material. Is expressed in embryonic dorsal epidermis; embryonic foregut; embryonic proventriculus inner layer; and embryonic ventral epidermis. FBgn0034528 Alliance Predicted to enable telomerase inhibitor activity. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). FBgn0050147 FlyBase Gene Snapshot Hillarin (Hil) encodes a W180-domain protein that affects cytokinesis through interactions with the Septin family member encoded by pnut in the developing nervous system. FBgn0034523 FlyBase Gene Snapshot "Nnf1a (Nnf1a) encodes a component of the Mis12 complex, which is an essential constituent of the kinetochore." FBgn0028622 FlyBase Gene Snapshot quasimodo (qsm) encodes a light-responsive factor of the circadian clock. It controls the rhythmic firing of clock neurons via the K[+] channel and the Na[+] K[+] Cl[-] cotransporter encoded by Shaw and NKCC respectively. FBgn0034521 FlyBase Gene Snapshot "Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1) encodes an enzyme involved in the synthesis of paucimannose N-glycans. It is required in the CNS, with involvement in locomotion, brain development and lifespan." FBgn0034517 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in eye. FBgn0043536 FlyBase Gene Snapshot "Odorant-binding protein 57d (Obp57d) encodes a member of the odorant-binding protein family. It is involved in taste perception of middle- to long-chain fatty acids, influencing feeding and oviposition-site preference behavior." FBgn0050145 FlyBase Gene Snapshot "Odorant-binding protein 57e (Obp57e) encodes a member of the odorant-binding protein family. It is involved in taste perception of middle- to long-chain fatty acids, influencing feeding and oviposition-site preference behavior." FBgn0050148 Alliance Predicted to enable carbohydrate binding activity. FBgn0034514 Alliance Involved in gastrulation. Located in vesicle. FBgn0034491 FlyBase Gene Snapshot Hormone-sensitive lipase (Hsl) encodes a protein involved in lipid storage. FBgn0010411 FlyBase Gene Snapshot Ribosomal protein S18 (RpS18) encodes a ribosomal protein located at the top of the head of the 40S subunit and contacts several helices of the 18S rRNA. FBgn0034493 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0026136 UniProtKB Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (UniProtKB:O96863) FBgn0034504 Alliance Is expressed in organism. FBgn0034505 Alliance Is expressed in spermatozoon. FBgn0034509 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q9V931) FBgn0043534 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q8MKJ4) FBgn0043535 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q8MKK0) FBgn0034510 Alliance "Predicted to enable protein transmembrane transporter activity. Predicted to be involved in post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Ssh1 translocon complex." FBgn0034507 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0034503 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA and MtnB genes. (UniProtKB:A1ZBT5)" FBgn0034501 Alliance "Is expressed in several structures, including amnioserosa; amnioserosa primordium; clypeo-labral anlage in statu nascendi; clypeo-labral primordium; and dorsal ectoderm." FBgn0034500 Alliance "Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic salivary gland duct; epithelium; and gut section. Orthologous to human DHRSX (dehydrogenase/reductase X-linked)." FBgn0034499 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; embryonic/larval posterior spiracle; and gut section." FBgn0034498 Alliance Predicted to enable voltage-gated calcium channel activity. Predicted to be part of voltage-gated calcium channel complex. Is expressed in organism. Orthologous to human CACHD1 (cache domain containing 1). FBgn0034497 Alliance Enables phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; adult heart; and organism. Orthologous to human SLC25A3 (solute carrier family 25 member 3). FBgn0034494 Alliance Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in adult brain cell body rind; adult brain perineurial glial cell; adult head; and organism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to several human genes including SLC5A6 (solute carrier family 5 member 6). FBgn0003114 FlyBase Gene Snapshot "plutonium (plu) encodes a protein that binds to and activates the kinase encoded by png. plu mutants are female sterile, and they result in embryos with giant nuclei due to failure to translate CycB mRNA resulting in DNA replication in the absence of mitosis." FBgn0005655 UniProtKB Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. (UniProtKB:P17917) FBgn0034481 Alliance Predicted to enable calcium ion binding activity. Is expressed in chordotonal neurons; dorsal sensory complex proper primordium; and embryonic head sensory system. Orthologous to human EFCAB2 (EF-hand calcium binding domain 2). FBgn0011869 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034484 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0011870 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034487 Alliance Predicted to be involved in cilium assembly and regulation of neuron projection development. Predicted to colocalize with microtubule. Is expressed in embryonic anal pad; embryonic head sensory system; embryonic hindgut; embryonic large intestine; and sensory nervous system primordium. Orthologous to human EFHC2 (EF-hand domain containing 2). FBgn0025720 FlyBase Gene Snapshot Arginyltransferase 1 (Ate1) encodes a putative arginyltransferase involved in protein arginylation based on orthology. FBgn0034490 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4). FBgn0034489 FlyBase Gene Snapshot "pickpocket 6 (ppk6) encodes a member of the DEG/ENaC family, whose members act as non-voltage-gated cation channels. DEG/ENaC family members have been implicated in the maintenance of sodium gradients across epithelial membranes, as well as in diverse sensory modalities, which include gustatory chemosensation, mechanosensation, hygrosensation, and nociception." FBgn0034488 Alliance "Predicted to enable 2-hydroxyacyl-CoA lyase activity and thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; gut section; head epidermis primordium; and mesoderm. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1)." FBgn0034483 Alliance Orthologous to human AKTIP (AKT interacting protein). FBgn0034480 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0050212 Alliance Predicted to enable AGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034471 Alliance Predicted to enable odorant binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in antenna and sense organ. FBgn0043533 Alliance Predicted to enable odorant binding activity. Involved in sexual reproduction. Located in extracellular space. FBgn0034472 Alliance Predicted to enable protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). FBgn0050215 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050218 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011897 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034475 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid (By similarity). May function in both olfactory and gustatory systems. (UniProtKB:Q9V8Y9) FBgn0034476 FlyBase Gene Snapshot "Toll-7 (Toll-7) encodes a plasma membrane Toll receptor that binds to viral glycoproteins, leading to the activation of antiviral defenses including autophagy." FBgn0043532 Alliance Predicted to enable odorant binding activity. Involved in sexual reproduction. Located in extracellular space. FBgn0034474 Alliance Predicted to enable odorant binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic antennal sense organ; embryonic maxillary sensory complex; labellar taste bristle; and labellum. FBgn0034473 FlyBase Gene Snapshot "Odorant receptor 56a (Or56a) encodes an olfactory receptor that functions in conjunction with the olfactory coreceptor encoded by Orco. The product of Or56a elicits a strong avoidance behavior in presence of the odor geosmin, a landmark of harmful microbes." FBgn0050454 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011848 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011849 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011850 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050452 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0002716 FlyBase Gene Snapshot meiotic W68 (mei-W68) encodes a protein thought to form a dimer with the TopoVIA subunit encoded by mei-P22 and is required for the formation of double strand breaks during meiosis. FBgn0026378 UniProtKB "Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). (UniProtKB:Q9V8W3)" FBgn0034454 Alliance Predicted to enable Hsp70 protein binding activity; Hsp90 protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be located in cytosol and nucleus. Orthologous to human PACRG (parkin coregulated). FBgn0034455 Alliance "Predicted to enable disulfide oxidoreductase activity. Predicted to be active in membrane-bounded organelle. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human TMX2 (thioredoxin related transmembrane protein 2)." FBgn0034456 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in labellar taste bristle; leg taste bristle chemosensory neurons; proboscis; and tarsal segment. FBgn0034457 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of terminal organ and terminal organ. FBgn0034459 Alliance Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cilium. Orthologous to human TTLL13 (tubulin tyrosine ligase like 13) and TTLL6 (tubulin tyrosine ligase like 6). FBgn0034464 Alliance Is expressed in spermatozoon. FBgn0028372 Alliance Located in endoplasmic reticulum and sperm flagellum. Part of ubiquitin ligase complex. Is expressed in wing hinge primordium and wing pouch. Orthologous to human UBAC1 (UBA domain containing 1). FBgn0034468 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q9V8Y2) FBgn0034470 UniProtKB Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (UniProtKB:Q8SY61) FBgn0046879 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in antenna; antennal sense organ; anterior wing margin; and embryonic antennal sense organ. FBgn0046880 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in adult labral sense organ; dorsal cibarial sense organ; embryonic antennal sense organ; and embryonic maxillary sensory complex. FBgn0034467 Alliance Is expressed in spermatozoon. FBgn0015949 FlyBase Gene Snapshot "hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb." FBgn0034462 Alliance Is expressed in wing anterior compartment and wing pouch. FBgn0034458 Interactive Fly "ionotropic receptor for fatty acids - IR56d neurons are broadly responsive to short-, medium-, and long-chain fatty acids - genetic deletion of IR56d selectively disrupts response to medium-chain fatty acids - along with GR64f, necessary for proboscis extension response (PER) to medium-chain fatty acids - sweet GRN activation requires the function of IR25a, IR76b and IR56d" FBgn0050223 Alliance Predicted to enable CAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034452 Alliance "Involved in cilium assembly. Located in non-motile cilium. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19)." FBgn0034451 FlyBase Gene Snapshot "Tubulin-binding cofactor B (Tbcb) encodes one of the cofactors required for the assembly of functional alpha/beta-Tubulin dimers needed for microtubule assembly. It is essential for microtubule-associated transport and cell polarity, but not for cell division." FBgn0034422 UniProtKB Probable methyltransferase required to silence rDNA. (UniProtKB:Q7K2B0) FBgn0010434 UniProtKB An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development. (UniProtKB:Q9V8R9) FBgn0004003 FlyBase Gene Snapshot windbeutel (wbl) encodes a Toll signaling pathway member protein residing in the endoplasmic reticulum. It is required for the transport of the product of pip to the Golgi in ovarian follicle cells. FBgn0034423 FlyBase Gene Snapshot "testis-specifically expressed bromodomain containing protein-2 (tbrd-2) encodes a protein required for male fertility. It interacts with the products of tbrd-1, tbrd-3 and testis-specific TAFs." FBgn0003254 FlyBase Gene Snapshot "ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells." FBgn0034428 Alliance Predicted to enable aralkylamine N-acetyltransferase activity. FBgn0034429 Alliance Predicted to enable aralkylamine N-acetyltransferase activity. FBgn0013954 FlyBase Gene Snapshot FK506-binding protein 12kD (Fkbp12) encodes a protein that binds the intracellular calcium channel encoded by RyR in an oxidation dependent manner. Loss of the binding between the products of Fkbp12 and RyR results in increased calcium leak and reduced muscle function. FBgn0034432 Alliance "Predicted to enable fatty-acyl-CoA binding activity; long-chain fatty acyl-CoA dehydrogenase activity; and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic salivary gland duct; embryonic/larval muscle system; and salivary gland body primordium. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain)." FBgn0034435 Alliance "Involved in negative regulation of translation. Located in cytosol. Part of translation repressor complex. Is expressed in several structures, including adult head; spermatocyte; and testis." FBgn0034436 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head; adult midgut progenitor cell; embryonic midgut chamber; embryonic/larval midgut; and gastric caecum. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0034437 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0034439 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0034440 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0034441 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0034442 Alliance "Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Predicted to be involved in superoxide metabolic process. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4)." FBgn0028981 Alliance Predicted to enable UCG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050225 Alliance Predicted to enable GUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050326 Alliance Predicted to enable GUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012051 FlyBase Gene Snapshot "Calpain-A (CalpA) encodes a calcium-dependent modulatory protease that cleaves its substrates in a limited fashion. During patterning and division in the blastoderm embryo, CalpA product cleaves the NF-kappaB inhibitor and the cell cycle regulator encoded by cact and CycB, respectively. CalpA product also regulates dendritic prunning of sensory neurons." FBgn0040273 UniProtKB "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development. (UniProtKB:Q9V460)" FBgn0013325 UniProtKB "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. (UniProtKB:P46222)" FBgn0034446 Alliance Predicted to enable GTP binding activity and GTPase activity. Involved in cilium assembly. Predicted to be located in cilium. Predicted to be active in axoneme. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6). FBgn0034447 Alliance Predicted to enable actin filament binding activity and lamin binding activity. Predicted to be involved in nuclear migration along microtubule. Predicted to be active in nuclear membrane. Is expressed in adult brain and adult pars intercerebralis. Orthologous to human TMEM201 (transmembrane protein 201). FBgn0020440 FlyBase Gene Snapshot "Focal adhesion kinase (Fak) encodes a non-Receptor Tyrosine kinase (nRTK) that is involved in signaling and cytoskeletal dynamics integrating signals from RTKs and integrins. Its function has been described in multiple contexts including embryonic muscle attachement, morphogensis of the optic stalk, synaptic growth and transmission, and in the regulation of RTK-MAP kinase signaling in epithelia." FBgn0034443 Alliance "Enables cysteine-type endopeptidase inhibitor activity. Involved in long-term memory and short-term memory. Located in endomembrane system. Is expressed in several structures, including adult brain; adult mushroom body; embryonic/larval garland cell; eye; and prothoracic gland." FBgn0034438 Alliance "Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including adult head; adult heart; mesoderm; muscle cell; and visceral mesoderm derivative. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1)." FBgn0034433 FlyBase Gene Snapshot Endophilin B (EndoB) encodes a protein belonging to the endophilin protein family that functions in the process of membrane binding and deformation. It contributes to oogenesis and fecundity. FBgn0034430 FlyBase Gene Snapshot "Myb-interacting protein 40 (mip40) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle." FBgn0034427 Alliance Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). FBgn0034426 Alliance Predicted to enable aralkylamine N-acetyltransferase activity. FBgn0034425 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium." FBgn0034408 FlyBase Gene Snapshot serrano (sano) encodes an apically-enriched cytosolic protein that contributes to trachea development and to the planar cell polarity pathway through binding to the product of dsh. FBgn0034411 Alliance Predicted to enable DNA binding activity. Predicted to be located in nucleus. FBgn0004168 FlyBase Gene Snapshot "5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT1A has been implicated in several aspects of adult behavior, including baseline sleep, aggression, courtship, as well as memory formation." FBgn0027535 UniProtKB "Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. (UniProtKB:Q9XZ08)" FBgn0034419 Alliance "Predicted to enable acylglycerol lipase activity and lysophospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase) and ABHD12B (abhydrolase domain containing 12B)." FBgn0034418 Alliance "Located in cytoplasm. Is expressed in several structures, including Bolwig organ; adult head; embryonic anal pad; embryonic hindgut; and ganglia. Orthologous to several human genes including ANKRD13B (ankyrin repeat domain 13B)." FBgn0050125 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neurons; labellar taste bristle; labral sense organ neurons; and organism subdivision. FBgn0041702 Alliance Is expressed in central brain primordium and organism. FBgn0014269 Alliance "Involved in lymph gland development; mitotic chromosome condensation; and regulation of circadian rhythm. Located in chromosome, centromeric region. Part of euchromatin and pericentric heterochromatin. Is expressed in several structures, including central brain primordium; ganglia; mesoderm; and ventral nerve cord primordium." FBgn0028669 Alliance "Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A2 (ATPase H+ transporting V0 subunit a2)." FBgn0050227 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034379 Alliance Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. FBgn0053147 FlyBase Gene Snapshot Heparan sulfate 3-O sulfotransferase-A (Hs3st-A) encodes a heparan sulfate modifying enzyme that transfers a sulfate group to the 3-O position of glucosamine residues of heparan sulfate. It regulates adult midgut homeostasis by repressing EGFR signaling. FBgn0034387 Alliance "Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval tracheal section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1)." FBgn0050229 Alliance Predicted to enable CUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034391 Alliance Predicted to be active in extracellular space. Is expressed in embryonic dorsal epidermis; embryonic esophagus; embryonic head epidermis; embryonic ventral epidermis; and spermatozoon. FBgn0010551 Alliance "Predicted to be involved in mitochondrion organization. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval muscle system. Orthologous to human PHB2 (prohibitin 2)." FBgn0034399 Alliance Is expressed in wing hinge primordium and wing pouch. FBgn0034402 Alliance Predicted to be involved in RNA splicing. Predicted to be part of U2-type spliceosomal complex and post-mRNA release spliceosomal complex. Is expressed in organism. Orthologous to human YJU2B (YJU2 splicing factor homolog B). FBgn0004240 FlyBase Gene Snapshot Diptericin A (DptA) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. FBgn0034407 FlyBase Gene Snapshot Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. FBgn0034406 Alliance "Enables serine hydrolase activity. Predicted to be involved in epoxide metabolic process and juvenile hormone catabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1)." FBgn0010053 FlyBase Gene Snapshot Juvenile hormone epoxide hydrolase 1 (Jheh1) expression changes are associated with increased tolerance to oxidative stress. FBgn0034403 Alliance Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to be active in microtubule cytoskeleton. FBgn0034401 FlyBase Gene Snapshot "Methionyl-tRNA synthetase (MetRS) encodes an enzyme that catalyzes the covalent attachment of methionine to methionyl-tRNA, an essential first step of protein translation." FBgn0034400 UniProtKB May be involved in protein traffic between late Golgi and early endosomes. (UniProtKB:A1ZBE8) FBgn0034398 Alliance "Predicted to be located in membrane. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm." FBgn0034396 Alliance Is expressed in Bolwig organ; embryonic head sensory system; embryonic large intestine; ganglia; and sensory nervous system primordium. Orthologous to human KLHL17 (kelch like family member 17). FBgn0034394 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in adult head; adult heart; embryonic/larval midgut primordium; and gut section. Orthologous to human SLC17A2 (solute carrier family 17 member 2). FBgn0010651 FlyBase Gene Snapshot Major Facilitator Superfamily Transporter 14 (MFS14) encodes a protein involved in response to hypoxia. FBgn0034392 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval salivary gland; plasmatocyte primordium; and salivary gland body primordium." FBgn0034390 Alliance Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). FBgn0034383 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in spermatocyte. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0034382 Alliance Enables fatty acid elongase activity. Involved in cuticle hydrocarbon biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult fat body; adult head; embryonic/larval oenocyte; and organism. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0050121 Alliance Is expressed in adult fat body. FBgn0034381 Alliance Predicted to enable L-amino acid transmembrane transporter activity; amino acid:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in response to lithium ion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain; adult gut; adult head; and adult ventral nerve cord. FBgn0034380 UniProtKB May act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). (UniProtKB:Q8MSY4) FBgn0023214 FlyBase Gene Snapshot ETS-domain lacking (edl) encodes a protein involved in Egfr signaling pathway regulation. It regulates the transcriptional repressor encoded by aop. FBgn0034372 Interactive Fly ubiquitin-like protein that functions in protein degradation - required for Wingless target gene expression FBgn0034371 Alliance "Enables protein-N-terminal asparagine amidohydrolase activity. Involved in negative regulation of glial cell proliferation; positive regulation of DNA endoreduplication; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Located in nucleus. Is expressed in several structures, including antennal lobe hub; embryonic epidermis; embryonic/larval central nervous system; embryonic/larval optic lobe; and glial cell. Orthologous to human NTAN1 (N-terminal asparagine amidase)." FBgn0011868 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050122 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; central brain primordium; ganglia; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to several human genes including HNRNPU (heterogeneous nuclear ribonucleoprotein U) and HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2)." FBgn0034368 FlyBase Gene Snapshot zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. FBgn0034329 FlyBase Gene Snapshot Bomanin Short 1 (BomS1) encodes a protein that belongs to a class of small secreted peptides released in the hemolymph upon Toll pathway activation during microbial infection. FBgn0034330 Alliance Involved in defense response to Gram-positive bacterium and response to mycotoxin. FBgn0025583 UniProtKB "Secreted immune-induced peptide induced by Toll signaling (PubMed:25915418, PubMed:29920489, PubMed:9736738). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489, PubMed:9736738). (UniProtKB:O77150)" FBgn0040736 UniProtKB "Secreted immune-induced peptide induced by Toll signaling (PubMed:29920489). Has a role in resistance bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489). Has no activity against the fungus C.glabrata in vitro (PubMed:29920489). (UniProtKB:Q9V8G0)" FBgn0040735 UniProtKB "Secreted immune-induced peptide induced by Toll signaling (PubMed:25915418, PubMed:29920489). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489). (UniProtKB:A1ZB62)" FBgn0040734 UniProtKB "Secreted immune-induced peptide induced by Toll signaling (PubMed:29920489). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489). (UniProtKB:A1ZB63)" FBgn0064237 UniProtKB "Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity). (UniProtKB:Q8T0R7)" FBgn0034335 FlyBase Gene Snapshot Glutathione S transferase E1 (GstE1) encodes an enzyme involved in glutathione metabolic processes and response to heat. FBgn0063498 Alliance Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. FBgn0063497 FlyBase Gene Snapshot Glutathione S transferase E3 (GstE3) encodes an enzyme involved in glutathione metabolic processes. FBgn0063496 FlyBase Gene Snapshot Glutathione S transferase E4 (GstE4) encodes an enzyme involved in glutathione metabolic processes. FBgn0063495 Alliance Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. FBgn0063494 FlyBase Gene Snapshot Glutathione S transferase E6 (GstE6) encodes an enzyme involved in glutathione metabolic processes. FBgn0063493 FlyBase Gene Snapshot "Glutathione S transferase E7 (GstE7) encodes a cytosolic enzyme that functions in detoxication. It has high catalytic activity with various isothiocyanates and the toxic environmental pollutants 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT)." FBgn0063492 Alliance Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in wing disc. FBgn0063491 FlyBase Gene Snapshot Glutathione S transferase E9 (GstE9) encodes an enzyme involved in glutathione metabolic processes. FBgn0027835 FlyBase Gene Snapshot Dodeca-satellite-binding protein 1 (Dp1) encodes a single-stranded nucleic acid binding protein that belongs to the vigilin protein family. It binds to target mRNAs and enhances their translation. FBgn0034345 Alliance Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including TPD52L2 (TPD52 like 2). FBgn0034346 Alliance Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). FBgn0034350 UniProtKB "Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. (UniProtKB:Q9V8I2)" FBgn0034351 UniProtKB "Mitochondrial tRNA N1-methyltransferase involved in mitochondrial tRNA maturation (PubMed:27131785, PubMed:34199774, PubMed:35663400). Component of mitochondrial ribonuclease P, a complex composed of rswl/MRPP1, scu/MRPP2 and mldr/MRPP3., which cleaves tRNA molecules in their 5'-ends (PubMed:27131785). Essential for the structural and functional integrity of mitochondria (PubMed:27131785, PubMed:34199774, PubMed:35663400). Function is essential for pupal development (PubMed:34199774, PubMed:35663400). (UniProtKB:Q7JUX9)" FBgn0034354 Alliance Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in adult head; embryonic/larval muscle system; organism; and trunk mesoderm. FBgn0034356 FlyBase Gene Snapshot Phosphoenolpyruvate carboxykinase 2 (Pepck2) encodes a putative mitochondrial enzyme that is predicted to convert oxaloacetate into phosphoenolpyruvate. FBgn0003067 FlyBase Gene Snapshot Phosphoenolpyruvate carboxykinase 1 (Pepck1) encodes an enzyme that converts oxaloacetate into phosphoenolpyruvate. It catalyzes the first committed step in gluconeogenesis and thus plays an essential role in glucose metabolism. FBgn0034360 Alliance "Predicted to enable tRNA-specific adenosine deaminase activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3)." FBgn0034362 Alliance Predicted to be active in cytoplasm. Is expressed in adult heart. Orthologous to human FAM136A (family with sequence similarity 136 member A). FBgn0034363 Alliance Predicted to be active in cytoplasm. Orthologous to human FAM136A (family with sequence similarity 136 member A). FBgn0034365 Alliance Predicted to enable carbohydrate binding activity and galactoside binding activity. Is expressed in adult head. Orthologous to human LGALS8 (galectin 8). FBgn0000566 FlyBase Gene Snapshot Cystathionine gamma-lyase (Cth) encodes a protein involved in glutathione biosynthesis. FBgn0034366 FlyBase Gene Snapshot "Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan." FBgn0034364 Alliance Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in L-cysteine catabolic process. Is expressed in embryonic ventral epidermis; embryonic/larval salivary gland; embryonic/larval salivary gland body; larval foregut atrium; and salivary gland body primordium. Orthologous to human CDO1 (cysteine dioxygenase type 1). FBgn0034361 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal pharyngeal muscle cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 47. Orthologous to human MRPS28 (mitochondrial ribosomal protein S28)." FBgn0050115 FlyBase Gene Snapshot Guanine nucleotide exchange factor in mesoderm (GEFmeso) encodes a protein that regulates the products of Rala and Cdc42. It is involved in leg morphogenesis and wing vein specification. FBgn0028496 Alliance "Is expressed in several structures, including CNS glial cell; embryonic central brain; ganglia; gut section; and sensory nervous system primordium." FBgn0034352 UniProtKB "Required for the assembly of axonemal inner and outer dynein arms (PubMed:34553759). Involved in the cytoplasmic preassembly of dyneins into complexes before their transport into cilia (PubMed:34553759). Essential for the development of axonemal dynein motors in the sensory cilium of mechanosensory chordotonal (Ch) neurons and sperm flagellum, and consequently, is required for the mechanotransduction process of hearing and sperm mobility (PubMed:34553759). (UniProtKB:A1ZB91)" FBgn0013983 FlyBase Gene Snapshot "immune deficiency (imd) encodes a canonic component of the immune deficiency pathway, which regulates the antibacterial response and other less characterized cellular processes." FBgn0063499 Alliance Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. FBgn0040733 UniProtKB "Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489). (UniProtKB:A1ZB64)" FBgn0034331 Alliance Predicted to be involved in defense response. Is expressed in embryonic midgut chamber. FBgn0034328 UniProtKB "Secreted immune-induced peptide induced by Toll signaling (PubMed:9736738). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). (UniProtKB:Q9V8F5)" FBgn0034300 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain and organism. Human ortholog(s) of this gene implicated in Smith-Magenis syndrome. Orthologous to several human genes including TCF20 (transcription factor 20). FBgn0028983 Alliance "Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval gut; embryonic/larval salivary gland; garland cell primordium; and gut section. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive nonsyndromic deafness 91; and peeling skin syndrome 5. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB2 (serpin family B member 2); and SERPINB6 (serpin family B member 6)." FBgn0040465 FlyBase Gene Snapshot Dorsal interacting protein 3 (Dlip3) encodes a transcription factor whose loss of function in the eye disc results in the appearance of extra photoreceptors. Dlip3 overexpression in the early eye disc results in antennal duplication and eye-to-antennal transformation. FBgn0003044 FlyBase Gene Snapshot "Polycomblike (Pcl) encodes a protein required for taste response to sugar. It regulates the expression of Ptx1, cad, nub, scro and GATAe in response to diet. The distribution of Pcl bound to chromatin in the sweet taste cells is nutrient dependent." FBgn0000057 FlyBase Gene Snapshot adipose (adp) encodes a protein involved in lipid metabolism and fat storage. FBgn0034307 Alliance Predicted to enable GTP binding activity. Orthologous to human NOA1 (nitric oxide associated 1). FBgn0034308 UniProtKB "Regulates lamellipodial actin dynamics in a Cortactin-dependent manner and is therefore likely involved in controlling actin branch density, actin-retrograde flow rates and lamellipodial protrusion. Functions by slowing the dissociation of Cortactin from Arp2/3 nucleated branches thereby increasing branch nucleation and junction stability (PubMed:31164339). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). (UniProtKB:Q8SX68)" FBgn0034312 FlyBase Gene Snapshot "CG10916 encodes a zinc ion binding protein with ubiquitin-protein transferase activity. It is involved in intracellular signal transduction, determination of lifespan, protein ubiquitination and hypoxia." FBgn0034318 Alliance Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. FBgn0000658 FlyBase Gene Snapshot "four-jointed (fj) encodes a type II transmembrane kinase. Through phosphorylation of the atypical cadherins encoded by ft and ds, it regulates control of planar polarity in epithelia and also growth via the Hippo/Warts pathway." FBgn0034321 Alliance Is expressed in embryonic/larval central nervous system and larval ventral nerve cord. FBgn0040737 Alliance Involved in Golgi organization and protein secretion. Located in endoplasmic reticulum. FBgn0034327 Alliance Predicted to enable kinase regulator activity and protein kinase A binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasm. Orthologous to human GSKIP (GSK3B interacting protein). FBgn0034313 Alliance Predicted to enable translation activator activity. Predicted to be involved in regulation of translational initiation. Is expressed in adult head and organism. Orthologous to human CTIF (cap binding complex dependent translation initiation factor). FBgn0027836 Alliance Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Is expressed in adult head. Orthologous to human GTPBP1 (GTP binding protein 1). FBgn0034310 UniProtKB Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). Facilitates the interaction between Nup93 and sec13 with msk (PubMed:20547758). (UniProtKB:A1YK02) FBgn0022238 FlyBase Gene Snapshot lola like (lolal) encodes a small BTB-domain protein related to the Trithorax group of chromatin regulators. lolal transcripts are found in oocytes and the protein translocates to embryonic nuclei after the maternal to zygotic transition. lolal homozygous germline clone embryos show reduced dpp expression during dorsal-ventral patterning. FBgn0034304 Alliance Predicted to enable signaling receptor binding activity. Predicted to be involved in protein retention in ER lumen. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human ANKRD13C (ankyrin repeat domain 13C). FBgn0062440 UniProtKB "Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. (UniProtKB:Q7JX57)" FBgn0001222 UniProtKB "DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. (UniProtKB:P22813)" FBgn0003520 FlyBase Gene Snapshot "staufen (stau) encodes a double-stranded RNA binding protein involved in mRNA localization. It contributes to anterior and posterior patterning, nervous system development and long term memory." FBgn0034301 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0034299 Alliance Predicted to enable UMP/dUMP kinase activity; nucleoside diphosphate kinase activity; and thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to be active in mitochondrion and nucleus. Is expressed in organism. Orthologous to human DTYMK (deoxythymidylate kinase). FBgn0041585 FlyBase Gene Snapshot olf186-F (olf186-F) encodes a plasma membrane localised protein that functions as a pore subunit of the store-operated calcium entry (SOCE) channel. FBgn0015522 Alliance Predicted to enable signaling receptor binding activity. Is expressed in embryonic/larval lymph gland; gonad; organism; primordial germ cell; and yolk nucleus. FBgn0050323 Alliance Predicted to be involved in proteolysis. FBgn0034281 Alliance Orthologous to human MORN3 (MORN repeat containing 3). FBgn0011589 Alliance Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Orthologous to human KCNH3 (potassium voltage-gated channel subfamily H member 3); KCNH4 (potassium voltage-gated channel subfamily H member 4); and KCNH8 (potassium voltage-gated channel subfamily H member 8). FBgn0034296 Alliance Involved in cold acclimation. FBgn0034294 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic midgut chamber; embryonic/larval anterior midgut; embryonic/larval midgut; and organism. FBgn0034290 Alliance Is expressed in photoreceptor neurons and yolk nucleus. FBgn0003140 FlyBase Gene Snapshot Protein phosphatase Y at 55A (PpY-55A) encodes a male serine/threonine phosphatase expressed in testis somatic cells. FBgn0050110 Alliance Is expressed in spermatozoon. FBgn0034282 UniProtKB "Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. (UniProtKB:Q9V895)" FBgn0034242 Alliance Predicted to be active in nucleus. Is expressed in organism. Orthologous to human PSME3IP1 (proteasome activator subunit 3 interacting protein 1). FBgn0040294 FlyBase Gene Snapshot Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway. FBgn0016701 FlyBase Gene Snapshot "Rab4 (Rab4) encodes a member of the Rab family, which are small Ras-like GTPases involved in vesicle trafficking. The product of Rab4 controls endocytic recycling and regulates synapse organization and neurotransmission in the nervous system. It also contributes to the sorting of cell adhesion molecules during epithelial morphogenesis and immune-mediators during the innate immune response." FBgn0029079 FlyBase Gene Snapshot icln (icln) encodes a cytosolic protein that functions as an assembly chaperone in the biogenesis of pre-mRNA processing small nuclear ribonucleoproteins (snRNPs) via interaction with Sm proteins. It is required in the motor system for viability and motor behaviour. FBgn0029006 UniProtKB E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation. (UniProtKB:Q9V853) FBgn0034251 Alliance "Predicted to enable 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1)." FBgn0050231 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034258 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:A1ZAX1)" FBgn0050108 Alliance Predicted to contribute to phosphatidic acid transfer activity. Predicted to be involved in phospholipid translocation. Predicted to be active in mitochondrial intermembrane space and nucleus. Orthologous to human TRIAP1 (TP53 regulated inhibitor of apoptosis 1). FBgn0050109 Alliance Predicted to contribute to phosphatidic acid transfer activity. Predicted to be involved in phospholipid translocation. Predicted to be active in mitochondrial intermembrane space and nucleus. Is expressed in adult heart. Orthologous to human TRIAP1 (TP53 regulated inhibitor of apoptosis 1). FBgn0034261 FlyBase Gene Snapshot Hermansky-Pudlak Syndrome 4 (HPS4) encodes a tethering factor that regulates gene silencing by small RNAs via endosomal trafficking. FBgn0045800 Alliance Is expressed in adult brain cell body rind. FBgn0063381 FlyBase Gene Snapshot C/D box small nucleolar RNA 2a (snoRNA:CD2a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3152 in 28SrRNA:CR45844. FBgn0063385 FlyBase Gene Snapshot C/D box small nucleolar RNA 3a (snoRNA:CD3a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A3478 and C3480 in 28SrRNA:CR45844. FBgn0063377 FlyBase Gene Snapshot C/D box small nucleolar RNA 4a (snoRNA:CD4a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1691 and G1692 in 28SrRNA:CR45844. FBgn0063384 FlyBase Gene Snapshot C/D box small nucleolar RNA 3b (snoRNA:CD3b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A3478 and C3480 in 28SrRNA:CR45844. FBgn0063383 FlyBase Gene Snapshot C/D box small nucleolar RNA 3c (snoRNA:CD3c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A3478 and C3480 in 28SrRNA:CR45844. FBgn0063376 FlyBase Gene Snapshot C/D box small nucleolar RNA 4b (snoRNA:CD4b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1691 and G1692 in 28SrRNA:CR45844. FBgn0063382 FlyBase Gene Snapshot C/D box small nucleolar RNA 3d (snoRNA:CD3d) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A3478 and C3480 in 28SrRNA:CR45844. FBgn0063388 FlyBase Gene Snapshot C/D box small nucleolar RNA 5a (snoRNA:CD5a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A28 in 18SrRNA:CR45838. FBgn0063375 FlyBase Gene Snapshot C/D box small nucleolar RNA 6a (snoRNA:CD6a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3348 in 28SrRNA:CR45844. FBgn0063374 FlyBase Gene Snapshot C/D box small nucleolar RNA 6b (snoRNA:CD6b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3348 in 28SrRNA:CR45844. FBgn0063380 FlyBase Gene Snapshot C/D box small nucleolar RNA 2b (snoRNA:CD2b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3152 in 28SrRNA:CR45844. FBgn0063379 FlyBase Gene Snapshot C/D box small nucleolar RNA 2c (snoRNA:CD2c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3152 in 28SrRNA:CR45844. FBgn0063378 FlyBase Gene Snapshot C/D box small nucleolar RNA 2d (snoRNA:CD2d) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3152 in 28SrRNA:CR45844. FBgn0063387 FlyBase Gene Snapshot C/D box small nucleolar RNA 5b (snoRNA:CD5b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A28 in 18SrRNA:CR45838. FBgn0063373 FlyBase Gene Snapshot C/D box small nucleolar RNA 6c (snoRNA:CD6c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3348 in 28SrRNA:CR45844. FBgn0063386 FlyBase Gene Snapshot C/D box small nucleolar RNA 5c (snoRNA:CD5c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A28 in 18SrRNA:CR45838. FBgn0034263 Alliance Is expressed in adult head. FBgn0034264 FlyBase Gene Snapshot "Dachs ligand with SH3s (Dlish) encodes an adapter protein that can bind to the products of dachs, ds, and ft. It is required for the normal growth of wings and legs via Dachsous-Fat signaling." FBgn0034266 Alliance Predicted to be involved in neuron projection development. Located in cytosol. Is expressed in embryonic/larval muscle system and embryonic/larval somatic muscle cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 10. Orthologous to human ATXN10 (ataxin 10). FBgn0034267 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. FBgn0034271 Alliance Predicted to enable SNARE binding activity. Predicted to be involved in endocytic recycling. Located in endosome. Part of GARP complex. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). FBgn0034272 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. FBgn0003545 FlyBase Gene Snapshot subito (sub) encodes a kinesin-6 homolog. Kinesin-6 proteins are known to bundle antiparallel microtubules. The product of sub is required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis. FBgn0034270 Alliance Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Used to study multiple congenital anomalies-hypotonia-seizures syndrome 2. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). FBgn0034269 Alliance Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Used to study hypomyelinating leukodystrophy 5. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 5. Orthologous to human HYCC1 (hyccin PI4KA lipid kinase complex subunit 1) and HYCC2 (hyccin PI4KA lipid kinase complex subunit 2). FBgn0034265 FlyBase Gene Snapshot Sorting nexin 16 (Snx16) encodes a protein that regulates synaptic growth at the neuromuscular junction. FBgn0028494 Alliance Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to several human genes including FAM13B (family with sequence similarity 13 member B). FBgn0027872 UniProtKB Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. (UniProtKB:Q9U9P7) FBgn0034262 UniProtKB Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes. (UniProtKB:Q8SXT3) FBgn0016059 Alliance "Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in embryonic development via the syncytial blastoderm. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; ectoderm; follicle cell; and lamina. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to several human genes including SEMA6A (semaphorin 6A); SEMA6B (semaphorin 6B); and SEMA6C (semaphorin 6C)." FBgn0034259 FlyBase Gene Snapshot P32 (P32) encodes an evolutionarily conserved mitochondrial protein that functions in presynaptic calcium signaling and neurotransmitter release as well as chromatin metabolism. FBgn0050106 UniProtKB "Receptor for the neuropeptide CCHamide-1 (PubMed:21110953, PubMed:23293632). Plays a role in the modulation of starvation-induced olfactory behavior where starved flies show increased responsiveness to food odorants, repellants and pheromones (PubMed:24067446). Contributes to regulation of sleep latency (the time required to fall asleep), amount of sleep and depth of sleep (arousability) (PubMed:30246807, PubMed:36958331). Involved in modulation of PDP1 and PDF levels in s-LNv (small ventral lateral neurons) clock neurons in response to CCHa1 released by DN1a (anterior dorsal neurons 1) clock neurons, to regulate morning activity (PubMed:30246807). In a subset of dopaminergic cells in the protocerebral anterior medial (PAM) cluster involved in suppressing arousability in response to CCHa1 secreted by gut enteroendocrine cells (PubMed:36958331). (UniProtKB:A1ZAX0)" FBgn0034253 Alliance "Is expressed in several structures, including embryonic epipharynx; embryonic hypopharynx; embryonic ventral epidermis; epithelium; and gut section." FBgn0034255 FlyBase Gene Snapshot "Oxpecker (Oxp) is an evolutionarily young, tandem duplicate gene of the piRNA pathway member encoded by rhi. It supports female fertility and transposon silencing in the female germline." FBgn0004400 FlyBase Gene Snapshot "rhino (rhi) encodes a germline-restricted heterochromatin protein 1 required for fertility. It silences germline transposable elements by promoting transcription of the small RNAs encoded in Piwi-RNA clusters. rhi (as well as its interacting partners del and cuff) shows ovary-biased expression, but it is also expressed and functional in the testis." FBgn0050333 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050105 Alliance Predicted to be involved in RNA catabolic process. Predicted to be part of ribonuclease H2 complex. Is expressed in embryonic brain and organism. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2C (ribonuclease H2 subunit C). FBgn0034249 Alliance Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm. Is expressed in leg. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). FBgn0034248 Alliance Predicted to enable unfolded protein binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in embryonic/larval midgut and organism. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 12. Orthologous to human PET100 (PET100 cytochrome c oxidase chaperone). FBgn0034247 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; adult midgut; and embryonic hypopharynx. Orthologous to human SLC2A8 (solute carrier family 2 member 8). FBgn0034246 FlyBase Gene Snapshot "Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs." FBgn0034245 Alliance "Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex III. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human UQCR11 (ubiquinol-cytochrome c reductase, complex III subunit XI)." FBgn0034243 Alliance "Enables GTPase activity. Involved in compound eye morphogenesis and ribosomal large subunit export from nucleus. Located in nucleolus. Colocalizes with nucleoplasm. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and mesoderm. Orthologous to human GNL2 (G protein nucleolar 2)." FBgn0011879 Alliance Predicted to enable GCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0010620 FlyBase Gene Snapshot "CG10939 encodes a protein that functions as a scaffold linking the plasma membrane and cytoskeletal linker proteins encoded by Mer and Moe. Via interaction with the products of Slik and flw, it regulates the activity of the products of Mer and Moe in epithelial cell adhesion." FBgn0016697 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:Q95083)" FBgn0022029 Alliance "Predicted to enable uridine kinase activity. Predicted to be involved in pyrimidine-containing compound salvage. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; gland; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1)." FBgn0034215 FlyBase Gene Snapshot Methylthioadenosine phosphorylase (Mtap) encodes an enzyme that plays a key role in the methionine salvage pathway and in the production of endogenous cellular adenine. FBgn0034217 FlyBase Gene Snapshot Lethal hybrid rescue (Lhr) encodes a protein required to repress transposable element and satellite DNA expression. It also has a gain-of-function phenotype of causing lethality in F1 male hybrids between D. melanogaster and D. simulans. FBgn0034218 Alliance Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). FBgn0034221 Alliance Predicted to enable serine-type endopeptidase activity. Involved in negative regulation of hemocyte proliferation. FBgn0024196 FlyBase Gene Snapshot roadblock (robl) encodes a dynein-associated protein involved in intracellular transport mediated by Dynein. It contributes to dendrite morphogenesis and mushroom body development. FBgn0028953 Alliance Predicted to enable nucleic acid binding activity. Is expressed in organism. FBgn0022987 Alliance "Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm. Is expressed in organism and ovary. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2)." FBgn0034225 FlyBase Gene Snapshot veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase. FBgn0050104 FlyBase Gene Snapshot Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine. FBgn0050103 Alliance Predicted to enable hydrolase activity. Predicted to be involved in AMP catabolic process. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). FBgn0034229 Alliance Predicted to enable cysteine-type endopeptidase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; adult heart; embryonic ventral epidermis; and sensory nervous system primordium. FBgn0034230 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGEF1B (RasGEF domain family member 1B). FBgn0034232 Alliance Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be part of Mpp10 complex and small-subunit processome. Is expressed in organism. Orthologous to human IMP3 (IMP U3 small nucleolar ribonucleoprotein 3). FBgn0034237 UniProtKB "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q0E940)" FBgn0028382 UniProtKB PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity). (UniProtKB:Q9V3G3) FBgn0034240 FlyBase Gene Snapshot "Misexpression suppressor of ras 4 (MESR4) encodes a plant homeodomain finger protein required for proper activation of the EGFR signaling pathway. It contributes to innate immunity, cellular response to hypoxia, regulation of fat storage, and embryonic development." FBgn0010409 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPL18A (ribosomal protein L18a). FBgn0034231 UniProtKB "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. (UniProtKB:Q9V831)" FBgn0034224 Alliance Involved in negative regulation of Notch signaling pathway. Located in nucleus. Is expressed in mesonotum. FBgn0034223 Alliance Predicted to enable zinc ion binding activity. Located in actin cytoskeleton and cytoplasm. Is expressed in embryonic/larval central nervous system. Orthologous to human LMCD1 (LIM and cysteine rich domains 1) and TES (testin LIM domain protein). FBgn0028956 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic abdominal neuromere; eye disc morphogenetic furrow; and wing disc. FBgn0034219 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; eye disc morphogenetic furrow; and wing disc. FBgn0027506 Alliance Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Involved in oogenesis. Is expressed in nurse cell; oocyte; and organism. Human ortholog(s) of this gene implicated in centronuclear myopathy 1. Orthologous to human MTMR14 (myotubularin related protein 14). FBgn0025716 FlyBase Gene Snapshot "Brahma associated protein 55kD (Bap55) encodes a member of two chromatin remodeling complexes. As part of the Brahma complex, it is needed for cell growth and survival in the wing imaginal disc; as a member of the TIP60 complex, it is thought to regulate dendrite wiring specificity in olfactory projection neurons." FBgn0034214 UniProtKB "Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. (UniProtKB:Q7K4W1)" FBgn0050101 Alliance "Enables chitin binding activity. Predicted to be involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in several structures, including adult head; border follicle cell; embryonic epipharynx; embryonic head epidermis; and epidermis." FBgn0034210 Alliance Involved in defense response to bacterium. Is expressed in organism. FBgn0050232 Alliance Predicted to enable GCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034179 Alliance "Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm; plasma membrane; and ruffle. Is expressed in several structures, including adult head; cephalic furrow; head mesoderm; plasmatocyte primordium; and pole plasm. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to several human genes including INPP5K (inositol polyphosphate-5-phosphatase K)." FBgn0023172 FlyBase Gene Snapshot "Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction." FBgn0034182 Alliance Is expressed in adult head. FBgn0034183 Alliance Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. FBgn0034184 Alliance Orthologous to human KIAA0930 (KIAA0930). FBgn0026721 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Located in extracellular region. Is expressed in embryonic/larval fat body; embryonic/larval plasmatocyte; fat body/gonad primordium; plasmatocyte primordium; and yolk nucleus. Orthologous to human SPON1 (spondin 1). FBgn0034187 Alliance Enables RISC complex binding activity. Involved in positive regulation of miRNA-mediated gene silencing. Located in cytosol. Is expressed in germline cell; gonad; organism; and primordial germ cell. FBgn0034191 Alliance "Predicted to enable hydro-lyase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including adult heart; embryonic hindgut; and embryonic/larval midgut primordium. Orthologous to human ECHDC3 (enoyl-CoA hydratase domain containing 3)." FBgn0034194 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Involved in response to endoplasmic reticulum stress. Located in cytoplasm. Is expressed in adult head; antennal disc; dorsal mesothoracic pleura primordium; and leg disc. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). FBgn0000078 FlyBase Gene Snapshot Amylase distal (Amy-d) encodes one of three amylases encoded in the Drosophila genome. It is a digestive enzyme required for the hydrolysis of dietary starch. FBgn0034197 Alliance Predicted to enable chitin deacetylase activity. Predicted to be involved in carbohydrate metabolic process. FBgn0034198 Alliance Is expressed in embryonic/larval midgut and organism. FBgn0034199 FlyBase Gene Snapshot Growth-blocking peptide 1 (Gbp1) encodes a cytokine that regulates the humoral immune response. FBgn0034200 Alliance Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Located in extracellular region. Is expressed in adult fat body; amnioserosa; embryonic/larval fat body; and yolk nucleus. FBgn0050235 Alliance Predicted to enable CUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034205 Alliance Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm. FBgn0034204 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; sensory nervous system primordium; and ventral sensory complex primordium. FBgn0034202 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in embryonic/larval central nervous system and organism. FBgn0050234 Alliance Predicted to enable CUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034196 Alliance Predicted to be involved in cytoplasmic translation. FBgn0034195 Alliance "Involved in sexual reproduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1)." FBgn0000079 FlyBase Gene Snapshot Amylase proximal (Amy-p) encodes one of three amylases encoded in the Drosophila genome. It is a digestive enzyme required for the hydrolysis of dietary starch. FBgn0010591 UniProtKB "Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. (UniProtKB:Q9V7Y2)" FBgn0050460 Alliance "Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle system; and embryonic/larval somatic muscle cell." FBgn0034186 Alliance Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Is expressed in organism. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). FBgn0034181 Alliance Predicted to enable translation activator activity. Involved in positive regulation of translation. Is expressed in adult head and organism. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). FBgn0034180 FlyBase Gene Snapshot Eps15 homology domain containing protein-binding protein 1 (Ehbp1) encodes a protein that mediates asymmetric protein secretion. It regulates the trafficking and secretion of distinct Notch signaling components and extracellular membrane proteins. FBgn0034154 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0034156 Alliance Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). FBgn0011743 UniProtKB "Required for optimal embryo development, particularly under heat stress conditions (PubMed:34282725). Also appears to have a role in negatively regulating spermatocyte cyst development (PubMed:34282725). Under heat stress conditions, required for the correct organization and migration of nuclei during early embryogenesis, and therefore possibly functions by regulating embryonic actin networks during the heat stress response (PubMed:34282725). (UniProtKB:P45891)" FBgn0034157 FlyBase Gene Snapshot resilin (resilin) encodes an extracellular matrix constituent. FBgn0034158 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway and positive regulation of stem cell proliferation. Predicted to be active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Orthologous to human RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1) and RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2)." FBgn0034160 Alliance Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in adult heart. Orthologous to several human genes including MFAP4 (microfibril associated protein 4). FBgn0028737 UniProtKB EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (UniProtKB:O96827) FBgn0034162 Alliance Predicted to enable lysozyme activity. Involved in sexual reproduction. Located in extracellular space. FBgn0025827 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. FBgn0046999 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in embryonic/larval muscle system; embryonic/larval somatic muscle cell; and organism. FBgn0034166 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0004784 FlyBase Gene Snapshot inactivation no afterpotential C (inaC) encodes an eye-specific protein kinase C (PKC) involved in visual signaling. It is a member of the classical PKC family and acts downstream of the product of norpA to fine-tune the visual response. FBgn0003091 UniProtKB "PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). (UniProtKB:P05130)" FBgn0034168 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. FBgn0034172 Alliance Is expressed in adult head and organism. Orthologous to human C1orf43 (chromosome 1 open reading frame 43). FBgn0011867 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0004580 FlyBase Gene Snapshot Calbindin 53E (Cbp53E) encodes a 6 EF-hand domain-containing protein that regulates neuronal development. FBgn0034177 Alliance "Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in mitochondrial asparaginyl-tRNA aminoacylation. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial)." FBgn0026402 FlyBase Gene Snapshot Nuclear inhibitor of Protein phosphatase 1 (NiPp1) encodes a PP1 phosphatase inhibitor involved in axon guidance. FBgn0034176 FlyBase Gene Snapshot "prenyl protease type I (ste24a) encodes a protein that, along with the products of ste24b and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases." FBgn0034175 FlyBase Gene Snapshot "ste24b prenyl protease type I (ste24b) encodes a protein that, along with the products of ste24a and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24b plays an essential role in the male germline." FBgn0034173 Alliance Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity and peptidyl-cysteine S-nitrosylase activity. Predicted to be involved in canonical glycolysis; gluconeogenesis; and glyceraldehyde-3-phosphate metabolic process. Predicted to be active in cytosol. Is expressed in adult head; organism; and spermatozoon. FBgn0025833 Alliance Predicted to enable zinc ion binding activity. FBgn0014870 FlyBase Gene Snapshot P-element somatic inhibitor (Psi) encodes a protein that has dual roles in RNA processing and transcriptional regulation. It is required for activating Myc transcription. FBgn0025832 UniProtKB "Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. (UniProtKB:Q7K7A9)" FBgn0026754 Alliance "Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in sterol metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0010213 FlyBase Gene Snapshot "Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress." FBgn0015584 UniProtKB Responsible for physiological and behavioral changes in mated female flies. (UniProtKB:O46199) FBgn0034153 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0034152 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0034151 Alliance Is expressed in adult head. FBgn0053458 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in isolated microphthalmia 6. Orthologous to human PRSS56 (serine protease 56). FBgn0034132 Alliance Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0011260 FlyBase Gene Snapshot Semaphorin 2a (Sema2a) encodes a secreted member of the semaphorin protein family. It utilizes the receptor encoded by PlexB to mediate both repulsive and attractive axon guidance. It also utilizes the transmembrane semaphorin encoded by Sema1a as a receptor for dendrite process guidance. FBgn0034135 FlyBase Gene Snapshot "Syntrophin-like 2 (Syn2) encodes a component of the dystrophin glycoprotein complex (DGC) that may act in molecular scaffolding, recruiting signaling proteins to membranes and the DGC. It is required for locomotion and is involved in regulation of synaptic morphology." FBgn0034137 Alliance Predicted to enable protein serine/threonine kinase activity. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. Orthologous to several human genes including SBK1 (SH3 domain binding kinase 1). FBgn0016131 FlyBase Gene Snapshot Cyclin-dependent kinase 4 (Cdk4) encodes a protein that contributes to cell cycle progression and cell growth. It is involved in the regulation of JAK-STAT and TORC1 signalling pathways. FBgn0003274 UniProtKB Plays an important role in the elongation step of protein synthesis. (UniProtKB:P05389) FBgn0034144 Alliance Is expressed in adult head. FBgn0034145 UniProtKB Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (UniProtKB:A1ZAI5) FBgn0024232 Alliance Is expressed in embryonic/larval central nervous system and ventral midline of embryo. FBgn0013763 FlyBase Gene Snapshot "Imaginal disc growth factor 6 (Idgf6) is one of six genes in the IDGF family, which evolved from chitinases that lost their enzymatic activity. Idgf6 encodes a secreted protein that is highly expressed in larval fat body and adult head. Idgf6 product is involved in molting and egg chamber tube morphogenesis." FBgn0050463 UniProtKB "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:30158631). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:30158631). (UniProtKB:Q8MRC9)" FBgn0024315 UniProtKB May be an inorganic phosphate cotransporter. (UniProtKB:Q9V7S5) FBgn0024319 FlyBase Gene Snapshot Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development. FBgn0020506 FlyBase Gene Snapshot Amyrel (Amyrel) encodes an amylolytic activity protein that is expressed mainly in larval midgut. FBgn0040505 FlyBase Gene Snapshot "Anaplastic lymphoma kinase (Alk) encodes a protein that employs Ras/ERK and PI3K signalling pathways to function in multiple contexts including embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. Its ligand is the secreted protein encoded by jeb." FBgn0034143 UniProtKB Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (UniProtKB:A1ZAI3) FBgn0034142 UniProtKB Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (UniProtKB:Q960W6) FBgn0034141 Alliance Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). FBgn0034140 FlyBase Gene Snapshot Limostatin (Lst) encodes a peptide hormone produced by endocrine corpora cardiaca cells during starvation. It suppresses insulin production and secretion from insulin-producing cells by signaling through the G-protein coupled receptor encoded by PK1-R. FBgn0034138 FlyBase Gene Snapshot "Ribosomal protein S15 (RpS15) encodes a protein that plays a role in assembly, structure and function of the ribosome and functions in protein synthesis. It is phosphorylated by the kinase encoded by Lrrk, causing protein synthesis upregulation." FBgn0034136 FlyBase Gene Snapshot Dopamine transporter (DAT) encodes a dopamine transporter that mediates uptake of dopamine from the synaptic cleft. Its loss increases extracellular dopamine and is associated with behavioral phenotypes including increased activity and decreased sleep. FBgn0034131 Alliance Is expressed in spermatozoon. FBgn0050239 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050240 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0034094 Alliance Predicted to enable iron ion binding activity. Predicted to be involved in iron ion transport. Predicted to be active in endosome; extracellular space; and plasma membrane. FBgn0034095 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in intraciliary transport. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). FBgn0034104 Alliance Is expressed in spermatozoon. FBgn0034106 Alliance Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of dynein complex. FBgn0028424 FlyBase Gene Snapshot "Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females." FBgn0050100 Alliance Predicted to enable translation release factor activity. Predicted to be involved in translational termination. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 7 and hereditary spastic paraplegia 55. Orthologous to human MTRFR (mitochondrial translation release factor in rescue). FBgn0034110 FlyBase Gene Snapshot Autophagy-related 9 (Atg9) encodes an integral membrane protein acting as a membrane carrier for forming autophagosomes. It regulates TOR and JNK signaling pathways via autophagy. FBgn0034114 Alliance "Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335)." FBgn0010611 Alliance "Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Is expressed in several structures, including adult head; embryonic anal pad; embryonic head epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)." FBgn0034118 UniProtKB "Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes (PubMed:20144760). Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154 (PubMed:26341556). (UniProtKB:Q7JXF5)" FBgn0034126 Alliance Is expressed in adult heart. FBgn0034128 Alliance Is expressed in adult head. FBgn0034129 UniProtKB Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. Required for amino acid starvation-induced mono-ADP-ribosylation and subsequent formation of Sec bodies - which are stress assemblies that promote cell survival by preserving components of the ER exit sites (ERES) during amino-acid starvation. Catalyzes the mono-ADP-ribosylation of Sec16 which is essential for Sec body formation. (UniProtKB:A1ZAG4) FBgn0034127 Alliance Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Orthologous to human ME1 (malic enzyme 1) and ME3 (malic enzyme 3). FBgn0034120 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus." FBgn0034117 Alliance "Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process and oligosaccharide metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; epithelium; gut section; and somatic precursor cell. Human ortholog(s) of this gene implicated in Fabry disease; Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to several human genes including NAGA (alpha-N-acetylgalactosaminidase)." FBgn0034113 Alliance Predicted to enable protein tyrosine kinase inhibitor activity. Predicted to be located in nucleoplasm. Orthologous to human IBTK (inhibitor of Bruton tyrosine kinase). FBgn0034109 Alliance Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Part of catalytic step 2 spliceosome. Is expressed in organism. Orthologous to human PPIL2 (peptidylprolyl isomerase like 2). FBgn0050324 Alliance Is expressed in spermatozoon. FBgn0034105 Alliance Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. FBgn0024249 FlyBase Gene Snapshot cousin of atonal (cato) encodes a transcription factor involved in the development of the sensory nervous system. FBgn0001308 FlyBase Gene Snapshot "Kinesin heavy chain (Khc) encodes the force generating subunit of kinesin-1, a microtubule motor protein. It functions in the long-distance transport of cytoplasmic ""cargoes"" such as mRNAs, protein complexes, and organelles." FBgn0025519 Alliance Predicted to be involved in Golgi to plasma membrane transport. Is expressed in adult head. Orthologous to human CCDC93 (coiled-coil domain containing 93). FBgn0034099 Alliance Predicted to enable DNA binding activity. FBgn0034098 Interactive Fly a component of nuage in the germline that functions to repress selfish genetic elements - Aub and Ago3 are recruited to nuage to form a ping-pong complex assembled by Krimper - simultaneously binds the N-terminal regions of Aub and Ago3 to promote generation of new piRNA - Krimper enforces an antisense bias on piRNA pools by binding AGO3 in the Drosophila germline FBgn0034096 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus." FBgn0034093 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and organism. FBgn0034092 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). FBgn0034091 Alliance Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1 and autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to several human genes including DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). FBgn0050238 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050237 Alliance Predicted to enable CAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050093 Alliance "Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2)." FBgn0034059 Alliance "Enables signaling receptor binding activity. Predicted to be involved in vacuolar protein processing. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; gut section; and salivary gland body primordium. Orthologous to human TMEM208 (transmembrane protein 208)." FBgn0034060 Alliance Located in endomembrane system. Is expressed in germline cell. Orthologous to human TMEM131 (transmembrane protein 131). FBgn0034063 Alliance Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5). FBgn0034065 Alliance Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Located in cytoplasm and nuclear lamina. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC7 (exosome component 7). FBgn0034067 UniProtKB Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. (UniProtKB:Q8MSU3) FBgn0034069 Alliance Predicted to be active in cytosol and membrane. Orthologous to human C16orf89 (chromosome 16 open reading frame 89). FBgn0034070 FlyBase Gene Snapshot "SP2353 (SP2353) encodes a EGF-like- and LamininG-domain-containing protein. It interacts genetically with Dg, which encodes a extracellular matrix receptor. It regulates muscle homeostasis, rhabdomere differentiation and innate immune response." FBgn0014020 FlyBase Gene Snapshot "Rho1 (Rho1) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, microtubule dynamics, mophogenesis, border cell migration, cytokinesis, and wound repair." FBgn0034075 FlyBase Gene Snapshot Aspartyl beta-hydroxylase (Asph) may be involved in peptidyl-amino acid modification based on orthology. It might be involved in neurogenesis since lack of Asph function enhances the expanded htt-fragment-induced eye phenotype. FBgn0034076 Alliance Enables carboxylesterase activity. Involved in juvenile hormone catabolic process. FBgn0010052 FlyBase Gene Snapshot "Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior." FBgn0001124 FlyBase Gene Snapshot "Glutamate oxaloacetate transaminase 1 (Got1) encodes a cytosolic enzyme that catalyzes the interconversion of L-aspartate and alpha-ketoglutarate to oxaloacetate and L-glutamate. It is involved in glutamate and aspartate biosynthesis, gluconeogenesis and the malate-aspartate shuttle." FBgn0050094 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to be active in endoplasmic reticulum. FBgn0027091 Alliance Predicted to enable ATP binding activity; cysteine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic proventriculus; embryonic proventriculus inner layer; and organism. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). FBgn0034083 Alliance Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in adult head; embryonic/larval peripheral nervous system; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to several human genes including LRIG1 (leucine rich repeats and immunoglobulin like domains 1). FBgn0015754 FlyBase Gene Snapshot "Lissencephaly-1 (Lis-1) encodes a regulator of the cytoplasmic dynein-1 motor complex, binding to Dynein heavy chain and regulating dynein force production, microtubule affinity and velocity. It is involved in the transport of many of dynein's cargoes, including mRNPs, mitochondria and nuclei. The Lis-1 product is also a non-catalytic subunit of platelet-activating factor acetylhydrolase." FBgn0034087 FlyBase Gene Snapshot "clueless (clu) encodes a cytoplasmic ribonucleoprotein that is required for mitochondrial function. It functions in part with protein complexes at the outer mitochondrial membrane, such as the ribosome, the translocase complex TOM and the mitophagy proteins encoded by park and Pink1. Loss of clu causes mitochondrial oxidative damage, decreased ATP and lethality." FBgn0015295 FlyBase Gene Snapshot "SH2 ankyrin repeat kinase (Shark) encodes a non-receptor tyrosine kinase of the Syk family. It contributes to embryonic dorsal closure, chorion formation and engulfment of dying neurons." FBgn0034086 Alliance Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human PRKRIP1 (PRKR interacting protein 1). FBgn0034085 FlyBase Gene Snapshot Protein tyrosine phosphatase 52F (Ptp52F) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have motor axon defects. It regulates Tartan signaling in embryonic SNa motor neurons. FBgn0034084 Alliance Predicted to be involved in RNA splicing. Predicted to be part of U2-type catalytic step 1 spliceosome. Is expressed in embryonic/larval salivary gland; embryonic/larval salivary gland body; and organism. Orthologous to human YJU2 (YJU2 splicing factor homolog). FBgn0034073 UniProtKB Polynucleotide 5'-kinase involved in rRNA processing. (UniProtKB:A1ZA92) FBgn0034068 FlyBase Gene Snapshot "caspar (casp) encodes a protein that inhibits the immune deficiency pathway, but not the Toll pathway, by blocking cleavage and nuclear translocation of the product of Rel." FBgn0034066 Alliance Predicted to enable carbohydrate binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Part of EMC complex. Is expressed in adult head. Orthologous to human EMC7 (ER membrane protein complex subunit 7). FBgn0010590 Alliance Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; proteasome-associated autoinflammatory syndrome 3; and renal cell carcinoma. Orthologous to several human genes including PSMB6 (proteasome 20S subunit beta 6). FBgn0034062 Alliance "Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal head epidermis; embryonic ventral epidermis; and foregut anlage. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335)." FBgn0034061 UniProtKB "E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage (By similarity). As part of Ufm1 cascade, might play a role in the development of the neuromuscular junctions (PubMed:26872069). (UniProtKB:Q7K1Z5)" FBgn0020236 FlyBase Gene Snapshot ATP citrate lyase (Acly) encodes a protein involved in glucose homeostasis. FBgn0034058 Alliance Involved in peroxisome organization. Located in peroxisome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 14B. Orthologous to several human genes including PEX11A (peroxisomal biogenesis factor 11 alpha). FBgn0034057 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in Golgi apparatus. Is expressed in adult head; embryonic/larval central nervous system; and organism. Orthologous to several human genes including ZDHHC3 (zinc finger DHHC-type palmitoyltransferase 3). FBgn0050091 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0050090 Alliance Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. FBgn0050088 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0034046 UniProtKB "Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. (UniProtKB:Q7K2Y9)" FBgn0034047 UniProtKB "Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in antiviral innate immunity (PubMed:34261127, PubMed:34261128). Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (PubMed:34261127). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261127, PubMed:34261128). 3',2'-cGAMP is protected from poxin cleavage (PubMed:34261127). (UniProtKB:A1ZA55)" FBgn0034050 Alliance Predicted to be involved in cilium assembly. Predicted to be active in cilium. Is expressed in adult head. Human ortholog(s) of this gene implicated in Meckel syndrome. Orthologous to human TXNDC15 (thioredoxin domain containing 15). FBgn0034052 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS53 (serine protease 53). FBgn0034051 Interactive Fly "interacts with various factors involved in transcriptional regulation, regulates cell proliferation during eye morphogenesis, Lozenge activity during hematopoetic development and assembly of the COP9 signalosome complex" FBgn0015247 FlyBase Gene Snapshot Death-associated inhibitor of apoptosis 2 (Diap2) encodes a protein with ubiquitin E3-ligase activity that functions in the Imd pathway by conjugating the product of imd with K63-polyubiquitin chains. FBgn0034049 FlyBase Gene Snapshot bedraggled (bdg) encodes a putative transporter involved in the fate commitment of the R3/R4 pair of photoreceptor cells. FBgn0050085 FlyBase Gene Snapshot Rap1 interacting factor 1 (Rif1) encodes a protein that binds protein phosphatase PP1 and is required for temporal regulation of replication initiation. FBgn0022160 FlyBase Gene Snapshot Glycerophosphate oxidase 1 (Gpo1) encodes a mitochondrial inner membrane protein with glycerol-3-phosphate dehydrogenase activity. FBgn0034045 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult head; anal pad primordium; dorsal epidermis primordium; embryonic anal pad; and gut section. Orthologous to human SLC2A6 (solute carrier family 2 member 6)." FBgn0003130 FlyBase Gene Snapshot Pox neuro (Poxn) encodes a transcriptional factor that specifies the differences between mono-innervated external sensory (m-es) organs and poly-innervated external sensory (p-es) organs. Poxn expression in the external sensory organ precursor determines the fate to form larval p-es organs and adult chemosensory bristles. FBgn0050083 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0050082 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0034023 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult gustatory receptor neurons; appendage; leg mechanosensory bristle; and spermatozoon. FBgn0050469 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in mesothoracic leg taste bristle chemosensory neurons; metathoracic leg taste bristle chemosensory neurons; prothoracic leg taste bristle chemosensory neurons; and wing. FBgn0050468 FlyBase Gene Snapshot Ionotropic receptor 52c (Ir52c) encodes a protein involved in male mating behavior. FBgn0050464 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in reproductive behavior. Predicted to be located in membrane. Is expressed in mesothoracic leg taste bristle chemosensory neurons; metathoracic leg taste bristle chemosensory neurons; prothoracic leg; prothoracic leg taste bristle chemosensory neurons; and prothoracic tarsal bristle. FBgn0034025 UniProtKB "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:12829714). (UniProtKB:Q6WV20)" FBgn0050471 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0050467 Alliance "Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval midgut; embryonic/larval nervous system; and ganglia. Orthologous to human SAAL1 (serum amyloid A like 1)." FBgn0022097 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). (UniProtKB:Q9V7D2)" FBgn0034029 Alliance Predicted to enable guanyl-nucleotide exchange factor activity and translation initiation factor activity. Involved in cellular response to hypoxia. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 3. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). FBgn0050466 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. FBgn0034035 FlyBase Gene Snapshot "GDP-mannose pyrophosphorylase A (Gmppa) encodes a putative inactive enzyme that is predicted to act as a regulator of GDP-mannose pyrophosphorylase B (Gmppb) and thus, may be involved in the formation of GDP-mannose, a precursor for protein N-glycosylation." FBgn0023441 UniProtKB mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator. (UniProtKB:Q9BJZ5) FBgn0034033 Alliance "Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in PEHO syndrome. Orthologous to human ZNHIT3 (zinc finger HIT-type containing 3)." FBgn0013762 FlyBase Gene Snapshot "Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration." FBgn0024754 UniProtKB "May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (UniProtKB:O61491)" FBgn0034032 Alliance Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in nucleotide-sugar transmembrane transport. Predicted to be located in membrane. Is expressed in organism and yolk nucleus. Orthologous to human SLC35F5 (solute carrier family 35 member F5). FBgn0034030 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0034027 Alliance Is expressed in adult head. Orthologous to human FAM185A (family with sequence similarity 185 member A). FBgn0019968 FlyBase Gene Snapshot Kinesin heavy chain 73 (Khc-73) encodes a member of the Kinesin-3 family of microtubule-based transport motors. It facilitates endosomal transport during interphase and modulates cortical polarity during asymmetric neuroblast cell division. FBgn0034022 Alliance Predicted to enable actin binding activity and phospholipid binding activity. Predicted to be involved in cell projection assembly and membrane organization. Predicted to be active in actin cytoskeleton and cytoplasmic side of plasma membrane. Is expressed in wing hinge primordium and wing pouch. FBgn0034021 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic hypopharynx; embryonic ventral epidermis; and labral sensory complex." FBgn0013467 FlyBase Gene Snapshot igloo (igl) encodes a calmodulin binding protein. FBgn0033996 Alliance Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). FBgn0050081 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis. FBgn0034000 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 70. Orthologous to human RSRC1 (arginine and serine rich coiled-coil 1)." FBgn0034002 Alliance Predicted to enable nucleic acid binding activity. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). FBgn0034005 UniProtKB Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. (UniProtKB:Q9V7A4) FBgn0004698 FlyBase Gene Snapshot "Xeroderma pigmentosum, complementation group C (Xpc) encodes a protein involved in recognition of DNA damage and recruitment of nucleotide excision repair proteins." FBgn0013750 FlyBase Gene Snapshot "ADP ribosylation factor 6 (Arf6) belongs to the Arf family, which are members of the Ras superfamily of small GTPases. Arf proteins are involved in the regulation of vesicular trafficking mediating processes such as cargo-sorting, vesicle assembly and membrane fusion. Arf proteins regulate cell shape changes and cell movements in multiple organs." FBgn0034012 FlyBase Gene Snapshot "Hormone receptor 51 (Hr51) encodes a chromatin binding protein that regulates gene expression and contributes to axon guidance, neuron remodeling, mushroom body development and circadian rhythm regulation." FBgn0034013 FlyBase Gene Snapshot unc-5 (unc-5) encodes a netrin receptor involved in motor axon guidance and glial migration as well as netrin-mediated repulsion during salivary gland migration. FBgn0014865 FlyBase Gene Snapshot "Metchnikowin (Mtk) encodes an antifungal peptide that is secreted from the fat body during the systemic immune response, and is produced by various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency and/or Toll pathways." FBgn0000996 FlyBase Gene Snapshot double parked (dup) encodes an essential protein for the initiation of DNA replication due to its recruitment of the MCM helicase to replication origins. FBgn0011660 Alliance "Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to several human genes including PMS2 (PMS1 homolog 2, mismatch repair system component)." FBgn0034011 Alliance Located in extracellular region. Is expressed in embryonic/larval fat body and organism. FBgn0034008 Alliance Predicted to enable nucleic acid binding activity. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human GPANK1 (G-patch domain and ankyrin repeats 1). FBgn0034007 Alliance "Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in spermatozoon." FBgn0001187 FlyBase Gene Snapshot "Hexokinase C (Hex-C) encodes an enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexoses D-glucose, D-fructose and D-mannose to D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively. It mediates the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate." FBgn0034001 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human MRPL41 (mitochondrial ribosomal protein L41). FBgn0033999 Alliance Predicted to enable triglyceride lipase activity. Involved in sexual reproduction. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0033998 FlyBase Gene Snapshot relative of woc (row) encodes a zinc-finger protein involved in transcription regulation that is required for the factor encoded by HP1c to bind chromatin. FBgn0033995 FlyBase Gene Snapshot Golgi pH Regulator (GPHR) encodes an anion channel that regulates Golgi luminal pH. It is expressed in both ER and Golgi apparatus and is necessary for proper function of the secretory pathway. FBgn0033982 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V776) FBgn0033984 UniProtKB May have a role in assembling adherens junctions. (UniProtKB:Q9V780) FBgn0033985 Alliance Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Is expressed in eye. Orthologous to human FAIM (Fas apoptotic inhibitory molecule). FBgn0033987 FlyBase Gene Snapshot caskin (ckn) encodes a cytoplasmic adaptor protein that intreacts with the products of Lar and dock. It is required for axon growth and guidance. FBgn0033988 Alliance "Enables protein tyrosine kinase inhibitor activity. Involved in several processes, including female germline ring canal formation; muscle cell fate specification; and muscle organ morphogenesis. Located in cytoplasm and plasma membrane. Is expressed in several structures, including anal pad primordium; anlage in statu nascendi; antennal anlage; central brain anlage; and mesoderm. Orthologous to human SH3BP5L (SH3 binding domain protein 5 like)." FBgn0015371 FlyBase Gene Snapshot "charlatan (chn) encodes a C2H2 zinc-finger transcriptional factor that regulates multiple genes, including emc, hry, ac and Delta. It functions in sensory neurons, photoreceptors, blood cells, muscle precursors and intestinal precursors." FBgn0033994 UniProtKB RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA). (UniProtKB:Q7K3B9) FBgn0033993 Alliance "Predicted to enable chromatin insulator sequence binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in chromosome. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; and embryonic hypopharynx." FBgn0033990 Alliance Is expressed in organism. FBgn0033989 UniProtKB May play a role in the maintenance of the structure of mitochondrial cristae. (UniProtKB:Q9V784) FBgn0050241 Alliance Predicted to enable CUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033983 UniProtKB Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. (UniProtKB:Q9V778) FBgn0027596 FlyBase Gene Snapshot Kank (Kank) encodes a microtubule plus-end binding protein. FBgn0033951 Alliance Is expressed in organism. FBgn0033955 Alliance Enables acetate transmembrane transporter activity. Involved in acetate transmembrane transport. Predicted to be active in plasma membrane. FBgn0010388 FlyBase Gene Snapshot Drosocin (Dro) encodes an o-Glycosylated antibacterial peptide with activity against Gram-negative and Gram-positive bacteria. It is expressed in the fat body during the systemic immune response and is expressed in various epithelia. The expression of Dro is regulated at the transcriptional level mostly by the immune deficiency pathway. FBgn0012042 FlyBase Gene Snapshot "Attacin-A (AttA) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body and various epithelia under the regulation of the immune deficiency and, to a lesser extent, Toll pathways." FBgn0041581 FlyBase Gene Snapshot Attacin-B (AttB) encodes an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria. FBgn0050476 FlyBase Gene Snapshot aveugle (ave) encodes an adaptor protein that binds to the scaffolding protein encoded by cnk and promotes the activation of the product of Raf by recruiting the product of ksr. FBgn0033961 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). FBgn0015602 FlyBase Gene Snapshot "Boundary element-associated factor of 32kD (BEAF-32) encodes a DNA-binding protein with binding sites near transcription start sites. Its roles include chromatin domain insulator function, gene regulation and genome organization." FBgn0033968 Alliance Involved in wing disc development. Is expressed in anterior-posterior compartment boundary of the wing disc; embryonic foregut; embryonic proventriculus; and embryonic rectum. FBgn0028434 FlyBase Gene Snapshot "Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination." FBgn0033973 Alliance Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Part of BLOC-3 complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 1 and oculocutaneous albinism. Orthologous to human HPS1 (HPS1 biogenesis of lysosomal organelles complex 3 subunit 1). FBgn0013773 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V769) FBgn0015714 FlyBase Gene Snapshot Cytochrome P450-6a17 (Cyp6a17) encodes a member of the cytochrome P450 (CYP) family of proteins involved in the oxidation of diverse organic substrates. Cyp6a17 expression in the mushroom bodies of the brain is regulated by cAMP-dependent protein kinase (PKA) and is required for temperature preference behavior. FBgn0033978 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V771) FBgn0033979 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:P82711) FBgn0033980 FlyBase Gene Snapshot Cyp6a20 (Cyp6a20) encodes a protein that may function to degrade aggression-promoting pheromones based on indirect observations such as its expression pattern and the increased aggressive behavior shown in Cyp6a20 mutants. FBgn0013772 UniProtKB Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q27593) FBgn0013771 UniProtKB Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q27594) FBgn0033972 UniProtKB Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (UniProtKB:Q7K1Y4) FBgn0027783 FlyBase Gene Snapshot Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation. FBgn0033971 FlyBase Gene Snapshot CG10209 encodes a DNA binding nuclear apoptosis-inducing factor involved in the apoptotic process. FBgn0016684 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; Malpighian tubule tip cell primordium; adult head; and embryonic/larval midgut primordium." FBgn0033969 Alliance Predicted to enable phosphopentomutase activity. Predicted to be involved in purine ribonucleoside salvage. Is expressed in spermatozoon. Orthologous to human PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2 like 1). FBgn0001319 FlyBase Gene Snapshot "knot (kn) encodes a transcription factor required for somatic and alary muscle specification and embryonic head segmentation. In larvae, it is required for wing disc patterning and plays a key role in the lymph gland, both under normal conditions and under immune stress." FBgn0020767 Alliance "Predicted to enable protein kinase binding activity. Involved in negative regulation of ERK1 and ERK2 cascade. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic dorsal epidermis; eye photoreceptor cell; and ganglia. Human ortholog(s) of this gene implicated in Legius syndrome and Noonan syndrome. Orthologous to several human genes including SPRED2 (sprouty related EVH1 domain containing 2)." FBgn0033960 Alliance Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. Is expressed in embryonic brain and larval ventral nerve cord. FBgn0028689 FlyBase Gene Snapshot "Regulatory particle non-ATPase 6 (Rpn6) encodes a structural subunit of the 26S proteasome, located in the lid section of the 19S regulatory particle. In the 26S proteasome, it forms a bridge between the 19S regulatory and 20S core particles." FBgn0033958 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; embryonic head sensory system; embryonic/larval nervous system; ganglia; and sensory nervous system primordium. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). FBgn0020269 Alliance "Involved in regulation of myoblast fusion. Located in collagen-containing extracellular matrix. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval hypodermal muscle cell; ganglia; region of integument; and sensory nervous system primordium. Orthologous to human SPON2 (spondin 2)." FBgn0033954 Alliance Is expressed in spermatozoon. FBgn0033953 Alliance Is expressed in spermatozoon and testis. FBgn0033952 Alliance Predicted to be involved in inosine biosynthetic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). FBgn0033932 FlyBase Gene Snapshot "Diuretic hormone 44 receptor 1 (Dh44-R1) encodes a G-Protein Coupled Receptor of the Family B class of GPCRs (Secretin Receptor-like). It is involved in regulation of diuresis, sperm storage in females and circadian control of locomotion." FBgn0033933 Alliance Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D). FBgn0033935 UniProtKB "Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. (UniProtKB:Q9V719)" FBgn0033936 FlyBase Gene Snapshot Achilles (Achl) is a clock-controlled gene that is expressed in a rhythmic manner in the brain. It regulates wing development and expression of antimicrobial peptides. FBgn0050197 Alliance Predicted to enable peptidase inhibitor activity. Predicted to be located in extracellular region. FBgn0033943 Alliance Is expressed in embryonic head sensory system; embryonic ventral epidermis; sense organ; sensory cluster; and ventral sensory complex primordium. FBgn0050077 FlyBase Gene Snapshot "Biogenesis of lysosome-related organelles complex 1, subunit 1 (Blos1) encodes a subunit of the octameric complex BLOC-1. BLOC-1 is a cytosolic factor involved in membrane traffic that controls eye color, synaptic morphology, homeostatic synaptic plasticity, and synaptic vesicle recycling." FBgn0010638 FlyBase Gene Snapshot Sec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy. FBgn0033949 Alliance Predicted to enable L-gulonate 3-dehydrogenase activity. Predicted to be involved in fatty acid metabolic process. Is expressed in adult fat body. Orthologous to human CRYL1 (crystallin lambda 1). FBgn0033948 Alliance Predicted to enable rRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be active in cytoplasm and nucleolus. Is expressed in organism. Orthologous to human ZCCHC4 (zinc finger CCHC-type containing 4). FBgn0026427 FlyBase Gene Snapshot "Su(var)2-HP2 (Su(var)2-HP2) encodes a chromosomal protein that interacts with the product of Su(var)205 and is found most closely associated with centromeric heterochromatin, telomeres and the fourth chromosome. Lack of Su(var)2-HP2 can cause mitotic abnormalities and suppress position-effect variegation." FBgn0019938 UniProtKB DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). (UniProtKB:P91875) FBgn0010397 FlyBase Gene Snapshot "Lamin C (LamC) encodes a type V intermediate filament that is essential for development. It contributes to the shape and structural integrity of the nucleus and plays roles in genome integrity and gene regulation, through contacts made with chromatin." FBgn0033942 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including embryonic esophagus; embryonic head epidermis; embryonic tracheole; embryonic ventral epidermis; and epithelium." FBgn0013725 UniProtKB "Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Acts downstream of Notch signaling to specify the fate of the SOP (sensory organ precursor) cells and their progeny, probably via the sina-mediated proteasomal degradation of ttk. Its restricted pattern of expression, upon Notch and Ras signaling pathways, suggests that it acts as a key determinant in E3 complexes to trigger protein proteolysis in appropriate cells. (UniProtKB:Q27934)" FBgn0033934 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval muscle system; ganglia; and gonad." FBgn0033899 Alliance Predicted to be active in membrane. Is expressed in organism. Orthologous to human TMEM39A (transmembrane protein 39A) and TMEM39B (transmembrane protein 39B). FBgn0033901 UniProtKB "Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines (PubMed:12909620). Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer (By similarity). Plays a crucial role in Notch signaling (PubMed:12909620, PubMed:12917292, PubMed:17329366). Initial fucosylation of Notch/N by O-fut1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that can then extend the fucosylation on the Notch EGF repeats (PubMed:12909620). This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by Delta/Dl or Serrate/Ser (PubMed:12909620, PubMed:12917292). Also required for the transport of Notch/N to the early endosome (PubMed:17329366). (UniProtKB:Q9V6X7)" FBgn0033903 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head. Orthologous to several human genes including SLC25A35 (solute carrier family 25 member 35). FBgn0033904 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Predicted to be located in mitochondrial inner membrane. Orthologous to several human genes including SLC25A35 (solute carrier family 25 member 35). FBgn0033905 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head and organism. Orthologous to several human genes including SLC25A35 (solute carrier family 25 member 35). FBgn0033906 Alliance Involved in endoplasmic reticulum organization. Located in axon and endoplasmic reticulum. Is expressed in adult head; adult heart; and embryonic/larval salivary gland. Orthologous to human REEP5 (receptor accessory protein 5). FBgn0000289 FlyBase Gene Snapshot combgap (cg) encodes a DNA binding protein that can act as a repressor or activator of gene expression depending on context. It binds to Polycomb Response Elements and is necessary to recruit Polycomb protein complexes to some of them. FBgn0033913 Alliance "Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; anterior endoderm; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14) and SLC16A8 (solute carrier family 16 member 8)." FBgn0033916 FlyBase Gene Snapshot Ubiquitin specific protease 20/33 (Usp20-33) encodes a deubiquitinase involved in nervous system development. FBgn0033917 Alliance "Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle system; embryonic/larval somatic muscle cell; somatic muscle primordium; and visceral muscle primordium." FBgn0033918 Alliance "Predicted to enable ATPase activator activity. Predicted to be involved in cristae formation and protein import into mitochondrial matrix. Predicted to be located in mitochondrion and nucleus. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; mesoderm; and visceral mesoderm derivative. Orthologous to human DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11)." FBgn0027538 FlyBase Gene Snapshot "beta1,4-N-acetylgalactosaminyltransferase A (beta4GalNAcTA) encodes a acetylgalactosaminyltransferase involved in glycolipid biosynthesis. It contributes to the development of the neuromuscular junction." FBgn0033924 Alliance Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Orthologous to human SPATA20 (spermatogenesis associated 20). FBgn0033928 UniProtKB Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells. (UniProtKB:Q7JV70) FBgn0033929 FlyBase Gene Snapshot "Transcription factor B1 (Tfb1) encodes a subunit of the Transcription factor II H complex (TFIIH). TFIIH operates in RNA polymerase I and II-mediated transcription, DNA repair and cell cycle regulation." FBgn0050073 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0050074 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0050075 Alliance Predicted to enable Hsp90 protein binding activity. Predicted to be involved in piRNA processing and spermatogenesis. Predicted to be active in cytoplasm. FBgn0033931 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0050067 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0033926 UniProtKB "Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258). (UniProtKB:Q7K1U0)" FBgn0033921 Interactive Fly "functions as a core component that recruits Vasa (Vas) and Spindle-E (Spn-E) into nuage granules through distinct motifs, thereby assembling nuage and engaging precursors for further processing in the piRNA pathway" FBgn0033919 Alliance "Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic epipharynx; and gut section." FBgn0001220 Alliance "Predicted to enable several functions, including ATP hydrolysis activity; mitochondrial protein-transporting ATPase activity; and protein folding chaperone. Involved in autophagy of mitochondrion and positive regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9)." FBgn0033915 Alliance Predicted to enable protein serine/threonine kinase activity. Orthologous to human SNRK (SNF related kinase). FBgn0033912 Alliance "A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Part of cytosolic small ribosomal subunit. Is expressed in adult head and adult heart. Used to study brachycephaly, trichomegaly, and developmental delay. Human ortholog(s) of this gene implicated in brachycephaly, trichomegaly, and developmental delay. Orthologous to human RPS23 (ribosomal protein S23)." FBgn0005613 FlyBase Gene Snapshot Sox box protein 15 (Sox15) encodes a transcription factor that regulates cell proliferation and cell death in the wing disc. FBgn0033907 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 2. Orthologous to human MRPS16 (mitochondrial ribosomal protein S16). FBgn0033902 FlyBase Gene Snapshot "eukaryotic translation initiation factor 3 subunit m (eIF3m) encodes a non core component of the EIF3 translation initiation factor. The product of eIF3m functions during caspase mediated remodeling of the syncytial testis, where it interacts with the apoptosome." FBgn0033900 Alliance "Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial)." FBgn0040751 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be active in mitochondrion. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 9. Orthologous to human COA5 (cytochrome c oxidase assembly factor 5). FBgn0033897 FlyBase Gene Snapshot Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. FBgn0013770 UniProtKB Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion. (UniProtKB:Q95029) FBgn0033891 Alliance "Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5)." FBgn0002643 FlyBase Gene Snapshot "mastermind (mam) encodes a transcriptional coactivator that functions in the Notch signaling pathway. It regulates gene expression by interacting with the intracellular domain of the product of N, which is produced upon receptor activation." FBgn0033893 Alliance Predicted to enable acylphosphatase activity. Orthologous to human ACYP2 (acylphosphatase 2). FBgn0040752 FlyBase Gene Snapshot "Prosap (Prosap) encodes a member of SH3 and multiple ankyrin repeat domain (SHANK) family of genes that encode synaptic scaffolding proteins. It regulates synaptic growth and development, including the structure of the neuromuscular junction and synapses of the calyx, and olfactory acuity." FBgn0020620 FlyBase Gene Snapshot Related to the N terminus of tre oncogene (RN-tre) encodes a protein involved in border cell migration. FBgn0033890 Alliance Predicted to enable chromatin binding activity. Involved in DNA endoreduplication and preblastoderm mitotic cell cycle. Predicted to be active in nuclear replication fork. Is expressed in organism. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). FBgn0033889 Alliance Predicted to enable 5'-3' RNA helicase activity and RNA binding activity. Involved in dendrite morphogenesis. Predicted to be active in P granule and cytosol. Is expressed in adult head. FBgn0033887 FlyBase Gene Snapshot "Sulfotransferase 4 (St4) encodes one out of 4 sulfotransferases that catalyze the sulfonation of many proteins, lipids and glycosaminoglycans." FBgn0033886 UniProtKB May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome (By similarity). (UniProtKB:Q7K2G1) FBgn0033885 UniProtKB "Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor (PubMed:16139213, PubMed:16139214, PubMed:20457924). Does not play a role in methylglyoxal detoxification (By similarity). (UniProtKB:A1Z9J4)" FBgn0013733 FlyBase Gene Snapshot "short stop (shot) encodes a member of the spectraplakin family of large cytoskeletal linker molecules. It binds both actin and microtubules, as well as scaffold proteins, certain signalling factors and calcium. It plays developmental and maintenance roles in the nervous system, the epidermis, at muscle attachments, the foregut, the wing, tracheae and oocytes." FBgn0033883 UniProtKB "Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (PubMed:37653044). Required for proper morphology and bioenergetic functions of mitochondria (PubMed:37653044). Required for maintenance of neurons, including photoreceptor neurons (PubMed:37653044). (UniProtKB:Q9V6U9)" FBgn0033859 FlyBase Gene Snapshot "fandango (fand) encodes a subunit of the NTC/Prp19 complex, which is essential for efficient spliceosome activation. It regulates the efficiency of splicing of zygotic transcripts and their abundance. It is required for normal cellularization, tracheal cell migration, and epidermal morphogenesis in the embryo." FBgn0033860 Alliance Predicted to enable manganese ion binding activity. Involved in mesoderm development. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0000633 FlyBase Gene Snapshot CG17716 encodes a predicted secreted immunoglobulin domain protein expressed in the embryonic central nervous system. FBgn0033863 Alliance Is expressed in spermatozoon. FBgn0033867 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0033869 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head; embryonic epipharynx; embryonic foregut; embryonic hypopharynx; and organism. FBgn0033871 Alliance Is expressed in organism. FBgn0033872 Alliance "Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic central brain neurons; and ganglia." FBgn0033874 Alliance Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; larval foregut atrium; and organism. FBgn0033880 Alliance Predicted to be active in plasma membrane. FBgn0033879 Alliance "Predicted to enable 3-hydroxypropionyl-CoA dehydratase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; germline cell; and gut section. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1)." FBgn0033876 FlyBase Gene Snapshot Synaptogyrin (Syngr) encodes a synaptic vesicle protein implicated in vesicle endocytosis during the bulk endocytosis process. It is the sole Drosopohila homolog of the synaptophysin/synaptogryin synaptic vesicle family of proteins. FBgn0033873 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in adult head; embryonic Malpighian tubule; embryonic hindgut; and embryonic main segment of Malpighian tubule. FBgn0000662 UniProtKB "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:1695150, PubMed:27919077). M6A methylation is also required for neuronal functions (PubMed:27919077). Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b (PubMed:10101174). (UniProtKB:Q9Y091)" FBgn0033868 Alliance Predicted to enable manganese ion binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). FBgn0033865 Alliance Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cdc73/Paf1 complex. FBgn0033862 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in spermatozoon." FBgn0033861 Alliance Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. FBgn0041579 FlyBase Gene Snapshot Attacin-C (AttC) encodes an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria. FBgn0053470 FlyBase Gene Snapshot "Baramicin A1 (BaraA1), like its identical paralog BaraA2, encodes a polypeptide precursor that is cleaved at furin cleavage sites to give rise to antifungal peptides, and is regulated by the Toll signalling pathway. BaraA1 mutants are susceptible to fungal and Gram-positive bacterial infections and also show deficient recovery after neurotoxin injection." FBgn0011882 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011883 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011884 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011885 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0019928 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0050509 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0040477 FlyBase Gene Snapshot "centromere identifier (cid) encodes a centromere-specific histone H3 variant. The nucleosomes containing the product of cid function as an epigenetic mark for centromere identity, and initiate an assembly process that recruits additional centromere proteins (like the product of Cenp-C) as well as kinetochore proteins at the start of mitotic and meiotic divisions." FBgn0033845 FlyBase Gene Snapshot mars (mars) encodes a microtubule-associated protein that shuttles between the mitotic spindle and the nucleus. It is required for mitotic spindle attachment to the centrosome. FBgn0033846 FlyBase Gene Snapshot "Myb-interacting protein 120 (mip120) encodes the sequence-specific DNA-binding protein of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle." FBgn0024556 FlyBase Gene Snapshot mitochondrial translation elongation factor Tu 1 (mEFTu1) encodes a protein predicted to function within mitochondria to bring aminoacyl-tRNA to the ribosome during the elongation phase of mRNA translation. FBgn0033848 Alliance Is expressed in spermatozoon. FBgn0014877 UniProtKB "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). (UniProtKB:P48604)" FBgn0033855 Alliance "Located in vesicle. Is expressed in several structures, including anlage in statu nascendi; antennal primordium; central brain anlage in statu nascendi; glial cell; and head epidermis primordium." FBgn0033856 Alliance Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in NADH metabolic process; lactate catabolic process; and pyruvate metabolic process. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human LDHAL6A (lactate dehydrogenase A like 6A). FBgn0027581 Alliance "Predicted to be involved in regulation of cell cycle. Is expressed in several structures, including adult head; compartment boundary; embryonic/larval brain; embryonic/larval central nervous system; and embryonic/larval peripheral nervous system. Orthologous to human CABLES1 (Cdk5 and Abl enzyme substrate 1) and CABLES2 (Cdk5 and Abl enzyme substrate 2)." FBgn0053156 Alliance Predicted to enable NAD+ kinase activity. Predicted to be involved in NADP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in ring gland. Orthologous to human NADK (NAD kinase). FBgn0033853 Interactive Fly sustains lipogenesis by maintaining the pool of NADPH - NADPH production rescues the lipid storage defect in the fat body of NADK RNAi animals -NADK and fatty acid synthase 1 regulate mitochondrial mass and function by altering the levels of acetyl-CoA and fatty acids. FBgn0011896 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0004638 FlyBase Gene Snapshot "downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory)." FBgn0033844 Alliance Predicted to enable diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in endoplasmic reticulum. Is expressed in adult head and adult heart. Used to study retinal disease. Orthologous to several human genes including CHPT1 (choline phosphotransferase 1). FBgn0033842 FlyBase Gene Snapshot crowded by cid (cbc) encodes a polynucleotide 5'-hydroxyl-kinase required at the transition to meiosis in spermatogenesis. FBgn0000119 FlyBase Gene Snapshot "arrow (arr) encodes a type I trans-membrane protein and functions as an obligate co-receptor with the product of fz for the ligand encoded by wg in the canonical Wnt signaling pathway. The product of arr is involved in developmental patterning, cell survival and growth regulation." FBgn0050062 Alliance Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). FBgn0011881 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0260475 Alliance Predicted to enable N-acetylglucosamine-6-sulfatase activity. Predicted to be involved in glycosaminoglycan metabolic process. Is expressed in adult heart and organism. FBgn0033836 Alliance Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). FBgn0033834 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. FBgn0033830 Alliance Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). FBgn0033828 Alliance Predicted to enable zinc ion binding activity. FBgn0033792 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in organism." FBgn0020391 FlyBase Gene Snapshot Neurospecific receptor kinase (Nrk) encodes a receptor tyrosine kinase that is expressed in the developing nervous system and regulates axon pathfinding and rhabdomere elongation. It interacts genetically with Dys and Dg. FBgn0053138 FlyBase Gene Snapshot "1,4-Alpha-glucan branching enzyme (Agbe) encodes a putative enzyme that is predicted to transfer alpha-1,4-linked glucose units from the outer non-reducing end of a growing glycogen chain into an alpha-1,6 position of the same or neighbouring chain, thereby creating glycogen branches during glycogen biosynthesis." FBgn0027079 Alliance Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head; embryonic/larval salivary gland; and organism. Orthologous to human VARS1 (valyl-tRNA synthetase 1). FBgn0033806 FlyBase Gene Snapshot "FLICE-associated huge protein (FLASH) encodes a metazoan-specific protein that plays an essential role in 3' end processing of replication-dependent histone pre-mRNAs. It localizes to histone locus bodies, which are microscopically detectable nuclear foci that form in the vicinity of histone gene clusters." FBgn0033808 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human TMEM186 (transmembrane protein 186)." FBgn0040754 UniProtKB "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. (UniProtKB:Q7JVR7)" FBgn0011763 FlyBase Gene Snapshot DP transcription factor (Dp) encodes a member of the DREAM complex and the common subunit of the two Drosophila heterodimeric E2F transcription factors. It is regulated by the product of Rbf and the Cyclin dependent kinases and controls the transcription of genes necessary for cell cycle progression. FBgn0033813 FlyBase Gene Snapshot fates-shifted (fsd) encodes an F-box protein with a role in the gradient formation of the product of bcd and fatemap specification through targeting bcd protein for ubiquitination and degradation. FBgn0033815 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in adult head; adult nervous system; embryonic/larval brain; and embryonic/larval central nervous system. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0033817 FlyBase Gene Snapshot Glutathione S transferase E14 (GstE14) encodes an essential protein for ecdysone biosynthesis. It is thought to play a crucial role in regulating cholesterol intake and/or transport in the steroidogenic cells. FBgn0033827 Alliance Is expressed in embryonic proventriculus inner layer. FBgn0033819 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme and ciliary basal body. FBgn0033818 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme and ciliary basal body. FBgn0033816 UniProtKB Mitochondrial protein that may have a role in mitochondrial translation. (UniProtKB:A1Z9A8) FBgn0033814 Alliance "Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in protein folding in endoplasmic reticulum. Is active in Golgi apparatus and extracellular space. Is expressed in several structures, including adult head; embryonic anal pad; embryonic large intestine; epithelium; and gut section. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2)." FBgn0033812 FlyBase Gene Snapshot Peroxin 13 (Pex13) encodes a peroxisome protein important for sperm development. FBgn0043010 FlyBase Gene Snapshot "F-box synaptic protein (Fsn) encodes an F-box protein that forms a ubiquitin ligase complex with the E3 ligase and the Skp protein encoded by hiw and SkpA, respectively. Its key substrates are the products of wnd and Nmnat." FBgn0005654 FlyBase Gene Snapshot Origin recognition complex subunit 3 (Orc3) encodes a subunit of the origin recognition complex. It is involved in DNA replication initiation and border follicle cell migration regulation. FBgn0053182 FlyBase Gene Snapshot Lysine (K)-specific demethylase 4B (Kdm4B) encodes a histone demethylase that removes methyl groups from histone 3 lysines 9 and 36. It participates in DNA repair and transcription regulation. FBgn0033802 Alliance "Is expressed in several structures, including anlage in statu nascendi; antennal anlage; ganglia; head epidermis primordium; and sensory nervous system primordium." FBgn0033799 FlyBase Gene Snapshot "Glial Lazarillo (GLaz) encodes a lipid binding protein of the Lipocalin family, which are small extracellular proteins with a single-domain beta-barrel structure. It is expressed in subsets of central and peripheral glial cells and in hemocytes. It regulates longevity, stress resistance, and behavior." FBgn0020370 FlyBase Gene Snapshot tripeptidyl-peptidase II (TppII) encodes an exopeptidase that removes tripeptides from the free N-terminus of longer peptides. FBgn0033794 Alliance Is expressed in adult head and spermatozoon. Orthologous to human ARMC3 (armadillo repeat containing 3). FBgn0033793 Alliance Is expressed in embryonic brain and larval ventral nerve cord. FBgn0028963 FlyBase Gene Snapshot Odorant receptor 49b (Or49b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0000181 FlyBase Gene Snapshot "bicaudal (bic) encodes the beta subunit of the nascent polypeptide-associated complex. It regulates osk mRNA localization, which in turn specifies the anterior/posterior axis of the egg." FBgn0002069 FlyBase Gene Snapshot Aspartyl-tRNA synthetase (AspRS) is an essential gene that is predicted to encode an aspartate-tRNA ligase. It functions as a Sxl dosage-sensitive maternal modifier. FBgn0003975 FlyBase Gene Snapshot vestigial (vg) encodes a wing/haltere identity selector gene. It functions as a transcriptional activator when bound to the product of sd to direct wing specific gene expression and regulate cell proliferation. It also has a role in muscle specification. FBgn0033782 FlyBase Gene Snapshot sugarbabe (sug) encodes a transcription factor that regulates the expression of insulin-like peptides and genes involved in lipid and carbohydrate metabolism. It is a direct target of the sugar sensor encoded by Mondo and its expression is also promoted by the product of daw. FBgn0033785 FlyBase Gene Snapshot Scaffold protein containing ankyrin repeats and SAM domain (Sans) encodes a putative scaffolding protein containing three ankyrin repeats and a sterile alpha motif domain. FBgn0033787 Alliance Is expressed in adult head; anterior midgut primordium; embryonic proventriculus; embryonic/larval midgut; and posterior midgut primordium. FBgn0033791 FlyBase Gene Snapshot "Derailed 2 (Drl-2) is a member of the RYK gene family encoding a receptor tyrosine kinase that transduces Wnt5 signaling. It regulates salivary gland positioning, muscle attachment site selection and olfactory system development. The products of Drl-2 and drl can play both cooperative and opposing roles, depending on the cells where they are differentially expressed." FBgn0005624 FlyBase Gene Snapshot Posterior sex combs (Psc) was originally identified as a member of the Polycomb group of genes that regulate gene expression through epigenetic marks. FBgn0004512 FlyBase Gene Snapshot Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. FBgn0050487 Alliance Predicted to be involved in cellular response to hydrogen peroxide. FBgn0033784 FlyBase Gene Snapshot Squamous cell carcinoma-related oncogene 3 (SCCRO3) encodes a protein involved in the regulation of protein neddylation. FBgn0033783 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and plasma membrane. Orthologous to several human genes including RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase). FBgn0025692 Alliance Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process. Predicted to be active in organelle membrane. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). FBgn0033778 FlyBase Gene Snapshot "Beta-alanine transporter (Balat) is predicted to encode a carnitine transporter, which catalyzes the movement of acyl-carnitine across the inner mitochondrial membrane. It is essential for metabolism of long-chain fatty acids." FBgn0033777 Alliance Is expressed in organism. FBgn0050486 Alliance Involved in sexual reproduction. Located in extracellular space. Orthologous to human GLIPR1 (GLI pathogenesis related 1) and CRISP1 (cysteine rich secretory protein 1). FBgn0050488 Alliance "Involved in negative regulation of female receptivity, post-mating and sperm storage. Located in extracellular space. Is expressed in adult head." FBgn0033775 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V6H1) FBgn0011592 FlyBase Gene Snapshot "frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis." FBgn0033753 FlyBase Gene Snapshot "Cyp301a1 (Cyp301a1) encodes a member of the cytochrome P450 family, which have both mitochondrial and cytosolic roles in the detoxification of compounds." FBgn0003527 UniProtKB "Essential in the female germline for proper survival, sex determination and differentiation. Participates in the transcriptional activation of Otu. Does not regulate the expression of Ovo. (UniProtKB:P92189)" FBgn0033755 FlyBase Gene Snapshot Chloride channel-b (ClC-b) encodes a chloride transmembrane transporter involved in phagocytosis. FBgn0027356 FlyBase Gene Snapshot Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. FBgn0004435 FlyBase Gene Snapshot "G protein alpha q subunit (Galphaq) encodes an alpha subunit of a heterotrimeric G-protein that functions downstream of GPCR signaling. It contributes to neuronal development, olfaction, flight, learning and memory." FBgn0050054 Alliance Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in photoreceptor neurons. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q). FBgn0033756 Alliance Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating dopamine receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in labellum. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; autosomal dominant hypocalcemia 2; congestive heart failure; familial hypocalciuric hypercalcemia 2; and familial multiple nevi flammei. Orthologous to human GNA11 (G protein subunit alpha 11) and GNAQ (G protein subunit alpha q). FBgn0028683 UniProtKB "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity). (UniProtKB:Q9TVQ5)" FBgn0011604 UniProtKB "Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502). (UniProtKB:Q24368)" FBgn0033762 Alliance "Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in intracellular zinc ion homeostasis and zinc ion transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval midgut; germline cell; gonad; and pole plasm. Orthologous to human SLC30A9 (solute carrier family 30 member 9)." FBgn0033763 Alliance "Predicted to enable sulfuric ester hydrolase activity. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; hindgut proper primordium; posterior endoderm; and ring gland primordium. Orthologous to human ARSI (arylsulfatase family member I) and ARSJ (arylsulfatase family member J)." FBgn0033770 Alliance Involved in male meiotic nuclear division and negative regulation of transcription by RNA polymerase II. Part of chromatin. Is expressed in primary spermatocyte and testis. FBgn0026741 Alliance Predicted to enable 5S rRNA binding activity. Predicted to be involved in rRNA import into mitochondrion. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human MRPL18 (mitochondrial ribosomal protein L18). FBgn0020930 FlyBase Gene Snapshot Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. FBgn0033774 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head; dorsal sensory complex primordium; dorsal sensory complex proper primordium; and posterior spiracle primordium. Orthologous to human CPA5 (carboxypeptidase A5). FBgn0003326 FlyBase Gene Snapshot scabrous (sca) encodes a secreted glycoprotein with partial homology to fibrinogen and its relatives. It is a transcriptional target of proneural bHLH proteins and a useful marker for proneural regions and cells. It contributes to neural patterning and interacts with the Notch pathway. FBgn0011227 UniProtKB "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. (UniProtKB:Q9XY35)" FBgn0026619 FlyBase Gene Snapshot Tafazzin (Taz) encodes a mitochondrial phospholipid-lysophospholipid transacylase that exchange acyl groups between cardiolipin molecules and other phospholipids. It plays a critical role in maintaining a normal cardiolipin composition required for optimal mitochondrial function. FBgn0033773 FlyBase Gene Snapshot Mos oncogene (Mos) encodes a kinase that activates the MAPK cascade during oogenesis. FBgn0033769 Alliance Is expressed in adult head; adult heart; and wing disc. Orthologous to human SDR39U1 (short chain dehydrogenase/reductase family 39U member 1). FBgn0050052 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. Is expressed in labellar taste bristle and labellum. FBgn0050053 Alliance Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. FBgn0033766 UniProtKB "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus. (UniProtKB:A0A0B4K859)" FBgn0033761 Alliance Predicted to enable methylglutaconyl-CoA hydratase activity. Involved in cold acclimation. Predicted to be active in mitochondrion. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to several human genes including AUH (AU RNA binding methylglutaconyl-CoA hydratase). FBgn0033760 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in vacuolar membrane. Is expressed in adult abdomen; adult head; adult thorax; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). FBgn0033757 Alliance Involved in oocyte maturation. Located in cytoplasm. Part of GID complex. Is expressed in organism. Orthologous to human MKLN1 (muskelin 1). FBgn0022764 FlyBase Gene Snapshot "Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation." FBgn0033754 FlyBase Gene Snapshot "Adenylate kinase 6 (Ak6) encodes a protein that works as both adenylate kinase and ATPase. It is involved in the p53 and NF-kappaB pathways. The functions of the product of Ak6 include the regulation of Cajal body assembly, histone transcription, 18SrRNA rRNA processing, cell growth and survival." FBgn0033710 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Predicted to be active in extracellular matrix. Is expressed in eye and photoreceptor neurons. Orthologous to human SPON1 (spondin 1). FBgn0050203 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. Orthologous to human SPON1 (spondin 1). FBgn0050046 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. Orthologous to human SPON1 (spondin 1). FBgn0033715 Alliance Is expressed in organism. FBgn0011878 Alliance Predicted to enable CAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033716 Alliance "Enables cysteine-type deNEDDylase activity. Involved in positive regulation of apoptotic process and protein deneddylation. Is expressed in adult head. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific)." FBgn0050047 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head and organism. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0050049 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0050043 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic large intestine; garland cell primordium; organism; and plasmatocyte primordium. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0053012 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0033720 Alliance Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic Malpighian tubule and embryonic/larval midgut. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). FBgn0033721 Alliance Is expressed in embryonic/larval salivary gland; embryonic/larval salivary gland body; and salivary gland body primordium. FBgn0050045 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head. FBgn0050042 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033724 Alliance Predicted to be involved in regulation of cholinergic synaptic transmission and sleep. FBgn0033725 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in extracellular region. Is expressed in several structures, including dorsal ectoderm anlage; embryonic foregut sensory structure; embryonic/larval fat body; gnathal primordium; and larval foregut atrium." FBgn0033727 FlyBase Gene Snapshot Odorant receptor 49a (Or49a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0033728 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; adult heart; embryonic head epidermis; embryonic salivary gland duct; and gut section." FBgn0033729 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033730 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head and eye. FBgn0050050 Alliance Is expressed in photoreceptor neurons. FBgn0033731 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033734 Alliance "Predicted to enable ATP hydrolysis activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrion organization. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human AFG1L (AFG1 like ATPase)." FBgn0033735 Alliance "Predicted to enable deoxyribose-phosphate aldolase activity. Predicted to be involved in carbohydrate catabolic process and deoxyribonucleotide catabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval fat body; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human DERA (deoxyribose-phosphate aldolase)." FBgn0050051 Alliance Involved in response to starvation. Predicted to be active in nuclear membrane. Used to study abdominal obesity-metabolic syndrome 1; obesity; and type 2 diabetes mellitus. Orthologous to human TMEM18 (transmembrane protein 18). FBgn0010238 FlyBase Gene Snapshot Lachesin (Lac) encodes a cell surface protein that belongs to the Ig superfamily. It is required for the proper ultrastructural organisation of septate junctions. Lac is required for tracheal system morphogenesis and for muscle contractions associated with peristalsis. FBgn0033741 Alliance "Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in maturation of LSU-rRNA and rRNA base methylation. Predicted to be active in nucleolus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human NOP2 (NOP2 nucleolar protein)." FBgn0033742 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0033744 FlyBase Gene Snapshot "Diuretic hormone 44 receptor 2 (Dh44-R2) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathways, hormone-mediated signaling pathways, and response to salt stress." FBgn0050044 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0033750 Alliance Is expressed in organism. FBgn0033752 Alliance Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of signal transduction and regulation of transcription elongation by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11). FBgn0033751 Alliance "Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle system; ganglia; and gut section." FBgn0033749 FlyBase Gene Snapshot achintya (achi) encodes a homeodomain transcription factor (TGIF subclass) that is required along with homeodomain protein encoded by vis for meiotic division in spermatogenesis. FBgn0033748 FlyBase Gene Snapshot vismay (vis) encodes a transcription factor that contributes to spermatogenesis. FBgn0045063 UniProtKB Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing. (UniProtKB:Q8WSF3) FBgn0033740 UniProtKB "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). (UniProtKB:Q7K4B4)" FBgn0033738 Alliance Enables cysteine-type deubiquitinase activity. Involved in negative regulation of apoptotic process and negative regulation of proteolysis involved in protein catabolic process. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Orthologous to human USP35 (ubiquitin specific peptidase 35) and USP38 (ubiquitin specific peptidase 38). FBgn0033737 UniProtKB "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050). Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner (PubMed:17682050). Together with Nup58, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346). By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346). (UniProtKB:Q9V6B9)" FBgn0033733 Alliance Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in adult head. FBgn0033726 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033717 Alliance "Predicted to enable acylglycerol lipase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Located in cytoplasm and endomembrane system. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; epithelium; and visceral mesoderm derivative. Orthologous to human FAAH2 (fatty acid amide hydrolase 2)." FBgn0050251 Alliance Predicted to enable CAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050250 Alliance Predicted to enable CAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050249 Alliance Predicted to enable CAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033713 Alliance Predicted to be involved in intracellular protein transport. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi medial cisterna; Golgi trans cisterna; and membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 105. Orthologous to human HID1 (HID1 domain containing). FBgn0033708 Alliance Predicted to enable L-amino acid transmembrane transporter activity; amino acid:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; adult thorax; embryonic Malpighian tubule; and embryonic main segment of Malpighian tubule. FBgn0033677 Alliance Is expressed in embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and organism. Orthologous to human ARL6IP6 (ADP ribosylation factor like GTPase 6 interacting protein 6). FBgn0024732 FlyBase Gene Snapshot DNA fragmentation factor-related protein 1 (Drep1) encodes a protein that regulates apoptosis. FBgn0028407 FlyBase Gene Snapshot DNA fragmentation factor-related protein 3 (Drep3) encodes a CIDE domain containing protein that can interact with the proteins encoded by Drep2 and Drep4 via CIDE-CIDE interaction. FBgn0033680 Alliance Predicted to be active in Golgi apparatus. Is expressed in embryonic/larval corpus allatum. Orthologous to human SELENOH (selenoprotein H). FBgn0027495 Alliance Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm and nucleus. Is expressed in embryonic/larval central nervous system; embryonic/larval gut; embryonic/larval somatic muscle cell; midgut primordium; and procephalic segment. Orthologous to human SMYD4 (SET and MYND domain containing 4). FBgn0033686 FlyBase Gene Snapshot Hen1 methyltransferase (Hen1) encodes a methyltransferase that methylates the terminal 2' hydroxyl group of small interfering RNAs and Piwi-interacting RNAs. It probably protects the 3' ends of small RNAs from degradation. FBgn0033687 Alliance Predicted to be involved in microtubule-based process. Predicted to be part of dynein complex. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human DNAL4 (dynein axonemal light chain 4). FBgn0023167 FlyBase Gene Snapshot "Small ribonucleoprotein particle protein SmD3 (SmD3) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmB. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. The product of SmD3 also has a function in germline specification, as it is required for localization of the product of osk to the posterior pole of the oocyte." FBgn0010621 FlyBase Gene Snapshot "Chaperonin containing TCP1 subunit 5 (CCT5) encodes a component of the TCP-1 ring complex (TRiC) chaperonin. It is involved in myofibril organization maintenance, cardiac physiological rhythm and lifespan determination." FBgn0033692 FlyBase Gene Snapshot "washout (wash) encodes a Wiskott-Aldrich syndrome protein that polymerizes branched actin through activation of the Arp2/3 complex, as well as bundles and/or crosslinks actin and microtubules. It functions as a downstream effector of the product of Rho1 in a context dependent manner. It is involved in nuclear and cytoplasmic cytoskeleton related cellular processes, including ooplasmic streaming, endosome recycing, hemocyte migration, and global nuclear organization." FBgn0025454 UniProtKB Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones. (UniProtKB:Q9V674) FBgn0033697 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V676) FBgn0033705 Alliance Is expressed in chordotonal neurons and spermatogonium. Orthologous to human IQCD (IQ motif containing D). FBgn0033706 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase complex." FBgn0000253 FlyBase Gene Snapshot "Calmodulin (Cam) encodes a Calcium-binding messenger protein. It acts as a part of the calcium signal transduction pathway and interacts with various target proteins such as kinases or phosphatases. It is involved in actin filament-based movement, mitotic spinde assembly, axon guidance, DNA damage response, autophagy, cell death, sensory perception, and muscle homeostasis." FBgn0020377 Alliance Predicted to be involved in nervous system development. Predicted to be located in membrane. Is expressed in central brain primordium; organism; and ventral nerve cord primordium. FBgn0033699 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome and nucleolus. Colocalizes with nuclear chromosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPS11 (ribosomal protein S11). FBgn0033698 Alliance Predicted to enable molecular adaptor activity. Predicted to be involved in ERAD pathway. Predicted to be part of proteasome complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and spermatozoon. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). FBgn0033696 FlyBase Gene Snapshot "Cytochrome P450 6g2 (Cyp6g2) encodes the major P450 epoxidase responsible for juvenile hormone biosynthesis, and may be involved in the breakdown of synthetic insecticides." FBgn0000426 FlyBase Gene Snapshot "Small ribonucleoprotein particle protein SmF (SmF) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmE and SNRPG." FBgn0033691 UniProtKB Necessary for protein translocation in the endoplasmic reticulum. (UniProtKB:Q9V668) FBgn0014184 UniProtKB "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (By similarity). Required for cellular differentiation in neuronal and myogenic lineages during embryonic development (PubMed:8878684). (UniProtKB:P54361)" FBgn0033688 FlyBase Gene Snapshot "pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome." FBgn0027504 Alliance Predicted to enable protein serine/threonine kinase activity. Involved in epigenetic regulation of gene expression and larval somatic muscle development. Acts upstream of with a positive effect on cytoplasmic microtubule organization. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. FBgn0033685 FlyBase Gene Snapshot Organic solute carrier partner 1 (OSCP1) encodes a tumor suppressor protein that mediates transport of various organic solutes into cells. It controls the differentiation of cone and pigment cells of pupal retinae via EGFR signalling regulation. FBgn0026176 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Used to study candidiasis. Orthologous to human SKP1 (S-phase kinase associated protein 1). FBgn0033679 Alliance Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Predicted to be involved in steroid metabolic process. Located in plasma membrane. Is expressed in adult head; adult heart; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13. Orthologous to several human genes including BDH1 (3-hydroxybutyrate dehydrogenase 1); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and SDR9C7 (short chain dehydrogenase/reductase family 9C member 7). FBgn0004839 FlyBase Gene Snapshot "off-track (otk) encodes a protein that associates with the product of PlexA to receive a repulsive signal from the product of Sema1a contributing to axon guidance in the central nervous system and motor neurons. The product of otk is also associated with non-canonical Wnt signaling, opposing canonical Wnt signaling activation." FBgn0033653 Alliance Predicted to be involved in social behavior. Predicted to be located in cytoplasm. Orthologous to human GNB1L (G protein subunit beta 1 like). FBgn0033657 FlyBase Gene Snapshot "Silnoon (Sln) encodes a monocarboxylate transporter that mediates active transport of metabolic monocarboxylates such as butyrate and lactate. The product of Lkb1 induces apical trafficking of the product of Sln in polarized cells, which is crucial for triggering apoptosis induced by extracellular butyrate." FBgn0013756 FlyBase Gene Snapshot "Megator (Mgtor) encodes a nuclear pore protein that is found in the nuclear matrix surrounding the chromosomes at interphase. During mitosis Mgtor product dynamically reorganizes, together with other nuclear and cytoplasmic proteins (such as those encoded by Skel, Chro, east, and Asator), to form a gel-like spindle matrix embedding the microtubule spindle apparatus. Mgtor product is important for normal cell cycle progression, functioning as a spatial regulator of cell cycle factors." FBgn0015543 FlyBase Gene Snapshot C/D box small nucleolar RNA 16 (snoRNA:CD16) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1347 in 28SrRNA:CR45844. FBgn0033665 Alliance Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; amnioserosa; embryonic Malpighian tubule; embryonic proventriculus; and embryonic/larval salivary gland. Orthologous to human SLC39A11 (solute carrier family 39 member 11). FBgn0033668 FlyBase Gene Snapshot "expansion (exp) encodes an atypical Smad-like protein which regulates tube size in the trachea through receptor tyrosine kinase (RTK) pathways, as well as apical secretion pathways." FBgn0026573 FlyBase Gene Snapshot ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. FBgn0033673 Alliance Predicted to be involved in carbohydrate metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase); GK2 (glycerol kinase 2); and GK3 (glycerol kinase 3). FBgn0033672 FlyBase Gene Snapshot "rhomboid-7 (rho-7) encodes an intramembrane serine protease of the rhomboid family present in the inner membrane of mitochondria. It regulates mitochondrial fusion during spermatogenesis and muscle development. rho-7 genetically interacts with fog, Opa1 and Pink1." FBgn0011704 UniProtKB Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (UniProtKB:P48592) FBgn0053145 FlyBase Gene Snapshot "beta1,3-galactosyltransferase 1 (GalT1) encodes an enzyme involved in protein N-linked glycosylation." FBgn0050037 Alliance "Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Orthologous to several human genes including B3GALT1 (beta-1,3-galactosyltransferase 1) and B3GALT2 (beta-1,3-galactosyltransferase 2)." FBgn0050036 Alliance "Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Orthologous to several human genes including B3GALT1 (beta-1,3-galactosyltransferase 1)." FBgn0033669 UniProtKB "Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression. (UniProtKB:Q9V637)" FBgn0033667 FlyBase Gene Snapshot "rebuf (reb) and the related exp encode proteins that belong to the Smad/FHA superfamily and have interchangeable functions. Both are required for the process of chitin deposition, together with the chitin synthase encoded by kkv." FBgn0033663 Alliance "Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; epithelium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3)." FBgn0033661 Alliance "Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in ribosomal large subunit assembly and ribosomal large subunit export from nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleus. Is expressed in several structures, including adult fat body; embryonic/larval midgut primordium; embryonic/larval muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human MDN1 (midasin AAA ATPase 1)." FBgn0033659 FlyBase Gene Snapshot Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death. FBgn0033658 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head. FBgn0033656 Alliance "Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein intracellular domain proteolysis and regulation of response to endoplasmic reticulum stress. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in X-linked keratosis follicularis spinulosa decalvans; X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques; ichthyosis follicularis-alopecia-photophobia syndrome 1; and osteogenesis imperfecta type 19. Orthologous to human MBTPS2 (membrane bound transcription factor peptidase, site 2)." FBgn0033654 Alliance Enables DNA-binding transcription factor binding activity. Involved in compound eye development. Predicted to be active in nucleus. Is expressed in border follicle cell; dorsal pharyngeal muscle cell; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and embryonic/larval visceral muscle cell. Orthologous to human SOBP (sine oculis binding protein homolog). FBgn0033651 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in Golgi organization and protein secretion. Located in endoplasmic reticulum. Is expressed in gustatory receptor neuron of the epiphysis. FBgn0011915 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050035 FlyBase Gene Snapshot "Trehalose transporter 1 (Tret1) encodes a transmembrane protein that mediates the bidirectional transport of trehalose. It exports trehalose synthesized in the fat body into the hemolymph and imports it into other tissues that require a carbon source for energy production. It does not transport maltose, sucrose or lactose." FBgn0033644 FlyBase Gene Snapshot Trehalose transporter 1-like (Tret1l) encodes a transmembrane protein that appears to lack trehalose transporter activity. FBgn0040491 FlyBase Gene Snapshot Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. FBgn0062449 Alliance Predicted to enable polynucleotide 5'-phosphatase activity. Orthologous to human DUSP11 (dual specificity phosphatase 11). FBgn0033649 FlyBase Gene Snapshot "pyramus (pyr) encodes a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival." FBgn0033648 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis. FBgn0010516 FlyBase Gene Snapshot "walrus (wal) encodes a protein involved in the development of Malpighian tubules, gut and trachea." FBgn0033645 Alliance Predicted to be involved in cell morphogenesis. Predicted to be located in membrane. Is expressed in embryonic/larval dorsal vessel; embryonic/larval tracheal dorsal trunk; and embryonic/larval tracheal section. FBgn0044020 FlyBase Gene Snapshot "Regulator of cullins 2 (Roc2) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul5 and recruits ubiquitin-charged E2 to the CRL5 E3 ubiquitin ligase complex, which functions during oogenesis." FBgn0011916 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050254 Alliance Predicted to enable AGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033639 Alliance Involved in response to endoplasmic reticulum stress. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adult head and spermatozoon. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2) and FBXL20 (F-box and leucine rich repeat protein 20). FBgn0033638 UniProtKB "Transcription regulator that synchronizes transcriptional and translational programs to promote macrophage invasion of tissues. Required in macrophages for their early invasion into the extended germband. Induces transcriptional expression of metabolic enzymes as well as of the translational regulator pths/DDX47. With pths/DDX47, adjusts transcription and translation of a subset of OXPHOS genes to increase mitochondrial bioenergetics and allow macrophage tissue invasion. (UniProtKB:Q7JXG9)" FBgn0033636 FlyBase Gene Snapshot toutatis (tou) encodes a transcription factor that activates proneural expression via positive regulation of the product of pnr. It is involved in chromatin remodeling and nervous system development. FBgn0003396 FlyBase Gene Snapshot "schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites." FBgn0037084 Alliance "Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including retrograde transport, endosome to Golgi; synaptic vesicle docking; and vesicle fusion. Predicted to be located in plasma membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle membrane. Is expressed in embryonic brain; embryonic/larval nervous system; larval ventral nerve cord; and organism. Orthologous to several human genes including STX10 (syntaxin 10)." FBgn0033584 Alliance Predicted to enable polyamine oxidase activity. Is expressed in adult head and organism. Orthologous to human SMOX (spermine oxidase). FBgn0026386 FlyBase Gene Snapshot Odorant receptor 47a (Or47a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0033598 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033599 Alliance Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). FBgn0033602 Alliance "Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; haltere disc; and wing hinge." FBgn0041174 FlyBase Gene Snapshot von Hippel-Lindau (Vhl) encodes a protein that regulates morphogenesis of trachea and follicular epithelium via its scaffolding functions. It promotes proteosomal degradation of the hypoxia inducible factor encoded by sima during normoxia. It also promotes vesicle transport via stabilization of microtubules and the endocytic factor encoded by awd. FBgn0033608 Alliance "Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm." FBgn0050033 Alliance Is expressed in adult fat body. FBgn0033615 Alliance "Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1)." FBgn0033616 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism. FBgn0003382 FlyBase Gene Snapshot shavenoid (sha) encodes a novel protein that appears to promote trichome (hair) formation. sha mutations interact synergistically with mutations in fz/stan pathway genes. FBgn0043470 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult midgut enterocyte; embryonic midgut chamber; and embryonic/larval midgut. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0010357 FlyBase Gene Snapshot "betaTrypsin (betaTry) encodes a putative digestive enzyme with predicted serine-type endopeptidase activity. betaTry is highly expressed and enriched in the midgut, an organ involved in digestion." FBgn0050031 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in gastric caecum. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0010358 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in cytosol. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0015001 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0024188 UniProtKB "N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates (PubMed:14653991). Required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (PubMed:14653991, PubMed:18801358, PubMed:27996020). Required for the interaction between Scc1/vtd and SMC3, possibly by mediating N-terminal acetylation of Scc1/vtd (PubMed:27996020). (Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body. (UniProtKB:Q9NHD5)" FBgn0041241 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58961)" FBgn0033627 FlyBase Gene Snapshot "CG13204 encodes a protein predicted to be a transcriptional regulator. CG13204 overexpression can partially rescue hng1 loss of function, suggesting either epistasis or an overlaping function between hng1 and CG13204." FBgn0050257 Alliance Predicted to enable ACA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033635 Alliance "Enables water channel activity. Involved in water transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult head; dorsal appendage; epithelium; ganglia; and germline cell. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma; nephrogenic diabetes insipidus; and nephrogenic diabetes insipidus type 2. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)); AQP2 (aquaporin 2); and AQP5 (aquaporin 5)." FBgn0000581 FlyBase Gene Snapshot "Enhancer of Polycomb (E(Pc)) encodes a chromatin protein that functions as a suppressor of position-effect variegation. An unusual member of the Polycomb group; it does not exhibit homeotic transformations on its own, but rather enhances mutations in other Polycomb group genes. It forms part of the TIP60 histone acetyltransferase complex, which has been involved in many processes, including both transcriptional activation and repression." FBgn0050506 Alliance Predicted to enable ACA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0082585 Alliance "Is expressed in several structures, including adult tracheal system; anterior endoderm anlage; gut section; mesoderm; and visceral mesoderm derivative." FBgn0050022 Alliance Predicted to enable iron ion binding activity and sulfur dioxygenase activity. Predicted to be involved in glutathione metabolic process and hydrogen sulfide metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in ethylmalonic encephalopathy. Orthologous to human ETHE1 (ETHE1 persulfide dioxygenase). FBgn0033629 FlyBase Gene Snapshot Tetraspanin 47F (Tsp47F) encodes a member of the tetraspanin superfamily of integral membrane proteins that are involved in cell adhesion and signal transduction. FBgn0021795 Alliance "Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iy. Orthologous to human SSR4 (signal sequence receptor subunit 4)." FBgn0001276 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for female somatic sexual development. (UniProtKB:Q7KBL8)" FBgn0033624 Alliance "Predicted to enable death domain binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of DNA-templated transcription; and negative regulation of autophagy. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; embryonic proventriculus inner layer; and gut section. Orthologous to human DAP (death associated protein)." FBgn0011987 Alliance Predicted to enable UGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033623 Alliance Predicted to enable protein homodimerization activity. Predicted to be involved in cilium movement. Predicted to be part of outer dynein arm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 17. Orthologous to human CCDC103 (coiled-coil domain containing 103). FBgn0050025 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0010359 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic/larval digestive system. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0010425 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS53 (serine protease 53). FBgn0003863 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head and embryonic/larval digestive system. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0011555 FlyBase Gene Snapshot "thetaTrypsin (thetaTry) encodes a putative digestive enzyme with predicted serine-type endopeptidase activity. thetaTry is highly expressed and enriched in the midgut, an organ involved in digestion." FBgn0011554 FlyBase Gene Snapshot "etaTrypsin (etaTry) encodes a putative digestive enzyme with predicted serine-type endopeptidase activity. etaTry is highly expressed and enriched in the midgut, an organ involved in digestion." FBgn0011556 FlyBase Gene Snapshot zetaTrypsin (zetaTry) encodes a putative digestive enzyme with predicted serine-type endopeptidase activity. zetaTry is highly expressed and enriched in the midgut and hindgut. FBgn0043471 Alliance Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0026385 FlyBase Gene Snapshot Odorant receptor 47b (Or47b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0025373 FlyBase Gene Snapshot Farnesyl pyrophosphate synthase (Fpps) encodes a protein involved in germ cell migration. FBgn0033614 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0040763 Alliance Is expressed in spermatozoon. FBgn0015582 FlyBase Gene Snapshot defective in the avoidance of repellents (dare) encodes an enzyme associated with steroid hormone synthesis and required for normal olfactory behavior. Some mutants show widespread degeneration of adult nervous system. FBgn0033610 UniProtKB Probable microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilium axoneme. (UniProtKB:Q7JRP4) FBgn0033609 Alliance Enables SAM domain binding activity. Involved in positive regulation of ubiquitin-dependent protein catabolic process and regulation of protein stability. Predicted to be located in nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL6 (F-box and leucine rich repeat protein 6). FBgn0033607 UniProtKB Regulator of deubiquitinating complexes. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity). (UniProtKB:Q1LZ08) FBgn0033605 Alliance Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Orthologous to human TRAPPC2L (trafficking protein particle complex subunit 2L). FBgn0010423 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. Is expressed in adult head; adult heart; and organism. FBgn0033603 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033601 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033600 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033597 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0033593 FlyBase Gene Snapshot Listericin (Listericin) encodes an antibacterial protein whose induction is cooperatively regulated by the product of PGRP-LE and the JAK-STAT pathway. FBgn0033591 Alliance Is expressed in embryonic anal pad and embryonic ventral epidermis. FBgn0033590 Alliance Is expressed in embryonic epipharynx; embryonic hindgut; embryonic hypopharynx; and embryonic large intestine. FBgn0050021 FlyBase Gene Snapshot menage a trois (metro) encodes controls the expansion of larval neuromuscular junctions (NMJs) and the proper establishment of synaptic boutons. At NMJs Metro associates with the adaptor protein encoded by veli to stabilize the product of dlg1 in a trimeric scaffold complex that limits the size of active zones and glutamate receptor fields. FBgn0033582 Alliance Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human PLSCR4 (phospholipid scramblase 4). FBgn0033572 UniProtKB "Probable glutamate transporter which transports extracellular glutamate into the cells. Regulates the production of intracellular reactive oxygen species (ROS) probably by controlling the synthesis of antioxidant glutathione. By regulating ROS production in blood cells, required for maintaining bacteria phagocytosis following infection with S.aureus and possibly E.coli. (UniProtKB:Q4V5R4)" FBgn0033573 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. FBgn0033578 UniProtKB May be required for microtubule anchoring at the centrosome. Required for ciliogenesis (By similarity). (UniProtKB:A1Z8E9) FBgn0033580 Alliance Is expressed in adult head. FBgn0033581 Alliance "Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm." FBgn0033579 Alliance Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GPR139 (G protein-coupled receptor 139). FBgn0040765 UniProtKB "Probable transcription factor that is required for cell differentiation (PubMed:14527717, PubMed:24915236). Essential for proper separation of the sister chromatids during early nuclear division cycles in the syncytial pre-blastoderm embryo (PubMed:24915236). (UniProtKB:Q8MR37)" FBgn0033574 Alliance Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head and spermatozoon. Orthologous to human SERPINA7 (serpin family A member 7). FBgn0033542 Alliance Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head. FBgn0033544 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein monoubiquitination; and protein polyubiquitination. Predicted to be active in nucleus. Is expressed in adult fat body and eye. Orthologous to human UBE2W (ubiquitin conjugating enzyme E2 W). FBgn0050018 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval lymph gland. FBgn0033547 Alliance Predicted to be involved in nervous system development. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human TMEM223 (transmembrane protein 223). FBgn0033549 FlyBase Gene Snapshot Methyl methanesulfonate sensitivity 4 (mms4) encodes the non-catalytic subunit of the mus81-mms4 structure-selective endonuclease that functions in DNA repair. FBgn0033551 Alliance Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Is expressed in adult head and organism. Orthologous to human DESI2 (desumoylating isopeptidase 2). FBgn0029134 FlyBase Gene Snapshot Proteasome beta5 subunit (Prosbeta5) encodes an endopeptidase subunit of the of the 26S proteasome. FBgn0033555 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a)." FBgn0033557 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in spermatozoon. Orthologous to human PWP2 (PWP2 small subunit processome component)." FBgn0050020 Alliance Enables DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in organism. FBgn0033569 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism." FBgn0033571 Alliance "Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase II; and transcription elongation by RNA polymerase I. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; ganglia; gut section; and mesoderm. Orthologous to human POLR2E (RNA polymerase II, I and III subunit E)." FBgn0033570 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 33. Orthologous to human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6)." FBgn0017414 Alliance Predicted to enable DNA binding activity. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B); TIGD4 (tigger transposable element derived 4); and TIGD6 (tigger transposable element derived 6). FBgn0010356 FlyBase Gene Snapshot TBP-associated factor 5 (Taf5) encodes a protein that forms part of the multisubunit basal transcription factor TFIID and it may be important for its assembly or stability. FBgn0050016 Alliance Predicted to enable hydroxyisourate hydrolase activity. Predicted to be involved in purine nucleobase metabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). FBgn0050015 Alliance "Is expressed in several structures, including adult heart; cell body rind of adult optic lobe; embryonic/larval central nervous system; embryonic/larval posterior midgut; and eye disc." FBgn0027525 FlyBase Gene Snapshot "LTV1 ribosome biogenesis factor (LTV1) encodes a protein involved in pre-rRNA processing that is required for the proper biogenesis of the 40S ribosome. LTV1 product is a direct transcriptional target of Myc, thus it is critical for cell growth and survival." FBgn0033558 Interactive Fly "taste receptor that detects the basic pH of food - a high-pH-gated chloride channel and is specifically expressed in a subset of gustatory receptor neurons - in response to OH- stimuli, Alka is induced to adopt an open conformation, which leads to the flow of intracellular Cl- out of neuron" FBgn0033556 UniProtKB Involved in pre-mRNA splicing as component of the spliceosome. (UniProtKB:Q9V5Q4) FBgn0033554 FlyBase Gene Snapshot "Lsm10 (Lsm10) encodes a core component of the U7 snRNP complex, which functions in 3' end processing of the non-polyadenylated, replication-dependent histone mRNAs. The product of Lsm10 is part of the heptameric Sm ring complex that binds directly to U7 snRNA. It replaces the protein encoded by SmD1 in the canonical heptameric Sm protein ring that binds spliceosomal snRNAs." FBgn0033550 Alliance Is expressed in organism. Orthologous to several human genes including TMEM170A (transmembrane protein 170A). FBgn0033548 UniProtKB "Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (UniProtKB:Q9V5P6)" FBgn0027499 FlyBase Gene Snapshot windei (wde) encodes a chromatin-associated protein that functions as an essential cofactor and binding partner for the methyl transferase encoded by egg. It also binds to the chromosome 4-specific protein encoded by Pof. wde product is required for survival of female germ line cells. FBgn0053144 Alliance "Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic proventriculus; embryonic/larval muscle system; somatic muscle primordium; trunk mesoderm; and visceral mesoderm derivative. Orthologous to human RNF144A (ring finger protein 144A) and RNF144B (ring finger protein 144B)." FBgn0024956 FlyBase Gene Snapshot Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7 FBgn0033543 Alliance Predicted to enable D-amino-acid oxidase activity. Predicted to be involved in D-amino acid catabolic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic midgut chamber; embryonic proventriculus; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including DAO (D-amino acid oxidase). FBgn0005586 FlyBase Gene Snapshot "Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction." FBgn0033518 FlyBase Gene Snapshot Peroxiredoxin 6c (Prx6c) encodes a peroxidase involved in hydrogen peroxide catabolism. FBgn0053474 Alliance Predicted to be involved in peroxisome fission. Predicted to be active in peroxisomal membrane. Orthologous to human PEX11G (peroxisomal biogenesis factor 11 gamma). FBgn0033520 Alliance Enables peroxiredoxin activity. Involved in hydrogen peroxide catabolic process. Located in cytosol. Is expressed in adult head and organism. Orthologous to human PRDX6 (peroxiredoxin 6). FBgn0001122 FlyBase Gene Snapshot "G protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception." FBgn0033527 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of catalytic step 2 spliceosome. Is expressed in organism. Orthologous to human PPIL3 (peptidylprolyl isomerase like 3). FBgn0033529 Alliance "Predicted to enable calcium ion binding activity. Acts upstream of with a positive effect on retrograde trans-synaptic signaling. Is active in postsynaptic cytosol. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Orthologous to human PEF1 (penta-EF-hand domain containing 1)." FBgn0033528 FlyBase Gene Snapshot "translin (trsn) encodes a protein that, together with the product of Trax, forms the Trsn/Trax complex, a ribonuclease that facilitates RNA-induced silencing complex (RISC) activation and has been implicated in many different processes, including starvation-induced sleep suppression." FBgn0033526 FlyBase Gene Snapshot "Chromatin assembly factor 1, p105 subunit (Caf1-105) encodes one of the three subunits of Drosophila chromatin assembly factor 1 (CAF-1). It binds to histones and contributes to heterochromatin formation and maintenance, chromatin assembly, and developmental signal transduction such the Notch signaling pathway." FBgn0033524 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V5L3) FBgn0033523 UniProtKB "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (UniProtKB:A1Z897)" FBgn0033521 Alliance Predicted to enable thioredoxin peroxidase activity. Involved in mesoderm development. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be active in cytosol and mitochondrion. Is expressed in organism. Orthologous to human PRDX6 (peroxiredoxin 6). FBgn0033519 Alliance Involved in copper ion homeostasis. Predicted to be active in mitochondrion. Is expressed in embryonic/larval hindgut; embryonic/larval midgut; and organism. Orthologous to several human genes including HIGD1B (HIG1 hypoxia inducible domain family member 1B) and HIGD1C (HIG1 hypoxia inducible domain family member 1C). FBgn0033515 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neurons; labellar taste bristle; proboscis; and tarsal segment. FBgn0033490 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). FBgn0026388 FlyBase Gene Snapshot Odorant receptor 46a (Or46a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0033491 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism." FBgn0005619 FlyBase Gene Snapshot Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission. FBgn0033500 Alliance Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity and glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in wound healing. Predicted to be located in Golgi cisterna membrane. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1) and CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2). FBgn0033501 Alliance "Is expressed in several structures, including embryonic head epidermis; embryonic head sensory system; embryonic maxillary sensory complex; sensory cluster; and sensory nervous system primordium." FBgn0033502 Alliance Predicted to enable UDP-galactosyltransferase activity. Predicted to be involved in N-glycan processing and glycosylation. Predicted to be active in cytoplasm. Is expressed in adult head and midline glial cell. FBgn0033504 FlyBase Gene Snapshot "CAP (CAP) encodes a protein that localizes to focal adhesions and associates with proteins that regulate cytoskeletal organization, including the product of Vinc. It regulates the assembly and function of two actin-rich structures: the larval muscle attachment site, and the fly chordotonal organs in the larval body wall and in the adult Johnston's organ." FBgn0033507 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and rRNA processing. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; and gut section. Orthologous to human LYAR (Ly1 antibody reactive)." FBgn0026403 UniProtKB "Cell adhesion glycoprotein which is widely distributed in basement membranes (PubMed:30260959, PubMed:30567930). Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks (PubMed:30260959, PubMed:30567930). Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity (PubMed:30567930). Not involved in assembly of the embryonic basement membrane (PubMed:30567930). (UniProtKB:A1Z877)" FBgn0033508 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0028426 FlyBase Gene Snapshot "Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing." FBgn0003660 FlyBase Gene Snapshot "Synaptobrevin (Syb) encodes a member of the soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor (SNARE) family, which mediates vesicle fusion. It is important for secretory granule maturation and for preventing early degradation of these granules." FBgn0000448 FlyBase Gene Snapshot "Hormone receptor 3 (Hr3) encodes a protein induced directly by 20-hydroxyecdysone as a delayed-early response. It is required for tracheal air filling and ventral nerve cord condensation in embryos, for developmental progression through early metamorphosis, and in the prothoracic gland for ecdysteroid biosynthesis." FBgn0033494 FlyBase Gene Snapshot KCNQ potassium channel (KCNQ) encodes a voltage-gated channel involved in cardiac muscle contraction. FBgn0033454 Alliance "Predicted to enable U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human TBL3 (transducin beta like 3)." FBgn0050010 Alliance Involved in wound healing. Orthologous to human C8orf82 (chromosome 8 open reading frame 82). FBgn0033457 UniProtKB Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif (UniProtKB:Q6NN40) FBgn0033458 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval hemocyte; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative." FBgn0033459 UniProtKB May be involved in transcriptional regulation. (UniProtKB:Q7JUR5) FBgn0050008 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; adult heart; and organism. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0000715 FlyBase Gene Snapshot "FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation." FBgn0033469 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0027619 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:Q7K550)" FBgn0033471 Alliance Is expressed in embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human WDR89 (WD repeat domain 89). FBgn0000606 FlyBase Gene Snapshot "even skipped (eve) encodes a homeobox-containing transcriptional repressor that acts in concert with co-repressors such as those enoded by gro and Gug. It represses pair-rule and segment polarity genes, contributing to anterior/posterior axis specification and mesoderm and central nervous system development." FBgn0033473 Alliance "Predicted to enable RNA methyltransferase activity. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1)." FBgn0033475 Alliance Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human ASCC1 (activating signal cointegrator 1 complex subunit 1). FBgn0040773 FlyBase Gene Snapshot Cytochrome c oxidase subunit 7C (COX7C) encodes a negative regulator of neuroblast proliferation. FBgn0033480 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit and mitochondrial small ribosomal subunit. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human MRPL42 (mitochondrial ribosomal protein L42). FBgn0033483 FlyBase Gene Snapshot "eiger (egr) encodes the TNF superfamily ligand that activates the intracellular JNK pathway through its receptor encoded by grnd or wgn. Its roles include cell death, tumor suppression, tumor promotion, growth regulation, host defense, pain sensitization, and nutrient response." FBgn0033484 Alliance Is expressed in adult head. FBgn0001291 FlyBase Gene Snapshot "Jun-related antigen (Jra) encodes a homologue of the mammalian transcription factor Jun and has pleiotropic roles in the CNS. Jra activity is regulated by many upstream enzymes, including bsk." FBgn0003071 FlyBase Gene Snapshot "Phosphofructokinase (Pfk) encodes an enzyme that catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate. It is involved in the first committed step of glycolysis." FBgn0033486 FlyBase Gene Snapshot dampened (dmpd) encodes a nuclear F-box protein that acts as a co-activator of the product of bcd in modulating the expression level of its target gene hb. FBgn0010531 FlyBase Gene Snapshot "Copper chaperone for superoxide dismutase (Ccs) encodes a protein required for the proper superoxide dismutase function of the product of Sod1. It is involved in determination of lifespan, oxidative stress, and cytosolic aconitase activity." FBgn0033485 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in nuclear-transcribed mRNA catabolic process; rRNA processing; and ribosomal large subunit biogenesis. Predicted to be part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and mesoderm. Orthologous to human MRTO4 (MRT4 homolog, ribosome maturation factor)." FBgn0033482 Alliance "Predicted to enable carbohydrate binding activity. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; embryonic/larval muscle system; and gut section. Orthologous to human NOMO1 (NODAL modulator 1); NOMO2 (NODAL modulator 2); and NOMO3 (NODAL modulator 3)." FBgn0013435 FlyBase Gene Snapshot Cdc2-related kinase (Cdc2rk) encodes a kinase that might be involved in cell cycle regulation. FBgn0033479 Alliance Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). FBgn0010385 FlyBase Gene Snapshot Defensin (Def) encodes an antibacterial peptide with activity against Gram-positive bacteria. It is induced in the fat body during the systemic immune response and is expressed in various epithelia. The expression of Def is regulated at the transcriptional level by both the immune deficiency and Toll pathways. FBgn0033476 FlyBase Gene Snapshot oysgedart (oys) encodes a lysophospholipid acyltransferase that is required redundantly with the product of nes for germ cell migration and spermatid individualization. FBgn0033474 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane and synaptic vesicle maturation. Located in plasma membrane. Is expressed in adult central nervous system; adult head; embryonic/larval brain; and organism. Orthologous to several human genes including ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2) and ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). FBgn0022382 UniProtKB "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (PubMed:10781603, PubMed:9196067). Mediates membrane association by binding to anchoring proteins, such as Akap200 (PubMed:12223401, PubMed:9196067). Might play an essential role in the regulation of neuronal activity in the brain (PubMed:10781603, PubMed:9196067). (UniProtKB:P81900)" FBgn0033468 Alliance Predicted to be active in Golgi apparatus. Is expressed in organism. Orthologous to human RABAC1 (Rab acceptor 1). FBgn0033467 Alliance Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human PDRG1 (p53 and DNA damage regulated 1). FBgn0011656 FlyBase Gene Snapshot "Myocyte enhancer factor 2 (Mef2) encodes a protein that belongs to the MADS-box family of transcription factors and is required for muscle development. It directly activates a large number of muscle protein genes. It also regulates gene expression in other tissues, including the fat body and neural tissue." FBgn0033464 Alliance "Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in several structures, including adult fat body; adult head; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis." FBgn0033463 Alliance Predicted to enable sterol binding activity. Predicted to be active in Golgi apparatus; cytosol; and membrane. Is expressed in adult head; wing hinge primordium; and wing pouch. Orthologous to human OSBPL9 (oxysterol binding protein like 9). FBgn0033460 Alliance "Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in adult head. Orthologous to several human genes including SEC24A (SEC24 homolog A, COPII coat complex component)." FBgn0027580 FlyBase Gene Snapshot Pyruvate carboxylase (Pcb) encodes a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to form oxaloacetate in the first step of gluconeogenesis. FBgn0050000 FlyBase Gene Snapshot Glutathione S transferase T1 (GstT1) encodes an enzyme involved in glutathione metabolic processes. FBgn0050005 FlyBase Gene Snapshot Glutathione S transferase T2 (GstT2) encodes an enzyme involved in glutathione metabolic processes. FBgn0011921 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0260474 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0033439 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in Malpighian tubule primordium. FBgn0005614 FlyBase Gene Snapshot transient receptor potential-like (trpl) encodes a non-selective plasma membrane cation channel with modest Ca[2+] permeability. It is highly eye-enriched and contributes to the electrical response to light in photoreceptors. FBgn0033443 Alliance Predicted to enable L-amino acid transmembrane transporter activity; amino acid:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in anterior-posterior subdivision of organism; embryonic frontal ganglion; embryonic head epidermis; embryonic proventriculus; and embryonic stomatogastric nervous system. FBgn0040092 FlyBase Gene Snapshot "lectin-46Cb (lectin-46Cb) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, is required for the binding of product of SP to sperm, and for maintenance of long-term post-mating responses." FBgn0040093 FlyBase Gene Snapshot "lectin-46Ca (lectin-46Ca) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, it binds to sperm in the seminal receptacle. It is required for the binding of the product of SP to sperm, and for maintenance of long-term post-mating responses." FBgn0033449 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; embryonic/larval midgut primordium; gut section; and head epidermis primordium." FBgn0033451 FlyBase Gene Snapshot "Mitochondrial amidoxime reducing component (Marc) encodes a protein predicted to be a molybdenum cofactor enzyme. mARC enzymes are believed to be moonlighting enzymes, with two independent reductase functions: the reduction of a broad range of N-hydroxylated compounds, often associated with cellular detoxification, and the reduction of nitrite to nitric oxide." FBgn0023180 FlyBase Gene Snapshot "Origin recognition complex subunit 6 (Orc6) encodes a subunit of the origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells. Orc6 product has an additional independent function in cytokinesis through the interaction with the septin protein encoded by pnut." FBgn0033450 FlyBase Gene Snapshot "Lsm11 (Lsm11) encodes one of the seven proteins that form a heptameric Sm ring in the U7 snRNP, which is a key factor involved in 3' end processing of histone pre-mRNAs. It interacts with the product of FLASH. The two interacting proteins form a biochemical platform that recruits a number of polyadenylation subunits to the U7 snRNP, including the products of Sym, Cpsf100, Cpsf73 and CstF64." FBgn0033448 Alliance "Involved in determination of adult lifespan. Is expressed in several structures, including adult head; embryonic antennal sense organ; embryonic/larval posterior spiracle; larval ventral midline glial cell; and ventral midline of embryo." FBgn0033447 UniProtKB "Cilium-specific protein with a role in cilium/flagellum formation (PubMed:21750193, PubMed:27646273). May be involved in transport of components into the growing cilium (PubMed:21750193). In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme (PubMed:27646273). (UniProtKB:A1Z7Z9)" FBgn0050001 Alliance Is expressed in dorsal sensory complex proper primordium; embryonic brain; and organism. FBgn0033446 Alliance "Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult head; embryonic/larval muscle cell; and synaptic neuropil domain." FBgn0027589 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). FBgn0033442 Alliance Part of translation repressor complex. FBgn0023143 FlyBase Gene Snapshot "Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth." FBgn0033438 FlyBase Gene Snapshot "Matrix metalloproteinase 2 (Mmp2) encodes a proteinase that cleaves proteins in the extracellular matrix. It contributes to remodeling the body plan during metamorphosis; matrix and tissue remodeling during axon fasciculation, dendritic reshaping, wound healing, and ovulation; and down-regulating follicle stem cell proliferation." FBgn0033437 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; anterior endoderm anlage; anterior midgut primordium; embryonic/larval midgut; and posterior midgut primordium. Orthologous to human TTPAL (alpha tocopherol transfer protein like). FBgn0016970 UniProtKB Vital for development. (UniProtKB:Q9V574) FBgn0041087 FlyBase Gene Snapshot "wunen-2 (wun2) encodes a lipid phosphate phosphatase, an enzyme with an active site predicted to face extracellularly. It is required for germ cell migration and survival, acting partially redundantly with its paralog wun." FBgn0033413 FlyBase Gene Snapshot preli-like (prel) encodes a mitochondrial protein in the PRELI/MSF1 family that contributes to the integrity of mitochondrial structures and the activity of respiratory chain complex IV. FBgn0017558 UniProtKB "Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. (UniProtKB:P91622)" FBgn0004360 UniProtKB Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. (UniProtKB:P28465) FBgn0033422 FlyBase Gene Snapshot Odorant receptor 45b (Or45b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0033423 Alliance "Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in adult head; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0033426 Alliance "Predicted to enable 5'-nucleotidase activity and single-stranded DNA binding activity. Predicted to be involved in DNA damage response. Predicted to be located in nucleus. Is expressed in several structures, including adult head; adult heart; embryonic/larval muscle cell; and embryonic/larval muscle system. Orthologous to human NT5DC2 (5'-nucleotidase domain containing 2) and NT5DC3 (5'-nucleotidase domain containing 3)." FBgn0033428 UniProtKB Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (UniProtKB:Q9V595) FBgn0033431 UniProtKB Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. (UniProtKB:Q8MR45) FBgn0010342 FlyBase Gene Snapshot "Microtubule-associated protein 60 (Map60) encodes a microtubule binding protein that, together with gamma-tubulin and the product of Cp190, is a component of a centrosomal complex that can interact with microtubules." FBgn0033434 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0050338 Alliance Orthologous to human RWDD2A (RWD domain containing 2A) and RWDD2B (RWD domain containing 2B). FBgn0050339 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0050340 Alliance Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. FBgn0033429 Alliance Orthologous to human TMEM234 (transmembrane protein 234). FBgn0033427 Alliance "Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval gut; embryonic/larval somatic muscle cell; midgut primordium; and procephalic segment. Orthologous to human SMYD4 (SET and MYND domain containing 4)." FBgn0029092 FlyBase Gene Snapshot ced-6 (ced-6) encodes an intracellular adaptor protein involved in signal transduction. It binds the engulfment receptor encoded by drpr and transmits a signal for the induction of the phagocytosis of apoptotic cells. FBgn0016078 FlyBase Gene Snapshot "wunen (wun) encodes a lipid phosphate phosphatase with 6 transmembrane domains and an active site that is predicted to face extracellularly. It is required for germ cell migration and survival, septate junction function in the tracheal system and for heart formation." FBgn0028473 UniProtKB "Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle (PubMed:24255106). May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs (PubMed:24255106). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539, PubMed:35413237). (UniProtKB:Q9V411)" FBgn0033408 Alliance Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be part of outer dynein arm. Predicted to be active in cytoplasm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). FBgn0011746 FlyBase Gene Snapshot anachronism (ana) encodes a secreted glycoprotein that is expressed in glia and at lower levels in neuroblasts. It suppresses neuroblast proliferation. FBgn0025709 Alliance Enables cyclic-di-GMP transmembrane transporter activity. Involved in positive regulation of cGAS/STING signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; gut section; and yolk nucleus. Orthologous to several human genes including SLC28A1 (solute carrier family 28 member 1) and SLC28A2 (solute carrier family 28 member 2). FBgn0033371 Alliance Predicted to enable nucleoside:sodium symporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; late elongation-stage spermatid; mid-late elongation-stage spermatid; and testis. Orthologous to human SLC28A1 (solute carrier family 28 member 1); SLC28A2 (solute carrier family 28 member 2); and SLC28A3 (solute carrier family 28 member 3). FBgn0010220 UniProtKB Probable ATP-binding RNA helicase. (UniProtKB:Q07886) FBgn0033376 Alliance Involved in nuclear-transcribed mRNA catabolic process. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human SKIC3 (SKI3 subunit of superkiller complex). FBgn0015838 FlyBase Gene Snapshot Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. FBgn0033378 UniProtKB "Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed:11691839). (UniProtKB:Q9V535)" FBgn0003612 FlyBase Gene Snapshot "Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination." FBgn0033381 Alliance Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in organism. FBgn0033382 Alliance "Predicted to enable acetylesterase activity and acylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Is expressed in adult head. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase)." FBgn0028955 Alliance "Is expressed in several structures, including anterior endoderm anlage; embryonic/larval midgut primordium; epithelium; gut section; and mesoderm." FBgn0050342 UniProtKB Required for pre-mRNA splicing. (UniProtKB:Q7JVL3) FBgn0050344 Alliance "Predicted to enable transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be active in membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval garland cell; and garland cell primordium. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3)." FBgn0050345 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). FBgn0033389 FlyBase Gene Snapshot Rad51 recombinase D (Rad51D) encodes a spn-A paralog involved in homologous recombination in the repair of double-strand breaks. It is likely important for regulating the product of spn-A. FBgn0015561 UniProtKB Plays a regulatory role in neural branching of the tracheae: segment-specific aspects of these neural branching patterns appear to be generated by homeotic regulation of expression. May have a role with oc/otd in the postembryonic development of the brain. (UniProtKB:Q4V5A3) FBgn0033395 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V557) FBgn0015037 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V558) FBgn0033397 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V559) FBgn0050343 Alliance Predicted to enable nucleic acid binding activity. Involved in tRNA processing. Is expressed in adult fat body. FBgn0033401 UniProtKB Required for normal Golgi function. (UniProtKB:Q9V564) FBgn0028408 FlyBase Gene Snapshot DNA fragmentation factor-related protein 2 (Drep2) encodes a protein involved in neuron death regulation. FBgn0033402 FlyBase Gene Snapshot "Myd88 (Myd88) encodes an adaptor protein involved in in the Toll pathway functioning downstream of the product of Tl and upstream of the product of tub. Toll pathway is a signaling cascade that plays a key role in various developmental and immune processes, notably embryonic dorsoventral patterning and regulation of antimicrobial peptides." FBgn0026326 FlyBase Gene Snapshot "Mitotic arrest-deficient 1 (Mad1) encodes a conserved, essential component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the product of mad2 and promotes the assembly of the products of mad2 and fzy into the mitotic checkpoint complex. During interphase, Mad1 is intranuclear, bound to the product of mad2, and associated primarily with the nuclear pore complex." FBgn0033400 Alliance Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human SAP30BP (SAP30 binding protein). FBgn0020621 FlyBase Gene Snapshot "Protein kinase N (Pkn) encodes a serine/threonine protein kinase activated by Rho family GTPases, especially those encoded by Rho1 and Rac1. When activated, the product of Pkn regulates the actin cytoskeleton during oogenesis, wound repair, and in morphogenetic events including dorsal closure and wing development." FBgn0033392 Alliance Predicted to enable UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. Predicted to be involved in N-glycan processing to lysosome and carbohydrate phosphorylation. Predicted to be active in Golgi membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in mucolipidosis II alpha/beta and mucolipidosis III alpha/beta. Orthologous to human GNPTAB (N-acetylglucosamine-1-phosphate transferase subunits alpha and beta). FBgn0033391 Alliance Predicted to enable FAD transmembrane transporter activity and folic acid transmembrane transporter activity. Predicted to be involved in folate import into mitochondrion. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic/larval posterior spiracle; midline primordium; and organism. Orthologous to human SLC25A32 (solute carrier family 25 member 32). FBgn0015477 FlyBase Gene Snapshot Receptor mediated endocytosis 8 (Rme-8) encodes a protein involved in the regulation of border follicle cell migration and the endocytosis of the receptor encoded by N. FBgn0033388 UniProtKB "Putative proton-coupled transporter that delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Likely transports anhydro-muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) such as tracheal toxin (TCT), common in Gram-negative bacteria. May transport TCT across the phagosome membrane for cytosolic recognition by PGRP-LE, triggering the activation of imd/Relish pathway and production of antimicrobial peptides (PubMed:28539433). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). (UniProtKB:A1Z7R6)" FBgn0033387 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). FBgn0027561 Alliance Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling; endocytosis; and regulation of Rab protein signal transduction. Predicted to be located in clathrin-coated vesicle. Predicted to be active in cytosol and intracellular membrane-bounded organelle. Is expressed in adult head and organism. Orthologous to human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C). FBgn0033379 UniProtKB Required for 60S pre-ribosomal subunits export to the cytoplasm. (UniProtKB:Q7KKH3) FBgn0033377 Alliance Predicted to enable phosphopentomutase activity. Predicted to be involved in purine ribonucleoside salvage. Is expressed in spermatozoon. Orthologous to human PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2 like 1). FBgn0033375 UniProtKB "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (UniProtKB:Q7JWW5)" FBgn0033374 Alliance Is expressed in gonad; organism; and primordial germ cell. FBgn0033373 Alliance "Predicted to enable NAD+ kinase activity. Predicted to be involved in NAD metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult brain; adult pars intercerebralis; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Orthologous to human NADK2 (NAD kinase 2, mitochondrial)." FBgn0024189 FlyBase Gene Snapshot "sticks and stones (sns) encodes a single-pass transmembrane protein of the immunoglobulin superfamily, which mediates cell-cell recognition and adhesion. The product of sns marks the fusion competent population of myoblasts. It also contributes to formation and function of the nephrocyte diaphragm and cell sorting within the developing ommatidia." FBgn0050350 Alliance Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Is expressed in spermatozoon. FBgn0011286 FlyBase Gene Snapshot Ryanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. FBgn0021825 FlyBase Gene Snapshot "Dynactin 2, p50 subunit (DCTN2-p50) encodes a subunit of the dynactin complex. Together with other members of the dynactin complex, the product of DCTN2-p50 is critical for most functions of the minus end-directed microtubule motor cytoplasmic dynein-1, including oocyte polarity, mRNA localization, centrosome localizations, spindle organization, endocytosis and axonal transport." FBgn0033339 FlyBase Gene Snapshot Secretory 31 (Sec31) encodes a protein involved in the innate immune response. FBgn0004921 FlyBase Gene Snapshot "G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation." FBgn0050349 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in several structures, including adult head; anal pad primordium; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Orthologous to human WDR43 (WD repeat domain 43)." FBgn0002552 FlyBase Gene Snapshot lines (lin) encodes a nuclear protein involved in developmental patterning and cell fate specification. The Odd-skipped family protein encoded by bowl binds to and destabilizes the product of lin in the nucleus. Converserly the Odd family protein encoded by drm stabilizes the product of bowl in the nucleus by outcompeting the binding of the product of lin to the product of bowl and localizing the product of lin to the cytoplasm. FBgn0033349 Alliance Predicted to enable GTPase activator activity. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Used to study candidiasis. Orthologous to several human genes including SMAP2 (small ArfGAP2). FBgn0033350 Alliance Predicted to be part of Hrd1p ubiquitin ligase complex. Is expressed in adult head; embryonic/larval salivary gland; and organism. Orthologous to human FAM8A1 (family with sequence similarity 8 member A1). FBgn0033352 UniProtKB "Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. (UniProtKB:A1Z7K9)" FBgn0033353 Alliance Involved in nervous system process. FBgn0033355 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; leukemia (multiple); osteonecrosis; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human TFPI (tissue factor pathway inhibitor) and TFPI2 (tissue factor pathway inhibitor 2)." FBgn0033357 FlyBase Gene Snapshot Translocase of outer membrane 7 (Tom7) encodes a putative mitochondrial protein that may act as a channel component of the TOM complex based on orthology with the human gene TOMM7. FBgn0011300 FlyBase Gene Snapshot "baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes." FBgn0033364 Alliance Predicted to be located in membrane. Is expressed in adult head. FBgn0033369 Alliance Orthologous to human LRRC34 (leucine rich repeat containing 34). FBgn0033368 Alliance Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in membrane. Is expressed in adult abdomen; adult head; and adult thorax. Orthologous to human SLC38A11 (solute carrier family 38 member 11). FBgn0033367 FlyBase Gene Snapshot Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. FBgn0033366 Alliance Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in amnioserosa; embryonic/larval crystal cell; and procrystal cell. FBgn0033365 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS22 (serine protease 22) and PRSS41 (serine protease 41). FBgn0033363 FlyBase Gene Snapshot CG13744 encodes a CLIP-domain-containing serine protease. FBgn0033362 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in dorsal sensory complex proper primordium; embryonic/larval posterior spiracle; and posterior spiracle primordium. FBgn0033356 Alliance "Part of super elongation complex. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval fat body; embryonic/larval muscle system; gut section; and posterior midgut primordium." FBgn0027607 Alliance "Predicted to be involved in Golgi organization. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in Dyggve-Melchior-Clausen disease; Smith-McCort dysplasia 1; and osteochondrodysplasia. Orthologous to human DYM (dymeclin)." FBgn0033354 UniProtKB Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting Fancd2 monoubiquitination by Fancl and participating in recruitment to DNA repair sites. (UniProtKB:A1Z7L1) FBgn0033351 FlyBase Gene Snapshot "aaRS-interacting multifunctional protein 1 (AIMP1) is predicted to encode one of 3 non-enzymatic factors that combine with eight aminoacyl-tRNA synthetases to form a 'multi-synthetase complex' (MSC). The functional significance of the MSC is unclear, but the non-enzymatic factors are thought to be responsive to diverse signal transduction pathways." FBgn0033348 FlyBase Gene Snapshot "Spitting Image (Spt) encodes an F-actin binding and stabilizing protein. Spt and Sry-alpha represent a novel clade of the Vinculin/alpha-Catenin superfamily. The product of Spt is maternally provided in early embryos, and it positively regulates F-actin levels during cellularization." FBgn0003074 FlyBase Gene Snapshot "Phosphoglucose isomerase (Pgi) encodes an enzyme that catalyzes the reversible conversion of glucose 6-phosphate to fructose 6-phosphate. It is involved in the second step of glycolysis, and the reverse reaction during gluconeogenesis." FBgn0033344 Alliance Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be part of cAMP-dependent protein kinase complex. Orthologous to human AKAP14 (A-kinase anchoring protein 14). FBgn0033341 Alliance Involved in DNA repair-dependent chromatin remodeling. Part of NuA4 histone acetyltransferase complex. Is expressed in organism. Used to study prostate cancer. Orthologous to human MRGBP (MRG domain binding protein). FBgn0027513 FlyBase Gene Snapshot "anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central ""cartwheel"" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts." FBgn0033337 Alliance "Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism and spermatogonium. Orthologous to human FBXL9P (F-box and leucine rich repeat protein, pseudogene)." FBgn0033304 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V4U9) FBgn0033307 Alliance Is expressed in adult head. FBgn0033313 Interactive Fly "G-protein coupled receptor - involved in the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons of the PNS - sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function" FBgn0022027 FlyBase Gene Snapshot "Vacuolar protein sorting 25 (Vps25) encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps25 also has a role in bcd RNA localization." FBgn0033316 UniProtKB Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (UniProtKB:Q9V4W1) FBgn0050354 Alliance "Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to human UQCRH (ubiquinol-cytochrome c reductase hinge protein) and UQCRHL (ubiquinol-cytochrome c reductase hinge protein like)." FBgn0011906 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0001285 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0033321 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic/larval fat body. FBgn0033323 Alliance Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). FBgn0043576 FlyBase Gene Snapshot Peptidoglycan recognition protein SC1a (PGRP-SC1a) encodes a secreted peptidoglycan recognition protein (PGRP) with amidase activity against peptidoglycans. FBgn0033327 FlyBase Gene Snapshot Peptidoglycan recognition protein SC1b (PGRP-SC1b) encodes a secreted peptidoglycan recognition protein (PGRP) with amidase activity against peptidoglycans. FBgn0043575 FlyBase Gene Snapshot "Peptidoglycan recognition protein SC2 (PGRP-SC2) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against peptidoglycans. It contributes to the down-regulation of the immune deficiency pathway, notably in the fat body during systemic bacterial infection." FBgn0005695 FlyBase Gene Snapshot "germ cell-less (gcl) encodes a conserved BTB (broad-complex, tramtrack, and bric-a-brac) protein that mediates transcriptional repression in the germline and the degradation of the receptor tyrosine kinase encoded by tor, which in turn allows germ cell formation." FBgn0050356 Alliance Located in nucleus. Is expressed in late elongation-stage spermatid and testis. FBgn0040777 Alliance Predicted to be located in membrane. Predicted to be active in lysosomal membrane. Is expressed in embryonic brain; embryonic/larval garland cell; larval ventral nerve cord; and organism. Orthologous to human LAPTM4A (lysosomal protein transmembrane 4 alpha) and LAPTM4B (lysosomal protein transmembrane 4 beta). FBgn0033326 Alliance Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). FBgn0033324 Alliance Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). FBgn0033322 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be located in cytoplasm. FBgn0033320 Alliance Predicted to be involved in proteolysis. Located in extracellular region. FBgn0050355 Alliance Is expressed in adult head. FBgn0033317 Alliance "Predicted to enable metal ion binding activity. Predicted to be involved in cytoplasmic translation. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval muscle cell; epithelial tube; gut section; and mesoderm. Orthologous to human ZC3H15 (zinc finger CCCH-type containing 15)." FBgn0033315 FlyBase Gene Snapshot "beta-1,3-Galactosyltransferase II (beta3GalTII) encodes a protein involved in the synthesis of a common linkage tetrasaccharide structure of heparan (HS) and chondroitin sulfates (CS). Its roles include regulation of several signaling pathways (Hh, Dpp, Wingless) mediated by HS and CS in development." FBgn0033312 Alliance Predicted to enable G protein-coupled receptor binding activity and chitin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in spermatozoon. Orthologous to several human genes including MFAP4 (microfibril associated protein 4). FBgn0033309 Alliance "Predicted to be involved in endoplasmic reticulum tubular network organization. Located in endomembrane system. Is expressed in adult head. Orthologous to human LNPK (lunapark, ER junction formation factor)." FBgn0033308 Alliance Predicted to be a structural constituent of cuticle. Is expressed in dorsal head epidermis and larval foregut atrium. FBgn0033302 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V4U7) FBgn0033301 Alliance Predicted to enable carbohydrate binding activity. Involved in defense response to virus. Predicted to be located in cell surface. FBgn0033287 Alliance Is expressed in spermatozoon. FBgn0028836 FlyBase Gene Snapshot COP9 signalosome subunit 7 (CSN7) encodes the subunit 7 of the COP9 signalosome (CSN) and is essential for the stability of the complex. The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. FBgn0002534 UniProtKB Component of the larval cuticle. (UniProtKB:P07188) FBgn0002535 UniProtKB Component of the larval cuticle. (UniProtKB:P07189) FBgn0014469 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q27606) FBgn0015034 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V4T5) FBgn0002569 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0033294 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0050359 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0050360 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0033297 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0050361 Alliance Enables G protein-coupled receptor activity. Involved in adult feeding behavior; phospholipase C-activating G protein-coupled receptor signaling pathway; and response to insecticide. Located in dendrite and plasma membrane. Is expressed in gustatory receptor neurons; labellum; labral sense organ neurons; and organism subdivision. Used to study congenital stationary night blindness 1B. FBgn0033296 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0002571 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0002570 Alliance Predicted to enable maltose alpha-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). FBgn0033292 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V4T3) FBgn0002533 UniProtKB Component of the larval cuticle. (UniProtKB:P07187) FBgn0002531 UniProtKB Component of the larval cuticle. (UniProtKB:P02839) FBgn0033289 Alliance Predicted to enable potassium channel regulator activity and transmembrane transporter activity. Involved in muscle contraction. Predicted to be active in plasma membrane and striated muscle dense body. Is expressed in adult head; embryonic somatic muscle cell; and embryonic/larval somatic muscle cell. Orthologous to human UNC93A (unc-93 homolog A). FBgn0033286 Alliance Is expressed in spermatozoon. FBgn0050362 Alliance "Is expressed in several structures, including embryonic head sensory system; embryonic labial sensory complex; gut section; male germline cell; and sense organ." FBgn0050363 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0050366 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0050364 Alliance Is expressed in elongation stage spermatid; primary spermatocyte; and spermatozoon. FBgn0050365 Alliance Is expressed in elongation stage spermatid and primary spermatocyte. FBgn0028563 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; amnioserosa; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A2 (solute carrier family 2 member 2). FBgn0028562 Alliance Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder (multiple); myelomeningocele; and obesity. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A4 (solute carrier family 2 member 4); and SLC2A5 (solute carrier family 2 member 5). FBgn0028561 Alliance Predicted to enable hexose transmembrane transporter activity. Involved in glucose homeostasis. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder (multiple); myelomeningocele; and obesity. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A4 (solute carrier family 2 member 4); and SLC2A5 (solute carrier family 2 member 5). FBgn0033257 Alliance "Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Involved in cellular response to dopamine; negative regulation of circadian sleep/wake cycle, sleep; and negative regulation of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic esophagus; embryonic proventriculus; embryonic proventriculus inner layer; embryonic/larval somatic muscle cell; and embryonic/larval visceral muscle cell. Used to study epilepsy; heart conduction disease; and heart disease. Human ortholog(s) of this gene implicated in migraine. Orthologous to several human genes including KCNK18 (potassium two pore domain channel subfamily K member 18)." FBgn0033259 Interactive Fly expressed in multidendritic neurons in the fly tongue (proboscis) - mechanically activated Ca2+ channel - confers the ability to discriminate particle sizes in food and uses this information to decide whether a food is appealing - required for humidity response in Drosophila olfactory sensory neurons FBgn0033261 FlyBase Gene Snapshot "under-developed (udd) encodes a protein that interacts with the products of TAF1B and TAF1C-like, and helps to regulate RNA Polymerase I dependent rRNA transcription." FBgn0033264 FlyBase Gene Snapshot Nucleoporin 50kD (Nup50) encodes an important protein for TGF-beta signal transduction by mediating the nuclear translocation of the product of Mad. FBgn0033266 FlyBase Gene Snapshot "Suppressor of Cytokine Signaling at 44A (Socs44A) encodes a protein that promotes the degradation of interacting proteins by recruiting Cullin/Elongin ubiquitin ligase complexes. It activity negatively regulates JAK/STAT signaling and positively impacts RTK signaling in a context specific manner, which can impact developmental patterning." FBgn0005648 FlyBase Gene Snapshot Pabp2 (Pabp2) encodes a nuclear poly(A) binding protein that is involved in both the cleavage and polyadenylation steps of the nuclear cleavage/polyadenylation reaction. Cytoplasmic protein encoded by Pabp2 acts to shorten the poly(A) tails of specific mRNAs in oocytes and syncytial blastoderm embryos. FBgn0050297 Alliance Predicted to enable AUU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0021995 Alliance "Predicted to enable RNA helicase activity. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human DDX27 (DEAD-box helicase 27)." FBgn0033273 FlyBase Gene Snapshot Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. FBgn0011659 Alliance Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1). FBgn0053087 Alliance "Predicted to enable low-density lipoprotein particle receptor activity. Involved in regulation of axon guidance. Located in dendrite. Is expressed in adult brain cell body rind; adult head; and spermatozoon. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); keratosis pilaris atrophicans; lung disease (multiple); myocardial infarction; and sciatic neuropathy. Orthologous to several human genes including LRP1B (LDL receptor related protein 1B)." FBgn0013726 FlyBase Gene Snapshot "peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Septin1 and Septin2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex." FBgn0033277 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0050371 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in antennal disc; leg disc; and spermatheca. FBgn0050375 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11 and microcytic anemia. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase); TMPRSS6 (transmembrane serine protease 6); and TMPRSS7 (transmembrane serine protease 7). FBgn0010109 UniProtKB "Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:1427077, PubMed:24618901, PubMed:28899667). In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH (PubMed:21262215, PubMed:22357926, PubMed:23056424, PubMed:24618901, PubMed:28899667). As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch (PubMed:21262215, PubMed:22357926, PubMed:23056424). In the developing larval and pupal brain, required for mushroom body differentiation (PubMed:22357926). Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho (PubMed:7651341, PubMed:8001118). (UniProtKB:Q26263)" FBgn0033275 Alliance Is expressed in salivary gland body primordium. FBgn0033274 UniProtKB "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (UniProtKB:Q4V5I9)" FBgn0050373 Alliance Is expressed in adult head; adult heart; embryonic Malpighian tubule; embryonic/larval midgut; and organism. Orthologous to human UQCC4 (ubiquinol-cytochrome c reductase complex assembly factor 4). FBgn0033272 Interactive Fly RagA-B forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome were TOR is activated by Rheb - regulation of cell growth - insulin pathway FBgn0033271 Alliance "Enables beta-1,3-galactosyltransferase activity. Involved in protein glycosylation. Located in Golgi medial cisterna. Is expressed in adult head; ejaculatory duct; gland; salivary gland body primordium; and testis. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1)." FBgn0010504 FlyBase Gene Snapshot "kermit (kermit) encodes a GIPC (GAIP interacting protein, C terminus) type protein. It interacts with the product of Gyc76C, facilitating neuron axon guidance in a process mediated by the product of PlexA. It also physically and genetically interacts with the product of jar during wing planar cell polarity establishment. It is required for locomotive activity and determination of lifespan." FBgn0033268 Alliance "Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; embryonic central brain neurons; embryonic/larval nervous system; and ganglia." FBgn0033260 FlyBase Gene Snapshot "Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome." FBgn0033258 Alliance Enables chromatin binding activity. Involved in male meiosis I. Located in nucleolus and nucleoplasm. Is expressed in embryonic brain; larval ventral nerve cord; and organism. FBgn0025469 UniProtKB Mediates both low-affinity uptake and efflux of sugar across the membrane. (UniProtKB:Q7JVE7) FBgn0021814 FlyBase Gene Snapshot "Vacuolar protein sorting 28 (Vps28) encodes a member of the ESCRT-I complex, which sorts certain endocytosed receptors for degradation via the multivesicular body." FBgn0033252 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human IKZF2 (IKAROS family zinc finger 2)." FBgn0033221 Alliance Predicted to be located in membrane. FBgn0002891 FlyBase Gene Snapshot DNA polymerase zeta subunit 1 (PolZ1) encodes a DNA polymerase zeta catalytic subunit. It acts as a translesion polymerase during the bypass of DNA damage and has roles in DNA double-strand break and interstrand crosslink repair. FBgn0003317 FlyBase Gene Snapshot "saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning." FBgn0033226 Alliance "Enables carboxylesterase activity and phospholipase activity. Involved in lipid storage. Located in lipid droplet; mitochondrion; and peroxisome. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval fat body; embryonic/larval midgut primordium; and mesoderm. Used to study obesity. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to several human genes including ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B)." FBgn0003082 FlyBase Gene Snapshot photorepair (phr) encodes a DNA photolyase apoenzyme that repairs UV-induced DNA damage using FAD as a cofactor and blue light as a co-substrate. FBgn0033229 Alliance Predicted to enable tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity. Orthologous to human TRMO (tRNA methyltransferase O). FBgn0040780 Alliance Predicted to enable Atg12 conjugating enzyme activity. Predicted to be involved in macroautophagy and protein modification process. Predicted to be active in phagophore assembly site. Orthologous to human ATG10 (autophagy related 10). FBgn0050377 Alliance Involved in copper ion homeostasis. Is expressed in organism and spermatozoon. FBgn0015509 UniProtKB "Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (PubMed:20392747). Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in the regulation of zip and ck function in scolopidial apical attachment (PubMed:27331610). May function by acting in a Ubr3-mediated pathway that negatively regulates the ubiquitination of zip, consequently affecting its interaction with ck (PubMed:27331610). (UniProtKB:Q24311)" FBgn0033234 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in several structures, including amnioserosa; anterior-posterior subdivision of organism; embryonic/larval salivary gland; fat body/gonad primordium; and plasmatocyte primordium. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4)." FBgn0026722 FlyBase Gene Snapshot drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. FBgn0050379 Alliance Predicted to enable calcium channel activity. Predicted to be involved in calcium ion transport. Predicted to be active in organelle membrane. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). FBgn0033238 FlyBase Gene Snapshot "ahuizotl (azot) encodes a calcium dependent protein that ensures the elimination of less fit cells. Fitness-based cell culling is used to maintain tissue health, delay aging, and extend lifespan. During development it also prevents malformations." FBgn0050378 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. Orthologous to human CABP4 (calcium binding protein 4). FBgn0033240 Alliance Predicted to enable methyltransferase activity. Is expressed in larval ventral nerve cord and organism. Orthologous to human METTL25B (methyltransferase like 25B). FBgn0027548 UniProtKB "RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs (PubMed:27919077, PubMed:29535189, PubMed:29555755). M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:29535189, PubMed:29555755). In the WMM complex, may act by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:26324914, PubMed:29535189, PubMed:29555755). M6A methylation is also required for neuronal functions (PubMed:27919077). Acts as a positive regulator of canonical Wg signaling during wing disk and eye development (PubMed:16547102, PubMed:18174108). (UniProtKB:Q7KMJ6)" FBgn0027054 FlyBase Gene Snapshot COP9 signalosome subunit 4 (CSN4) encodes the subunit 4 of the COP9 signalosome (CSN) and is essential for the stability of the complex. The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. FBgn0033247 FlyBase Gene Snapshot "Nucleoporin at 44A (Nup44A) encodes a nuclear pore protein involved in TORC1 signaling, autophagy and oogenesis." FBgn0013307 UniProtKB "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (UniProtKB:P40807)" FBgn0013308 UniProtKB "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (UniProtKB:P40808)" FBgn0033249 Alliance Is expressed in organism. FBgn0027788 FlyBase Gene Snapshot Hairy/E(spl)-related with YRPW motif (Hey) encodes a transcription factor involved in neuron fate determination. Hey expression is regulated by Notch signalling in the embryonic and larval central nervous system. FBgn0033248 FlyBase Gene Snapshot "Dicarboxylate carrier 3 (Dic3) encodes a protein of the inner mitochondrial membrane that belongs to a subfamily of mitochondrial dicarboxylate carriers. It transports only phosphate, sulphate, and thiosulphate but not dicarboxylates (like the canonical dicarboxylate carrier encoded by Dic1). The product of Dic3 is exclusively present in the pupal stage." FBgn0033246 FlyBase Gene Snapshot "Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity." FBgn0033244 Alliance "Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in early endosome to late endosome transport; lysosomal transport; and negative regulation of monoatomic ion transport. Predicted to be active in early endosome; late endosome; and plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic antennal sense organ; ganglia; and germline cell. Used to study polycythemia due to hypoxia. Orthologous to human PXK (PX domain containing serine/threonine kinase like)." FBgn0033243 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. FBgn0026361 FlyBase Gene Snapshot "Septin 5 (Septin5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Septin5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Septin2." FBgn0033241 Alliance "Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Located in vesicle. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; antennal primordium; and head epidermis primordium. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to several human genes including CPA5 (carboxypeptidase A5)." FBgn0033236 Alliance Is expressed in adult head and organism. FBgn0033235 Alliance "Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 2. Orthologous to human PMPCA (peptidase, mitochondrial processing subunit alpha)." FBgn0023171 FlyBase Gene Snapshot ribonuclease H1 (rnh1) encodes a RNA-DNA hybrid ribonuclease. FBgn0050381 Alliance Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human PIGX (phosphatidylinositol glycan anchor biosynthesis class X). FBgn0033233 FlyBase Gene Snapshot "Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing." FBgn0026393 FlyBase Gene Snapshot Odorant receptor 43b (Or43b) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0033232 Alliance Is expressed in adult head. FBgn0050382 Alliance "Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, alpha-subunit complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6)." FBgn0029093 FlyBase Gene Snapshot cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria. FBgn0033225 Alliance Predicted to enable protein-glycine ligase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut and organism. Orthologous to human TTLL12 (tubulin tyrosine ligase like 12). FBgn0033224 UniProtKB "Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. (UniProtKB:Q0E9G3)" FBgn0033187 Alliance Predicted to enable CP2 mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and spermatozoon. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)). FBgn0033190 Alliance "Predicted to enable oxidoreductase activity, acting on CH-OH group of donors. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase (FAD) complex. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2)." FBgn0033192 Alliance "Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase)." FBgn0033194 FlyBase Gene Snapshot Vacuolar protein sorting 13 (Vps13) encodes a protein located to endosomal membrane that is involved in protein homeostasis. FBgn0050491 Alliance "Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval salivary gland; and salivary gland body primordium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13)." FBgn0050495 Alliance Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to be involved in retinal metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). FBgn0033203 Alliance Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human RDH13 (retinol dehydrogenase 13). FBgn0033204 Alliance Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult fat body; adult head; gnathal primordium; larval foregut atrium; and yolk nucleus. Orthologous to human RDH13 (retinol dehydrogenase 13). FBgn0033205 Alliance Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in lipid droplet formation and retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). FBgn0033209 Alliance "Predicted to be involved in mitochondrial respirasome assembly. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2. Orthologous to human RAB5IF (RAB5 interacting factor)." FBgn0050493 UniProtKB "Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (UniProtKB:Q8MKN0)" FBgn0050496 Alliance "Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase inhibitor activity. Predicted to be involved in negative regulation of protein ubiquitination. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in arteriovenous malformation; glomangioma; and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein)." FBgn0033214 Alliance Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1); MOGAT2 (monoacylglycerol O-acyltransferase 2); and MOGAT3 (monoacylglycerol O-acyltransferase 3). FBgn0033215 Alliance "Predicted to enable diacylglycerol O-acyltransferase activity. Involved in lipid droplet organization. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; amnioserosa; plasmatocyte primordium; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1); MOGAT2 (monoacylglycerol O-acyltransferase 2); and MOGAT3 (monoacylglycerol O-acyltransferase 3)." FBgn0033216 Alliance Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT2 (monoacylglycerol O-acyltransferase 2). FBgn0015614 UniProtKB "Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase. (UniProtKB:Q24214)" FBgn0000337 FlyBase Gene Snapshot "cinnabar (cn) encodes the enzyme that synthesizes 3-hydroxykynurenine (3-HK) as part of the kynurenine pathway of tryptophan degradation. 3-HK is an intermediate product in the formation of ommochromes, the brown pigments in the fly eye, and thus cn loss of function mutant flies exhibit altered eye color. Several kynurenine pathway metabolites are neuroactive and have been linked to the pathogenesis of neurodegenerative disorders." FBgn0042135 Alliance Involved in response to oxidative stress and response to starvation. Is expressed in adult head. Used to study autosomal recessive spinocerebellar ataxia 27. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). FBgn0003733 FlyBase Gene Snapshot torso (tor) encodes a receptor required for the specification of both terminal regions of the early embryo and for ecdysone synthesis in the prothoracic gland at pupariation. FBgn0033212 FlyBase Gene Snapshot Leucine-rich repeat (LRR) encodes a protein that can negatively regulate NF-kappaB signaling. FBgn0033210 FlyBase Gene Snapshot "U2A (U2A) encodes a protein component of the U2 snRNP, which combines with other snRNPs on the pre-mRNA to assemble a spliceosome." FBgn0033208 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in embryonic hindgut; embryonic/larval midgut; hindgut proper primordium; and organism. Orthologous to human MRPL52 (mitochondrial ribosomal protein L52). FBgn0033206 Alliance Predicted to be part of dynactin complex. Is expressed in adult head and organism. Orthologous to human DCTN4 (dynactin subunit 4). FBgn0033202 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0033199 Alliance Enables peptidoglycan binding activity. Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in Golgi membrane. Is expressed in adult head. Orthologous to several human genes including LYSMD3 (LysM domain containing 3). FBgn0028687 FlyBase Gene Snapshot Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. FBgn0033196 Alliance Predicted to enable heme binding activity and heme transmembrane transporter activity. Involved in histamine uptake. Located in plasma membrane. Is expressed in adult brain; adult fat body; and adult head. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to several human genes including FLVCR1 (FLVCR choline and heme transporter 1). FBgn0004133 FlyBase Gene Snapshot blown fuse (blow) encodes a cytoplasmic protein required for myoblast fusion. It regulates actin cytoskeletal dynamics via modulating the stability of the WASp-Vrp1 complex. FBgn0004132 FlyBase Gene Snapshot "boca (boca) encodes an endoplasmic reticulum protein that is evolutionarily conserved. It is required for the intracellular trafficking of members of the low-density lipoprotein family of receptors, including the one encoded by arr. As such, boca mutants are compromised for a number of pathways including Wingless signaling." FBgn0050499 FlyBase Gene Snapshot Ribulose-5-phosphate-3-epimerase (Rpe) encodes an enzyme that catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. It is involved in the non-oxidative branch of the pentose phosphate pathway. FBgn0033191 UniProtKB "ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. (UniProtKB:Q7JWD3)" FBgn0033188 FlyBase Gene Snapshot Death resistor Adh domain containing target (Drat) encodes a member of the zinc-dependent ADH-like family that is an effector of ethanol-induced apoptosis. FBgn0033186 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0003174 FlyBase Gene Snapshot pawn (pwn) encodes a protein involved in chaeta morphogenesis. FBgn0033158 Alliance "Involved in imaginal disc fusion, thorax closure." FBgn0033160 UniProtKB RNA helicase involved in mRNA processing and antiviral innate immunity (By similarity). Acts as an activator of the p38 MAPK cascade (PubMed:24782566). (UniProtKB:Q7K3M5) FBgn0033164 Alliance Predicted to be located in extracellular space. FBgn0033165 Alliance Predicted to be located in extracellular space. FBgn0003460 FlyBase Gene Snapshot "sine oculis (so) encodes a homeobox-containing transcription factor that functions with the product of eya as a transcriptional co-activator. It contributes to both cell and tissue fate specification, promotion of cell proliferation and suppression of apoptosis." FBgn0033169 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and mesoderm. Orthologous to human NOP9 (NOP9 nucleolar protein)." FBgn0033174 Alliance Predicted to be active in cytoplasmic microtubule. Is expressed in adult head; gonad; and organism. Orthologous to human ENKD1 (enkurin domain containing 1). FBgn0033178 Alliance Predicted to be active in cytoplasm. Is expressed in adult head and organism. FBgn0033185 Alliance Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. FBgn0025185 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in nurse cell; oocyte; organism; and ovary." FBgn0033184 FlyBase Gene Snapshot "mitochondrial translation elongation factor Tu 2 (mEFTu2) encodes a protein predicted to function within mitochondria to bring aminoacyl-tRNA to the ribosome during the elongation phase of mRNA translation. Unlike the protein encoded by mEFTu1, mEFTu2 product is enriched in the testis, suggesting a testis-specific role for this factor." FBgn0015929 UniProtKB "Acts as a component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. Essential role in mitotic DNA replication but not in endoreplication. (UniProtKB:Q26454)" FBgn0033183 Alliance "Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Is expressed in several structures, including central brain primordium; dorsal ectoderm anlage; embryonic brain; posterior endoderm; and trunk mesoderm. Orthologous to several human genes including MIER1 (MIER1 transcriptional regulator)." FBgn0010548 FlyBase Gene Snapshot "Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor." FBgn0033179 FlyBase Gene Snapshot p47 (p47) encodes a protein involved in nuclear envelope reassembly and rhabdomere development. FBgn0033177 Alliance Predicted to be involved in protein exit from endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 49. Orthologous to human TECPR2 (tectonin beta-propeller repeat containing 2). FBgn0050502 Alliance Enables fatty acid alpha-hydroxylase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Used to study hereditary spastic paraplegia 35. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). FBgn0040513 UniProtKB "Atypical Ras-like protein that may act as a regulator of NF-kappa-B activity, possibly by preventing the degradation of NF-kappa-B inhibitor cactus. (UniProtKB:Q9V4L4)" FBgn0050503 Alliance Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Orthologous to human PLA2G3 (phospholipase A2 group III). FBgn0033167 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in spermatozoon. FBgn0033166 FlyBase Gene Snapshot ELL-associated factor (Eaf) encodes a protein interactor of the ELL homolog encoded by Su(Tpl). It increases the ability of the product of Su(Tpl) to enhance transcription elongation of RNA Polymerase II. FBgn0041243 UniProtKB "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (UniProtKB:Q9V4K2)" FBgn0000352 FlyBase Gene Snapshot costa (cos) encodes a kinesin-like protein and a key component in the Hedgehog (Hh) pathway that is involved in pattern formation and growth control. It forms a complex with the product of fu to restrict the activity of the Hh pathway transcription factor encoded by ci. FBgn0033159 UniProtKB "Cell surface receptor involved in guidance and targeting of growing nerve axons (PubMed:10892653). Required during Bolwig's organ differentiation for accurate and efficient targeting of photoreceptor neuron axons to their synaptic targets in the brain via the P2 intermediate target neuron (PubMed:10892653). Involved in isoneural self-avoidance during dendrite arborization but not in heteroneural recognition and repulsion during tiling by related neurons of the same class (PubMed:17482551). Involved in regulating axon bifurcation and divergent extension in the developing mushroom body (PubMed:11856530, PubMed:15339648). Essential for axon arborisation in ellipsoid body (PubMed:11856530, PubMed:15339648). Exhibits an extraordinary level of molecular diversity resulting from alternative splicing (PubMed:10892653). Isoforms differing in their ectodomain makeup show a high degree of functional redundancy while isoforms with different transmembrane domains are involved in different neuronal morphogenetic processes and are differentially targeted to dendrites or axons (PubMed:15339648). The vast majority of isoforms exhibit strong isoform-specific homophilic binding (PubMed:15339666, PubMed:17889655). Individual cells express a distinct randomly generated repertoire of isoforms (PubMed:14758360). Cell surfaces bearing identical repertoires of Dscam1 isoforms, such as those from the same cell, trigger recognition and avoidance (PubMed:17482551). A subset of isoforms is expressed in fat body cells and hemocytes, cells that are part of the insect immune response, and these isoforms are secreted into the hemolymph (PubMed:16109846). The secreted form comprising the ectodomain can bind to bacteria, such as Escherichia coli, and may act as an opsonin enhancing their phagocytosis by hemocytes (PubMed:16109846). (UniProtKB:Q0E9H9)" FBgn0033127 Alliance "Involved in determination of adult lifespan. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; ganglia; and gut section." FBgn0033128 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. FBgn0033129 Alliance Predicted to be located in membrane. Is expressed in embryonic ventral apodeme and embryonic ventral epidermis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). FBgn0033130 Alliance "Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal apodeme; embryonic dorsal epidermis; and embryonic ventral apodeme. Orthologous to human TSPAN3 (tetraspanin 3)." FBgn0033132 FlyBase Gene Snapshot Tetraspanin 42Ej (Tsp42Ej) encodes a lysosomal member protein required for the degradation of endocytosed rhodopsin. It prevents light-induced retinal degeneration. FBgn0033133 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0033134 Alliance "Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic esophagus; embryonic head epidermis; and embryonic/larval dorsal vessel. Orthologous to human TSPAN3 (tetraspanin 3)." FBgn0016032 UniProtKB Facilitates synapse formation. (UniProtKB:Q24188) FBgn0033135 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0033136 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0033139 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0033140 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. FBgn0024294 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Located in cytoplasm. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic salivary gland duct; epithelium; and salivary gland common duct primordium. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive nonsyndromic deafness 91; intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINB6 (serpin family B member 6)." FBgn0003090 FlyBase Gene Snapshot "prickle (pk) encodes a core component of the Frizzled-dependent planar polarity complex, which localises to cell junctions in developing epithelia, most likely via direct protein-protein interactions with the transmembrane proteins encoded by Vang and stan. pk product contributes to planar polarity defects in epithelia, as well as nervous system development." FBgn0033149 Alliance Is expressed in spermatozoon. FBgn0033153 Interactive Fly exhibits a genetic interaction with JNK pathway affecting egg asymmetry in the oocyte; induced by wounding in embryos FBgn0026602 Alliance Predicted to enable adenosine kinase activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in mesoderm anlage and organism. FBgn0026389 FlyBase Gene Snapshot "Odorant receptor 43a (Or43a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. It is sensitive to a number of volatile small molecule odorants including cyclohexanol, cyclohexanone, benzaldehyde, and benzyl alcohol." FBgn0002930 FlyBase Gene Snapshot necrotic (nec) encodes a hemolymphatic Serpin that negatively regulates a serine protease involved in the immune activation of the Toll pathway. It is thought to function at the level or upstream of the serine protease encoded by psh. FBgn0044011 Alliance Predicted to be active in extracellular space. Orthologous to human SERPINA11 (serpin family A member 11) and SERPINA2 (serpin family A member 2 (gene/pseudogene)). FBgn0015039 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V4I1) FBgn0015038 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V4I0) FBgn0050299 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0050298 Alliance Predicted to enable ACU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0033138 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0027558 FlyBase Gene Snapshot Polypeptide N-Acetylgalactosaminyltransferase 3 (Pgant3) encodes a member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family. It catalyzes the transfer of a GalNAc sugar onto the hydroxyl groups of serine and threonine in secreted or membrane-bound proteins. Pgant3 product modulates secretion of extracellular matrix proteins and influences integrin-mediated cell adhesion during development. FBgn0033137 Alliance Predicted to be located in membrane. FBgn0016126 Alliance Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be located in cytosol. Is expressed in adult head and eye. Orthologous to several human genes including CAMK1D (calcium/calmodulin dependent protein kinase ID). FBgn0040324 FlyBase Gene Snapshot Ephrin (Ephrin) encodes the ligand of the product of Eph. It is involved in nervous system development. FBgn0039911 Alliance Predicted to enable acetylcholine receptor binding activity and zinc ion binding activity. Predicted to be involved in cholinergic synaptic transmission and positive regulation of neuromuscular synaptic transmission. Predicted to be active in neuromuscular junction and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse). FBgn0024728 UniProtKB May selectively reduce calcium-activated potassium channel (Slo) currents by reducing the number of Slo channels in the plasma membrane. (UniProtKB:Q8MR31) FBgn0039920 Alliance "Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Orthologous to several human genes including MEX3B (mex-3 RNA binding family member B)." FBgn0026199 FlyBase Gene Snapshot myoglianin (myo) encodes a protein expressed primarily in muscle and glia cells. Mutations in myo affect neuronal remodeling during metamorphosis by failing to activate EcR expression in the remodeling neurons. FBgn0039916 FlyBase Gene Snapshot Eye-enriched kainate receptor (Ekar) encodes an ionotropic receptor that responds to the neurotransmitter glutamate. FBgn0028996 FlyBase Gene Snapshot onecut (onecut) encodes a transcription factor that binds two different DNA motifs (Cut and Hox). It is mainly expressed in mature neurons and maintains neuronal identity. FBgn0039909 Alliance "Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)." FBgn0026869 Alliance Enables G/U mismatch-specific uracil-DNA glycosylase activity and double-stranded DNA binding activity. Involved in mismatch repair. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic/larval muscle system; and organism. Orthologous to human TDG (thymine DNA glycosylase). FBgn0039908 FlyBase Gene Snapshot Asator (Asator) encodes a tau-tubulin kinase homolog that is localized to the cytoplasm at interphase. It directly interacts with the spindle matrix protein encoded by Mgtor and localizes to the spindle region during mitosis. FBgn0026262 FlyBase Gene Snapshot TBP-associated factor 3 (Taf3) encodes a protein that interacts with the transcription factor encoded by Trl and is involved in transcriptional activation. FBgn0039907 FlyBase Gene Snapshot "legless (lgs) encodes a conserved transcriptional cofactor of the product of arm that is essential for the transcription of Wingless target genes. It contributes to growth regulation, cell survival and developmental patterning." FBgn0024811 UniProtKB "Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development. (UniProtKB:Q9XYM0)" FBgn0039896 UniProtKB "Catalyzes the conversion of dopaminechrome to 5,6-dihydroxyindole in the eumelanin biosynthetic pathway originating from dopamine (PubMed:34388859). Catalyzes tautomerization of dopaminechrome to 5,6-dihydroxyindole during eumelanin biosynthesis (PubMed:34388859). Acts both dopaminechrome and N-methyl dopaminechrome but not on dopachrome or other aminochromes tested (PubMed:34388859). (UniProtKB:Q9V4C0)" FBgn0039897 Alliance Predicted to enable actin binding activity. Predicted to be involved in positive regulation of actin filament bundle assembly. Located in Z disc. Is expressed in adult head; adult heart; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and spermatozoon. Orthologous to human SYNPO (synaptopodin); SYNPO2 (synaptopodin 2); and SYNPO2L (synaptopodin 2 like). FBgn0026777 FlyBase Gene Snapshot "Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover." FBgn0052850 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Acts upstream of with a negative effect on regulation of dopamine secretion. Predicted to be part of ubiquitin ligase complex. Is expressed in adult head and embryonic/larval central nervous system. Orthologous to human RNF11 (ring finger protein 11). FBgn0039904 UniProtKB May be involved in control of the cell cycle. (UniProtKB:Q9V4C8) FBgn0039902 Alliance Predicted to enable metal ion transmembrane transporter activity. Predicted to be involved in transmembrane transport and zinc ion transport. Predicted to be located in membrane. Is expressed in adult head. Orthologous to human SLC39A9 (solute carrier family 39 member 9). FBgn0042696 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval muscle system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome; NFIA-related disorder; and Sotos syndrome 2. Orthologous to several human genes including NFIC (nuclear factor I C)." FBgn0053481 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. FBgn0051999 Alliance Predicted to enable calcium ion binding activity. Is expressed in embryonic/larval muscle system; somatic muscle primordium; and visceral muscle primordium. Orthologous to several human genes including FBLN1 (fibulin 1). FBgn0051998 Alliance Is expressed in adult head and organism. FBgn0039890 UniProtKB "Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. (UniProtKB:Q7JUN3)" FBgn0039889 Alliance Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Located in cleavage furrow. Is expressed in organism. Orthologous to several human genes including ARL4A (ADP ribosylation factor like GTPase 4A) and ARL4C (ADP ribosylation factor like GTPase 4C). FBgn0051997 Alliance Located in cytosol. Is expressed in adult brain cell body rind. FBgn0052006 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Is expressed in dorsal sensory complex proper primordium; embryonic head sensory system; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1)." FBgn0011747 FlyBase Gene Snapshot Ankyrin (Ank) encodes protein that is recruited to the plasma membrane by its association with the product of beta-Spec. It also binds to the adhesion protein encoded by Nrg leading to accumulation of the products of Ank and beta-Spec at sites of cell-cell adhesion. FBgn0017545 FlyBase Gene Snapshot Ribosomal protein S3A (RpS3A) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. FBgn0004859 FlyBase Gene Snapshot cubitus interruptus (ci) encodes a Zn-finger family of transcription factor. It contributes to Hedgehog (Hh) signaling pathway that is involved in pattern formation and growth control. The product of ci undergoes limited proteolysis to be converted into a truncated form that function as a transcription repressor in the absence of the ligand encoded by hh but is converted into a full-length transcription activator in the presence of the product of hh. FBgn0025740 FlyBase Gene Snapshot "Plexin B (PlexB) encodes a transmembrane receptor for ligands including semaphorins, which signals via RhoGTPases. It can signal both attractive and repulsive axon guidance." FBgn0019985 UniProtKB G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. (UniProtKB:P91685) FBgn0019650 FlyBase Gene Snapshot "twin of eyeless (toy) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to formation of the central nervous system." FBgn0010217 UniProtKB "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. (UniProtKB:Q05825)" FBgn0013749 UniProtKB GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (UniProtKB:P40945) FBgn0002521 FlyBase Gene Snapshot pleiohomeotic (pho) encodes a zinc-finger protein that binds to Polycomb response elements and is required for recruitment of Polycomb group protein complexes to chromatin. It is primarily a transcriptional repressor. FBgn0052017 Alliance Is expressed in adult head. FBgn0039928 UniProtKB "Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). (UniProtKB:Q9V498)" FBgn0024913 FlyBase Gene Snapshot "Activin-beta (Actbeta) encodes a ligand of the TGF beta superfamily. It signals through the type I receptor encoded by babo and the Smad family member encoded by Smox. Actbeta is expressed primarily in the central and peripheral nervous systems and its product regulates aspects of metabolism, insulin signaling, hemocyte development and body size." FBgn0011642 FlyBase Gene Snapshot Zyxin (Zyx) encodes an actin cytoskeleton regulator found at cell-matrix junctions and cell-cell adherens junctions. Its roles include mechanotransduction and regulation of the Hippo signaling pathway. FBgn0039929 Alliance "Predicted to be involved in transcription by RNA polymerase I. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm." FBgn0039930 UniProtKB Involved in mitochondria homeostasis. (UniProtKB:Q9V492) FBgn0039932 FlyBase Gene Snapshot "fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling." FBgn0052016 FlyBase Gene Snapshot "eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation." FBgn0023213 FlyBase Gene Snapshot eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. FBgn0039936 FlyBase Gene Snapshot "Gigyf (Gyf) encodes a protein that is necessary for maintenance of neuromuscular homeostasis. It regulates protein translation, insulin/IGF signaling pathway and autophagy." FBgn0039937 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Orthologous to human FOXJ2 (forkhead box J2) and FOXJ3 (forkhead box J3)." FBgn0039938 FlyBase Gene Snapshot "Sox102F (Sox102F) encodes a transcription factor in the Sox gene family that regulates the Wnt signaling pathway. Its roles include heart development and cardiac function, and wing vein development and patterning." FBgn0039923 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA gene. (UniProtKB:Q9V4F9)" FBgn0024698 UniProtKB "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). (UniProtKB:Q9V726)" FBgn0030538 Alliance Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. FBgn0010473 FlyBase Gene Snapshot "turtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control." FBgn0003386 FlyBase Gene Snapshot Shaker cognate w (Shaw) encodes a voltage-gated potassium channel (Kv3.1) that mediates a non-inactivating potassium current open at resting membrane potential. It is important for controlling excitability of motor neurons and clock neurons. It regulates circadian rhythms and is in a pathway with the product of qsm and Na[+] K[+] Ca[2+] Co-transporter. FBgn0051481 FlyBase Gene Snapshot "proboscipedia (pb) encodes a conserved homeodomain transcription factor. Its role in regional head development, from insects to mammals, likely involves combinatorial regulation both of cell-specific targets and of multiple signaling pathways." FBgn0004577 FlyBase Gene Snapshot "Peroxidase (Pxd) encodes an enzyme that converts hydrogen peroxide to water and molecular oxygen, in the process oxidizing glutathione to glutathione disulfide. It is involved in the cellular response to oxidative stress." FBgn0010453 UniProtKB Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis. (UniProtKB:P40589) FBgn0010549 UniProtKB Vital for development. (UniProtKB:P91660) FBgn0012018 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012016 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0012017 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052525 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052520 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011910 Alliance Predicted to enable UUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011909 Alliance Predicted to enable UUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0014342 FlyBase Gene Snapshot "meiosis I arrest (mia) encodes a paralog of the generally expressed TBP-associated factor encoded by Taf6. mia is expressed only in differentiating male germ cells, starting in the spermatocyte stage. Along with four other testis-specific TBP-associated factors, the product of mia is required for full levels of transcript production from multiple genes expressed in primary spermatocytes in preparation for meiotic cell cycle progression and spermatid differentiation." FBgn0032721 Alliance "Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Predicted to be involved in peptide catabolic process. Predicted to be located in ribosome. Predicted to be active in cytosol. Is expressed in several structures, including adult brain; adult head; embryonic/larval crystal cell; mesoderm; and procrystal cell. Orthologous to human LTA4H (leukotriene A4 hydrolase)." FBgn0032720 Alliance Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in negative regulation of translation and translation. Located in mitochondrion. Is expressed in adult head. Orthologous to human MRPL13 (mitochondrial ribosomal protein L13). FBgn0036290 Alliance "Predicted to enable aldose reductase (NADPH) activity. Involved in fructose biosynthetic process and sorbitol biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10); AKR1B15 (aldo-keto reductase family 1 member B15); and AKR1C4 (aldo-keto reductase family 1 member C4)." FBgn0036362 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0002565 UniProtKB Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (UniProtKB:Q24388) FBgn0036255 UniProtKB Required for autophagy. (UniProtKB:Q9VTU1) FBgn0017424 Alliance Involved in negative regulation of Toll signaling pathway; negative regulation of antimicrobial peptide production; and negative regulation of peptidoglycan recognition protein signaling pathway. Is active in nucleus. FBgn0025885 UniProtKB Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:11121586). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). (UniProtKB:O97477) FBgn0014018 FlyBase Gene Snapshot "Relish (Rel) encodes a transcription factor and the downstream component of the immune deficiency pathway, which regulates the antibacterial response and other less characterized cellular processes." FBgn0038282 Alliance Involved in behavioral response to ethanol and synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in adult head. FBgn0016047 FlyBase Gene Snapshot "no mechanoreceptor potential A (nompA) encodes an apical extracellular matrix protein involved in mechanotransduction. In mechanosensory sensilla, the product of nompAis transported to and incorporated into an apical extracellular cap, which encloses the tips of sensory cilia and connects them to force-transmitting structures. nompA loss causes sensory defects including deafness, touch-insensitivity, and lack of coordination due to loss of proprioception." FBgn0030151 UniProtKB "Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (UniProtKB:Q8SWU7)" FBgn0039817 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). FBgn0003141 UniProtKB Required for pigment and biopterin synthesis. (UniProtKB:P48611) FBgn0036039 FlyBase Gene Snapshot "N(alpha)-acetyltransferase 60 (Naa60) encodes an enzyme that acetylates the cytosolic N terminal methionine of transmembrane proteins. It is associated with intracellular membranes, in particular Golgi membranes, and is essential for normal Golgi organization and chromosome segregation." FBgn0038535 Alliance Located in endomembrane system. Is expressed in adult head; adult heart; and organism. Orthologous to human RRBP1 (ribosome binding protein 1). FBgn0053503 FlyBase Gene Snapshot Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). FBgn0050489 FlyBase Gene Snapshot Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). FBgn0000109 UniProtKB "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (UniProtKB:P12426)" FBgn0039757 Alliance A structural constituent of ribosome. Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 8. Orthologous to human RPS7 (ribosomal protein S7). FBgn0042173 Alliance Predicted to enable tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity. FBgn0003892 FlyBase Gene Snapshot "patched (ptc) is a segment polarity gene that encodes a 12-pass transmembrane protein involved in Hh signalling regulation. ptc product contributes to the binding, internalization and degradation of the ligand encoded by hh, limiting its activity spatial range. ptc product also represses the constitutive signaling activity of the transmembrane protein encoded by smo." FBgn0005278 UniProtKB "Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (UniProtKB:P40320)" FBgn0052000 Alliance Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and organism. Used to study Kufor-Rakeb syndrome. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; hereditary spastic paraplegia 78; and primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). FBgn0021760 FlyBase Gene Snapshot chromosome bows (chb) encodes a microtubule plus-end tracking protein that promotes stabilization of microtubule dynamics. It is required for several mitotic aspects such as kinetochore attachment and central spindle formation. chb product is also essential for construction of polarized microtubule network in egg chambers and fusome formation in spermatogenesis and oogenesis. FBgn0036640 UniProtKB "May be involved in the export of mRNA from the nucleus to the cytoplasm (PubMed:11780633). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci (PubMed:31368590, PubMed:31384064, PubMed:31570835). Does not affect piRNA biogenesis (PubMed:31384064). The interaction with Panx stabilizes the nuclear protein complex (PubMed:31384064). Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports (PubMed:31384064, PubMed:31570835). (UniProtKB:Q9VV73)" FBgn0067783 FlyBase Gene Snapshot Dephosphocoenzyme A carrier (DPCoAC) encodes a mitochondrial carrier that transports dephosphocoenzyme A from the mitochondrial matrix to the cytosol where it is converted to coenzyme A. FBgn0035981 Alliance "Predicted to be active in nuclear speck. Is expressed in several structures, including antennal primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human FAM76A (family with sequence similarity 76 member A) and FAM76B (family with sequence similarity 76 member B)." FBgn0001098 FlyBase Gene Snapshot Glutamate dehydrogenase (Gdh) encodes a glutamate dehydrogenase involved glutamate metabolism. FBgn0002174 UniProtKB May act as a tumor suppressor in larval imaginal disks. (UniProtKB:Q27237) FBgn0017418 FlyBase Gene Snapshot ariadne 1 (ari-1) encodes an E3 ubiquitin ligase that interacts with the E2 ubiquitin conjugating enzyme encoded by Ubc10. The product of ari-1 and Ubc10 jointly ubiquitylate isoform A of the ecdysone receptor encoded by EcR. FBgn0002921 FlyBase Gene Snapshot Na pump alpha subunit (Atpalpha) encodes an integral membrane cation antiporter protein that utilizes ATP to shuttle Na[+] and K[+] across the plasma membrane to maintain ion homeostasis. FBgn0000083 Alliance Enables spectrin binding activity. Involved in endosome transport via multivesicular body sorting pathway; maintenance of cell polarity; and wing disc dorsal/ventral pattern formation. Located in cell cortex and endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including ANXA7 (annexin A7). FBgn0011672 FlyBase Gene Snapshot "Malvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling." FBgn0036414 FlyBase Gene Snapshot "nanchung (nan) encodes a member of the transient Receptor Potential (TRP) channel family. It is involved in the response to different stimuli such as startle, humidity or sound." FBgn0053489 Alliance Is expressed in spermatozoon. Orthologous to human EFHB (EF-hand domain family member B). FBgn0053490 Alliance Orthologous to human EFHB (EF-hand domain family member B). FBgn0036544 FlyBase Gene Snapshot sugar-free frosting (sff) encodes a protein involved in neuromuscular junction development and protein N-linked glycosylation. FBgn0034274 Alliance Predicted to enable histone binding activity. Predicted to be part of Set1C/COMPASS complex. FBgn0034275 Alliance "Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; clypeo-labral primordium; dorsal apodeme anlage; dorsal ectoderm anlage; and embryonic/larval spiracle primordium. Orthologous to human SLC26A11 (solute carrier family 26 member 11)." FBgn0022740 FlyBase Gene Snapshot HLH54F (HLH54F) encodes a bHLH transcription factor that regulates caudal visceral mesoderm development. FBgn0027572 UniProtKB Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway. (UniProtKB:Q7KML2) FBgn0026309 FlyBase Gene Snapshot adrift (aft) encodes a protein involved in tracheal development. FBgn0028744 UniProtKB Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. (UniProtKB:Q7K0Y1) FBgn0028743 FlyBase Gene Snapshot "Double hit (Dhit) encodes a protein that negatively regulates Galpha signaling and is involved in several GPCR-mediated signaling and developmental programs, such as asymmetric cell division in the sensory organ lineage." FBgn0026316 FlyBase Gene Snapshot Ubiquitin conjugating enzyme 10 (Ubc10) encodes an E2 ubiquitin conjugating enzyme that interacts with the E3 ubiquitin ligase encoded by ari-1. Both jointly ubiquitylate isoform A of the ecdysone receptor encoded by EcR. FBgn0034279 Alliance Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human XKR4 (XK related 4); XKR6 (XK related 6); and XKR7 (XK related 7). FBgn0034277 FlyBase Gene Snapshot Oligosaccharide transferase Delta subunit (OstDelta) encodes a protein involved in the cellular encapsulation response. FBgn0034276 Alliance Predicted to enable sarcosine dehydrogenase activity. Involved in S-adenosylmethionine cycle and sarcosine catabolic process. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). FBgn0035917 FlyBase Gene Snapshot "Z band alternatively spliced PDZ-motif protein 66 (Zasp66) encodes a scaffold protein that binds the product of Actn and localizes to Z-discs in muscle cells. It plays a role in muscle development, especially in myofibril assembly." FBgn0036101 FlyBase Gene Snapshot "Ninjurin A (NijA) encodes a transmembrane protein of the conserved Ninjurin family. It is upregulated in response to injury and infection, suggesting a role in immune or stress responses. When overexpressed the product of NijA causes cell death." FBgn0032388 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome and maturation of 5S rRNA. Part of precatalytic spliceosome. Is expressed in spermatozoon. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP)." FBgn0030887 Alliance Involved in motor neuron axon guidance and synaptic target inhibition. Predicted to be active in extracellular space. Is expressed in muscle cell of A1-7 ventral longitudinal muscle 2 and muscle cell of ventral longitudinal muscle 1. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome; ocular hypertension; and open-angle glaucoma (multiple). Orthologous to several human genes including GLDN (gliomedin). FBgn0030892 Alliance Predicted to enable RNA endonuclease activity. Predicted to be involved in nuclear mRNA surveillance of mRNP export. Is expressed in organism. Orthologous to human SWT1 (SWT1 RNA endoribonuclease homolog). FBgn0020429 FlyBase Gene Snapshot Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. FBgn0036790 FlyBase Gene Snapshot Allatostatin C receptor 1 (AstC-R1) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. FBgn0010424 Alliance "Predicted to enable calcium ion binding activity and enzyme regulator activity. Is expressed in several structures, including adult heart; border follicle cell; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and somatic muscle primordium. Orthologous to human CALML6 (calmodulin like 6)." FBgn0036911 Alliance Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to human FIBP (FGF1 intracellular binding protein). FBgn0036900 Alliance Involved in dendrite morphogenesis. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. FBgn0015721 FlyBase Gene Snapshot "king tubby (ktub) encodes a protein that belongs to the tubby and tubby-like protein family. It functions in endocytosis of the rhodopsin encoded by ninaE, retinal degeneration upon light stimulation, and the localization of channel encoded by the channel encoded by trp in cilia." FBgn0053494 Alliance Is expressed in embryonic/larval midgut and lamina. FBgn0011862 Alliance Predicted to enable GGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0040227 UniProtKB "mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. (UniProtKB:Q9VCK0)" FBgn0025790 FlyBase Gene Snapshot TAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. FBgn0032699 FlyBase Gene Snapshot "CG10383 encodes a hydrolase involved in the regulation of glycosylphosphatidylinositol metabolism, determination of lifespan and sleep." FBgn0036302 Alliance Orthologous to several human genes including SOWAHB (sosondowah ankyrin repeat domain family member B). FBgn0016034 UniProtKB "Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage. Indirectly required to position the microtubule organizing center in stage 2-6 oocytes. (UniProtKB:Q9VNS0)" FBgn0031883 FlyBase Gene Snapshot Caper (Caper) encodes an RNA-binding protein involved in regulation of alternative mRNA splicing. FBgn0031835 Alliance Enables dipeptidyl-peptidase activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in proteolysis and regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of Kv4.3-DPP10 channel complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP6 (dipeptidyl peptidase like 6). FBgn0031115 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be part of RQC-trigger complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). FBgn0039313 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0000286 FlyBase Gene Snapshot Chorion factor 2 (Cf2) encodes a zinc-finger DNA-binding transcription factor that is involved in follicle cell fate determination and regulation of myogenic gene expression. FBgn0028425 Alliance "Predicted to enable L-amino acid transmembrane transporter activity. Involved in several processes, including L-leucine import across plasma membrane; cellular response to L-leucine; and positive regulation of insulin secretion. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval motor neurons; embryonic/larval neuromuscular junction; and ganglia. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to several human genes including SLC7A5 (solute carrier family 7 member 5)." FBgn0003380 FlyBase Gene Snapshot "Shaker (Sh) encodes the structural alpha subunit of a voltage-gated potassium channel. It plays a key role in maintaining electrical excitability in neurons and muscle cells, as well as regulating neurotransmitter release at the synapse." FBgn0037153 Alliance "Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; central brain primordium; dorsal ectoderm; and ganglia. Orthologous to human MOXD2P (monooxygenase DBH like 2, pseudogene)." FBgn0038448 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human SVOPL (SVOP like). FBgn0036681 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0061197 Alliance Is expressed in adult head; scolopidial dendrite; spermatid; spermatocyte; and spermatozoon. FBgn0027780 UniProtKB "Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. (UniProtKB:Q9VLL0)" FBgn0028560 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and spermatozoon. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). FBgn0003464 UniProtKB Has a role in eye development. Calcium-regulated non-lysosomal thiol-protease. (UniProtKB:P27398) FBgn0023023 FlyBase Gene Snapshot "Collapsin Response Mediator Protein (CRMP) encodes a protein that contributes to pyrimidine catabolism, beta-alanine biosynthesis, neurogenesis and behavior." FBgn0037222 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0037836 Alliance Is expressed in spermatozoon. FBgn0037986 Alliance Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0038440 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:Q9VEU0)" FBgn0020371 Alliance Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and protein insertion into mitochondrial inner membrane. Is active in mitochondrial inner membrane. Is expressed in organism. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A) and TIMM17B (translocase of inner mitochondrial membrane 17B). FBgn0030657 Alliance "Predicted to enable SUMO ligase activity. Predicted to be involved in double-strand break repair via homologous recombination and protein sumoylation. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in embryonic brain and organism. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)." FBgn0043070 Alliance Enables serine hydrolase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in adult head; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to several human genes including NDRG1 (N-myc downstream regulated 1); NDRG2 (NDRG family member 2); and NDRG3 (NDRG family member 3). FBgn0029941 Alliance Predicted to enable mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Predicted to be involved in RNA destabilization. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; organism; and spermatozoon. Orthologous to human ZC3H18 (zinc finger CCCH-type containing 18). FBgn0036574 UniProtKB "Has an important role in DNA replication and in maintaining genome integrity during replication stress (By similarity). Promotes PCNA deubiquitination (By similarity). As component of the Elg1 RFC-like complex, regulates the functions of the DNA polymerase processivity factor PCNA by unloading it from DNA after replication during the S phase of the cell cycle (PubMed:27198229). The PCNA-unloading might be regulated via interaction with the Enok acetyltransferase complex (PubMed:27198229). Might have a role in restarting of stalled/regressed replication forks during replication stress (By similarity). In the ovaries, has a role in nurse cell endoreplication (PubMed:27198229). (UniProtKB:Q86BP6)" FBgn0003118 FlyBase Gene Snapshot "pointed (pnt) encodes an ETS family transcriptional activator that functions downstream of Ras signaling. It is necessary and sufficient for triggering cellular senescence upon Ras activation, and by doing so suppresses Ras-driven tumor growth." FBgn0004595 FlyBase Gene Snapshot "prospero (pros) encodes a protein that promotes the expression of neural differentiation genes and represses neuroblast stem cell identity genes and cell cycle proliferation genes; it is also important for astrocyte development. The product of pros is asymmetrically localized to the basal cortex during neuroblast asymmetric cell division, resulting in its partioning into GMC daughter cells, where it translocates into the nucleus." FBgn0016038 Alliance Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Is expressed in embryonic/larval midgut and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). FBgn0033566 Alliance Predicted to be involved in chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of Ino80 complex. Is expressed in organism. Orthologous to human INO80E (INO80 complex subunit E). FBgn0003189 FlyBase Gene Snapshot rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. FBgn0032202 FlyBase Gene Snapshot "REPTOR-binding partner (REPTOR-BP) encodes a transcription factor constitutively localized in the nucleus. Together with its binding partner encoded by REPTOR, it mediates much of the transcriptional response observed upon Tor complex 1 inhibition." FBgn0002773 FlyBase Gene Snapshot "Myosin light chain 2 (Mlc2) encodes a subunit of the myosin complex involved in myofibril assembly. It contributes to different flight-related processes including wing beat frequency, and indirect flight muscle contraction." FBgn0037455 Alliance "Predicted to enable oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor." FBgn0031450 FlyBase Gene Snapshot "Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs) encodes a protein that, together with the product encoded by Stam, forms the ESCRT-0 complex. This complex is responsible for the initial selection of ubiquitinated proteins that are ultimately degraded in lysosomes." FBgn0050011 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adult brain; cuboidal/columnar epithelium; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to several human genes including TFCP2 (transcription factor CP2) and TFCP2L1 (transcription factor CP2 like 1)." FBgn0050159 Alliance "Predicted to be active in extracellular space. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval muscle system; gut section; and hindgut proper primordium. Orthologous to human C3orf33 (chromosome 3 open reading frame 33)." FBgn0050423 Alliance Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Is expressed in adult head and adult heart. Orthologous to human LEPROT (leptin receptor overlapping transcript) and LEPROTL1 (leptin receptor overlapping transcript like 1). FBgn0038194 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VFP1) FBgn0051665 FlyBase Gene Snapshot weary (wry) encodes a ligand for the receptor encoded by N. It is involved in the Notch signaling pathway and normal heart function. FBgn0051720 Alliance Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0005666 FlyBase Gene Snapshot "bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle." FBgn0052206 Alliance Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. FBgn0052442 Alliance "Involved in positive regulation of cell division. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator)." FBgn0052495 Alliance Predicted to enable ATP binding activity and glutathione synthase activity. Involved in detoxification of arsenic-containing substance. Is expressed in adult head. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). FBgn0052568 Alliance Predicted to enable protein phosphatase activator activity. Predicted to be involved in signal transduction. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. FBgn0052656 Alliance "Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; embryonic/larval fat body; and embryonic/larval proventriculus. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated)." FBgn0031518 Alliance "Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including arteriovenous malformation; basal ganglia calcification; hematologic cancer (multiple); infantile myofibromatosis; and kidney cancer (multiple). Orthologous to human TEK (TEK receptor tyrosine kinase); PDGFRA (platelet derived growth factor receptor alpha); and PDGFRB (platelet derived growth factor receptor beta)." FBgn0023531 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic central brain glial cell; embryonic central brain neurons; embryonic/larval nervous system; and ganglia. Orthologous to human KIAA1217 (KIAA1217) and SRCIN1 (SRC kinase signaling inhibitor 1)." FBgn0053170 Alliance Is expressed in adult head and spermatozoon. FBgn0053198 UniProtKB "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. (UniProtKB:Q86BE9)" FBgn0035802 FlyBase Gene Snapshot "Puratrophin-1-like (Pura) encodes a RhoGEF involved in leg morphogenesis, neuron morphogenesis, and locomotor rhythm regulation." FBgn0032120 Alliance "Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in trans-Golgi network membrane organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; dorsal ectoderm; embryonic/larval central nervous system; eye disc; and hindgut anlage in statu nascendi. Orthologous to several human genes including ATP10A (ATPase phospholipid transporting 10A (putative)) and ATP10D (ATPase phospholipid transporting 10D (putative))." FBgn0041723 UniProtKB "Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. (UniProtKB:Q76NQ1)" FBgn0053459 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in isolated microphthalmia 6. Orthologous to human PRSS56 (serine protease 56). FBgn0052311 FlyBase Gene Snapshot zormin (zormin) encodes a protein found in the Z-disc and the M-line of muscles. It probably has a structural function. FBgn0003016 FlyBase Gene Snapshot outspread (osp) encodes a protein that contributes to embryonic crystal cell formation and the proper morphogenesis of the adult wing. FBgn0035028 UniProtKB May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. (UniProtKB:Q9W145) FBgn0015925 FlyBase Gene Snapshot "capsuleen (csul) encodes a protein arginine methyltransferase that carries out symmetric dimethylation of arginine residues. It forms a complex with the product of vls, which is the substrate recognition subunit. Primary substrates for this complex include the spliceosomal Sm proteins. The products of csull and vls function in germline specification and are required for proper localization of the product of tud to the posterior pole of the oocyte." FBgn0013305 Alliance "Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process. Predicted to be active in organelle membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic proventriculus; embryonic/larval nervous system; and ganglia. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)." FBgn0021761 UniProtKB "Component of the nuclear pore complex (PubMed:17410542). Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope (PubMed:22718353). In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad (PubMed:21696798). Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:22718353, PubMed:26341556). Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes (PubMed:10511559, PubMed:17277377, PubMed:17410542, PubMed:9732281). Has a role in male spermatogenesis and fertility (PubMed:10511559, PubMed:9732281). Has a role in germ line cell proliferation (PubMed:21696798). (UniProtKB:Q9V463)" FBgn0038474 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head; adult heart; and organism. Orthologous to human MRPS11 (mitochondrial ribosomal protein S11). FBgn0025456 FlyBase Gene Snapshot Cellular Repressor of E1A-stimulated Genes (CREG) encodes an essential protein located in lysosomes and related subcellular compartments. FBgn0026379 FlyBase Gene Snapshot "Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements." FBgn0039207 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Used to study cystic fibrosis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). FBgn0032455 Alliance Is expressed in adult head; organism; and spermatozoon. FBgn0038886 Alliance "Predicted to enable UDP-glycosyltransferase activity. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3)." FBgn0039215 Alliance "Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; hindgut anlage; and mesoderm. Orthologous to human CLASRP (CLK4 associating serine/arginine rich protein)." FBgn0039714 FlyBase Gene Snapshot Zinc/iron regulated transporter-related protein 99C (Zip99C) encodes an iron transporter located on the Golgi and endoplasmic reticulum that moves iron from the cytoplasm into the secretory compartments. FBgn0039711 Alliance Is expressed in organism. FBgn0002567 FlyBase Gene Snapshot "Rab32 (Rab32) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in eye development, autophagy and lipid storage." FBgn0032001 Alliance Predicted to enable cytidine deaminase activity and zinc ion binding activity. Predicted to be involved in cytidine deamination. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). FBgn0031548 Alliance Predicted to be active in plasma membrane. FBgn0025682 FlyBase Gene Snapshot supercoiling factor (scf) encodes two polypeptides: DCB45 and its N-teminally truncated form Scf. Scf is a nuclear protein that introduces negative supercoils into DNA in conjunction with topoisomerase II. DCB45 is an endoplasmic reticulum-resident protein. FBgn0032907 Alliance "Predicted to enable class I DNA-(apurinic or apyrimidinic site) endonuclease activity and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1)." FBgn0031813 Alliance "Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be active in peroxisome. Is expressed in adult head; adult heart; embryonic/larval midgut; embryonic/larval oenocyte; and organism. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl)." FBgn0026620 FlyBase Gene Snapshot "transforming acidic coiled-coil protein (tacc) encodes a centrosomal protein that helps to stabilize microtubules. It seems to influence microtubules indirectly, primarily through its interaction with the product of msps. It is also phosphorylated by the product of aurA, and this activates its ability to stabilize microtubules." FBgn0003721 UniProtKB "Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. (UniProtKB:P49455)" FBgn0034405 FlyBase Gene Snapshot Juvenile hormone epoxide hydrolase 2 (Jheh2) encodes an enzyme that hydrolyzes cis-stilbene oxide. Jheh2 expression changes are associated with increased tolerance to oxidative stress. FBgn0039915 FlyBase Gene Snapshot "GABA transporter (Gat) encodes a protein belonging to the SLC family that is expressed primarily in astrocytes, where it is thought to be required for uptake of GABA and other small molecules. It likely plays an important role in setting the excitatory/inhibitory balance of the CNS." FBgn0020445 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0004509 UniProtKB Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (UniProtKB:P26016) FBgn0000117 FlyBase Gene Snapshot "armadillo (arm) encodes the Drosophila homolog of beta-catenin. It plays separable roles in cell adhesion and Wingless signaling. It links classic cadherin cell adhesion receptors to alpha-catenin and the actin cytoskeleton, and it acts as the key regulated effector of Wingless signaling, working with TCF/LEF proteins as a transcriptional co-activator." FBgn0022361 FlyBase Gene Snapshot "Purine-rich binding protein-alpha (Pur-alpha) encodes a DNA- and RNA-binding protein involved in the regulation of transcription and cell-cycle. In the cytoplasm it is found in motile RNPs, indicating a role in RNA localization." FBgn0023175 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (UniProtKB:Q9V5C6)" FBgn0010329 FlyBase Gene Snapshot "Tyramine beta hydroxylase (Tbh) encodes a monooxygenase and the key limiting enzyme in octopamine synthesis. It regulates egg laying, positive associative olfactory learning and memory, aggression, flight initiation and maintenance, locomotor activity and attraction to ethanol containing food sources." FBgn0011754 FlyBase Gene Snapshot "Phosphorylase kinase gamma (PhKgamma) encodes a protein involved in gastrulation, embryonic mesoderm formation and adult leg musculature development." FBgn0001991 FlyBase Gene Snapshot "Ca[2+]-channel protein alpha[[1]] subunit D (Ca-alpha1D) encodes the pore-forming alpha subunit of an L-type voltage-gated Ca[2+] channel expressed in neurons. It mediates Ca[2+] influx, affecting action potential generation and muscle contraction." FBgn0032456 Alliance "Enables ATPase-coupled inorganic anion transmembrane transporter activity. Involved in monoatomic anion transmembrane transport; renal tubular secretion; and response to toxic substance. Located in plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group))." FBgn0034053 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V7G5) FBgn0034054 Alliance "Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm." FBgn0050069 FlyBase Gene Snapshot SAXO downstream of blistered (Sdb) encodes a large protein conserved in other insects with up to 80 copies of a tandem array of a 29 amino acid repeat. Ubiquitous Sdb RNAi causes lethality and wing-specific RNAi causes wing adhesion defects. FBgn0039114 FlyBase Gene Snapshot Lipid storage droplet-1 (Lsd-1) encodes a protein associated with lipid droplets. It protects lipid droplets from lipase mediated remobilization and facilitates lipolysis by serving as an anchoring point for lipases such as the one encoded by Hsl. It is involved in lipid storage amount regulation and energy homeostasis in concert with the product of Lsd-2. FBgn0039116 Alliance Predicted to be active in nucleus. Orthologous to human DNAJC8 (DnaJ heat shock protein family (Hsp40) member C8). FBgn0015513 FlyBase Gene Snapshot "myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure." FBgn0039120 FlyBase Gene Snapshot "Nucleoporin 98-96kD (Nup98-96) encodes a precursor protein that is cleaved into Nup98 and Nup96 proteins, two integral parts of the nuclear pore. In the male gonad, loss of Nup98-96 function results in premature differentiation of germ line cells at the expense of proliferation." FBgn0039118 Alliance Is expressed in embryonic hypopharynx; embryonic ventral apodeme; and organism. FBgn0039117 FlyBase Gene Snapshot twister (tst) encodes a protein that regulates mRNA alternative splicing FBgn0039115 UniProtKB 3'-to-5' exoribonuclease specific for small oligoribonucleotides. (UniProtKB:Q9VCI0) FBgn0039113 Alliance Involved in wound healing. Is expressed in adult head and adult heart. FBgn0035477 Alliance Orthologous to several human genes including FAM110A (family with sequence similarity 110 member A); FAM110B (family with sequence similarity 110 member B); and FAM110C (family with sequence similarity 110 member C). FBgn0035478 Alliance Is expressed in organism. FBgn0004880 FlyBase Gene Snapshot scratch (scrt) encodes a zinc finger C2H2 transcription factor involved in the negative regulation of genes promoting non-neuronal cell fates. FBgn0035482 Alliance Orthologous to human MITD1 (microtubule interacting and trafficking domain containing 1). FBgn0004895 FlyBase Gene Snapshot "Forkhead box L1 (FoxL1) encodes a transcription factor that is expressed in ventral intersegmental muscle 5 and in the hindgut. FoxL1 product contributes to salivary gland morphology and the migration of tissues that migrate in close proximity to the FoxL1-expressing cells, such as hemocytes, germ cells and Malpighian tubules." FBgn0035483 UniProtKB "Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway. (UniProtKB:Q9VZJ9)" FBgn0045479 UniProtKB "One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose. (UniProtKB:P83293)" FBgn0045478 UniProtKB One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. (UniProtKB:P83294) FBgn0045477 UniProtKB One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. (UniProtKB:P83295) FBgn0052255 UniProtKB "One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose. (UniProtKB:P83297)" FBgn0035484 Alliance Predicted to enable D-ribulokinase activity. Involved in response to endoplasmic reticulum stress. Predicted to be active in cytoplasm. Orthologous to human FGGY (FGGY carbohydrate kinase domain containing). FBgn0035481 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2)." FBgn0035479 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. FBgn0027552 Alliance "Enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in cytosol. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10) and AKR1B15 (aldo-keto reductase family 1 member B15)." FBgn0035476 Alliance "Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10); AKR1B15 (aldo-keto reductase family 1 member B15); and AKR1C4 (aldo-keto reductase family 1 member C4)." FBgn0035475 Alliance Orthologous to human TMEM267 (transmembrane protein 267). FBgn0030545 Alliance Predicted to enable copper ion binding activity. Predicted to be involved in response to metal ion. Orthologous to human CUTA (cutA divalent cation tolerance homolog). FBgn0026713 FlyBase Gene Snapshot pre-mRNA processing factor 16 (Prp16) encodes a protein involved in alternative mRNA splicing regulation. FBgn0030552 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head and adult heart. Orthologous to human MRPL38 (mitochondrial ribosomal protein L38). FBgn0030554 Alliance "Predicted to enable tRNA-dihydrouridine20 synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; antennal primordium; ganglia; gut section; and head epidermis primordium. Orthologous to human DUS2 (dihydrouridine synthase 2)." FBgn0030558 Alliance Enables L-tyrosine:2-oxoglutarate aminotransferase activity. Involved in L-phenylalanine catabolic process and tyrosine catabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase). FBgn0002917 FlyBase Gene Snapshot narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception. FBgn0030562 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryonic hypopharynx. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0030559 Alliance Predicted to be involved in positive regulation of plasminogen activation. Predicted to be located in plasma membrane. Is expressed in adult head. Orthologous to human PLGRKT (plasminogen receptor with a C-terminal lysine). FBgn0030556 Alliance Enables mRNA guanylyltransferase activity. Involved in 7-methylguanosine mRNA capping and positive regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Is expressed in adult head and organism. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). FBgn0030555 Alliance "Involved in negative regulation of cell communication; negative regulation of circadian sleep/wake cycle, sleep; and ubiquitin-dependent protein catabolic process. Located in neuron projection and neuronal cell body. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4)." FBgn0030551 Alliance Is expressed in organism. FBgn0003053 FlyBase Gene Snapshot "pebbled (peb) encodes a protein that acts as a tissue-specific transcriptional attenuator. It contributes to embryonic morphogenesis and development of ovary, retina and respiratory system." FBgn0025739 FlyBase Gene Snapshot partner of numb (pon) encodes a protein that functions upstream of the cell fate determinant encoded by numb during asymmetric cell divisions. It contributes to asymmetric localization of the numb product and the subsequent suppression of Notch signaling. FBgn0029718 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human MRPL30 (mitochondrial ribosomal protein L30). FBgn0022942 UniProtKB "Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure. (UniProtKB:Q7K4N3)" FBgn0029720 Alliance Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Is expressed in adult head. Orthologous to human PLA2G3 (phospholipase A2 group III). FBgn0025615 FlyBase Gene Snapshot Torsin (Torsin) encodes an AAA-ATPase that is implicated in the export of large ribonuclear protein particles through the nuclear membrane. It regulates dopamine levels. FBgn0011277 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central brain primordium; embryonic pars intercerebralis; ganglia; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. Orthologous to human NHLH1 (nescient helix-loop-helix 1)." FBgn0025612 Alliance Predicted to be involved in cilium organization. Predicted to be active in ciliary basal body. Is expressed in spermatozoon. Orthologous to human CFAP126 (cilia and flagella associated protein 126). FBgn0025613 Alliance Is expressed in spermatozoon. FBgn0023395 FlyBase Gene Snapshot Chd3 (Chd3) encodes a nuclear ATP-dependent nucleosome remodeler of the CHD family. It associates with active chromatin and utilizes the energy of ATP hydrolysis to move nucleosomes along DNA. FBgn0036879 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0036878 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0036877 Alliance "Predicted to enable acid phosphatase activity. Predicted to be located in extracellular exosome and nucleus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4)." FBgn0036876 Alliance "Predicted to enable acid phosphatase activity. Predicted to be located in extracellular exosome and nucleus. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4)." FBgn0036875 Alliance "Predicted to enable acid phosphatase activity. Predicted to be located in extracellular exosome and nucleus. Is expressed in amnioserosa; embryonic/larval salivary gland; and yolk nucleus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4)." FBgn0036874 Interactive Fly cation channel that mediates the mechanotransduction of class III dendritic arborization neurons of the PNS FBgn0052208 Alliance Is expressed in adult heart. FBgn0036871 Alliance Is expressed in adult head. FBgn0036870 Alliance Is expressed in adult head. FBgn0031126 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VRB3) FBgn0019929 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0030157 Alliance Is expressed in adult head. FBgn0030158 Alliance Is expressed in adult head. FBgn0030159 Alliance Is expressed in adult head; embryonic esophagus; embryonic ventral epidermis; and embryonic/larval posterior spiracle. FBgn0030160 Alliance "Is expressed in several structures, including embryonic epipharynx; embryonic foregut; embryonic head epidermis; embryonic hypopharynx; and epidermis." FBgn0030162 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; and embryonic/larval salivary gland. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0024807 FlyBase Gene Snapshot DISCO Interacting Protein 1 (DIP1) encodes a protein that binds to double-stranded RNA and pre-miRNA. It is involved in the defense response to virus. FBgn0053502 UniProtKB Molecular scaffold for (UniProtKB:Q8SY96) FBgn0052819 Alliance Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cilium assembly; flagellated sperm motility; and microtubule nucleation. Predicted to be located in cytoplasm. Predicted to be active in microtubule cytoskeleton. Is expressed in spermatozoon and testis. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human TEKT3 (tektin 3) and TEKT5 (tektin 5). FBgn0040028 Alliance Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in flagellated sperm motility and microtubule nucleation. Predicted to be located in cytoplasm. Is expressed in chordotonal neurons; spermatogonium; spermatozoon; and testis. FBgn0052820 Alliance Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in flagellated sperm motility and microtubule nucleation. Predicted to be located in cytoplasm. Is expressed in adult head; spermatozoon; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human TEKT3 (tektin 3) and TEKT5 (tektin 5). FBgn0027588 Alliance "Predicted to enable glucan 1,3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Located in endomembrane system and extracellular region. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to several human genes including GANAB (glucosidase II alpha subunit)." FBgn0052230 Alliance Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 21. Orthologous to human NDUFA4 (NDUFA4 mitochondrial complex associated) and NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2). FBgn0010215 FlyBase Gene Snapshot "alpha Catenin (alpha-Cat) encodes a protein which interacts with scrib to sustain apicobasal polarity of epithelial cells. Cooperation between alpha-Cat, scrib and a complex of septate junctions regulates epithelial tissue growth through interaction with the Hippo pathway." FBgn0039530 FlyBase Gene Snapshot Tusp (Tusp) encodes a protein involved in SNARE complex assembly. FBgn0039532 FlyBase Gene Snapshot "Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis." FBgn0027494 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 9. Orthologous to human RPS10 (ribosomal protein S10) and RPS10P5 (ribosomal protein S10 pseudogene 5). FBgn0039536 UniProtKB Component of the na (narrow abdomen) sodium channel complex. In the circadian clock neurons it functions with na and unc79 to promote circadian rhythmicity. (UniProtKB:Q9VB11) FBgn0039537 Alliance "Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human HSDL2 (hydroxysteroid dehydrogenase like 2)." FBgn0045862 FlyBase Gene Snapshot barentsz (btz) encodes a component of the exon junction complex that is recruited to spliced mRNAs to mark where introns have been removed. It is required for the posterior localization of osk mRNA. FBgn0039543 Alliance Predicted to enable carnitine O-octanoyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in peroxisome. Is expressed in adult head; embryonic hindgut; embryonic/larval oenocyte; and organism. Orthologous to human CROT (carnitine O-octanoyltransferase). FBgn0003330 UniProtKB "E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG complexes act via modification of histones, such as methylation, deacetylation, ubiquitination rendering chromatin heritably changed in its expressibility. May play a role in meiotic sister chromatid cohesion. (UniProtKB:Q9VB08)" FBgn0002772 Alliance "Predicted to enable calcium ion binding activity. Involved in mesoderm development. Located in cytosol. Part of muscle myosin complex. Is expressed in several structures, including adult heart; border follicle cell; embryonic/larval muscle system; muscle cell; and organism subdivision. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B)." FBgn0039529 Alliance Is expressed in adult head. FBgn0260484 UniProtKB "One HIP oligomer binds the ATPase domains of at least two Hsc70 molecules dependent on activation of the Hsc70 ATPase by Hsp40. Stabilizes the ADP state of Hsc70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of Hsc70 with various target proteins (By similarity). (UniProtKB:C4NYP8)" FBgn0021738 Alliance Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is expressed in embryonic brain and larval ventral nerve cord. FBgn0029679 Alliance Predicted to enable inositol hexakisphosphate binding activity and phosphate transmembrane transporter activity. Involved in synaptic target recognition. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. FBgn0031644 Alliance Orthologous to human SAMD15 (sterile alpha motif domain containing 15). FBgn0031645 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Located in plasma membrane. Is expressed in several structures, including adult CNS glial cell; adult brain cell body rind; adult head; mesoderm; and neuroblasts." FBgn0003372 Alliance Predicted to be an extracellular matrix structural constituent. Involved in puparial adhesion. Located in adhesive extracellular matrix. Is expressed in embryonic/larval midgut; embryonic/larval salivary gland; and organism. FBgn0031650 Alliance Involved in positive regulation of apoptotic process. Part of Bcl-2 family protein complex. FBgn0039331 Alliance "Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)." FBgn0039332 Alliance "Is expressed in adult head; adult mushroom body; glial cell; larval ventral nerve cord; and synaptic neuropil domain. Orthologous to human NRROS (negative regulator of reactive oxygen species) and TSKU (tsukushi, small leucine rich proteoglycan)." FBgn0032859 UniProtKB Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (UniProtKB:Q9VIM5) FBgn0051687 Alliance Predicted to be part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). FBgn0032863 FlyBase Gene Snapshot "Cell division cycle 23 (Cdc23) encodes a subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding." FBgn0032864 Alliance "Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; foregut primordium; hindgut proper primordium; and mesoderm. Orthologous to human PRCP (prolylcarboxypeptidase)." FBgn0042175 Alliance Enables serine hydrolase activity. Predicted to be involved in lipid metabolic process. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to several human genes including PLA2G15 (phospholipase A2 group XV). FBgn0051683 Alliance Enables serine hydrolase activity. Predicted to be involved in lipid metabolic process. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to several human genes including PLA2G15 (phospholipase A2 group XV). FBgn0032860 Alliance Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Orthologous to human TMIE (transmembrane inner ear). FBgn0032858 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in organism. FBgn0031688 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VMT6) FBgn0031692 Alliance Predicted to enable calcium ion binding activity and enzyme regulator activity. Located in striated muscle thin filament. Is expressed in adult heart. FBgn0031690 Alliance Predicted to enable GTPase activator activity. Orthologous to human TBC1D19 (TBC1 domain family member 19). FBgn0033538 Alliance "Predicted to enable 5'-nucleotidase activity. Predicted to be involved in nucleotide catabolic process. Is expressed in several structures, including adult head; embryonic/larval nervous system; embryonic/larval oenocyte; ganglia; and sense organ." FBgn0033540 UniProtKB "Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:36302967). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:36302967). Binding by the elongator complex stabilizes microtubules and promotes their growth (PubMed:36302967). This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells (PubMed:36302967). Involved in the regulation of the STAT pathway (Ref.4). (UniProtKB:Q7K4B3)" FBgn0033539 FlyBase Gene Snapshot "G protein-coupled receptor kinase interacting ArfGAP (Git) encodes an Arf-GAP that forms a scaffold with the Rho-type guanine nucleotide exchange factor encoded by RtGEF aiding in activation of the kinase encoded by Pak. The product of Git has roles in muscle morphogenesis, synaptic vesicle recycling, and regulation of tissue growth." FBgn0031195 Alliance "Predicted to be located in membrane. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic hypopharynx; embryonic ventral epidermis; and gut section." FBgn0031196 Alliance Predicted to be involved in cilium assembly. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Orthologous to human CLUAP1 (clusterin associated protein 1). FBgn0031194 Alliance "Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to several human genes including PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J)." FBgn0010316 FlyBase Gene Snapshot dacapo (dap) encodes a Cyclin-dependent kinase inhibitor in the CIP/KIP family. It binds to CycE-Cdk2 complexes and thereby inhibits their protein kinase activity. Upregulation of dap is required after the last mitosis for arresting cells in G1/G0 before terminal differentiation in many post-mitotic cell types. FBgn0043530 Alliance Predicted to enable odorant binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0033633 Alliance Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm. Is expressed in embryonic/larval somatic muscle cell and mesoderm. Orthologous to human SMYD4 (SET and MYND domain containing 4). FBgn0040503 Alliance Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC3A (C-type lectin domain family 3 member A). FBgn0015872 FlyBase Gene Snapshot "Drip (Drip) encodes a protein that belongs to the MIP/aquaporin family involved in the transport of water across the cell membrane. In addition to its cellular roles, it has been implicated in regulating aspects of reproduction and aging." FBgn0033015 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in nervous system development. Part of brahma complex. Is expressed in organism. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to several human genes including DPF2 (double PHD fingers 2) and DPF3 (double PHD fingers 3). FBgn0033019 Alliance Predicted to be involved in chromatin remodeling. Predicted to be part of Ino80 complex. Is expressed in organism. Orthologous to human INO80B (INO80 complex subunit B). FBgn0033020 Alliance "Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1)." FBgn0033021 Alliance "Predicted to enable protein serine/threonine phosphatase activity. Predicted to be located in cytoplasm. Is expressed in organism. Orthologous to human PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)." FBgn0050441 Alliance Predicted to be involved in centrosome localization; cilium organization; and protein localization to cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi apparatus; centrosome; and cilium. Orthologous to human IFT20 (intraflagellar transport 20). FBgn0033017 Alliance Predicted to be involved in protein homooligomerization. Is expressed in organism. Orthologous to several human genes including KCTD10 (potassium channel tetramerization domain containing 10). FBgn0052133 FlyBase Gene Snapshot PAX transcription activation domain interacting protein (Ptip) encodes a component of a Histone H3K4 methyltransferase complex that contributes to Trithorax-mediated epigenetic imprinting during development. FBgn0053196 FlyBase Gene Snapshot "dumpy (dpy) encodes an extracellular protein involved in epidermal-cuticle attachment, aposition of wing surfaces and trachea development." FBgn0050220 Alliance Predicted to enable GAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0053353 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053354 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053355 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053357 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053358 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053359 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053360 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053361 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053362 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053364 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053365 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053366 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053367 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053368 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053369 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053370 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053372 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053373 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053374 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053375 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053376 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053377 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053378 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053379 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053380 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053381 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053382 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053383 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053384 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053385 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053386 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053387 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053388 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053389 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053390 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053391 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053392 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053393 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053394 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053395 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053396 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053397 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053398 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053399 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053400 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053401 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053402 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053403 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053404 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053405 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053406 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053407 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053408 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053409 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053410 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053411 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053412 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053413 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053414 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053415 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053417 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053418 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053419 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053420 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053421 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053422 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053423 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053424 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053425 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053426 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053427 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053428 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053429 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053430 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053431 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053432 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053433 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053434 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053435 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053436 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053437 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053438 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053439 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053440 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053441 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053442 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053443 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053444 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053445 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053446 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053447 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053448 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053449 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053450 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053451 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0053452 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosolic ribosome. FBgn0040849 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult olfactory receptor neuron Ir41a and antennal lobe glomerulus VM6. FBgn0033005 UniProtKB ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity). (UniProtKB:Q9V9E3) FBgn0033010 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in germline cell; organism; pole plasm; and primordial germ cell. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to several human genes including ATF6 (activating transcription factor 6)." FBgn0026238 FlyBase Gene Snapshot "gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance." FBgn0013348 FlyBase Gene Snapshot "Troponin C at 41C (TpnC41C) is expressed predominantly in the pupal and adult tubular muscles, with minor amounts in the flight muscle. The encoded protein binds calcium to regulate muscle contraction. Its absence in tubular muscle is compensated by up-regulation of the product of TpnC4." FBgn0032949 Alliance "Involved in lipophagy. Located in lipid droplet. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; adult heart; and gut section. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to several human genes including LAMP1 (lysosomal associated membrane protein 1)." FBgn0030715 FlyBase Gene Snapshot Odorant receptor 13a (Or13a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0030717 Alliance Predicted to be involved in mitochondrial fission. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head and organism. Used to study Charcot-Marie-Tooth disease type 6. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1E. Orthologous to human SLC25A46 (solute carrier family 25 member 46). FBgn0000611 FlyBase Gene Snapshot "extradenticle (exd) encodes a homeodomain transcription factor that is imported to the nuclueus upon binding the product of hth. The protein complex hth-exd are Hox cofactors but also have additional Hox-independent functions such as in antennal development, proximal appendages patterning, and cell division promotion of the undifferentiated eye field." FBgn0030720 Alliance "Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to be located in nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3)." FBgn0030721 Alliance Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). FBgn0030723 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in embryonic brain; larval ventral nerve cord; and lateral cord glial cell. FBgn0030725 Alliance Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). FBgn0028397 FlyBase Gene Snapshot Tob (Tob) encodes a protein involved in long-term memory. FBgn0030724 Alliance Predicted to be involved in mitochondrion organization and oxidative phosphorylation. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; gastric caecum; and organism. Orthologous to human NIPSNAP1 (nipsnap homolog 1) and NIPSNAP2 (nipsnap homolog 2). FBgn0030722 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in regulation of cytoskeleton organization. Predicted to be active in axoneme. Orthologous to human SPEF1 (sperm flagellar 1). FBgn0003969 FlyBase Gene Snapshot vacuolar peduncle (vap) encodes a GTPase-activating protein for Ras-family small GTPases that functions in the intracellular Ras-MAP kinase pathway. vap loss produces age-dependent neurodegeneration in the adult brain. The product of vap function in neuronal survival is mediated through the EGF receptor pathway and Rab5-dependent endocytosis. FBgn0030719 UniProtKB Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). (UniProtKB:Q9VXK6) FBgn0030718 FlyBase Gene Snapshot NADH dehydrogenase (ubiquinone) 20 kDa subunit (ND-20) encodes a component of the mitochondrial electron transport chain and is involved in determination of life span. FBgn0030716 Alliance "Part of ciliary transition fiber. Is expressed in several structures, including adult antennal sense organ; male germline cell; and scolopidial cilium. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and nephronophthisis 15. Orthologous to human CEP164 (centrosomal protein 164)." FBgn0053236 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV12)" FBgn0053237 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV13)" FBgn0053238 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV14)" FBgn0053239 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV15)" FBgn0053240 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV12)" FBgn0053241 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV15)" FBgn0053242 Alliance Enables protein kinase regulator activity. Located in cytoplasm and nucleus. Part of protein kinase CK2 complex. FBgn0053243 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV19)" FBgn0053244 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV12)" FBgn0053245 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV12)" FBgn0053246 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV22)" FBgn0053247 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV23)" FBgn0029174 FlyBase Gene Snapshot FK506-binding protein 59kD (Fkbp59) encodes a peptidylprolyl isomerase involved in the regulation of calcium transport and phototransduction. FBgn0032153 Alliance Predicted to enable PDZ domain binding activity and microtubule binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be active in dendrite. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain). FBgn0010520 Alliance Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in embryonic/larval brain; imaginal disc; and organism. Orthologous to human FCF1 (FCF1 rRNA-processing protein). FBgn0024285 FlyBase Gene Snapshot "Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site." FBgn0040064 Alliance "Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; epithelium; germline cell; gut section; and visceral mesoderm derivative. Orthologous to human ACAA2 (acetyl-CoA acyltransferase 2)." FBgn0032160 Alliance Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1). FBgn0032161 Alliance Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1). FBgn0032162 Alliance Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1). FBgn0032166 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and longitudinal visceral muscle primordium." FBgn0032167 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval dorsal vessel; plasmatocyte primordium; and yolk nucleus. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4)." FBgn0051712 Alliance Enables U1 snRNP binding activity. Located in nucleus. Orthologous to human ARGLU1 (arginine and glutamate rich 1). FBgn0051876 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head. FBgn0032163 Alliance Colocalizes with cilium. Is expressed in chordotonal neurons; sensory neurons; and spermatogonium. Orthologous to human DRC3 (dynein regulatory complex subunit 3). FBgn0025700 Alliance "Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Located in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human SSR3 (signal sequence receptor subunit 3)." FBgn0032156 Alliance Predicted to enable translation activator activity. Predicted to be involved in regulation of translational initiation. Predicted to be active in cytosol. Is expressed in adult head; dorsal pharyngeal muscle cell; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. Orthologous to human MIF4GD (MIF4G domain containing). FBgn0053300 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in amnioserosa; embryonic/larval salivary gland; and organism. FBgn0004867 FlyBase Gene Snapshot Ribosomal protein S2 (RpS2) encodes a highly conserved component of the 40S ribolomal comlex. RpS2 product controls the assembly and nuclear export of the pre-ribosome and appears to have a specific function during oogenesis. FBgn0032154 FlyBase Gene Snapshot "mitochondrial DNA helicase (mtDNA-helicase) encodes the replicative mitochondrial DNA helicase, which is responsible for NTPase-dependent double-stranded DNA unwinding during mitochondrial DNA replication. It has roles in mitochondrial genome maintenance, and mitochondrial function." FBgn0031089 Alliance Involved in positive regulation of Notch signaling pathway and tissue regeneration. Predicted to be located in extracellular space. FBgn0031092 Alliance "Predicted to enable delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; cuboidal/columnar epithelium; embryonic/larval muscle system; and gut section. Orthologous to human ECH1 (enoyl-CoA hydratase 1)." FBgn0031094 Alliance Predicted to be involved in DNA damage checkpoint signaling and TOR signaling. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in organism. Orthologous to human TIPRL (TOR signaling pathway regulator). FBgn0031097 FlyBase Gene Snapshot "obstructor-A (obst-A) encodes a protein that forms a core complex with chitin and the chitin modifying proteins encoded by serp and knk. This complex is required for assembly, maturation and preservation of the chitinous cuticles at the end of embryogenesis and probably throughout larval development." FBgn0022770 Alliance Predicted to enable chitin binding activity. Involved in sexual reproduction. Located in extracellular space. FBgn0015789 FlyBase Gene Snapshot Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. FBgn0031099 Alliance Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process. Is expressed in embryonic/larval crystal cell; organism; procrystal cell; and yolk nucleus. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). FBgn0031098 Alliance Predicted to be involved in neurogenesis. Predicted to be active in P-body and cytosol. Is expressed in organism. Orthologous to human BTBD2 (BTB domain containing 2). FBgn0003654 FlyBase Gene Snapshot "short wing (sw) encodes the non-catalytic intermediate chain subunit of the cytoplasmic dynein motor complex. It contributes to wing development, eye development, oocyte development and polarity, mitotic cell division, and neuronal transport and neurogenesis." FBgn0053499 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0052823 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in transport along microtubule. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0053497 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0067861 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in microtubule-based movement. Located in sperm flagellum. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0000084 FlyBase Gene Snapshot Annexin B10 (AnxB10) encodes a calcium-dependent phospholipid binding protein. FBgn0031093 Alliance Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Is expressed in embryonic Malpighian tubule; embryonic hindgut; embryonic/larval midgut; embryonic/larval visceral muscle cell; and organism. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). FBgn0031091 Interactive Fly chromatin component - conserved epigenetic 'reader' that activates the male germline sexual program - binds histone H3 N-terminal tails with a preference for dimethyl lysine 4 FBgn0031090 FlyBase Gene Snapshot Rab35 (Rab35) encodes a protein that regulates proximal versus distal growth of seamless tubes in the terminal cells of the tracheal system. FBgn0030759 Alliance Is expressed in adult head. FBgn0061200 UniProtKB "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050). Functions as a scaffolding element in the nuclear phase of the NPC (PubMed:17682050). Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner (PubMed:17682050). Required for nuclear import of Mad (PubMed:20547758). Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment (PubMed:20174442). Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome (PubMed:20174442). Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy (PubMed:20174442). Preferentially binds to NARs of the male X chromosome (PubMed:20174442). In males, together with Mgtor, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes (PubMed:16543150). May play a role in double strand break DNA repair (PubMed:26502056). (UniProtKB:Q9VXE6)" FBgn0025743 UniProtKB "Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42. (UniProtKB:Q9VXE5)" FBgn0030761 Alliance "Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm; plasma membrane; and ruffle. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J) and INPP5K (inositol polyphosphate-5-phosphatase K)." FBgn0015615 FlyBase Gene Snapshot Structural maintenance of chromosomes 3 (SMC3) encodes a subunit of the cohesin complex. It is involved in planar cell polarity by regulating the membrane enrichment of the transmembrane cadherin encoded by stan. FBgn0011826 UniProtKB "Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. (UniProtKB:Q27889)" FBgn0011742 FlyBase Gene Snapshot "Actin-related protein 2 (Arp2) encodes one of the actin-related proteins within the Arp2/3 complex, which is the basic actin nucleator of eukaryotes." FBgn0030756 Alliance Predicted to enable sodium-dependent organic anion transmembrane transporter activity. Predicted to be involved in sodium-dependent organic anion transport. Predicted to be located in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in intestinal disease. Orthologous to several human genes including SLC10A5 (solute carrier family 10 member 5). FBgn0034478 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. FBgn0041150 Alliance Predicted to enable monoatomic ion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head; adult inner optic chiasma giant glial cell; adult optic chiasma glial cell; adult outer optic chiasma giant glial cell; and organism. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein). FBgn0033404 FlyBase Gene Snapshot Odorant receptor 45a (Or45a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0033403 Alliance Is expressed in adult head. FBgn0033250 Alliance Is expressed in adult head; embryonic head sensory system; embryonic/larval nervous system; ganglia; and sensory nervous system primordium. FBgn0034072 FlyBase Gene Snapshot "Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity." FBgn0033155 FlyBase Gene Snapshot "Bromodomain-containing protein, 140kD (Br140) encodes a histone acetyltransferase that is a component of the Enok complex, which interacts with the product of elg1 via Br140 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading." FBgn0025360 FlyBase Gene Snapshot Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. FBgn0031646 Alliance Involved in cuticle development. Located in cytoplasmic vesicle. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and gut section. FBgn0015000 FlyBase Gene Snapshot beta subunit of type I geranylgeranyl transferase (betaggt-I) encodes a protein involved in embryonic heart tube development. FBgn0031655 FlyBase Gene Snapshot "Marcal1 (Marcal1) encodes an ATP-dependent DNA annealing helicase that recognizes single-stranded to double-stranded DNA transitions. It maintains genomic integrity through its roles in DNA repair, DNA replication, DNA recombination and gene expression." FBgn0031657 Alliance Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). FBgn0031662 Alliance "Predicted to be involved in oligosaccharide biosynthetic process. Predicted to be located in membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation If. Orthologous to human MPDU1 (mannose-P-dolichol utilization defect 1)." FBgn0033911 FlyBase Gene Snapshot Vesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. FBgn0034071 Alliance Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human TMEM259 (transmembrane protein 259). FBgn0034479 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; antennal anlage; and central brain anlage. Orthologous to human SLC22A13 (solute carrier family 22 member 13) and SLC22A14 (solute carrier family 22 member 14)." FBgn0031651 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Orthologous to human MRPL24 (mitochondrial ribosomal protein L24)." FBgn0031654 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in organism. FBgn0031653 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. FBgn0031652 FlyBase Gene Snapshot "jetlag (jet) encodes an F-box protein that is a component of an SCF E3 ubiquitin ligase complex. It targets the product of tim for degradation upon light exposure, and is essential for photic entrainment of the circadian clock." FBgn0015834 UniProtKB "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProtKB:O02195)" FBgn0031661 FlyBase Gene Snapshot "GDP-mannose 4,6-dehydratase (Gmd) encodes an enzyme that catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (also known as GDP-4-dehydro-alpha-D-rhamnose), the first step in the 'de novo' synthesis of GDP-L-fucose from GDP-mannose." FBgn0031663 UniProtKB "Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. (UniProtKB:Q9VMW7)" FBgn0031664 Alliance Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human UBXN7 (UBX domain protein 7). FBgn0031659 Alliance Predicted to be involved in microtubule cytoskeleton organization; mitochondrial transport; and plasma membrane bounded cell projection organization. Predicted to be located in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). FBgn0037028 Alliance "Is expressed in several structures, including CNS glial cell; dorsal sensory complex proper primordium; embryonic central brain neurons; ganglia; and sense organ. Orthologous to human FAM234A (family with sequence similarity 234 member A)." FBgn0031660 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Orthologous to human MRPL28 (mitochondrial ribosomal protein L28). FBgn0061515 FlyBase Gene Snapshot "endosulfine (endos) encodes a protein that, after its phosphorylation by the kinase encoded by gwl, inhibits the phosphatase encoded by tws. This inhibition is important for the entry of cells into M phase during the cell cycle." FBgn0052580 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval salivary gland and spermatozoon. FBgn0051961 Alliance Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human TBCC (tubulin folding cofactor C). FBgn0053505 Alliance "Enables U3 snoRNA binding activity. Predicted to be located in nucleolus. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human RRP9 (ribosomal RNA processing 9, U3 small nucleolar RNA binding protein)." FBgn0053506 Alliance Predicted to be active in membrane. Is expressed in adult head. Orthologous to human TMEM177 (transmembrane protein 177). FBgn0053508 Alliance "Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval tracheal dorsal trunk; gustatory sensory organ; olfactory receptor neuron of dorsal organ; tarsal segment; and terminal organ." FBgn0053509 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0053510 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0053511 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0053512 Alliance Involved in synapse organization. Predicted to be active in neuron projection membrane. FBgn0053513 Interactive Fly voltage/Mg2+-dependent Ca2+ channels activated by glutamate - required for olfactory learning FBgn0053514 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head. Orthologous to human TTPAL (alpha tocopherol transfer protein like). FBgn0053516 Alliance Involved in store-operated calcium entry and synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. FBgn0053519 FlyBase Gene Snapshot Obscurin (Obsc) encodes a titin-like protein located at the midline of the muscle thick filaments that is needed for assembly of a symmetrical sarcomere. It is involved in myogenesis and the Hippo signalling pathway. FBgn0053523 Alliance Located in endomembrane system. Is expressed in adult head and spermatozoon. Orthologous to human MOSPD2 (motile sperm domain containing 2). FBgn0053527 UniProtKB "Ligand for the neuropeptide SIFamide receptor (PubMed:16378592). Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination (PubMed:17126293, PubMed:26469541). Also involved in promoting sleep (PubMed:24658384). (UniProtKB:Q6IGX9)" FBgn0053530 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0053531 Interactive Fly "expressed in larval peripheral nerves - loss of function resulted in severely reduced ensheathment of axons and reduced axon caliber - a strong dominant genetic interaction was found between Ddr and the type XV/XVIII collagen Multiplexin (Mp), suggesting Ddr functions as a collagen receptor to drive axon wrapping, in adult nerves, loss of Ddr decreased long-term survival of sensory neurons and significantly reduced axon caliber without overtly affecting ensheathment - glial gene required for axon ensheathment" FBgn0053532 UniProtKB "Galactose-specific lectin that displays calcium-dependent activity (PubMed:16475980, PubMed:17287021). Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization (PubMed:17287021). This is likely by interacting with carbohydrates on the surface of the hemocytes (PubMed:17287021). Also displays agglutination activity against the Gram-negative bacterium E.coli (PubMed:17287021). (UniProtKB:Q59DY6)" FBgn0053533 UniProtKB "Galactose-specific lectin that displays calcium-dependent activity (PubMed:16475980, PubMed:17287021). Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization (PubMed:17287021). This is likely by interacting with carbohydrates on the surface of the hemocytes (PubMed:17287021). Also displays agglutination activity against the Gram-negative bacterium E.coli (PubMed:17287021). (UniProtKB:Q59DY5)" FBgn0053542 FlyBase Gene Snapshot "unpaired 3 (upd3) encodes a ""cytokine"" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation." FBgn0053543 Alliance Predicted to be active in neuron projection. Is expressed in adult head. FBgn0053526 FlyBase Gene Snapshot Phosphatase 1 nuclear targeting subunit (PNUTS) encodes a protein phosphatase 1 binding protein involved in developmental growth and gene expression. FBgn0053547 FlyBase Gene Snapshot "Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release." FBgn0053551 Alliance Predicted to enable CGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0032789 Alliance Located in egg chorion. Is expressed in follicle cell and wing disc. FBgn0053504 Alliance Enables mRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and oocyte development. Located in histone locus body. Part of U7 snRNP and cytoplasmic U snRNP body. FBgn0053534 Alliance Predicted to enable GCU codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0053535 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0053536 Alliance Predicted to enable UUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0053537 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0053538 Alliance Predicted to enable AGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0053539 Alliance Predicted to enable UGG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0002183 FlyBase Gene Snapshot "dre4 (dre4) encodes a chromatin regulator that, along with the product of Ssrp, forms the facilitates chromatin transcription (FACT) protein complex. FACT facilitates GAGA factor-directed chromatin remodeling." FBgn0030018 UniProtKB Activates the JUN N-terminal pathway during dorsal closure. (UniProtKB:Q95UN8) FBgn0010263 FlyBase Gene Snapshot RNA-binding protein 9 (Rbp9) encodes a putative RNA binding protein involved in the establishment of the blood-brain barrier and control of germ cell proliferation. FBgn0052484 FlyBase Gene Snapshot "Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation." FBgn0004648 UniProtKB "Metallocarboxypeptidase that catalyzes the release of C-terminal arginine or lysine residues from peptides and proteins (PubMed:12393882, PubMed:16556608, PubMed:20386952, PubMed:20600119, PubMed:31309630). Functionally important for processing a broad range of proteins including growth factors, peptide hormones (such as Akh) and neuropeptides (PubMed:16556608, PubMed:20386952, PubMed:20600119, PubMed:27430952, PubMed:31309630). Consequently, it is involved in a wide range of processes including viability, memory formation, locomotive activity, wing formation, and peptide-regulated behaviors such as starvation-induced hyperactivity, appetitive gustatory preference, and cold and ethanol sensitivity (PubMed:20386952, PubMed:20600119, PubMed:27430952, PubMed:31309630). Key enzyme in neuropeptide processing (PubMed:31309630). Involved in regulation of memory formation, possibly via the insulin pathway in neurosecretory cells (PubMed:27430952). (UniProtKB:P42787)" FBgn0020493 FlyBase Gene Snapshot Daughters against dpp (Dad) encodes the inhibitory SMAD in the BMP/Dpp pathway. It is involved in growth regulation and developmental patterning. FBgn0029723 Alliance Enables proctolin receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Is expressed in head. FBgn0001301 FlyBase Gene Snapshot "kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals." FBgn0035331 FlyBase Gene Snapshot "Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility." FBgn0031689 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9VMT5) FBgn0053548 Alliance Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to be part of chromatin. Is expressed in eye; photoreceptor neurons; and spermatozoon. FBgn0053552 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. FBgn0040726 Alliance "Involved in salt aversion; sensory perception of salty taste; and synapse organization. Located in plasma membrane. Is expressed in several structures, including amnioserosa anlage; anterior wing margin; ganglia; gustatory receptor neuron of the wing; and taste bristle." FBgn0038643 Alliance Predicted to enable chitin binding activity. FBgn0053554 UniProtKB "Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair (PubMed:15528408). Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV (PubMed:15528408). During wing development, required for activity of Notch and its coactivator mam (PubMed:16508010). Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes (PubMed:16508010). (UniProtKB:Q8I8U7)" FBgn0053556 FlyBase Gene Snapshot "formin 3 (form3) encodes a protein that belongs to the formin family, which functions in various actin-based processes. It is involved in tracheal fusion." FBgn0053557 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in dorsal median cell; larval ventral nerve cord; and organism. Orthologous to human SCX (scleraxis bHLH transcription factor) and TCF15 (transcription factor 15)." FBgn0000575 UniProtKB "Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer. (UniProtKB:P18491)" FBgn0038087 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Is expressed in embryonic brain; larval ventral nerve cord; and ventral nerve cord primordium. FBgn0010317 FlyBase Gene Snapshot Cyclin J (CycJ) encodes a cyclin-dependent protein serine/threonine kinase regulator that contributes to oogenesis and the early embryonic division cycles. FBgn0003231 UniProtKB "Required for selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs (PubMed:12446795, PubMed:2510997). (UniProtKB:P14199)" FBgn0000625 FlyBase Gene Snapshot "eyegone (eyg) encodes a Pax family transcription factor that acts as a transcriptional repressor. In eye development, the product of eyg promotes cell proliferation in the larval eye disc through activation of Jak/STAT pathway. It also plays both positive and negative roles in head vortex development." FBgn0003984 FlyBase Gene Snapshot "vein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing." FBgn0010894 FlyBase Gene Snapshot "sinuous (sinu) encodes a claudin that contributes to the assembly of septate junctions. It is involved in the development of heart, tracheal tree and the glial blood-brain barrier." FBgn0003429 FlyBase Gene Snapshot slowpoke (slo) encodes the structural alpha subunit of a BK ('maxi K') calcium-activated potassium channel. It regulates neurotransmitter release at the synapse and maintain electrical excitability in neurons and muscle cells. FBgn0004587 UniProtKB Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. (UniProtKB:P26686) FBgn0004882 FlyBase Gene Snapshot oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. FBgn0003015 UniProtKB Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nanos (nos) RNA and staufen protein at the posterior pole. (UniProtKB:P25158) FBgn0005561 FlyBase Gene Snapshot "shaven (sv) encodes a transcription factor and a member of the paired box family of genes. It is primarily involved in the terminal differentiation of specific cell types during the development of a variety of sensory organs, including the bristles and the eye." FBgn0033170 Alliance Enables calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Is expressed in organism. Orthologous to human PLA2G3 (phospholipase A2 group III). FBgn0039927 Alliance Predicted to enable kainate selective glutamate receptor activity. Predicted to be involved in regulation of synaptic activity. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult head and transmedullary neuron Tm5c. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive intellectual developmental disorder 6; childhood absence epilepsy; and chronic obstructive pulmonary disease. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1) and GRIK2 (glutamate ionotropic receptor kainate type subunit 2). FBgn0027339 FlyBase Gene Snapshot jim (jim) encodes a zinc finger C2H2 transcription factor involved in dendrite morphogenesis and regulation of chromatin silencing. FBgn0034990 Alliance Predicted to enable triglyceride lipase activity. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0015770 FlyBase Gene Snapshot "MstProx (MstProx) encodes a protein with an intracellular Toll/interleukin-1 receptor domain and extracellular Leucine-rich repeats. Although also designated as ""Toll-3"" and related to Tl, it is not known to activate the canonical Toll signaling pathway or antimicrobial response." FBgn0041164 FlyBase Gene Snapshot "armitage (armi) encodes a highly conserved cytosolic 5'-3' RNA helicase that is involved in biogenesis of PIWI-interacting RNAs (piRNAs), which suppress transposable elements in the fly germline." FBgn0037313 Alliance Predicted to be located in lysosomal membrane. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human TMEM9B (TMEM9 domain family member B) and TMEM9 (transmembrane protein 9). FBgn0041707 FlyBase Gene Snapshot 7B2 (7B2) encodes a peptidase required for the zymogen conversion and secretion of the prohormone convertase 2 encoded by amon. FBgn0002774 FlyBase Gene Snapshot "maleless (mle) encodes a helicase and a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. mle homozygous mutant males die as larvae, while females are viable." FBgn0002873 FlyBase Gene Snapshot mushroom body defect (mud) encodes regulates spindle orientation via interactions with the dynein complex. FBgn0004102 FlyBase Gene Snapshot "ocelliless (oc) encodes a homeodomain transcription factor with homology to vertebrate Otx genes. oc mediates development of the eye-antennal segment in the embryo, as well as development of adult optic lobe neurons." FBgn0033807 Alliance Predicted to enable channel activity. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including AQP12A (aquaporin 12A) and AQP12B (aquaporin 12B). FBgn0003124 UniProtKB May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (PubMed:1660828). Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles (PubMed:24829288). Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules (PubMed:24829288). (UniProtKB:P52304) FBgn0000303 FlyBase Gene Snapshot Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. FBgn0002440 FlyBase Gene Snapshot "lethal (3) malignant blood neoplasm (l(3)mbn) is a tumor suppressor gene with mutants showing abnormal proliferation of blood cells, differentiation of lamellocytes and melanotic nodule formation in the larva." FBgn0041242 FlyBase Gene Snapshot Gustatory receptor 47a (Gr47a) encodes a protein involved in bitter taste perception. FBgn0004606 UniProtKB "Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. (UniProtKB:P28166)" FBgn0033195 Alliance Is expressed in organism. FBgn0003720 UniProtKB Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence (UniProtKB:P18102) FBgn0028572 FlyBase Gene Snapshot quick-to-court (qtc) encodes an alpha-helical coiled-coiled protein whose mutants exhibit altered male courtship behavior. FBgn0038651 UniProtKB Involved in autophagy. Plays a role in late steps of autophagy. (UniProtKB:Q9VE34) FBgn0004607 FlyBase Gene Snapshot "Zn finger homeodomain 2 (zfh2) encodes a putative transcription factor. Its roles include specification of cell fates and promotion of apoptosis during CNS development, and proximal-distal patterning during wing and leg imaginal disc development." FBgn0005558 FlyBase Gene Snapshot "eyeless (ey) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to brain formation." FBgn0037317 Alliance Predicted to enable DNA-binding transcription factor activity; chromatin insulator sequence binding activity; and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in chromosome. Is expressed in organism. Orthologous to human REPIN1 (replication initiator 1). FBgn0003950 FlyBase Gene Snapshot uncoordinated (unc) encodes a basal body-associated protein that is required for normal ciliogenesis. unc depletion results in spermatids with defective flagella and truncated cilia in mechanosensory and chemosensory neurons. Its name arises from the severe uncoordination phenotype due to a lack of proprioceptive sensory feedback. FBgn0023416 FlyBase Gene Snapshot Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. FBgn0000259 FlyBase Gene Snapshot "Casein kinase II beta subunit (CkIIbeta) encodes the regulatory subunit of the CKII holoenzyme, a protein serine/threonine kinase composed of a and b subunits. Interactions have been reported with other kinases (e.g., the products of PIP4K and S6kII), the RNA-binding protein encoded by orb , the Hedgehog signaling pathway and clock proteins such as the products of tim and per. The product of CkIIbeta functions in oogenesis, neurogenesis, development (brain and other tissues) as well as circadian behavior." FBgn0003741 UniProtKB "Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl (PubMed:1690860, PubMed:2441872, PubMed:2503251, PubMed:7680770). Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins (PubMed:8334698). Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site (PubMed:9418892). No known function in males (PubMed:1690860, PubMed:2441872, PubMed:2503251, PubMed:7680770). (UniProtKB:P11596)" FBgn0040097 Alliance Predicted to enable galactose binding activity and signaling receptor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0028841 FlyBase Gene Snapshot "juvenile hormone acid methyltransferase (jhamt) encodes an enzyme that catalyzes (2E, 6E)farnesoate/ Juvenile hormone (JH) acid methylation to produce JH bisepoxide in the corpora allata. Loss of jhamt produces a delayed wandering larval stage and decreased female fecundity." FBgn0000241 FlyBase Gene Snapshot "brown (bw) encodes a member of the traffic ATPase (or ABC) family of membrane transporters. It is believed to heterodimerize with the product of w. bw and w are necessary to import guanine, a precursor for the red pteridine pigments, into pigment cells of the eyes, Malpighian tubules and testis sheath." FBgn0004907 FlyBase Gene Snapshot "14-3-3zeta (14-3-3zeta) encodes three acidic protein isoforms due to alternative splicing. The isoforms homo- and heterodimerize with each other and other members of the family. It functions in multiple signaling pathways, most prominently in the Ras/MAPK cascade. It is involved in epithelial cell polarity, development of the eye, embryogenesis and in adult associative learning." FBgn0039914 FlyBase Gene Snapshot maverick (mav) encodes a protein involved in the BMP signaling pathway. FBgn0019828 FlyBase Gene Snapshot don juan (dj) encodes a protein present in spermatids and sperm. FBgn0004369 FlyBase Gene Snapshot "Protein tyrosine phosphatase 99A (Ptp99A) encodes a transmembrane receptor tyrosine phosphatase. Its single mutants have no known phenotypes, but Ptp99A synergizes with Ptp69D to increase the penetrance of the Ptp69D motor axon defects. Ptp99A mutations also suppress the 'bypass' motor axon phenotype produced by Lar mutations." FBgn0010114 FlyBase Gene Snapshot hikaru genki (hig) encodes a secretory matrix protein localized to the synaptic clefts of cholinergic synapses. It is required for the accumulation of acetylcholine receptor subunits on the postsynaptic membranes. FBgn0000427 UniProtKB Required for proper assembly of the eggshell. (UniProtKB:P18171) FBgn0040107 Alliance Predicted to enable galactose binding activity. Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC3A (C-type lectin domain family 3 member A). FBgn0029676 FlyBase Gene Snapshot "Hsc/Hsp70-interacting protein related (HIP-R) encodes an ortholog of the human Hsp70 interacting protein (HIP), which is a co-chaperone that stabilizes the ADP-bound conformation of Hsp70." FBgn0050048 Alliance Predicted to be involved in calcium ion transport. Predicted to be part of polycystin complex. FBgn0026059 FlyBase Gene Snapshot Myosin heavy chain-like (Mhcl) encodes a protein that interacts with the product of rols during myoblast fusion. FBgn0005427 FlyBase Gene Snapshot "erect wing (ewg) encodes a transcription factor that is essential for synaptic growth at neuromuscular junctions, specification of photoreceptor subtypes, and formation of indirect flight muscles. ewg product has also been linked to the Hippo and Wingless pathways and serves as a major target of the RNA-binding protein encoded by elav." FBgn0051266 Alliance Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head. FBgn0051439 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval proventriculus; embryonic/larval salivary gland; and organism. FBgn0000053 FlyBase Gene Snapshot "GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities." FBgn0000567 FlyBase Gene Snapshot Ecdysone-induced protein 74EF (Eip74EF) encodes a transcription factor that responds to different concentrations of 20-hydroxyecdysone. It contributes to puparium formation and autophagy. FBgn0052333 Alliance Predicted to be involved in cellular lipid metabolic process. Is expressed in antennal disc; eye disc; leg disc; and wing disc. Orthologous to human FAM135A (family with sequence similarity 135 member A) and FAM135B (family with sequence similarity 135 member B). FBgn0041605 FlyBase Gene Snapshot "complexin (cpx) encodes a presynaptic cytosolic protein that regulates SNARE complex assembly and fuction. It has both positive and negative roles in synaptic transmission, serving as the synaptic vesicle fusion clamp and as an activator of evoked release." FBgn0052576 Alliance "Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde transport, endosome to Golgi. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to several human genes including GOLT1B (golgi transport 1B)." FBgn0052602 Alliance Predicted to be an extracellular matrix structural constituent. Involved in chorion-containing eggshell formation. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval salivary gland and organism. FBgn0053111 Alliance "Predicted to be involved in neuron projection morphogenesis and positive regulation of neuron migration. Predicted to be active in axonal growth cone; cell leading edge; and cytoplasm. Is expressed in several structures, including anal pad primordium; anterior endoderm; embryonic anal pad; embryonic/larval midgut primordium; and gut section." FBgn0039396 UniProtKB "Binds to the cardioactive peptide (CCAP), which is a neuropeptide. (UniProtKB:Q868T3)" FBgn0053558 FlyBase Gene Snapshot missing-in-metastasis (mim) encodes a protein involved in guided cell migration via endocytosis inhibition of the product encoded by Cortactin. FBgn0001148 UniProtKB Expressed in segmentally repeating pattern to define the polarity of embryonic segments. (UniProtKB:P09082) FBgn0014141 FlyBase Gene Snapshot "cheerio (cher) encodes a dimeric F-actin crosslinking protein of the filamin protein family. It functions to organize the F-actin cytoskeleton in multiple contexts including ovarian germline ring canals, migrating somatic cells, and neuronal growth cones." FBgn0010382 UniProtKB Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex. (UniProtKB:P54733) FBgn0004575 FlyBase Gene Snapshot Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. FBgn0000042 UniProtKB "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (UniProtKB:P10987)" FBgn0034976 Alliance Predicted to enable ATP binding activity; ATP hydrolysis activity; and ATP-dependent chromatin remodeler activity. Predicted to be active in nucleus. Orthologous to human RAD54L2 (RAD54 like 2). FBgn0034982 UniProtKB Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. (UniProtKB:Q9W1A2) FBgn0020385 FlyBase Gene Snapshot pugilist (pug) encodes the trifunctional enzyme methylenetetrahydrofolate dehydrogenase involved in the pigmentation of pteridines and ommochromes. FBgn0037822 UniProtKB Probable S-adenosyl-L-methionine-dependent methyltransferase. (UniProtKB:Q9VGY5) FBgn0038295 FlyBase Gene Snapshot "Guanylyl cyclase at 88E (Gyc88E) encodes an atypical soluble guanylyl cyclase. It forms heterodimers with the products of Gyc89Da or Gyc89Db to form an oxygen-sensitive soluble guanylyl cyclase, which likely functions as a neuronal oxygen detector, activated at reduced oxygen levels." FBgn0004227 UniProtKB Required for normal vision and courtship behavior in Drosophila. (UniProtKB:Q04047) FBgn0015546 UniProtKB Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity). (UniProtKB:P43248) FBgn0016917 FlyBase Gene Snapshot "Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning." FBgn0032117 Alliance Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in Golgi membrane. Is expressed in adult head; head mesoderm; organism; and trunk mesoderm. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to several human genes including FUT10 (fucosyltransferase 10). FBgn0014135 FlyBase Gene Snapshot branchless (bnl) encodes a fibroblast growth factor (FGF) ligand for the transmembrane tyrosine kinase receptor encoded by btl that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic tracheal migration. FBgn0033809 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A1 (solute carrier family 22 member 1) and SLC22A3 (solute carrier family 22 member 3). FBgn0033810 Alliance Predicted to enable zinc ion binding activity. Orthologous to human CZIB (CXXC motif containing zinc binding protein). FBgn0035964 Alliance "Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase)." FBgn0039348 UniProtKB "May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (UniProtKB:Q9VBP9)" FBgn0039349 Alliance Enables succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). FBgn0002789 Alliance "Predicted to enable actin filament binding activity. Involved in myoblast fusion and regulation of myoblast fusion. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; border follicle cell; embryonic/larval esophageal visceral muscle; and muscle cell. Orthologous to human TAGLN (transgelin); TAGLN2 (transgelin 2); and TAGLN3 (transgelin 3)." FBgn0037719 UniProtKB "Inner nuclear membrane protein (PubMed:15035436, PubMed:24700158). May have a role in maintaining the structural integrity of the nuclear lamina (PubMed:24700158). During pupal development, plays essential and redundant functions with the other LEM domain proteins; MAN1 and Ote (PubMed:24700158). Also has a redundant but important role with Ote in larval development (PubMed:24700158). (UniProtKB:Q709R6)" FBgn0027375 FlyBase Gene Snapshot "RecQ5 helicase (RecQ5) encodes a DNA helicase that maintains genome stability via participation in many nuclear DNA metabolic processes including DNA repair, DNA resolution, and RNA transcription." FBgn0005677 FlyBase Gene Snapshot "dachshund (dac) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by eya and so, and regulates eye, leg, gonad, and brain development." FBgn0035956 FlyBase Gene Snapshot "Dorsocross2 (Doc2) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives." FBgn0038950 Alliance "Predicted to enable zinc ion binding activity. Involved in dsRNA transport. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic proventriculus intermediate layer; gland; and gut section. Orthologous to human ZFPL1 (zinc finger protein like 1)." FBgn0011225 UniProtKB Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle. (UniProtKB:Q01989) FBgn0003701 FlyBase Gene Snapshot "three rows (thr) encodes a protein that, together with the product of Sse, forms the endoprotease separase complex, which cleaves a subunit of the cohesin complex, thereby allowing separation of the sister chromatids." FBgn0038872 UniProtKB "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. Has an essential role in postembryonic development. (UniProtKB:Q86NP2)" FBgn0036180 FlyBase Gene Snapshot Deubiquitinating enzyme A (Duba) encodes a de-ubiquitylating enzyme of the OTU-family that cleaves preferentially K11- and K63-linked poly-ubiquitin chains. Its catalytic activity is required for spermatogenesis. FBgn0004924 FlyBase Gene Snapshot "Topoisomerase 1 (Top1) encodes a topoisomerase with essential functions in cell proliferation during stages of oogenesis, embryogenesis, larva, and pupa." FBgn0004903 UniProtKB Required for spermatogenesis. Could be required to process a specific transcript essential for spermatogenesis. (UniProtKB:Q02926) FBgn0001168 FlyBase Gene Snapshot hairy (hry) encodes a bHLH transcriptional repressor that recruits the corepressor encoded by gro to target promoters. It is a pair-rule gene that contributes to embryonic segmentation and peripheral neurogenesis. FBgn0032369 Alliance Predicted to be involved in cilium assembly and cilium movement. Predicted to be active in motile cilium. Human ortholog(s) of this gene implicated in spermatogenic failure 41. Orthologous to human CFAP70 (cilia and flagella associated protein 70). FBgn0003145 FlyBase Gene Snapshot "paired (prd) is a paired-rule gene that encodes a transcription factor with two independent DNA binding domains, a paired domain and a homeodomain. Its roles include embryonic segmentation, accessory gland development and male fertility." FBgn0000008 FlyBase Gene Snapshot arc (a) encodes a protein involved in eye development. FBgn0000261 FlyBase Gene Snapshot Catalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. FBgn0004169 FlyBase Gene Snapshot "upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere." FBgn0023076 UniProtKB "Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters. (UniProtKB:O61735)" FBgn0001208 FlyBase Gene Snapshot "Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis." FBgn0036165 UniProtKB Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development. (UniProtKB:Q9VTI8) FBgn0020496 FlyBase Gene Snapshot C-terminal Binding Protein (CtBP) encodes a co-repressor which is recruited by repressive transcription factors through a short Pro-X-Asp-Leu-Ser (PXDLS) peptide motif. Its main role is to repress developmental enhancers. FBgn0027841 FlyBase Gene Snapshot "Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones." FBgn0039713 FlyBase Gene Snapshot Ribosomal protein S8 (RpS8) encodes a structural constituent of ribosomes that is involved in larval lymph gland hemopoiesis. FBgn0039738 FlyBase Gene Snapshot "Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat2) encodes an enzyme involved in protein N-linked glycosylation." FBgn0015269 FlyBase Gene Snapshot "Neurofibromin 1 (Nf1) encodes a protein that functions as a GTPase activating protein for the products of Ras85D and Ras64B in the larval and adult nervous system. Loss of Nf1 results in excess Ras-Raf-ERK signaling and to a non-cell-autonomous cAMP/PKA signaling defect. The product of Nf1 contributes to postembryonic growth, learning/memory, and circadian rhythm." FBgn0037746 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including antennal primordium; anterior endoderm; ganglia; head epidermis primordium; and mesoderm." FBgn0037747 UniProtKB "N-alpha-acetyltransferase that acetylates the amino terminal acidic residue of proteins devoid of initiator methionine (PubMed:29581307). Preferentially acts on proteins starting with Asp-Asp-Asp and Glu-Glu-Glu sequences (PubMed:29581307). In vitro, shows high activity towards N-terminal sequences starting with Met-Asp-Glu-Leu, Met-Glu-Glu-Glu and Met-Asp-Asp-Asp (PubMed:29581307). (UniProtKB:Q59DX8)" FBgn0003862 FlyBase Gene Snapshot "trithorax (trx) encodes a chromatin-modifying enzyme involved in gene regulation. It methylates the histone encoded by His3 on Lys-4, promoting its further acetylation. This activity antagonises the epigenetic silencing by Polycomb group proteins. It contributes to axon guidance, eye development and germ cell migration." FBgn0010226 UniProtKB "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:12547198, PubMed:1445191). (UniProtKB:P41043)" FBgn0000577 FlyBase Gene Snapshot "engrailed (en) encodes a homeodomain-containing transcription factor that is essential for posterior compartment identity and for compartment boundary formation and maintenance. It positively regulates the hh gene and negatively regulates the Hedgehog targets encoded by ci, ptc and dpp." FBgn0000028 FlyBase Gene Snapshot abnormal chemosensory jump 6 (acj6) encodes a POU domain transcription factor that acts in odor receptor gene expression and axon targeting of olfactory neurons. FBgn0022710 Alliance Enables adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to human ADCY9 (adenylate cyclase 9). FBgn0012034 UniProtKB Activates acetate so that it can be used for lipid synthesis or for energy generation. (UniProtKB:Q9VP61) FBgn0027866 Alliance Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Predicted to be active in nucleoplasm. Orthologous to human ZNF318 (zinc finger protein 318). FBgn0038201 FlyBase Gene Snapshot Pyrokinin 1 receptor (PK1-R) encodes a seven transmembrane G-protein coupled receptor. It is thought to be a receptor for the neuropeptides encoded by Capa and Lst. It regulates the production and release of insulin. FBgn0045500 FlyBase Gene Snapshot Gustatory receptor 22b (Gr22b) encodes a transmembrane domain protein unrelated to GPCRs that is predicted to mediate response to non-volatile compounds. FBgn0000721 FlyBase Gene Snapshot "foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function." FBgn0034420 Alliance "Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic ventral epidermis; and ganglia. Orthologous to human C2CD2 (C2 calcium dependent domain containing 2) and C2CD2L (C2CD2 like)." FBgn0003218 FlyBase Gene Snapshot retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. FBgn0024836 FlyBase Gene Snapshot "starry night (stan) encodes the seven-pass transmembrane cadherin that controls planar cell polarity, neuronal dendrite morphogenesis, and axon guidance." FBgn0031016 FlyBase Gene Snapshot kekkon 5 (kek5) encodes a transmembrane protein involved in BMP signaling regulation. FBgn0025936 FlyBase Gene Snapshot Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc. FBgn0000578 FlyBase Gene Snapshot "enabled (ena) encodes the sole Drosophila member of the Ena/VASP family. It acts as a processive actin polymerase, stimulating actin addition at the barbed end. It has roles in both epithelial morphogenesis and CNS pathfinding." FBgn0031649 Alliance Predicted to enable monoatomic ion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein). FBgn0032668 Alliance Predicted to enable glycine N-acyltransferase activity. FBgn0041210 FlyBase Gene Snapshot "Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory." FBgn0001269 FlyBase Gene Snapshot "invected (inv) encodes a homeodomain transcription factor that is closely related to, co-expressed with, and functionally redundant with the product of en. Although dispensable in the laboratory, the product of inv is a transcriptional repressor important for segmentation in the embryo and formation of the posterior compartment in imaginal discs." FBgn0027608 Alliance Predicted to enable cadherin binding activity and tubulin binding activity. Predicted to be involved in signal transduction. Predicted to be located in microtubule. Predicted to be active in cytoplasm. Is expressed in adult head. FBgn0039900 Interactive Fly neuromuscular junction - a calcium sensor that suppresses vesicle release - loss of Syt7 converts the normally observed synaptic facilitation response during repetitive stimulation into synaptic depression FBgn0031474 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in adult head. FBgn0025726 FlyBase Gene Snapshot unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. FBgn0051721 FlyBase Gene Snapshot "Tripartite motif containing 9 (Trim9) encodes a ring finger domain-containing E3 ubiquitin ligase that contributes to neurogenesis, axon guidance, eye development and regulation of locomotive behaviour." FBgn0051992 UniProtKB Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. (UniProtKB:Q8SY33) FBgn0028341 FlyBase Gene Snapshot Protein tyrosine phosphatase Meg2 (Ptpmeg2) encodes a phosphatase involved in border follicle cell migration. FBgn0029870 FlyBase Gene Snapshot "Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction." FBgn0035001 FlyBase Gene Snapshot "Sterile20-like kinase (Slik) encodes a member of the Sterile-20 kinase family. It acts via Raf to promote cell proliferation in imaginal disc epithelia. Independently, Slik acts via the product of Moe to support epithelial integrity." FBgn0032666 FlyBase Gene Snapshot CG5758 encodes a predicted secreted protein with beta-Ig-H3/fasciclin domains. CG5758 overexpression causes lethality and wing adhesion defects. FBgn0026533 FlyBase Gene Snapshot Dek (Dek) encodes a DNA binding protein involved in DNA repair and heterochromatin integrity. FBgn0036534 FlyBase Gene Snapshot Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly. FBgn0036144 UniProtKB Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity. (UniProtKB:Q9VTG7) FBgn0033265 FlyBase Gene Snapshot coilin (coil) encodes a protein required for Cajal body formation. FBgn0038139 FlyBase Gene Snapshot "Pyrokinin 2 receptor 2 (PK2-R2) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system)." FBgn0027529 Alliance "Involved in piRNA-mediated retrotransposon silencing by mRNA destabilization and secondary piRNA processing. Located in P granule and perinuclear region of cytoplasm. Is expressed in several structures, including adult brain cell body rind; adult optic lobe; egg chamber; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7)." FBgn0031802 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval dorsal tracheal branch; embryonic/larval tracheal dorsal trunk; embryonic/larval tracheal transverse connective; and tracheal tip cell. FBgn0037234 Alliance "Is expressed in several structures, including dorsal pharyngeal muscle cell; dorsal pharyngeal muscle primordium; embryonic/larval muscle system; ganglia; and somatic muscle primordium." FBgn0030641 Alliance Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human GLTP (glycolipid transfer protein). FBgn0029736 Alliance Predicted to enable GTPase activator activity. Involved in Golgi organization. Is expressed in embryonic/larval garland cell; garland cell primordium; gonad; and organism. Human ortholog(s) of this gene implicated in infantile hypotonia with psychomotor retardation and characteristic facies-3. Orthologous to human TBCK (TBC1 domain containing kinase). FBgn0030662 Alliance Predicted to enable N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1) and CHSY3 (chondroitin sulfate synthase 3). FBgn0035978 FlyBase Gene Snapshot UDP-glucose pyrophosphorylase (UGP) encodes an enzyme that catalyzes the formation of UDP-glucose from UTP and glucose 1-phosphate. UDP-glucose is essential for glycogen biosynthesis and is also a precursor for the synthesis of UDP-glucuronate and UDP-galactose that are used for protein glycosylation. FBgn0031530 UniProtKB "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714, PubMed:18669915). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:12829714). O-glycosylation modification of proteins by this enzyme might be important for cytokinesis (PubMed:20807760). (UniProtKB:Q6WV19)" FBgn0037100 FlyBase Gene Snapshot "Capability receptor (CapaR) encodes a G-protein-coupled receptor for the neuropeptide encoded by Capa, which stimulates fluid secretion in Malpighian tubules, thus acting as a diuretic hormone." FBgn0032957 Alliance Is expressed in embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. FBgn0034417 Alliance "Predicted to enable beta-glucuronidase activity and carbohydrate binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and extraembryonic structure. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta)." FBgn0031294 FlyBase Gene Snapshot IA-2 protein tyrosine phosphatase (IA-2) encodes a protein involved in gut development and insulin-like peptide secretion. FBgn0000542 FlyBase Gene Snapshot echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death. FBgn0050372 FlyBase Gene Snapshot "ArfGAP with SH3 domain, ankyrin repeat and PH domain (Asap) encodes a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye." FBgn0030844 FlyBase Gene Snapshot pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior. FBgn0031536 UniProtKB Involved in ER-Golgi transport. (UniProtKB:Q961G1) FBgn0039675 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). FBgn0039676 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in wing disc. FBgn0020279 FlyBase Gene Snapshot lingerer (lig) encodes a putative RNA binding protein that forms a complex with the products of orb and orb2. Loss of lig results in defects in copulation and short-term memory. FBgn0015777 UniProtKB "This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (UniProtKB:Q24048)" FBgn0020546 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in organism; parasegment 12; parasegment 14; and parasegment 8. FBgn0011998 Alliance Predicted to enable GUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0052547 Alliance Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0029105 Alliance Predicted to enable actin filament binding activity. Predicted to be involved in Rho protein signal transduction. Is expressed in adult head; embryonic antennal sense organ; embryonic brain; and larval ventral nerve cord. Orthologous to human CTNNAL1 (catenin alpha like 1). FBgn0038570 FlyBase Gene Snapshot "Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis." FBgn0038571 Alliance "Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane and tail-anchored membrane protein insertion into ER membrane. Predicted to be part of BAT3 complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; mesoderm; and visceral muscle primordium. Orthologous to several human genes including UBL4A (ubiquitin like 4A)." FBgn0039308 Alliance Predicted to enable ecdysteroid 22-kinase activity. FBgn0039309 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0036170 Alliance "Is expressed in several structures, including amnioserosa; circulatory system primordium; embryonic/larval garland cell; larval foregut atrium; and yolk nucleus." FBgn0031039 FlyBase Gene Snapshot Shawn (Shawn) encodes a mitochondrial carrier involved in metal homeostasis. FBgn0031038 Alliance Predicted to enable glutathione transmembrane transporter activity. Predicted to be involved in glutathione import into mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to several human genes including SLC25A40 (solute carrier family 25 member 40). FBgn0053155 Alliance Involved in larval lymph gland hemopoiesis. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. FBgn0050481 Alliance Predicted to be a structural constituent of ribosome. Involved in larval lymph gland hemopoiesis. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL53 (mitochondrial ribosomal protein L53). FBgn0013576 FlyBase Gene Snapshot "mustard (mtd) encodes an ecdysone-regulated late puff protein. A isoform including only the C-terminal with a TLDc domain enters the nucleus. This isoform increases intestinal stem cell division and suppresses expression of the antimicrobial peptide encoded by DptA at the transcriptional level, independent of IMD pathway signaling." FBgn0043002 FlyBase Gene Snapshot "Chromatin accessibility complex 14kD protein (Chrac-14) encodes a subunit of the chromatin accessibility complex, which is an evolutionary conserved nucleosome sliding enzyme. It is also important for DNA damage response." FBgn0002887 FlyBase Gene Snapshot mutagen-sensitive 201 (mus201) encodes a protein involved in UV-damage excision repair. FBgn0053095 Alliance Is expressed in organism. FBgn0065047 FlyBase Gene Snapshot C/D box small nucleolar RNA 11b (snoRNA:CD11b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1005 in 28SrRNA:CR45844. FBgn0032538 Alliance "Predicted to enable chitin binding activity. Predicted to be a structural constituent of chitin-based cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; and embryonic hypopharynx. Orthologous to human ZNF512B (zinc finger protein 512B)." FBgn0065080 FlyBase Gene Snapshot C/D box small nucleolar RNA 12 (snoRNA:CD12) is predicted to encode a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation in rRNA. FBgn0065070 FlyBase Gene Snapshot C/D box small nucleolar RNA 19 (snoRNA:CD19) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3412 in 28SrRNA:CR45844. FBgn0053639 Alliance Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in adult head. FBgn0029948 Alliance Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0035253 Alliance "Involved in alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2)." FBgn0064115 UniProtKB Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (UniProtKB:Q86BL4) FBgn0004407 FlyBase Gene Snapshot "DNA polymerase gamma subunit 2 (PolG2) encodes the accessory subunit of mitocondrial DNA polymerase gamma, which is responsible for the replication and repair of the mitochondrial genome." FBgn0053653 UniProtKB "Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. (UniProtKB:Q9NHE5)" FBgn0032364 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme and ciliary basal body. FBgn0032365 Alliance Predicted to be involved in cristae formation. Predicted to be part of MICOS complex. Predicted to be active in mitochondrial crista junction. FBgn0034618 FlyBase Gene Snapshot "Glycogen debranching enzyme (Agl) encodes an enzyme that transfers three glucose residues from the four-residue glycogen branch to a nearby branch (glucosyltransferase activity) and cleaves the remaining alpha-1,6 linked glucose (amylo-alpha-1,6-glucosidase activity), producing a linear chain of glycogen. It converts the branched glycogen structure into a linear one, which can be cleaved further by glycogen phosphorylase (Glyp) and thus is involved in glycogen catabolism (glycogenolysis)." FBgn0037555 UniProtKB "Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. (UniProtKB:Q8I8V0)" FBgn0000153 FlyBase Gene Snapshot Acidic amino acid decarboxylase (Adc) encodes an aspartate 1-decarboxylase. Mutations of Adc result in viable flies with a cuticular melanization phenotype. FBgn0015609 UniProtKB Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information. (UniProtKB:O15943) FBgn0001223 FlyBase Gene Snapshot "Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance." FBgn0001228 Alliance Is expressed in organism and testis. Orthologous to human TSTD1 (thiosulfate sulfurtransferase like domain containing 1). FBgn0065046 FlyBase Gene Snapshot C/D box small nucleolar RNA 11c (snoRNA:CD11c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0065071 FlyBase Gene Snapshot C/D box small nucleolar RNA 18 (snoRNA:CD18) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2598 in 28SrRNA:CR45844. FBgn0033380 Alliance Predicted to enable RNA binding activity. Predicted to be involved in snRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human PHAX (phosphorylated adaptor for RNA export). FBgn0061359 Alliance "Predicted to enable mevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in peroxisome. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase)." FBgn0061360 Alliance "Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; gut section; and mesoderm. Orthologous to human BOLA2 (bolA family member 2) and BOLA2B (bolA family member 2B)." FBgn0053673 Alliance Predicted to be active in membrane. FBgn0065053 FlyBase Gene Snapshot C/D box small nucleolar RNA 15 (snoRNA:CD15) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C1831 in 18SrRNA:CR45838. FBgn0039452 Alliance Predicted to enable chitin binding activity. FBgn0067622 Alliance "Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in embryonic/larval somatic muscle cell; head mesoderm; organism; somatic muscle primordium; and trunk mesoderm. Orthologous to human COMMD5 (COMM domain containing 5)." FBgn0032240 Alliance "Predicted to enable U6 snRNA binding activity. Predicted to be involved in P-body assembly and spliceosomal snRNP assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP. Predicted to be active in P-body. Is expressed in embryonic/larval somatic muscle cell; head mesoderm; organism; somatic muscle primordium; and trunk mesoderm. Orthologous to human LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)." FBgn0029859 Alliance Is expressed in spermatozoon. FBgn0029860 Alliance Is expressed in eye. FBgn0029504 FlyBase Gene Snapshot Checkpoint suppressor 1-like (CHES-1-like) encodes a transcription factor that regulates the division of cardiac progenitor cells and dpp transcription in testis. FBgn0041775 FlyBase Gene Snapshot trailer hitch (tral) encodes a protein required for oocyte dorsoventral patterning via actin and microtubule cytoskeleton organization. FBgn0003507 FlyBase Gene Snapshot "serpent (srp) encodes an important transcription factor for the proper development of mesodermal derivatives such as fat body, hemocytes and limph gland. It contributes to endoderm development, hemopoiesis and glucose metabolism." FBgn0053680 Alliance Predicted to be active in extracellular space. FBgn0002524 FlyBase Gene Snapshot lace (lace) encodes a serine C-palmitoyltransferase involved in sphingolipid biosynthesis. FBgn0037716 UniProtKB "RNA-binding protein that protects nascent transcripts containing intronic transposable sequences, known as INE-1, from being degraded by DIP1 (PubMed:31730657). Modulates DIP1 activity by repressing its sumoylation levels (PubMed:31730657). This ensures that intronic sequences will be degradated only after splicing (PubMed:31730657). In the ovaries, regulates germline stem cells (GSCs) self-renewal by repressing the expression of the GSC differentiation-promoting factor Rga (PubMed:29887366). (UniProtKB:Q9VHB0)" FBgn0002632 Alliance "Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including embryonic/larval midgut; ganglia; myoblast; presumptive embryonic/larval system; and section of wing margin." FBgn0002522 FlyBase Gene Snapshot "labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut." FBgn0065098 Alliance "Predicted to enable ribonuclease MRP activity. Involved in endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA). Located in nucleolus." FBgn0039157 Alliance "Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human MYO1A (myosin IA) and MYO1B (myosin IB)." FBgn0011676 UniProtKB "Catalyzes the conversion of L-arginine to L-citrulline producing nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:12804606, PubMed:7568075). Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full-length protein and serve as dominant negative inhibitors of the enzyme activity. (UniProtKB:Q27571)" FBgn0065073 FlyBase Gene Snapshot C/D box small nucleolar RNA 13 (snoRNA:CD13) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C2744 in 28SrRNA:CR45844. FBgn0037913 FlyBase Gene Snapshot fatty acid binding protein (fabp) encodes a protein involved in long term memory. FBgn0037912 FlyBase Gene Snapshot "scheggia (sea) encodes a carrier protein of the inner mitochondrial membrane that plays a central role in fatty acid and sterol biosynthesis. It catalyses an electroneutral exchange of citrate for another tricarboxylate, a dicarboxylate (L-malate), or phosphoenolpyruvate across the inner mitochondrial membrane. The product of sea is also required to prevent chromosome breaks." FBgn0032888 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in adult thoracic sensillum and appendage. FBgn0051221 Alliance "Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut primordium; larval ventral nerve cord; and lateral cord surface glial cell." FBgn0031403 Alliance Predicted to be involved in post-embryonic development. Human ortholog(s) of this gene implicated in Temtamy syndrome. Orthologous to human C12orf57 (chromosome 12 open reading frame 57). FBgn0026239 FlyBase Gene Snapshot "GUK-holder (gukh) encodes a protein that regulates spindle orientation in neuroblasts via direct interaction with microtubules and the tumor suppressors encoded by dlg1 and scrib. It also plays a role in polarizing fate determinants, such as the product of mira." FBgn0051016 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in sexual reproduction. Predicted to be active in endoplasmic reticulum. FBgn0052423 FlyBase Gene Snapshot "alan shepard (shep) encodes an evolutionarily conserved RNA/DNA binding protein that regulates alternative splicing and gypsy insulator activities. It regulates neural development during the embryonic and larval stages, and neuronal remodeling during metamorphosis." FBgn0033884 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be active in nucleus. Orthologous to human RNF25 (ring finger protein 25). FBgn0040233 FlyBase Gene Snapshot CENP-ana (cana) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment. FBgn0052831 Alliance Predicted to be part of MLL1 complex and NURF complex. Is expressed in organism. Orthologous to human C17orf49 (chromosome 17 open reading frame 49). FBgn0053696 FlyBase Gene Snapshot CNMamide Receptor (CNMaR) encodes a G-protein coupled receptor for the neuropeptide encoded by CNMa. FBgn0052843 FlyBase Gene Snapshot Diuretic hormone 31 Receptor (Dh31-R) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathwayS. FBgn0016919 FlyBase Gene Snapshot "no mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits." FBgn0036783 FlyBase Gene Snapshot "Chemosensory protein A 75a (CheA75a) encodes a protein which interacts with the fungal pathogen spore surface protein Mcdc9 to trigger fly hygienic grooming, the behavioral defense against fungal parasite infection." FBgn0001624 UniProtKB "During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (UniProtKB:P31007)" FBgn0067903 Alliance Involved in defense response to other organism. Located in extracellular region. FBgn0039378 Alliance "Enables alpha-1,4-N-acetylgalactosaminyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in membrane. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)) and A4GNT (alpha-1,4-N-acetylglucosaminyltransferase)." FBgn0064116 Alliance "Predicted to enable fatty-acyl-CoA binding activity. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; mesoderm; and sense organ. Orthologous to human ACBD6 (acyl-CoA binding domain containing 6)." FBgn0064117 Alliance "Predicted to enable mRNA binding activity. Predicted to be active in nucleus. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; gut section; and mesoderm. Orthologous to human SLIRP (SRA stem-loop interacting RNA binding protein)." FBgn0065051 Alliance Located in Cajal body. FBgn0260458 UniProtKB Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response. (UniProtKB:Q9GN97) FBgn0044419 FlyBase Gene Snapshot "Pmi (Pmi) encodes a ubiquitous protein of the mitochondrial inner membrane that negatively controls the biogenesis of cristae membrane. Pmi-dependent cristae alterations are associated with impaired oxidative metabolism, abnormal mitochondrial shape/size, defective mitochondrial transport in neurons, and lead to stress-induced paralysis in adult flies." FBgn0046874 Alliance "Is expressed in several structures, including adult head; amnioserosa; dorsal sensory complex proper primordium; spermatozoon; and ventral midline of embryo." FBgn0042182 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum. FBgn0064126 Alliance "Predicted to be involved in glucose homeostasis and intracellular protein transport. Predicted to be active in cytoplasm; nucleus; and vesicle membrane. Human ortholog(s) of this gene implicated in alveolar soft part sarcoma. Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2A4, UBX domain containing)." FBgn0260439 FlyBase Gene Snapshot "Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization." FBgn0065057 Alliance Enables snRNA 2'-O-ribose methylation guide activity. Located in Cajal body. FBgn0014163 UniProtKB "Together with Abl, involved in embryonic axonal development. (UniProtKB:Q95RI5)" FBgn0040076 UniProtKB Catalyzes the dephosphorylation of tyrosine phosphorylated proteins and low-MW aryl phosphates (PubMed:10675607). Can contribute to the regulation of a variety of developmental processes (PubMed:10675607). (UniProtKB:P82891) FBgn0051469 Alliance "Enables protein arginine phosphatase activity. Predicted to be located in cytoplasm and extracellular exosome. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1)." FBgn0040077 UniProtKB "Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. (UniProtKB:P82890)" FBgn0037550 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Part of Prp19 complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human ISY1 (ISY1 splicing factor homolog) and ISY1-RAB43 (ISY1-RAB43 readthrough)." FBgn0036713 FlyBase Gene Snapshot "Myoinhibiting peptide precursor (Mip) encodes a member of the allatostatin family of peptides - specifically, the B-type allatostatins. Mip can act as a neuropeptide, neurohormone, and/or a hormone to regulate the nervous system and metabolic processes." FBgn0014857 UniProtKB "Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:C0HL66)" FBgn0052269 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in salivary gland body primordium; spermatozoon; and stomatogastric nervous system primordium. FBgn0052270 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in salivary gland body primordium and stomatogastric nervous system primordium. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLK10 (kallikrein related peptidase 10). FBgn0034518 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36); PRSS53 (serine protease 53); and TMPRSS4 (transmembrane serine protease 4). FBgn0034519 Alliance Predicted to be part of BORC complex. Orthologous to human BORCS7 (BLOC-1 related complex subunit 7). FBgn0051438 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg. FBgn0003742 FlyBase Gene Snapshot "transformer 2 (tra2) is a sex-determining gene that encodes a pre-mRNA binding protein. It regulates the alternative splicing of several mRNAs including those from key regulators of sexual differentiation, dsx and fru, and Taf1, which encodes a TFIID component." FBgn0036789 FlyBase Gene Snapshot Allatostatin C receptor 2 (AstC-R2) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. FBgn0035486 UniProtKB One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. (UniProtKB:Q9VZJ6) FBgn0045476 UniProtKB One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast. (UniProtKB:P83296) FBgn0038880 FlyBase Gene Snapshot "SIFamide receptor (SIFaR) encodes a G-protein coupled peptide receptor involved in both the neuropeptide and the G-protein coupled receptor signaling pathways. It is required for sensory perception of pain, determination of lifespan and sexual behavior." FBgn0029890 Alliance Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). FBgn0029891 FlyBase Gene Snapshot "PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain." FBgn0029888 Alliance "Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8)." FBgn0005672 FlyBase Gene Snapshot "spitz (spi) encodes the cardinal Egfr ligand that is produced as a transmembrane precursor and processed by the products of S and rho. Its roles include growth regulation, cell survival and developmental patterning." FBgn0001099 Alliance Is expressed in nurse cell; oocyte; spermatocyte; and testis. Orthologous to human DGCR6 (DiGeorge syndrome critical region gene 6) and DGCR6L (DiGeorge syndrome critical region gene 6 like). FBgn0051324 Alliance Involved in negative regulation of DNA-templated transcription and negative regulation of circadian rhythm. Is expressed in embryonic brain; embryonic/larval crystal cell; embryonic/larval midgut; and larval ventral nerve cord. FBgn0053774 UniProtKB "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. (UniProtKB:A1Z7U3)" FBgn0035497 Alliance "Predicted to be involved in cytoskeleton organization. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic ventral epidermis; embryonic/larval midgut primordium; and larval foregut atrium. Human ortholog(s) of this gene implicated in axial spondylometaphyseal dysplasia. Orthologous to human CFAP410 (cilia and flagella associated protein 410)." FBgn0065066 FlyBase Gene Snapshot C/D box small nucleolar RNA 14 (snoRNA:CD14) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2634 in 28SrRNA:CR45844. FBgn0061362 Alliance Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III and termination of RNA polymerase III transcription. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K). FBgn0061361 Alliance Predicted to enable L-threonylcarbamoyladenylate synthase and tRNA binding activity. Predicted to be involved in regulation of translational fidelity and tRNA threonylcarbamoyladenosine modification. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). FBgn0039582 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:Q9VAW0)" FBgn0050462 FlyBase Gene Snapshot "ste24c prenyl protease type I (ste24c) encodes a protein that, along with the products of ste24a and ste24b, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24c plays an essential role in the male germline." FBgn0050461 FlyBase Gene Snapshot CG30461 encodes a protein that is likely a recent partial duplicate of the type I prenyl protease encoded by ste24c. FBgn0035197 Alliance Is expressed in spermatozoon. FBgn0035198 Alliance Is expressed in spermatozoon. FBgn0041720 Alliance "Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in Cajal body." FBgn0025643 Alliance Is expressed in embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic ventral apodeme; embryonic ventral epidermis; and gut section. FBgn0020912 FlyBase Gene Snapshot Ptx1 (Ptx1) encodes a paired-like homeobox transcription factor expressed during embryogenesis and in the adult digestive tract. It is strongly expressed in the middle midgut (copper cell region) where it is required for local stem cell quiescence and proper function of this region. FBgn0063923 Alliance "Predicted to enable serine-type endopeptidase inhibitor activity. Located in extracellular region and mitochondrion. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and gastric caecum." FBgn0035240 Alliance Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Predicted to contribute to oxoglutarate dehydrogenase (NAD+) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in oxoglutarate dehydrogenase deficiency. Orthologous to human OGDH (oxoglutarate dehydrogenase). FBgn0065058 FlyBase Gene Snapshot C/D box small nucleolar RNA 21 (snoRNA:CD21) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G393 in 18SrRNA:CR45838. FBgn0051072 FlyBase Gene Snapshot lysosomal enzyme receptor protein (Lerp) encodes a protein involved in lysosome function and autophagy. FBgn0032077 Alliance Predicted to enable nucleoside triphosphate diphosphatase activity. Is expressed in adult head; embryonic proventriculus inner layer; embryonic/larval midgut primordium; and gut section. Orthologous to human ASMTL (acetylserotonin O-methyltransferase like). FBgn0032076 Alliance Predicted to enable argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to be active in cytosol. Is expressed in anterior midgut primordium; embryonic proventriculus; embryonic proventriculus inner layer; embryonic/larval midgut; and posterior midgut primordium. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). FBgn0033652 FlyBase Gene Snapshot "thisbe (ths) encodes is a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival." FBgn0001235 FlyBase Gene Snapshot "homothorax (hth) encodes a homeodomain transcription factor that allows the nuclear import of the protein encoded by exd by direct binding. The complex hth-exd are Hox cofactors but also have additional Hox-independent functions such as in antennal development, proximal appendages patterning, and cell division promotion of the undifferentiated eye field." FBgn0000056 Alliance "Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval midgut; ganglia; primordial germ cell; and visceral mesoderm derivative." FBgn0053096 Alliance "Enables serine hydrolase activity. Located in plasma membrane. Is expressed in adult head and organism. Orthologous to several human genes including ABHD17A (abhydrolase domain containing 17A, depalmitoylase)." FBgn0053801 Alliance "Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member)." FBgn0053803 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0051617 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0051618 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0051613 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053804 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053806 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053807 Alliance "Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member)." FBgn0053808 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053809 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053810 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053812 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053813 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053814 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053815 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053816 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053817 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053818 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053819 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053820 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053821 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053822 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053823 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053824 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053825 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053826 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053827 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053828 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053829 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053830 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053831 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053832 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053833 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053834 Alliance "Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member)." FBgn0053835 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053836 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053837 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053838 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053839 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053840 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053841 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053842 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053843 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053844 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053845 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053846 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053847 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053848 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053849 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053850 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053851 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053852 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053853 Alliance Predicted to enable nucleosomal DNA binding activity. Predicted to be involved in heterochromatin formation. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H2AC11 (H2A clustered histone 11); H2AC12 (H2A clustered histone 12); and H2AC13 (H2A clustered histone 13). FBgn0053854 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053855 Alliance "Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member)." FBgn0053856 Alliance Predicted to enable DNA binding activity. Predicted to be involved in chromatin organization. Predicted to be part of nucleosome. Orthologous to several human genes including H2AC11 (H2A clustered histone 11); H2AC12 (H2A clustered histone 12); and H2AC13 (H2A clustered histone 13). FBgn0053857 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053858 Alliance "Predicted to enable chromatin DNA binding activity. Predicted to be involved in nucleosome assembly. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member)." FBgn0053859 Alliance Predicted to enable DNA binding activity. Predicted to be involved in chromatin organization. Predicted to be part of nucleosome. Orthologous to several human genes including H2AC11 (H2A clustered histone 11); H2AC12 (H2A clustered histone 12); and H2AC13 (H2A clustered histone 13). FBgn0053860 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053861 Alliance "Predicted to enable chromatin DNA binding activity. Predicted to be involved in nucleosome assembly. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member)." FBgn0053862 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053863 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053864 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0053865 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0053866 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0053868 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053869 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053870 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053871 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053872 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053873 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053874 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053875 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053876 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053877 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053878 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053879 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053880 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053881 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053882 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053883 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053884 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053885 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053886 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053887 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053888 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053889 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053890 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053891 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053892 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053893 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053894 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053895 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053896 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053897 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053898 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053899 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053900 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053901 FlyBase Gene Snapshot His4:CG33901 (His4:CG33901) encodes a histone H4 replacement variant that is part of the nucleosome core. It is the predominant histone H4 in non-dividing cells. Its amino acid sequence is identical to the cell-cycle regulated histone encoded by His4. FBgn0053902 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053903 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053904 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053905 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053906 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053907 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053908 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0051611 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0061209 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0053909 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0053910 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0028991 FlyBase Gene Snapshot "sequoia (seq) encodes a pan-neuronally expressed zinc-finger transcription factor that governs dendrite and axon outgrowth. It is necessary for the proper development of tracheal branches and dendritic branches of multidendritic neurons, as well as development of the R8 cell in eye development." FBgn0025455 FlyBase Gene Snapshot "Cyclin T (CycT) encodes a gene that, together with Cdk9, form the Positive Transcription Elongation Factor b (P-TEFb) complex that is needed to release RNA polymerase II into productive transcription elongation." FBgn0038683 Alliance "Predicted to enable protein-folding chaperone binding activity. Involved in cellular response to hypoxia. Predicted to be part of PAM complex, Tim23 associated import motor. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and adult heart. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44)." FBgn0033628 Alliance Is expressed in dorsal sensory complex proper primordium; embryonic dorsal epidermis; embryonic head sensory system; sensory nervous system primordium; and ventral sensory complex primordium. FBgn0033739 Alliance "Predicted to be a structural constituent of muscle. Involved in maintenance of presynaptic active zone structure and regulation of neurotransmitter secretion. Located in neuromuscular junction. Is expressed in several structures, including adult head; embryonic epidermis; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; and ganglia. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to several human genes including DTNA (dystrobrevin alpha)." FBgn0034081 Alliance Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human DMAC2L (distal membrane arm assembly component 2 like). FBgn0029175 UniProtKB "Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. (UniProtKB:Q9Y169)" FBgn0027358 UniProtKB "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity). (UniProtKB:Q9Y0V3)" FBgn0031041 Alliance Predicted to enable L-seryl-tRNA(Sec) kinase activity and tRNA binding activity. Is expressed in organism. Orthologous to human PSTK (phosphoseryl-tRNA kinase). FBgn0003435 FlyBase Gene Snapshot "smooth (sm) encodes an RNA binding, heterogeneous nuclear ribonucleoprotein involved in axon guidance, mRNA processing, chemosensation, determination of lifespan and feeding behavior." FBgn0024251 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human BBX (BBX high mobility group box domain containing)." FBgn0024182 UniProtKB "Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (UniProtKB:Q9VRH6)" FBgn0031455 UniProtKB Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis (PubMed:20015953). May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity). (UniProtKB:Q9VQF9) FBgn0031454 Alliance Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and protein methyltransferase activity. Predicted to be involved in methylation. Predicted to be part of eRF1 methyltransferase complex. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1). FBgn0038032 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult head. FBgn0038033 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult heart. FBgn0051224 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human FIZ1 (FLT3 interacting zinc finger 1); ZBTB44 (zinc finger and BTB domain containing 44); and ZNF618 (zinc finger protein 618)." FBgn0065048 FlyBase Gene Snapshot C/D box small nucleolar RNA 11a (snoRNA:CD11a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1005 in 28SrRNA:CR45844. FBgn0011640 FlyBase Gene Snapshot "lark (lark) encodes an essential RNA-binding protein of the RNA recognition motif (RRM) class. It is implicated in both RNA splicing and translational control. It contributes to oogenesis, tissue development and circadian behavior." FBgn0065099 Alliance Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Part of 7SK snRNP. FBgn0053926 Alliance Involved in defense response to virus. FBgn0067311 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg. FBgn0024293 Alliance "Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); retinal vascular disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1)." FBgn0038888 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg; prothoracic leg taste bristle; and third segment of antenna. FBgn0065076 FlyBase Gene Snapshot C/D box small nucleolar RNA 17 (snoRNA:CD17) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0033564 Alliance Predicted to enable ATP hydrolysis activity; protein transporter activity; and ubiquitin-modified protein reader activity. Involved in peroxisome organization. Located in peroxisome. Is expressed in embryonic cortex and yolk. Human ortholog(s) of this gene implicated in Heimler syndrome 2; peroxisomal biogenesis disorder; and peroxisome biogenesis disorder 4A. Orthologous to human PEX6 (peroxisomal biogenesis factor 6). FBgn0061356 Alliance Predicted to enable (S)-2-hydroxy-acid oxidase activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be located in peroxisome. Predicted to be active in peroxisomal matrix. Is expressed in adult head and adult heart. Orthologous to several human genes including HAO1 (hydroxyacid oxidase 1). FBgn0066304 UniProtKB "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity). (UniProtKB:Q2MGL3)" FBgn0066303 Alliance Predicted to be involved in intracellular calcium ion homeostasis. Predicted to be active in endoplasmic reticulum. Is expressed in organism. Orthologous to human TMEM203 (transmembrane protein 203). FBgn0260466 UniProtKB "Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage (By similarity). (UniProtKB:Q9VDQ0)" FBgn0064119 Alliance Predicted to enable citrate transmembrane transporter activity and succinate transmembrane transporter activity. Predicted to be involved in citrate transport; succinate transport; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A2 (solute carrier family 13 member 2). FBgn0002709 FlyBase Gene Snapshot meiotic 218 (mei-218) is encoded on the same mRNA as the product of mei-217. The products of mei-217 and mei-218 interact physically and are involved in meiotic recombination. FBgn0028581 FlyBase Gene Snapshot mei-217 (mei-217) is encoded on the same mRNA as the product of mei-218. The products of mei-217 and mei-218 interact physically and are involved in meiotic recombination. FBgn0063127 FlyBase Gene Snapshot long non-coding RNA:CR33938 (lncRNA:CR33938) is highly expressed in the distal cells of the third instar larval leg disc and has potential roles in regulating distal leg development. FBgn0062961 Alliance Involved in positive regulation of signal transduction and response to bacterium. Is active in nucleus. FBgn0047334 FlyBase Gene Snapshot BG642312 (BG642312) encodes a peptide produced in the male accessory glands and transferred to females during mating. FBgn0029153 Alliance Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Is expressed in spermatozoon. FBgn0029154 Alliance Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. FBgn0004507 FlyBase Gene Snapshot Glycogen phosphorylase (Glyp) encodes an enzyme that catalyzes the phosphorolytic cleavage of glycogen to produce glucose 1-phosphate and thus plays an essential role in glycogen catabolism (glycogenolysis). FBgn0066084 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm and nucleolus. Colocalizes with nuclear chromosome. FBgn0083167 Alliance "Predicted to be part of mitochondrial proton-transporting ATP synthase complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 6. Orthologous to human ATP5MK (ATP synthase membrane subunit k)." FBgn0031414 UniProtKB Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system. (UniProtKB:A0A1F4) FBgn0034903 FlyBase Gene Snapshot "sol narae (sona) encodes a member of the ADAMTS family of proteases secreted to the extracellular matrix. It is involved in Wg signaling by promoting the secretion of the product of wg, and is essential for development and growth." FBgn0001297 FlyBase Gene Snapshot "kayak (kay) encodes a transcription factor involved in multiple biological processes including cell polarity, wound healing, germ cell and eye development and cell cycle." FBgn0032763 Alliance Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. FBgn0024963 UniProtKB "Glutamate-gated chloride channel subunit (PubMed:11095718, PubMed:8702744). Together with Gamma-aminobutyric acid receptor Rdl, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons (PubMed:31535971). ACTIVITY REGULATION: Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration (PubMed:11095718, PubMed:8702744). Inhibited by picrotoxin (PubMed:31535971). (UniProtKB:Q94900)" FBgn0036210 Alliance Predicted to be involved in fatty acid metabolic process and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7). FBgn0032536 Alliance "Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2)." FBgn0020880 Alliance "Predicted to enable serine-type endopeptidase activity. Involved in synaptic target recognition. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic large intestine; embryonic precursor of adult hindgut; embryonic salivary gland duct; and gut section." FBgn0032812 FlyBase Gene Snapshot "Hakai (Hakai) encodes a ring finger type E3 ubiquitin ligase that associates with the cadherin encoded by shg. It is essential for organismal viability and embryonic morphogenesis, but is dispensable for cell viability and proliferation." FBgn0001149 UniProtKB "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:20417639, PubMed:22082028). Has DDT dehydrochlorinase activity (PubMed:20417639). May be involved in detoxification (PubMed:22082028). (UniProtKB:P20432)" FBgn0035766 UniProtKB "Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. (UniProtKB:Q9VS50)" FBgn0034314 FlyBase Gene Snapshot no poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. FBgn0034317 Alliance Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. FBgn0053958 Alliance Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. FBgn0034315 Alliance Predicted to be involved in hematopoietic progenitor cell differentiation. Is expressed in adult head and organism. Orthologous to human ARMC6 (armadillo repeat containing 6). FBgn0052803 FlyBase Gene Snapshot "Lipid droplet assembly factor 1 (Ldaf1) encodes a protein involved in lipid droplet biogenesis. It is linked to the Seipin protein and altering its abundance affects lipid droplet size, number and overall lipid storage amounts." FBgn0031191 FlyBase Gene Snapshot "Centriolar coiled coil protein 110kDa (Cp110) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It seems to prevent the centriole microtubules from extending beyond the distal end of the centriole. It interacts with the product of Cep97, another protein localized to the distal end of the centrioles." FBgn0031930 Alliance Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA5 (carboxypeptidase A5). FBgn0038714 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0017579 FlyBase Gene Snapshot "Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles." FBgn0031220 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4). FBgn0025388 UniProtKB "In asymmetrically dividing germline stem cells (GSCs), plays a critical role in ensuring centrosome duplication, which is essential for the production of centrosomes and centrioles in all downstream germ cells (PubMed:32965218). Might recruit SAK for daughter centriole duplication (PubMed:32965218). (UniProtKB:Q5BI31)" FBgn0025387 Alliance Colocalizes with ciliary basal body. FBgn0000152 FlyBase Gene Snapshot "Abnormal X segregation (Axs) encodes a member of transmembrane proteins with calcium-activated chloride activity. Axs product localizes to a membranous sheath that surrounds the oocyte meiosis I spindle. A dominant mutation in Axs results in barrel-shaped meiosis I spindles, cell cycle defects, and missegregation of nonexchange chromosomes in oocytes." FBgn0003900 FlyBase Gene Snapshot "twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells." FBgn0036685 Alliance Predicted to be involved in establishment of meiotic spindle orientation. Predicted to be located in condensed chromosome and spindle pole. Orthologous to human CCDC6 (coiled-coil domain containing 6). FBgn0030778 Alliance "Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. Is expressed in several structures, including adult head; embryonic anal pad; embryonic hypopharynx; embryonic precursor of adult foregut; and gut section. Orthologous to human CPM (carboxypeptidase M)." FBgn0013799 UniProtKB Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd. (UniProtKB:Q24180) FBgn0032515 FlyBase Gene Snapshot "loquacious (loqs) encodes a double-stranded RNA binding protein with multiple splicing isoforms. loqs-PB and loqs-PA associate with the product of Dcr-1 to facilitate processing of precursor miRNA into mature miRNA, whereas loqs-PD interacts with the product of Dcr-2 to enhance processing of dsRNA into siRNA." FBgn0052202 Alliance Predicted to enable DNA binding activity. Predicted to be involved in apoptotic signaling pathway and positive regulation of apoptotic process. Predicted to be part of Ino80 complex. Orthologous to human TFPT (TCF3 fusion partner). FBgn0050280 Alliance Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to several human genes including FIBCD1 (fibrinogen C domain containing 1) and MFAP4 (microfibril associated protein 4). FBgn0033712 Alliance Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human MTIF3 (mitochondrial translational initiation factor 3). FBgn0027094 UniProtKB Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (UniProtKB:Q9VLM8) FBgn0039648 Alliance Predicted to be active in membrane. FBgn0035426 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be located in cytoplasm. FBgn0032551 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0031322 Alliance Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to several human genes including DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). FBgn0000277 FlyBase Gene Snapshot "Cecropin A2 (CecA2) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level by the immune deficiency pathway." FBgn0035945 Alliance Predicted to enable protein phosphatase binding activity. Predicted to be involved in negative regulation of autophagy and phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human MTMR9 (myotubularin related protein 9). FBgn0031575 FlyBase Gene Snapshot "Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole." FBgn0034165 Alliance Predicted to enable lysozyme activity. FBgn0002631 UniProtKB Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (UniProtKB:P13096) FBgn0034009 FlyBase Gene Snapshot "CG8155 encodes a Rab GTPase activator of the Rab signaling pathway. It's involved in border follicle cell migration, regulation of GTPase activity, intracellular trafficking of vesicles and determination of lifespan." FBgn0031995 UniProtKB "Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity). (UniProtKB:Q9VLS1)" FBgn0004047 UniProtKB "Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Vitellogenins and their receptor yl/yolkless are required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex (PubMed:33891588). (UniProtKB:P06607)" FBgn0034415 Alliance Predicted to enable thioredoxin-dependent peroxiredoxin activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). FBgn0067317 FlyBase Gene Snapshot Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation. FBgn0014464 Alliance Predicted to be a structural constituent of egg chorion. Involved in chorion-containing eggshell formation. Predicted to be located in egg chorion. Is expressed in floor cell; follicle cell; and main body follicle cell. FBgn0025632 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in embryonic/larval visceral muscle cell and organism. Orthologous to human GPR84 (G protein-coupled receptor 84). FBgn0011837 FlyBase Gene Snapshot "Tis11 zinc finger protein (Tis11) encodes a protein with three splice isoforms, all of which have the major attributes of members of the tristetraprolin (TTP) family of RNA binding and destabilizing proteins. Tis11 knockout and knock-down flies exhibit relatively minor delays in eclosion associated with accumulation of many putative mRNA targets." FBgn0036916 Alliance Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC6 (exosome component 6). FBgn0011272 FlyBase Gene Snapshot Ribosomal protein L13 (RpL13) encodes a ribosomal structural constituent. FBgn0053964 Alliance Predicted to enable methyltransferase activity. Orthologous to human METTL25 (methyltransferase like 25). FBgn0033453 UniProtKB "Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:29924997, PubMed:29934091, PubMed:30119996, PubMed:33262294, PubMed:34261127, PubMed:34261128). Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L.monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish) (PubMed:29924997). Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGlr1 and cGlr2 in response to RNA virus in the cytosol (PubMed:34261127, PubMed:34261128). Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP (PubMed:34261127). Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish) (PubMed:34261127, PubMed:34261128). Activated in brain in response to Zika virus infection, leading to autophagy (PubMed:29934091). (UniProtKB:A0A0B4LFY9)" FBgn0010406 Alliance "Predicted to enable RNA endonuclease activity. Involved in sexual reproduction. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including adult heart; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2)." FBgn0036493 Alliance Predicted to enable L-arginine transmembrane transporter activity; L-lysine transmembrane transporter activity; and L-ornithine transmembrane transporter activity. Predicted to be involved in L-arginine import across plasma membrane and L-ornithine transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Orthologous to human SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). FBgn0003028 FlyBase Gene Snapshot "ovo (ovo) encodes a Zn finger transcription factor, with several isoforms acting as repressor or activator. It is involved in epidermis differentiation, under the control of Wnt and EGFR signaling pathways and Hox factors, as well as female germline differentiation and sex determination." FBgn0020372 Alliance Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; embryonic/larval crystal cell; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). FBgn0053965 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0053966 Alliance Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Orthologous to human TTPAL (alpha tocopherol transfer protein like). FBgn0031726 Alliance Predicted to enable heme binding activity and iron ion binding activity. Is expressed in amnioserosa; embryonic Malpighian tubule; and yolk nucleus. FBgn0004828 FlyBase Gene Snapshot Histone H3.3B (His3.3B) encodes one of two single copy histone H3 variants. His3.3A and His3.3B transcription is not under control of the cell cycle. His3.3B has a long 3'-UTR (> 1500 nucleotides) and can be processed at different polyadenylation sites which are tissue-specific. FBgn0053517 FlyBase Gene Snapshot "Dopamine 2-like receptor (Dop2R) encodes a G protein-coupled receptor that is activated by dopamine. Postulated Dop2R-mediated functions include regulation of: aggression, cardiac function, feeding, levels of juvenile hormone and 20-hydroxyecdysone, lifespan, locomotor activity, nocturnal activity, olfactory associative learning, response to stress, sleep and sucrose acceptance." FBgn0035021 UniProtKB "Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. May be involved in pre-mRNA splicing. (UniProtKB:Q2PE14)" FBgn0000094 FlyBase Gene Snapshot Andropin (Anp) encodes an antibacterial peptide expressed in the male genital tract. FBgn0035083 UniProtKB Putative gamma-glutamylcyclotransferase. (UniProtKB:Q9W0Y1) FBgn0037137 FlyBase Gene Snapshot "Nopp140 (Nopp140) encodes a nucleolar and Cajal body protein. It is predicted to function as a chaperone in the assembly of small nucleolar ribonucleoprotein particles within Cajal bodies, their transit to nucleoli, and their association with pre-ribosomal RNA within nucleolar dense fibrillar regions." FBgn0010241 Alliance "Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in renal tubular secretion and response to insecticide. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5)." FBgn0002283 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in fat body; organism; and ovary. Orthologous to human PCGF3 (polycomb group ring finger 3). FBgn0000355 UniProtKB Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment. (UniProtKB:P07185) FBgn0039020 UniProtKB Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity). (UniProtKB:Q9VCU5) FBgn0038405 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be active in chitin-based extracellular matrix. Is expressed in dorsal head epidermis. FBgn0030863 UniProtKB "Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (UniProtKB:Q9VX25)" FBgn0003687 FlyBase Gene Snapshot "TATA binding protein (Tbp) encodes a basal transcription factor required at most RNA Pol I and Pol II-transcribed genes. Traditionally thought to be recruited only to TATA box containing promoters, recent work shows that promoters with very weak TATA box consensus sequences also recruit the product of Tbp as a part of the multisubunit TFIID basal transcription factor or via the SAGA histone acetyltransferase complex." FBgn0051007 Alliance "Predicted to be involved in mitochondrion organization. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10)." FBgn0032157 FlyBase Gene Snapshot "Etl1 (Etl1) encodes a protein belonging to the Etl1 subfamily of the Snf2 family of helicase-related proteins. It mediates nucleosomal H2A acetylation in an ATP-dependent fashion via the product of nej, resulting in transcriptional regulation." FBgn0043841 FlyBase Gene Snapshot virus-induced RNA 1 (vir-1) is produced from a promoter that is induced by viral infection. It can be used as a marker of the induction of an antiviral response. Its expression is regulated by the Jak/STAT pathway. FBgn0010265 FlyBase Gene Snapshot Ribosomal protein S13 (RpS13) encodes a structural constituent of ribosomes. FBgn0022893 FlyBase Gene Snapshot Decondensation factor 31 (Df31) encodes a histone binding protein involved in nucleosome assembly. FBgn0037385 Alliance Predicted to enable heme binding activity and oxygen binding activity. Predicted to be located in cytoplasm. Is expressed in early elongation stage spermatid; onion stage spermatid; organism; primary spermatocyte; and secondary spermatocyte. FBgn0052857 UniProtKB Molecular scaffold for (UniProtKB:Q8SY96) FBgn0032391 FlyBase Gene Snapshot "escl (escl) encodes an essential component of the Polycomb Repressive Complex 2, whose function is to methylate histone H3K27. Although the product of escl is functionally equivalent to the product of esc, it is not maternally supplied in equally high levels and some homeotic phenotypes occur in the absence of the product of esc." FBgn0045759 FlyBase Gene Snapshot biniou (bin) encodes a forkhead domain transcription factor that forms visceral mesoderm that differentiates into gut musculature. FBgn0036374 Alliance "Predicted to enable transcription coregulator activity. Predicted to be involved in chromatin organization and regulation of transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in chordotonal neurons. Orthologous to several human genes including SUPT20H (SPT20 homolog, SAGA complex component)." FBgn0034566 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in sensory perception of sound. Predicted to be part of outer dynein arm. Is expressed in Johnston organ neurons; chordotonal neurons; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1). FBgn0031285 Alliance Predicted to enable amyloid-beta binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to several human genes including ITM2C (integral membrane protein 2C). FBgn0004050 FlyBase Gene Snapshot "zeste (z) encodes a sequence-specific DNA-binding protein. It is often found in the proximal promoter region of many genes where it helps to recruit the BRM nucleosome remodeling complex. It is best known for the pairing-dependent repressive effects produced by some of its mutants on target genes, especially the w gene." FBgn0004644 FlyBase Gene Snapshot "hedgehog (hh) encodes the Hh signaling pathway ligand. It acts as a morphogen contributing to segment polarity determination, stem cells maintenance and cell migration. Post-translational modifications of the product of hh are essential for its restrictive spreading and signaling activity." FBgn0031765 Alliance Predicted to enable acetylglucosaminyltransferase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Peters plus syndrome. Orthologous to human B3GLCT (beta 3-glucosyltransferase). FBgn0030522 UniProtKB Positive regulator of Notch signaling (PubMed:34905536). Maternal neurogenic factor involved in Notch signaling-dependent neuroectodermal specification during early embryogenesis (PubMed:34905536). Functions cooperatively with amx/TM2D3 and bisc/TM2D1 (PubMed:34905536). (UniProtKB:Q9VY86) FBgn0028540 Alliance "Predicted to enable glucose-6-phosphate 1-epimerase activity. Involved in defense response to virus. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; dorsal head epidermis; dorsal pharyngeal muscle cell; embryonic head epidermis; and gut section." FBgn0000459 FlyBase Gene Snapshot disconnected (disco) encodes a C2H2 zinc finger transcription factor involved in development of ventral appendages (e.g. legs and some mouthparts) during embryogenesis and metamorphosis. FBgn0038980 UniProtKB "Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15816867, PubMed:22553037). Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037). Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037). (UniProtKB:Q9VCZ3)" FBgn0000529 FlyBase Gene Snapshot brain-specific homeobox (bsh) encodes a putative transcription factor required for the specification of neural type identities in the adult brain. FBgn0010607 Alliance "Is expressed in several structures, including central brain primordium; embryonic/larval esophageal visceral muscle; ganglia; mesoderm; and ventral nerve cord primordium." FBgn0003943 FlyBase Gene Snapshot "Ubiquitin-63E (Ubi-p63E) encodes a polyubiquitin precursor: once processed by deubiquitinating enzymes, it produces ten ubiquitin molecules, which are predominantly conjugated to target proteins. Ubiquitin conjugation is involved in a wide range of biological processes, such as protein degradation, endocytosis of plasma membrane proteins, protein trafficking, DNA-damage response and inflammation and immune system response." FBgn0050072 Alliance Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0052072 FlyBase Gene Snapshot "Elongase 68alpha (Elo68alpha) encodes a transmembrane fatty acid elongase, elongating Delta9 unsaturated LCFAs (C14 and C16) to Delta11 LCFAs (C16 and C18), that is involved in the synthesis of the male pheromone cis-vaccenyl acetate." FBgn0052056 FlyBase Gene Snapshot "scramblase 1 (scramb1) encodes a protein that, together with the product of scramb2, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis." FBgn0015773 UniProtKB Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles. (UniProtKB:Q24567) FBgn0003002 FlyBase Gene Snapshot "odd paired (opa) encodes a transcription factor that acts as a pair rule gene during early embryogenesis, as well as being involved in midgut morphogenesis. After embryogenesis, it contributes to adult head morphogenesis, neural stem cell development, and circadian rhythm." FBgn0039369 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0037326 Alliance Predicted to enable GTP binding activity and GTPase activity. Is expressed in adult head. Orthologous to several human genes including RASL10A (RAS like family 10 member A). FBgn0004087 FlyBase Gene Snapshot "Dihydrofolate reductase (Dhfr) encodes an NADPH-dependent enzyme used to convert folic acid and dihydrofolate to tetrahydrofolate, which is used as a cofactor for the biosynthesis of purines, thymidylate, and several amino acids. Dhfr product contributes to cell proliferation and cell growth." FBgn0033631 FlyBase Gene Snapshot Superoxide dismutase 3 (Sod3) encodes an extra-cellular Cu Zn superoxide dismutase that can be produced as secreted and membrane bound forms. It converts oxygen free radicals to hydrogen peroxide and is involved in free radical defense and redox balance. FBgn0000370 FlyBase Gene Snapshot cryptocephal (crc) encodes a protein that belongs to a member of the CREB/ATF family of basic-leucine zipper transcription factors. It serves as an coactivator of the product EcR of to promote expression the molting peptide hormone encoded by ETH. It also acts as an unfolded protein response transcription factor to regulate glycolytic genes in response to ER stress. FBgn0026433 FlyBase Gene Snapshot "Grip128 (Grip128) encodes a component of the Gamma-tubulin ring complex, which is a potent microtubule nucleator in eukaryotic cells essential for successful chromosome segregation and cell division." FBgn0053969 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4). FBgn0039366 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in organism. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0004363 FlyBase Gene Snapshot "porin (porin) encodes a beta-barrel channel protein localized in the outer membrane of mitochondria that conducts translocation of various ions and metabolites between cytoplasm and mitochondria. It plays roles in mitochondria dynamics and mitophagy, and is ubiquitinated by the E3 ligases encoded by park and Mul1." FBgn0036680 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head; embryonic salivary gland duct; and embryonic ventral epidermis. FBgn0039370 Alliance Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in organism. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). FBgn0013263 FlyBase Gene Snapshot "Trithorax-like (Trl) encodes a GAGA transcription factor involved in chromatin modification. It contributes to cell division, dosage compensation and gametogenesis." FBgn0036306 Alliance Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be active in endoplasmic reticulum. Is expressed in organism. Orthologous to human HSPBP1 (HSPA (Hsp70) binding protein 1). FBgn0260479 Alliance Predicted to enable glycine:sodium symporter activity and neurotransmitter transmembrane transporter activity. Predicted to be involved in amino acid import across plasma membrane; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to several human genes including SLC6A11 (solute carrier family 6 member 11); SLC6A12 (solute carrier family 6 member 12); and SLC6A13 (solute carrier family 6 member 13). FBgn0038547 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain and larval ventral nerve cord." FBgn0024941 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be active in cytoplasm and neuron projection. Is expressed in adult head. Orthologous to human RGS6 (regulator of G protein signaling 6) and RGS7 (regulator of G protein signaling 7). FBgn0053970 Alliance "Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Located in apical plasma membrane. Is expressed in several structures, including adult fat body; adult head; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. Used to study autosomal recessive congenital ichthyosis." FBgn0014396 FlyBase Gene Snapshot "timeless (tim) encodes a key component of the tim-per complex, required for the production of circadian rhythms. It is involved in mating behavior, DNA replication and larval phototaxis." FBgn0013765 FlyBase Gene Snapshot "centrosomin (cnn) encodes an essential mitotic centrosome component. During early embryogenesis it is required to organize the mitotic spindle, the actin cytoskeleton and centriole replication. It is also required for mitotic and meiotic divisions during spermatogenesis, as well as organization of the sperm axoneme. The product of cnn can interact with microtubules, actin and the kinase encoded by polo." FBgn0016977 UniProtKB "Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins. (UniProtKB:Q8SX83)" FBgn0016930 UniProtKB In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation. (UniProtKB:Q9V3D5) FBgn0031971 FlyBase Gene Snapshot "Starvation-upregulated protein (Sirup) encodes a critical assembly factor for Complex II in the electron transport chain of mitochondria. Loss of Sirup results in motility defects, neurodegeneration, and oxidative stress." FBgn0031619 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in ventral sensory complex primordium. FBgn0010488 FlyBase Gene Snapshot NAT1 (NAT1) encodes a protein involved in chaeta development. FBgn0033781 Alliance Predicted to be involved in proteasome assembly. Is expressed in adult head. Orthologous to human PSMG4 (proteasome assembly chaperone 4). FBgn0011205 FlyBase Gene Snapshot "fumble (fbl) encodes an enzyme that phosphorylates pantothenate (vitamin B5), which is one of the early steps of the Coenzyme A de novo biosynthesis pathway." FBgn0053971 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in labellum; leg taste bristle chemosensory neurons; and tarsal segment 5. FBgn0020381 FlyBase Gene Snapshot "Death related ced-3/Nedd2-like caspase (Dredd) encodes a protein that functions downstream of Fadd, and is thought to activate by cleavage the transcription factor encoded by Rel in the immune deficiency pathway. This pathway regulates the antibacterial response and other less characterized cellular processes." FBgn0035209 FlyBase Gene Snapshot "mitotic spindle density 1 (msd1) encodes a subunit of the hetero-octameric Augmin complex. The complex binds and localises to microtubules, where it recruits gamma tubulin, facilitating new microtubule nucleation. It has a crucial role in ensuring enough microtubules are generated within the mitotic spindle to facilitate chromosome segregation." FBgn0037525 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of centriole replication. Is expressed in adult head. FBgn0031623 Alliance Enables protein heterodimerization activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Located in male germ cell nucleus. FBgn0004911 Alliance Is expressed in embryonic/larval salivary gland. FBgn0053309 Alliance Is expressed in primary spermatocyte; secondary spermatocyte; and spermatid. FBgn0011937 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0011936 Alliance Predicted to enable AAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0000406 UniProtKB May play a role in muscle cell metabolism. (UniProtKB:P19967) FBgn0004052 FlyBase Gene Snapshot "Z600 (Z600) encodes a mitotic inhibitor that binds to the hydrophobic patch of Cyclins. It contributes to the switch in cell cycle mode in blastoderm embryos, and delaying mitosis in the mesoderm anlage to avoid an interference of mitosis and morphogenesis." FBgn0039544 Alliance Predicted to enable exonuclease activity. Predicted to be active in nucleus. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). FBgn0014869 FlyBase Gene Snapshot Phosphoglycerate mutase 1 (Pgam1) encodes an enzyme that catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate. It is involved in glycolysis while the reverse reaction is involved in gluconeogenesis. FBgn0013720 FlyBase Gene Snapshot pickel (pck) encodes a transmembrane protein of the Claudin superfamily. It is part of the septate junction (SJ) core complex and essential for SJ morphogenesis and function. The transepithelial barrier function of epithelial tissues is affected in pck mutants. FBgn0003638 UniProtKB "Regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). Regulates its own expression at the level of RNA processing. (UniProtKB:P12297)" FBgn0000276 FlyBase Gene Snapshot "Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway." FBgn0041624 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:P82983)" FBgn0041623 UniProtKB "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (UniProtKB:P82984)" FBgn0010438 UniProtKB "Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:7673145, PubMed:8206370). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase PolG1/tam at the replication fork (PubMed:11294889, PubMed:14754882, PubMed:21953457, PubMed:26446790, PubMed:28318978, PubMed:7673145). Promotes PolG1 activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate PolG1 activity (PubMed:21953457, PubMed:26446790, PubMed:7673145). (UniProtKB:P54622)" FBgn0021764 FlyBase Gene Snapshot "sidekick (sdk) encodes a member of the immunoglobulin superfamily and is involved in epithelial remodeling and synapse formation. In epithelia, sdk localizes preferentially to tricellular adherens junctions, where three or more cells meet. It promotes actin branching and lengthening of cell-cell contact through interaction with the WAVE regulatory complex. Alternatively, it promotes contraction of cell-cell contacts through interaction with pyd, which in turn interacts with contractile actomyosin." FBgn0040099 Alliance Predicted to enable galactose binding activity. Predicted to be involved in opsonization. Predicted to be located in extracellular space. Is expressed in adult heart and eye. Human ortholog(s) of this gene implicated in 3MC syndrome 3; asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to several human genes including COLEC10 (collectin subfamily member 10); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). FBgn0004618 FlyBase Gene Snapshot "glass (gl) encodes a zinc finger transcription factor involved in cell fate specification. It is primarily transcribed in photoreceptors, where its expression is activated by the retinal determination member encoded by so. gl is required for correctly patterning the retina, rhabdomere formation, and for the expression of phototransduction proteins" FBgn0029854 Alliance Predicted to enable heme binding activity. Predicted to be involved in sterol biosynthetic process. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. FBgn0000278 FlyBase Gene Snapshot Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage. FBgn0038002 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0051274 Alliance Is expressed in organism. FBgn0038427 FlyBase Gene Snapshot endosomal maturation defective (ema) encodes a protein involved in membrane trafficking that is required for endosomal maturation and autophagy. FBgn0035976 FlyBase Gene Snapshot "Peptidoglycan recognition protein LC (PGRP-LC) encodes a transmembrane receptor involved in the recognition of DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It functions upstream of the immune deficiency pathway." FBgn0027514 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism." FBgn0038063 UniProtKB "Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037). (UniProtKB:Q4LBB9)" FBgn0053977 Alliance "Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type I and muscular dystrophy-dystroglycanopathy type B15. Orthologous to human DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory)." FBgn0053978 Alliance Predicted to enable calcium ion binding activity. Is expressed in spermatozoon. FBgn0000551 FlyBase Gene Snapshot Ecdysone-dependent gene 78E (Edg78E) encodes a pupal cuticle protein that is induced by ecdysone during prepupal development. It is only found in the pupal exocuticle where it binds chitin and serves as part of the structural basis of the cuticle. FBgn0032130 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; cuboidal/columnar epithelium; gut section; head epidermis primordium; and mesoderm." FBgn0035879 Alliance Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be located in cytosol. Orthologous to several human genes including RABGAP1 (RAB GTPase activating protein 1). FBgn0035880 FlyBase Gene Snapshot CUB and LDLa domain (Culd) encodes a photoreceptor-cell enriched transmembrane protein. It localizes to endocytic vesicles and is required for endocytic trafficking of the products of ninaE and trpl. FBgn0038717 Alliance Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). FBgn0001091 FlyBase Gene Snapshot Glyceraldehyde-3-phosphate dehydrogenase 1 (Gapdh1) encodes an enzyme that catalyzes that D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate and is involved in glycolysis. The reverse reaction is involved in gluconeogenesis. FBgn0031261 Alliance "Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in cholinergic synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including adult head; embryonic foregut sensory structure; embryonic head sensory system; embryonic optic lobe primordium; and sensory nervous system primordium." FBgn0031859 Alliance Is expressed in spermatozoon. FBgn0001125 FlyBase Gene Snapshot "Glutamate oxaloacetate transaminase 2 (Got2) encodes a mitochondrial enzyme that catalyzes the interconversion of L-aspartate and alpha-ketoglutarate to oxaloacetate and L-glutamate. It is involved in glutamate and aspartate biosynthesis, gluconeogenesis and the malate-aspartate shuttle." FBgn0024983 Alliance "Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human ERGIC2 (ERGIC and golgi 2)." FBgn0000640 FlyBase Gene Snapshot "Fat body protein 2 (Fbp2) encodes a 256 amino acid protein that accumulates in the larval fat-body at the third larval and pupal stages. The product of Fbp2 is related to the alcohol dehydrogenase encoded by Adh but has no known enzymatic function. The Fbp2-encoded polypeptide contains 20% methionine, whereas there are no methionines in mature polypeptide encoded by Adh, therefore it is thought to be a sulfur-storage protein at metamorphosis." FBgn0037764 Alliance Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult fat body and adult head. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). FBgn0050087 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0053460 Alliance Predicted to be involved in proteolysis. FBgn0053461 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0053462 Alliance Predicted to enable serine-type endopeptidase activity. Involved in sexual reproduction. Predicted to be located in extracellular region. FBgn0025741 FlyBase Gene Snapshot "Plexin A (PlexA) encodes a transmembrane receptor for Semaphorin ligands encoded by Sema1a and Sema1b. The intracellular region of this receptor has GTPase activating protein (GAP) activity on Ras/Rap small GTPases. The signaling by the product of PlexA alters actin, microtubules and cell adhesion in developmental processes such as axon guidance." FBgn0000044 FlyBase Gene Snapshot "Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle." FBgn0031504 Alliance Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human FAM210B (family with sequence similarity 210 member B). FBgn0034495 Alliance "Predicted to be involved in maintenance of mitotic sister chromatid cohesion and regulation of DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of Ctf18 RFC-like complex and chromatin. Predicted to be active in chromosome, centromeric region. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1)." FBgn0039925 Alliance Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex and cell projection organization. Predicted to be part of kinesin complex. Predicted to be active in cilium; microtubule cytoskeleton; and neuron projection. Orthologous to human KIF17 (kinesin family member 17). FBgn0033104 Alliance Predicted to be involved in regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC15 (anaphase promoting complex subunit 15). FBgn0026086 FlyBase Gene Snapshot "Adenosine deaminase acting on RNA (Adar) encodes an RNA editing enzyme. It is involved in behaviour, glucose metabolism and response to several stresses such as heat, hypoxia and oxidative stress." FBgn0036203 Alliance Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval gut; embryonic/larval salivary gland; and organism. FBgn0028741 FlyBase Gene Snapshot "fab1 kinase (fab1) encodes a phosphatidylinositol-3-phosphate 5-kinase. It phosphorylates phosphatidylinositol-3-phosphate lipid head groups on the cytosolic leaflet of endosomal compartments. The product of fab1 functions in late endosome-to lysosome trafficking, retrograde trafficking, and autophagy." FBgn0010339 UniProtKB Deformed (Dfd) is required to activate 128up in maxillary segment cells. (UniProtKB:P32234) FBgn0053983 Alliance Predicted to enable chitin binding activity. Predicted to be located in chitin-based extracellular matrix. Is expressed in embryonic/larval garland cell. FBgn0053985 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0053986 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0003300 FlyBase Gene Snapshot "runt (run) encodes an alpha-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It contributes to axon guidance, dendrite morphogenesis and germ-band extension." FBgn0037635 Alliance Is expressed in embryonic/larval midgut; embryonic/larval midgut primordium; and visceral mesoderm derivative. FBgn0040508 Alliance Predicted to enable adenylate cyclase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in organism; spermatid; and spermatocyte. Orthologous to human ADCY7 (adenylate cyclase 7). FBgn0053987 Alliance "Is expressed in several structures, including Malpighian tubule primordium; clypeo-labral primordium; embryonic Malpighian tubule; embryonic hindgut; and hindgut proper primordium." FBgn0028979 FlyBase Gene Snapshot "tiptop (tio) encodes a DNA binding protein involved in the formation of embryonic thoracic segments, Malpighian tubules, and eye development." FBgn0053988 Alliance Contributes to leak channel activity. Involved in locomotor rhythm and social behavior. Part of cation channel complex. Is expressed in dorsal ectoderm; ganglia; sensory cluster; ventral ectoderm; and ventral nerve cord primordium. Orthologous to human NALF1 (NALCN channel auxiliary factor 1) and NALF2 (NALCN channel auxiliary factor 2). FBgn0052176 Alliance "Predicted to be involved in regulation of apoptotic process. Is expressed in several structures, including anterior endoderm; central brain primordium; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1)." FBgn0053082 Alliance Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). FBgn0032023 FlyBase Gene Snapshot without maturity (witty) encodes a predicted extracellular GPI-anchored protein of the Ly6 family that is directly up-regulated by retrograde BMP signaling in motor neurons. witty regulates the post-synaptic accumulation of the GluRIIA subunit at the neuromuscular junction. FBgn0052088 FlyBase Gene Snapshot sisters unbound (sunn) encodes a chromosome protein involved in the meiotic sister chromatid cohesion pathway. It is required for sister centromere cohesion in both male and female meiosis and for maintenance of synaptonemal complexes and normal levels of homolog crossing-over in female meiosis. FBgn0026575 FlyBase Gene Snapshot "hangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat." FBgn0067905 FlyBase Gene Snapshot "Daisho2 (Dso2) encodes an immune effector peptide regulated by Toll NF-kappaB signalling. Mutant flies are susceptible to fungal infection, and Dso2 shows binding to fungal hyphae ex vivo." FBgn0036793 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0025637 FlyBase Gene Snapshot "SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication." FBgn0000552 FlyBase Gene Snapshot "Ecdysone-dependent gene 84A (Edg84A) encodes a pupal cuticle protein, assumed to be component of the exocuticle. Edg84A is expressed only in anterior epidermis during the late prepupal period, induced by the transcription factor encoded by ftz-f1." FBgn0032151 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor alpha6 (nAChRalpha6) encodes a postsynaptic receptor involved in cation transport, synaptic transmission, muscle homeostasis and sensitivity to insecticides." FBgn0043791 Alliance "Predicted to enable alkaline phosphatase activity. Involved in response to hypoxia and response to nicotine. Predicted to be located in cell surface. Is expressed in several structures, including amnioserosa; embryonic/larval midgut primordium; endoderm anlage; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0000055 FlyBase Gene Snapshot Alcohol dehydrogenase (Adh) encodes an alcohol and acetaldehyde dehydrogenase involved in alcohol and acetaldehyde metabolism. FBgn0034978 Alliance Is expressed in embryonic antennal sense organ; embryonic brain; embryonic foregut sensory structure; embryonic head sensory system; and larval ventral nerve cord. FBgn0039229 Alliance "Predicted to enable mRNA binding activity and sequence-specific DNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear matrix and nucleoplasm. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval brain; embryonic/larval central nervous system; germline cell; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including SAFB (scaffold attachment factor B)." FBgn0032259 Alliance Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ALKBH6 (alkB homolog 6). FBgn0032815 Alliance "Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle cell; germline cell; and visceral mesoderm derivative. Orthologous to human ZNF236 (zinc finger protein 236)." FBgn0052625 Alliance "Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human GTSF1 (gametocyte specific factor 1)." FBgn0010240 UniProtKB "GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. (UniProtKB:Q08832)" FBgn0051693 Alliance Predicted to enable monoatomic ion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein). FBgn0029526 Alliance "Is expressed in several structures, including embryonic/larval somatic muscle cell; head mesoderm anlage; mesoderm; somatic muscle primordium; and trunk mesoderm anlage." FBgn0003366 UniProtKB Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell. (UniProtKB:P13368) FBgn0041789 FlyBase Gene Snapshot "Paxillin (Pax) encodes an adaptor protein that is generally associated with integrins. It is not required for most integrin-mediated adhesion or migration events, but is required for viability beyond pupal stages. It controls the size of some muscles by regulating the rate of cell fusion." FBgn0013718 FlyBase Gene Snapshot "nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes." FBgn0030984 Alliance "Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Is expressed in several structures, including embryonic/larval nervous system; gastric caecum; gut section; nurse cell; and testis. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1)." FBgn0039736 Alliance Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC26A11 (solute carrier family 26 member 11). FBgn0022359 Alliance Enables L-iditol 2-dehydrogenase (NAD+) activity. Involved in fructose biosynthetic process and sorbitol catabolic process. Is expressed in adult head; amnioserosa; embryonic/larval midgut; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). FBgn0024250 FlyBase Gene Snapshot "brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling." FBgn0020906 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in embryonic/larval digestive system. FBgn0030336 Alliance Predicted to enable diphthine-ammonia ligase activity. Predicted to be involved in protein histidyl modification to diphthamide. Orthologous to human DPH6 (diphthamine biosynthesis 6). FBgn0031762 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Ras protein signal transduction and positive regulation of peptidyl-serine phosphorylation. Is expressed in embryonic brain; embryonic/larval nervous system; and larval ventral nerve cord. Orthologous to several human genes including BCAR3 (BCAR3 adaptor protein, NSP family member) and SH2D3C (SH2 domain containing 3C)." FBgn0000719 FlyBase Gene Snapshot "folded gastrulation (fog) encodes a secreted ligand that signals via GPCRs to co-ordinate cell shape change during gastrulation; in the nervous system, it regulates motor axon guidance, glial organization and morphogenesis." FBgn0032626 Alliance Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in regulation of signal transduction. Orthologous to several human genes including PPP1R2B (PPP1R2 family member B); PPP1R2C (PPP1R2C family member C); and PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). FBgn0030581 Alliance Predicted to enable protein kinase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in embryonic brain; embryonic/larval midgut; embryonic/larval nervous system; larval ventral nerve cord; and organism. FBgn0030874 FlyBase Gene Snapshot Spt7 (Spt7) encodes a subunit of the SAGA chromatin modifying complex. FBgn0030262 FlyBase Gene Snapshot "Vago (Vago) encodes a single von Willebrand type C factor domain protein, induced by viral infection. Its induction depends on the product of Dcr-2, and it functions to restrict Drosophila C virus replication in the fat body of adult flies." FBgn0004643 FlyBase Gene Snapshot "Zeste-white 10 (Zw10) encodes a subunit of the RZZ complex located at the kinetochores of chromosomes. The RZZ complex plays an essential role in the spindle assembly checkpoint that ensures proper connections between chromosomes and the mitotic spindle. The product of Zw10 is also found on the Golgi stacks and endoplasmic reticulum, where it functions in membrane formation and trafficking." FBgn0034997 FlyBase Gene Snapshot "Acid sphingomyelinase (Asm) encodes a lysosomal-secreted acid sphingomyelinase which converts exosomal membrane vesicles to a lipid film in Drosophila airways, just before birth. The film is necessary for gas filling of the airways and animal survival." FBgn0000320 FlyBase Gene Snapshot "eyes absent (eya) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by ey, dac, and so. The product of eya regulates eye, gonad, and brain development as well as axon pathfinding." FBgn0029836 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section." FBgn0036599 Alliance Is expressed in adult head. FBgn0045842 FlyBase Gene Snapshot "yuri gagarin (yuri) encodes a protein involved in gravitaxis, ciliary basal body organization and sperm individualization." FBgn0027101 Alliance Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in eye disc morphogenetic furrow; organism; and third segment of antenna. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). FBgn0039924 FlyBase Gene Snapshot "Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) encodes an enzyme that mediates the conversion of phosphatidylinositol 4 phosphate to phosphatidylinositol 4,5 bisphosphate. It has been implicated in the regulation of mTOR signalling and control of cell size." FBgn0053993 UniProtKB "Involved in the negative regulation of the Egfr/Ras signaling pathway (PubMed:34411095). During wing morphogenesis, may function redundantly with PVRAP to inhibit Egfr activity and prevent uncontrolled cell growth (PubMed:34411095). (UniProtKB:Q6NR09)" FBgn0040344 UniProtKB "Inhibitor of Ras signaling (PubMed:30442766). Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (By similarity). Together with Nf1, plays an important role for normal sleep behavior, mainly during the night (PubMed:32339168). Might affect sleep by modulating GABA signaling in Rdl-expressing neurons (PubMed:32339168). Might play a role in the regulation of brain glycogen metabolism and organismal levels of triglycerides (PubMed:32339168). (UniProtKB:Q9V410)" FBgn0034121 Alliance "Predicted to enable alpha,alpha-trehalase activity. Predicted to be involved in trehalose catabolic process. Is expressed in adult head and spermatozoon. Orthologous to human TREH (trehalase)." FBgn0004463 FlyBase Gene Snapshot RNA polymerase III subunit B (Polr3B) encodes one of the subunits that forms the multi-protein RNA Polymerase III holoenzyme. RNA Polymerase III transcribes several types of small non-coding RNAs in the nuclear genome including tRNAs and 5SrRNA. FBgn0031515 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in olfactory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0053301 Alliance Predicted to enable ecdysteroid 22-kinase activity. Is expressed in adult head. FBgn0014903 Alliance Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). FBgn0037046 Alliance "Predicted to enable ribonucleoside triphosphate phosphatase activity. Is expressed in adult head. Orthologous to human NTPCR (nucleoside-triphosphatase, cancer-related)." FBgn0053995 Alliance Predicted to be involved in negative regulation of biosynthetic process. FBgn0034286 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in dorsal sensory complex proper primordium; embryonic brain; larval ventral nerve cord; and ventral sensory complex primordium. FBgn0032955 Alliance Predicted to enable choline kinase activity and ethanolamine kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to several human genes including CHKB (choline kinase beta). FBgn0050098 Alliance Predicted to enable serine-type endopeptidase activity. Involved in defense response to Gram-positive bacterium. FBgn0032405 Alliance "Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in lipid droplet. Is expressed in adult head. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13); and RDH10 (retinol dehydrogenase 10)." FBgn0029608 Alliance Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). FBgn0031637 FlyBase Gene Snapshot mextli (mxt) encodes a protein that promotes translation. It binds to the products of eIF4E1 and eIF3h. It contributes to maintenance of germline stem cells and it is also involved in early embryogenesis. FBgn0034139 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in spermatozoon. FBgn0030897 UniProtKB "Ca(2+)-dependent modulation of synaptic efficacy (PubMed:17970740, PubMed:8101711). Also plays a role in axon terminal morphology (PubMed:17970740). (UniProtKB:P37236)" FBgn0015664 FlyBase Gene Snapshot "DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance." FBgn0039592 Alliance Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). FBgn0053544 FlyBase Gene Snapshot "Vitamin-K epoxide reductase (Vkor) encodes an enzyme that converts Vitamin-K 2,3-epoxide back to the active form of Vitamin-K by de-epoxidation." FBgn0053998 Alliance Is expressed in adult fat body. FBgn0054001 Alliance Predicted to be involved in mitotic sister chromatid cohesion. Predicted to be part of Ctf18 RFC-like complex. Orthologous to human CHTF8 (chromosome transmission fidelity factor 8). FBgn0054002 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Orthologous to human GLIPR1 (GLI pathogenesis related 1) and CRISP1 (cysteine rich secretory protein 1). FBgn0054003 Alliance Predicted to be located in extracellular region. FBgn0040658 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in apoptotic process. Predicted to be located in Golgi apparatus and nucleoplasm. FBgn0054010 FlyBase Gene Snapshot Glycine N-acyltransferase (Glyat) encodes a modulator of cell death mediated by the JNK signalling pathway. FBgn0054015 Alliance Predicted to enable adenosine 5'-monophosphoramidase activity. Is expressed in adult head. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3). FBgn0054025 Alliance Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. FBgn0054026 Alliance Is expressed in adult head and adult heart. FBgn0054031 Alliance "Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of DNA-templated transcription." FBgn0054033 FlyBase Gene Snapshot CG34033 encodes a protein with homology to C-type lectins produced in the male accessory gland and transferred to females during mating. FBgn0054034 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0038156 Alliance Is expressed in adult head; hypodermal muscle cell of A1-7; and somatic muscle primordium. FBgn0053635 Alliance "Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in Golgi membrane. Orthologous to human SFT2D3 (SFT2 domain containing 3)." FBgn0053465 Alliance Predicted to be involved in proteolysis. Is expressed in embryonic anal pad. FBgn0054039 Alliance Orthologous to human COMMD4 (COMM domain containing 4). FBgn0054041 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0065110 Alliance "Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult spiracle; external compound sense organ; olfactory receptor neuron of dorsal organ; primary tracheal branch; and tracheal tip cell." FBgn0054049 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). FBgn0054051 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0065108 Interactive Fly DEG/ENaC sodium channel subunits - homeostatic modulation of presynaptic neurotransmitter release FBgn0065109 FlyBase Gene Snapshot "pickpocket 11 (ppk11) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. It functions in salt taste in adult flies." FBgn0054056 Alliance "Enables beta-1,3-galactosyltransferase activity. Involved in protein glycosylation. Predicted to be located in membrane. Is expressed in embryonic/larval brain; follicle cell; gland; imaginal disc; and tracheal primordium." FBgn0054057 Alliance Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Tn polyagglutination syndrome and hemolytic-uremic syndrome. Orthologous to human C1GALT1C1 (C1GALT1 specific chaperone 1) and C1GALT1C1L (C1GALT1 specific chaperone 1 like). FBgn0260453 Alliance Enables monoatomic ion channel activity and porin activity. Involved in monoatomic ion transport. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head; spermatozoon; and testis. FBgn0260454 Alliance Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in monoatomic anion transmembrane transport. Predicted to be active in mitochondrial outer membrane. FBgn0052529 Interactive Fly chromatin component - a molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production FBgn0013696 Alliance Predicted to enable AUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013703 Alliance Predicted to enable CAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013700 Alliance Predicted to enable AUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013680 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProtKB:P03896) FBgn0013709 Alliance Predicted to enable UGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013690 Alliance Predicted to enable UGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013710 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013674 FlyBase Gene Snapshot "mitochondrial Cytochrome c oxidase subunit I (mt:CoI) is a mitochondrial gene encoding one of the catalytic subunits of the mitochondrial electron transport chain complex IV, which reduces molecular oxygen to water." FBgn0013699 Alliance Predicted to enable UUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013675 UniProtKB "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProtKB:P00408)" FBgn0013697 Alliance Predicted to enable AAG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013691 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013673 FlyBase Gene Snapshot mitochondrial ATPase subunit 8 (mt:ATPase8) is a mitochondrial DNA gene that encodes a subunit of the mitochondrial ATP synthase localized to the inner mitochondrial membrane. FBgn0013672 FlyBase Gene Snapshot mitochondrial ATPase subunit 6 (mt:ATPase6) encodes a mitochondrial inner transmembrane protein that is key for oxidative phosphorylation. It couples hydrogen ion transport to ATP synthesis functioning as part of the ATP synthase. FBgn0013676 UniProtKB "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProtKB:P00417)" FBgn0013694 Alliance Predicted to enable GGA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013681 FlyBase Gene Snapshot mitochondrial NADH-ubiquinone oxidoreductase chain 3 (mt:ND3) a mitochondrial DNA gene that encodes a subunit of complex I of the mitochondrial respiratory chain localized in the inner membrane of mitochondria. FBgn0013689 Alliance Predicted to enable GCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013704 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013701 Alliance Predicted to enable GAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013705 Alliance Predicted to enable AGC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013692 Alliance Predicted to enable GAA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013693 Alliance Predicted to enable UUC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013684 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProtKB:P18932) FBgn0013695 Alliance Predicted to enable CAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013683 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProtKB:P18934) FBgn0013707 Alliance Predicted to enable triplet codon-amino acid adaptor activity. FBgn0013702 Alliance Predicted to enable UAC codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013685 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProtKB:P18933) FBgn0013678 UniProtKB Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (UniProtKB:P18935) FBgn0013706 Alliance Predicted to enable UCA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013679 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProtKB:P18929) FBgn0013698 Alliance Predicted to enable CUA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in mitochondrion. FBgn0013686 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in pole cell formation. Predicted to be located in P granule. FBgn0013708 Alliance Predicted to enable triplet codon-amino acid adaptor activity. FBgn0013688 Alliance Predicted to be involved in pole cell formation. Located in P granule. FBgn0041004 Alliance Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human TMEM65 (transmembrane protein 65). FBgn0058191 Alliance Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). FBgn0040011 Alliance Involved in negative regulation of hippo signaling and negative regulation of peptidoglycan recognition protein signaling pathway. Part of FAR/SIN/STRIPAK complex. Is expressed in adult head and organism. Orthologous to several human genes including SLMAP (sarcolemma associated protein). FBgn0040009 Alliance Is expressed in organism. FBgn0039958 Alliance Predicted to enable 8-oxo-dGDP phosphatase activity. FBgn0040038 FlyBase Gene Snapshot "kelch like family member 10 (klhl10) encodes a protein that functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation." FBgn0058006 Alliance Predicted to enable scavenger receptor activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in embryonic/larval garland cell and embryonic/larval salivary gland. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). FBgn0000384 UniProtKB "May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (UniProtKB:P25157)" FBgn0039966 Alliance "Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in cortical actin cytoskeleton organization and positive regulation of autophagosome maturation. Located in early endosome. Is expressed in several structures, including Bolwig organ; adult ensheathing glial cell; brain; imaginal disc; and synaptic neuropil domain. Orthologous to human RAB21 (RAB21, member RAS oncogene family)." FBgn0025837 Alliance "Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene)." FBgn0025836 FlyBase Gene Snapshot Rho GTPase activating protein at 1A (RhoGAP1A) encodes a protein involved in Golgi organization and cell growth inhibition. FBgn0025835 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups." FBgn0003559 FlyBase Gene Snapshot suppressor of forked (su(f)) is an essential gene that encodes a protein involved in mRNA 3'-end processing (the nuclear cleavage/polyadenylation reaction) and alternative poly(A) site utilization. su(f) product accumulates in dividing cells where it is required for mitosis progression. FBgn0039943 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in miRNA processing. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). FBgn0039942 Alliance Is expressed in organism. FBgn0039941 Alliance "Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and organism." FBgn0040031 Alliance "Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VI. Orthologous to human SLC24A5 (solute carrier family 24 member 5)." FBgn0039965 UniProtKB Required for locomotion. Probably involved in the regulation of formation/maintenance of motor neurons at presynaptic terminals at the neuromuscular junction. (UniProtKB:Q9W5N0) FBgn0063670 UniProtKB Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. (UniProtKB:Q8MQI6) FBgn0028697 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 12. Orthologous to human RPL15 (ribosomal protein L15). FBgn0058002 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Orthologous to human NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2). FBgn0037549 Alliance Predicted to enable RNA helicase activity and mRNA binding activity. Is expressed in adult head; germline cell; gonad; and organism. Orthologous to human DDX43 (DEAD-box helicase 43) and DDX53 (DEAD-box helicase 53). FBgn0040022 FlyBase Gene Snapshot SET domain containing 1 (Set1) encodes an enzyme that methylates histone H3 on lysine 4 at promoter-proximal regions of most RNA Polymerase II transcribed genes. It is the catalytic subunit of the COMPASS complex. FBgn0058160 Alliance Involved in melanization defense response and zymogen activation. Located in extracellular region. FBgn0040056 Alliance Predicted to enable calcium ion binding activity and protein serine/threonine kinase activity. Predicted to be located in cytoplasm. Orthologous to several human genes including CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). FBgn0039955 Alliance Predicted to enable metal ion binding activity. Involved in embryonic morphogenesis; endocytosis; and epithelial cell morphogenesis. Located in vacuole. Is expressed in adult head; head mesoderm; organism; trunk mesoderm; and ventral ectoderm. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). FBgn0058198 Alliance Is expressed in adult fat body. FBgn0083992 FlyBase Gene Snapshot MAP kinase-specific phosphatase (Mkp) encodes a member of mitogen-activated protein kinase phosphatases that inactivates MAPKs. It dephosphorylates the phosphorylated active form of the products of rl and bsk. FBgn0260451 Alliance "Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; ganglia; and sensory nervous system primordium." FBgn0034389 FlyBase Gene Snapshot Multiple C2 domain and transmembrane region protein (Mctp) encodes a regulator of both neuronal synaptic plasticity and neurotransmitter secretion. FBgn0083938 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0083940 Alliance "Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Is expressed in several structures, including antennal anlage; gut section; head epidermis primordium; mesoderm; and visceral mesoderm derivative." FBgn0083943 Alliance Predicted to be involved in axoneme assembly. Predicted to be located in axonemal microtubule. Is expressed in spermatozoon. Orthologous to human PIERCE1 (piercer of microtubule wall 1). FBgn0083945 Alliance Is expressed in adult head. FBgn0083946 UniProtKB "Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility (By similarity). Involved in sperm motility. Required for the sperm to enter in the coiled storage seminal receptacle (SR) tubule (PubMed:21289096). (UniProtKB:Q4V516)" FBgn0083949 Alliance "Is expressed in several structures, including adult head; epithelium; presumptive embryonic/larval central nervous system; somatic muscle primordium; and spermatozoon." FBgn0083950 Alliance Is expressed in A1-7 ventral longitudinal muscle cell; abdominal intersegmental bidendritic neuron isbp; adult head; dorsal median cell; and embryonic/larval central nervous system. FBgn0083951 Alliance Is expressed in embryonic/larval visceral muscle cell. FBgn0083952 Alliance Predicted to enable DNA binding activity. FBgn0083953 Alliance Predicted to be active in mitochondrion. Orthologous to human FMC1-LUC7L2 (FMC1-LUC7L2 readthrough) and FMC1 (formation of mitochondrial complex V assembly factor 1 homolog). FBgn0083956 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). FBgn0083960 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axoneme. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 20. Orthologous to human CFAP44 (cilia and flagella associated protein 44). FBgn0083961 Alliance Orthologous to human DAZAP2 (DAZ associated protein 2). FBgn0083962 Alliance Is expressed in adult head. Orthologous to several human genes including BLTP3A (bridge-like lipid transfer protein family member 3A). FBgn0083963 FlyBase Gene Snapshot Neuroligin 3 (Nlg3) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission. FBgn0083965 FlyBase Gene Snapshot "CG34129 encodes a protein with homology to serine-type endopeptidases, but is not predicted to have catalytic activity due to mutations in its active site. It is produced in the male accessory gland and transferred to females during mating." FBgn0083966 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0083967 UniProtKB Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (UniProtKB:Q0KI28) FBgn0083968 Alliance "Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial intermembrane space protein transporter complex. Is expressed in several structures, including adult head; anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Orthologous to human TIMM13 (translocase of inner mitochondrial membrane 13)." FBgn0083969 Alliance Is expressed in organism. Orthologous to human WDR44 (WD repeat domain 44). FBgn0083973 Alliance Involved in syncytial embryo cellularization. Located in apical cortex and cellularization cleavage furrow invagination front. Is expressed in furrow canal and organism. FBgn0083975 FlyBase Gene Snapshot Neuroligin 4 (Nlg4) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission. FBgn0083976 Alliance Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Predicted to be located in mitochondrion. Is expressed in organism. Orthologous to human PUSL1 (pseudouridine synthase like 1). FBgn0083979 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult abdomen; dorsal cibarial sense organ neurons; larval abdomen; and wing. FBgn0083981 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Predicted to be located in nucleus. Is expressed in circular visceral muscle fiber and visceral muscle primordium. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3)." FBgn0083983 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL34 (mitochondrial ribosomal protein L34). FBgn0083984 Alliance Is expressed in organism. Orthologous to human C15orf61 (chromosome 15 open reading frame 61). FBgn0083985 Alliance Predicted to enable DNA binding activity. Is expressed in embryonic/larval muscle system; organism; somatic muscle primordium; and visceral muscle primordium. FBgn0083986 Alliance "Predicted to enable protein folding chaperone. Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 8. Orthologous to human LYRM7 (LYR motif containing 7)." FBgn0083987 Alliance "Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of U12-type spliceosomal complex." FBgn0083988 FlyBase Gene Snapshot C/D box small nucleolar RNA 58a (snoRNA:CD58a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3491 in 28SrRNA:CR45844. FBgn0083989 FlyBase Gene Snapshot C/D box small nucleolar RNA 58b (snoRNA:CD58b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3491 in 28SrRNA:CR45844. FBgn0083990 Alliance "Involved in male courtship behavior. Is expressed in several structures, including adult medial antennal lobe tract; antennal lobe glomerulus VA2; anterior ejaculatory duct; anterior wing margin; and sense organ." FBgn0083991 Alliance "Is expressed in several structures, including anlage in statu nascendi; embryonic central brain neurons; embryonic/larval nervous system; ganglia; and hindgut anlage." FBgn0014970 Alliance Is expressed in salivary gland. FBgn0014263 Alliance Involved in lymph gland development. FBgn0014264 Alliance Involved in imaginal disc growth. FBgn0014265 Alliance Involved in lymph gland development. FBgn0014268 Alliance Involved in lymph gland development. FBgn0014273 Alliance Involved in imaginal disc growth. FBgn0014279 Alliance Involved in lymph gland development. FBgn0013736 Alliance Involved in grooming behavior. FBgn0003523 UniProtKB "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV12) | Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV19) | Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV13) | Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV15) | Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV14) | Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV23) | Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProtKB:Q7KV22)" FBgn0011212 Alliance Is expressed in embryonic/larval tracheal section and imaginal disc. FBgn0011208 Alliance Involved in oocyte karyosome formation. FBgn0011203 Alliance Is expressed in embryonic/larval fat body. FBgn0011235 Alliance "Is expressed in several structures, including embryonic/larval brain; embryonic/larval fat body; embryonic/larval salivary gland; gut section; and ring gland." FBgn0011245 Alliance Is expressed in embryonic/larval brain; male accessory gland; male germline cell; and testis. FBgn0011256 Alliance Is expressed in embryonic/larval hindgut and gonad. FBgn0011258 Alliance Is expressed in embryonic/larval brain; embryonic/larval midgut; embryonic/larval salivary gland; and imaginal disc. FBgn0011249 Alliance Involved in chromosome organization and spermatogenesis. FBgn0011254 Alliance "Is expressed in several structures, including embryonic/larval brain; gut section; presumptive embryonic/larval system; stomodeum; and synaptic neuropil domain." FBgn0011210 Interactive Fly neuromuscular junction - regulates synaptic bouton number and maturity - regulates a noncanonical Wnt signaling pathway in the postsynaptic cell by modulating the internalization of the Wnt receptor Fz2 FBgn0011233 Alliance Involved in spermatogenesis. FBgn0015960 Alliance Is expressed in eye disc; leg disc; and wing disc. FBgn0015998 Alliance Is expressed in embryonic/larval midgut; multidendritic neurons; outer sheath cell; presumptive embryonic/larval central nervous system; and sense organ. FBgn0016030 Alliance Is expressed in embryonic/larval midgut; multidendritic neurons; outer sheath cell; presumptive embryonic/larval central nervous system; and sense organ. FBgn0016050 Alliance Involved in peripheral nervous system development. FBgn0016770 Alliance Is expressed in chordotonal neurons; embryonic/larval tracheal dorsal trunk; eo neurons; multidendritic neurons; and presumptive embryonic/larval central nervous system. FBgn0015533 Alliance Involved in peripheral nervous system development. FBgn0015559 Alliance Involved in peripheral nervous system development. FBgn0016927 Alliance Involved in olfactory behavior. FBgn0016928 Alliance Involved in olfactory behavior. FBgn0016929 Alliance Involved in olfactory behavior. FBgn0016931 Alliance Involved in olfactory behavior. FBgn0016932 Alliance Involved in olfactory behavior. FBgn0016934 Alliance Involved in olfactory behavior. FBgn0016935 Alliance Involved in olfactory behavior. FBgn0016936 Alliance Involved in olfactory behavior. FBgn0016938 Alliance Involved in olfactory behavior. FBgn0016939 Alliance Involved in olfactory behavior. FBgn0019668 Alliance Involved in female meiosis chromosome segregation. FBgn0010815 Alliance Involved in periodic partitioning. FBgn0004884 Alliance Involved in dorsal appendage formation; imaginal disc-derived wing morphogenesis; and oogenesis. FBgn0010718 Alliance Is expressed in gonad and third segment of antenna. FBgn0011431 Alliance Is expressed in embryonic/larval fat body; embryonic/larval midgut; embryonic/larval salivary gland; and gastric caecum. FBgn0011318 Alliance Involved in oogenesis. Is expressed in embryonic/larval foregut and embryonic/larval midgut. FBgn0010927 Alliance Is expressed in adult brain; adult central complex; embryonic/larval brain; and imaginal disc. FBgn0011328 Alliance Is expressed in gonad. FBgn0011367 Alliance Is expressed in embryonic/larval brain and embryonic/larval salivary gland. FBgn0011380 Alliance Is expressed in embryonic/larval fat body. FBgn0011391 Alliance Is expressed in embryonic/larval cuticle; embryonic/larval somatic muscle cell; and epidermis. FBgn0011521 Alliance Is expressed in Malpighian tubule and imaginal disc. FBgn0011805 Alliance Involved in embryonic development via the syncytial blastoderm. Is expressed in embryonic/larval brain and imaginal disc. FBgn0010457 Alliance "Is expressed in several structures, including embryonic/larval brain; embryonic/larval dorsal vessel; embryonic/larval salivary gland; epithelium; and gut section." FBgn0010461 Alliance "Is expressed in several structures, including adult central complex; brain; epithelium; gut section; and presumptive embryonic/larval system." FBgn0010463 Alliance Is expressed in embryonic/larval brain. FBgn0010465 Alliance Is expressed in adult brain; adult central complex; embryonic/larval cuticle; embryonic/larval somatic muscle cell; and epidermis. FBgn0026401 FlyBase Gene Snapshot "Nipped-B (Nipped-B) encodes a protein that interacts with the product of Mau2 to form the kollerin complex, which topologically loads the cohesin ring complex onto chromosomes. The product of Nipped-B and cohesin participate in transcriptional regulation and DNA repair." FBgn0010530 Alliance Is expressed in adult central complex; brain; embryonic/larval dorsal vessel; epidermis; and presumptive embryonic/larval system. FBgn0010662 Alliance "Is expressed in several structures, including adult central complex; brain; cephalic furrow; embryonic labral segment; and presumptive embryonic/larval system." FBgn0010587 Alliance "Is expressed in several structures, including Malpighian tubule; embryonic/larval brain; embryonic/larval pharynx; embryonic/larval tracheal system; and presumptive embryonic/larval system." FBgn0010636 Alliance "Is expressed in several structures, including embryonic/larval brain; embryonic/larval midgut; presumptive embryonic/larval system; and visceral mesoderm." FBgn0010647 Alliance Is expressed in embryonic/larval brain and imaginal disc. FBgn0010649 Alliance Is expressed in adult brain; adult central complex; adult fat body; and embryonic/larval hindgut. FBgn0013542 Alliance Is expressed in embryonic/larval posterior spiracle; embryonic/larval tracheal system; epidermis; peripheral sensory precursor cell; and sense organ. FBgn0011781 Alliance Involved in oogenesis. Is expressed in embryonic/larval brain and imaginal disc. FBgn0010693 Alliance Is expressed in Malpighian tubule; embryonic/larval fat body; embryonic/larval salivary gland; and gut section. FBgn0010714 Alliance Involved in regulation of embryonic development. FBgn0010734 Alliance Is expressed in embryonic/larval fat body. FBgn0010769 Alliance "Is expressed in several structures, including embryonic/larval brain; embryonic/larval fat body; embryonic/larval oenocyte; embryonic/larval salivary gland; and gut section." FBgn0010792 Alliance Is expressed in adult brain; adult central complex; embryonic/larval fat body; embryonic/larval hindgut; and third segment of antenna. FBgn0010816 Alliance Is expressed in Malpighian tubule; adult fat body; gastric caecum; gut section; and lamina. FBgn0010838 Alliance Is expressed in embryonic/larval brain. FBgn0010849 Alliance Involved in segmentation. FBgn0010854 Alliance Is expressed in embryonic/larval brain and imaginal disc. FBgn0010863 Alliance Is expressed in embryonic/larval brain and imaginal disc. FBgn0010866 Alliance Involved in embryonic morphogenesis. FBgn0010883 Alliance Is expressed in adult brain; adult central complex; and imaginal disc. FBgn0010897 Alliance Is expressed in embryonic/larval brain. FBgn0010923 Alliance Is expressed in adult brain; adult central complex; adult optic lobe; and embryonic/larval fat body. FBgn0010932 Alliance Is expressed in adult brain; adult central complex; adult optic lobe; embryonic/larval brain; and embryonic/larval midgut. FBgn0010939 Alliance Is expressed in embryonic/larval hindgut and embryonic/larval salivary gland. FBgn0010947 Alliance Is expressed in embryonic/larval brain; gonad; and third segment of antenna. FBgn0013595 Alliance "Is expressed in several structures, including embryonic/larval dorsal vessel; embryonic/larval somatic muscle cell; ganglia; oenocyte; and presumptive embryonic/larval central nervous system." FBgn0013596 Alliance Is expressed in adult optic lobe; embryonic brain; epidermis; larval ventral nerve cord; and third segment of antenna. FBgn0013598 Alliance Is expressed in chordotonal organ; external sensory organ; larval ventral nerve cord; and multidendritic neurons. FBgn0013601 Alliance Is expressed in chordotonal organ; embryonic brain; external sensory organ; larval ventral nerve cord; and multidendritic neurons. FBgn0013602 Alliance Is expressed in embryonic esophagus; embryonic/larval tracheal section; inclusive hindgut primordium; and presumptive embryonic/larval central nervous system. FBgn0013609 Alliance Is expressed in chordotonal neurons; eo neurons; multidendritic neurons; and presumptive embryonic/larval central nervous system. FBgn0013610 Alliance "Is expressed in several structures, including embryonic/larval anterior spiracle; embryonic/larval epipharynx; embryonic/larval esophagus; epidermis; and ventral denticle belt." FBgn0011009 Alliance Is expressed in gonad. FBgn0015959 Alliance Involved in spermatid differentiation. FBgn0261521 Alliance "Predicted to be involved in peripheral nervous system development. Is expressed in several structures, including embryonic head; embryonic/larval gut; embryonic/larval midgut primordium; embryonic/larval posterior spiracle; and epithelium." FBgn0002359 Alliance Is expressed in embryonic/larval foregut and gonad. FBgn0015552 Alliance Involved in oogenesis. FBgn0001103 Alliance Predicted to be involved in oogenesis. FBgn0016973 Alliance Is expressed in embryonic/larval lymph gland; embryonic/larval midgut; embryonic/larval posterior spiracle; and embryonic/larval salivary gland. FBgn0020283 Alliance Is expressed in embryonic/larval brain; eye disc; gonad; imaginal disc; and photoreceptor neurons. FBgn0024849 Alliance Involved in Nebenkern assembly and sperm individualization. FBgn0024853 Alliance Involved in spermatogenesis. FBgn0026213 Alliance Is expressed in embryonic/larval proventriculus. FBgn0028256 Alliance Involved in spermatid differentiation. FBgn0000554 Alliance Involved in eye-antennal disc development. FBgn0014338 Alliance Involved in larval behavior and visual behavior. FBgn0002566 FlyBase Gene Snapshot "light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis." FBgn0010172 Alliance Involved in embryonic cleavage; germarium-derived egg chamber formation; and spermatogenesis. FBgn0016976 UniProtKB "Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane. (UniProtKB:Q24211)" FBgn0016975 UniProtKB "Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane. (UniProtKB:Q24212)" FBgn0003256 FlyBase Gene Snapshot "rolled (rl) encodes the mitogen activated protein (MAP) kinase, core component of the RAS/MAPK pathway. It is inactivated by the phosphatases encoded by PTP-ER and Mkp3. It phosphorylates a diverse set of downstream cytoplasmic and nuclear effectors, which impact cell fate decisions in a wide array of tissues." FBgn0014102 Alliance Is expressed in adult head. FBgn0044385 Alliance Involved in female meiosis chromosome segregation; mitotic cell cycle; and sister chromatid cohesion. FBgn0044386 Alliance Involved in female meiosis chromosome segregation. FBgn0044387 Alliance Involved in female meiosis chromosome segregation. FBgn0044388 Alliance Involved in female meiosis chromosome segregation. FBgn0044389 Alliance Involved in female meiosis chromosome segregation. FBgn0044390 Alliance Involved in female meiosis chromosome segregation. FBgn0044391 Alliance Involved in female meiosis chromosome segregation. FBgn0044392 Alliance Involved in female meiosis chromosome segregation. FBgn0044393 Alliance Involved in female meiosis chromosome segregation. FBgn0044394 Alliance Involved in female meiosis chromosome segregation. FBgn0044395 Alliance Involved in female meiosis chromosome segregation. FBgn0044396 Alliance Involved in female meiosis chromosome segregation. FBgn0044397 Alliance Involved in female meiosis chromosome segregation. FBgn0044398 Alliance Involved in female meiosis chromosome segregation. FBgn0044399 Alliance Involved in female meiosis chromosome segregation. FBgn0044400 Alliance Involved in female meiosis chromosome segregation. FBgn0044401 Alliance Involved in female meiosis chromosome segregation. FBgn0044402 Alliance Involved in female meiosis chromosome segregation; mitotic cell cycle; and sister chromatid cohesion. FBgn0044403 Alliance Involved in female meiosis chromosome segregation and mitotic chromosome condensation. FBgn0044404 Alliance Involved in female meiosis chromosome segregation. FBgn0044405 Alliance Involved in female meiosis chromosome segregation. FBgn0044406 Alliance Involved in female meiosis chromosome segregation. FBgn0044407 Alliance Involved in female meiosis chromosome segregation. FBgn0044409 Alliance Involved in female meiosis chromosome segregation. FBgn0044410 Alliance Involved in female meiosis chromosome segregation. FBgn0044411 Alliance Involved in female meiosis chromosome segregation. FBgn0044412 Alliance Involved in female meiosis chromosome segregation. FBgn0044413 Alliance Involved in female meiosis chromosome segregation. FBgn0044414 Alliance Involved in female meiosis chromosome segregation. FBgn0044415 Alliance Involved in female meiosis chromosome segregation. Located in nucleus. FBgn0044416 Alliance Involved in female meiosis chromosome segregation. FBgn0044417 Alliance Involved in female meiosis chromosome segregation. FBgn0001200 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84040)" FBgn0045037 Alliance Involved in brain development. FBgn0045065 Alliance Involved in brain development. FBgn0032997 Alliance Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process. Is expressed in organism. Orthologous to human ASNSD1 (asparagine synthetase domain containing 1). FBgn0065114 Alliance "Involved in regulation of female receptivity, post-mating and sperm storage." FBgn0066120 Alliance Involved in mechanosensory behavior. FBgn0066128 Alliance Involved in mechanosensory behavior. FBgn0066129 Alliance Involved in mechanosensory behavior. FBgn0066132 Alliance Involved in mechanosensory behavior. FBgn0066321 Alliance Involved in behavioral response to ethanol. FBgn0066323 Alliance Involved in behavioral response to ethanol. FBgn0066324 Alliance Involved in visual learning. FBgn0066330 Alliance Involved in behavioral response to ethanol and visual learning. FBgn0066332 Alliance Involved in behavioral response to ethanol. FBgn0066361 Alliance Involved in behavioral response to ethanol. FBgn0066362 Alliance Involved in behavioral response to ethanol. FBgn0066363 Alliance Involved in behavioral response to ethanol. FBgn0066367 Alliance Involved in behavioral response to ethanol. FBgn0066372 Alliance Involved in behavioral response to ethanol. FBgn0001199 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02299)" FBgn0052218 Alliance Is expressed in organism. FBgn0069129 Alliance Involved in male meiosis chromosome segregation. FBgn0033000 Alliance Is expressed in eye. Orthologous to human ARL14EP (ADP ribosylation factor like GTPase 14 effector protein). FBgn0064225 FlyBase Gene Snapshot "Ribosomal protein L5 (RpL5) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL5 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles." FBgn0051144 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0040007 FlyBase Gene Snapshot "Ribosomal protein L38 (RpL38) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL38 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles." FBgn0001195 UniProtKB Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (UniProtKB:P02255) FBgn0001196 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P84051)" FBgn0001198 UniProtKB "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProtKB:P02283)" FBgn0011667 Alliance Located in cytoplasm and nucleus. FBgn0010247 FlyBase Gene Snapshot "Poly-(ADP-ribose) polymerase 1 (Parp1) encodes a nuclear enzyme associated with chromatin. It modifies acceptor proteins through assembly of poly(ADP-ribose) polymers. The poly(ADP-ribosyl)ating pathway regulates many nuclear functions, including DNA-repair, chromatin structure, and transcription initiation, as well as pre-mRNA fate via alternative splicing and translation." FBgn0010072 Alliance "Is expressed in several structures, including Keilin organ; adult optic lobe; central nervous system; epithelium; and gut section." FBgn0013999 Alliance Located in gap junction. Is expressed in ovary. FBgn0010013 Alliance Enables calcium-dependent cysteine-type endopeptidase activity. FBgn0015318 Alliance Enables poly-pyrimidine tract binding activity. FBgn0004628 Alliance Enables calcium ion binding activity. Is expressed in adult head; ovary; and pupal/adult digestive system. FBgn0002530 Alliance Enables aminopeptidase activity. Located in cytosol. FBgn0011821 Alliance Enables phenylalkylamine binding activity. Is expressed in adult head. FBgn0013315 Alliance Enables phenylalkylamine binding activity. Is expressed in adult head. FBgn0010085 Alliance "Located in nucleus and synapse. Is expressed in several structures, including central nervous system; ganglia; hypodermal muscle cell of A1-7; synapse; and testis." FBgn0014993 Alliance Is expressed in chordotonal organ and presumptive embryonic/larval peripheral nervous system. FBgn0016765 Alliance Is expressed in organism. FBgn0016766 Alliance Is expressed in organism. FBgn0016767 Alliance Is expressed in organism. FBgn0014959 Alliance Is expressed in male germline stem cell. FBgn0015882 Alliance Is expressed in adult head; antenna; and leg. FBgn0015883 Alliance Is expressed in adult head. FBgn0015884 Alliance Is expressed in adult head; antenna; and leg. FBgn0015885 Alliance Is expressed in adult head. FBgn0016705 Alliance Is expressed in adult head. FBgn0016706 Alliance Is expressed in adult head and organism. FBgn0016707 Alliance Is expressed in head and organism. FBgn0016708 Alliance Is expressed in adult head and organism. FBgn0016709 Alliance Is expressed in adult head and organism. FBgn0016710 Alliance Is expressed in adult head and organism. FBgn0016711 Alliance Is expressed in adult head and organism. FBgn0016712 Alliance Is expressed in adult head and organism. FBgn0016713 Alliance Is expressed in adult head and organism. FBgn0016714 Alliance Is expressed in adult head and organism. FBgn0016716 Alliance Is expressed in adult head and organism. FBgn0016717 Alliance Is expressed in adult head. FBgn0016721 Alliance Is expressed in adult head and organism. FBgn0016722 Alliance Is expressed in adult head and organism. FBgn0016723 Alliance Is expressed in adult head and organism. FBgn0014109 Alliance Is expressed in unfertilized egg. FBgn0013760 Alliance Is expressed in head. FBgn0000254 Alliance Is expressed in adult head. FBgn0014117 Alliance Is expressed in adult head and eye-antennal disc. FBgn0013397 Alliance Is expressed in adult head and eye-antennal disc. FBgn0014118 Alliance Is expressed in adult head and eye-antennal disc. FBgn0014119 Alliance Is expressed in adult head and eye-antennal disc. FBgn0014120 Alliance Is expressed in eye-antennal disc. FBgn0014121 Alliance Is expressed in eye-antennal disc. FBgn0000549 Alliance Is expressed in epidermis. FBgn0000550 Alliance Is expressed in epidermis. FBgn0017423 Alliance Is expressed in unfertilized egg. FBgn0010595 Alliance Is expressed in Malpighian tubule; embryonic/larval brain; embryonic/larval salivary gland; and imaginal disc. FBgn0010511 Alliance Is expressed in adult brain; adult central complex; embryonic/larval brain; embryonic/larval midgut; and larval insulin secreting cell of pars intercerebralis. FBgn0011330 Alliance Is expressed in embryonic/larval fat body. FBgn0010492 Alliance "Involved in embryonic development via the syncytial blastoderm. Is expressed in several structures, including epithelium; fat body; germ layer; gut section; and presumptive embryonic/larval system." FBgn0011788 Alliance Is expressed in Malpighian tubule; embryonic/larval fat body; embryonic/larval salivary gland; gastric caecum; and gut section. FBgn0011246 Alliance Is expressed in embryonic/larval brain and gonad. FBgn0010659 Alliance Is expressed in embryonic/larval brain; gonad; and imaginal disc. FBgn0025941 Alliance Is expressed in ovary. FBgn0025942 Alliance Is expressed in ovary. FBgn0020908 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in calcium-ion regulated exocytosis. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and mesothoracic tergotrochanter muscle cell. FBgn0014115 Alliance Is expressed in cephalic furrow; organism; procephalic segment; and thoracic segment. FBgn0014114 Alliance Is expressed in unfertilized egg. FBgn0014113 Alliance Is expressed in unfertilized egg. FBgn0015291 Alliance Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in embryonic/larval salivary gland. FBgn0003376 Alliance Is expressed in embryonic/larval salivary gland. FBgn0015293 Alliance Enables transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in embryonic/larval salivary gland. FBgn0024501 Alliance Is expressed in male accessory gland and male accessory gland main cell. FBgn0020885 Alliance Enables DNA binding activity. FBgn0023465 Alliance Is expressed in nurse cell and ovary. FBgn0023466 Alliance Is expressed in ovary. FBgn0041169 Alliance Is expressed in mesoderm and organism. FBgn0040486 Alliance Is expressed in hindgut proper primordium. FBgn0011288 FlyBase Gene Snapshot Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults. FBgn0028705 Alliance Located in condensed chromosome and cytoplasm. FBgn0005601 Alliance Is expressed in organism and ovary. FBgn0005603 Alliance Is expressed in organism and ovary. FBgn0005598 Alliance Is expressed in organism and ovary. FBgn0005602 Alliance "Is expressed in several structures, including central nervous system; embryonic/larval lymph gland; hindgut; imaginal disc; and ovary." FBgn0005600 Alliance "Is expressed in several structures, including central nervous system; germline cell; gut section; imaginal disc; and ovary." FBgn0005597 Alliance "Is expressed in several structures, including adult brain cell body rind; adult optic lobe; embryonic brain; germline cell; and somatic precursor cell." FBgn0005599 Alliance "Is expressed in several structures, including central nervous system; hindgut; imaginal disc; ovary; and spermatocyte." FBgn0261516 Alliance Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. FBgn0084001 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0046692 Alliance "Predicted to enable ATP binding activity. Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to several human genes including STRADB (STE20 related adaptor beta)." FBgn0039994 FlyBase Gene Snapshot conundrum (conu) encodes a Rho GTPase activating protein (RhoGAP) that negatively regulates Rho1 activity at the cell cortex via interaction with the product of Moe. FBgn0044872 Alliance Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in membrane. Orthologous to human FUT5 (fucosyltransferase 5). FBgn0040005 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). FBgn0069973 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult fat body and adult head. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0069938 Alliance Predicted to be involved in positive regulation of protein dephosphorylation. Is active in endoplasmic reticulum membrane. FBgn0058470 Alliance Predicted to be active in cytoplasm; extracellular space; and membrane. FBgn0040010 Alliance Predicted to enable calcium ion binding activity. Predicted to be involved in centriole replication. Predicted to be active in centriole; centrosome; and nucleus. Is expressed in larval ventral nerve cord and organism. Orthologous to several human genes including CETN1 (centrin 1). FBgn0058045 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is expressed in adult head. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). FBgn0082968 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0067676 Alliance Involved in oocyte growth. FBgn0067854 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0067672 Alliance Involved in oogenesis. FBgn0000262 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0045060 Alliance Involved in oogenesis. FBgn0083048 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0000225 Alliance Involved in antennal morphogenesis. FBgn0061479 Alliance Involved in bicoid mRNA localization. FBgn0017460 Alliance Predicted to be involved in transcription by RNA polymerase III. FBgn0065044 Alliance Involved in mushroom body development. FBgn0002925 Alliance Involved in oogenesis. FBgn0024258 Alliance Involved in adult walking behavior; auditory behavior; and male courtship behavior. FBgn0067648 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0004988 Alliance Involved in imaginal disc-derived wing vein morphogenesis. FBgn0082999 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0001034 Alliance Involved in pronuclear fusion. FBgn0000741 Alliance Predicted to be involved in oogenesis. FBgn0010107 Alliance Involved in head involution. FBgn0000742 Alliance Predicted to be involved in oogenesis. FBgn0016968 Alliance Predicted to be involved in peripheral nervous system development. FBgn0019658 Alliance Involved in compound eye morphogenesis. FBgn0020783 Alliance Involved in pheromone metabolic process. FBgn0045056 Alliance Involved in oogenesis. FBgn0082966 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0083018 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0026714 Alliance Involved in central nervous system development. FBgn0005685 Alliance Involved in compound eye development. FBgn0039946 UniProtKB May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA. (UniProtKB:Q86P48) FBgn0067772 Alliance Involved in egg activation. FBgn0082927 FlyBase Gene Snapshot C/D box small nucleolar RNA 33b (snoRNA:CD33b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3326 in 28SrRNA:CR45844. FBgn0067769 Alliance Involved in pole plasm oskar mRNA localization. FBgn0069246 Alliance Involved in axonogenesis and dendrite morphogenesis. FBgn0022666 Alliance Enables DNA binding activity. Located in nucleus. FBgn0016692 Alliance Involved in central nervous system development; compound eye photoreceptor development; and peripheral nervous system development. FBgn0067645 Alliance Involved in oogenesis. FBgn0046842 Alliance Involved in humoral immune response. FBgn0003473 Alliance Involved in compound eye morphogenesis and imaginal disc-derived wing margin morphogenesis. FBgn0082944 FlyBase Gene Snapshot C/D box small nucleolar RNA 52c (snoRNA:CD52c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2704 in 28SrRNA:CR45844. FBgn0082970 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0001081 Alliance Involved in mushroom body development. FBgn0016666 Alliance Enables single-stranded DNA binding activity. FBgn0026377 Alliance Predicted to enable retinoid binding activity. Located in cytoplasm. FBgn0000027 Alliance Involved in chemosensory jump behavior. FBgn0043871 Alliance Involved in sensory perception of sound. FBgn0016668 Alliance Enables single-stranded DNA binding activity. Located in nucleus. FBgn0022962 Alliance Used to study neurodegenerative disease. FBgn0020792 Alliance Involved in oogenesis. FBgn0022665 Alliance Enables DNA binding activity. Located in nucleus. FBgn0000104 Alliance Involved in muscle cell cellular homeostasis and proboscis extension reflex. FBgn0083062 Alliance Involved in cytoskeleton-dependent cytokinesis and spindle assembly. FBgn0026659 Alliance Involved in border follicle cell migration. FBgn0021751 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0003035 Alliance Involved in nuclear migration and oogenesis. FBgn0022990 Alliance Enables nuclear localization sequence binding activity. FBgn0043872 Alliance Involved in sensory perception of sound. FBgn0067776 Alliance Involved in pole plasm oskar mRNA localization. FBgn0016667 Alliance Enables single-stranded DNA binding activity. FBgn0067658 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0043595 Alliance Involved in compound eye morphogenesis. FBgn0069066 Alliance Involved in germarium-derived egg chamber formation. FBgn0013384 Alliance Involved in chemosensory jump behavior. FBgn0005686 Alliance Involved in compound eye development. FBgn0067640 Alliance Involved in pole plasm oskar mRNA localization. FBgn0001071 Alliance Involved in meiotic cell cycle. FBgn0024267 Alliance Involved in auditory behavior and male courtship behavior. FBgn0017562 Alliance Enables DNA binding activity. Located in nucleus. FBgn0004692 Alliance Involved in puparial adhesion. Located in extracellular region. FBgn0082933 FlyBase Gene Snapshot C/D box small nucleolar RNA 28c (snoRNA:CD28c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1108 and A1117 in 28SrRNA:CR45844. FBgn0022968 Alliance Located in nucleus. Part of small nuclear ribonucleoprotein complex. FBgn0022945 Alliance Enables DNA binding activity. Located in nucleus. FBgn0000167 Alliance Involved in chitin-based larval cuticle pattern formation. FBgn0067643 Alliance Involved in pole plasm oskar mRNA localization. FBgn0021754 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0015937 Alliance Predicted to enable DNA binding activity. FBgn0001237 Alliance "Involved in several processes, including dorsal appendage formation; morphogenesis of follicular epithelium; and oogenesis." FBgn0015021 Alliance Enables chromatin binding activity. FBgn0005349 Alliance Predicted to be involved in copulation. FBgn0041603 Alliance Involved in cytoskeleton-dependent cytokinesis and meiotic spindle organization. FBgn0046844 Alliance Involved in humoral immune response. FBgn0001033 Alliance Involved in embryo development. FBgn0063777 Alliance Involved in central nervous system development. FBgn0017450 Alliance Involved in axonogenesis. FBgn0015731 Alliance Involved in regulation of transcription by RNA polymerase II. FBgn0029005 Alliance Involved in dendrite morphogenesis. FBgn0045054 Alliance Involved in oogenesis. FBgn0024602 Alliance Involved in Bolwig's organ morphogenesis. FBgn0017407 Alliance Involved in axon guidance and brain development. FBgn0000062 Alliance Involved in blastoderm segmentation. FBgn0024968 Alliance Enables DNA binding activity. Located in nucleus. FBgn0022965 Alliance Located in nucleus. Part of small nuclear ribonucleoprotein complex. FBgn0028638 Alliance Involved in muscle organ development. Located in polytene chromosome puff. FBgn0028995 Alliance Involved in dendrite morphogenesis. FBgn0016793 Alliance Involved in compound eye photoreceptor development. FBgn0082936 FlyBase Gene Snapshot C/D box small nucleolar RNA 31c (snoRNA:CD31c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C2716 and A2724 in 28SrRNA:CR45844. FBgn0045062 Alliance Involved in oogenesis. FBgn0024220 Alliance Involved in positive regulation of antibacterial peptide biosynthetic process. FBgn0043555 Alliance Involved in compound eye morphogenesis. FBgn0005104 Alliance Involved in larval feeding behavior. FBgn0016725 Alliance Involved in compound eye photoreceptor development. FBgn0019653 Alliance Involved in compound eye morphogenesis. FBgn0011580 Alliance Involved in wing disc dorsal/ventral pattern formation. FBgn0028639 Alliance Involved in adult somatic muscle development; flight; and muscle organ development. Located in polytene chromosome puff. FBgn0002689 Alliance Involved in mushroom body development. FBgn0067039 Alliance Involved in wing disc development. FBgn0065113 Alliance Involved in antennal morphogenesis. FBgn0013350 Alliance Predicted to enable dUTP pyrophosphatase inhibitor activity. FBgn0083041 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0015612 Alliance Enables cysteine-type endopeptidase inhibitor activity. FBgn0022335 Alliance Involved in male meiotic nuclear division. FBgn0045050 Alliance Involved in oogenesis. FBgn0029089 Alliance Involved in dendrite morphogenesis. FBgn0010086 Interactive Fly "ß subunit of Casein kinase II - a normally inactive gene which, when active, leads to male sterility - a target of post-transcriptional gene regulation" FBgn0024259 Alliance Involved in auditory behavior and male courtship behavior. FBgn0011738 Alliance Involved in axonogenesis. FBgn0001143 Alliance Involved in nuclear migration and pole cell formation. FBgn0005687 Alliance Involved in compound eye development. FBgn0060293 Alliance Involved in temperature compensation of the circadian clock. FBgn0014370 Alliance Predicted to be located in membrane. FBgn0082967 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0067727 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0060298 Alliance Enables SH2 domain binding activity. FBgn0013445 Alliance Involved in grooming behavior. FBgn0043556 Alliance Involved in compound eye morphogenesis. FBgn0020915 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0061510 Alliance Involved in male meiosis chromosome segregation. FBgn0046706 UniProtKB "Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-4' (H3T3ph) during mitosis and interphase (PubMed:32750047). Function is essential for chromosome organization during mitosis and genome organization in interphase cells, thus playing a functional role in gene regulation (PubMed:32750047). During mitosis, may act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity). During interphase, associates with the cohesion complex and mediates pds5 binding to chromatin to ensure correct sister chromatid cohesion, chromatin organization, and also functions with Pds5-cohesin to modify Polycomb-dependent homeotic transformations (PubMed:32750047). Function during interphase is required for insulator activity, nuclear compaction, heterochromatin-induced position-effect variegation and PcG-mediated pairing-sensitive silencing (PubMed:32750047). (UniProtKB:P83103)" FBgn0019821 Alliance Involved in compound eye morphogenesis. FBgn0016042 Alliance Involved in chromosome organization; male meiotic nuclear division; and spermatogenesis. FBgn0002967 Alliance Involved in germ-band shortening; head involution; and nervous system development. FBgn0015022 Alliance Enables chromatin binding activity. FBgn0026654 Alliance Involved in border follicle cell migration. FBgn0002684 Alliance Involved in oogenesis. FBgn0083017 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0001032 Alliance Involved in embryo development. FBgn0067649 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0025870 Alliance Predicted to be involved in adult walking behavior. FBgn0008652 Alliance Involved in female meiotic nuclear division. FBgn0083094 Alliance Involved in cytoskeleton-dependent cytokinesis and meiotic spindle organization. FBgn0000367 Alliance Involved in head involution. FBgn0019683 Alliance Involved in compound eye morphogenesis. FBgn0003119 Alliance Involved in ommochrome biosynthetic process. FBgn0082947 FlyBase Gene Snapshot C/D box small nucleolar RNA 38c (snoRNA:CD38c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U1357 in 18SrRNA:CR45838. FBgn0024256 Alliance Involved in auditory behavior and male courtship behavior. FBgn0011578 Alliance Predicted to be involved in peripheral nervous system development. FBgn0039944 Alliance Is expressed in organism. FBgn0067775 Alliance Involved in egg activation. FBgn0067777 Alliance Involved in pole plasm oskar mRNA localization. FBgn0002770 Alliance Predicted to be involved in oogenesis. FBgn0001313 Alliance Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility. Is active in sperm flagellum. Is expressed in adult head. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). FBgn0026626 Alliance Involved in central nervous system development. FBgn0026202 Alliance Involved in central nervous system development. FBgn0002763 Alliance Involved in mitotic cell cycle. FBgn0026628 Alliance Involved in central nervous system development. FBgn0020523 Alliance Involved in mating behavior and pheromone biosynthetic process. FBgn0003019 Alliance Involved in chemosensory behavior. FBgn0001070 Alliance Involved in dorsal appendage formation and dorsal/ventral axis specification. FBgn0024257 Alliance Involved in auditory behavior and male courtship behavior. FBgn0045047 Alliance Involved in oogenesis. FBgn0004614 Alliance Involved in imaginal disc-derived wing vein morphogenesis. FBgn0000817 Alliance Predicted to be involved in oogenesis. FBgn0003247 Alliance Involved in compound eye development. FBgn0043554 Alliance Involved in compound eye morphogenesis. FBgn0024687 Alliance Involved in Bolwig's organ morphogenesis. FBgn0002764 Alliance Involved in mitotic cell cycle. FBgn0005105 Alliance Involved in larval feeding behavior. FBgn0039977 Alliance "Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Orthologous to human SMNDC1 (survival motor neuron domain containing 1)." FBgn0082963 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0024260 Alliance Involved in auditory behavior and male courtship behavior. FBgn0069448 Alliance Involved in dorsal closure and head involution. FBgn0043591 Alliance Involved in compound eye morphogenesis. FBgn0067767 Alliance Involved in oogenesis. FBgn0000740 Alliance Predicted to be involved in oogenesis. FBgn0069070 Alliance Involved in oogenesis. FBgn0082931 FlyBase Gene Snapshot C/D box small nucleolar RNA 53a (snoRNA:CD53a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G393 in 18SrRNA:CR45838 and G2774 in 28SrRNA:CR45844. FBgn0002892 Alliance Involved in double-strand break repair. FBgn0021757 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0000385 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0069132 Alliance Involved in male meiosis chromosome segregation. FBgn0026661 Alliance Involved in border follicle cell migration. FBgn0067657 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0045045 Alliance Involved in egg chorion assembly and oogenesis. FBgn0043593 Alliance Involved in compound eye morphogenesis. FBgn0001028 Alliance Involved in egg-laying behavior. FBgn0043594 Alliance Involved in compound eye morphogenesis. FBgn0005300 Alliance Involved in male meiotic nuclear division. FBgn0069131 Alliance Involved in male meiosis chromosome segregation. FBgn0002759 Alliance Involved in mitotic cell cycle. FBgn0000643 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0069243 Alliance Involved in spermatid nucleus differentiation. FBgn0082943 FlyBase Gene Snapshot C/D box small nucleolar RNA 27a (snoRNA:CD27a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1007 in 28SrRNA:CR45844. FBgn0043553 Alliance Involved in compound eye morphogenesis. FBgn0004653 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0044514 Alliance Is expressed in LNd neurons; adult pars intercerebralis; larval corpus cardiacum-innervating Hugin neurons; and neurosecretory neurons. FBgn0083040 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0043870 Alliance Involved in sensory perception of sound. FBgn0026660 Alliance Involved in border follicle cell migration. FBgn0020784 Alliance Enables DNA binding activity. FBgn0067646 Alliance Involved in pole plasm oskar mRNA localization. FBgn0082949 FlyBase Gene Snapshot C/D box small nucleolar RNA 38a (snoRNA:CD38a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U1357 in 18SrRNA:CR45838. FBgn0002753 Alliance Involved in mitotic cell cycle. FBgn0005395 Alliance Involved in eclosion rhythm. FBgn0082928 FlyBase Gene Snapshot C/D box small nucleolar RNA 33a (snoRNA:CD33a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3326 in 28SrRNA:CR45844. FBgn0000237 Alliance Involved in compound eye development. FBgn0005103 Alliance Involved in larval feeding behavior. FBgn0046323 Alliance Predicted to be active in cytoskeleton. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 49. Orthologous to human CFAP58 (cilia and flagella associated protein 58). FBgn0002760 Alliance Involved in mitotic cell cycle. FBgn0002755 Alliance Involved in mitotic cell cycle. FBgn0044519 Alliance Involved in oogenesis. FBgn0014272 Alliance Involved in imaginal disc growth. FBgn0040103 Alliance Predicted to enable galactose binding activity. FBgn0067654 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0024265 Alliance Involved in auditory behavior and male courtship behavior. FBgn0002754 Alliance Involved in mitotic cell cycle. FBgn0024686 Alliance Involved in Bolwig's organ morphogenesis. FBgn0003897 Alliance Predicted to be involved in olfactory learning. FBgn0016689 Alliance Involved in eye development. FBgn0025343 Alliance Enables double-stranded RNA binding activity. FBgn0016043 Alliance Involved in sperm axoneme assembly. FBgn0021753 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0027127 Alliance Is expressed in embryonic/larval somatic muscle cell and nerve. FBgn0067770 Alliance Involved in pole plasm oskar mRNA localization. FBgn0000824 Alliance Predicted to be involved in oogenesis. FBgn0015317 Alliance "Involved in mRNA splicing, via spliceosome. Located in nucleoplasm." FBgn0000200 Alliance Involved in Malpighian tubule morphogenesis. FBgn0026648 Alliance Involved in border follicle cell migration. FBgn0067328 Alliance Involved in wing disc development. FBgn0011599 Alliance Involved in axonogenesis. FBgn0045061 Alliance Involved in oogenesis. FBgn0022360 Alliance Enables calcium ion binding activity. FBgn0024264 Alliance Involved in auditory behavior and male courtship behavior. FBgn0083087 Alliance Involved in determination of adult lifespan and mitochondrion organization. FBgn0024208 Alliance Involved in eye-antennal disc development. FBgn0083091 Alliance Involved in meiosis I cytokinesis and meiosis II cytokinesis. FBgn0045049 Alliance Involved in oogenesis. FBgn0021584 Alliance Enables damaged DNA binding activity. Located in nucleus. FBgn0045053 Alliance Involved in oogenesis. FBgn0069069 Alliance Involved in oogenesis. FBgn0004662 Alliance Involved in mushroom body development. FBgn0000103 Alliance Involved in proboscis extension reflex. FBgn0026165 Alliance Involved in central nervous system development. FBgn0082951 FlyBase Gene Snapshot C/D box small nucleolar RNA 40 (snoRNA:CD40) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C1367 in 18SrRNA:CR45838. FBgn0043869 Alliance Involved in sensory perception of sound. FBgn0026651 Alliance Involved in border follicle cell migration. FBgn0028989 Alliance Involved in dendrite morphogenesis. FBgn0041722 Alliance Involved in defense response. FBgn0082969 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0015516 Alliance Involved in chromosome organization and spermatogenesis. FBgn0000234 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0024615 Alliance Involved in Bolwig's organ morphogenesis. FBgn0000769 Alliance Predicted to be involved in oogenesis. FBgn0001052 Alliance Involved in embryonic cleavage. FBgn0028637 Alliance Involved in muscle organ development. Located in polytene chromosome puff. FBgn0039945 Alliance Is expressed in organism and photoreceptor neurons. FBgn0020790 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0082932 FlyBase Gene Snapshot C/D box small nucleolar RNA 28d (snoRNA:CD28d) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1108 and A1117 in 28SrRNA:CR45844. FBgn0046843 Alliance Involved in humoral immune response. FBgn0067663 Alliance Involved in oogenesis. FBgn0043592 Alliance Involved in compound eye morphogenesis. FBgn0024433 Alliance Involved in germ cell migration and gonadal mesoderm development. FBgn0024262 Alliance Involved in auditory behavior and male courtship behavior. FBgn0019639 Alliance Involved in DNA repair. FBgn0043557 Alliance Involved in compound eye morphogenesis. FBgn0084556 Alliance Involved in adult locomotory behavior. FBgn0040101 Alliance Predicted to enable galactose binding activity. FBgn0025104 Alliance Enables calcium-dependent cysteine-type endopeptidase activity. Involved in proteolysis. FBgn0017403 Alliance Involved in axonogenesis. FBgn0003018 Alliance Involved in chemosensory behavior. FBgn0022667 Alliance Enables DNA binding activity. Located in nucleus. FBgn0067766 Alliance Involved in pole plasm oskar mRNA localization. FBgn0005681 Alliance Involved in compound eye development. FBgn0000415 Alliance Predicted to be involved in embryonic development via the syncytial blastoderm. FBgn0000214 Alliance Involved in oogenesis. FBgn0082926 FlyBase Gene Snapshot C/D box small nucleolar RNA 46 (snoRNA:CD46) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U586 in 18SrRNA:CR45838. FBgn0004965 Alliance Involved in imaginal disc-derived wing margin morphogenesis. FBgn0024804 FlyBase Gene Snapshot "Dead box protein 80 (Dbp80) encodes a putative ATP-dependent RNA helicase (DEAD box helicase), based on sequence similarity to other Dead box proteins, which are involved in mRNA export from the nucleus." FBgn0064245 Alliance Involved in telomere maintenance. FBgn0025105 Alliance Enables calcium-dependent cysteine-type endopeptidase activity. Involved in proteolysis. FBgn0063368 FlyBase Gene Snapshot Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. FBgn0045048 Alliance Involved in oogenesis. FBgn0028580 Alliance Involved in spermatogenesis. FBgn0045058 Alliance Involved in oogenesis. FBgn0002752 Alliance Involved in mitotic cell cycle. FBgn0000282 Alliance Predicted to be involved in male courtship behavior. FBgn0069923 Alliance Enables structural molecule activity. Involved in cristae formation. Part of MICOS complex. Is expressed in adult head; adult heart; and organism. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). FBgn0045059 Alliance Involved in oogenesis. FBgn0017404 Alliance Involved in axonogenesis. FBgn0082940 FlyBase Gene Snapshot C/D box small nucleolar RNA 54a (snoRNA:CD54a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3298 in 28SrRNA:CR45844. FBgn0083016 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0020781 Alliance Involved in pheromone metabolic process. FBgn0067652 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0000642 Alliance Involved in egg chorion assembly. FBgn0082914 Alliance Involved in sperm DNA decondensation; sperm entry; and sperm storage. FBgn0002762 Alliance Involved in mitotic cell cycle. FBgn0021586 Alliance Enables DNA endonuclease activity and damaged DNA binding activity. Located in nucleus. FBgn0016942 Alliance Predicted to be involved in peripheral nervous system development. FBgn0058064 Alliance Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Is expressed in spermatozoon. FBgn0069444 Alliance Involved in dorsal closure and head involution. FBgn0067401 Alliance Involved in response to DDT. FBgn0004075 Alliance Involved in spermatogenesis. FBgn0019805 Alliance Involved in compound eye morphogenesis; imaginal disc-derived wing margin morphogenesis; and imaginal disc-derived wing vein morphogenesis. FBgn0015020 Alliance Enables chromatin binding activity. FBgn0000361 Alliance A structural constituent of egg chorion. Involved in egg chorion assembly. FBgn0082583 Alliance Involved in behavioral response to ethanol. FBgn0015231 Alliance "Involved in anterior/posterior axis specification, embryo; imaginal disc-derived wing vein morphogenesis; and regulation of syncytial blastoderm mitotic cell cycle." FBgn0000580 Alliance Involved in gastrulation involving germ band extension and imaginal disc development. FBgn0067774 Alliance Involved in egg activation. FBgn0043558 Alliance Involved in compound eye morphogenesis. FBgn0028994 Alliance Involved in dendrite morphogenesis. FBgn0069068 Alliance Involved in oogenesis. FBgn0067671 Alliance Involved in oogenesis. FBgn0028636 Alliance Involved in muscle organ development. Located in polytene chromosome puff. FBgn0001175 Alliance Involved in Malpighian tubule morphogenesis and embryonic development via the syncytial blastoderm. FBgn0024266 Alliance Involved in auditory behavior and male courtship behavior. FBgn0084678 Alliance Involved in adult locomotory behavior. FBgn0024600 Alliance Involved in axon guidance. FBgn0083050 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0011679 Alliance Enables single-stranded DNA binding activity. FBgn0000154 Alliance "Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in imaginal disc-derived leg segmentation and positive regulation of transcription by RNA polymerase II. Located in nucleus." FBgn0017416 Alliance Involved in axonogenesis. FBgn0067329 Alliance Involved in imaginal disc-derived wing margin morphogenesis. FBgn0024697 Alliance Involved in photoreceptor cell fate commitment. FBgn0002648 Alliance Involved in mitotic cell cycle. FBgn0014190 Alliance Predicted to be involved in mating behavior. FBgn0044422 Alliance Involved in eye photoreceptor cell differentiation. FBgn0020867 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0010104 Alliance Involved in behavioral response to ethanol. Used to study alcohol use disorder. FBgn0013465 Alliance Involved in grooming behavior. FBgn0003905 Alliance Predicted to be involved in oogenesis. FBgn0043596 Alliance Involved in compound eye morphogenesis. FBgn0069127 Alliance Involved in male meiosis chromosome segregation. FBgn0024219 Alliance Involved in positive regulation of antibacterial peptide biosynthetic process. FBgn0024305 Alliance Involved in rhabdomere development. FBgn0082919 FlyBase Gene Snapshot C/D box small nucleolar RNA 61 (snoRNA:CD61) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0027639 Alliance Involved in female meiotic nuclear division. FBgn0022356 Alliance Enables TBP-class protein binding activity. Involved in transcription by RNA polymerase III. Part of transcription factor TFIIIB complex. FBgn0067050 Alliance Involved in response to DDT and response to organophosphorus. FBgn0016682 Alliance Enables single-stranded DNA binding activity. Located in cytoplasm. FBgn0013739 Alliance Involved in grooming behavior. FBgn0082929 FlyBase Gene Snapshot C/D box small nucleolar RNA 53c (snoRNA:CD53c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G2774 in 28SrRNA:CR45844. FBgn0082972 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0022334 Alliance Involved in male meiotic nuclear division. FBgn0082937 FlyBase Gene Snapshot C/D box small nucleolar RNA 31b (snoRNA:CD31b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C2716 and A2724 in 28SrRNA:CR45844. FBgn0001004 Alliance Involved in egg chorion assembly and vitelline membrane formation involved in chorion-containing eggshell formation. FBgn0015760 Alliance Part of microtubule associated complex. Is expressed in amnioserosa; connective; larval longitudinal connective; organism; and presumptive embryonic/larval central nervous system. FBgn0024359 Alliance Involved in compound eye morphogenesis. FBgn0082941 FlyBase Gene Snapshot C/D box small nucleolar RNA 45 (snoRNA:CD45) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1017 in 28SrRNA:CR45844. FBgn0043046 Alliance Involved in maintenance of centrosome location; regulation of exit from mitosis; and regulation of syncytial blastoderm mitotic cell cycle. FBgn0084745 Alliance "Involved in primary branching, open tracheal system." FBgn0005577 Alliance Involved in chemosensory behavior. FBgn0026653 Alliance Involved in border follicle cell migration. FBgn0000160 Alliance Involved in mechanosensory behavior. FBgn0000026 Alliance Involved in chemosensory jump behavior. FBgn0000102 Alliance Involved in proboscis extension reflex. FBgn0082950 FlyBase Gene Snapshot C/D box small nucleolar RNA 42 (snoRNA:CD42) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0004490 Alliance Predicted to be involved in negative regulation of female receptivity. FBgn0067778 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0083000 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0003158 Alliance Predicted to be involved in oogenesis. FBgn0040020 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. (UniProtKB:Q9W5P1)" FBgn0001144 Alliance Involved in nuclear migration. FBgn0024263 Alliance Involved in auditory behavior and male courtship behavior. FBgn0013385 Alliance Involved in chemosensory jump behavior. FBgn0064190 Alliance Involved in pole plasm assembly. FBgn0067675 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0004981 Alliance Involved in imaginal disc-derived wing morphogenesis. FBgn0024599 Alliance Involved in Bolwig's organ morphogenesis. FBgn0060297 Alliance Enables SH2 domain binding activity. FBgn0000814 Alliance Predicted to be involved in oogenesis. FBgn0000248 Alliance Predicted to be involved in olfactory learning. FBgn0016663 Alliance Enables single-stranded DNA binding activity. FBgn0000101 Alliance Involved in imaginal disc-derived wing margin morphogenesis. FBgn0000779 Alliance Predicted to be involved in oogenesis. FBgn0019638 Alliance Enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in DNA repair. FBgn0003991 Alliance Involved in oogenesis. FBgn0005584 Alliance Enables protein serine/threonine kinase activity. Predicted to be extrinsic component of plasma membrane. FBgn0016664 Alliance Enables single-stranded DNA binding activity. Located in nucleus. FBgn0026649 Alliance Involved in border follicle cell migration. FBgn0082946 FlyBase Gene Snapshot C/D box small nucleolar RNA 52a (snoRNA:CD52a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2704 in 28SrRNA:CR45844. FBgn0058263 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Is expressed in adult head. FBgn0067780 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0000300 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0044423 Alliance Involved in eye photoreceptor cell differentiation. FBgn0019823 Alliance Involved in compound eye morphogenesis. FBgn0061516 Alliance Involved in embryonic development via the syncytial blastoderm. FBgn0066318 Alliance Involved in mushroom body development. FBgn0019912 Alliance Enables protein heterodimerization activity. Contributes to DNA binding activity. Part of Ku70:Ku80 complex. FBgn0022970 Alliance Located in nucleus. Part of small nuclear ribonucleoprotein complex. FBgn0013466 Alliance Involved in grooming behavior. FBgn0046845 Alliance Involved in humoral immune response. FBgn0002710 Alliance Involved in female meiosis chromosome segregation and reciprocal meiotic recombination. FBgn0043850 Alliance Involved in compound eye morphogenesis. FBgn0024221 Alliance Involved in positive regulation of antibacterial peptide biosynthetic process. FBgn0002553 Alliance Enables dihydropterin oxidase activity. FBgn0044425 Alliance Involved in establishment of ommatidial planar polarity. FBgn0000450 Alliance Involved in determination of left/right symmetry and oogenesis. FBgn0019822 Alliance Involved in compound eye morphogenesis. FBgn0022735 Alliance Predicted to be involved in response to hypoxia. FBgn0082939 FlyBase Gene Snapshot C/D box small nucleolar RNA 54b (snoRNA:CD54b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3298 in 28SrRNA:CR45844. FBgn0003020 Alliance Involved in chemosensory behavior. FBgn0067651 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0001051 Alliance Involved in embryonic cleavage and pronuclear fusion. FBgn0003951 Alliance Involved in adult locomotory behavior; oogenesis; and sensory perception of sound. FBgn0000756 Alliance Predicted to be involved in oogenesis. FBgn0067653 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0046698 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in organism and testis. FBgn0067331 Alliance Involved in imaginal disc-derived wing vein specification. FBgn0067773 Alliance Involved in egg activation. FBgn0002683 Alliance Involved in oogenesis. FBgn0001214 Alliance Involved in olfactory behavior. FBgn0002893 Alliance Involved in double-strand break repair. FBgn0019685 Alliance Involved in mushroom body development. FBgn0046841 Alliance Involved in humoral immune response. FBgn0069130 Alliance Involved in male meiosis chromosome segregation. FBgn0040973 Alliance Orthologous to human TMA7 (translation machinery associated 7 homolog). FBgn0015365 Alliance Involved in thermosensory behavior. FBgn0015508 Alliance "Predicted to be involved in terminal branching, open tracheal system." FBgn0067659 Alliance Involved in pole plasm oskar mRNA localization. FBgn0002903 Alliance Involved in double-strand break repair. FBgn0014978 Alliance Involved in nervous system development. FBgn0002761 Alliance Involved in mitotic cell cycle. FBgn0016669 Alliance Enables single-stranded DNA binding activity. FBgn0067647 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0002714 Alliance Involved in female meiotic nuclear division and mitotic cell cycle. FBgn0004492 Alliance Enables dihydropterin oxidase activity. Involved in dihydropteridine metabolic process. FBgn0011561 Alliance Involved in imaginal disc growth. FBgn0065972 Alliance Involved in mushroom body development. FBgn0045044 Alliance Involved in oogenesis. FBgn0017563 Alliance Enables DNA binding activity. Located in nucleus. FBgn0067655 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0024185 Alliance Involved in germ cell migration. FBgn0000059 Alliance Involved in gonad development. FBgn0020654 Alliance "Located in female germline ring canal outer rim. Is expressed in several structures, including follicle cell; germarium; ovariole; testis; and vitellarium." FBgn0082938 FlyBase Gene Snapshot C/D box small nucleolar RNA 31a (snoRNA:CD31a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C2716 and A2724 in 28SrRNA:CR45844. FBgn0028635 Alliance Involved in muscle organ development. Located in polytene chromosome puff. FBgn0026650 Alliance Involved in border follicle cell migration. FBgn0019657 Alliance Involved in compound eye morphogenesis. FBgn0045055 Alliance Involved in oogenesis. FBgn0039993 Alliance Predicted to enable catalytic activity. Predicted to contribute to 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity and branched-chain alpha-keto acid dehydrogenase activity. Predicted to be involved in branched-chain amino acid catabolic process and response to nutrient. Predicted to be located in mitochondrion. Predicted to be part of oxoglutarate dehydrogenase complex. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHB (branched chain keto acid dehydrogenase E1 subunit beta). FBgn0083049 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0013383 Alliance Involved in chemosensory jump behavior. FBgn0004061 Alliance Involved in oocyte anterior/posterior axis specification. FBgn0024224 Alliance Involved in positive regulation of antibacterial peptide biosynthetic process. FBgn0016997 Alliance Involved in axon guidance. FBgn0023088 Alliance Used to study neurodegenerative disease. FBgn0082934 FlyBase Gene Snapshot C/D box small nucleolar RNA 28b (snoRNA:CD28b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1108 and A1117 in 28SrRNA:CR45844. FBgn0067638 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0000354 Alliance Involved in imaginal disc-derived wing morphogenesis. FBgn0043559 Alliance Involved in compound eye morphogenesis. FBgn0067656 Alliance Involved in neuron-neuron synaptic transmission and phototaxis. FBgn0064155 Alliance Involved in nuclear axial expansion; nuclear cortical migration; and regulation of preblastoderm mitotic cell cycle. FBgn0083042 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0082952 FlyBase Gene Snapshot C/D box small nucleolar RNA 24 (snoRNA:CD24) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1061 in 18SrRNA:CR45838. FBgn0013970 Alliance Enables sequence-specific DNA binding activity. Located in nucleus. FBgn0028634 Alliance Involved in muscle organ development. Located in polytene chromosome puff. FBgn0022384 Alliance Predicted to enable nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in cytosol and nucleus. FBgn0084970 Alliance "Involved in primary branching, open tracheal system." FBgn0021775 Alliance Involved in male meiotic nuclear division. FBgn0040100 Alliance Predicted to enable galactose binding activity. FBgn0010272 Alliance Predicted to enable DNA binding activity. Predicted to be located in nucleus. FBgn0025736 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0067768 Alliance Involved in bicoid mRNA localization. FBgn0024601 Alliance Involved in axon guidance. FBgn0043597 Alliance Involved in compound eye morphogenesis. FBgn0001049 Alliance Involved in pronuclear fusion. FBgn0014267 Alliance Involved in imaginal disc growth. FBgn0002546 Alliance Involved in dorsal closure. FBgn0005106 Alliance Involved in larval feeding behavior. FBgn0082971 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0024893 Alliance Involved in Nebenkern assembly and sperm individualization. FBgn0002946 Alliance Involved in response to pain. FBgn0002713 Alliance Involved in male meiotic nuclear division. FBgn0001054 Alliance Involved in embryonic cleavage. FBgn0046697 Alliance Predicted to be active in cilium. Orthologous to human DRC3 (dynein regulatory complex subunit 3). FBgn0014355 Alliance Involved in sperm axoneme assembly. FBgn0069128 Alliance Involved in male meiosis chromosome segregation. FBgn0082945 FlyBase Gene Snapshot C/D box small nucleolar RNA 52b (snoRNA:CD52b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2704 in 28SrRNA:CR45844. FBgn0065988 Alliance Involved in mushroom body development. FBgn0022967 Alliance Located in nucleus. Part of small nuclear ribonucleoprotein complex. FBgn0043857 Alliance Involved in sensory perception of sound. FBgn0020798 Alliance Involved in oogenesis. FBgn0021755 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0082948 FlyBase Gene Snapshot C/D box small nucleolar RNA 38b (snoRNA:CD38b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U1357 in 18SrRNA:CR45838. FBgn0023428 Alliance Is expressed in segment border muscle cell. FBgn0043467 Alliance Involved in behavioral response to ethanol. FBgn0016690 Alliance Involved in eye-antennal disc development. FBgn0082930 FlyBase Gene Snapshot C/D box small nucleolar RNA 53b (snoRNA:CD53b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G2774 in 28SrRNA:CR45844. FBgn0045057 Alliance Involved in oogenesis. FBgn0004968 Alliance Involved in oogenesis. FBgn0024268 Alliance Involved in auditory behavior and male courtship behavior. FBgn0000501 Alliance Involved in Malpighian tubule morphogenesis and embryonic development via the syncytial blastoderm. FBgn0022333 Alliance Involved in male meiotic nuclear division. FBgn0027952 Alliance Involved in male meiosis chromosome segregation. FBgn0002756 Alliance Involved in mitotic cell cycle. FBgn0025918 Alliance Involved in female meiosis chromosome segregation and reciprocal meiotic recombination. FBgn0001073 Alliance Involved in pronuclear fusion. FBgn0004023 Alliance Involved in sperm axoneme assembly. FBgn0082942 FlyBase Gene Snapshot C/D box small nucleolar RNA 27b (snoRNA:CD27b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1007 in 28SrRNA:CR45844. FBgn0082600 Alliance Involved in behavioral response to ethanol. FBgn0005286 Alliance Involved in female meiotic nuclear division. FBgn0045051 Alliance Involved in oogenesis. FBgn0001060 Alliance Involved in embryonic cleavage. FBgn0003243 Alliance Predicted to be involved in oogenesis. FBgn0041730 Alliance Involved in adult locomotory behavior. FBgn0028973 Alliance Involved in dendrite morphogenesis. FBgn0022780 Alliance Involved in response to hypoxia. FBgn0004963 Alliance Involved in cuticle pattern formation and oogenesis. FBgn0013382 Alliance Involved in chemosensory jump behavior. FBgn0085071 Alliance Involved in adult locomotory behavior. FBgn0082935 FlyBase Gene Snapshot C/D box small nucleolar RNA 28a (snoRNA:CD28a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1108 and A1117 in 28SrRNA:CR45844. FBgn0045046 Alliance Involved in oogenesis. FBgn0083006 Alliance Predicted to enable rRNA pseudouridylation guide activity. Involved in snoRNA guided rRNA pseudouridine synthesis. Is active in nucleolus. FBgn0026623 Alliance Involved in central nervous system development; embryonic development via the syncytial blastoderm; and midgut development. FBgn0017417 Alliance Involved in axonogenesis. FBgn0020295 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0082998 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0016916 Alliance Predicted to be involved in peripheral nervous system development. FBgn0069969 Alliance Is expressed in adult head. FBgn0044056 Alliance Enables DNA binding activity. Located in nucleus. FBgn0005537 Alliance Involved in spermatogenesis. FBgn0083047 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0026657 Alliance Involved in border follicle cell migration. FBgn0043905 Alliance Involved in meiosis I cytokinesis and meiosis II cytokinesis. FBgn0003994 Alliance Involved in muscle organ development and striated muscle tissue development. FBgn0002758 Alliance Involved in mitotic cell cycle. FBgn0044424 Alliance Involved in establishment of ommatidial planar polarity and eye photoreceptor cell differentiation. FBgn0002583 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. FBgn0000590 Alliance Involved in mechanosensory behavior. FBgn0021756 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces. FBgn0003110 Alliance Involved in chaeta morphogenesis. FBgn0066317 Alliance Involved in mushroom body development. FBgn0020660 FlyBase Gene Snapshot "eukaryotic translation initiation factor 4B (eIF4B) encodes a protein involved in cap-dependent translation, cell survival, and proliferation." FBgn0003524 Alliance Involved in gastrulation involving germ band extension and head involution. FBgn0001063 Alliance Involved in embryo development. FBgn0063393 Alliance Involved in cystoblast division; oogenesis; and spermatogenesis. FBgn0025919 Alliance Involved in female meiosis chromosome segregation and reciprocal meiotic recombination. FBgn0000745 Alliance Predicted to be involved in oogenesis. FBgn0024261 Alliance Involved in auditory behavior and male courtship behavior. FBgn0066057 Alliance Involved in mushroom body development. FBgn0021585 Alliance Enables damaged DNA binding activity. Located in nucleus. FBgn0027097 Alliance Involved in border follicle cell migration. FBgn0020777 Alliance Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces and embryonic morphogenesis. FBgn0043588 Alliance Involved in compound eye morphogenesis and imaginal disc-derived wing morphogenesis. FBgn0044426 Alliance Involved in eye photoreceptor cell differentiation. FBgn0005680 Alliance Involved in compound eye development. FBgn0020609 Alliance Involved in axon guidance and axonal fasciculation. FBgn0017461 Alliance Predicted to be involved in transcription by RNA polymerase III. FBgn0002757 Alliance Involved in mitotic cell cycle. FBgn0045052 Alliance Involved in oogenesis. FBgn0001029 Alliance Involved in embryo development. FBgn0011574 Alliance Involved in larval foraging behavior. FBgn0045043 Alliance Involved in oogenesis. FBgn0067644 Alliance Involved in oogenesis. FBgn0067641 Alliance Involved in bicoid mRNA localization and pole plasm oskar mRNA localization. FBgn0004969 Alliance Involved in oogenesis. FBgn0000025 Alliance Involved in chemosensory jump behavior. FBgn0085190 Alliance Predicted to enable acylphosphatase activity. Orthologous to human ACYP1 (acylphosphatase 1). FBgn0085193 Alliance "Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm." FBgn0085195 Alliance Is expressed in adult head and embryonic/larval fat body. FBgn0085200 Alliance Predicted to be involved in proteolysis. FBgn0085201 Alliance Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be part of mitochondrial respirasome. Is expressed in adult head. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1); COX7A2 (cytochrome c oxidase subunit 7A2); and COX7A2L (cytochrome c oxidase subunit 7A2 like). FBgn0085203 Alliance Orthologous to human CINP (cyclin dependent kinase 2 interacting protein). FBgn0085206 Alliance Predicted to be located in extracellular space. FBgn0085208 Alliance "Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; embryonic/larval muscle system; gut section; and mesoderm." FBgn0085211 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in maturation of SSU-rRNA and ribosomal small subunit assembly. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. FBgn0085212 UniProtKB Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. (UniProtKB:A8DYY5) FBgn0085217 Alliance Is expressed in adult head. FBgn0085218 Alliance Predicted to enable protein homodimerization activity. Predicted to be located in endoplasmic reticulum. FBgn0085220 UniProtKB "Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity). The so-called ufmylation, requires the UFM1-activating E1 enzyme Uba5, the UFM1-conjugating E2 enzyme Ufc1, and the UFM1-ligase E3 enzyme Ufl1 (By similarity). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (By similarity). The Ufm1 cascade might play a role in the development of the neuromuscular junctions (PubMed:26872069). (UniProtKB:A8DYH2)" FBgn0085223 Alliance Predicted to be part of serine palmitoyltransferase complex. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B). FBgn0085224 Alliance "Predicted to enable tRNA (cytidine) methyltransferase activity. Predicted to be involved in tRNA methylation. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human METTL6 (methyltransferase 6, tRNA N3-cytidine)." FBgn0085229 Alliance Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein targeting to mitochondrion. Part of mitochondrial outer membrane translocase complex. Is active in mitochondrial outer membrane. FBgn0085234 Alliance Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adult head. FBgn0085242 Alliance Is expressed in organism. Orthologous to human NR2C2AP (nuclear receptor 2C2 associated protein). FBgn0085249 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in adult head. FBgn0085253 Alliance Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. FBgn0085256 Alliance Located in extracellular space. Is expressed in embryonic/larval hemolymph. FBgn0085257 Alliance Is expressed in adult head and adult heart. Orthologous to human SMIM12 (small integral membrane protein 12). FBgn0085260 Alliance Predicted to enable nucleic acid binding activity. Orthologous to human RBM48 (RNA binding motif protein 48). FBgn0085261 Alliance Is expressed in embryonic/larval posterior spiracle and posterior spiracle primordium. FBgn0085271 Alliance Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human SMIM20 (small integral membrane protein 20). FBgn0085284 UniProtKB Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (UniProtKB:A8JNV4) FBgn0085288 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0085290 Alliance Predicted to enable ADP-ribosylglutamate hydrolase activity and purine nucleoside binding activity. Predicted to be involved in purine nucleoside metabolic process. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). FBgn0085300 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0085303 Alliance Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. FBgn0085305 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. FBgn0085306 Alliance Is expressed in organism. FBgn0085311 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0085312 Alliance Orthologous to human GTSF1 (gametocyte specific factor 1). FBgn0085313 Alliance Is expressed in adult head. FBgn0085318 Alliance Predicted to enable zinc ion binding activity. FBgn0085319 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0085322 Alliance Predicted to be part of serine palmitoyltransferase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 90A and hereditary spastic paraplegia 90B. Orthologous to several human genes including SPTSSB (serine palmitoyltransferase small subunit B). FBgn0085324 Alliance Predicted to be involved in proteolysis. FBgn0085326 Alliance Predicted to enable molecular adaptor activity. Predicted to be involved in axonemal dynein complex assembly; response to heat; and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. FBgn0085337 Alliance Predicted to enable ubiquitin protein ligase activity and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in ERAD pathway and ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. FBgn0085339 Alliance Is expressed in germline cell; gonad; organism; and primordial germ cell. FBgn0085343 FlyBase Gene Snapshot "SWIM domain containing Srs2 interacting protein 1 (Sws1) encodes a protein that is paralog-interacting of the product of spn-A. It is involved in homologous recombination in the repair of double-strand breaks, likely through the product of spn-A regulation." FBgn0085345 Alliance Predicted to be active in extracellular space. FBgn0085346 Alliance Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex. Predicted to be active in nucleolus. Orthologous to human RPP14 (ribonuclease P/MRP subunit p14). FBgn0085350 FlyBase Gene Snapshot "inaF-C (inaF-C) encodes one of the four isoforms at the InaF locus, which contains four small ORFs named inaF-A, inaF-B, inaF-C, and inaF-D, each of which is spliced to the same down-stream exon. Mutations in inaF-C and inaF-B greatly suppress the expression of photoreceptor channel protein trp. inaF-C and inaF-B co-immunolocalize with trp to the rhabdomeres, structures containing the photoreceptors." FBgn0085351 FlyBase Gene Snapshot "inaF-A (inaF-A) encodes one of the four isoforms at the InaF locus, which contains four small ORFs named inaF-A, inaF-B, inaF-C, and inaF-D, each of which is spliced to the same down-stream exon. inaF-A is involved in the response to light stimulus." FBgn0085353 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in adult head. FBgn0085354 Alliance Orthologous to human FHL2 (four and a half LIM domains 2) and FHL5 (four and a half LIM domains 5). FBgn0085358 Alliance Predicted to be located in extracellular space. Is expressed in adult head and adult heart. FBgn0085359 Alliance Is expressed in amnioserosa. FBgn0085362 FlyBase Gene Snapshot Vitelline membrane-like (Vml) encodes a structural component of the vitelline membrane. It forms part of a localized structural signal that controls the formation and polarity of the dorsal-ventral axis of the embryo. FBgn0085369 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human DRGX (dorsal root ganglia homeobox)." FBgn0085370 UniProtKB "Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Dual-specificity phosphodiesterase that catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. (UniProtKB:Q9VJ79)" FBgn0085371 Alliance Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. FBgn0085374 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. FBgn0085376 Alliance Predicted to be involved in actomyosin structure organization. Predicted to be active in cytoskeleton. Is expressed in embryonic/larval midgut primordium. Orthologous to human EPB41L4A (erythrocyte membrane protein band 4.1 like 4A). FBgn0085377 Alliance Predicted to enable acyltransferase activity. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human TMEM68 (transmembrane protein 68). FBgn0085380 Alliance Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection. Is expressed in adult head. Orthologous to human RGS7BP (regulator of G protein signaling 7 binding protein). FBgn0085382 Alliance Predicted to enable axon guidance receptor activity. Involved in gravitaxis. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in adult head. FBgn0085383 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA processing. Predicted to be located in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). FBgn0085384 Alliance "Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin)." FBgn0085385 FlyBase Gene Snapshot black match (bma) encodes a protein involved in heat sensitivity. FBgn0085386 Alliance "Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to several human genes including GUCY2F (guanylate cyclase 2F, retinal)." FBgn0085387 UniProtKB Structural component of the gap junctions at electrical synapses in distal and mid-depth levels in the lamina. Isoform Lethal forms voltage sensitive intercellular channels through homotypic interactions. (UniProtKB:P33085) FBgn0085390 UniProtKB "Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity). May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons. (UniProtKB:Q01583)" FBgn0085391 Alliance "Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein)." FBgn0085395 Alliance "Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in several cellular components, including dendrite membrane; neuronal cell body membrane; and synaptic membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2) and KCNC4 (potassium voltage-gated channel subfamily C member 4)." FBgn0085396 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Leri-Weill dyschondrosteosis; SHOX-related short stature; and lung cancer. Orthologous to several human genes including SHOX (SHOX homeobox)." FBgn0085397 FlyBase Gene Snapshot Fish-lips (Fili) encodes a leucine-rich repeat family transmembrane protein. It regulates autonomous and nonautonomous apoptosis caused by the dioxin receptor homolog encoded by ss. FBgn0085398 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0085399 Alliance Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; and yolk nucleus. FBgn0085400 Alliance Is expressed in adult head. FBgn0085404 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be active in cytoplasm. Is expressed in dorsal head epidermis; embryonic rectum; and embryonic/larval posterior spiracle. FBgn0085405 Alliance Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in amnioserosa; gut section; trunk mesoderm; visceral mesoderm derivative; and yolk nucleus. FBgn0085408 UniProtKB "Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction (PubMed:20549743, PubMed:22493320). During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826). May be involved in the assembly of microtubule arrays during cell elongation (By similarity). (UniProtKB:A1Z9P3)" FBgn0085409 FlyBase Gene Snapshot smoke alarm (smal) encodes a protein involved in thermal nociception. FBgn0085410 UniProtKB "G-protein coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels. (UniProtKB:Q9VML9)" FBgn0085412 Interactive Fly "regulates Wnt signaling by antagonizing Kelch, a Cullin-3 E3 ligase adaptor that mediates Dishevelledpolyubiquitination" FBgn0085413 UniProtKB Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). (UniProtKB:A8JQ65) FBgn0085414 Alliance Involved in synapse organization and synaptic target recognition. Predicted to be active in neuron projection membrane. Is expressed in embryonic head sensory system; larval ventral nerve cord; and ventral nerve cord primordium. FBgn0085417 FlyBase Gene Snapshot natalisin (natalisin) encodes five signaling peptides with potent agonist activities toward the product of TkR86C. FBgn0085419 FlyBase Gene Snapshot "Rad, Gem/Kir family member 2 (Rgk2) encodes a protein that regulates voltage-gated calcium channel activity." FBgn0085420 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in adult head; embryonic/larval crystal cell; optic lobe intrinsic neurons; and procrystal cell. Orthologous to several human genes including LSAMP (limbic system associated membrane protein). FBgn0085421 FlyBase Gene Snapshot "Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion." FBgn0085422 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. FBgn0085423 Alliance Predicted to enable sterol binding activity and sterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval brain; and embryonic/larval gut. Orthologous to several human genes including GRAMD1C (GRAM domain containing 1C). FBgn0085424 FlyBase Gene Snapshot nubbin (nub) encodes a POU/homeodomain transcription factor that is expressed in the nascent wing primordium and is required for wing formation. FBgn0085425 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. FBgn0085426 FlyBase Gene Snapshot "Rad, Gem/Kir family member 3 (Rgk3) encodes a protein that regulates voltage-gated calcium channel activity." FBgn0085427 Alliance Is expressed in wing disc. FBgn0085428 FlyBase Gene Snapshot NADPH oxidase (Nox) encodes a protein involved in calcium flux and smooth muscle contraction during ovulation. FBgn0085430 UniProtKB "Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO1, thereby exposing miRNAs for degradation (By similarity). (UniProtKB:Q9VWN9)" FBgn0085431 Alliance Enables channel activator activity. Involved in positive regulation of glutamatergic synaptic transmission and presynaptic modulation of chemical synaptic transmission. Located in presynaptic membrane. Is expressed in adult fat body. FBgn0085432 FlyBase Gene Snapshot pangolin (pan) encodes an HMG-domain transcription factor that is a key component of the canonical Wingless signaling pathway. It toggles between acting as a transcriptional repressor (when bound to the product of gro) and activator (when bound to the product of arm) to promote cell fate specification. FBgn0085433 Alliance Predicted to be involved in establishment of protein localization. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). FBgn0085434 FlyBase Gene Snapshot "Na channel protein 60E (NaCP60E) encodes a voltage-gated calcium-selective cation channel that likely modulates the stability of neural circuits, particularly under environmental stresses." FBgn0085436 FlyBase Gene Snapshot Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development. FBgn0085437 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). FBgn0085438 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0085440 FlyBase Gene Snapshot Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) encodes a protein that shows highest similarity with vertebrate receptors for relaxin-like peptides. FBgn0085442 UniProtKB Induces a small but significant sodium conductance when expressed in Xenopus oocytes. (UniProtKB:A6MHQ4) FBgn0085443 UniProtKB "Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP (By similarity). (UniProtKB:Q8MQW8)" FBgn0085444 FlyBase Gene Snapshot muscle wasted (mute) encodes a component of the histone locus body involved in muscle homeostasis. FBgn0085446 Alliance Predicted to be involved in actin cytoskeleton organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in adult head; adult heart; embryonic/larval muscle system; embryonic/larval somatic muscle cell; and spermatozoon. FBgn0085447 FlyBase Gene Snapshot "still life (sif) encodes a guanine nucleotide exchange factor for Rho family GTPases. It is specifically localized to presynaptic terminals in both the central nervous system and neuromuscular junctions (NMJs), and regulates synaptic growth at NMJs." FBgn0085450 FlyBase Gene Snapshot "Sno oncogene (Snoo) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. It specifically binds the product of Med and switches its affinity from the products of Mad to Smox, resulting in antagonism of the product of dpp and facilitation of Activin signaling. Snoo overexpression antagonizes both pathways." FBgn0085451 Alliance "Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coregulator binding activity. Involved in positive regulation of Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of Sin3-type complex. Is expressed in several structures, including adult brain cell body rind; anterior endoderm; anterior endoderm anlage; ganglia; and mesoderm. Orthologous to human ARID4A (AT-rich interaction domain 4A) and ARID4B (AT-rich interaction domain 4B)." FBgn0085452 Alliance Predicted to enable ATPase binding activity and ATPase inhibitor activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1). FBgn0085453 Alliance Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase). FBgn0085454 Alliance Is expressed in spermatozoon. FBgn0085455 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0085456 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0085459 Alliance Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in membrane. FBgn0085464 Alliance Predicted to enable myosin heavy chain binding activity. Involved in sexual reproduction. Located in extracellular space. FBgn0085465 Alliance Predicted to be involved in proteolysis. FBgn0085466 Alliance Predicted to be involved in proteolysis. FBgn0085468 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 12. Orthologous to human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1)." FBgn0085470 FlyBase Gene Snapshot lemming B (lmgB) encodes is part of the dicistronic lemming locus with two open reading frames (ORFs): lmgA (upstream ORF) and lmgB (downstream ORF). The lmgB ORF codes for a putative polypeptide of 365 amino acids that appears to be conserved in Drosophilidae but not in other species. FBgn0085474 Alliance Predicted to enable zinc ion binding activity. Is expressed in adult heart. FBgn0085476 Alliance "Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0085477 Alliance "Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); glucose metabolism disease (multiple); hypotrichosis 7; and obesity. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0085478 UniProtKB Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (By similarity). Regulates tissue growth possibly by regulating Ras64B protein stability (PubMed:30735487). May regulate CG34450 mRNA levels (PubMed:30735487). (UniProtKB:Q9W345) FBgn0085480 Alliance Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in protein glycosylation. FBgn0085481 Alliance Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Is expressed in spermatozoon. FBgn0085483 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region and mitochondrion. FBgn0085484 FlyBase Gene Snapshot "Pyridoxal kinase (Pdxk) encodes the enzyme that generates Pyridoxal-5-phosphate, the metabolically active form of vitamin B6. It contributes to chromosome integrity and glucose homeostasis." FBgn0085485 Alliance Predicted to be located in cytoplasm. FBgn0085486 Alliance Predicted to be involved in cilium assembly. Predicted to be active in motile cilium. Orthologous to human CFAP161 (cilia and flagella associated protein 161). FBgn0085487 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0085489 Alliance Predicted to be located in extracellular space. Is expressed in adult head. FBgn0085491 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. FBgn0085506 Alliance Predicted to enable protein kinase regulator activity. Predicted to be part of protein kinase CK2 complex. FBgn0085512 UniProtKB "Neuropeptides RYamide-1 and RYamide-2 are ligands for the G-protein coupled receptor RYa-R (PubMed:21704020, PubMed:21843505). May suppress feeding behavior (PubMed:21704020). (UniProtKB:G5CKU5)" FBgn0085521 Alliance Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be active in nucleolus. Orthologous to human ABT1 (activator of basal transcription 1). FBgn0085638 Alliance Predicted to enable oxidoreductase activity. Is expressed in adult head. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase). FBgn0085736 Alliance "Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head. Orthologous to human NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2)." FBgn0085693 Alliance Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be active in nucleolus. Orthologous to human ABT1 (activator of basal transcription 1). FBgn0085802 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0086021 FlyBase Gene Snapshot C/D box small nucleolar RNA 59 (snoRNA:CD59) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation in U6 snRNA. FBgn0086023 FlyBase Gene Snapshot C/D box small nucleolar RNA 51a (snoRNA:CD51a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2659 in 28SrRNA:CR45844. FBgn0086024 FlyBase Gene Snapshot C/D box small nucleolar RNA 51b (snoRNA:CD51b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2659 in 28SrRNA:CR45844. FBgn0086025 FlyBase Gene Snapshot C/D box small nucleolar RNA 51c (snoRNA:CD51c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2659 in 28SrRNA:CR45844. FBgn0086027 FlyBase Gene Snapshot C/D box small nucleolar RNA 60 (snoRNA:CD60) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0086028 FlyBase Gene Snapshot C/D box small nucleolar RNA 49 (snoRNA:CD49) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G2243 in 28SrRNA:CR45844. FBgn0086033 FlyBase Gene Snapshot C/D box small nucleolar RNA 50 (snoRNA:CD50) is predicted to encode a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation in rRNA. FBgn0086039 FlyBase Gene Snapshot C/D box small nucleolar RNA 48 (snoRNA:CD48) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2183 in 28SrRNA:CR45844. FBgn0086041 FlyBase Gene Snapshot C/D box small nucleolar RNA 36 (snoRNA:CD36) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A469 in 18SrRNA:CR45838. FBgn0086042 FlyBase Gene Snapshot C/D box small nucleolar RNA 44 (snoRNA:CD44) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1005 in 28SrRNA:CR45844. FBgn0086048 FlyBase Gene Snapshot C/D box small nucleolar RNA 56b (snoRNA:CD56b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U3415 in 28SrRNA:CR45844. FBgn0086049 FlyBase Gene Snapshot C/D box small nucleolar RNA 56a (snoRNA:CD56a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U3415 in 28SrRNA:CR45844. FBgn0086051 FlyBase Gene Snapshot C/D box small nucleolar RNA 30a (snoRNA:CD30a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U2204 in 28SrRNA:CR45844. FBgn0086053 FlyBase Gene Snapshot C/D box small nucleolar RNA 39a (snoRNA:CD39a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1359 in 18SrRNA:CR45838. FBgn0086054 FlyBase Gene Snapshot C/D box small nucleolar RNA 39b (snoRNA:CD39b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G1359 in 18SrRNA:CR45838. FBgn0086055 FlyBase Gene Snapshot C/D box small nucleolar RNA 37 (snoRNA:CD37) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C1096 in 18SrRNA:CR45838. FBgn0086056 FlyBase Gene Snapshot C/D box small nucleolar RNA 23 (snoRNA:CD23) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A425 in 18SrRNA:CR45838. FBgn0086057 FlyBase Gene Snapshot C/D box small nucleolar RNA 47 (snoRNA:CD47) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A3420 in 28SrRNA:CR45844. FBgn0086061 FlyBase Gene Snapshot C/D box small nucleolar RNA 62 (snoRNA:CD62) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C1303 in 18SrRNA:CR45838. FBgn0086062 FlyBase Gene Snapshot C/D box small nucleolar RNA 26b (snoRNA:CD26b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C813 in 28SrRNA:CR45844. FBgn0086063 FlyBase Gene Snapshot C/D box small nucleolar RNA 26a (snoRNA:CD26a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C813 in 28SrRNA:CR45844. FBgn0086064 FlyBase Gene Snapshot C/D box small nucleolar RNA 32b (snoRNA:CD32b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3184 in 28SrRNA:CR45844. FBgn0086065 FlyBase Gene Snapshot C/D box small nucleolar RNA 32a (snoRNA:CD32a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3184 in 28SrRNA:CR45844. FBgn0086066 FlyBase Gene Snapshot C/D box small nucleolar RNA 34 (snoRNA:CD34) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G74 in 5.8SrRNA:CR45852. FBgn0086067 FlyBase Gene Snapshot C/D box small nucleolar RNA 43 (snoRNA:CD43) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A796 and A799 in 28SrRNA:CR45844. FBgn0086068 FlyBase Gene Snapshot C/D box small nucleolar RNA 29 (snoRNA:CD29) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C1679 and A1691 in 28SrRNA:CR45844. FBgn0086069 FlyBase Gene Snapshot C/D box small nucleolar RNA 57 (snoRNA:CD57) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3422 in 28SrRNA:CR45844. FBgn0086070 FlyBase Gene Snapshot C/D box small nucleolar RNA 64c (snoRNA:CD64c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0086071 FlyBase Gene Snapshot C/D box small nucleolar RNA 64b (snoRNA:CD64b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0086072 FlyBase Gene Snapshot C/D box small nucleolar RNA 64a (snoRNA:CD64a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0086074 FlyBase Gene Snapshot C/D box small nucleolar RNA 41 (snoRNA:CD41) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A1806 in 18SrRNA:CR45838. FBgn0086075 FlyBase Gene Snapshot C/D box small nucleolar RNA 55 (snoRNA:CD55) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G3324 and G3326 in 28SrRNA:CR45844. FBgn0086078 FlyBase Gene Snapshot C/D box small nucleolar RNA 25b (snoRNA:CD25b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A799 in 28SrRNA:CR45844. FBgn0086079 FlyBase Gene Snapshot C/D box small nucleolar RNA 25a (snoRNA:CD25a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A799 in 28SrRNA:CR45844. FBgn0086129 FlyBase Gene Snapshot something that sticks like glue (snama) encodes a protein required for cell proliferation and survival in the developing eye. It is involved in apoptosis. FBgn0086130 FlyBase Gene Snapshot "DEAD box protein 21E2 (Dbp21E2) encodes an essential protein and a member of a family of DEAD box RNA helicases. Photoreceptors lacking Dbp21E2 function show defects in rhodopsin biogenesis and the maintenance of photoreceptors, leading to cell degeneration." FBgn0086134 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:P40301)" FBgn0086208 Alliance Involved in regulation of growth. FBgn0086251 FlyBase Gene Snapshot deadlock (del) encodes a protein that interacts with the products of rhi and cuff in a germline complex that allows noncanonical transcription of dual-strand piRNA clusters. It is therefore an integral part of the piRNA response to transposon activity in the germline. FBgn0086253 FlyBase Gene Snapshot "rumi (rumi) encodes an endoplasmic reticulum enzyme that adds a glucose residue to EGF-like repeats with a specific consensus sequence. It modulates the Notch signaling pathway and seems to regulate the function of other proteins, including the product of eys." FBgn0086254 Alliance "Enables aldose reductase (NADPH) activity. Involved in fructose biosynthetic process and sorbitol biosynthetic process. Located in extracellular space. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; follicle cell; and germline cell. Human ortholog(s) of this gene implicated in several diseases, including arteriosclerosis; congenital bile acid synthesis defect 2; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B)." FBgn0086265 FlyBase Gene Snapshot "palisade (psd) encodes a secreted protein required during oogenesis to coordinate assembly and cross-linking of the vitelline membrane layer of the eggshell. It is also one of several targets of the sulfotransferase encoded by pip, which is involved in developmental patterning." FBgn0086266 Alliance Predicted to be a structural constituent of vitelline membrane. Predicted to be involved in vitelline membrane formation involved in chorion-containing eggshell formation. Located in egg chorion. FBgn0086295 Alliance Involved in filopodium assembly. FBgn0086296 Alliance Involved in dendrite morphogenesis. FBgn0086300 Alliance Involved in dendrite morphogenesis and filopodium assembly. FBgn0086301 Alliance Involved in filopodium assembly. FBgn0086302 Alliance Involved in dendrite morphogenesis. FBgn0086303 Alliance Involved in filopodium assembly. FBgn0086305 Alliance Involved in dendrite morphogenesis. FBgn0086346 FlyBase Gene Snapshot "ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis." FBgn0086347 UniProtKB "Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Generates left-right asymmetry at the level of single cells, organs and the whole body via its interaction with the actin cytoskeleton, both in the embryo and the adult (PubMed:16598258, PubMed:16598259, PubMed:18521948, PubMed:25659376, PubMed:26073018, PubMed:30467170). Normal left-right asymmetry of the larval midgut and hindgut requires expression in the embryonic hindgut epithelium during a critical time period, 10 to 12.75 hours after egg laying (PubMed:18521948). This period corresponds to a late stage of germband retraction, and precedes left-right asymmetric morphogenesis (PubMed:18521948). Expression in segment H1 of the imaginal ring is required at 0 to 24 hours after pupation for changes of cell shape and orientation in the H2 segment, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:16598258, PubMed:26073018). Required during a critical period, 126-132 hours after egg laying, for normal, dextral rotation of the adult male genitalia (PubMed:16598258, PubMed:16598259, PubMed:22491943, PubMed:25659376, PubMed:26073018). Has a double role by promoting dextral rotation in the posterior compartment of segment A8 of the male genital disk, and in repressing sinistral looping in the anterior compartment (PubMed:16598259). (UniProtKB:Q23978)" FBgn0086348 FlyBase Gene Snapshot sepia (se) is expressed in the adult eyes and its product is involved in drosopterin synthesis. FBgn0086350 FlyBase Gene Snapshot "teflon (tef) encodes a protein required for the maintenance of pairing between homologs at meiosis I, specifically in males. It is required for the localization of the product of mod(mdg4) to paired autosomal bivalents." FBgn0086355 FlyBase Gene Snapshot "Triose phosphate isomerase (Tpi) encodes a soluble metabolic protein dimer that functions in glycolysis catalyzing the isomerization between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which is essential for efficient ATP production." FBgn0086356 FlyBase Gene Snapshot tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. FBgn0086357 FlyBase Gene Snapshot "Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel." FBgn0086358 FlyBase Gene Snapshot "TAK1-associated binding protein 2 (Tab2) encodes a protein with an ubiquitin binding domain. It interacts with the product of Tak1, a MAP kinase kinase kinase involved the activation of the immune deficiency, JNK and Grindelwald-Eiger pathways." FBgn0086359 FlyBase Gene Snapshot "Invadolysin (Invadolysin) encodes a metalloprotease that is required for mitosis, cell migration and mitochondrial function." FBgn0086361 FlyBase Gene Snapshot alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling. FBgn0086362 FlyBase Gene Snapshot spn-F (spn-F) encodes a coiled-coil protein that forms part of the IKKepsilon-jvl complex. Its roles include actin and microtubule organization during oocyte development and bristle growth. FBgn0086365 FlyBase Gene Snapshot "Organic cation transporter 2 (Orct2) encodes an organic cation transporter of the major facilitator superfamily, and a transcriptional target of the insulin receptor pathway." FBgn0086367 FlyBase Gene Snapshot "tan (t) encodes a hydrolase involved in both the conversion of N-beta-alanyldopamine to dopamine in the cuticle and central nervous system, and the conversion of beta-alanylhistamine (carcinine) to histamine in the retina. It functions in vision, cuticular melanization, and neurotransmitter recycling." FBgn0086368 FlyBase Gene Snapshot "twisted (tw) encodes a protein that transfers a mannose to the Ser/Thr residues of dystroglycan, via forming an heterodimer with the product of rt. Its roles include myogenesis, muscle architecture and cell adhesion." FBgn0086370 UniProtKB "Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte. (UniProtKB:Q9XZL8)" FBgn0086371 FlyBase Gene Snapshot "Elongator complex protein 6 (Elp6) encodes a mediator of the InR/TOR signaling pathway. Its functions include growth regulation, cell survival, cell polarization, and establishment/maintenance of interphase higher-order chromatin structures." FBgn0086372 FlyBase Gene Snapshot like-AP180 (lap) encodes a cytosolic protein that acts as a clathrin adaptor to promote clathrin-coated vesicle formation and restrict coated vesicle size. At synapses it regulates synaptic vesicle size as well as the efficacy of synaptic vesicle protein retrieval. FBgn0086378 Alliance Predicted to enable calcium ion binding activity. Involved in positive regulation of JNK cascade. Is expressed in organism. Orthologous to human PDCD6 (programmed cell death 6). FBgn0086384 FlyBase Gene Snapshot Merlin (Mer) encodes a FERM domain containing protein that promotes assembly of a functional Hippo signaling complex at the apical cell cortex. It has also been associated with cell junctions and endocytic compartments. FBgn0086408 FlyBase Gene Snapshot stall (stl) encodes a protein involved in neuron migration inhibition and ovarian follicle development. FBgn0086442 FlyBase Gene Snapshot mind bomb 2 (mib2) encodes a protein required for regulating synaptic plasticity and memory formation and maintaining muscle integrity. FBgn0086443 Alliance Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; organism; and spermatozoon. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). FBgn0086444 Alliance "Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human DHX16 (DEAH-box helicase 16)." FBgn0086445 Alliance Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be part of transcription factor TFIIIC complex. Is expressed in organism. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). FBgn0086446 Alliance Predicted to enable dynein complex binding activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of dynactin complex. Orthologous to human DCTN6 (dynactin subunit 6). FBgn0086447 UniProtKB "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). (UniProtKB:Q9VIZ0)" FBgn0086448 FlyBase Gene Snapshot "Phosphatidylinositol glycan anchor biosynthesis class Q (PIG-Q) encodes a protein required for the biosynthesis of glycosylphosphatidylinositol, which is a component for anchoring eukaryotic proteins to membranes." FBgn0086450 FlyBase Gene Snapshot "suppressor of rudimentary (su(r)) encodes a dihydropyrimidine dehydrogenase, the first step of pyrimidine catabolism. su(r) depletion does not produce visible phenotypes, but synergistic effects are exhibited by combining mutants with genes affecting pyrimidine biosynthesis and beta-alanine metabolism." FBgn0086451 UniProtKB "Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. (UniProtKB:Q9VM75)" FBgn0086472 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPS25 (ribosomal protein S25). FBgn0086519 UniProtKB Component of the larval cuticle. (UniProtKB:Q7JZV0) FBgn0086532 Alliance "Predicted to enable serine C-palmitoyltransferase activity. Involved in positive regulation of sphingolipid biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; embryonic/larval midgut primordium; and gut section. Used to study hereditary sensory and autonomic neuropathy type 1; hereditary sensory and autonomic neuropathy type 1A; and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A and juvenile amyotrophic lateral sclerosis type 27. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1)." FBgn0086533 FlyBase Gene Snapshot C/D box small nucleolar RNA 35 (snoRNA:CD35) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C419 in 18SrRNA:CR45838. FBgn0086558 Alliance Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in polytene chromosome band. Is expressed in organism and testis. FBgn0086601 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0086603 FlyBase Gene Snapshot C/D box small nucleolar RNA 20 (snoRNA:CD20) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of pU2692 in 28SrRNA:CR45844. FBgn0086604 Alliance Is expressed in adult head; lineage NB3-1 primary motor neurons; and pCC neuron. FBgn0086605 UniProtKB May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane. (UniProtKB:Q9VN19) FBgn0086611 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. FBgn0086655 UniProtKB "May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary. (UniProtKB:Q7KHG2)" FBgn0086656 FlyBase Gene Snapshot "shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling." FBgn0086657 FlyBase Gene Snapshot "I-kappaB kinase epsilon (IKKepsilon) encodes a serine-threonine kinase that targets the inhibitor of apoptosis encoded by Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor encoded nuf. The product of IKKepsilon contributes to the specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development." FBgn0086665 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0086669 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0086671 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0086674 UniProtKB Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (By similarity). Has a role in protein secretion. (UniProtKB:Q9VYB7) FBgn0086675 FlyBase Gene Snapshot found in neurons (fne) encodes an RNA binding protein that works as a post-transcriptional regulator. It is present in the cytoplasm of all neurons. Lack of fne produces fusion of the mushroom body beta-lobes and altered male courtship behaviour. FBgn0086676 FlyBase Gene Snapshot spinster (spin) encodes a conserved transmembrane protein and a putative late-endosomal/lysosomal efflux permease. It is essential for mTOR reactivation and lysosome reformation following prolonged starvation and for regulation of TGF-beta/BMP pathways in motoneuron and eye development. FBgn0086677 FlyBase Gene Snapshot "jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning." FBgn0086679 UniProtKB Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes. (UniProtKB:Q9VHN9) FBgn0086680 FlyBase Gene Snapshot "ventral veins lacking (vvl) encodes a transcription factor that acts together with other transcription factors in a context-dependent manner. Roles for this transcription factor include specification of cell fates, patterning and immune defense." FBgn0086681 Alliance Involved in spermatogenesis. Is expressed in primary spermatocyte; spermatid; and spermatocyte. FBgn0086683 FlyBase Gene Snapshot Spf45 (Spf45) encodes a bi-functional protein with roles in both splicing and DNA repair. FBgn0085407 FlyBase Gene Snapshot "PDGF- and VEGF-related factor 3 (Pvf3) encodes a ligand for the receptor tyrosine kinase encoded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells." FBgn0086686 Alliance Involved in gravitaxis. Predicted to be active in nucleus. Is expressed in organism; wing hinge primordium; and wing pouch. Orthologous to human INO80D (INO80 complex subunit D). FBgn0086687 FlyBase Gene Snapshot Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C14:0 and C18:0) to synthesize myristoleic and oleic acids (C14:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids. FBgn0086690 FlyBase Gene Snapshot Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. FBgn0086691 UniProtKB "Molecular chaperone. Seems to fulfill an ATP-independent, HSP70-like function in protein folding. May protect essential factors of cell proliferation during heat shock. No role in calpain activation. (UniProtKB:Q9V3W0)" FBgn0086693 FlyBase Gene Snapshot "inactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound." FBgn0086694 FlyBase Gene Snapshot Bre1 (Bre1) encodes an E3 ubiquitin ligase that interacts with the E2 ubiquitin ligase encoded by Ubc6 to direct ubiquitination of histone H2B on lysine 120 at most RNA Polymerase II transcribed genes. It regulates Notch signaling. FBgn0086695 FlyBase Gene Snapshot "humpty dumpty (hd) encodes a protein required for genomic DNA replication and developmental gene amplification. It localizes to subnuclear speckles, the nuclear envelope, and cytoplasmic bodies." FBgn0086698 FlyBase Gene Snapshot fritz (frtz) encodes a cytoplasmic protein that functions as a planar polarity effector as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity. frtz protein directly binds to the product of in and accumulates on the proximal side of wing cells. FBgn0086704 Alliance Involved in negative regulation of opsin-mediated signaling pathway and sensory perception of sound. Orthologous to human ASB17 (ankyrin repeat and SOCS box containing 17). FBgn0086706 FlyBase Gene Snapshot "pixie (pix) encodes ABCE1, which is an ATPase that functions as a translation recycling factor. It is required for the assembly of complexes involved in translation initiation, and plays a role in the regulation of cellular and organismal growth." FBgn0086707 FlyBase Gene Snapshot "nucampholin (ncm) encodes a protein that is predicted to be an essential component of the spliceosome, implicated in regulation of pre-mRNA splicing and assembly of the exon junction complex." FBgn0086708 FlyBase Gene Snapshot "starvin (stv) encodes a BAG family member that binds heat shock proteins. It plays roles in somatic muscles and is involved in the chaperone pathway essential for muscle maintenance. It also acts as co-chaperone of Hsp70 proteins during recovery from stress, including cold stress." FBgn0086710 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; larval optic neuroblast; medulla; and organism. Human ortholog(s) of this gene implicated in herpes simplex. Orthologous to human RPL30 (ribosomal protein L30). FBgn0086711 Alliance Involved in long-term memory; protein localization; and response to oxidative stress. Located in basal part of cell and plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to several human genes including DUOXA1 (dual oxidase maturation factor 1). FBgn0086712 FlyBase Gene Snapshot Enigma (Egm) encodes a mitochondrial oxidoreductase involved in oxidative stress response and lipid homeostasis. FBgn0086757 FlyBase Gene Snapshot Golgin 97 (Golgin97) encodes a a Golgi protein required for the centrosome cycle. FBgn0086758 FlyBase Gene Snapshot "Chronologically inappropriate morphogenesis (chinmo) encodes a putative BTB-zinc finger transcription factor. It is essential for neuronal temporal patterning. It also plays a role in the regulation of eye development, tumor formation, and the self-renewal and/or sexual identity of male somatic cyst stem cells by acting downstream of JAK-STAT signaling." FBgn0086768 UniProtKB Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. (UniProtKB:Q27869) FBgn0086778 FlyBase Gene Snapshot "nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel." FBgn0086779 FlyBase Gene Snapshot "steppke (step) encodes a member of the cytohesin family of guanine nucleotide exchange factors, which regulate small GTPases of the ADP-ribosylation factor (ARF) family. It contributes to multiple signaling pathways, such as Egfr, MAPK, PI3K and insulin signaling. It is involved in wing and eye development, germ cell segregation and cell growth." FBgn0086782 FlyBase Gene Snapshot "amnesiac (amn) encodes an apparent pre-pro-neuropeptide that functions to prolong medium-term memory. In the adult, it is almost entirely concentrated in two large neurosecretory cells (Dorsal Paired Median cells)." FBgn0086784 UniProtKB An essential gene required for embryogenesis; required for cell viability. (UniProtKB:Q8IGJ0) FBgn0086785 FlyBase Gene Snapshot "Vacuolar protein sorting 36 (Vps36) encodes a component of the ESCRT-II complex. It interacts with the product of Vps28 (a component of the ESCRT-I complex), endosomal lipid PtdIns(3)P and Ubiquitin." FBgn0086856 Alliance "Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; germline cell; and mesoderm." FBgn0086895 UniProtKB "Involved in pre-mRNA splicing as component of the spliceosome (PubMed:18981222, PubMed:24244416). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (By similarity). Before and after egg-chamber formation, required for nurse-cell chromatin dispersal (NCCD) probably by playing a role in spliceosome localization to chromatin/interchromatin spaces (PubMed:24244416). (UniProtKB:A1Z9L3)" FBgn0086898 FlyBase Gene Snapshot diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. FBgn0086900 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Is expressed in organism. FBgn0086904 UniProtKB May promote appropriate targeting of ribosome-nascent polypeptide complexes (By similarity). Required for correct localization of the osk/oskar protein to the posterior pole during embryonic development. The osk protein directs the recruitment of molecules responsible for posterior body patterning and germline formation in the embryo. (UniProtKB:Q94518) FBgn0086906 FlyBase Gene Snapshot sallimus (sls) encodes a large modular protein present in muscles. It links myosin filaments to the Z-disc. FBgn0086907 UniProtKB "Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (UniProtKB:P04657)" FBgn0086908 FlyBase Gene Snapshot "eggless (egg) encodes a histone methyltransferase involved in epigenetic regulation of gene expression. It contributes to stem cell asymmetric division, oogenesis and wing disc development." FBgn0086909 Alliance Predicted to enable hydroxylysine kinase activity. Is expressed in adult head. Orthologous to human HYKK (hydroxylysine kinase). FBgn0086912 FlyBase Gene Snapshot mushroom body miniature (mbm) encodes a zinc finger containing protein that localizes in the nucleolus. It plays a role in ribosome biogenesis. FBgn0086913 UniProtKB Participates in exocrine secretion. (UniProtKB:Q9VP48) FBgn0086915 FlyBase Gene Snapshot Male-specific transcript 77F (Mst77F) encodes a sperm component. FBgn0086916 FlyBase Gene Snapshot sneaky (snky) encodes a sperm-specific transmembrane protein found in the acrosomal membrane. It is critically required for sperm plasma membrane breakdown at fertilization. FBgn0086917 FlyBase Gene Snapshot "spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway." FBgn0087002 FlyBase Gene Snapshot "apolipophorin (apolpp) encodes an apolipoprotein of the ApoB family. It is complexed with lipids to assemble the major hemolymph lipoprotein, lipophorin. Lipophorin transports neutral lipids, phospholipids and sterols between tissues. Lipophorin also carries lipophilic hormones and signaling molecules." FBgn0087003 FlyBase Gene Snapshot "tarsal-less (tal) is a polycistronic transcription unit with 4 non-overlapping reading frames (tal-1A, tal-2A, tal-3A and tal-AA), which encode four peptides. Tal peptides control the post-transcriptional activation of ovo, which in turn regulates Notch signalling and F-actin organization." FBgn0087005 UniProtKB Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma (PubMed:22496551). Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554). (UniProtKB:Q9VN91) FBgn0087007 Alliance "Involved in border follicle cell migration and imaginal disc-derived wing morphogenesis. Located in apical part of cell; nucleus; and septate junction. Is expressed in several structures, including anlage in statu nascendi; epithelium; follicle cell; gut section; and sensory organ cell. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human PDZD2 (PDZ domain containing 2) and IL16 (interleukin 16)." FBgn0087008 FlyBase Gene Snapshot enhancer of yellow 3 (e(y)3) encodes a nuclear protein required for embryogenesis and oogenesis. It participates in gene activation in euchromatin as a component of both the SWI/SNF chromatin remodeling complex and the TFIID transcription coactivator. It also contributes to gene silencing in pericentric heterochromatin and is also a coactivator in the JAK/STAT pathway. FBgn0087011 Alliance Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in embryonic epipharynx; embryonic hypopharynx; embryonic ventral epidermis; and embryonic/larval posterior spiracle. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; hereditary angioedema; hereditary lymphedema; and hypertension. Orthologous to several human genes including ANGPT1 (angiopoietin 1) and ANGPT2 (angiopoietin 2). FBgn0087012 FlyBase Gene Snapshot "5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7." FBgn0087013 Alliance Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Located in cytosol. Is expressed in adult head and adult heart. Orthologous to human RANBP6 (RAN binding protein 6) and IPO5 (importin 5). FBgn0087021 FlyBase Gene Snapshot "Spc25 (Spc25) encodes a component of the Ndc80 complex, which is an essential kinetochore constituent." FBgn0087035 FlyBase Gene Snapshot "Argonaute 2 (AGO2) encodes an Argonaute/Piwi family protein, which interacts with small interfering RNAs (siRNAs) to form RNA-induced silencing complexes (RISCs). RISCs are guided to target and cleave transcripts (mostly from transposons and viruses)." FBgn0087039 FlyBase Gene Snapshot SECIS-binding protein 2 (Sbp2) encodes an RNA stem-loop binding protein involved in selenocysteine incorporation at a stop codon (UGA) during translation. FBgn0087040 FlyBase Gene Snapshot alpha-Tubulin at 67C (alphaTub67C) encodes a protein that form heterodimers with beta-tubulins to polymerise and form microtubules. Tubulin molecules containing the product of alphaTub67C are essential for fast growth of the microtubules during the initial cleavage divisions of embryogenesis. FBgn0087041 Alliance Predicted to be involved in cilium assembly. Located in centriole and ciliary basal body. Human ortholog(s) of this gene implicated in hydrolethalus syndrome 1. Orthologous to human HYLS1 (HYLS1 centriolar and ciliogenesis associated). FBgn0243486 FlyBase Gene Snapshot reduced ocelli (rdo) encodes a transmembrane leucine rich repeat protein involved in ocelli development. FBgn0243511 UniProtKB "Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval immune response: required both for the phagocytic degradation of internalized bacteria and for the induction of Defensin in the fat body. Within the phagocytic blood cells, has a role in detection of infection and activation of the humoral immune response. (UniProtKB:Q9VDQ7)" FBgn0243512 FlyBase Gene Snapshot puckered (puc) encodes a serine/threonine protein phosphatase that mediates a feedback loop that regulates the Jun-N-terminal kinase pathway. FBgn0243513 Alliance Involved in vesicle-mediated transport. Predicted to be active in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human CNIH4 (cornichon family member 4). FBgn0243514 FlyBase Gene Snapshot eater (eater) encodes a transmembrane receptor of the Nimrod family specifically expressed in hemocytes and required for the phagocytosis of Gram positive bacteria and the attachment of hemocytes to sessile niches. FBgn0243516 FlyBase Gene Snapshot Verprolin 1 (Vrp1) encodes the sole Drosophila homolog of the conserved Verprolin/WASp-interacting-protein family of actin regulators. It facilitates myoblast fusion in somatic muscles by recruiting the branched-actin polymerization machinery to sites of myoblast-myotube attachment and fusion. FBgn0243586 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in dorsal head epidermis; embryonic dorsal epidermis; embryonic ventral epidermis; lateral head epidermis; and ventral head epidermis. FBgn0250731 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0250732 FlyBase Gene Snapshot GST-containing FLYWCH zinc-finger protein (gfzf) encodes encodes a glutathione binding protein that is predicted by phylogeny to have glutathione transferase activity. FBgn0250746 UniProtKB "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (UniProtKB:Q9VNA5)" FBgn0250753 FlyBase Gene Snapshot "krasavietz (kra) encodes a translational regulator that is able to interact with the translation initiation factor encoded by eIF2beta. It is involved in axon guidance, long-term memory, and alcohol addiction." FBgn0250754 Alliance "Is expressed in several structures, including anterior endoderm; ganglia; germline cell; mesoderm; and neuroblasts." FBgn0250755 Alliance Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human DCAF5 (DDB1 and CUL4 associated factor 5). FBgn0250757 Alliance Enables solute:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). FBgn0250785 FlyBase Gene Snapshot varicose (vari) encodes a protein involved in tracheal system development and septate junction assembly. FBgn0250786 FlyBase Gene Snapshot "Chromodomain-helicase-DNA-binding protein 1 (Chd1) encodes an ATPase involved in the remodeling and assembly of chromatin. Its biological functions include regulation of gene transcription, incorporation of the histone variant H3.3 into paternal chromatin at fertilization and regulation of intestinal immunity and microbiota." FBgn0250788 FlyBase Gene Snapshot beta Spectrin (beta-Spec) encodes an essential protein that interacts with the product of alpha-Spec to form a heterotetramer. The product of beta-Spec is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. FBgn0250789 FlyBase Gene Snapshot alpha Spectrin (alpha-Spec) encodes an essential protein that interacts with the products of beta-Spec or kst to form a heterotetramer. It is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. FBgn0250791 UniProtKB Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Also between the endosome and phagosome. (UniProtKB:Q23983) FBgn0250814 Alliance "Predicted to enable metal ion binding activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2)." FBgn0250815 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head; cuboidal/columnar epithelium; gastric caecum; and gut section. FBgn0250816 FlyBase Gene Snapshot "Argonaute 3 (AGO3) encodes a germline-specific Argonaute/Piwi family protein, which interacts with Piwi-interacting RNAs (piRNAs) to form effector complexes. It exhibits piRNA-guided RNA cleavage activity required for both piRNA amplification and transposon silencing, thereby securing germline development." FBgn0250819 Alliance Predicted to be involved in actin cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in embryonic/larval muscle system and embryonic/larval somatic muscle cell. FBgn0250820 FlyBase Gene Snapshot "medial glomeruli (meigo) encodes an evolutionarily conserved, multi-membrane pass protein that is mainly localized at the endoplasmic reticulum. meigo genetically interacts with Ephrin in dendrite targeting of olfactory projection neurons." FBgn0250821 Alliance Predicted to be active in plasma membrane. FBgn0250823 FlyBase Gene Snapshot gilgamesh (gish) encodes a plasma membrane-associated kinase that regulates Hedgehog and Wingless signaling activity. It is involved in planar cell polarity via regulation of Rab11-mediated vesicle trafficking FBgn0250827 Alliance Is expressed in elongation stage spermatid; primary spermatocyte; spermatid; and testis. FBgn0250830 Alliance Is expressed in adult head and organism. Orthologous to human NHLRC2 (NHL repeat containing 2). FBgn0250831 FlyBase Gene Snapshot BG642167 (BG642167) encodes a peptide produced by the male accessory glands and is predicted to be secreted. FBgn0250832 UniProtKB Induces post-mating responses; increased oviposition and reduced receptivity. (UniProtKB:P81160) FBgn0250833 Alliance Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in adult head. FBgn0250835 Alliance Is expressed in adult head. FBgn0250836 Alliance "Predicted to enable long-chain fatty acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Orthologous to human ACBD7 (acyl-CoA binding domain containing 7) and DBI (diazepam binding inhibitor, acyl-CoA binding protein)." FBgn0250837 Alliance "Enables dUTP diphosphatase activity. Involved in dUTP metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including CNS glial cell; amnioserosa; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human DUT (deoxyuridine triphosphatase)." FBgn0250838 Alliance Involved in rhodopsin biosynthetic process. Is expressed in adult head and adult heart. Used to study retinal degeneration. FBgn0250839 Alliance "Predicted to be active in extracellular space. Is expressed in several structures, including embryonic head epidermis; embryonic hypopharynx; embryonic salivary gland duct; epithelium; and gut section." FBgn0250841 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and adult heart. FBgn0250842 FlyBase Gene Snapshot "CG17575 encodes a cysteine-rich secretory protein produced in the male accessory glands and transferred to females during mating. In mated females, it is required for the binding of the product of SP to sperm and for the consequent maintenance of long-term post-mating responses." FBgn0250843 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:P12881)" FBgn0250846 Alliance Predicted to enable heme binding activity and oxygen binding activity. Predicted to be located in nucleus. Is expressed in early elongation stage spermatid; onion stage spermatid; organism; primary spermatocyte; and secondary spermatocyte. FBgn0250847 Alliance "Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0250848 Alliance Enables cysteine-type peptidase activity. Involved in Toll receptor ligand protein activation cascade and zymogen activation. Is active in extracellular space. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. FBgn0250850 FlyBase Gene Snapshot rigor mortis (rig) encodes a component of the cytoplasmic U snRNP body and a member of the SMN-Gemins complex. It is required in the motor system for viability and motor behaviour. It also works as a nuclear receptor interacting protein required for ecdysone signalling during larval development. FBgn0250851 Alliance Predicted to be involved in protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Is expressed in organism. Orthologous to human ANAPC13 (anaphase promoting complex subunit 13). FBgn0250862 Alliance Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Is expressed in adult head and organism. Orthologous to human PROCA1 (protein interacting with cyclin A1). FBgn0250868 Alliance Is expressed in organism. FBgn0250871 FlyBase Gene Snapshot "papillote (pot) encodes a transmembrane protein that is part of the apical extracellular matrix, or cuticle. It is needed for the linkage between epithelia and cuticle as well as microtubule organization in epithelial cells." FBgn0250874 FlyBase Gene Snapshot tiny tim 50 (ttm50) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. It plays active roles in regulating metabolic levels for modulation of growth in development. FBgn0250903 FlyBase Gene Snapshot "lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by mr, it forms the minimal ubiquitin ligase module of the APC/C." FBgn0250906 FlyBase Gene Snapshot "Phosphoglycerate kinase (Pgk) encodes an enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate producing ATP. It is involved in glycolysis and while the reverse reaction is involved in gluconeogenesis." FBgn0250907 Alliance "Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be active in extracellular region. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; gut section; and primary segmental tracheal branch primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic)." FBgn0250908 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Is expressed in adult head. FBgn0250910 UniProtKB "Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909). (UniProtKB:Q4LBB6)" FBgn0250911 Alliance Orthologous to human KIAA1143 (KIAA1143). FBgn0259099 UniProtKB "May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. (UniProtKB:Q9VUI3)" FBgn0259101 Alliance Enables ADP phosphatase activity and ATP hydrolysis activity. Predicted to be involved in AMP catabolic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). FBgn0259103 Alliance Involved in positive regulation of dendrite morphogenesis. FBgn0259104 Alliance Involved in positive regulation of dendrite morphogenesis. FBgn0259105 Alliance Involved in positive regulation of dendrite morphogenesis. FBgn0259106 Alliance Involved in positive regulation of dendrite morphogenesis. FBgn0259108 FlyBase Gene Snapshot futsch (futsch) encodes a microtubule binding protein involved in the formation of synaptic buttons at the neuromuscular junctions. Its expression levels are regulated by the product of TBPH to prevent synaptic defects. FBgn0259110 Alliance Predicted to be located in membrane. Is expressed in adult head; dorsal head epidermis; embryonic brain; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to several human genes including ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23). FBgn0259111 FlyBase Gene Snapshot "Na[+]-driven anion exchanger 1 (Ndae1) encodes an intrinsic membrane protein that reversibly mediates the exchange of 1 Na[+] and 2 HCO[[3]][-] for 1 Cl[-] at basolateral membranes of gut and renal epithelia as well as CNS neurons. In the CNS, the product of Ndae1 can lower resting intracellular Cl[-] controlling GABA(A) Cl-channel activity." FBgn0259113 FlyBase Gene Snapshot "DNA polymerase alpha subunit 1 (PolA1) encodes the catalytic subunit of DNA polymerase alpha, responsible for initial synthesis on the leading strand and on each Okazaki fragment of the lagging strand." FBgn0259139 FlyBase Gene Snapshot "glorund (glo) encodes a hnRNP F/H family RNA-binding protein that binds directly to nanos mRNA and regulates its translation during late stages of oogenesis. The functions of the product of glo include nurse cell nuclear chromatin organization, axis patterning as well as being required for viability to adulthood." FBgn0259140 Alliance "Enables cargo receptor activity. Involved in renal protein absorption. Located in cytosol. Part of receptor complex. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; embryonic/larval garland cell; and garland cell primordium. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin)." FBgn0259143 Alliance Located in plasma membrane. Is expressed in adult brain; adult brain cell body rind; and adult head. FBgn0259145 FlyBase Gene Snapshot CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl. FBgn0259146 FlyBase Gene Snapshot fire dancer (fid) encodes a protein involved in heat resistance. FBgn0259149 Alliance Predicted to enable zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0259150 UniProtKB Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. (UniProtKB:B7Z0W9) FBgn0259152 UniProtKB "Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (By similarity). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (By similarity). Within the RQC complex, Clbn/NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety (PubMed:31378462). Following binding to stalled 60S ribosomal subunits, Clbn/NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (By similarity). On mitochondrial surface, plays a role in mitochondrial-stress induced translational termination impairment and protein carboxyl terminal extension (MISTERMINATE) (PubMed:31378462). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins (PubMed:16103875). Plays a role in the regulation of G1-to-S cell cycle transition (PubMed:30231800). Regulates S phase checkpoint by antagonizing E2F1 activity (PubMed:30231800). Together with hid and tefu/ATM, plays a role in DNA damage-induced apoptosis through both p53-dependent and -independent activity (PubMed:22964637). Plays an essential role in the regulation of mitochondrial structure and redox state in enterocytes which is essential for the control of intestinal stem cells proliferation and intestinal homeostasis (PubMed:33057338). (UniProtKB:Q9VBX1)" FBgn0259162 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3)." FBgn0259163 Alliance "Is expressed in several structures, including clypeo-labral primordium; embryonic dorsal epidermis; embryonic epipharynx; ganglia; and gut section." FBgn0259164 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to several human genes including SLC22A1 (solute carrier family 22 member 1); SLC22A2 (solute carrier family 22 member 2); and SLC22A23 (solute carrier family 22 member 23). FBgn0259166 Alliance "Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be active in cytoplasm. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A) and INPP4B (inositol polyphosphate-4-phosphatase type II B)." FBgn0259168 FlyBase Gene Snapshot "minibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth." FBgn0259170 UniProtKB "Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). (UniProtKB:P53624)" FBgn0259171 FlyBase Gene Snapshot Phosphodiesterase 9 (Pde9) encodes a putative phosphodiesterase expressed in Malpighian tubules and involved in neurogenesis. FBgn0259173 FlyBase Gene Snapshot cornetto (corn) encodes a microtubule binding protein involved in exocytosis regulation. FBgn0259174 FlyBase Gene Snapshot "Nedd4 (Nedd4) encodes an E3 ubiquitin ligase that negatively regulates the Notch signaling pathway and the genes comm, Amph. It contributes to neuromuscular synaptogenesis, transverse tubule formation in muscles, and in muscle function." FBgn0259175 FlyBase Gene Snapshot omega (ome) encodes a dipeptidyl-peptidase. FBgn0259176 UniProtKB "Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages. (UniProtKB:Q24523)" FBgn0259178 Alliance Enables inositol-polyphosphate 5-phosphatase activity. Involved in phosphatidylinositol metabolic process. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). FBgn0259184 Alliance Predicted to be located in membrane. FBgn0259185 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in chemosensory neuron of adult labral sensillum 7; gustatory receptor neuron of the epiphysis; gustatory receptor neuron of the hypophysis; and labral sense organ neurons. FBgn0259186 Alliance Is expressed in external sensory organ; gustatory receptor neurons; labral sense organ neurons; larval gnathal ganglion; and wing. FBgn0259187 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis; labellar taste bristle; and labral sense organ neurons. FBgn0259188 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of the epiphysis. FBgn0259189 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of terminal organ and terminal organ. FBgn0259190 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in gustatory receptor neuron of terminal organ; larval abdomen; and terminal organ. FBgn0259192 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0259193 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in larval abdomen. FBgn0259194 Alliance "Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in several structures, including adult subesophageal zone; gustatory receptor neurons; labellar taste bristle; terminal organ; and wing." FBgn0259195 Alliance "Predicted to enable SUMO ligase activity. Predicted to be involved in double-strand break repair via homologous recombination and protein sumoylation. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)." FBgn0259196 Alliance "Predicted to enable SUMO ligase activity. Predicted to be involved in double-strand break repair via homologous recombination and protein sumoylation. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)." FBgn0259198 Alliance Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be part of mitochondrial intermembrane space protein transporter complex. FBgn0259199 FlyBase Gene Snapshot "Snurportin (Snup) encodes a transport adaptor protein that functions together with the product of msk to carry out nuclear import of small nuclear RNPs. It binds specifically to the 2,2,7-trimethylguanosine cap structure that is present on mature snRNAs. Snup is an essential gene, and the protein shuttles between the cytoplasm and the nucleus." FBgn0259200 Alliance Predicted to enable DNA binding activity and nucleosome binding activity. Predicted to be active in nucleus. Orthologous to human DNTTIP1 (deoxynucleotidyltransferase terminal interacting protein 1). FBgn0259201 Alliance Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. FBgn0259202 Alliance Is expressed in organism. FBgn0259203 Alliance Is expressed in adult head. FBgn0259204 UniProtKB "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. (UniProtKB:B7Z0X7)" FBgn0259209 FlyBase Gene Snapshot "Muscle LIM protein at 60A (Mlp60A) encodes a Zinc-ion binding protein, expressed strongly in the Z-band region of the sarcomere. It is involved in development and maintenance of the embryonic and flight muscles." FBgn0259210 FlyBase Gene Snapshot prominin (prom) encodes an evolutionary conserved five transmembrane protein required for the correct positioning and formation of photoreceptor rhabdomeres. FBgn0259211 FlyBase Gene Snapshot "grainy head (grh) encodes the founding member of a highly conserved family of transcription factors essential for embryonic development. It is both a transcriptional activator and repressor, responsible for the proper expression of many genes primarily involved in epithelial cell fate, barrier formation, wound healing, tube morphogenesis and proliferation of larval neuroblasts." FBgn0259212 FlyBase Gene Snapshot canoe (cno) encodes a scaffold protein in adherens junctions that is involved in morphogenesis in a variety of tissues. FBgn0259213 Alliance Is expressed in adult head; embryonic/larval central nervous system; and embryonic/larval muscle system. FBgn0259214 FlyBase Gene Snapshot "plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx." FBgn0259215 UniProtKB "Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27161501, PubMed:27656904). Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27161501, PubMed:27656904). (UniProtKB:Q9VDH6)" FBgn0259216 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Orthologous to human ARHGAP36 (Rho GTPase activating protein 36) and ARHGAP6 (Rho GTPase activating protein 6). FBgn0259219 Alliance Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in dorsal head epidermis; dorsal pharyngeal muscle cell; embryonic brain; embryonic/larval muscle system; and embryonic/larval somatic muscle cell. Orthologous to human PDLIM2 (PDZ and LIM domain 2). FBgn0259221 Alliance "Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including adult head; dorsal sensory complex proper primordium; embryonic hindgut; embryonic large intestine; and ganglia. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to several human genes including ATP8A2 (ATPase phospholipid transporting 8A2)." FBgn0259222 Alliance Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in nucleotide-sugar transmembrane transport. Is expressed in adult head. Orthologous to human SLC35F3 (solute carrier family 35 member F3) and SLC35F4 (solute carrier family 35 member F4). FBgn0259223 Alliance Is expressed in adult head. FBgn0259224 Alliance Orthologous to human BEGAIN (brain enriched guanylate kinase associated) and TJAP1 (tight junction associated protein 1). FBgn0259226 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0259227 Alliance "Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Predicted to be involved in motor neuron axon guidance. Is expressed in several structures, including adult head; embryonic/larval epidermis; embryonic/larval fat body; embryonic/larval peripheral nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K); PTPRM (protein tyrosine phosphatase receptor type M); and PTPRT (protein tyrosine phosphatase receptor type T)." FBgn0259228 FlyBase Gene Snapshot C3G guanyl-nucleotide exchange factor (C3G) is expressed in the developing embryonic muscles and its product plays a role in body wall muscle development during larval stages. FBgn0259229 Alliance "Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Is expressed in adult fat body." FBgn0259230 Alliance "Predicted to enable galactose binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human COLEC11 (collectin subfamily member 11) and MBL2 (mannose binding lectin 2)." FBgn0259231 FlyBase Gene Snapshot Cholecystokinin-like receptor at 17D1 (CCKLR-17D1) encodes a neuropeptide receptor involved in locomotion and neuromuscular junction growth. FBgn0259233 Alliance "Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic esophagus; embryonic head epidermis; and embryonic hypopharynx." FBgn0259236 Alliance Predicted to be involved in axon guidance. FBgn0259237 Alliance Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. FBgn0259238 Alliance Is expressed in adult head; adult heart; anterior endoderm; embryonic/larval midgut; and embryonic/larval midgut primordium. FBgn0259241 Alliance Orthologous to human SBSPON (somatomedin B and thrombospondin type 1 domain containing). FBgn0259242 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in organism. FBgn0259243 FlyBase Gene Snapshot "Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol." FBgn0259244 Alliance "Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including adult brain cell body rind; anlage in statu nascendi; epidermis; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 19. Orthologous to human COL13A1 (collagen type XIII alpha 1 chain)." FBgn0259245 Alliance "Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including CNS glial cell; embryonic/larval nervous system; ganglia; medulla layer; and optic lobe intrinsic columnar neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin)." FBgn0259246 FlyBase Gene Snapshot "bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation." FBgn0259481 FlyBase Gene Snapshot Mob2 (Mob2) encodes a protein that belongs to the Mob1/phocein domain protein family. Its functions include rhabdomere determination during photoreceptor development. FBgn0259482 Alliance Predicted to enable protein kinase activator activity and protein kinase binding activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Orthologous to human MOB3A (MOB kinase activator 3A); MOB3B (MOB kinase activator 3B); and MOB3C (MOB kinase activator 3C). FBgn0259483 FlyBase Gene Snapshot "MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling." FBgn0259676 FlyBase Gene Snapshot "DNA primase subunit 2 (Prim2) encodes a regulatory subunit of the DNA polymerase alpha-primase complex, which synthesizes short RNA-DNA primers on the lagging strand during DNA synthesis." FBgn0259677 Alliance "Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; and primary immunodeficiency disease (multiple). Orthologous to several human genes including IGFALS (insulin like growth factor binding protein acid labile subunit); NRROS (negative regulator of reactive oxygen species); and TLR3 (toll like receptor 3)." FBgn0259678 FlyBase Gene Snapshot spaghetti-squash activator (sqa) encodes a myosin light chain kinase-like protein. It is a substrate of the kinase encoded by Atg1 and is required for starvation-induced autophagy. FBgn0259682 FlyBase Gene Snapshot "Jabba (Jabba) encodes a lipid droplet protein that sequesters histones on lipid droplets. It promotes proper development of pre-cellular embryos, controls levels of nuclear histones, and mediates anti-bacterial protection." FBgn0259683 UniProtKB "Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the hygrosensory sacculus neurons to changes in relative humidity and is required for dry detection behavior (PubMed:27161501, PubMed:27656904). (UniProtKB:Q9V9N1)" FBgn0259685 FlyBase Gene Snapshot "crumbs (crb) encodes a transmembrane protein that binds to multiple proteins such as those encoded by sdt, par-6, AP-2alpha, yrt, ex and Moe. It contributes to organization of zonula adherens, epithelial morphogenesis, apico-basal cell polarity, and is a negative regulator of Notch activity and growth control via the Hippo pathway. In photoreceptor cells it is involved in morphogenesis, the trafficking of the product of ninaE and prevention of light-dependent photoreceptor degeneration." FBgn0259699 Alliance Is expressed in adult head and adult heart. FBgn0259700 Alliance Is expressed in adult head. FBgn0259701 Alliance Predicted to be involved in sperm DNA condensation. FBgn0259702 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0259703 Alliance Predicted to enable ligand-gated channel activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. FBgn0259704 FlyBase Gene Snapshot Nop2/Sun-like domain containing protein 5 (Nsun5) encodes a protein predicted to catalyze the m5C-methylation of 28S ribosomal RNA. Nsun5 loss leads to increased lifespan and heat shock resistance. FBgn0259705 Alliance Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in X-linked myopathy with excessive autophagy. Orthologous to human VMA21 (vacuolar ATPase assembly factor VMA21). FBgn0259711 Alliance Is expressed in organism. FBgn0259712 Alliance Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cilium assembly; intracellular signal transduction; and intraciliary transport. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome; juvenile myoclonic epilepsy 10; and retinitis pigmentosa 62. Orthologous to several human genes including MAK (male germ cell associated kinase). FBgn0259713 Alliance Predicted to be active in extracellular matrix. Is expressed in adult head. FBgn0259714 Alliance "Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including CNS surface glial cell; adult head; glomerulus; optic lobe intrinsic neurons; and presumptive arista. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin)." FBgn0259716 Alliance Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). FBgn0259717 Alliance Orthologous to human CEBPZOS (CEBPZ opposite strand). FBgn0259720 Alliance Predicted to be involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of SOSS complex. Predicted to be active in nucleoplasm. Is expressed in embryonic hindgut; embryonic/larval midgut; and organism. Orthologous to human INIP (INTS3 and NABP interacting protein). FBgn0259721 Alliance Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human CMC2 (C-X9-C motif containing 2). FBgn0259722 Alliance Predicted to be involved in mitochondrial ATP synthesis coupled electron transport and respiratory chain complex IV assembly. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 13. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6). FBgn0259725 Alliance Is expressed in adult head. FBgn0259726 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. FBgn0259727 Alliance Predicted to be active in mitochondrial intermembrane space. Orthologous to human CMC4 (C-X9-C motif containing 4). FBgn0259728 Alliance Predicted to enable metal ion binding activity. Predicted to be active in nucleus. Is expressed in organism. FBgn0259729 Alliance "Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human UBXN2B (UBX domain protein 2B)." FBgn0259730 FlyBase Gene Snapshot "tarsal-less 1A (tal-1A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization." FBgn0259731 FlyBase Gene Snapshot "tarsal-less 2A (tal-2A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization." FBgn0259732 FlyBase Gene Snapshot "tarsal-less 3A (tal-3A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization." FBgn0259733 FlyBase Gene Snapshot "tarsal-less AA (tal-AA) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization." FBgn0259734 FlyBase Gene Snapshot "Nostrin (Nost) encodes a lipid binding protein involved in epithelial cell differentiation, plasma membrane tubulation and adherens junction organization." FBgn0259735 Alliance Located in plasma membrane. Is expressed in adult brain; adult head; adult mushroom body; and spermatozoon. Orthologous to several human genes including FNDC3B (fibronectin type III domain containing 3B). FBgn0259736 Alliance Predicted to contribute to GTPase activator activity. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in germline cell and spermatozoon. FBgn0259737 Alliance Predicted to enable DNA endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination and resolution of meiotic recombination intermediates. Predicted to be active in cytoplasm and nucleoplasm. FBgn0259739 Alliance Is expressed in adult head. FBgn0259741 Alliance Predicted to be active in membrane. Orthologous to human TMEM256 (transmembrane protein 256). FBgn0259742 Alliance Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in organism. Orthologous to human KHNYN (KH and NYN domain containing); N4BP1 (NEDD4 binding protein 1); and NYNRIN (NYN domain and retroviral integrase containing). FBgn0259745 FlyBase Gene Snapshot "wech (wech) encodes a member of the RBCC/TRIM family of cytoplasmic multidomain proteins. It is a regulator of integrin-mediated adhesion. It interacts with the products of rhea and Ilk, which are components of the integrin-cytoskeleton link." FBgn0259748 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0259749 FlyBase Gene Snapshot "mummy (mmy) encodes an UDP-N-acetylglucosamine diphosphorylase. It functions in apical extracellular matrix formation by producing GlcNAc residues needed for chitin synthesis and protein glycosylation. It regulates cuticle production, tracheal morphogenesis, and axon guidance." FBgn0259751 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259752 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259753 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259754 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259755 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259756 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259757 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259758 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259759 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259760 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259761 Alliance Involved in chromosome organization and spermatogenesis. FBgn0259785 FlyBase Gene Snapshot "putzig (pzg) encodes a nuclear protein that is involved in chromatin activation of replication related genes and signalling pathways including Notch, Ecdysone and JAK/STAT. It regulates growth, cell death and various developmental processes." FBgn0259789 FlyBase Gene Snapshot "zelda (zld) encodes a zinc finger transcription factor that functions in early blastoderm development. It works as a zygotic genome activator because it has a global role in regulating early expressed genes, such as genes essential for cellularization, sex determination and pattern formation. It is also required at later times in development." FBgn0259791 FlyBase Gene Snapshot aurora borealis (bora) encodes a binding partner of the product of aurA. It is required for spindle orientation and asymmetric cell division. FBgn0259794 UniProtKB E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for isoform beta of ttk that involves motifs in the C-terminus of ttk. (UniProtKB:Q8T3Y0) FBgn0259795 FlyBase Gene Snapshot loopin-1 (loopin-1) encodes a testis-specific protein with homology to several leucine aminopeptidases. Sequence analysis suggest that it doesn't have enzymatic activity. It accumulates inside the axoneme-associated mitochondrial derivative in mature sperms. FBgn0259817 Alliance Predicted to enable protein kinase regulator activity. Predicted to be part of protein kinase CK2 complex. FBgn0259818 Alliance Predicted to enable microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization and mitotic spindle assembly. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Is expressed in organism and spermatozoon. FBgn0259821 Alliance Predicted to enable carbohydrate binding activity. Orthologous to human EVA1C (eva-1 homolog C). FBgn0259823 Alliance "Predicted to be active in membrane. Is expressed in several structures, including embryonic/larval anterior midgut; embryonic/larval central nervous system; eye disc; gastric caecum; and larval ventral nerve cord." FBgn0259824 FlyBase Gene Snapshot Huntingtin-interacting protein 14 (Hip14) encodes a palmitoyltransferase which is required for host defense to bacterial infection. FBgn0259825 Alliance Involved in adult somatic muscle development. FBgn0259826 Alliance Involved in adult somatic muscle development. FBgn0259827 Alliance Involved in adult somatic muscle development. FBgn0259828 Alliance Involved in adult somatic muscle development. FBgn0259829 Alliance Involved in adult somatic muscle development. FBgn0259830 Alliance Involved in adult somatic muscle development. FBgn0259832 Alliance Predicted to be active in mitochondrion. Orthologous to human LYRM2 (LYR motif containing 2). FBgn0259834 FlyBase Gene Snapshot outsiders (out) encodes a monocarboxylate transporter involved in programmed cell death of primordial germ cell/pole cells. FBgn0259876 FlyBase Gene Snapshot "Chromosome associated protein G (Cap-G) encodes a component of the condensin I complex, necessary for accurate mitotic and meiotic chromosome segregation." FBgn0259878 FlyBase Gene Snapshot Follistatin (Fs) encodes a secreted protein that inhibits activin and decapentaplegic receptor signaling pathways but enhances signaling mediated by the Activin-like protein encoded by daw. FBgn0259896 Interactive Fly EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria FBgn0259918 FlyBase Gene Snapshot "inaF-B (inaF-B) encodes one of the four isoforms at the InaF locus, which contains four small ORFs named inaF-A, inaF-B, inaF-C, and inaF-D, each of which is spliced to the same down-stream exon. Mutations in inaF-B and inaF-C greatly suppress the expression of photoreceptor channel protein trp. inaF-B and inaF-C co-immunolocalize with trp to the rhabdomeres, structures containing the photoreceptors." FBgn0259922 Alliance Predicted to enable chromatin binding activity. Predicted to be involved in chromosome organization. Predicted to be located in nucleus. Predicted to be part of chromatin. FBgn0259923 Alliance "Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of exocytosis. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Is expressed in several structures, including adult head; brain; central brain primordium; dopaminergic neurons; and embryonic dorsal vessel. Orthologous to several human genes including SEPTIN4 (septin 4) and SEPTIN5 (septin 5)." FBgn0259927 Alliance Predicted to enable GTPase activator activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be active in cytoplasm; neuron projection; and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to several human genes including RGS9 (regulator of G protein signaling 9). FBgn0259932 Alliance Is expressed in embryonic/larval midgut and organism. Orthologous to human SMIM13 (small integral membrane protein 13). FBgn0259933 Alliance "Predicted to enable enzyme regulator activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory)." FBgn0259935 Alliance Predicted to enable RNA binding activity. Predicted to be involved in RNA stabilization. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in T4 neuron; T5 neuron; medullary tangential neuron Mt1; and transmedullary Y neuron TmY8. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including RALYL (RALY RNA binding protein like); HNRNPCL3 (heterogeneous nuclear ribonucleoprotein C like 3); and HNRNPCL4 (heterogeneous nuclear ribonucleoprotein C like 4). FBgn0259936 Alliance Predicted to be involved in RNA processing. Predicted to be located in nucleolus. FBgn0259937 FlyBase Gene Snapshot "Nucleolar protein at 60B (Nop60B) encodes a pseudouridine synthase that is a core component of H/ACA small nucleolar ribonucleoproteins (snoRNPs) and small Cajal body-specific ribonucleoproteins (scaRNPs). It is involved in pseudouridylation of cellular RNA, ribosome biogenesis, translation efficiency, cell proliferation, stress response and stem cell maintenance." FBgn0259938 FlyBase Gene Snapshot clockwork orange (cwo) encodes a basic-helix-loop-helix-Orange transcription factor that can both activate and repress transcription. It regulates rhythmic gene expression within the transcriptional feedback loop that keeps circadian time. FBgn0259949 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. FBgn0259950 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Is expressed in embryonic/larval crystal cell and procrystal cell. FBgn0259951 Alliance Predicted to enable peptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. FBgn0259952 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0259953 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Is expressed in adult head. FBgn0259954 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0259955 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0259956 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0259957 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0259958 Alliance Predicted to enable carbohydrate binding activity. Involved in sexual reproduction. Located in extracellular space. Orthologous to human CLEC6A (C-type lectin domain containing 6A); CLEC4D (C-type lectin domain family 4 member D); and CLEC4E (C-type lectin domain family 4 member E). FBgn0259959 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259962 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259963 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259964 Alliance Predicted to enable enzyme inhibitor activity. Involved in sexual reproduction. Located in extracellular space. FBgn0259965 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0259966 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259967 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259968 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0259969 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259970 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259972 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259973 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259974 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0259975 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0259976 Alliance Involved in oogenesis and spermatogenesis. FBgn0259977 FlyBase Gene Snapshot Tyrosine decarboxylase 1 (Tdc1) encodes a protein involved in behavioral response to ethanol. FBgn0259978 FlyBase Gene Snapshot vulcan (vlc) is induced above a basal level by 20-hydroxyecdysone in late third instar larvae. Its mutants die primarily as pharate adults with defects in ecdysone-induced leg morphogenesis. FBgn0259980 Alliance Involved in spermatogenesis. FBgn0259982 FlyBase Gene Snapshot Uxt prefoldin-like subunit (Uxt) encodes a protein that suppresses growth of larval neuromuscular junctions via an unknown mechanism. FBgn0259984 FlyBase Gene Snapshot kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. FBgn0259985 FlyBase Gene Snapshot Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. FBgn0259986 FlyBase Gene Snapshot nab (nab) encodes a transcriptional co-factor that acts in combination with the transcriptional factors encoded by rn in proximal-distal wing patterning and the product of sqz in CNS development. FBgn0259989 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. FBgn0259991 Alliance Orthologous to human TMEM141 (transmembrane protein 141). FBgn0259994 Interactive Fly "proton channel - mediates acid taste - functions in distinct subsets of gustatory receptor neurons for repulsion and attraction to high and low levels of protons, respectively" FBgn0259998 Alliance Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). FBgn0260001 Alliance "Located in cytoplasm. Is expressed in several structures, including epithelium; gut section; primordial germ cell; and terminal tracheal cell." FBgn0260002 FlyBase Gene Snapshot C/D box small nucleolar RNA 30b (snoRNA:CD30b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U2204 in 28SrRNA:CR45844. FBgn0260003 FlyBase Gene Snapshot "Dystrophin (Dys) encodes a cytoplasmic protein that connects the actin cytoskeleton to the extracellular matrix via the receptor encoded by Dg. In addition, the product of Dys serves as a cytoplasmic scaffold for the membrane localization of different signaling factors, including nanos, which regulates expression of miRNAs to adapt cellular homeostasis to changes induced by stress and dystrophy." FBgn0260004 FlyBase Gene Snapshot Sensory neuron membrane protein 1 (Snmp1) encodes a member of the CD36 family of lipoprotein receptors. It is expressed in a subset of olfactory neurons. It is required for a normal olfactory response to the male-specific pheromone 11-cis vaccenyl acetate. FBgn0260005 FlyBase Gene Snapshot water witch (wtrw) encodes a protein involved in response to humidity and sound perception. FBgn0260006 FlyBase Gene Snapshot drop dead (drd) encodes an integral membrane protein required for female fertility and for proper function of the gut and respiratory tracheae. FBgn0260008 Alliance "Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to human UQCRH (ubiquinol-cytochrome c reductase hinge protein) and UQCRHL (ubiquinol-cytochrome c reductase hinge protein like)." FBgn0260011 FlyBase Gene Snapshot Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. FBgn0260012 FlyBase Gene Snapshot "precocious dissociation of sisters 5 (pds5) encodes a protein that interacts with the product of wapl to form the releasin complex, which enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. The product of pds5 influences gene activation and silencing through interactions with cohesin. It is also required to initiate and/or maintain sister chromatid cohesion." FBgn0260013 Alliance Involved in oocyte karyosome formation. FBgn0260015 Alliance Involved in oocyte karyosome formation. FBgn0260026 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0260027 Alliance Is expressed in adult head. Orthologous to human TMEM42 (transmembrane protein 42). FBgn0260049 FlyBase Gene Snapshot flare (flr) encodes the Drosophila Actin Interacting protein 1. It functions with the product of tsr (cofillin) to promote F-actin disassembly. FBgn0260080 Alliance "Involved in dorsal trunk growth, open tracheal system." FBgn0260094 Alliance "Involved in terminal branching, open tracheal system." FBgn0260095 Alliance "Involved in terminal branching, open tracheal system." FBgn0260098 Alliance "Involved in terminal branching, open tracheal system." FBgn0260100 Alliance "Involved in dorsal trunk growth, open tracheal system." FBgn0260103 Alliance "Involved in lumen formation, open tracheal system." FBgn0260107 Alliance "Involved in terminal branching, open tracheal system." FBgn0260108 Alliance "Involved in terminal branching, open tracheal system." FBgn0260109 Alliance "Involved in terminal branching, open tracheal system." FBgn0260110 Alliance "Involved in terminal branching, open tracheal system." FBgn0260118 Alliance "Involved in terminal branching, open tracheal system." FBgn0260119 Alliance "Involved in lumen formation, open tracheal system." FBgn0260120 Alliance "Involved in terminal branching, open tracheal system." FBgn0260222 Alliance Predicted to enable copper ion binding activity. Predicted to be involved in metal ion transport and mitochondrial cytochrome c oxidase assembly. Predicted to be located in cytosol. Predicted to be active in mitochondrial intermembrane space. Is expressed in organism. Orthologous to human COX19 (cytochrome c oxidase assembly factor COX19). FBgn0260223 Alliance Predicted to be involved in regulation of dopamine metabolic process. Predicted to be located in mitochondrion. Is expressed in anterior midgut primordium; embryonic hindgut; embryonic/larval midgut; organism; and posterior midgut primordium. FBgn0260224 Alliance Predicted to be involved in tRNA threonylcarbamoyladenosine metabolic process. Predicted to be part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 2. Orthologous to several human genes including LAGE3 (L antigen family member 3). FBgn0260226 Alliance Predicted to be involved in defense response. FBgn0260229 UniProtKB "Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with Mocs2B, the sulfur is then transferred to precursor Z to form molybdopterin. (UniProtKB:P0C919)" FBgn0260233 Alliance "Is expressed in several structures, including dorsal ectoderm; embryonic/larval midgut primordium; embryonic/larval muscle cell; ganglia; and gut section." FBgn0260234 Alliance Involved in protein localization to plasma membrane; protein localization to rhabdomere; and protein transport. Located in endoplasmic reticulum membrane and subrhabdomeral cisterna. Part of endoplasmic reticulum chaperone complex. Is expressed in Bolwig organ. FBgn0260237 Alliance Predicted to be involved in cilium assembly and receptor localization to non-motile cilium. Predicted to be part of BBSome. Is expressed in adult head. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 18. Orthologous to human BBIP1 (BBSome interacting protein 1). FBgn0260242 Alliance Involved in double-strand break repair via single-strand annealing. FBgn0260243 Alliance Predicted to enable zinc ion binding activity. Involved in chromatin organization. Predicted to be active in nucleus. Is expressed in organism. FBgn0260386 FlyBase Gene Snapshot mind the gap (mtg) encodes a protein involved in synapse assembly. FBgn0260388 Alliance "Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic central brain neurons; embryonic dorsal epidermis; embryonic/larval nervous system; and ganglia. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3)." FBgn0260390 Alliance Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Is expressed in gnathal primordium; organism; and ventral ectoderm. Orthologous to human GTF3C6 (general transcription factor IIIC subunit 6). FBgn0260392 Alliance Is expressed in adult heart and organism. Orthologous to human NCBP2AS2 (NCBP2 antisense 2 (head to head)). FBgn0260393 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0260397 FlyBase Gene Snapshot "Suppressor of variegation 3-3 (Su(var)3-3) encodes a member of the Lysine specific demethylase (LSD1/KDM1) family. It can function both as a transcriptional co-repressor and a co-activator. It demethylates histone H3K4-me2 and -me1 residues, and promotes heterochromatin formation by facilitating H3K9 methylation mediated by the product of Su(var)3-9. It is involved in fertility, wing patterning formation and bristle specification." FBgn0260398 FlyBase Gene Snapshot "PSEA-binding protein 49kD (Pbp49) encodes a protein that functions as one of three subunits of the small nuclear RNA (snRNA) activating protein complex, which binds as a complex to a proximal sequence element A (PSEA) to activate transcription of snRNA genes." FBgn0260399 FlyBase Gene Snapshot "greatwall (gwl) encodes a kinase required for mitosis and female meiosis. It phosphorylates the product of endos, which then acts as a stoichiometric inhibitor of the PP2A B-type adaptor subunit encoded by tws." FBgn0260400 FlyBase Gene Snapshot "embryonic lethal abnormal vision (elav) encodes the founding member of a family of prototype RNA binding proteins homologous to human Hu proteins, and acting as gene-specific regulators of many aspects of mRNA processing. Drosophila has three members in this family, elav, fne and Rbp9, which are predominantly pan-neuronal. elav has roles in axon guidance, synapse formation and photoreceptor differentiation." FBgn0260401 UniProtKB "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (UniProtKB:A1ZB42)" FBgn0260407 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult heart. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 46. Orthologous to human MRPS23 (mitochondrial ribosomal protein S23). FBgn0260430 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0260431 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. FBgn0260434 Alliance Enables K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. FBgn0260486 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Involved in compound eye development. Is expressed in adult head and spermatozoon. Orthologous to human DOCK10 (dedicator of cytokinesis 10); DOCK11 (dedicator of cytokinesis 11); and DOCK9 (dedicator of cytokinesis 9). FBgn0260488 Alliance Involved in fasciculation of sensory neuron axon. FBgn0260489 Alliance Involved in dendrite morphogenesis and fasciculation of sensory neuron axon. FBgn0260490 Alliance Involved in axonogenesis and dendrite morphogenesis. FBgn0260491 Alliance Involved in axonogenesis and dendrite morphogenesis. FBgn0260492 Alliance Involved in axonogenesis. FBgn0260493 Alliance Involved in axonogenesis. FBgn0260494 Alliance Involved in axonogenesis. FBgn0260495 Alliance Involved in dendrite morphogenesis. FBgn0260499 FlyBase Gene Snapshot "quiver (qvr) encodes a Ly-6 protein. Ly-6 proteins are GPI-linked or secreted proteins that modulate the trafficking and/or activity of membrane protein targets, including the potassium channel encoded by Sh and nicotinic acetylcholine receptors." FBgn0260632 FlyBase Gene Snapshot "dorsal (dl) encodes a transcription factor that functions with the product of Dif, downstream of the Toll pathway. It contributes to certain functions of the Toll pathway, notably the dorsoventral patterning of early embryo." FBgn0260634 FlyBase Gene Snapshot eukaryotic translation initiation factor 4G2 (eIF4G2) encodes an eIF4G homolog involved in regulation of translation initiation within male germ cells. It is required for spermatogenesis. FBgn0260635 FlyBase Gene Snapshot Death-associated inhibitor of apoptosis 1 (Diap1) encodes an E3 ubiquitin ligase with a caspase inhibitor activity that is involved in the control of apoptosis. FBgn0260639 FlyBase Gene Snapshot "gamma-Tubulin at 23C (gammaTub23C) encodes the predominant member of the multi-protein gamma-tubulin ring complex (gammaTuRC), which templates the nucleation of microtubules." FBgn0260642 FlyBase Gene Snapshot "Antennapedia (Antp) is the distal-most member of the Antennapedia complex; one of two Hox gene complexes. Antp encodes a sequence-specific homeodomain transcription factor, which is part of a developmental regulatory system that specifies segmental identity in the pro- and mesothorax. In adults Antp loss of function is associated with a transformation of leg into antenna while ectopic expression in the head is associated with antenna to leg and eye to wing transformations." FBgn0260645 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0260646 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. FBgn0260648 FlyBase Gene Snapshot Ribosomal RNA processing 40 (Rrp40) encodes a protein involved in gene expression regulation. FBgn0260653 FlyBase Gene Snapshot serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length. FBgn0260655 Alliance Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus. Part of TRAPPIII protein complex. Is expressed in adult head. Orthologous to human TRAPPC8 (trafficking protein particle complex subunit 8). FBgn0260657 Alliance Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human STOM (stomatin) and STOML3 (stomatin like 3). FBgn0260658 Alliance Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be active in plasma membrane. FBgn0260659 Alliance Predicted to enable calcium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Predicted to be involved in Golgi calcium ion homeostasis and metal ion transport. Predicted to be active in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIk. Orthologous to human TMEM165 (transmembrane protein 165). FBgn0260660 FlyBase Gene Snapshot "Multiplexin (Mp) encodes a Collagen XV/XVIII type protein that functions in motor axon pathfinding. It is required for normal calcium channel abundance, presynaptic calcium influx, and neurotransmitter release." FBgn0260741 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism." FBgn0260742 Alliance Is expressed in adult head. FBgn0260743 FlyBase Gene Snapshot Glutamate Carrier 1 (GC1) encodes a carrier protein of the inner mitochondrial membrane that transports L-glutamate either with H[+] or in exchange for OH[-]. It operates during uricogenesis and has an essential role in the mitochondrial glutamate metabolism. FBgn0260744 Alliance Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Involved in protein secretion. Located in Golgi apparatus. Is expressed in adult head and adult heart. Orthologous to human SLC35F6 (solute carrier family 35 member F6). FBgn0260745 FlyBase Gene Snapshot midline fasciclin (mfas) encodes a protein involved in axonogenesis and regulation of hemocyte proliferation. FBgn0260746 Alliance "Predicted to enable beta-galactosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in vacuole. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; head epidermis primordium; and midline glial cell. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to several human genes including GLB1L (galactosidase beta 1 like)." FBgn0260747 Alliance "Involved in cellular response to oxidative stress and positive regulation of mitochondrial ATP synthesis coupled electron transport. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain; adult brain cell body rind; adult gnathal ganglion; embryonic/larval somatic muscle cell; and gut section. Used to study Parkinson's disease; Parkinson's disease 22; frontotemporal dementia and/or amyotrophic lateral sclerosis 2; and spinal muscular atrophy, Jokela type. Human ortholog(s) of this gene implicated in Parkinson's disease 22; frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Orthologous to several human genes including CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2)." FBgn0260748 Alliance Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to several human genes including PHLDB1 (pleckstrin homology like domain family B member 1). FBgn0260749 FlyBase Gene Snapshot "Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers." FBgn0260750 FlyBase Gene Snapshot Multi-substrate lipid kinase (Mulk) encodes a ceramide kinase involved in ceramide metabolism and pole cell migration. FBgn0260753 FlyBase Gene Snapshot "Pigment-dispersing factor receptor (Pdfr) encodes a G-Protein Coupled Receptor in the Family B class of GPCRs (Secretin Receptor-like) that can be activated by the product of Pdf. It has been implicated in regulation of circadian physiology, development of the flight motor system, and regulation of mating." FBgn0260755 Alliance Orthologous to human C7orf25 (chromosome 7 open reading frame 25). FBgn0260756 Alliance Predicted to be involved in autophagy. Orthologous to human NRBF2 (nuclear receptor binding factor 2). FBgn0260758 Alliance Predicted to be involved in cobalamin metabolic process. FBgn0260759 Alliance Predicted to be involved in cilium organization. FBgn0260766 FlyBase Gene Snapshot CG42564 encodes a predicted cysteine-rich secretory protein that is produced in the male accessory gland and transferred to females during mating. FBgn0260767 Alliance Predicted to enable zinc ion binding activity. FBgn0260771 FlyBase Gene Snapshot La related protein 7 (Larp7) encodes an obligate component of the 7SK snRNP. The 7SK snRNP plays an essential role in RNA polymerase II elongation control by regulating the activity of the positive transcription elongation factor complex encoded by Cdk9 and CycT. FBgn0260775 UniProtKB May play an important function during spermatogenesis and/or in the male genital tract. (UniProtKB:P92029) FBgn0260779 UniProtKB Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (UniProtKB:Q9VE09) FBgn0260780 FlyBase Gene Snapshot "wispy (wisp) encodes a conserved cytoplasmic poly-A polymerase of the GLD2 family that is expressed in the female germline and, at low levels, in the nervous system. Its maternal germline expression is essential for completion of normal meiosis by oocytes at egg activation. The product of wisp elongates the poly-A tails of many mRNAs during egg activation. This activity is essential for the translation of maternal mRNAs." FBgn0260789 FlyBase Gene Snapshot "multi sex combs (mxc) encodes a Cylin E/Cdk2 substrate and molecular scaffold that is necessary for assembly of the histone locus body, which is a nuclear body associated with replication dependent histone gene clusters that contains factors necessary for the transcription and processing of histone mRNA." FBgn0260793 FlyBase Gene Snapshot "2mit (2mit) encodes a putative leucine-rich repeat transmembrane protein that is mainly expressed in the developing central nervous system. In the adult, it has a role in short-term memory." FBgn0260794 FlyBase Gene Snapshot circadian trip (ctrip) encodes a HECT ubiquitin ligase that regulates the levels and circadian oscillations of the transcriptional activator encoded by Clk. It plays a role in the control of rest-activity rhythms. FBgn0260795 FlyBase Gene Snapshot Na[+]-dependent inorganic phosphate cotransporter type III (NaPi-III) encodes a transporter involved in sodium-dependent phosphate transmembrane transport. FBgn0260798 UniProtKB Specifically phosphorylates the activated forms of G protein-coupled receptors. (UniProtKB:P32865) FBgn0260799 FlyBase Gene Snapshot "p120 catenin (p120ctn) encodes an important modulator of cell adhesion. It binds to and stabilizes classic cadherin cell adhesion receptors at the cell surface. Unlike its mammalian homologs, it is non-essential but becomes essential if the levels of the product of shg are reduced." FBgn0260812 FlyBase Gene Snapshot "inaF-D (inaF-D) encodes one of the four isoforms at the InaF locus, which contains four small ORFs named inaF-A, inaF-B, inaF-C, and inaF-D, each of which is spliced to the same down-stream exon. Contrary to the other isoforms, the biological role of inaF-D is poorly understood." FBgn0260817 FlyBase Gene Snapshot Tyrosyl-DNA phosphodiesterase 1 (Tdp1) encodes a member of the phospholipase D superfamily. It is essential for the formation of epithelial polarity and nervous system development. FBgn0260855 FlyBase Gene Snapshot Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion. FBgn0260856 UniProtKB Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (UniProtKB:Q9VRL2) FBgn0260857 Alliance Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to be part of SNARE complex. Is expressed in adult head. Orthologous to human BET1 (Bet1 golgi vesicular membrane trafficking protein). FBgn0260858 FlyBase Gene Snapshot "YKT6 v-SNARE (Ykt6) encodes an R-SNARE localized to the Golgi apparatus and endosomes/lysosomes, to regulate the bi-directional transport between the endoplasmic reticulum and the Golgi apparatus. Ykt6 can form a prefusion SNARE complex with Syx17 and Snap29, to promote the fusion of autophagosomes with lysosomes. Through interaction with Syx13 and Snap29, it also mediates the fusion of Lamp1 carriers and secretory granules." FBgn0260859 FlyBase Gene Snapshot Blocked early in transport 3 (Bet3) encodes a protein involved in dsRNA transport. FBgn0260860 Alliance Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Orthologous to human TRAPPC1 (trafficking protein particle complex subunit 1). FBgn0260861 Alliance Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Is expressed in adult head. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). FBgn0260862 FlyBase Gene Snapshot Vesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking. FBgn0260866 FlyBase Gene Snapshot defense repressor 1 (dnr1) encodes a protein that interacts with the caspase encoded by Dredd. The product of dnr1 is involved in attenuation of innate immune response and neuro-inflammation. FBgn0260874 Alliance Contributes to olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception of smell and transmission of nerve impulse. Located in sensory dendrite. Part of receptor complex. Is expressed in adult olfactory receptor neuron Ir76a; antennal coeloconic sensillum ac4; and antennal lobe glomerulus VM4. FBgn0260932 FlyBase Gene Snapshot "cutoff (cuff) encodes a protein that interacts with the products of rhi and del in a germline complex that allows noncanonical transcription of dual-strand piRNA clusters. The product of cuff is therefore an integral part of the piRNA response to transposon activity in the germline. In its absence, a DNA damage checkpoint is activated leading to ventralization of the egg and embryo." FBgn0260933 FlyBase Gene Snapshot "reduced mechanoreceptor potential A (rempA) encodes the IFT140 subunit of the IFT-A subcomplex. As such, it is a component of the conserved intraflagellar transport (IFT) mechanism and is needed to extend cilia above the cell surface." FBgn0260934 FlyBase Gene Snapshot "par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization." FBgn0260935 FlyBase Gene Snapshot "Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis." FBgn0260936 UniProtKB "Hydrolase that deubiquitinates polyubiquitinated target proteins including imd (PubMed:19039105, PubMed:19837371). Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions (PubMed:19837371, PubMed:25027767). Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade (PubMed:19837371). Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys-48'-linked chains which act as 'tags' the for proteasomal degradation of imd (PubMed:19837371). Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells (PubMed:19039105). May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4me3) (PubMed:19039105). Controls selective autophagy activation by ubiquitinated proteins (PubMed:22622177). (UniProtKB:Q9VRP5)" FBgn0260938 FlyBase Gene Snapshot "tay bridge (tay) encodes a nuclear protein acting in the MAP kinase pathway by preventing the product of rl activation. It is present in most cell types, and accumulates strongly in differentiated neurons." FBgn0260940 FlyBase Gene Snapshot "larsen (lsn), also known as Vacuolar protein sorting 22, encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, it also has a role in bcd RNA localization." FBgn0260941 FlyBase Gene Snapshot approximated (app) encodes a palmitoyltransferase involved in planar cell polarity. It regulates Fat signaling and the localization and activity of the product of dachs. FBgn0260942 FlyBase Gene Snapshot james bond (bond) encodes a member of the Elov1 family of enzymes that function as very long chain fatty acid elongases. It contributes to sperm generation and the production of the male sex pheromone CH503 in the ejaculatory bulb. FBgn0260943 FlyBase Gene Snapshot "RNA-binding protein 6 (Rbp6) encodes a paralog of the RNA-binding protein encoded by msi. In contrast to msi, Rbp6 mutants are viable and fertile, with only a slight delay in eclosion. The product of Rbp6 may have roles in response to fungal infection and aggressive behavior." FBgn0260944 UniProtKB Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. (UniProtKB:Q02427) FBgn0260945 FlyBase Gene Snapshot Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of mTor in the regulation of autophagy. FBgn0260953 Alliance Predicted to enable ubiquitin protein ligase activity. FBgn0260954 Alliance Is expressed in amnioserosa; embryonic/larval fat body; and yolk nucleus. FBgn0260959 FlyBase Gene Snapshot Microcephalin (MCPH1) encodes a BRCT domain-containing protein that acts in genome stability and cell cycle regulation. It is required to co-ordinate centrosome and nuclear division during rapid syncitial embryonic cell divisions. FBgn0260960 FlyBase Gene Snapshot Baldspot (Baldspot) encodes a protein involved in spermatogenesis. FBgn0260962 FlyBase Gene Snapshot "piccolo (pic) encodes the Ddb1 protein, which functions to recruit substrate receptors to Cul4-based E3 ubiquitin ligase complexes, which catalyze the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome." FBgn0260964 FlyBase Gene Snapshot "Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles." FBgn0260965 Alliance Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Is expressed in spermatozoon. Orthologous to human GTF3C2 (general transcription factor IIIC subunit 2). FBgn0260970 UniProtKB "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:26383956, PubMed:27195754). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (PubMed:26383956, PubMed:27195754). Binds to the E3 ubiquitin-protein ligase Diap1 and enhances its ubiquitination and anti-apoptotic functions (PubMed:25146930). Essential during trichome development for the ubiquitination of the N-terminus of ovo isoform B (svb), converting it from a transcriptional inhibitor to an activator (PubMed:26383956). Positively regulates a hh-signaling pathway which functions in photoreceptor differentiation (PubMed:27195754). Activation of hh up-regulates transcription of Ubr3, which in turn promotes hh signaling by mediating the ubiquitination and degradation of cos (PubMed:27195754). Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in the regulation of zip and ck function in scolopidial apical attachment (PubMed:27331610). Likely to function by acting in a pathway that negatively regulates the ubiquitination of zip, consequently affecting its interaction with ck (PubMed:27331610). May also negatively regulate a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex Cul1, which also appears to function in the negative regulation of the zip-ck interaction and scolopidial apical attachment (PubMed:27331610). (UniProtKB:Q9W3M3)" FBgn0260971 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0260972 Interactive Fly regulatory subunit of AMP-activated protein kinase - regulation of cellular energy homeostasis - maintainance of integrity of mature neurons under conditions of increased activity - regulation of developmental and stress-induced autophagy FBgn0260985 UniProtKB The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP. (UniProtKB:P53034) FBgn0260986 FlyBase Gene Snapshot meiotic 38 (mei-38) encodes a microtubule-associated protein that functions in mitosis and meiosis. FBgn0260987 FlyBase Gene Snapshot "verthandi (vtd) encodes a subunit of the cohesin complex, which encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair." FBgn0260990 Interactive Fly "kinase domain (inactive) - controls intracellular trafficking of the APPL protein - mislocalized Yata causes the mislocalization of COPI, indicating that YATA plays a role in directing COPI to the proper subcellular site - abnormal cellular structures are located in the vicinity of rhabdomeres in aged white; yata mutants - expression of APP resulted in the loss of proper control of synapse formation, which is reversed in yata mutants - secretory vesicles" FBgn0260991 FlyBase Gene Snapshot "Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis." FBgn0260995 Alliance Involved in synapse organization. Predicted to be active in neuron projection membrane. FBgn0261004 FlyBase Gene Snapshot "asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation." FBgn0261006 FlyBase Gene Snapshot C/D box small nucleolar RNA 65 (snoRNA:CD65) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0261015 Alliance "Involved in sperm individualization. Located in investment cone and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; epithelium; gut section; and head epidermis primordium." FBgn0261016 FlyBase Gene Snapshot "closca (clos) encodes a protein that is required, together with the products of fs(1)N and fs(1)M3, for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation." FBgn0261019 FlyBase Gene Snapshot "modigliani (moi) encodes a fast evolving, not evolutionary conserved, protein required for telomere maintenance. It is a member of terminin capping-complex that prevents telomere fusions." FBgn0261020 FlyBase Gene Snapshot wollknaeuel (wol) encodes a protein belonging to the the glycosyltransferase 2 family. It contributes to N-glycan biosynthesis and is involved in epidermal differentiation including maintenance of cell polarity and cuticle formation. FBgn0261041 FlyBase Gene Snapshot straightjacket (stj) encodes a voltage-gated calcium channel subunit involved in neuromuscular junction development and autophagosome maturation. FBgn0261046 FlyBase Gene Snapshot Down syndrome cell adhesion molecule 3 (Dscam3) encodes a large transmembrane protein that functions in homophilic cell adhesion. It may also function as an axon guidance receptor. FBgn0261049 FlyBase Gene Snapshot Vacuolar protein sorting 45 (Vps45) encodes an SM protein that is activated by the product of Rab5 and binds to the product of Rbsn-5 to control entry of endocytosed cargo into the early endosome. FBgn0261053 FlyBase Gene Snapshot "Cadherin 86C (Cad86C) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication." FBgn0261054 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. FBgn0261055 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0261057 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0261058 Alliance Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. FBgn0261059 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0261060 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0261061 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0261064 FlyBase Gene Snapshot Rabenosyn-5 (Rbsn-5) encodes a Rab5-binding effector that controls entry of endocytosed cargo into the early endosome. FBgn0261065 UniProtKB "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as an mRNA 3'-end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. (UniProtKB:Q9VE51)" FBgn0261067 Alliance "Predicted to enable mRNA binding activity. Involved in P-body assembly. Predicted to be part of Lsm1-7-Pat1 complex. Predicted to be active in P-body. Orthologous to human LSM1 (LSM1 homolog, mRNA degradation associated)." FBgn0261068 Alliance "Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in embryonic brain; embryonic/larval midgut; embryonic/larval muscle system; and organism. Orthologous to human LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)." FBgn0261085 Alliance "Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in calcium-ion regulated exocytosis. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in indirect flight muscle cell. Orthologous to human SYT12 (synaptotagmin 12)." FBgn0261086 Alliance Predicted to enable phospholipid binding activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 11. Orthologous to several human genes including SYT16 (synaptotagmin 16). FBgn0261089 Alliance "Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in calcium-ion regulated exocytosis. Located in plasma membrane. Is expressed in adult head." FBgn0261090 Alliance "Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in calcium-ion regulated exocytosis and synaptic vesicle exocytosis. Predicted to be located in membrane and synaptic vesicle. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult neuromere; synaptic neuropil domain; and synaptic neuropil layer. Orthologous to human SYT13 (synaptotagmin 13)." FBgn0261108 FlyBase Gene Snapshot "Autophagy-related 13 (Atg13) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation." FBgn0261109 FlyBase Gene Snapshot marionette (mrn) encodes a subunit of the basal transcription and DNA repair factor TFIIH. FBgn0261111 FlyBase Gene Snapshot Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. FBgn0261112 UniProtKB "Regulatory subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Appl and APP-BP1 interact antagonistically during development. (UniProtKB:Q9VTE9)" FBgn0261113 FlyBase Gene Snapshot "Xrp1 (Xrp1) encodes an AT-Hook, bZip DNA binding protein involved in genome stability maintenance. It heterodimerizes with the product of Irbp18 to bind to P element sequences contributing to transposition. It is induced by p53 following X-irradiation and by mutations or knockdown of caz or ribosomal protein (Rp) encoding genes. It contributes to the slow growth of Minute (Rp+/-) mutants cell-autonomously by inhibiting translation and non-autonomously through regulation of the product of Ilp8." FBgn0261119 FlyBase Gene Snapshot Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation. FBgn0261238 FlyBase Gene Snapshot Alhambra (Alh) encodes a zinc finger/leucine zipper nuclear protein. It is required in the nervous system for maintaining eve expression and normal growth. It is also involved in muscle development and male courtship behavior. FBgn0261239 FlyBase Gene Snapshot "Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions." FBgn0261243 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; ganglia; and male germline cell. Orthologous to several human genes including NPEPPS (aminopeptidase puromycin sensitive)." FBgn0261244 FlyBase Gene Snapshot inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. FBgn0261245 FlyBase Gene Snapshot "singles bar (sing) encodes a small multipass transmembrane protein that is required for muscle fusion in embryonic and adult stages. It is needed for progression beyond the pre-fusion complex stage of myoblast fusion, possibly by delivering fusion machinery components by vesicle fusion." FBgn0261258 Alliance Predicted to enable carbohydrate binding activity. Involved in tissue regeneration. Predicted to be active in endosome; trans-Golgi network; and trans-Golgi network transport vesicle. Is expressed in adult heart and prothoracic leg disc. FBgn0261260 FlyBase Gene Snapshot Megalin (mgl) encodes a protein involved in cuticle development and endocytosis regulation. FBgn0261261 FlyBase Gene Snapshot pollux (plx) encodes a Rab GTPase activating protein involved in cell adhesion mediated by integrins. FBgn0261262 Alliance Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0261266 FlyBase Gene Snapshot "zucchini (zuc) encodes a member of the phospholipase D superfamily. It is anchored in the outer mitochondrial membrane and functions in the processing of primary piRNA transcripts through its endonuclease activity. zuc depletion causes sterility, transposon de-repression and accumulation of piRNA cluster transcripts." FBgn0261268 Interactive Fly "Cullen-3 homolog acting in protein degradation - loss of function has pleiotropic effects during development, including defects in external sensory organ development, pattern formation and cell growth and survival - targets Cubitus interruptus" FBgn0261269 FlyBase Gene Snapshot convoluted (conv) encodes a leucine-rich repeat protein involved in axon guidance and the development of the tracheal system. FBgn0261270 FlyBase Gene Snapshot "Selenophosphate synthetase 1 (Sps1) encodes a protein that inhibits Gs1 and dmGlut expression, which in turn regulates the intracellular levels of glutamine." FBgn0261274 FlyBase Gene Snapshot Endoplasmic reticulum oxidoreductin-1-like (Ero1L) encodes a thiol oxidase that plays an important role in disulfide-bond formation. It oxidizes Pdi and mediates the oxidative protein folding in the endoplasmic reticulum. FBgn0261276 FlyBase Gene Snapshot Optic atrophy 1 (Opa1) encodes a dynamin-related GTPase that mediates fusion of the inner membrane of mitochondria. It usually works with the product of Marf to coordinately fuse both mitochondrial membranes. The product of Opa1 activity is regulated by proteolytic processing. FBgn0261277 FlyBase Gene Snapshot retroactive (rtv) encodes a membrane-inserted protein required for chitin organization in the cuticle and the tracheal system. FBgn0261278 FlyBase Gene Snapshot grapes (grp) encodes a protein that functions in a cell cycle checkpoint pathway that responds to DNA damage. FBgn0261279 FlyBase Gene Snapshot liquid facets-Related (lqfR) encodes a Golgi protein involved in cell proliferation and oogenesis. FBgn0261283 FlyBase Gene Snapshot Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. FBgn0261284 FlyBase Gene Snapshot boudin (bou) encodes a membrane glycoprotein of the Ly6 superfamily that is required for the formation of septate junctions in epithelial tissues. FBgn0261285 Alliance "Enables phosphopantothenate--cysteine ligase activity. Involved in several processes, including dorsal appendage formation; oogenesis; and phospholipid homeostasis. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; larval midline neurons; midline primordium; and organism. Used to study dilated cardiomyopathy and neurodegenerative disease. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2C. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase)." FBgn0261286 UniProtKB "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. (UniProtKB:Q8IH00)" FBgn0261287 Alliance "Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head." FBgn0261289 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in wing. FBgn0261290 Alliance Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0261291 Alliance Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0261292 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg. FBgn0261293 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg. FBgn0261294 Alliance Predicted to enable lipid binding activity. Involved in detection of pheromone. Predicted to be located in extracellular space. Is expressed in prothoracic leg. FBgn0261341 FlyBase Gene Snapshot vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control. FBgn0261349 Alliance Involved in spermatogenesis. Is expressed in primary spermatocyte; spermatid; and spermatocyte. FBgn0261353 FlyBase Gene Snapshot Coiled-coil domain containing 56 (Ccdc56) encodes a small mitochondrial protein required for cytochrome c oxidase assembly and function. FBgn0261358 Alliance Is expressed in spermatozoon. FBgn0261360 Alliance Predicted to enable guanylate cyclase activity and signaling receptor activity. Predicted to be involved in cGMP-mediated signaling. Predicted to be located in plasma membrane. Is expressed in adult head. FBgn0261361 Alliance "Enables intracellularly ligand-gated monoatomic ion channel activity; monoatomic cation channel activity; and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including autophagosome maturation; positive regulation of TOR signaling; and positive regulation of synaptic assembly at neuromuscular junction. Located in endolysosome membrane; late endosome membrane; and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis type IV. Orthologous to human MCOLN1 (mucolipin TRP cation channel 1); MCOLN2 (mucolipin TRP cation channel 2); and MCOLN3 (mucolipin TRP cation channel 3)." FBgn0261363 FlyBase Gene Snapshot Prophenoloxidase 3 (PPO3) is expressed in lamellocytes (a type of hemocyte cell involved in encapsulation) and its product involved in the melanization reaction during wasp encapsulation. FBgn0261373 Alliance Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. FBgn0261374 Alliance Enables catechol oxidase activity and tyrosinase activity. FBgn0261380 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human MRPL37 (mitochondrial ribosomal protein L37)." FBgn0261381 UniProtKB "Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. In contrast to mtTFB2, it does not have a critical role in either transcription or regulation of the copy number of mitochondrial DNA. (UniProtKB:Q9VTM5)" FBgn0261385 FlyBase Gene Snapshot "scraps (scra) encodes a homolog of anilin, a conserved pleckstrin homology domain (PLEKH) containing protein that binds actin, nonmuscle myosin II and microtubules. It stabilizes the contractile ring and is required for completion of cytokinesis." FBgn0261386 FlyBase Gene Snapshot "Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1." FBgn0261387 Alliance Predicted to enable calcium-dependent protein serine/threonine kinase activity; calmodulin binding activity; and calmodulin-dependent protein kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in X-linked lissencephaly 1 and subcortical band heterotopia. Orthologous to several human genes including DCLK1 (doublecortin like kinase 1) and DCLK2 (doublecortin like kinase 2). FBgn0261393 Alliance Enables carboxylesterase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). FBgn0261394 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:P18053)" FBgn0261395 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:Q9VA12)" FBgn0261396 UniProtKB Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (UniProtKB:P25161) FBgn0261397 FlyBase Gene Snapshot "dilute class unconventional myosin (didum) encodes a class V unconventional myosin that binds actin and hydrolyzes ATP. It functions in mRNA localization in the oocyte, spermatid individualization during spermatogenesis, transport of pigment granules in photoreceptors and mitochondrial transport in neuronal cells." FBgn0261399 Alliance Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in cyst cell of testis; organism; and testis. FBgn0261401 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Is expressed in antennal coeloconic sensillum ac3. FBgn0261402 Alliance Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Is expressed in antennal coeloconic sensillum ac3. FBgn0261403 FlyBase Gene Snapshot super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing. FBgn0261429 Alliance Is expressed in organism. FBgn0261434 FlyBase Gene Snapshot "huckebein (hkb) is expressed in patches within the embryonic neuroectoderm and a subset of neuroblasts and their progeny, where it is required for proper neuronal specification and axon targeting. It is a terminal gap gene mediating the maternal terminal information at the posterior end of the blastoderm embryo." FBgn0261436 UniProtKB "Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Also has 7,8-dihydropterin deaminase activity, which plays a role in synthesis of the red eye pigment aurodrosopterin. (UniProtKB:Q9VMY9)" FBgn0261437 FlyBase Gene Snapshot COP9 signalosome subunit 8 (CSN8) encodes the subunit 8 of the COP9 signalosome (CSN) and is essential for the stability of the complex. The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. FBgn0261439 FlyBase Gene Snapshot "Succinate dehydrogenase, subunit A (flavoprotein) (SdhA) encodes the FAD-containing subunit of the succinate dehydrogenase complex. It directly oxidizes succinate to fumarate and transfers the electrons to other subunits and eventually to quinones." FBgn0261444 UniProtKB Probable chloride channel. (UniProtKB:Q9W5A5) FBgn0261445 FlyBase Gene Snapshot "sugarless (sgl) encodes an UDP-glucose 6-dehydrogenase that catalyzes the conversion of UDP-D-glucose into UDP-D-glucuronate, a component of glycosaminoglycans. UDP-D-glucuronate is required for the biosynthesis of heparan sulfate and chondroitin sulfate proteoglycans." FBgn0261446 Alliance Is expressed in embryonic anal pad; embryonic/larval muscle system; gut section; and larval ventral nerve cord. FBgn0261452 Alliance Located in Cajal body. FBgn0261453 Alliance Enables snRNA 2'-O-ribose methylation guide activity. Located in Cajal body. FBgn0261454 Alliance Enables snRNA 2'-O-ribose methylation guide activity. Located in Cajal body. FBgn0261455 Alliance Located in Cajal body. FBgn0261456 FlyBase Gene Snapshot "hippo (hpo) encodes a kinase in the Salvador-Warts-Hippo pathway. It controls tissue growth by controlling cell growth, proliferation and apoptosis. It has several roles in post-mitotic cells including fate specification of photoreceptors and tiling of dendritic neurons." FBgn0261458 FlyBase Gene Snapshot capulet (capt) encodes a conserved actin binding protein that functions across eukaryotes to negatively regulate actin filament assembly. Different types of actin filament formation are differentially affected by the loss of capt. FBgn0261461 FlyBase Gene Snapshot Rho GTPase activating protein at 18B (RhoGAP18B) encodes a protein that can act as a GTPase activating protein for several Rho GTPase and is involved in the regulation of actin dynamics. FBgn0261477 UniProtKB Activates the Pk92B/DASK1-MAPK signaling cascade. (UniProtKB:A1ZB86) FBgn0261479 FlyBase Gene Snapshot nero (nero) encodes a deoxyhypusine hydroxylase enzyme that is required for the hypusination of eEF5 and is localized to the endoplasmic reticulum. It negatively regulates autophagy. FBgn0261503 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0261504 Alliance "Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting." FBgn0261509 FlyBase Gene Snapshot hattifattener (haf) encodes a large transmembrane leucine-rich repeat (LRR) protein whose mutants have variable motor axon defects in which ISNb motor axons fail to make the correct decisions at choice points. FBgn0261514 Alliance Predicted to be involved in phagocytosis. Predicted to be active in membrane. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1). FBgn0261524 FlyBase Gene Snapshot licorne (lic) encodes a serine/threonine kinase that phosphorylates p38 MAP kinases. FBgn0261526 UniProtKB "Neurotrophin which may function as a ligand for the Toll-related receptors Toll-7 and Tollo (PubMed:22022271, PubMed:23892553). Binds to Toll-7 and probably acts as its ligand in promoting motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons (PubMed:19018662). In larvae, involved in the negative regulation of the tracheal immune response to bacterial infection perhaps by acting as a ligand for the Toll-related receptor Tollo (PubMed:22022271). May be involved in the normal development of specific neurons at the neuromuscular junction (PubMed:24124519). (UniProtKB:B7TB45)" FBgn0261529 Alliance Involved in spermatid differentiation. Is expressed in spermatozoon. FBgn0261530 FlyBase Gene Snapshot "nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions." FBgn0261532 FlyBase Gene Snapshot cadmus (cdm) encodes a member of the importin beta family of nucleocytoplasmic cargo shuttling proteins. It functions at the neuromuscular junction to maintain normal subsynaptic reticulum structure and presynaptic probability of release. FBgn0261534 UniProtKB May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response. (UniProtKB:Q9V3Y3) FBgn0261535 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm. Orthologous to human NOL10 (nucleolar protein 10)." FBgn0261542 Alliance Involved in spermatogenesis. FBgn0261545 FlyBase Gene Snapshot CG42663 encodes a Nck-associated protein 5-like protein involved in determination of lifespan. FBgn0261547 FlyBase Gene Snapshot Ephexin (Exn) encodes a Eph-specific RhoGEF involved olfactory map formation. FBgn0261549 FlyBase Gene Snapshot "retinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport." FBgn0261550 Alliance "Predicted to enable cholesterol binding activity and phospholipid transporter activity. Predicted to be involved in phospholipid transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in cortical endoplasmic reticulum; cytosol; and membrane. Is expressed in several structures, including adult fat body; adult head; embryonic/larval midgut primordium; germline cell; and gut section. Orthologous to human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8)." FBgn0261552 FlyBase Gene Snapshot pasilla (ps) encodes a nuclear RNA binding protein implicated in splicing. It is expressed at high levels in the embryonic salivary gland and other tissues. Loss of function results in a significant reduction in secretory volume and secretory vesicles in the salivary gland and irregular gland morphology. FBgn0261553 Alliance Is expressed in organism. FBgn0261554 Alliance Predicted to enable PDZ domain binding activity and protein kinase regulator activity. Is expressed in adult head. Orthologous to human KIDINS220 (kinase D interacting substrate 220). FBgn0261555 UniProtKB Putative adapter protein. (UniProtKB:Q8SXX4) FBgn0261556 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Is expressed in leg and organism. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to several human genes including PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). FBgn0261560 FlyBase Gene Snapshot "Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation." FBgn0261561 Alliance Orthologous to human ZC2HC1A (zinc finger C2HC-type containing 1A) and ZC2HC1B (zinc finger C2HC-type containing 1B). FBgn0261562 Alliance Is expressed in organism. FBgn0261563 FlyBase Gene Snapshot "wing blister (wb) encodes one of 2 laminin alpha chains which assembles into a Laminin molecule. Laminin is an extracellular matrix component that interacts with integrins and mediates cell adhesion, guidance, signalling and basement membrane integrity." FBgn0261564 FlyBase Gene Snapshot Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. FBgn0261565 FlyBase Gene Snapshot "Limpet (Lmpt) is highly expressed in heart and muscle tissue. Lmpt homozygous knockouts are embryonic lethal, and have myocardial cell defects." FBgn0261570 UniProtKB "GTPase-activating protein, which acts as a negative regulator for some members of the Ras family (By similarity). Probably decreases their signaling activity by stimulating their intrinsic GTPase activity, thereby lowering the levels of the GTP-bound active form (By similarity). Functions with DE-cadherin (shg) to promote embryonic border cell (BC) migration and adhesion by regulating the distribution of actin protrusions in BCs (PubMed:30763317). Promotes shg-mediated adhesion at the BC interfaces and likely maintains BC cluster adhesion during BC detachment from the follicular epithelium and subsequent BC migration (PubMed:30763317). Also required for restricting the development of actin-rich protrusions to the front of migrating BC clusters thus ensuring unidirectional BC migration (PubMed:30763317). Possibly functions by suppressing Rac1 signaling in non-leading BCs, thus limiting its activity to leading BCs where it initiates localized actin cytoskeleton remodeling to produce the polarized protrusions (PubMed:30763317). (UniProtKB:Q8T498)" FBgn0261573 FlyBase Gene Snapshot CoRest (CoRest) encodes a DNA binding factor that controls transcription in cooperation with other transcriptional regulators. It positively modulates Notch signaling as well as showing co-repressor activity via histone modification regulation. FBgn0261574 FlyBase Gene Snapshot "kugelei (kug) (also known as Fat2 or Fat-like) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication. It is related to the product of ft and its roles include control of planar cell polarity, collective cell migration and morphogenesis." FBgn0261575 Alliance "Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult gut; adult head; and fat cell. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase (putative))." FBgn0261584 Alliance Predicted to be involved in proteolysis. FBgn0261588 FlyBase Gene Snapshot pou domain motif 3 (pdm3) encodes a POU domain transcription factor that acts in odor receptor gene expression and axon targeting of olfactory neurons. FBgn0261592 FlyBase Gene Snapshot Ribosomal protein S6 (RpS6) encodes a key component of the small (40S) ribosomal subunit. FBgn0261596 FlyBase Gene Snapshot Ribosomal protein S24 (RpS24) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. FBgn0261597 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Part of cytosolic small ribosomal subunit. Is expressed in adult head and adult heart. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 10. Orthologous to several human genes including RPS26 (ribosomal protein S26). FBgn0261599 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Part of cytosolic small ribosomal subunit. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 13. Orthologous to human RPS29 (ribosomal protein S29). FBgn0261602 FlyBase Gene Snapshot Ribosomal protein L8 (RpL8) encodes a ribosomal structural constituent. FBgn0261608 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including RPL37A (ribosomal protein L37a). FBgn0261609 FlyBase Gene Snapshot eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) encodes one of three subunits of the eIF-2 complex required for the initiation of translation. eIF2alpha is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. FBgn0261610 Alliance Predicted to be involved in cilium assembly. Predicted to be active in axonemal microtubule; centriole; and centrosome. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human CEP162 (centrosomal protein 162). FBgn0261612 FlyBase Gene Snapshot "Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies." FBgn0261617 FlyBase Gene Snapshot "nejire (nej) encodes the transcriptional co-activator CBP. It acetylates several nuclear proteins, including the histone encoded by His3 on K18, K27, and H4 on K8. By regulating gene expression, the product of nej has roles in cell proliferation, cell signaling and differentiation, and in developmental patterning." FBgn0261618 FlyBase Gene Snapshot La related protein (larp) encodes a protein that associates and interacts with poly(A)-binding protein. It is required for multiple processes in male meiosis and syncytial embryo development. FBgn0261624 Alliance Enables protein phosphatase 1 binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). FBgn0261625 Alliance "Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; ganglia; lamina anlage; midline primordium; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to several human genes including GLS (glutaminase)." FBgn0261628 Alliance Is expressed in adult head. FBgn0261630 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0261633 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. FBgn0261634 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0261638 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0261641 Alliance "Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including CNS glial cell; ganglia; head epidermis primordium; mesoderm; and sensory nervous system primordium. Orthologous to several human genes including TCERG1 (transcription elongation regulator 1)." FBgn0261647 FlyBase Gene Snapshot AXIN1 up-regulated 1 (Axud1) encodes a nuclear protein required to regulate cell proliferation rates and cell growth in the wing disc. FBgn0261648 FlyBase Gene Snapshot "spalt major (salm) encodes a zinc finger transcriptional repressor. It mediates most dpp functions during development of the central part of the wing through regulation of the products of kni and ara. The product of salm is required for cell specification during the development of the nervous system, muscle, eye or trachea." FBgn0261649 FlyBase Gene Snapshot tincar (tinc) encodes a transmembrane protein involved in the regulation of the development of ommatidial cells. tinc mRNA expression is negatively regulated by the product of svp in a cardioblast subpopulation. FBgn0261671 FlyBase Gene Snapshot tweek (tweek) encodes a protein involved in the endocytosis of synaptic vesicles. FBgn0261673 FlyBase Gene Snapshot no extended memory (nemy) likely encodes a human cytochrome b561 homolog and is involved in middle-term olfactory associative memory and courtship conditioning memory. FBgn0261674 Alliance "Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including adult head; embryonic/larval dorsal vessel; embryonic/larval pericardial cell; embryonic/larval posterior spiracle; and extraembryonic structure. Orthologous to human LRTM2 (leucine rich repeats and transmembrane domains 2)." FBgn0261675 UniProtKB "Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. (UniProtKB:Q9VRC9)" FBgn0261679 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in organism. Orthologous to human ZNF575 (zinc finger protein 575) and ZNF76 (zinc finger protein 76)." FBgn0261680 Alliance Is expressed in organism. FBgn0261681 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. Is expressed in embryonic proventriculus. FBgn0261682 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0261683 UniProtKB "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:25447994, PubMed:27577095, PubMed:27646273). Has a role in ciliary structure and function (PubMed:27646273). (UniProtKB:M9MRD5)" FBgn0261697 UniProtKB "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27646273). Has a role in ciliary structure and function (PubMed:27646273). (UniProtKB:Q9VMH0)" FBgn0261698 FlyBase Gene Snapshot slowpoke 2 (SLO2) encodes a channel involved in potassium ion transmembrane transport. FBgn0261703 FlyBase Gene Snapshot germ cell-expressed bHLH-PAS (gce) encodes a bHLH-PAS domain transcription factor paralogous to the product of Met. It is a receptor for the sesquiterpenoid juvenile hormone. FBgn0261705 Alliance Enables sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to several human genes including KLF8 (KLF transcription factor 8). FBgn0261709 Alliance Is expressed in organism. FBgn0261710 FlyBase Gene Snapshot no circadian temperature entrainment (nocte) encodes a protein involved in temperature compensation of the circadian clock. FBgn0261714 FlyBase Gene Snapshot Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. FBgn0261722 FlyBase Gene Snapshot flower (fwe) encodes a transmembrane protein with different isoforms expressed in 'loser' and in 'winner' cells to mediate win/lose decisions in cell competition and neuronal culling during development and ageing. FBgn0261723 FlyBase Gene Snapshot "Dbx (Dbx) encodes a homedomain transcription factor expressed in distinct subsets of interneurons. It helps control the differentiation of these neurons, which tend to extend short axons and be GABA-ergic, via cross-repressive interactions with the products of exex and eve. The roles of the product of Dbx include neuronal specification and differentiation." FBgn0261740 Alliance "Involved in regulation of development, heterochronic." FBgn0261786 FlyBase Gene Snapshot minus (mi) encodes a protein that can bind to the product of CycE and the SCF-ago ubiquitin-ligase complex. Minus regulates the turnover of the product of CycE and cell proliferation. FBgn0261787 UniProtKB "Cooperates with Rab11 and fwd/PI4K to mediate the flow of membrane through the Golgi, which is required to support cleavage furrow ingression, therefore promoting cytokinesis in male meiotic cells. (UniProtKB:Q9VIL0)" FBgn0261788 FlyBase Gene Snapshot "Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis." FBgn0261789 FlyBase Gene Snapshot "Small ribonucleoprotein particle protein SmD2 (SmD2) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD1. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing." FBgn0261790 FlyBase Gene Snapshot "Small ribonucleoprotein particle protein SmE (SmE) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmF and SNRPG." FBgn0261791 FlyBase Gene Snapshot Small nuclear ribonucleoprotein G (SNRPG) encodes a Sm class protein and a common component of pre-mRNA processing U snRNPs. It forms the toroidal core of U snRNPs (Sm core domain) together with 6 related Sm proteins. FBgn0261792 FlyBase Gene Snapshot small ribonucleoprotein particle U1 subunit C (snRNP-U1-C) encodes a U1 snRNA-containing protein that initiates spliceosome assembly by binding to the 5' splice site in pre-mRNA. FBgn0261793 FlyBase Gene Snapshot "TATA box binding protein-related factor 2 (Trf2) encodes a core promoter recognition factor that mediates gene transcription. It contributes to spiracle morphogenesis, pupal development and salivary gland cell death." FBgn0261794 FlyBase Gene Snapshot kazachoc (kcc) encodes a potassium:chloride symporter that contributes to seizure susceptibility. FBgn0261797 FlyBase Gene Snapshot "Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis." FBgn0261799 FlyBase Gene Snapshot "doublesex cognate 73A (dsx-c73A) encodes a secreted cuticle protein present in the epidermis, salivary duct and trachea. The epidermal expression is under the control of the product of ovo." FBgn0261802 Alliance "Enables protein phosphatase 1 binding activity. Predicted to be involved in cell-cell junction organization. Located in lateral plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; epidermis; and ganglia. Orthologous to human AJM1 (apical junction component 1 homolog)." FBgn0261803 Alliance Is expressed in antennal primordium; embryonic antennal sense organ; embryonic/larval dorsal tracheal branch; embryonic/larval tracheal dorsal trunk; and embryonic/larval tracheal section. FBgn0261804 Alliance Predicted to enable metallodipeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. Orthologous to several human genes including DPEP2 (dipeptidase 2). FBgn0261808 FlyBase Gene Snapshot "curled (cu) encodes a NADP/NADPH phosphatase. It is involved in NADP metabolism, mRNA poly(A) tail shortening and response to light. cu mutants has wings curved upward." FBgn0261811 FlyBase Gene Snapshot "pico (pico) encodes an intracellular adapter protein belonging to the MRL family of proteins, which transduce signals from growth factor receptors to changes in the actin cytoskeleton. Its roles include the regulation of growth and cell migration." FBgn0261822 FlyBase Gene Snapshot "Basigin (Bsg) encodes an IgG family glycoprotein that promotes cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. It contributes to photoreceptor cell morphogenesis, sarcomere organization and spermatid development." FBgn0261823 FlyBase Gene Snapshot Additional sex combs (Asx) encodes a chromatin binding protein with deubiquitination activity of the product of His2A. It genetically interacts with Pc and sxc and represses homeotic genes transcription. It contributes to antennal development and embryonic cell cycle. FBgn0261836 FlyBase Gene Snapshot "Muscle-specific protein 300 kDa (Msp300) encodes a Nesprin-like protein that is required for proper positioning of muscle nuclei, mitochondria, and neuromuscular junction." FBgn0261848 Alliance Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). FBgn0261850 FlyBase Gene Snapshot Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. FBgn0261854 FlyBase Gene Snapshot "atypical protein kinase C (aPKC) encodes a member of the conserved Par complex and is asymmetrically localized to the apical cortex, where it phosphorylates and thus excludes the basal determinants encoded by mira and numb. It is involved in neuroblast proliferation and self-renewal." FBgn0261858 Alliance Enables gamma-tubulin binding activity. Involved in gamma-tubulin complex localization. Located in centriole; centrosome; and mitochondrial outer membrane. Part of gamma-tubulin ring complex. Is expressed in gonad and male germline cell. Orthologous to human MZT1 (mitotic spindle organizing protein 1). FBgn0261859 Alliance Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval muscle system; gonad; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Orthologous to several human genes including FRMPD4 (FERM and PDZ domain containing 4). FBgn0261862 FlyBase Gene Snapshot withered (whd) encodes a carnitine O-palmitoyltransferase involved in oxidative stress. FBgn0261863 Alliance Involved in larval foraging behavior. FBgn0261864 Alliance Involved in larval foraging behavior. FBgn0261865 Alliance Involved in larval foraging behavior. FBgn0261866 Alliance Involved in larval foraging behavior. FBgn0261867 Alliance Involved in larval foraging behavior. FBgn0261868 Alliance Involved in larval foraging behavior. FBgn0261869 Alliance Involved in larval foraging behavior. FBgn0261871 Alliance Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. FBgn0261872 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in intracellular calcium ion homeostasis. Predicted to be active in perinuclear region of cytoplasm. Is expressed in several structures, including central brain primordium; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein)." FBgn0261873 FlyBase Gene Snapshot stardust (sdt) encodes membrane-associated guanylate kinase (MAGUK) protein involved in the maintenance of apico-basal cell polarity and the organization of zonula adherens. FBgn0261874 Alliance Involved in sleep. FBgn0261875 Alliance Involved in sleep. FBgn0261876 Alliance Involved in sleep. FBgn0261877 Alliance Involved in sleep. FBgn0261878 Alliance Involved in sleep. FBgn0261879 Alliance Involved in sleep. FBgn0261881 UniProtKB "Required for regulating the establishment of planar cell polarity in the wing (PubMed:32750048). Forms a complex with Bdbt which likely functions in the regulation of planar polarity by promoting the activity of Dco during planar polarity establishment (PubMed:32750048). Within the complex, probably functions to stabilize Bdbt, while Bdbt directly promotes Dco activity in regulating phosphorylation of core proteins such as dsh, and asymmetric localization (PubMed:32750048). (UniProtKB:Q9V3Y0)" FBgn0261885 FlyBase Gene Snapshot osa (osa) encodes a subunit of the BAP chromatin remodeling complex. It antagonizes Wnt target gene expression and limits the self-renewal of neural and intestinal stem cells. FBgn0261928 Alliance Predicted to enable GTPase activator activity. Is expressed in adult head. Orthologous to human TBC1D30 (TBC1 domain family member 30). FBgn0261929 FlyBase Gene Snapshot "5-hydroxytryptamine (serotonin) receptor 2B (5-HT2B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7." FBgn0261930 FlyBase Gene Snapshot "ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages." FBgn0261931 Alliance "Predicted to enable ubiquitin protein ligase activity. Involved in protein K63-linked ubiquitination. Is active in cytosol. Orthologous to several human genes including HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2)." FBgn0261933 FlyBase Gene Snapshot "Small ribonucleoprotein particle protein SmD1 (SmD1) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD2. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing." FBgn0261934 FlyBase Gene Snapshot dikar (dikar) encodes a protein involved in long-term memory. FBgn0261938 Alliance "Enables 3'-5'-RNA exonuclease activity and DNA primase activity. Involved in DNA replication, synthesis of primer and DNA synthesis involved in mitochondrial DNA replication. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial DNA-directed RNA polymerase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial)." FBgn0261952 Alliance Involved in amnioserosa formation; dorsal/ventral pattern formation; and positive regulation of BMP signaling pathway. Predicted to be active in extracellular space. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). FBgn0261953 FlyBase Gene Snapshot "Transcription factor AP-2 (TfAP-2) encodes a transcription factor with essential roles in leg, proboscis, and central nervous system development. It mediates Notch signaling in the developing tarsus." FBgn0261954 FlyBase Gene Snapshot "enhanced adult sensory threshold (east) encodes a ubiquitous protein localized to an extrachromosomal domain of the nucleus. It is involved in chemosensory behavior, chromosome segregation during cell division, cell survival and muscle development." FBgn0261955 UniProtKB Plays a role in controlling neuronal activity and seizure susceptibility. (UniProtKB:Q9W401) FBgn0261963 Interactive Fly T-box transcription factors that participate in cardiac fate specificity - regulates wing development by repressing wingless and hedgehog FBgn0261973 FlyBase Gene Snapshot C/D box small nucleolar RNA 63a (snoRNA:CD63a) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A549 in 18SrRNA:CR45838. FBgn0261974 FlyBase Gene Snapshot C/D box small nucleolar RNA 63b (snoRNA:CD63b) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A549 in 18SrRNA:CR45838. FBgn0261976 UniProtKB The GINS complex plays an essential role in the initiation of DNA replication. (UniProtKB:Q9VQY9) FBgn0261983 FlyBase Gene Snapshot lethal (2) giant discs 1 (l(2)gd1) encodes a cytosolic protein conserved in Metazoa. It is involved in the transport of proteins such as signaling receptors through the endosomal pathway. It interacts with the ESCRT-III core component encoded by shrb and is probably required for its full activity. FBgn0261984 FlyBase Gene Snapshot "Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation." FBgn0261985 FlyBase Gene Snapshot Protein tyrosine phosphatase Meg (Ptpmeg) encodes a tyrosine phosphatase that interacts with the product of Eps-15. It negatively regulates border cell migration during oogenesis. It also inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis. FBgn0261986 FlyBase Gene Snapshot Ras association domain family member 8 (RASSF8) encodes a member of the N-terminal RASSF protein family. It localises with the product of ASPP at the adherens junctions of epithelial cells where it promotes junction stability by repressing Src activity via C-terminal Src kinase. FBgn0261987 FlyBase Gene Snapshot "Peroxinectin-like (Pxt) encodes a cycloxygenase-like enzyme that contributes to the synthesis of prostaglandins. Prostaglandins activate G protein-coupled receptor signaling. Its roles include oogenesis, sperm individualization, morphogenesis, nucleolar structure, temporal control of gene expression, and regulation of gene amplification." FBgn0261988 FlyBase Gene Snapshot "G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity." FBgn0261995 Alliance Predicted to enable UDP-sugar diphosphatase activity. Predicted to be involved in nucleoside phosphate metabolic process and ribose phosphate metabolic process. Is expressed in adult head and adult heart. Orthologous to human NUDT14 (nudix hydrolase 14). FBgn0261996 Alliance "Predicted to enable hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides and metal ion binding activity. Orthologous to human NUDT14 (nudix hydrolase 14)." FBgn0261998 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0261999 Alliance Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in T-tubule and sarcoplasmic reticulum. Is expressed in adult head; adult heart; embryonic/larval muscle system; and spermatozoon. Human ortholog(s) of this gene implicated in retinal cone dystrophy 4. Orthologous to human CACNA2D4 (calcium voltage-gated channel auxiliary subunit alpha2delta 4). FBgn0262000 Alliance Is expressed in adult head and adult heart. FBgn0262005 Alliance Involved in sexual reproduction. Predicted to be located in extracellular space. FBgn0262007 Alliance "Predicted to enable hexose transmembrane transporter activity. Involved in defense response to virus. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; and embryonic/larval midgut primordium." FBgn0262008 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. FBgn0262009 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in testis. FBgn0262010 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Is expressed in testis. FBgn0262017 Alliance Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. FBgn0262018 UniProtKB Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (UniProtKB:Q9VJB6) FBgn0262026 Alliance "Involved in retrograde axonal transport. Is expressed in several structures, including embryonic anal pad; embryonic/larval muscle cell; embryonic/larval muscle system; gut section; and posterior midgut primordium." FBgn0262029 FlyBase Gene Snapshot "dachs (dachs) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts." FBgn0262057 FlyBase Gene Snapshot "Serpin 77Ba (Spn77Ba) encodes a serine protease inhibitor of the serpin family. It functions in the trachea in a protease cascade required for melanization, a host defense reaction against microbial pathogens." FBgn0262073 Alliance Involved in response to anesthetic. FBgn0262074 Alliance Involved in response to anesthetic. FBgn0262075 Alliance Involved in response to anesthetic. FBgn0262076 Alliance Involved in response to anesthetic. FBgn0262077 Alliance Involved in response to anesthetic. FBgn0262078 Alliance Involved in response to anesthetic. FBgn0262081 FlyBase Gene Snapshot C-terminal Src kinase (Csk) encodes a cytoplasmic tyrosine kinase that acts as a tumor suppressor through Src pathway inibition as well as a mediator of the activity of the product of Egfr. FBgn0262100 Alliance Enables phospholipid binding activity. Involved in membrane bending. Is active in membrane. Is expressed in adult head. FBgn0262103 Interactive Fly cooperates with Mondo-Mlx to maintain organismal sugar tolerance through the regulation of NADPH/NADP+ redox balance - expression in clock neurons-morning oscillators (M cells) regulates male sex drive - feeding and fasting signals converge on the LKB1-SIK3 pathway to regulate lipid metabolism -regulates growth through the Hippo signalling pathway FBgn0262105 Alliance Involved in regulation of gene expression and spermatogenesis. FBgn0262106 Alliance Involved in spermatogenesis. FBgn0262109 Alliance "Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; epithelium; and optic lobe neuroepithelial cell." FBgn0262111 FlyBase Gene Snapshot forked (f) encodes a protein involved in assembly of actin filament bundles. FBgn0262112 FlyBase Gene Snapshot shroud (sro) encodes a short-chain dehydrogenase/reductase that is essential for ecdysone biosynthesis. It is hypothesized to work in the conversion of 7-dehydrocholesterol to 5beta-ketodiol. FBgn0262114 FlyBase Gene Snapshot "Ran-binding protein M (RanBPM) encodes a protein involved in cell adhesion that regulates the shape, size, and organization of the germline stem cell niche in the ovary." FBgn0262115 UniProtKB Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity). (UniProtKB:Q8SYS7) FBgn0262116 FlyBase Gene Snapshot "Ribonuclease kappa (RNASEK) encodes a protein involved in clathrin-mediated endocytosis of large cargo, such as viruses." FBgn0262117 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (UniProtKB:Q7PLS8)" FBgn0262123 Alliance Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to be active in cytoplasm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 15. Orthologous to human CCDC40 (coiled-coil domain 40 molecular ruler complex subunit). FBgn0262124 UniProtKB Probable metal transporter (By similarity). Acts downstream of PRL-1 and protects the nervous system against olfactory carbon dioxide stimulation (PubMed:31404830). (UniProtKB:A0A0B7P9G0) FBgn0262125 FlyBase Gene Snapshot Secretory 23 (Sec23) encodes a COPII vesicle-coating component that functions in vesicle transport from the ER to the Golgi apparatus. It is involved in cell polarity maintenance and extracellular matrix secretion. FBgn0262126 FlyBase Gene Snapshot "Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation." FBgn0262127 UniProtKB "Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway. (UniProtKB:Q9VFG8)" FBgn0262139 FlyBase Gene Snapshot "trachealess (trh) encodes a bHLH-PAS nuclear transcription factor required for the formation of the tube of the salivary duct, trachea and filzkorper. It is also required for expression of all tracheal genes." FBgn0262146 FlyBase Gene Snapshot "Metallothionein E (MtnE) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnE shows the least specificity towards binding metal ions." FBgn0262160 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval fat body; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335)." FBgn0262166 UniProtKB "Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1) (PubMed:20436459, PubMed:30258054, PubMed:30639226, PubMed:36180891). Mediates bisymmetric organization of the PR-DUB complex and is involved in association with nucleosomes to mediate deubiquitination (PubMed:30258054). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). Required to maintain the transcriptionally repressive state of homeotic genes throughout development (PubMed:20436459). The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20436459). Polycomb group (PcG) protein (PubMed:17717194). (UniProtKB:Q7K5N4)" FBgn0262167 FlyBase Gene Snapshot "anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility." FBgn0262169 FlyBase Gene Snapshot "magu (magu) encodes a secreted protein that binds glypicans and regulates BMP signaling. It contributes to the regulation of growth and patterning of the wing, germ-line stem cell maintenance and adult life span." FBgn0262172 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. FBgn0262174 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262177 Alliance Involved in negative regulation of locomotor rhythm. Is expressed in embryonic/larval hindgut and embryonic/larval salivary gland. FBgn0262178 Alliance Involved in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria and negative regulation of peptidoglycan recognition protein signaling pathway. Predicted to be part of RISC complex. FBgn0262185 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262200 Alliance "Involved in several processes, including negative regulation of Toll signaling pathway; negative regulation of innate immune response; and regulation of feeding behavior." FBgn0262205 Alliance Involved in imaginal disc-derived wing morphogenesis and negative regulation of smoothened signaling pathway. Predicted to be part of RISC complex. Is expressed in wing disc. FBgn0262210 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262214 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262215 Alliance Involved in border follicle cell migration. FBgn0262220 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262233 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262235 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262239 Alliance "Involved in several processes, including negative regulation of Toll signaling pathway; negative regulation of innate immune response; and regulation of feeding behavior." FBgn0262243 Alliance Involved in immune response and regulation of feeding behavior. FBgn0262249 Alliance Involved in negative regulation of signal transduction and regulation of synaptic assembly at neuromuscular junction. Is expressed in adult gut. FBgn0262252 Alliance Involved in cellular response to ecdysone and histoblast morphogenesis. Predicted to be part of RISC complex. Is expressed in histoblast nest. FBgn0262256 Alliance "Involved in several processes, including negative regulation of Toll signaling pathway; negative regulation of innate immune response; and regulation of feeding behavior." FBgn0262263 Alliance Involved in germ cell development and positive regulation of locomotion. Predicted to be part of RISC complex. FBgn0262266 Alliance Involved in negative regulation of stress granule assembly and response to heat. Acts upstream of with a negative effect on memory. Is expressed in embryonic/larval brain; eye disc; and photoreceptor. FBgn0262279 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262290 Interactive Fly "directly inhibits Ubx activity in vivo - ectopic expression induces a classical homeotic mutant phenotype, the transformation of halteres into wings" FBgn0262291 Alliance Involved in regulation of defense response to virus. Is expressed in embryonic/larval brain and eye disc. FBgn0262300 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262319 Alliance "Involved in negative regulation of glutamate secretion, neurotransmission. Is expressed in several structures, including adult brain; adult head; adult mushroom body; embryonic/larval central nervous system; and synaptic neuropil domain. Used to study neurodegenerative disease." FBgn0262321 Alliance "Involved in several processes, including negative regulation of innate immune response; negative regulation of signal transduction; and regulation of feeding behavior. Is expressed in embryonic/larval central nervous system and organism." FBgn0262323 Alliance "Involved in several processes, including negative regulation of G2/M transition of mitotic cell cycle; negative regulation of activin receptor signaling pathway; and negative regulation of macromolecule metabolic process. Is expressed in embryonic/larval brain; embryonic/larval optic lobe; eye disc; and larval ventral nerve cord." FBgn0262330 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. FBgn0262331 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262333 Alliance Involved in immune response and regulation of feeding behavior. FBgn0262353 Alliance Is expressed in embryonic midgut chamber and embryonic/larval midgut. FBgn0262357 Alliance Predicted to enable galactose binding activity. Predicted to be involved in induction of bacterial agglutination. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC6A (C-type lectin domain containing 6A); CLEC4D (C-type lectin domain family 4 member D); and CLEC4E (C-type lectin domain family 4 member E). FBgn0262360 Alliance Predicted to be involved in positive regulation of transcription by RNA polymerase II. FBgn0262366 Alliance Predicted to be part of Cul2-RING ubiquitin ligase complex. FBgn0262367 Alliance Involved in negative regulation of apoptotic process. Predicted to be part of RISC complex. Is expressed in embryonic/larval brain and larval ventral nerve cord. FBgn0262368 Alliance Involved in determination of adult lifespan and wing disc dorsal/ventral pattern formation. Predicted to be part of RISC complex. FBgn0262369 Alliance Involved in wing disc development. FBgn0262370 Interactive Fly "microRNA, post-transcriptional gene regulation - promotes neuroepithelial cell-to-neuroblast transition in the optic lobe by targeting downstream Notch effectors - contributes to the control of wing growth - facilitates Notch-induced tumourigenesis - regulates Tramtrack69 in a developmental switch in follicle cells" FBgn0262371 Alliance "Involved in several processes, including chaeta development; positive regulation of locomotor rhythm; and regulation of branching morphogenesis of a nerve. Is expressed in adult CNS glial cell; adult brain; external sensory organ precursor cell; mechanosensory sensory organ; and organism subdivision." FBgn0262372 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in dorsal ectoderm and organism. FBgn0262373 Interactive Fly "a microRNA that regulates maternal-to-zygotic transition, muscle-tendon attachments, production of sensory bristles and wing development" FBgn0262374 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262376 Alliance Involved in positive regulation of synaptic assembly at neuromuscular junction. Predicted to be part of RISC complex. Is expressed in embryonic/larval central nervous system and organism. Used to study fragile X syndrome. FBgn0262377 Alliance Involved in negative regulation of apoptotic process and negative regulation of translational initiation. Predicted to be part of RISC complex. Is expressed in embryonic epidermis; embryonic hindgut; and organism. FBgn0262378 Alliance "Involved in several processes, including negative regulation of Toll signaling pathway; negative regulation of defense response; and startle response. Predicted to be part of RISC complex." FBgn0262380 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in dorsal ectoderm and organism. FBgn0262381 Alliance "Involved in regulation of circadian sleep/wake cycle, sleep. Predicted to be part of RISC complex." FBgn0262383 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262385 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in organism. FBgn0262386 Alliance Involved in male germ-line stem cell population maintenance; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and wing disc development. Predicted to be part of RISC complex. FBgn0262387 Alliance Involved in cellular response to hypoxia. Predicted to be part of RISC complex. FBgn0262388 Alliance Involved in larval somatic muscle development and neuroblast differentiation. Is expressed in embryonic cardioblast; embryonic/larval somatic muscle cell; and somatic mesoderm. FBgn0262389 Alliance Involved in miRNA-mediated post-transcriptional gene silencing and regulation of cholinergic synaptic transmission. Predicted to be part of RISC complex. FBgn0262391 Interactive Fly a highly conserved microRNA that is expressed in the female germline and has assumed control over multiple steps in oogenesis and early embryogenesis FBgn0262393 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262395 Alliance Involved in positive regulation of smoothened signaling pathway. Is expressed in embryonic foregut; embryonic hindgut; embryonic/larval peripheral nervous system; embryonic/larval salivary gland; and posterior midgut primordium. FBgn0262396 Alliance Involved in negative regulation of double-strand break repair. Predicted to be part of RISC complex. Is expressed in adult gut. FBgn0262397 Alliance Involved in negative regulation of apoptotic process and negative regulation of translational initiation. Predicted to be part of RISC complex. Is expressed in embryonic/larval brain and larval ventral nerve cord. FBgn0262398 Interactive Fly "post-transcriptional regulation, gene silencing by miRNA, negative regulation of synaptic transmission; dendrite morphogenesis, neuroblast proliferation" FBgn0262400 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262401 Alliance Involved in regulation of establishment of blood-brain barrier. Is expressed in embryonic/larval brain. FBgn0262402 Alliance "Involved in several processes, including cellular response to nitric oxide; negative regulation of canonical Wnt signaling pathway; and response to nicotine." FBgn0262403 Alliance Involved in energy homeostasis; female germ-line stem cell asymmetric division; and negative regulation of apoptotic process. FBgn0262404 Alliance Involved in negative regulation of neuron differentiation; regulation of locomotor rhythm; and regulation of signal transduction. FBgn0262405 Alliance Involved in positive regulation of epidermal growth factor receptor signaling pathway. FBgn0262406 Interactive Fly encodes an RNA species involved in translational silencing of target mRNAs - let-7-to-miR-125 miRNA switch regulates neuronal integrity and lifespan in Drosophila FBgn0262407 Alliance Involved in negative regulation of apoptotic process; peptidoglycan recognition protein signaling pathway; and post-transcriptional regulation of gene expression. FBgn0262408 Alliance Involved in negative regulation of smoothened signaling pathway. Predicted to be part of RISC complex. Is expressed in dorsal ectoderm and organism. FBgn0262409 Alliance Involved in negative regulation of muscle organ development. Predicted to be part of RISC complex. Is expressed in embryonic foregut; embryonic hindgut; embryonic/larval peripheral nervous system; embryonic/larval salivary gland; and posterior midgut primordium. FBgn0262410 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in dorsal ectoderm and organism. FBgn0262411 Alliance "Involved in several processes, including cuticle pattern formation; positive regulation of circadian sleep/wake cycle, sleep; and regulation of olfactory learning. Is expressed in embryonic brain; larval ventral nerve cord; and mesothoracic leg." FBgn0262413 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262414 Alliance Is expressed in dorsal ectoderm and organism. FBgn0262415 Alliance Involved in regulation of synaptic assembly at neuromuscular junction. Predicted to be part of RISC complex. FBgn0262416 Alliance Involved in positive regulation of gliogenesis and wing disc development. Is expressed in anterior endoderm; embryonic foregut; embryonic hindgut; and organism. FBgn0262417 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in mesoderm and visceral muscle primordium. FBgn0262418 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in dorsal ectoderm and organism. FBgn0262419 Interactive Fly "microRNA that carries out post-transcriptional gene regulation, modulates rCGG repeat-mediated neurodegeneration and the pathogenesis of FXTAS neurodegenerative disorder by post-transcriptionally regulating the expression of specific mRNAs involved in the disease" FBgn0262420 Alliance Involved in chorion-containing eggshell pattern formation and eggshell chorion gene amplification. Predicted to be part of RISC complex. Is expressed in follicle cell. FBgn0262421 Alliance Involved in negative regulation of apoptotic process. Predicted to be part of RISC complex. Is expressed in embryonic/larval brain; embryonic/larval gut; embryonic/larval somatic muscle cell; and larval ventral nerve cord. FBgn0262424 Alliance "Involved in negative regulation of smoothened signaling pathway. Predicted to be part of RISC complex. Is expressed in several structures, including anal pad primordium; embryonic primordium of adult hindgut precursor; gut section; larval ventral nerve cord; and posterior midgut primordium." FBgn0262425 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262426 Alliance Involved in positive regulation of smoothened signaling pathway. Is expressed in embryonic foregut; embryonic hindgut; embryonic/larval peripheral nervous system; embryonic/larval salivary gland; and posterior midgut primordium. FBgn0262428 Alliance Involved in dendrite regeneration. FBgn0262429 Alliance Involved in negative regulation of apoptotic process. Predicted to be part of RISC complex. FBgn0262430 Alliance Involved in germ cell development and negative regulation of cellular senescence. FBgn0262431 Alliance Involved in miRNA-mediated gene silencing by inhibition of translation. FBgn0262432 Interactive Fly "acts through U-shaped to activate PI3K, thereby promoting fat cell growth cell-autonomously and enhancing growth non-cell-autonomously - antagonizes Wg signaling in part by directly targeting wntless, a gene required for Wg secretion" FBgn0262433 Alliance "Involved in lipid droplet formation; photoreceptor cell maintenance; and regulation of locomotor rhythm. Predicted to be part of RISC complex. Is expressed in several structures, including adult brain; adult mushroom body; adult optic lobe; photoreceptor neurons; and synaptic neuropil domain." FBgn0262434 Alliance Involved in cellular response to gamma radiation; miRNA-mediated post-transcriptional gene silencing; and negative regulation of apoptotic process. Predicted to be part of RISC complex. Is expressed in intercalary segment. FBgn0262436 Alliance "Involved in several processes, including cellular response to nitric oxide; negative regulation of canonical Wnt signaling pathway; and response to nicotine. Is expressed in several structures, including brain; embryonic/larval oenocyte; gonad; organism subdivision; and somatic cell of ovariole. Used to study alcohol use disorder." FBgn0262437 Alliance Involved in open tracheal system development and response to hypoxia. Is active in terminal bouton. Is expressed in organism. FBgn0262438 Alliance Involved in miRNA-mediated gene silencing by inhibition of translation. FBgn0262440 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0262441 Alliance "Involved in several processes, including cellular response to nitric oxide; negative regulation of canonical Wnt signaling pathway; and response to nicotine. Used to study alcohol use disorder." FBgn0262443 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in dorsal ectoderm and organism. FBgn0262445 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in organism. FBgn0262446 Alliance Involved in positive regulation of insulin receptor signaling pathway. FBgn0262447 Interactive Fly "a cell death suppressor - regulates fat metabolism - regulates insulin production and metabolism through its target, sugarbabe" FBgn0262448 Alliance "Involved in several processes, including locomotor rhythm; negative regulation of cell differentiation; and regulation of signal transduction. Is expressed in several structures, including adult brain; anterior spiracle primordium; embryonic head sensory system; embryonic/larval peripheral nervous system; and external sensory organ precursor cell." FBgn0262449 Alliance Involved in negative regulation of apoptotic process and negative regulation of translational initiation. Predicted to be part of RISC complex. Is expressed in embryonic epidermis and embryonic hindgut. FBgn0262450 Alliance "Involved in several processes, including cellular response to nitric oxide; negative regulation of canonical Wnt signaling pathway; and response to nicotine." FBgn0262451 Interactive Fly "a 21 nucleotide microRNA that promotes tissue growth, stimulates cell proliferation and prevents apoptosis - controls of type I and type II central brain neuroblast proliferation" FBgn0262452 Alliance Involved in negative regulation of cellular senescence and negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of RISC complex. FBgn0262453 Alliance Involved in male germ-line stem cell population maintenance; miRNA-mediated post-transcriptional gene silencing; and negative regulation of peptidoglycan recognition protein signaling pathway. FBgn0262455 Alliance "Enables mRNA base-pairing translational repressor activity. Involved in several processes, including imaginal disc-derived wing vein morphogenesis; regulation of Notch signaling pathway; and regulation of cardiac muscle cell differentiation. Predicted to be part of RISC complex. Is expressed in several structures, including heart primordium; mesoderm; muscle cell; somatic muscle; and visceral mesoderm derivative. Used to study dilated cardiomyopathy." FBgn0262456 Alliance "Involved in several processes, including germ-line stem-cell niche homeostasis; miRNA-mediated gene silencing by mRNA destabilization; and positive regulation of Notch signaling pathway. Acts upstream of with a positive effect on determination of adult lifespan. Predicted to be part of RISC complex. Is expressed in central nervous system and organism." FBgn0262458 Alliance "Involved in several processes, including cellular response to nutrient; intestinal stem cell homeostasis; and regulation of signal transduction. Predicted to be part of RISC complex." FBgn0262459 Alliance Involved in miRNA-mediated post-transcriptional gene silencing; neuromuscular junction development; and regulation of synapse organization. Is expressed in adult abdomen; adult brain; adult head; and adult thorax. FBgn0262460 Alliance Involved in negative regulation of apoptotic process and negative regulation of translational initiation. Predicted to be part of RISC complex. Is expressed in embryonic epidermis and embryonic hindgut. FBgn0262461 Alliance Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of synaptic assembly at neuromuscular junction. Is expressed in embryonic/larval brain and larval ventral nerve cord. FBgn0262462 Interactive Fly "directly inhibits Ubx activity in vivo - ectopic expression induces a classical homeotic mutant phenotype, the transformation of halteres into wings" FBgn0262463 Alliance Involved in cellular response to ecdysone. Predicted to be part of RISC complex. Is expressed in central nervous system and organism. FBgn0262464 Alliance Involved in negative regulation of apoptotic process. Predicted to be part of RISC complex. Is expressed in dorsal ectoderm and organism. FBgn0262467 FlyBase Gene Snapshot Synthesis of cytochrome c oxidase (Scox) encodes a protein involved in cytochrome complex assembly and regulation of ATP biosynthesis. FBgn0262473 FlyBase Gene Snapshot Toll (Tl) encodes a transmembrane receptor that activates the Tl intracellular signaling pathway upon binding the ligand encoded by spz. It is involved in dorso-ventral embryonic patterning and immunity. FBgn0262475 Alliance "Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splice site recognition; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; mesoderm; and posterior endoderm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF1 (CUGBP Elav-like family member 1) and CELF2 (CUGBP Elav-like family member 2)." FBgn0262476 Alliance "Predicted to enable neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid transport; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including CNS glial cell; adult head; embryonic central brain neurons; embryonic head sensory system; and ganglia. Human ortholog(s) of this gene implicated in Hartnup disease and autosomal recessive intellectual developmental disorder 48. Orthologous to several human genes including SLC6A15 (solute carrier family 6 member 15) and SLC6A17 (solute carrier family 6 member 17)." FBgn0262477 FlyBase Gene Snapshot "Forkhead box P (FoxP) encodes a transcription factor expressed in the nervous system. It is involved in locomotion, operant self-learning and courtship behavior." FBgn0262483 FlyBase Gene Snapshot RIM-binding protein (Rbp) encodes an active zone protein involved in neuromuscular synaptic transmission and presynaptic active zone organization. FBgn0262508 Alliance Is expressed in adult head; adult heart; and embryonic/larval muscle system. FBgn0262509 FlyBase Gene Snapshot neuromusculin (nrm) encodes a protein involved in synaptic target recognition. FBgn0262512 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). (UniProtKB:Q24583)" FBgn0262513 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c)." FBgn0262514 Alliance "Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b)." FBgn0262515 UniProtKB "Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. (UniProtKB:Q7JR49)" FBgn0262516 FlyBase Gene Snapshot "Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation." FBgn0262517 FlyBase Gene Snapshot Listerin E3 ubiquitin protein ligase 1 (Ltn1) encodes an enzyme involved in ribosome quality control for co-translational degradation of the 'nonstop' proteins. It associates with the 60S ribosome subunit and ubiquitylates the peptidyl-tRNA so the nascent peptide can be degraded by the proteasome. FBgn0262518 FlyBase Gene Snapshot "Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes." FBgn0262519 FlyBase Gene Snapshot "Mi-2 (Mi-2) encodes a nuclear ATP-dependent nucleosome remodeler of the CHD family. It associates with active chromatin and utilizes the energy of ATP hydrolysis to move nucleosomes along DNA. It is required for repression of cell type-specific genes, full activation of heat shock genes and regulates higher order chromatin structure of polytene chromosomes." FBgn0262520 Alliance Involved in regulation of programmed cell death. FBgn0262521 Alliance Involved in regulation of programmed cell death. FBgn0262523 Alliance Involved in regulation of programmed cell death. FBgn0262524 FlyBase Gene Snapshot "verrocchio (ver) encodes a member of the terminin complex, which prevents telomere fusions. It is required for telomere maintenance." FBgn0262527 FlyBase Gene Snapshot "non-specific lethal 1 (nsl1) encodes a non-catalytic subunit of the NSL histone H4 acetyltransferase complex, and is involved in muscle development, oogenesis and regulation of endocytosis." FBgn0262534 Alliance Orthologous to human HARBI1 (harbinger transposase derived 1). FBgn0262535 Alliance Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. FBgn0262559 FlyBase Gene Snapshot "Malate dehydrogenase 2 (Mdh2) encodes a mitochondrial enzyme that reversibly catalyzes the oxidation of S-malate to oxaloacetate using the reduction of NAD+ to NADH. It is involved in the tricarboxylic acid (TCA) cycle, gluconeogenesis and the malate-aspartate shuttle." FBgn0262560 FlyBase Gene Snapshot wicked (wcd) encodes a member of the U3 snoRNP complex required for pre-ribosomal RNA maturation. It is involved in stem cell maintenance and function via regulation of cell size by ribosome synthesis. FBgn0262562 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of Rho protein signal transduction. Is expressed in leg joint; primary tracheal branch; and spermatozoon. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17). FBgn0262570 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0262579 FlyBase Gene Snapshot Sterile alpha and Armadillo motif (Sarm) encodes an intracellular signaling molecule that is required for execution of a pro-degenerative pathway after axotomy. FBgn0262582 FlyBase Gene Snapshot "capicua (cic) encodes an HMG-box family transcriptional repressor that serves as a general sensor of RTK signaling. cic-dependent gene silencing is alleviated by phosphorylation mediated by the product of rl, which causes the translocation of the product of cic from the nucleus to the cytoplasm. It governs gene expression in diverse processes including cell proliferation and specification." FBgn0262587 Alliance Predicted to be involved in proteolysis. FBgn0262588 Alliance Predicted to be involved in proteolysis. FBgn0262593 FlyBase Gene Snapshot "Shaker cognate b (Shab) encodes a member of the Sh family and the structural alpha subunit of a delayed rectifier K[+] channel (Kv2). The product of Shab channel functions to regulate excitability in neurons and muscles, and transmitter release." FBgn0262594 Alliance Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0262595 Alliance Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in extracellular region. FBgn0262598 FlyBase Gene Snapshot mitoshell (mtsh) encodes a protein with a bromodomain-related region. It is required during spermatogenesis for proper temporal coordination of meiotic divisions with the morphogenetic events that usually follow meiosis. FBgn0262599 Alliance Is expressed in dorsal pharyngeal muscle cell. FBgn0262601 FlyBase Gene Snapshot "Small ribonucleoprotein particle protein SmB (SmB) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD3. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing." FBgn0262614 FlyBase Gene Snapshot "polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two." FBgn0262617 Interactive Fly serine/threonine kinase that biochemically and genetically interacts with the cochaperone Starvin in the autophagic clearance of protein aggregates in larval muscles - Filamin/Cheerio is a target of NUAK kinase activity and abnormally accumulates upon loss of the Starvin-Hsc70-4 complex FBgn0262619 UniProtKB "DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (UniProtKB:Q9W1H4)" FBgn0262620 Alliance Is expressed in wing disc. FBgn0262621 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0262624 Alliance "Involved in sensory perception of sound. Predicted to be active in plasma membrane. Is expressed in several structures, including dorsal ectoderm anlage; embryonic anal pad; embryonic hypopharynx; embryonic large intestine; and gut section. Used to study autosomal recessive nonsyndromic deafness 67. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 67. Orthologous to several human genes including LHFPL4 (LHFPL tetraspan subfamily member 4)." FBgn0262636 FlyBase Gene Snapshot "datilografo (dati) encodes a conserved zinc finger transcription factor required for the differentiation of neurons in the ventral nerve cord and the brain. In adult brains, the product of dati is required in cholinergic neurons to generate the decisions of accepting or rejecting male courtship." FBgn0262647 UniProtKB Functions as a component of the nuclear pore complex (NPC) (PubMed:19197064). Involved in poly(A)+ RNA transport (By similarity). Required for nuclear import of Mad (PubMed:20547758). May play a role in double strand break DNA repair (PubMed:26502056). Essential for nephrocyte development (PubMed:30910934). (UniProtKB:Q9VKJ3) FBgn0262656 FlyBase Gene Snapshot "Myc (Myc) encodes a transcription factor that is homologous to vertebrate Myc proto-oncogenes. It contributes to cell growth, cell competition and regenerative proliferation." FBgn0262685 Alliance Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in migraine. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). FBgn0262699 FlyBase Gene Snapshot fizzy-related (fzr) encodes a protein that binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase. FBgn0262708 Alliance Involved in adult somatic muscle development and flight. FBgn0262709 Alliance Involved in adult somatic muscle development and flight. FBgn0262710 Alliance Involved in adult somatic muscle development and flight. FBgn0262711 Alliance Involved in adult somatic muscle development and flight. FBgn0262712 Alliance Involved in adult somatic muscle development and flight. FBgn0262713 Alliance Involved in adult somatic muscle development and flight. FBgn0262714 Alliance "Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Sin3-type complex. Is expressed in several structures, including adult brain cell body rind; embryonic/larval brain; epithelial tube; gland; and ring gland. Orthologous to human SAP130 (Sin3A associated protein 130)." FBgn0262716 UniProtKB "Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline (PubMed:25739458). (UniProtKB:P32392)" FBgn0262717 FlyBase Gene Snapshot "Skeletor (Skel) encodes a protein that localizes to chromosomes at interphase and interacts directly with the product of Chro to mark regions of open chromatin. It forms part of a matrix embedding the microtubule spindle apparatus, which is important for normal cell cycle progression and functions as a spatial regulator of cell cycle factors." FBgn0262719 Alliance Is expressed in spermatozoon. Orthologous to human TTC28 (tetratricopeptide repeat domain 28). FBgn0262721 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0262728 FlyBase Gene Snapshot "Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2 (Pal2) encodes one of two related lyases (the other is encoded by Pal1) involved in alpha-amidation of neuropeptides, thereby promoting neuropeptide potency and stability." FBgn0262730 Alliance Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to several human genes including TMEM132A (transmembrane protein 132A); TMEM132B (transmembrane protein 132B); and TMEM132C (transmembrane protein 132C). FBgn0262732 FlyBase Gene Snapshot "multiprotein bridging factor 1 (mbf1) encodes a transcriptional co-activator that bridges between sequence-specific transcriptional regulators and the product of Tbp. Under stress, the product of mbf1 in the cytoplasm can translocate into the nucleus and serve as a co-activator to induce stress-reponse genes." FBgn0262733 FlyBase Gene Snapshot "Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A." FBgn0262734 Alliance Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). FBgn0262736 FlyBase Gene Snapshot "Vacuolar H[+] ATPase 16kD subunit 1 (Vha16-1) encodes the proteolipid component of V-ATPase, which is a multi-functional channel protein. It contributes to vesicle-membrane fusion, hydrophilic molecule transport and intercellular communication." FBgn0262737 FlyBase Gene Snapshot mushroom-body expressed (mub) encodes a protein involved in thermosensory behavior and regulation of alternative mRNA splicing. FBgn0262738 UniProtKB "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). (UniProtKB:P13217)" FBgn0262739 FlyBase Gene Snapshot "Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both." FBgn0262740 UniProtKB "Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge. (UniProtKB:Q9VYY9)" FBgn0262743 FlyBase Gene Snapshot "Female sterile (2) Ketel (Fs(2)Ket) encodes a protein that functions in nuclear protein import, formation of the spindle apparatus and nuclear envelope assembly. It is also involved in biogenesis of the mitochondria." FBgn0262750 Alliance Predicted to be part of chromatin. FBgn0262751 Alliance Predicted to be part of chromatin. FBgn0262761 Alliance Predicted to be part of chromatin. FBgn0262782 FlyBase Gene Snapshot Malate dehydrogenase 1 (Mdh1) encodes a cytosolic enzyme that reversibly catalyzes the oxidation of S-malate to oxaloacetate using the reduction of NAD+ to NADH. It is involved in gluconeogenesis and the malate-aspartate shuttle. FBgn0262794 Alliance Involved in response to wounding. FBgn0262801 Alliance "Enables serine hydrolase activity. Predicted to be involved in signal peptide processing. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and mesoderm. Orthologous to several human genes including SEC11A (SEC11 homolog A, signal peptidase complex subunit)." FBgn0262823 UniProtKB "Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing. (UniProtKB:A0A0B4K753)" FBgn0262842 Alliance "Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of mitochondrial respiratory chain complex III. Predicted to be active in mitochondrial inner membrane." FBgn0262854 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0262858 Alliance Predicted to enable metal ion binding activity. Predicted to be involved in cellular detoxification. FBgn0262866 FlyBase Gene Snapshot "Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning." FBgn0262867 Alliance "Predicted to be involved in cognition. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; epithelium; and head epidermis primordium. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4)." FBgn0262869 Interactive Fly a GPI-anchored membrane protein with four GDNF family receptor-like domains - regulates oogenesis and male fertility - expressed in the central and peripheral nervous systems FBgn0262870 UniProtKB May have serine protease inhibitor activity (Probable). Might play a role in the glial-neuronal signaling pathway that is important in establishing the electrical properties of axonal membranes (PubMed:10037607). (UniProtKB:M9PE65) FBgn0262871 FlyBase Gene Snapshot lute (lute) encodes a protein involved in neurogenesis. FBgn0262872 UniProtKB "Required for kinesin-mediated axonal transport of mitochondria to nerve terminals (PubMed:12495622, PubMed:16717129, PubMed:16887820). The oocyte acquires the majority of its mitochondria by competitive bidirectional transport along microtubules mediated by the Milton adapter. Mitochondria enter the young oocyte en mass from interconnected germ cells to generate the large aggregate known as the Balbiani body (PubMed:16887820). Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129). (UniProtKB:Q960V3)" FBgn0262873 Alliance Predicted to be located in extracellular space. FBgn0262881 Alliance Involved in response to wounding. Located in extracellular region. FBgn0262937 Alliance "Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including imaginal disc-derived wing vein specification; positive regulation of protein ubiquitination; and regulation of Rab protein signal transduction. Located in apical part of cell and endocytic vesicle. Is expressed in organism and spermatozoon. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1)." FBgn0262952 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (UniProtKB:P18931) FBgn0262954 Alliance "Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K)." FBgn0262955 FlyBase Gene Snapshot RNA polymerase II subunit B (Polr2B) encodes a protein thought to be present in all RNA pol II complexes. FBgn0262965 Alliance "Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval fat body; embryonic/larval midgut; gland; and nephrocyte." FBgn0262966 Alliance Predicted to be located in membrane. FBgn0262971 Alliance Involved in spermatogenesis. FBgn0262975 FlyBase Gene Snapshot "cap-n-collar (cnc) encodes cap-n-collar (cnc) encodes a transcription factor that interacts with the product of Keap1 to regulate the activation of genes by oxidative stress. The cnc-encoded product also contributes to mRNA localization mediated by microtubules, dendrite morphogenesis and intestinal stem cell homeostasis." FBgn0262976 Alliance Located in polytene chromosome interband and polytene chromosome puff. Is expressed in organism. FBgn0262986 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0262987 Alliance Predicted to enable chromatin binding activity. Predicted to be involved in mitotic G2 DNA damage checkpoint signaling. Predicted to be active in nucleus. Orthologous to human MRNIP (MRN complex interacting protein). FBgn0262998 Alliance Involved in spermatogenesis. FBgn0263005 Alliance Predicted to enable N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Orthologous to several human genes including CHPF2 (chondroitin polymerizing factor 2). FBgn0263006 FlyBase Gene Snapshot Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. FBgn0263018 Alliance "Predicted to enable U6atac snRNA binding activity and pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U4atac snRNP." FBgn0263019 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in cephalic furrow; embryonic/larval peripheral nervous system; and organism. FBgn0263024 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0263025 Alliance Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. Located in cytoplasm. Is expressed in spermatozoon. Orthologous to human HSPBAP1 (HSPB1 associated protein 1). FBgn0263027 Alliance Orthologous to human DNAJC28 (DnaJ heat shock protein family (Hsp40) member C28). FBgn0263029 Alliance Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to several human genes including GNG2 (G protein subunit gamma 2). FBgn0263030 Alliance Is expressed in embryonic/larval salivary gland and embryonic/larval salivary gland body. FBgn0263031 Alliance Predicted to enable zinc ion binding activity. Is expressed in embryonic/larval salivary gland and embryonic/larval salivary gland body. FBgn0263032 Alliance Predicted to be involved in cristae formation. Predicted to be part of MICOS complex. Predicted to be active in mitochondrial crista junction. FBgn0263033 Alliance Predicted to be involved in cristae formation. Predicted to be part of MICOS complex. Predicted to be active in mitochondrial crista junction. Is expressed in spermatozoon. FBgn0263038 Alliance "Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell adhesion and extracellular matrix organization. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including adult brain; embryonic dorsal epidermis; embryonic head epidermis; embryonic proventriculus inner layer; and gut section." FBgn0263040 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0263041 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0263047 Alliance Predicted to enable DNA binding activity. FBgn0263048 Alliance Predicted to enable NAD binding activity and protein homodimerization activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase (FAD) complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). FBgn0263049 Alliance Involved in cellular response to ecdysone; mushroom body development; and negative regulation of gene expression. Predicted to be part of RISC complex. Is expressed in alpha/beta Kenyon cell; mushroom body; synaptic neuropil domain; and synaptic neuropil subdomain. FBgn0263050 Alliance Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome. Is expressed in organism. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to several human genes including PLD3 (phospholipase D family member 3) and PLD4 (phospholipase D family member 4). FBgn0263051 Alliance Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 10. Orthologous to human NDUFAF2 (NADH:ubiquinone oxidoreductase complex assembly factor 2). FBgn0263072 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon." FBgn0263076 Alliance Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in adult brain cell body rind and adult gnathal ganglion. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human KIF12 (kinesin family member 12). FBgn0263077 Alliance Involved in filopodium assembly. Located in cytosol. Colocalizes with actin cytoskeleton. Is expressed in adult head. FBgn0263079 Alliance Orthologous to human CCDC170 (coiled-coil domain containing 170). FBgn0263082 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0263084 Alliance Predicted to enable chromatin binding activity. Predicted to be involved in chromosome organization. Predicted to be located in nucleus. Predicted to be part of chromatin. FBgn0263088 Alliance Involved in spermatogenesis. FBgn0263102 FlyBase Gene Snapshot pipsqueak (psq) encodes a transcription factor that regulates chromatin silencing. It mediates the interaction of Polycomb group (Pc-G) members with Pc-G response elements. FBgn0263106 FlyBase Gene Snapshot DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. FBgn0263107 Interactive Fly miR-263a - mutants exhibit defects in the peripheral nervous system - regulates ENaC to maintain osmotic and intestinal stem cell homeostasis FBgn0263108 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval nervous system; and ganglia." FBgn0263109 Alliance "Predicted to be active in extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic hypopharynx; epithelial tube; and gut section. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1)." FBgn0263110 Alliance "Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytosol and membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and germline cell. Human ortholog(s) of this gene implicated in gray platelet syndrome. Orthologous to several human genes including NBEAL1 (neurobeachin like 1)." FBgn0263111 FlyBase Gene Snapshot "cacophony (cac) encodes the primary structural subunit of a voltage-gated calcium channel, which is located at presynaptic active zones. It functions in evoked neurotransmitter release at neuromuscular synapses. It contributes to male courtship behavior and a wide range of neurophysiological processes." FBgn0263112 FlyBase Gene Snapshot Mitf (Mitf) encodes a b-HLH-Zip transcription factor that regulates basic cellular processes in part by controlling the expression of the vacuolar (H[+])-ATPase subunits. FBgn0263113 UniProtKB "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity). (UniProtKB:A1ZAV1)" FBgn0263116 FlyBase Gene Snapshot "5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7." FBgn0263117 Alliance Orthologous to human SAMD5 (sterile alpha motif domain containing 5). FBgn0263120 Interactive Fly regulates fatty acid metabolism - modifies the composition of fatty acids and membrane lipid - inhibits neuromuscular junction growth - facilitates Rab11-dependent receptor recycling - regulates axonal transport of synaptic vesicles FBgn0263121 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (UniProtKB:Q9XZJ4)" FBgn0263131 Alliance Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and cAMP biosynthetic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to several human genes including ADCY5 (adenylate cyclase 5). FBgn0263132 FlyBase Gene Snapshot Chitinase 6 (Cht6) encodes an enzyme involved in ecdysis. FBgn0263133 FlyBase Gene Snapshot mitochondrial translation elongation factor G 1 (mEFG1) encodes a mitochondrial elongation factor that catalyzes the translocation of the mRNAs and tRNAs along the ribosomes via GTP hydrolysis. FBgn0263143 FlyBase Gene Snapshot vreteno (vret) encodes a Tudor-domain containing protein required for piRNA biogenesis. vret mutants are sterile due to transposon de-repression. FBgn0263144 FlyBase Gene Snapshot bicoid-interacting protein 3 (bin3) encodes an RNA methyltransferase that adds a 5'-methyl cap to the product of snRNA:7SKa preventing its degradation. It contributes to inhibition of cad mRNA translation in the anterior of the embryo. FBgn0263197 FlyBase Gene Snapshot Patronin (Patronin) encodes a microtubule minus-end binding protein that can promote acentrosomal nucleation of microtubules. Apical localisation of the Patronin product orients microtubules in polarised epithelial cells and in oocytes. FBgn0263198 FlyBase Gene Snapshot "Acinus (Acn) encodes nuclear protein that, together with the products of a Bin1 and RnpS1, forms the ASAP complex that contributes to the regulation of alternative splicing. The Acn protein also functions in basal, starvation-independent autophagy." FBgn0263199 FlyBase Gene Snapshot Galactokinase (Galk) encodes an enzyme that phosphorylates alpha-D-galactose to form alpha-D-galactose 1-phosphate. It is involved in galactose metabolism. FBgn0263200 FlyBase Gene Snapshot Galactose-1-phosphate uridylyltransferase (Galt) encodes an enzyme that synthesizes glucose 1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose 1-phosphate. It is involved in galactose metabolism. FBgn0263201 Alliance Predicted to be involved in RNA processing. Located in Cajal body. FBgn0263216 Alliance "Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic esophagus; embryonic head epidermis; and embryonic hypopharynx." FBgn0263219 FlyBase Gene Snapshot Down syndrome cell adhesion molecule 4 (Dscam4) one of four Dscam paralogs in the D. melanogaster genome. It encodes a homophilic cell adhesion molecule that regulates interactions between dendrites and axons in the visual system. FBgn0263220 FlyBase Gene Snapshot "Hyperkinetic (Hk) encodes a beta-subunit of Sh K[+] channels and modulates its channel function. It is important in regulating action potentials in neurons and muscles, and transmitter release." FBgn0263231 FlyBase Gene Snapshot "belle (bel) encodes a DEAD-box RNA helicase that functions both as positive and negative translation regulator. It is essential for embryo viability and fertility, and is required for the maintenance of male germ-line stem cells." FBgn0263232 Alliance Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in nucleus. Orthologous to human NXF1 (nuclear RNA export factor 1); NXF2 (nuclear RNA export factor 2); and NXF2B (nuclear RNA export factor 2B). FBgn0263233 Alliance Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in centrosome and cytoplasm. Is expressed in chordotonal neurons. FBgn0263234 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0263235 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0263236 Alliance "Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic maxillary sensory complex; embryonic ventral epidermis; and epithelium. Orthologous to human ANPEP (alanyl aminopeptidase, membrane)." FBgn0263237 FlyBase Gene Snapshot "Cyclin-dependent kinase 7 (Cdk7) encodes a serine/threonine protein kinase whose activity depends on the regulatory subunits encoded by CycH and Mat1. This trimeric Cdk complex activates other Cdks by phosphorylation in their T-loop and is called Cdk activating kinase (CAK). CAK can also be part of TFIIH, where the product of Cdk7 phosphorylates different transcription substrates (e.g. CTD of Pol II)." FBgn0263239 FlyBase Gene Snapshot "dendritic arbor reduction 1 (dar1) encodes a transcription factor in the Kruppel-like factor family. It determines the multipolar morphology of neurons by promoting the growth of dendrites (but not axons), in part by controlling the expression of regulators of microtubules and microtubule-based transport." FBgn0263240 FlyBase Gene Snapshot "Corepressor of Pangolin (Coop) encodes a protein that represses gene expression mediated by Wg signaling. It binds to the product of pan preventing the interaction of the products of pan with arm. By antagonizing Wg signaling, it contributes to patterning and cell fate decisions during development." FBgn0263241 UniProtKB "Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. (UniProtKB:Q8IQF1)" FBgn0263251 FlyBase Gene Snapshot variable nurse cells (vnc) encodes a protein involved in histone acetylation and oogenesis. FBgn0263256 Alliance "Is expressed in several structures, including adult fat body; anlage in statu nascendi; antennal anlage; gut section; and somatic precursor cell." FBgn0263257 Alliance "Predicted to enable intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Predicted to be involved in monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Is expressed in several structures, including adult brain cell body rind; adult mushroom body; adult optic lobe; organism subdivision; and synaptic neuropil domain." FBgn0263258 Alliance "Involved in establishment of body hair or bristle planar orientation. Located in apical plasma membrane and muscle tendon junction. Is expressed in several structures, including dorsal epidermis primordium; embryonic epipharynx; embryonic head epidermis; epidermis; and gut section." FBgn0263260 FlyBase Gene Snapshot seele (sel) encodes an endoplasmic reticulum-resident Saposin-like protein. It is involved in dorsal-ventral patterning by contributing to secretion and activation of the protease encoded by ea. FBgn0263261 Alliance Involved in gonad development. FBgn0263262 Alliance Involved in digestive tract mesoderm development and gonad development. FBgn0263263 Alliance Involved in gonad development. FBgn0263264 Alliance Involved in gonad development. FBgn0263265 Alliance Involved in gonad development. FBgn0263266 Alliance Involved in digestive tract mesoderm development and gonad development. FBgn0263267 Alliance Involved in gonad development. FBgn0263268 Alliance Involved in gonad development. FBgn0263278 FlyBase Gene Snapshot "Fic domain-containing protein (Fic) encodes an enzymes that catalyzes the addition of AMP residues to proteins. The products of Fic are located in the endoplasmic reticulum (ER), where they AMPylate the main ER chaperone encoded by Hsc70-3." FBgn0263289 FlyBase Gene Snapshot "scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory." FBgn0263316 FlyBase Gene Snapshot Multidrug resistance protein 4 (Mrp4) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in the response to oxidative stress and hypoxia. FBgn0263321 Alliance Is expressed in adult head. FBgn0263333 Alliance Involved in spermatogenesis. FBgn0263335 Alliance Involved in spermatogenesis. FBgn0263346 Alliance "Predicted to enable microtubule binding activity. Involved in morphogenesis of embryonic epithelium and protein localization to cell-cell junction. Located in zonula adherens. Is expressed in several structures, including adult fat body; embryonic/larval muscle cell; epithelium; gut section; and synaptic neuropil domain." FBgn0263351 FlyBase Gene Snapshot "Adaptor Protein complex 2, mu subunit (AP-2mu) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization." FBgn0263352 FlyBase Gene Snapshot "Upstream of N-ras (Unr) encodes an RNA binding protein that functions as an RNA chaperone and translation regulator. It performs opposing, sex-specific, roles in X-chromosome dosage compensation by regulating lncRNA:roX2 RNA conformation in males and msl-2 mRNA translation in females." FBgn0263353 Alliance Predicted to be involved in regulation of cell differentiation. Predicted to be active in membrane. Is expressed in adult head. FBgn0263354 Alliance Predicted to be involved in protein ubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in spermatozoon. FBgn0263355 Alliance Is expressed in adult head. FBgn0263380 Alliance Involved in target-directed miRNA degradation. Is expressed in organism and yolk nucleus. FBgn0263390 FlyBase Gene Snapshot Na[+]/H[+] hydrogen antiporter 2 (Nha2) encodes a protein involved in the transmembrane transport of potassium. FBgn0263391 FlyBase Gene Snapshot "hu li tai shao (hts) encodes an adducin homolog that is associated with the plasma membrane cytoskeleton, fusome and oocyte ring canals. It has essential functions in muscle, nerve and other tissues, and is required for fertility in males and females." FBgn0263392 UniProtKB "Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936838, PubMed:30078725). N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression (PubMed:25936838). Promotes differentiation of early germ cells in ovary (PubMed:25936838). Contributes to neuronal morphology, development, and function in the brain (PubMed:30078725). By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation (PubMed:30078725). Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:25936838). (UniProtKB:M9NEY8)" FBgn0263395 FlyBase Gene Snapshot "happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways." FBgn0263396 FlyBase Gene Snapshot squid (sqd) encodes a member of the hnRNPA family of RNA binding proteins. It is involved in the localization and translational regulation of grk mRNA in oogenesis. FBgn0263397 FlyBase Gene Snapshot "I[[h]] channel (Ih) encodes a low-threshold, voltage-gated ion channel. It may influence excitatory postsynaptic potential kinetics and integration." FBgn0263398 UniProtKB "(Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body. (UniProtKB:Q9VC99)" FBgn0263413 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0263447 Alliance Is expressed in organism. FBgn0263456 FlyBase Gene Snapshot nervous wreck (nwk) encodes a membrane- and actin cytoskeleton-remodeling protein that localizes to presynaptic periactive zones. It regulates the traffic of synaptic vesicles and synaptic growth-regulating endosomal cargoes such as BMP receptors. FBgn0263465 FlyBase Gene Snapshot C/D box small nucleolar RNA 66 (snoRNA:CD66) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0263467 FlyBase Gene Snapshot C/D box small nucleolar RNA 67 (snoRNA:CD67) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C2744 in 28SrRNA:CR45844. FBgn0263471 Alliance Enables snRNA 2'-O-ribose methylation guide activity. Located in Cajal body. FBgn0263474 Alliance Enables snRNA pseudouridylation guide activity. Predicted to be involved in RNA processing. Located in Cajal body. FBgn0263477 Alliance Enables rRNA pseudouridylation guide activity and snRNA pseudouridylation guide activity. Predicted to be involved in RNA processing. Located in Cajal body. FBgn0263479 Alliance Enables snRNA pseudouridylation guide activity. Predicted to be involved in RNA processing. Located in Cajal body. FBgn0263485 Alliance Enables rRNA pseudouridylation guide activity and snRNA pseudouridylation guide activity. Predicted to be involved in RNA processing. Located in Cajal body. FBgn0263486 Alliance Enables snRNA pseudouridylation guide activity. Predicted to be involved in RNA processing. Located in Cajal body. FBgn0263487 Alliance Located in Cajal body. FBgn0263489 FlyBase Gene Snapshot C/D box small nucleolar RNA 78 (snoRNA:CD78) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A441 in 18SrRNA:CR45838. FBgn0263490 FlyBase Gene Snapshot molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. FBgn0263495 Alliance Involved in spermatogenesis. FBgn0263510 UniProtKB "Chromatin-associated factor that regulates transcription (PubMed:21752937). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I-elongation factor TFIIH (PubMed:29065309). Acts as a regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients (PubMed:29065309). Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts (PubMed:21752937). Not required for female germline stem cell (GSC) maintenance, but necessary to regulate germ cell differentiation and egg chamber development (PubMed:21752937). In female somatic cells, required for follicle stem cell survival and maintenance (PubMed:21752937). (UniProtKB:A1Z8D0)" FBgn0263511 FlyBase Gene Snapshot Visual system homeobox 1 (Vsx1) encodes a transcription factor involved in the development of the visual-system. FBgn0263512 FlyBase Gene Snapshot Visual system homeobox 2 (Vsx2) encodes a transcription factor involved in the development of the visual-system. FBgn0263593 FlyBase Gene Snapshot Lipin (Lpin) encodes a protein that plays a central role in fat body function and energy metabolism. It works as a phosphatidate phosphatase required for normal insulin pathway signaling. FBgn0263594 FlyBase Gene Snapshot lost (lost) encodes a protein that interacts with the RNA-binding protein encoded by rump for posterior localization of mRNAs by diffusion/entrapment during late stages of oogenesis. The identification of the product of lost in various RNP complexes suggests a broad role in RNA metabolism. FBgn0263595 Alliance Is expressed in ectoderm and organism. FBgn0263597 UniProtKB Responsible for physiological and behavioral changes in mated female flies. (UniProtKB:O46201) FBgn0263598 FlyBase Gene Snapshot "Vacuolar H[+] ATPase 68 kDa subunit 2 (Vha68-2) encodes a component of the V1 subunit of the vacuolar ATPase, which acidifies endosomal compartments including the lysosome and influences the activity of several signaling pathways." FBgn0263599 UniProtKB "Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (By similarity). Plays a role in pre-mRNA splicing (By similarity). (UniProtKB:Q9VUV9)" FBgn0263600 UniProtKB "As the catalytic component of the DNA polymerase delta complex, plays a crucial role in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:1360647, PubMed:7907087, PubMed:8415662). Required at the nucleus of rapidly dividing embryonic cells to activate genome replication during the earliest cell cycles (PubMed:31100062). Likely to require the presence of accessory proteins PolD2 and PolD3 for full activity (PubMed:31100062). (UniProtKB:P54358)" FBgn0263601 FlyBase Gene Snapshot mind bomb 1 (mib1) encodes an E3 ubiquitin ligase that regulates Notch signaling by influencing the endocytosis of the products of Delta and Ser. FBgn0263602 FlyBase Gene Snapshot Taspase 1 (Tasp1) encodes a threonine-type endopeptidase involved in spermatogenesis and the defense response to Gram-negative bacteria. FBgn0263603 FlyBase Gene Snapshot Zinc-finger protein at 72D (Zn72D) encodes a protein involved in the splicing of the mle transcript. FBgn0263605 Alliance "Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in organism. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component)." FBgn0263606 FlyBase Gene Snapshot Heat shock protein cognate 20 (Hsc20) encodes a mitochondrial chaperone that facilitates iron sulfur cluster assembly or transfer from the product of IscU to other scaffold proteins. Hsc20 is required for larval growth and cellular iron sensing. FBgn0263607 Alliance Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Predicted to be active in vacuole. Is expressed in adult head. Orthologous to human GGH (gamma-glutamyl hydrolase). FBgn0263608 Alliance Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Predicted to be active in vacuole. Orthologous to human GGH (gamma-glutamyl hydrolase). FBgn0263617 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in embryonic/larval central nervous system; embryonic/larval salivary gland; eye disc; and larval ventral nerve cord. FBgn0263619 Alliance Involved in germ-line stem-cell niche homeostasis. FBgn0263659 Alliance "Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval epidermis; embryonic/larval fat body; embryonic/larval salivary gland; and eye disc." FBgn0263660 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0263662 Alliance Involved in cellular response to starvation and positive regulation of insulin receptor signaling pathway. FBgn0263667 FlyBase Gene Snapshot Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. FBgn0263697 UniProtKB "Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. (UniProtKB:Q9V6U8)" FBgn0263705 FlyBase Gene Snapshot "Myosin 10A (Myo10A) encodes an unconventional myosin of the MyTH-FERM superclass that traffics sensory, cytoskeletal, and adhesion cargos. It is required during dorsal closure for proper epithelial alignment and for zippering and fusion of the two epithelial sheets." FBgn0263706 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Is expressed in adepithelial cell of leg disc and adult head. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to several human genes including ARHGEF10 (Rho guanine nucleotide exchange factor 10). FBgn0263738 UniProtKB GCN5-independent Polr2D complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription. (UniProtKB:Q7KSD8) FBgn0263740 UniProtKB "As a subunit of eukaryotic initiation factor 2 eIF2, involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B. (UniProtKB:Q24208)" FBgn0263745 Alliance Is expressed in organism. FBgn0263747 Alliance Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). FBgn0263748 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0263755 UniProtKB "Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation. (UniProtKB:P45975)" FBgn0263757 UniProtKB DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G. (UniProtKB:Q9VEA5) FBgn0263772 Alliance "Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor); MYT1 (myelin transcription factor 1); and MYT1L (myelin transcription factor 1 like)." FBgn0263773 Alliance "Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; anterior endoderm anlage; embryonic anal pad; and epithelium." FBgn0263776 Alliance "Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in vacuolar membrane. Is expressed in several structures, including adult head; amnioserosa; amnioserosa primordium; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3)." FBgn0263780 Alliance Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP10 (dipeptidyl peptidase like 10) and DPP6 (dipeptidyl peptidase like 6). FBgn0263782 FlyBase Gene Snapshot "HMG Coenzyme A reductase (Hmgcr) encodes the rate-controlling enzyme of the mevalonate pathway that produces isoprenoids. It is required during heart tube formation, molting regulation and primordial germ cell migration." FBgn0263829 Alliance "Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm." FBgn0263830 Alliance "Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult fat body. Orthologous to human DHRS11 (dehydrogenase/reductase 11)." FBgn0263831 FlyBase Gene Snapshot "XPG-like endonuclease (Gen) encodes a nuclease that cuts Holliday junctions, flaps, and replication forks during DNA and replication fork repair." FBgn0263832 FlyBase Gene Snapshot "Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation." FBgn0263842 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. FBgn0263846 Alliance Located in Z disc. Is expressed in adult head. FBgn0263850 Alliance Predicted to enable RNA binding activity and nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and telomere tethering at nuclear periphery. Predicted to be part of nuclear pore cytoplasmic filaments. FBgn0263851 FlyBase Gene Snapshot C/D box small nucleolar RNA 68 (snoRNA:CD68) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of G475 in 18SrRNA:CR45838. FBgn0263852 UniProtKB "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Probably as part of the N-glycosylation pathway, plays a role in the regulation of tissue growth and apoptosis (PubMed:27693235). (UniProtKB:Q9VLM5)" FBgn0263855 FlyBase Gene Snapshot "Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females." FBgn0263859 Alliance Involved in memory. FBgn0263860 Alliance Involved in associative learning and memory. FBgn0263863 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; gut section; head epidermis primordium; and mesoderm. Orthologous to human MRPL45 (mitochondrial ribosomal protein L45)." FBgn0263864 FlyBase Gene Snapshot Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex. FBgn0263873 FlyBase Gene Snapshot "Neuron navigator (Nav) encodes a cytoskeletal protein that positively regulates F-actin-mediated axonal growth by relaying the non-canonical RacGTPase-Slingshot-Cofilin pathway. It also mediates immune deficiency signaling pathway, which activates the product of Rel." FBgn0263911 Alliance "Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion." FBgn0263916 FlyBase Gene Snapshot Equilibrative nucleoside transporter 2 (Ent2) encodes a member of the equilibrative nucleoside transporter family and represents a primary plasma membrane equilibrative transporter. It is involved in stress signaling and adenosin recycling. FBgn0263929 FlyBase Gene Snapshot javelin-like (jvl) encodes a microtubule associated protein whose roles include actin and microtubule organization during oocyte development and bristle growth. FBgn0263930 FlyBase Gene Snapshot "division abnormally delayed (dally) encodes a core protein of heparan sulfate proteoglycans of the glypican family. It acts as a co-receptor for growth factors and morphogens, such as the products of dpp, wg, hh, upd1 and FGFs, affecting signaling and distribution of these ligands. The roles of the product of dally include wing development and germline stem cell maintenance." FBgn0263933 FlyBase Gene Snapshot "ebi (ebi) encodes a nuclear-localized protein that regulates Egfr, Notch and Wg signaling pathways. ebi encoded product contributes to multiple processes including wing growth and eye development as well as regulation of transcription and innate immune response." FBgn0263934 FlyBase Gene Snapshot espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons. FBgn0263968 FlyBase Gene Snapshot no-on-and-no-off transient C (nonC) encodes a phosphatidylinositol 3-kinase-related kinase. It functions in the nonsense-mediated mRNA decay (NMD) pathway by phosphorylation of the core NMD regulator encoded by Upf1. FBgn0263973 FlyBase Gene Snapshot javelin (jv) encodes an actin associated protein with roles in actin organization during bristle growth. FBgn0263974 FlyBase Gene Snapshot qin (qin) is a piRNA pathway gene that encodes a protein involved in posttranscriptional gene silencing. FBgn0263977 FlyBase Gene Snapshot Translocase of the inner mitochondrial membrane 17b (Tim17b) encodes a small subunit of the mitochondrial inner membrane translocase complex. It is strictly required for the delivery of proteins to the mitochondrial matrix. FBgn0263979 FlyBase Gene Snapshot "Chromatin assembly factor 1, p55 subunit (Caf1-55) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle." FBgn0263980 Alliance Enables calcium channel regulator activity. Involved in calcium ion transmembrane transport; locomotion; and positive regulation of cell size. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC (SH3 and cysteine rich domain); STAC2 (SH3 and cysteine rich domain 2); and STAC3 (SH3 and cysteine rich domain 3). FBgn0263986 FlyBase Gene Snapshot "cardinal (cd) encodes a phenoxazinone synthetase involved in the kynurenine pathway. It contributes to ommochrome biosynthesis, neuron death and siRNA-mediated gene silencing." FBgn0263987 Alliance "Enables JUN kinase binding activity. Involved in several processes, including dorsal appendage formation; follicle cell of egg chamber development; and positive regulation of signal transduction. Is active in cytoplasmic side of mitochondrial outer membrane. Colocalizes with Golgi apparatus. Is expressed in several structures, including adult head; adult mushroom body; embryonic/larval midgut primordium; embryonic/larval somatic muscle cell; and mesoderm. Orthologous to human AKAP1 (A-kinase anchoring protein 1)." FBgn0263988 FlyBase Gene Snapshot "Dynein intermediate chain at 61B (Dic61B) encodes an axonemal dynein intermediate chain protein expressed specifically in male germ cells. It is required for the development and precise assembly of sperm axonemes, thus it is essential for male fertility." FBgn0263994 Alliance Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. FBgn0263995 FlyBase Gene Snapshot "couch potato (cpo) is most strongly expressed in nuclei of the central and peripheral nervous systems and the ring gland, where its product may regulate gene transcription to control complex neurological and neuroendocrine functions. It is required for normal synaptic transmission, climate adaptation, olfaction, diapause and behavioral responses." FBgn0263996 Alliance Is expressed in organism. FBgn0263997 Alliance Located in nucleoplasm. Is expressed in adult brain cell body rind. FBgn0263998 FlyBase Gene Snapshot "Activated Cdc42 kinase-like (Ack-like) encodes a non-receptor tyrosine kinase that participates in signaling by the small GTPase encoded by Cdc42. It is involved in embryonic dorsal closure, an epithelial morphogenetic event." FBgn0263999 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. FBgn0264000 Alliance Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission; modulation of chemical synaptic transmission; and monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of ionotropic glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in adult brain; adult head; and embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). FBgn0264001 FlyBase Gene Snapshot bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression. FBgn0264002 FlyBase Gene Snapshot Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. FBgn0264005 UniProtKB Transcription factor involved in specification of neuronal cell types. (UniProtKB:Q9VEI9) FBgn0264006 FlyBase Gene Snapshot "dyschronic (dysc) encodes a protein that regulates the localization of the calcium-activated potassium channel encoded by slo. The product of dysc impacts circadian locomotor patterns, synaptic morphology, active zone structure, and both spontaneous and evoked neurotransmitter release." FBgn0264075 UniProtKB Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation. (UniProtKB:O15945) FBgn0264077 Alliance Predicted to enable calcium ion binding activity and unfolded protein binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; peripheral nervous system; and presumptive embryonic/larval central nervous system. Orthologous to human CLGN (calmegin) and CANX (calnexin). FBgn0264078 FlyBase Gene Snapshot Flotillin 2 (Flo2) encodes encodes a scaffold protein that contributes to the anti-parasitoid immune response and the secretion and spreading of the ligands encoded by wg and hh. FBgn0264084 Alliance Involved in spermatogenesis. FBgn0264086 Alliance Is expressed in spermatozoon. FBgn0264087 UniProtKB "Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. (UniProtKB:Q8IPH9)" FBgn0264089 FlyBase Gene Snapshot "slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells." FBgn0264253 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermatheca. FBgn0264270 FlyBase Gene Snapshot "Sex lethal (Sxl) encodes an RNA-binding protein, member of the RNA recognition motif (RRM) family. It is a master-feminizing switch contributing to all aspects of sexual dimorphism." FBgn0264272 FlyBase Gene Snapshot "multiple wing hairs (mwh) encodes the most downstream member of the fz/stan planar cell polarity pathway. It binds to the sides of F-actin polymers, inhibits actin polymerization and bundles F-actin. It accumulates on the proximal side of wing cells prior to hair initiation and then in the growing hair." FBgn0264273 FlyBase Gene Snapshot "Semaphorin 2b (Sema2b) encodes a member of the Semaphorins family, which are membrane and secreted short-range signaling proteins. The product of Sema2b contributes to the regulation of axon and dendrite guidance as well as cell-matrix adhesion." FBgn0264291 FlyBase Gene Snapshot Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. FBgn0264294 FlyBase Gene Snapshot "Cytochrome b5 (Cyt-b5) encodes a microsomal cytochrome b5 which is a small hemoprotein that participates in electron transfer in multiple biochemical reactions and pathways, including the metabolism of endogenous and xenobiotic compounds." FBgn0264297 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1). FBgn0264298 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1). FBgn0264299 Alliance Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1). FBgn0264302 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section." FBgn0264303 Alliance "Is expressed in several structures, including dorsal epidermis primordium; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section." FBgn0264305 Alliance Predicted to enable lipid binding activity. Located in endomembrane system. Is expressed in adult head. Orthologous to human TEX2 (testis expressed 2). FBgn0264307 UniProtKB "RNA-binding protein involved in translational regulation and required for long-term memory (PubMed:28525754, PubMed:29105522). Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:24830287, PubMed:26095367, PubMed:26638074, PubMed:32165583). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074, PubMed:32165583). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074, PubMed:32165583). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Plays a role in synapse formation and morphology at neuromuscular junctions by modulating the translation of the tumor suppressor brat (PubMed:29105522). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287). (UniProtKB:Q9VSR3)" FBgn0264308 Alliance Involved in regulation of sensory perception. Predicted to be active in membrane. Is expressed in adult head. FBgn0264324 FlyBase Gene Snapshot sponge (spg) encodes a DOCK family RhoGEF involved in nervous system development and regulation of signaling pathways. FBgn0264325 FlyBase Gene Snapshot "Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis." FBgn0264326 FlyBase Gene Snapshot "DNA polymerase epsilon subunit 1 (PolE1) encodes the large subunit of DNA pol epsilon, an essential DNA polymerase participating with DNA pol alpha and DNA pol delta in cellular DNA replication. The C-terminal and N-terminal regions of the products of PolE1 have differential requirements in mitotic and endo-replicating cells." FBgn0264339 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1E. Orthologous to human GPR158 (G protein-coupled receptor 158) and GPR179 (G protein-coupled receptor 179). FBgn0264341 Alliance Predicted to enable carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Orthologous to human KLRC1 (killer cell lectin like receptor C1); KLRC2 (killer cell lectin like receptor C2); and KLRD1 (killer cell lectin like receptor D1). FBgn0264342 Alliance Predicted to be active in membrane. FBgn0264344 Alliance "Is expressed in several structures, including endoderm anlage; foregut anlage in statu nascendi; head mesoderm anlage; mesoderm anlage; and posterior ectoderm anlage." FBgn0264346 Alliance Involved in spermatogenesis. FBgn0264357 FlyBase Gene Snapshot "SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation." FBgn0264384 Alliance Is expressed in embryonic hindgut; embryonic midgut chamber; embryonic proventriculus; embryonic/larval visceral muscle cell; and organism. FBgn0264386 FlyBase Gene Snapshot Ca[2+]-channel protein alpha[[1]] subunit T (Ca-alpha1T) encodes an alpha 1 subunit of a T-type like voltage gated calcium channel. It mediates a low voltage activated transient calcium current in antennal lobe projection neurons and wing motoneurons that is sensitive to amiloride. FBgn0264389 FlyBase Gene Snapshot opossum (opm) encodes a p24 protein that contributes to the secretion of Wnt ligands. FBgn0264430 Alliance Involved in spermatogenesis. FBgn0264434 Alliance Involved in spermatogenesis. FBgn0264437 Alliance Involved in defense response to insect. FBgn0264439 Alliance "Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Is expressed in several structures, including embryonic/larval central nervous system; gland; imaginal disc; larval insulin secreting cell of pars intercerebralis; and larval ventral nerve cord." FBgn0264442 FlyBase Gene Snapshot "abrupt (ab) encodes a transcription factor that negatively regulates ecdysone signaling, as it binds to the product of tai. It regulates animal survival, organogenesis and multiple tissue morphogenesis, epithelial cell fate, cellular sexual identity, neuron differentiation and neuronal identity switch, cell migration, oncogenesis and germline differentiation. In many cell types, the product of ab is post-transcriptionally repressed by the steroid-induced miRNA let-7." FBgn0264443 Alliance "Is expressed in several structures, including anal pad primordium; embryonic anal pad; embryonic dorsal epidermis; embryonic ventral epidermis; and gut section." FBgn0264444 Alliance Involved in spermatogenesis. FBgn0264449 Alliance "Predicted to be located in cytoskeleton. Is expressed in spermatozoon. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2)." FBgn0264488 Alliance Predicted to enable chitin binding activity. Predicted to be located in extracellular region. FBgn0264489 Alliance Predicted to enable microtubule binding activity. Involved in mesoderm development. Predicted to be active in cytoplasm. Is expressed in adult heart. FBgn0264490 FlyBase Gene Snapshot Ecdysone-induced protein 93F (Eip93F) encodes a DNA binding protein that plays an important role as an adult determinant during fly metamorphosis. FBgn0264491 FlyBase Gene Snapshot "held out wings (how) encodes an RNA-binding protein highly expressed in the mesoderm and tendon cells. It is spliced into two isoforms: how(L) and how(S). how(L) induces RNA destabilization, whereas How(S) stabilizes the RNA targets." FBgn0264492 UniProtKB Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. (UniProtKB:P08181) FBgn0264493 FlyBase Gene Snapshot roadkill (rdx) encodes a protein that functions as a substrate recognition component of Cul3-based E3 ubiquitin ligase complexes. It regulates the Hedgehog signaling pathway by promoting the degradation of the transcription factor encoded by ci. FBgn0264494 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in triglyceride metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; brain; gut section; mushroom body extrinsic neurons; and mushroom body slice. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4)." FBgn0264495 FlyBase Gene Snapshot grappa (gpp) encodes a histone methyltransferase which methylates Lys79 of histone H3. It is required for Polycomb Group (PcG) and Trithorax Group (TrxG) maintenance of gene expression. FBgn0264502 Alliance Predicted to be involved in actin cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in adult head. FBgn0264503 Alliance Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in chromatin remodeling. Predicted to be active in cytoplasm; nucleolus; and nucleoplasm. FBgn0264516 Alliance Predicted to be located in membrane. FBgn0264542 Alliance Predicted to enable phosphotyrosine residue binding activity. Orthologous to several human genes including SHB (SH2 domain containing adaptor protein B); SHE (Src homology 2 domain containing E); and SHF (Src homology 2 domain containing F). FBgn0264556 FlyBase Gene Snapshot Gustatory receptor 39a (Gr39a) encodes a member of the gustatory receptors and is expressed in gustatory sensilla receptor neurons. They detect tastants (non-volatile compounds) via contact chemosensation. FBgn0264560 FlyBase Gene Snapshot gartenzwerg (garz) encodes a guanine nucleotide exchange factor localized to the cis-Golgi apparatus. The roles of the product of garz include membrane and protein trafficking between the Golgi apparatus and the endoplasmic reticulum. It is required for epithelial morphogenesis in the embryo. FBgn0264561 Alliance "Predicted to enable fibroblast growth factor binding activity. Located in Golgi apparatus. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human GLG1 (golgi glycoprotein 1)." FBgn0264562 FlyBase Gene Snapshot "Hormone receptor 4 (Hr4) encodes a nuclear receptor that acts both upstream and downstream of the steroid hormone ecdysone. In the prothoracic gland the product of Hr4 acts as a repressor of ecdysone production. In other tissues, including the salivary gland and the fat body, Hr4 is transcriptionally induced by ecdysone to transduce the effects of the hormone." FBgn0264572 Alliance Is expressed in organism. FBgn0264574 FlyBase Gene Snapshot Glucose transporter 1 (Glut1) encodes a transmembrane protein that transports glucose but not galactose. FBgn0264598 Alliance "Predicted to enable calcium-dependent phospholipid binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including mushroom body development; positive regulation of Rac protein signal transduction; and positive regulation of ruffle assembly. Located in cytoplasm. Is expressed in several structures, including adult antennal lobe; adult head; adult mushroom body; adult optic lobe; and ganglia." FBgn0264605 Alliance Predicted to be located in membrane. FBgn0264606 FlyBase Gene Snapshot Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. FBgn0264607 FlyBase Gene Snapshot "Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions." FBgn0264672 FlyBase Gene Snapshot EGF-domain O-GlcNAc transferase (Eogt) encodes a protein that localizes to the lumen of the endoplasmic reticulum and transfers beta-N-acetylglucosamine (GlcNAc) to extracelluar epidermal growth factor-like domains independently of the product of sxc. The product of Eogt mediates cell adhesion mediated by the product of dpy. FBgn0264691 FlyBase Gene Snapshot Lst8 (Lst8) encodes a conserved TOR-binding protein that may be required for Crtc-dependent regulation of cell growth based on genetic evidence. FBgn0264693 FlyBase Gene Snapshot "ensconsin (ens) encodes a microtubule associated protein required for multiple kinesin-1 functions. It contributes to microtubule motor activity, centrosome separation, nuclear positioning and skeletal muscle development." FBgn0264694 UniProtKB Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl. (UniProtKB:Q9VGP6) FBgn0264695 FlyBase Gene Snapshot Myosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains. FBgn0264707 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Involved in actin cytoskeleton organization; melanotic encapsulation of foreign target; and wound healing. Predicted to be active in cytosol. Is expressed in several structures, including anlage in statu nascendi; ganglia; gut section; head epidermis primordium; and organism subdivision. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9) and SPATA13 (spermatogenesis associated 13)." FBgn0264711 Alliance "Predicted to enable protein heterodimerization activity. Is expressed in several structures, including antennal primordium; central brain primordium; dorsal ectoderm; dorsal epidermis primordium; and head epidermis primordium. Orthologous to human ABTB2 (ankyrin repeat and BTB domain containing 2) and ABTB3 (ankyrin repeat and BTB domain containing 3)." FBgn0264712 Alliance Is expressed in adult head and organism. Orthologous to human UBTD1 (ubiquitin domain containing 1) and UBTD2 (ubiquitin domain containing 2). FBgn0264740 Alliance Predicted to be involved in regulation of lipid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). FBgn0264741 Alliance Predicted to be involved in regulation of lipid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). FBgn0264742 Alliance Predicted to be involved in negative regulation of biosynthetic process. FBgn0264743 Alliance Orthologous to human ANKRD39 (ankyrin repeat domain 39). FBgn0264744 Alliance Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. FBgn0264745 Alliance Is expressed in organism. FBgn0264746 Alliance Predicted to enable SCF ubiquitin ligase complex binding activity. FBgn0264748 Alliance Predicted to enable SCF ubiquitin ligase complex binding activity. FBgn0264750 Alliance Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. FBgn0264751 Alliance Predicted to enable SNAP receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be part of SNARE complex. Orthologous to human VTI1B (vesicle transport through interaction with t-SNAREs 1B). FBgn0264753 FlyBase Gene Snapshot "Rad, Gem/Kir family member 1 (Rgk1) encodes a small GTPase involved in anesthesia-resistant and medium-term memory." FBgn0264776 Alliance Predicted to enable small molecule binding activity. FBgn0264785 FlyBase Gene Snapshot "HIF prolyl hydroxylase (Hph) encodes the prolyl-4 hydroxylase that hydroxylases proline 850a of the product of sima, which is the alpha-subunit of the hypoxia inducible factor (HIF). The product of Hph regulates growth through both independent and dependent mechanisms of the product of sima." FBgn0264810 FlyBase Gene Snapshot Partner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings. FBgn0264815 UniProtKB "Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15673286). Required for male fertility and male mating behavior (PubMed:20551439). (UniProtKB:B7YZV4)" FBgn0264816 Alliance Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to human CCNQ (cyclin Q). FBgn0264817 Alliance Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. FBgn0264848 FlyBase Gene Snapshot "vihar (vih) encodes a protein that belongs to the ubiquitin-conjugating (E2) enzyme family with a direct role in protein ubiquitylation. The product of vih accepts activated ubiquitin from the ubiquitin-activating (E1) enzyme via thioester bond with a conserved catalytic cysteine, then interacts with the APC/C ubiquitin ligase (E3) to directly ubiquitinate target proteins." FBgn0264855 FlyBase Gene Snapshot "Adaptor Protein complex 2, alpha subunit (AP-2alpha) encodes a subunit of the AP-2 adaptor complex. It is required for proper intracellular trafficking and secretion. It contributes to asymmetric cell division, Notch signalling, apico-basal polarity and neurogenesis." FBgn0264857 Interactive Fly "represses the transcription of genes located at its 3' end by a sequence-independent, transcriptional interference mechanism - its repressive activity is limited to the CNS, where, in wild-type embryos, it acts on the Hox gene, abd-A, located immediately downstream of it - a lncRNA, called male-specific abdominal, is required for the development of the secondary cells of the Drosophila male accessory gland" FBgn0264875 Alliance Predicted to enable triplet codon-amino acid adaptor activity. FBgn0264885 Alliance Is expressed in testis. FBgn0264894 Alliance Predicted to enable MAP-kinase scaffold activity. Is expressed in embryonic epipharynx; embryonic hypopharynx; embryonic/larval somatic muscle cell; and spermatozoon. FBgn0264895 FlyBase Gene Snapshot Rap GTPase activating protein 1 (RapGAP1) encodes a small G protein that mediates the activation of ERK signaling via the kinase encoded by tor. FBgn0264907 Alliance Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A15 (solute carrier family 22 member 15). FBgn0264908 FlyBase Gene Snapshot pH-sensitive chloride channel 1 (pHCl-1) encodes a protein involved in chloride transmembrane transport. FBgn0264922 FlyBase Gene Snapshot "Small ubiquitin like modifier (Sumo) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis." FBgn0264953 UniProtKB "Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:22343891, PubMed:22343900). Plays a major role in nociception (response to strong or painful touch) (PubMed:22343891). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors (PubMed:32649914). During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:32649914). Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness (PubMed:32649914). (UniProtKB:M9MSG8)" FBgn0264954 FlyBase Gene Snapshot forkhead domain 3F (fd3F) encodes a trancription factor that contributes to the specialization of mechanosensory cilium. FBgn0264959 FlyBase Gene Snapshot "Src oncogene at 42A (Src42A) encodes the none-receptor tyrosine kinase regulating cell proliferation, cell adhesion and morphogenetic processes including dorsal closure, tracheal tube size control and germ band elongation. It is regulated by both inhibitory and activating tyrosine phosphorylation." FBgn0264962 FlyBase Gene Snapshot Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation. FBgn0264975 FlyBase Gene Snapshot "Neuroglian (Nrg) encodes an immunoglobulin domain-containing cell adhesion molecule that mediates cell-cell adhesion by forming homo- or heterophilic interactions. The long isoform of the product of Nrg is neuron specific and plays roles in neurite outgrowth, axon guidance and synapse formation. The short isoform of the product of Nrg contributes to the formation of septate junctions in epithelial cells." FBgn0264978 UniProtKB Non-vital for development. (UniProtKB:Q24179) FBgn0264979 Alliance Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in embryonic large intestine and organism. Orthologous to human PLA1A (phospholipase A1 member A). FBgn0264987 Alliance Involved in stress response to metal ion. FBgn0265001 Alliance Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. FBgn0265002 Alliance Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. FBgn0265003 FlyBase Gene Snapshot klaroid (koi) encodes a protein involved in double-strand break repair and nuclear migration. FBgn0265011 Alliance "Enables serine-type peptidase activity. Involved in liquid clearance, open tracheal system. Located in apical plasma membrane and extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic ventral epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase)." FBgn0265042 FlyBase Gene Snapshot Inwardly rectifying potassium channel 1 (Irk1) encodes a K[+] channel involved in transepithelial ion transport in the renal tubule and in regulating excitability of the LNv subset of circadian pacemaker neurons. FBgn0265045 FlyBase Gene Snapshot "Stretchin-Mlck (Strn-Mlck) encodes a complex locus producing many large protein isoforms, which likely regulate cytoskeletal dynamics in muscles. A shorter isoform is specifically expressed in indirect flight muscle, localizes to the thick filament and is required to prevent flight muscle hypercontraction. Strn-Mlck mutants cannot fly and show flight muscle atrophy." FBgn0265047 FlyBase Gene Snapshot flagrante delicto Y (FDY) is a gene inserted in the Y chromosome originated from a duplication of vig2. FBgn0265048 FlyBase Gene Snapshot crossveinless d (cv-d) encodes the sole Drosophila member of an insect vitellogenin-like lipoprotein family. It can bind lipids and members of the BMP protein family. Loss of cv-d produces viable flies with disrupted BMP signaling in the developing wing. FBgn0265052 FlyBase Gene Snapshot "Sulfotransferase 3 (St3) encodes an enzyme involved in sulfation, xenobiotic metabolism and the defense response to bacteria." FBgn0265082 Alliance "Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Rac protein signal transduction. Predicted to be located in cytoskeleton. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; embryonic/larval muscle cell; and visceral muscle primordium. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to human FRMD7 (FERM domain containing 7)." FBgn0265083 Alliance Predicted to be involved in mitochondrial respiratory chain complex assembly. Predicted to be active in mitochondrial intermembrane space. Orthologous to human COA4 (cytochrome c oxidase assembly factor 4 homolog). FBgn0265084 Alliance Is expressed in adult head. FBgn0265089 FlyBase Gene Snapshot "eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability." FBgn0265101 FlyBase Gene Snapshot suppressor-of-G2-allele-of-skp1 (Sgt1) encodes a protein required for the stability of the kinase encoded by polo and has a role in centrosome maturation and function. FBgn0265102 FlyBase Gene Snapshot Outer segment 1 (Oseg1) encodes a protein required for ciliogenesis. FBgn0265104 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0265137 FlyBase Gene Snapshot Serpin 42Da (Spn42Da) encodes an endopeptidase inhibitor involved in hormone processing regulation. FBgn0265138 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (UniProtKB:P58952)" FBgn0265139 UniProtKB "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates. (UniProtKB:Q9W594)" FBgn0265140 FlyBase Gene Snapshot Meltrin (Meltrin) encodes an ADAM protein that belongs to the metzincin superfamily of metalloproteases. It is regulated by the homeobox protein encoded by vnd during embryonic development. FBgn0265174 UniProtKB "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere. (UniProtKB:Q9V7W1)" FBgn0265177 Alliance Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in 2-oxoglutarate metabolic process. Is expressed in adult head. FBgn0265178 Alliance "Predicted to enable lipoyltransferase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic anal pad; embryonic/larval muscle cell; embryonic/larval muscle system; gut section; and posterior midgut primordium. Orthologous to human LIPT1 (lipoyltransferase 1)." FBgn0265180 Alliance Involved in mesoderm development. Is expressed in adult head; adult heart; and spermatozoon. FBgn0265182 Alliance "Predicted to be located in membrane. Is expressed in several structures, including CNS surface glial cell; antennal disc; embryonic/larval dorsal vessel; presumptive arista; and wing pouch. Orthologous to human NPDC1 (neural proliferation, differentiation and control 1)." FBgn0265184 Alliance "Predicted to enable U12 snRNA binding activity; mRNA binding activity; and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of U11/U12 snRNP and U12 snRNP. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human RNPC3 (RNA binding region (RNP1, RRM) containing 3)." FBgn0265185 Alliance Is expressed in adult head; embryonic proventriculus; embryonic/larval midgut; and gastric caecum. FBgn0265187 Alliance "Predicted to enable long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in several structures, including adult head; embryonic antennal sense organ; embryonic epipharynx; epithelium; and sensory cluster. Orthologous to human SLC27A1 (solute carrier family 27 member 1)." FBgn0265189 FlyBase Gene Snapshot "sudestada1 (sud1) encodes a prolyl hydroxylase that modifies a specific prolyl residue of the small ribosomal subunit protein encoded by RpS23. Lack of sud1 affects growth, triggers the unfolded protein response, as well as apoptosis and autophagy." FBgn0265190 FlyBase Gene Snapshot "Phosphatidylinositol glycan anchor biosynthesis class S (PIG-S) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane." FBgn0265191 FlyBase Gene Snapshot Glycogenin (Gyg) encodes a predicted glucosyltransferase that self-glucosylates to form an oligosaccharide primer that serves as substrate for glycogen synthase (Glys) and thus plays an essential role in glycogen biosynthesis. FBgn0265192 FlyBase Gene Snapshot Snipper (Snp) encodes a non-essential exonuclease in the DnaQ-H family. FBgn0265193 FlyBase Gene Snapshot Activating transcription factor-2 (Atf-2) encodes a trancription factor required for heterochromatin assembly. It is involved in stress response and fat metabolism regulation. FBgn0265194 UniProtKB Calcium channel mediating constitutive calcium ion entry. (UniProtKB:A8DYE2) FBgn0265257 Alliance Predicted to enable SUMO-ubiquitin ligase activity. FBgn0265262 UniProtKB "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). (UniProtKB:P48602)" FBgn0265264 Alliance Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). FBgn0265265 Alliance "Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of PAM complex, Tim23 associated import motor." FBgn0265267 Alliance "Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H)." FBgn0265268 Alliance Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. FBgn0265271 Alliance Predicted to enable carboxylesterase activity. Predicted to be involved in cellular lipid metabolic process. Predicted to be active in mitochondrion. Orthologous to human ABHD11 (abhydrolase domain containing 11). FBgn0265272 Alliance Orthologous to human PEBP4 (phosphatidylethanolamine binding protein 4). FBgn0265274 FlyBase Gene Snapshot "Innexin 3 (Inx3) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the product of Inx2. Loss of Inx3 leads to the destabilization of the products of ogre, Inx2 and shg at the plasma membrane, suggesting that these four proteins form a complex." FBgn0265276 FlyBase Gene Snapshot "lethal (3) neo38 (l(3)neo38) encodes an essential regulator of neuromuscular junction and brain development, required at post-embryonic stages." FBgn0265296 FlyBase Gene Snapshot "Down syndrome cell adhesion molecule 2 (Dscam2) encodes a transmembrane protein. Its alternative splicing produces two biochemically distinct homophilic binding proteins expressed in different cells. It can mediate both repulsion and adhesion between neurons and contributes to boundary formation, neurite targeting and synapse formation in the brain." FBgn0265297 UniProtKB "Binds the poly(A) tail of mRNA (PubMed:2125288). Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex (PubMed:28388438). Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively (PubMed:28388438). The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors, whereas the repressor complex (Atx2-Not1 repressor complex) promotes Not1-dependent post-transcriptional gene silencing and supports high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). In 0-1 hour embryos, forms a ribonucleoprotein complex (RNP) with me31B, eIF4E1, tral and cup which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934). (UniProtKB:P21187)" FBgn0265298 FlyBase Gene Snapshot "SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site." FBgn0265302 Alliance Located in cytosol. Is expressed in organism. FBgn0265342 Alliance "Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be part of mitochondrial respiratory chain complex IV. Orthologous to human COX7C (cytochrome c oxidase subunit 7C)." FBgn0265349 Alliance Involved in sexual reproduction. Located in extracellular space. FBgn0265351 FlyBase Gene Snapshot Golgi GDP-fucose transporter (Gfr) encodes a Golgi transmembrane transporter that specifically imports GDP-L-fucose from the cytosol into the Golgi lumen where it is used for the fucosylation of N- and O-glycans. FBgn0265356 FlyBase Gene Snapshot thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability. FBgn0265367 Alliance Is expressed in testis. FBgn0265376 Alliance Is expressed in organism. FBgn0265413 Alliance Predicted to be involved in septate junction assembly. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0265416 FlyBase Gene Snapshot "Neuropilin and tolloid-like (Neto) encodes a transmembrane protein with no catalytic activities. It associates with several inotropic glutamate receptors (iGluRs) and modulates their sub-cellular distribution and function. At the neuromuscular junction, it enables iGluR clustering at the onset of synaptogenesis, and triggers postsynaptic differentiation." FBgn0265444 Alliance Involved in spermatogenesis. FBgn0265464 FlyBase Gene Snapshot "TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr." FBgn0265487 FlyBase Gene Snapshot "muscleblind (mbl) encodes an RNA binding protein that regulates RNA metabolism at the levels of alternative splicing, transcript localization and miRNA and circRNA biogenesis. It contributes to terminal muscle, eye and neural differentiation." FBgn0265509 Alliance Involved in spermatogenesis. FBgn0265512 FlyBase Gene Snapshot mulet (mlt) encodes a tubulin-specific chaperone E-like protein involved in sperm individualization and regulation of microtubule depolymerization. FBgn0265523 Interactive Fly SMRT-related ecdysone receptor-interacting protein - a corepressor that mediates transcriptional silencing of the Ecdysone receptor:Ultraspiracle heterodimer FBgn0265574 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Part of Prp19 complex. Is expressed in adult head and organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like)." FBgn0265575 UniProtKB Important role in absorption of dietary peptides. High-affinity transporter of alanylalanine. Dipeptide transport activity is proton dependent. (UniProtKB:P91679) FBgn0265577 Alliance Involved in positive regulation of female receptivity and response to insect. Predicted to be active in extracellular space. Is expressed in adult midgut; embryonic/larval fat body; and embryonic/larval hemocyte. FBgn0265585 Alliance Involved in spermatogenesis. FBgn0265593 Alliance Involved in spermatogenesis. FBgn0265595 Alliance Predicted to enable calcium ion binding activity. Is expressed in adult head. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1) and KCNIP4 (potassium voltage-gated channel interacting protein 4). FBgn0265597 FlyBase Gene Snapshot radish (rsh) encodes a protein involved in anesthesia-resistant memory and heart contraction regulation. FBgn0265598 FlyBase Gene Snapshot "Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues." FBgn0265605 FlyBase Gene Snapshot Ras-related protein interacting with calmodulin (Ric) encodes a Ras-like GTPase that influences p38 signaling. It functions to promote tolerance to a variety of stresses. FBgn0265606 UniProtKB "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (UniProtKB:Q24178)" FBgn0265607 Alliance Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and motor neuron axon guidance. FBgn0265623 FlyBase Gene Snapshot Suppressor of zeste 2 (Su(z)2) encodes a protein that regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z. FBgn0265630 FlyBase Gene Snapshot "strawberry notch (sno) encodes a nuclear protein that functions in Notch signaling pathway during imaginal disc development. In the developing eye imaginal disc, the product of sno functions downstream of RTK signaling to regulate the expression of the products of N and Delta in the specification of cone and pigment cells." FBgn0265642 Alliance Involved in spermatogenesis. FBgn0265697 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0265726 FlyBase Gene Snapshot "Nna1 carboxypeptidase (Nna1) encodes a highly conserved cytoplasmic carboxypeptidase. Nna1 loss leads to neurodegeneration by causing mitochondrial dysfunction. It has been proposed to function as protein-deglutamylases, possibly interacting with and modifying tubulin." FBgn0265767 FlyBase Gene Snapshot zydeco (zyd) encodes a potassium-dependent sodium/calcium exchanger found in cortex glia. It is thought to serve as a key calcium export pathway to control calcium oscillations that occur in membrane microdomains of the glial cell. FBgn0265778 FlyBase Gene Snapshot "PDZ domain-containing guanine nucleotide exchange factor (PDZ-GEF) encodes a guanine nucleotide exchange factor for the product of Rap1. The product of PDZ-GEF contributes to ventral furrow formation, border cell migration, macrophage migration, epithelial migration and morphogenesis, eye development, ovary development, spermathecae formation, germline stem cell maintenance in the testis, adherens junction formation, and anchorage of stem cells to niche." FBgn0265784 FlyBase Gene Snapshot Cyclic-AMP response element binding protein B (CrebB) encodes a transcription factor that acts downstream of PKA signalling. It is involved in long-term memory formation and plays an important role in regulating genes required for memory. FBgn0265796 Alliance Involved in spermatogenesis. FBgn0265935 Alliance "Predicted to enable actin filament binding activity. Involved in adult somatic muscle development and defense response to fungus. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; dorsal pharyngeal muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to several human genes including CORO1A (coronin 1A); CORO1B (coronin 1B); and CORO1C (coronin 1C)." FBgn0265959 FlyBase Gene Snapshot "retinal degeneration C (rdgC) encodes a serine/threonine phosphatase that binds Ca2+/calmodulin and contains 2 Ca2+-binding EF-hand motifs. It promotes the dephosphorylation of the product of ninaE, which prevents its internalization. It also promotes the dephosphorylation of the product of trp at specific site affecting the frequency response to modulated light." FBgn0265968 FlyBase Gene Snapshot "Transcription factor B5 (Tfb5) encodes a subunit of the basal transcription and DNA repair factor TFIIH, which operates in transcription and DNA repair." FBgn0265974 UniProtKB "Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Botv is the trigger of heparan sulfate chain initiation and polymerization takes place by a complex of ttv and sotv. Plays a central role in the diffusion of morphogens hedgehog (hh), wingless (wg) and decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis which are required for movement of hh, dpp and wg morphogens. (UniProtKB:Q9V730)" FBgn0265991 FlyBase Gene Snapshot "Z band alternatively spliced PDZ-motif protein 52 (Zasp52) encodes a member of the Zasp protein family. It is a scaffold protein that binds the product of Actn and localizes to muscle attachment sites and Z-discs in muscle cells, as well as localizing cortically in non-muscle cells. It plays a role in muscle development, especially in myofibril assembly." FBgn0265998 FlyBase Gene Snapshot "Darkener of apricot (Doa) encodes an essential Ser/Thr protein kinase with SR proteins (RNA maturation) and the product of eEF1gamma (microtubule-based organelle transport) as substrates. It contributes to somatic sex determination (splicing of dsx transcript) and development of eye, wing, leg, oocyte and bristles." FBgn0266000 Alliance "Predicted to be involved in negative regulation of cell migration. Predicted to be part of Sin3-type complex. Is expressed in several structures, including auditory system neurons; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Orthologous to human SINHCAF (SIN3-HDAC complex associated factor)." FBgn0266019 FlyBase Gene Snapshot rudhira (rudhira) is expressed in nephrocytes and encodes a protein that regulates macromolecular uptake and clearance by nephrocytes to maintain tissue homeostasis. FBgn0266027 Alliance Involved in spermatogenesis. FBgn0266029 Alliance Predicted to enable U6 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4 snRNP and U4/U6 x U5 tri-snRNP complex. FBgn0266046 Alliance Involved in negative regulation of imaginal disc-derived wing vein specification. FBgn0266053 FlyBase Gene Snapshot Protein associated with topo II related - 1 (Patr-1) encodes a P body component involved in mRNA decapping and regulation of synaptic growth at neuromuscular junctions. FBgn0266064 FlyBase Gene Snapshot Glycogen synthase (Glys) encodes a glycosyltransferase that catalyzes linkage of glucose monomers into glycogen. Regulation of the product of Glys activity by glucose 6-phosphate and phosphorylation helps control cellular glycogen levels. FBgn0266076 Alliance "Involved in learning or memory; negative regulation of insulin receptor signaling pathway; and regulation of circadian sleep/wake cycle, sleep. Predicted to be part of RISC complex." FBgn0266083 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in larval lymph gland hemopoiesis and sex-chromosome dosage compensation. Located in nucleus." FBgn0266084 FlyBase Gene Snapshot "Formin homology 2 domain containing (Fhos) encodes a protein that regulates actin-dependent remodeling of muscle cytoskeleton via induction of actin stress fibers, directs macrophage migration during cellular immune response, and is involved in autophagic programmed cell death." FBgn0266098 FlyBase Gene Snapshot "rugose (rg) encodes a protein involved in synaptic architecture, brain morphology and associative learning." FBgn0266099 Alliance Orthologous to human NSUN7 (NOP2/Sun RNA methyltransferase family member 7). FBgn0266100 Alliance Predicted to enable metallodipeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. Orthologous to human DPEP2 (dipeptidase 2). FBgn0266101 Alliance "Predicted to be involved in signal transduction. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval muscle system; embryonic/larval nervous system; ganglia; and mesoderm." FBgn0266106 Alliance Involved in female meiotic nuclear division. FBgn0266107 Alliance Involved in female meiotic nuclear division. FBgn0266108 Alliance Involved in female meiotic nuclear division. FBgn0266109 Alliance Involved in female meiotic nuclear division. FBgn0266110 Alliance Involved in female meiotic nuclear division. FBgn0266111 FlyBase Gene Snapshot anastral spindle 3 (ana3) encodes a centriole and basal body localized protein that is required for the proper function of these organelles. FBgn0266124 FlyBase Gene Snapshot ghiberti (ghi) encodes a protein homologous to the mammalian small regulatory subunit of serine palmitoyltransferase. Mutations in ghi affect the first steps of sphingolipids biosynthesis and disrupt meiotic cytokinesis of males. FBgn0266128 Alliance Involved in gravitaxis. FBgn0266129 UniProtKB Has a regulatory role during midline cell development. (UniProtKB:P14083) FBgn0266130 Alliance Involved in gravitaxis. FBgn0266131 Alliance Involved in gravitaxis. FBgn0266132 Alliance Involved in gravitaxis. FBgn0266133 Alliance Involved in gravitaxis. FBgn0266134 Alliance Involved in gravitaxis. FBgn0266135 Alliance Involved in gravitaxis. FBgn0266136 FlyBase Gene Snapshot "Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance." FBgn0266137 UniProtKB "Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (UniProtKB:Q24563)" FBgn0266170 Alliance Predicted to enable DNA binding activity. FBgn0266181 Alliance "Involved in positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; and embryonic/larval central nervous system." FBgn0266186 FlyBase Gene Snapshot Vesicle-associated membrane protein 7 (Vamp7) encodes an R type SNARE protein. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Syx17 and Snap29. It localizes to endosomes in a Rab21 and Sbf dependent manner. FBgn0266195 FlyBase Gene Snapshot "Trimethylguanosine synthase 1 (Tgs1) encodes an essential cytoplasmic enzyme that hypermethylates the 7-methylguanosine cap of snRNPs to a 2,2,7-trimethylguanosine cap. It is required in the motor system for viability and motor behaviour." FBgn0266236 Alliance Is expressed in cephalic furrow. FBgn0266261 Alliance Enables hormone activity. Involved in positive regulation of growth. Is active in extracellular space. FBgn0266268 UniProtKB Catalyzes the ferrous insertion into protoporphyrin IX (PubMed:9712849). Terminal enzyme in heme biosynthesis (PubMed:9712849). Contains four conserved cysteines that function as cluster ligands and play a crucial role in maintaining protein structure (PubMed:9712849). (UniProtKB:Q9V9S8) FBgn0266282 FlyBase Gene Snapshot Structural maintenance of chromosomes 6 (SMC6) encodes a subunit of the SMC5/6 protein complex. It is involved genotoxic stress and response to caffeine. FBgn0266284 UniProtKB GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control. (UniProtKB:Q9W590) FBgn0266346 Alliance Contributes to intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Involved in monoatomic cation transmembrane transport. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in achromatopsia 3; color blindness; retinitis pigmentosa; and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1) and CNGB3 (cyclic nucleotide gated channel subunit beta 3). FBgn0266347 FlyBase Gene Snapshot nicotinic Acetylcholine Receptor alpha4 (nAChRalpha4) encodes a four-pass transmembrane channel that is part of a nicotinic acetycholine receptor complex. It promotes sleep and its expression level peaks when sleep need is high. Its activity is inhibited by the product of qvr. FBgn0266354 Alliance Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). FBgn0266363 Alliance Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). FBgn0266369 FlyBase Gene Snapshot "Microsomal triacylglycerol transfer protein (Mtp) encodes a phosphatidylcholine transporter involved in lipoprotein metabolism, tracheal system lumen formation and neuron development." FBgn0266377 UniProtKB "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death (PubMed:23509299). (UniProtKB:Q6NNF2)" FBgn0266409 Alliance Predicted to be involved in cell-cell adhesion. Predicted to be located in septate junction. Predicted to be active in cell-cell junction. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to several human genes including TMEM47 (transmembrane protein 47). FBgn0266410 Alliance Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in determination of digestive tract left/right asymmetry and positive regulation of receptor signaling pathway via JAK-STAT. Is active in cytoplasm. Is expressed in organism; spermatozoon; and wing disc. Orthologous to human ZFAND5 (zinc finger AN1-type containing 5) and ZFAND6 (zinc finger AN1-type containing 6). FBgn0266411 UniProtKB Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. (UniProtKB:Q24167) FBgn0266417 FlyBase Gene Snapshot ringmaker (ringer) encodes a protein involved in microtubule bundle formation and polymerization. FBgn0266418 FlyBase Gene Snapshot "wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time." FBgn0266420 FlyBase Gene Snapshot Otefin (Ote) encodes a nuclear membrane-associated protein that acts in concert with BMP/Dpp signaling to mediate bam transcriptional silencing. Its roles include oogenesis and germline stem cell self-renewal and differentiation. FBgn0266429 FlyBase Gene Snapshot Allatostatin A receptor 1 (AstA-R1) encodes a G-protein coupled receptor for the neuropeptide encoded by AstA. FBgn0266432 Alliance Predicted to enable nucleotide binding activity. FBgn0266434 Alliance "Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; and gut section." FBgn0266435 Alliance "Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section. Orthologous to human CHDH (choline dehydrogenase)." FBgn0266437 Alliance Predicted to be located in membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). FBgn0266438 UniProtKB Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly (By similarity). (UniProtKB:Q8MT80) FBgn0266441 Alliance "Predicted to enable DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including dorsal ectoderm anlage; embryonic/larval nervous system; ganglia; and ventral nerve cord primordium." FBgn0266445 Alliance "Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic/larval midgut primordium; ganglia; and sensory nervous system primordium." FBgn0266446 Alliance Is expressed in adult head and adult heart. FBgn0266448 Alliance Is expressed in adult head and adult heart. FBgn0266449 UniProtKB Member of the dosage-dependent hierarchy effective upon white gene expression. (UniProtKB:Q9V447) FBgn0266450 FlyBase Gene Snapshot "Kruppel homolog 1 (Kr-h1) encodes a transcriptional regulator involved in axon pathfinding, neurite and axon remodeling as well as pupal photoreceptor maturation. In all cases, the function of the product of Kr-h1 is linked to that of the 20-hydroxyecdysone hormone." FBgn0266451 UniProtKB Plays an important role in the regulation of tissue responsiveness to oxygen deprivation. (UniProtKB:C0HK95) FBgn0266452 FlyBase Gene Snapshot CTP synthase (Ctps) encodes the rate limiting enzyme for the de novo synthesis of the nucleotide CTP. It forms an evolutionarily conserved filamentous structure termed the cytoophidium. It acts downstream of the product of Myc and is required for Myc-mediated cell size control. FBgn0266464 FlyBase Gene Snapshot "N-ethylmaleimide-sensitive factor 2 (Nsf2) encodes a homohexameric AAA ATPase that functions to recycle SNARE complex components subsequent to membrane fusion. In the tracheal system, it is required for tube growth and connectivity within the terminal cell." FBgn0266465 FlyBase Gene Snapshot Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system. FBgn0266490 Alliance Is expressed in adult head. FBgn0266491 UniProtKB "Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction. (UniProtKB:C0HJH4)" FBgn0266492 UniProtKB "Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction. (UniProtKB:C0HJH3)" FBgn0266518 FlyBase Gene Snapshot DNA polymerase interacting tpr containing protein of 47kD (Dpit47) encodes a TPR motif containing protein that appears to act as a co-chaperone protein in the Hsp90 pathway. FBgn0266521 FlyBase Gene Snapshot "stathmin (stai) encodes a tubulin binding protein involved in axo-dendritic transport, gamete generation and synaptic growth at neuromuscular junction." FBgn0266557 FlyBase Gene Snapshot "kismet (kis) encodes a chromodomain containing ATP-dependent transcription factor that controls gene expression through epigenetic mechanisms. The roles of the product of kis include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory." FBgn0266566 Alliance "Predicted to be involved in several processes, including microtubule organizing center organization; neuron migration; and tube formation. Predicted to be active in centriole and centrosome. Is expressed in several structures, including antennal primordium; dorsal sensory complex primordium; embryonic head sensory system; sensory nervous system primordium; and ventral sensory complex anlage. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 16 and Senior-Loken syndrome. Orthologous to human SDCCAG8 (SHH signaling and ciliogenesis regulator SDCCAG8)." FBgn0266568 Alliance "Involved in regulation of circadian sleep/wake cycle, sleep. Located in cytoplasm. Is expressed in organism." FBgn0266569 Alliance Predicted to enable protein homodimerization activity. Involved in response to wounding. Predicted to be located in extracellular region. FBgn0266570 UniProtKB "Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). (UniProtKB:Q7K4H4)" FBgn0266572 FlyBase Gene Snapshot "ellipsoid body open (ebo) encodes a protein that complexes with actin, the product of chic, and Ran-GTPase to mediate actin nuclear export. Loss of ebo during development results in defects in the ellipsoid body of the central complex. In the adult brain, accumulation of nuclear actin results in the inhibition of the product of bs and subsequent loss of visual orientation memory." FBgn0266573 Alliance Predicted to enable ACA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0266574 Alliance Predicted to enable ACA codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0266579 FlyBase Gene Snapshot "tau (tau) encodes a microtubule associated protein, which is a specific marker for posterior signalling center cells, a subtype of immune cells. Its human ortholog is well known for its role in the stabilisation of the neuronal cytoskeleton and implication in diverse neuronal diseases, including Alzheimer's disease, where the accumulation of tau protein causes neuronal decay." FBgn0266580 FlyBase Gene Snapshot Glycoprotein 210 kDa (Gp210) encodes a glycoprotein of the nuclear pore complex. FBgn0266581 UniProtKB "Probable RNA-dependent helicase. Functions in cell growth and proliferation. May have a role in ribosome biogenesis and, consequently, in protein biosynthesis. (UniProtKB:Q9VD51)" FBgn0266582 UniProtKB Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (UniProtKB:Q9VZU4) FBgn0266585 Alliance Predicted to enable CUG codon-amino acid adaptor activity. Predicted to be involved in translation. Predicted to be located in cytosol. FBgn0266598 FlyBase Gene Snapshot "kinetochore Mis12-Ndc80 network component 2 (Kmn2) encodes a component of the Ndc80 complex, an essential kinetochore constituent." FBgn0266599 FlyBase Gene Snapshot "Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response." FBgn0266615 Alliance Orthologous to human SMKR1 (small lysine rich protein 1). FBgn0266631 Alliance Is expressed in mesoderm. FBgn0266666 UniProtKB Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. (UniProtKB:Q9VM46) FBgn0266667 UniProtKB Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation. (UniProtKB:Q9VSJ8) FBgn0266668 FlyBase Gene Snapshot Exocyst 84 (Exo84) encodes an exocyst component involved in epithelial polarity. It mediates the apical localization of the transmembrane protein encoded by crb. FBgn0266669 UniProtKB Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProtKB:Q9VVG4) FBgn0266670 UniProtKB Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProtKB:Q9VQQ9) FBgn0266671 UniProtKB Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProtKB:Q9V8K2) FBgn0266672 FlyBase Gene Snapshot Secretory 8 (Sec8) encodes a component of the exocyst complex involved in tethering secretory vesicles to the plasma membrane and microtubule assembly suppression. Sec8 mutants show increased microtubules and alterations in microtubule-dependent processes. FBgn0266673 UniProtKB Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProtKB:Q9XTM1) FBgn0266674 UniProtKB Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProtKB:Q9VDE6) FBgn0266696 Alliance "Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage in statu nascendi; dorsal ectoderm; and dorsal ectoderm anlage. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin)." FBgn0266708 UniProtKB Required for mitochondrial complex IV activity. May be involved in non-associative learning. (UniProtKB:Q7JVA5) FBgn0266709 UniProtKB "Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. (UniProtKB:Q9VU41)" FBgn0266710 FlyBase Gene Snapshot hog (hog) encodes a short protein required for centripetal follicle cell migration and eggshell formation. It may play a role in modulating transcriptional fidelity in the early embryo. FBgn0266711 FlyBase Gene Snapshot "Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto." FBgn0266717 FlyBase Gene Snapshot "BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation." FBgn0266719 UniProtKB "Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells. May also function in the maturation and exocytosis of the SLs. (UniProtKB:Q9VBY8)" FBgn0266720 Alliance Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in Golgi to plasma membrane transport; synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in secretory granule membrane. Colocalizes with secretory granule. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to several human genes including SNAP25 (synaptosome associated protein 25). FBgn0266721 Alliance Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Predicted to be involved in intracellular protein transport. Predicted to be part of SNARE complex. Is expressed in adult head. Orthologous to human NAPG (NSF attachment protein gamma). FBgn0266722 Alliance "Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Used to study autosomal recessive intellectual developmental disorder. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy. Orthologous to several human genes including TRAPPC6B (trafficking protein particle complex subunit 6B)." FBgn0266723 Alliance Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Is expressed in adult head and organism. Orthologous to human TRAPPC5 (trafficking protein particle complex subunit 5). FBgn0266724 UniProtKB May play a role in vesicular transport from endoplasmic reticulum to Golgi. Involved in dsRNA uptake. (UniProtKB:Q9VUZ1) FBgn0266756 FlyBase Gene Snapshot "bitesize (btsz) encodes a membrane-trafficking protein that contributes to actin cytoskeleton organization. It is involved in the establishment of planar cell polarity, apical junction assembly and the morphogenesis of salivary glands and the tracheal system." FBgn0266757 FlyBase Gene Snapshot misfire (mfr) is a ferlin gene that encodes a protein involved in gamete generation. FBgn0266758 FlyBase Gene Snapshot "Extended synaptotagmin-like protein 2 (Esyt2) encodes a member of the Synaptotagmin family that localizes to the endoplasmic reticculum (ER). In axonal ER of motorneurons, it may be involved in coordinating intracellular calcium dynamics and constitutive membrane trafficking." FBgn0266801 Alliance "Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; dorsal ectoderm; epithelium; and sensory nervous system primordium." FBgn0266848 FlyBase Gene Snapshot "wings apart (wap) encodes a protein required for growth, viability, muscle development, and proper wing venation. It physically interacts with the product of ds, and functions in the Hippo pathway to regulate growth." FBgn0266869 Alliance Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA branch site recognition. Predicted to be part of U2 snRNP. FBgn0266901 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0266902 Alliance Is expressed in terminal epithelium of testis. FBgn0266916 FlyBase Gene Snapshot "Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle." FBgn0266917 Alliance Predicted to enable RNA binding activity. Involved in spermatogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human SF3A1 (splicing factor 3a subunit 1). FBgn0266918 Alliance "Predicted to enable zinc ion binding activity. Predicted to be active in nucleus. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; ganglia; and mesoderm. Orthologous to human ZFTRAF1 (zinc finger TRAF-type containing 1)." FBgn0266937 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. FBgn0266982 Alliance Is expressed in embryonic/larval central nervous system and larval ventral nerve cord. FBgn0267001 FlyBase Gene Snapshot "Tenascin accessory (Ten-a) encodes a type II dimeric transmembrane protein with a extracellular domain that mediates homophilic interactions with itself and with the product of Ten-m. It also interacts intracellularly with cytoskeleton regulatory proteins. It regulates axon guidance in embryonic nervous system, synaptic partner matching as well as synaptic organization in olfactory and neuromuscular systems." FBgn0267002 UniProtKB "Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons. (UniProtKB:A1ZAJ2)" FBgn0267033 FlyBase Gene Snapshot maternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production. FBgn0267102 Alliance Involved in spermatogenesis. FBgn0267182 Alliance Is expressed in testis. FBgn0267230 Alliance Involved in spermatogenesis. FBgn0267252 FlyBase Gene Snapshot G protein subunit gamma at 30A (Ggamma30A) encodes the gamma subunit of a heterotrimeric G protein complex. It functions in rhodopsin-mediated signaling in photoreceptor cells. Post-translational farnesylation of the product of Ggamma30A facilitates membrane attachment of the visual Gbeta/gamma complex. FBgn0267291 Alliance Involved in spermatogenesis. FBgn0267326 FlyBase Gene Snapshot "Neurotransmitter transporter-like (Ntl) encodes a glycine transporter of the SLC6 class, closely related to neurotransmitter transporters and other amino acid transporters. Ntl expression is testes-specific and its mutants are male-sterile, producing sperm with a significant reduction in glycylated tubulin." FBgn0267327 FlyBase Gene Snapshot Accessory gland-specific peptide 33A (Acp33A) encodes a peptide produced by the male accessory glands and transferred to females during mating. FBgn0267330 FlyBase Gene Snapshot KDEL receptor (KdelR) encodes a protein required for retrieval of ER proteins from the Golgi. Loss of function is lethal and results in larval cuticle defects. It is essential for the ER retention of some but not all KDEL-containing proteins in the salivary gland ER. FBgn0267336 FlyBase Gene Snapshot Glucose transporter 4 enhancer factor (Glut4EF) encodes a transcription factor important for developmental patterning and morphogenesis events. FBgn0267337 FlyBase Gene Snapshot "rotund (rn) encodes a member of the Kruppel zinc-finger transcription factor family. It functions as an olfactory neuron specification factor required for diversification of multiple developmental lineages. rn mutants are defective for multiple distal structures in the adult, including smaller legs, wings and eyes." FBgn0267339 FlyBase Gene Snapshot "p38c MAP kinase (p38c) encodes a protein involved in the stress and wound responses, regulating the expression of Duox and Ddc." FBgn0267347 FlyBase Gene Snapshot squash (squ) encodes a protein acting in the piRNA pathway that responds to transposase activity in the germline. FBgn0267348 FlyBase Gene Snapshot "Laminin B2 (LanB2) encodes a subunit of laminin, a heterotrimeric protein found in the extracellular matrix (ECM) and a major component of the basal lamina. Laminins interact with a variety of cell surface molecules such as integrin receptors and other secreted ECM components. It contributes to ECM organization, tissue adhesion, cell motility and developmental patterning." FBgn0267350 FlyBase Gene Snapshot "Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes." FBgn0267351 FlyBase Gene Snapshot Topoisomerase I-interacting protein (Topors) encodes a RING-finger containing putative dual Ubiquitin/SUMO ligase. It is required in the male germline for maintenance of nuclear shape and meiosis I chromosome segregation. It also targets ubiquitination of the developmental transcription factor encoded by hry. FBgn0267363 FlyBase Gene Snapshot JYalpha (JYalpha) is a gene essential for male fertility as mutants produce immotile sperm. FBgn0267365 Alliance "Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm." FBgn0267366 FlyBase Gene Snapshot "milkah (mil) encodes a nucleosome assembly factor of the Nap family. It is involved in spermatogenesis, long-term memory formation and male courtship." FBgn0267376 FlyBase Gene Snapshot "Selenoprotein R (SelR) encodes a methionine sulfoxide reductase, which specifically converts the R isomer of methionine sulfoxide back to methionine. It reverses the modification of actin performed by the product of Mical, thus restoring actin to normal function. It contributes to actin organization in neuronal and muscle tissue." FBgn0267378 UniProtKB "Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi (PubMed:19837035, PubMed:24786584). Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking (PubMed:23720043, PubMed:24786584). May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part (By similarity). Functions in cytokinesis by regulating contractile ring formation and vesicle trafficking during cleavage furrow ingression (PubMed:24786584). May also have a role in the intital steps of central spindle formation (PubMed:24786584). Can also bind phosphatidylinositol-3-phosphate and phosphatidylinositol-5-phosphate in vitro (PubMed:24786584). (UniProtKB:Q9VQ93)" FBgn0267383 Alliance Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). FBgn0267384 Alliance "Predicted to enable ubiquitin conjugating enzyme activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including adult head; cephalic furrow; embryonic/larval midgut; germ layer; and presumptive embryonic/larval central nervous system. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2)." FBgn0267385 FlyBase Gene Snapshot "Pyruvate kinase (Pyk) encodes an enzyme that catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP." FBgn0267390 FlyBase Gene Snapshot drop out (dop) encodes a microtubule-associated Ser/Thr (MAST) protein kinase. Among its potential substrates is the microtubule motor Dynein. The product of dop is required for membrane growth and polarity during cell formation in the early cleavage stage embryo. FBgn0267398 FlyBase Gene Snapshot Yeti (Yeti) encodes an essential chromatin protein that interacts with subunits of the Tip60 chromatin remodeling complex. Yeti loss results in lethality at the larval stage and in chromosome organization defects. FBgn0267407 Interactive Fly ubiquitin conjugation enzyme - plays a role in protein degradation - mutation disrupts early steps of courtship behavior in Drosophila males and the development of their sperm FBgn0267408 FlyBase Gene Snapshot Aldehyde oxidase 1 (AOX1) encodes a pyridoxal oxidase involved in pyridoxal metabolism. FBgn0267428 Alliance Predicted to be involved in establishment of synaptic specificity at neuromuscular junction. Predicted to be located in neuron projection membrane. Predicted to be active in neuron projection. Is expressed in wing disc. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). FBgn0267429 Alliance Predicted to enable sucrose:proton symporter activity. Involved in visual perception. Located in synaptic vesicle. Is expressed in adult head and photoreceptor neurons. Orthologous to several human genes including SLC45A1 (solute carrier family 45 member 1). FBgn0267430 Interactive Fly mechanically activated cation channel - stretch-activated mechanotransduction - mechanical nociceptor FBgn0267431 Alliance Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be located in cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. FBgn0267432 FlyBase Gene Snapshot male fertility factor kl3 (kl-3) encodes a dynein heavy chain that is a component of a microtubule motor complex. This motor activity is essential only for spermatogenesis. Lack of kl-3 results in loss of the axonemal out dynein arms in the spermatid tail. FBgn0267433 Alliance "Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Involved in flagellated sperm motility. Part of axonemal dynein complex. Is active in sperm flagellum. Is expressed in adult head; organism; spermatogonium; spermatozoon; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9)." FBgn0267435 UniProtKB Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion. (UniProtKB:P12024) FBgn0267449 Alliance Is expressed in testis. Orthologous to human WDR49 (WD repeat domain 49). FBgn0267486 FlyBase Gene Snapshot "Protein tyrosine phosphatase 36E (Ptp36E) encodes a tyrosine-specific protein phosphatase. It is probably a cytoplasmic protein, as it lacks a predicted transmembrane domain, but little is known about its function." FBgn0267487 FlyBase Gene Snapshot "Protein tyrosine phosphatase 61F (Ptp61F) encodes a non-receptor protein tyrosine phosphatase. It is known to act as a negative regulator of various kinase-dependent signalling pathways, including the JAK-STAT, Insulin-like Receptor, EGFR, and Pvr pathways in a wide variety of contexts." FBgn0267488 FlyBase Gene Snapshot "Macroglobulin complement-related (Mcr) encodes a transmembrane protein of the conserved thioester-containing protein (TEP) superfamily including macroglobulins and complement proteins. It is a core component of septate junctions, which provide an essential paracellular barrier to epithelia." FBgn0267490 Alliance Predicted to be involved in sperm DNA condensation. Predicted to be part of chromatin. FBgn0267491 Alliance Predicted to be involved in sperm DNA condensation. Predicted to be part of chromatin. FBgn0267492 Alliance Predicted to be involved in sperm DNA condensation. Predicted to be part of chromatin. FBgn0267493 Alliance Predicted to be involved in sperm DNA condensation. Predicted to be part of chromatin. FBgn0267497 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267498 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267499 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267501 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267502 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267504 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267505 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267506 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267507 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267512 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267516 Alliance Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. FBgn0267571 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267572 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. FBgn0267576 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267578 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267579 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267580 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267611 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. FBgn0267665 Alliance Is expressed in brain; larval ventral nerve cord; ventral midline of embryo; and ventral neurectoderm. FBgn0267666 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267668 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267675 Alliance Is expressed in testis. FBgn0267682 Alliance Involved in positive regulation of Toll signaling pathway and response to Gram-positive bacterium. Is active in nucleus. FBgn0267689 Alliance Is expressed in organism and spermatozoon. FBgn0267698 FlyBase Gene Snapshot "p21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo." FBgn0267704 Alliance Involved in follicle cell of egg chamber development; male courtship behavior; and piRNA-mediated retrotransposon silencing by heterochromatin formation. Located in Yb body. FBgn0267707 Alliance "Is expressed in several structures, including adult epithelial cell; brain; gonad; imaginal disc; and somatic precursor cell." FBgn0267728 FlyBase Gene Snapshot off-track2 (otk2) encodes a single-pass transmembrane protein with extracellular Ig-like repeats that functions as a coreceptor for the product of Wnt2. FBgn0267790 FlyBase Gene Snapshot "rumpelstiltskin (rump) encodes the Drosophila hnRNP M homolog. It binds to nanos and osk mRNAs and plays a role in mRNA localization to the germ plasm by diffusion/entrapment during late stages of oogenesis. It also binds to exonic splicing enhancers on pre-mRNA targets, implicating it as a splicing factor." FBgn0267791 FlyBase Gene Snapshot "Heterogeneous nuclear ribonucleoprotein K (HnRNP-K) encodes a member of the hnRNP family of DNA/RNA binding proteins. It localizes, along with other hnRNPs, in nucleoplasmic omega speckles. It is involved in gene regulation, post-transcriptional RNA processing and RNA transport." FBgn0267792 Alliance Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval posterior spiracle; mesoderm; and pole plasm. FBgn0267794 Alliance Is expressed in antennal disc; eye disc; leg disc; and wing disc. FBgn0267795 UniProtKB "Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies. (UniProtKB:Q9VUC6)" FBgn0267796 FlyBase Gene Snapshot Transmembrane channel-like (Tmc) encodes a protein involved in proprioception and locomotory behavior in larvae. FBgn0267821 FlyBase Gene Snapshot "daughterless (da) encodes a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation." FBgn0267823 FlyBase Gene Snapshot "GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductaseGDP-L-fucose synthase (Gmer) encodes an enzyme that catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-L-fucose, involving an epimerase and a reductase reaction. It is involved in the last step of the 'de novo' synthesis of GDP-L-fucose from GDP-mannose." FBgn0267824 FlyBase Gene Snapshot "Proline-rich Akt substrate 40 kDa (PRAS40) encodes a protein that functions to link Insulin/IGF signaling and the activation of the product of mTor in a tissue-specific manner, affecting the activity of the product of mTor in the ovary but not in other fly tissues." FBgn0267828 FlyBase Gene Snapshot Fatty acid transport protein 1 (Fatp1) encodes a transmembrane protein with acyl-CoA synthetase activity required for photoreceptor survival. It is involved in the cellular uptake of long-chain fatty acids with a role in the catabolism of fatty acids as well as synthesis of triglycerides. FBgn0267849 FlyBase Gene Snapshot "Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome." FBgn0267861 Alliance "Predicted to enable RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Predicted to be active in nucleus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)." FBgn0267903 Alliance Predicted to be involved in sperm DNA condensation. FBgn0267904 Alliance Predicted to be involved in sperm DNA condensation. FBgn0267905 Alliance Predicted to be involved in sperm DNA condensation. FBgn0267912 UniProtKB "Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. (UniProtKB:Q9VXF1)" FBgn0267913 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. FBgn0267967 FlyBase Gene Snapshot corolla (corolla) encodes a protein phosphatase 1 binding protein involved in centromere clustering and meiotic nuclear division. FBgn0267971 Alliance Is expressed in prothoracic leg. FBgn0267972 FlyBase Gene Snapshot "Derlin-1 (Der-1) encodes a transmembrane protein in the endoplasmic reticulum (ER) that is required for the retro-translocation of misfolded ER proteins to the cytoplasm for ubiquitin-mediated protein degradation. This process is referred to as ""ER-Associated Degradation""." FBgn0267975 FlyBase Gene Snapshot vibrator (vib) is an essential gene that encodes a conserved phosphatidylinositol transfer protein. The vib protein is enriched at the cleavage furrow and it is required for cytokinesis. FBgn0267976 Alliance Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in adult head; adult heart; and organism. Orthologous to human TIMM23 (translocase of inner mitochondrial membrane 23) and TIMM23B (translocase of inner mitochondrial membrane 23 homolog B). FBgn0267977 FlyBase Gene Snapshot maternal haploid (mh) encodes a conserved protease that is essential for the integrity of paternal chromosomes during the first zygotic mitosis. FBgn0267978 FlyBase Gene Snapshot "apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding." FBgn0268063 FlyBase Gene Snapshot larval translucida (ltl) encodes a leucine-rich repeat protein involved in wing vein specification. FBgn0270924 Alliance "Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including antennal primordium; cuboidal/columnar epithelium; ganglia; head epidermis primordium; and mesoderm." FBgn0270925 Alliance Predicted to enable L-iditol 2-dehydrogenase (NAD+) activity. Predicted to be involved in sorbitol catabolic process. Is expressed in adult head and spermatozoon. FBgn0270926 Alliance Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). FBgn0270927 Alliance Enables beta-glucuronidase activity. Predicted to be involved in glucuronoside catabolic process. Located in membrane. Is expressed in adult head. Used to study Sly syndrome. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). FBgn0270928 FlyBase Gene Snapshot Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles. FBgn0275436 UniProtKB Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. (UniProtKB:O16129) FBgn0278604 FlyBase Gene Snapshot "dalmatian (dmt) encodes a nuclear protein that localizes to centromeric heterochromatin and other polytene chromosome bands. It is required to block expression of rpr and hid during the radiation resistant stage of embryonic development, when cells become irreversibly committed to cell fate." FBgn0278608 UniProtKB Binds preferentially single-stranded DNA and unwinds double-stranded DNA. (UniProtKB:Q24537) FBgn0283426 Alliance Involved in dorsal closure and negative regulation of JNK cascade. Is expressed in embryonic/larval central nervous system and embryonic/larval epidermis. FBgn0283427 FlyBase Gene Snapshot Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. FBgn0283432 Alliance Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0283433 Alliance Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0283434 Alliance Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in transport along microtubule. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). FBgn0283437 FlyBase Gene Snapshot "Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan." FBgn0283438 Alliance "Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human TRABD (TraB domain containing)." FBgn0283440 FlyBase Gene Snapshot sisters on the loose (solo) encodes a chromosome protein involved in the meiotic sister chromatid cohesion pathway. It is required for sister centromere cohesion in both male and female meiosis and for maintenance of synaptonemal complexes and normal levels of homolog crossing-over in female meiosis. FBgn0283442 FlyBase Gene Snapshot "vasa (vas) encodes Vasa (Vas) is a DEAD-box RNA helicase protein. It interacts with eIF5B and promotes translation of grk and mei-P26 mRNAs. Vas also functions in piRNA biogenesis as a component of an Amplifier complex. Maternally-expressed vas is required for oogenesis, transposon silencing in the female germ line, anterior-posterior embryonic patterning, and germ cell specification." FBgn0283450 Alliance Enables lactoylglutathione lyase activity. Involved in regulation of insulin receptor signaling pathway. Is expressed in adult head and organism. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). FBgn0283451 UniProtKB Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis. (UniProtKB:Q24206) FBgn0283461 FlyBase Gene Snapshot "Drosomycin (Drs) encodes an antifungal peptide that is expressed in the fat body during the systemic immune response, under the control of the Toll and (to a lesser extent) the immune deficiency (Imd) pathways. Drs is also constitutively expressed in certain tissue such as the spermatheca of females and in various epithelia, notably the trachea, where its expression is governed by the Imd pathway." FBgn0283467 FlyBase Gene Snapshot "DNA polymerase delta subunit 3 (PolD3) encodes a non-essential subunit of the multi-subunit DNA polymerases delta and zeta. It has roles during embryonic DNA replication and promotes several types of DNA repair, including homologous recombination repair of double-strand breaks." FBgn0283468 FlyBase Gene Snapshot "supernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2." FBgn0283469 FlyBase Gene Snapshot "Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division." FBgn0283471 FlyBase Gene Snapshot "wings up A (wupA) encodes a cytoskeletal protein of the troponin complex of the muscle thin filament. It is involved in calcium-dependent regulation of muscle contraction, and in development of the embryonic heart, skeletal muscle and flight muscle It also contributes to non-muscle functions such as apico-basal polarity formation, nuclear division and maintenance of nuclear integrity." FBgn0283472 FlyBase Gene Snapshot "Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size." FBgn0283473 FlyBase Gene Snapshot S6 Kinase Like (S6KL) encodes a serine/threonine kinase that inhibits BMP signaling through facilitating degradation of the BMP receptor encoded by tkv. It inhibits neuromuscular junction growth and promotes synaptic endocytosis at the neuromuscular junctions. FBgn0283476 Alliance Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility. Is active in sperm flagellum. Is expressed in chordotonal neurons; spermatogonium; spermatozoon; and testis. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). FBgn0283477 FlyBase Gene Snapshot "Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism." FBgn0283478 FlyBase Gene Snapshot "uninitiated (und) encodes encodes a predicted metalloexopeptidase, which contributes to omatidial polarity and tissue growth control." FBgn0283479 FlyBase Gene Snapshot Alkaline phosphatase 1 (Alp1) encodes an alkaline phosphatase. Alkaline phosphatases catalyze the hydrolysis of monoesters of phosphoric acid and a transphosphorylation reaction in the presence of large concentrations of phosphate acceptors. FBgn0283480 Alliance "Enables alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental)." FBgn0283494 UniProtKB Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (UniProtKB:Q9U915) FBgn0283499 UniProtKB "Has a ligand-stimulated tyrosine-protein kinase activity (PubMed:7628438, PubMed:8603594). Regulates cell number and cell size during development by regulating cell growth and survival, affecting body size and organ size, including ovaries and imaginal disks (PubMed:10455177, PubMed:11250149, PubMed:8603594). Plays a role in life-span determination (PubMed:11292875). May be involved in regulation of other neuroendocrine signaling pathways (PubMed:11292875). Involved in the development of the embryonic nervous system (PubMed:7628438). Functions upstream of dock/dreadlocks for photoreceptor (R cell) axon guidance and targeting in the visual system (PubMed:12702880). (UniProtKB:P09208)" FBgn0283500 FlyBase Gene Snapshot "Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance." FBgn0283503 Alliance Predicted to enable ubiquitin protein ligase activity. Located in centrosome. Orthologous to human NEURL4 (neuralized E3 ubiquitin protein ligase 4). FBgn0283508 Alliance "Predicted to enable carbohydrate binding activity. Involved in regulation of imaginal disc-derived wing size. Located in extracellular space. Is expressed in several structures, including clypeo-labral primordium; embryonic head epidermis; epidermis; gut section; and sense organ." FBgn0283509 FlyBase Gene Snapshot "Peptidylglycine-alpha-hydroxylating monooxygenase (Phm) encodes a hydroxylating monooxygenase, dedicated to the regulated secretory pathway and critical for proper neuropeptide biosynthesis. It promotes the potency and stability of secreted neuropeptides via C-terminal amidation." FBgn0283510 FlyBase Gene Snapshot Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1 (Pal1) encodes a peptidylamidoglycolate lyase that regulates adult wing size. FBgn0283521 FlyBase Gene Snapshot "longitudinals lacking (lola) encodes a protein involved in Notch signaling, cell death, regulation of retrotransposons and expression of axon and dendrite patterning genes. It contributes to oogenesis, spermatogenesis, neural wiring, eye development and a variety of behaviors." FBgn0283525 Alliance Predicted to enable rRNA methyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). FBgn0283531 UniProtKB "Plays a role in innate immunity limiting microbial proliferation in the gut (PubMed:16272120, PubMed:25639794). Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). May generate antimicrobial oxidative burst through its peroxidase-like domain (PubMed:16272120). (UniProtKB:Q9VQH2)" FBgn0283535 FlyBase Gene Snapshot Vacuolar H[+]-ATPase 26kD subunit (Vha26) encodes the E subunit of the V1 domain of the vacuolar ATPase that is required for the morphology of tracheal cells. FBgn0283536 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334). (UniProtKB:Q9XZH6)" FBgn0283545 FlyBase Gene Snapshot vilya (vilya) encodes a meiosis-specific ring-domain-containing protein that is required for programmed meiotic double-strand break formation. It also functions as a component of the recombination nodule. FBgn0283649 FlyBase Gene Snapshot early girl (elgi) encodes a myosin binding protein involved in the regulation of meiosis and Fat signaling pathway. FBgn0283651 Alliance Predicted to be located in nucleoplasm. Orthologous to several human genes including NOL4 (nucleolar protein 4). FBgn0283652 FlyBase Gene Snapshot RNaseP protein p30 (Rpp30) encodes a protein involved in tRNA processing. FBgn0283657 FlyBase Gene Snapshot "Tousled-like kinase (Tlk) encodes a serine/threonine kinase that acts in a cell cycle-dependent manner. It contributes to cell morphogenesis, cell migration and cell death through interactions with chromatin components." FBgn0283658 Alliance Predicted to enable dihydrolipoyllysine-residue acetyltransferase activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in grooming behavior. Predicted to be located in mitochondrion. Predicted to be part of pyruvate dehydrogenase complex. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). FBgn0283659 UniProtKB Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (UniProtKB:Q9V3N8) FBgn0283666 Alliance "Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in germ-line stem cell population maintenance. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Orthologous to several human genes including RAP2C (RAP2C, member of RAS oncogene family)." FBgn0283678 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0283680 FlyBase Gene Snapshot "Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling." FBgn0283681 UniProtKB "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (UniProtKB:Q9VV41)" FBgn0283682 UniProtKB "In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets. (UniProtKB:Q9VKK1)" FBgn0283685 Alliance Involved in germ-band extension. FBgn0283712 FlyBase Gene Snapshot LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. FBgn0283724 Interactive Fly scaffolding protein - regulates cell polarity - supports the activity of Yrt and Lgl by restricting the activity of aPKC - essential for sensory dendrite formation - regulates the formation of actin structures that may temporarily stabilize the dendritic tip and is essential for its connection to the dendritic sheath - a positive regulator of adherens junction function - stabilizes epithelial cell adhesion and promotes morphogenesis by regulating the linkage of the cadherin-catenin complex to the actin cytoskeleton - involved in Akt pathway control of cell size FBgn0283728 Alliance Predicted to be located in membrane. FBgn0283741 FlyBase Gene Snapshot prage (prage) encodes a protein involved in maternal mRNA destabilization during the maternal/zygotic transition in embryonic development. FBgn0284084 FlyBase Gene Snapshot "wingless (wg) is a segment polarity gene that encodes a ligand of the Wnt/Wg signaling pathway. Its post-translational modification (addition of palmitoleate by the product of por) is essential for signaling activity. It contributes to segment polarity, tissue growth and patterning, neuromuscular junction morphogenesis, gut homeostasis and long term memory formation." FBgn0284220 FlyBase Gene Snapshot "Topoisomerase 2 (Top2) encodes an enzyme that alters the topology of DNA by creating a transient DNA double strand breakage. It is essential for removing supercoils generated via DNA replication and transcription, and decatenating replicated sister chromosomes during cell division." FBgn0284221 FlyBase Gene Snapshot "Semaphorin 5c (Sema5c) encodes a member of the Semaphorins family, which are membrane and secreted short-range signaling proteins. The product of Sema5c is involved in olfactory behavior." FBgn0284243 UniProtKB "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. (UniProtKB:Q24560)" FBgn0284244 Alliance Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. FBgn0284245 UniProtKB This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. (UniProtKB:P08736) FBgn0284246 Alliance "Involved in muscle cell cellular homeostasis. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human WDR74 (WD repeat domain 74)." FBgn0284247 UniProtKB "Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:26073018, PubMed:7601355). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018). (UniProtKB:Q24292)" FBgn0284248 UniProtKB "Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (UniProtKB:P84029)" FBgn0284249 UniProtKB May play an important role not only in the regulation of Adh expression but also in the transcription of other genes. (UniProtKB:P05552) FBgn0284251 Alliance "Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; embryonic/larval muscle cell; and mesoderm. Orthologous to human WDR75 (WD repeat domain 75)." FBgn0284252 UniProtKB Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. (UniProtKB:P91927) FBgn0284253 Alliance Predicted to enable leucine-tRNA ligase activity. Involved in wound healing. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). FBgn0284254 Alliance Predicted to enable small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Is expressed in adult head; embryonic/larval hypodermal muscle cell; embryonic/larval neuromuscular junction; and organism. Orthologous to human IPO11 (importin 11). FBgn0284255 FlyBase Gene Snapshot "Actin-related protein 2/3 complex, subunit 4 (Arpc4) encodes a subunit of the actin-related protein 2/3 complex with roles in cortical actin cytoskeleton organization. It is involved in cell adhesion, regulation of cell shape and wound healing." FBgn0284256 FlyBase Gene Snapshot "bicoid stability factor (bsf) encodes a member of the family of proteins containing the pentatricopeptide motif, an RNA binding domain. It is found in the cytoplasm, where it functions in mRNA stability and post-transcriptional control of gene expression, and in mitochondria, where it has multiple roles in gene expression. It acts at many stages of development, and is required for progression through oogenesis and viability." FBgn0284257 FlyBase Gene Snapshot TRPL translocation defect 14 (Ttd14) encodes a cytosolic GTP binding protein that binds to the membrane lipids 3-phosphoinositide and phosphatic acid. It has a role in recycling of internalized membrane proteins like the ion channel encoded by trpl in photoreceptor cells. FBgn0284408 FlyBase Gene Snapshot "terribly reduced optic lobes (trol) encodes the extracellular matrix component Perlecan, a secreted heparan sulfate proteoglycan. It regulates cell-signaling by multiple growth factors including those in the hedgehog, wingless/WNT, FGF, TGFbeta, EGF, and VEGF families, thus playing a role in many developmental patterning decisions." FBgn0284409 Alliance Involved in spermatogenesis. FBgn0284410 Alliance Involved in spermatogenesis. FBgn0284411 Alliance Involved in spermatogenesis. FBgn0284419 Alliance Involved in spermatogenesis. FBgn0284420 Alliance Involved in spermatogenesis. FBgn0284421 UniProtKB "Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. (UniProtKB:O02194)" FBgn0284429 Alliance Involved in spermatogenesis. FBgn0284431 Alliance Involved in spermatogenesis. FBgn0284435 FlyBase Gene Snapshot trynity (tyn) encodes a protein belonging to the ZP-domain proteins family known as extracellular modular proteins. These proteins are secreted and anchored to the membrane or released into the extracellular space to form specialized extracellular matrices. FBgn0284436 Alliance "Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult brain cell body rind; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8)." FBgn0284442 FlyBase Gene Snapshot "Minichromosome maintenance 3 (Mcm3) encodes a component of the MCM2-7 hexamer, which forms part of the CMG complex, together with the product of CDC45L and GINS proteins. The CMG complex is the main DNA helicase that functions during DNA replication." FBgn0284444 Alliance "Involved in telomere capping. Located in chromosome, telomeric region. Is expressed in individualization stage spermatid; late elongation-stage spermatid; mid-late elongation-stage spermatid; and spermatozoon." FBgn0285879 FlyBase Gene Snapshot "disco-related (disco-r) encodes a C2H2 zinc-finger transcription factor. It has known roles in larval and adult appendage development, where it appears to control proximal-distal fate in ventral appendages including adult legs, antenna, and larval and adult mouthparts." FBgn0285892 UniProtKB "Part of the MTV complex that associates with the HipHop-HOAP complex to form the terminin telomere-capping complex involved in telomere maintenance and prevention of telomere fusion (PubMed:27835648). As part of the MTV complex binds single stranded DNA in a sequence-independent manner, protecting it from degradation (PubMed:27835648). May mediate recruitment of the MTV complex at telomeres through interaction with components of the HipHop-HOAP complex (PubMed:27835648). (UniProtKB:E1JH25)" FBgn0285896 FlyBase Gene Snapshot breathless (btl) encodes a Fibroblast Growth Factor (FGF) receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic tracheal migration. FBgn0285910 FlyBase Gene Snapshot "Vacuolar H[+] ATPase AC39 subunit 1 (VhaAC39-1) encodes a subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It is involved in endocytic trafficking, and VhaAC39-1 mutations block Notch signaling in follicle cells and imaginal disc cells." FBgn0285911 FlyBase Gene Snapshot "Vacuolar protein sorting 16A (Vps16A) encodes a subunit of a heterohexameric tethering complex known as homotypic fusion and protein sorting (HOPS). HOPS roles include promoting the fusion of late endosomes, autophagosomes, biosynthetic vesicles, and lysosomes, and the biogenesis of lysosome-related eye pigment granules. The product of Vps16A is also part of miniCORVET (class C core vacuole/endosome tethering), a tethering complex involved in endosome maturation in nephrocytes and blood cells." FBgn0285912 Alliance Predicted to enable gamma-aminobutyric acid:proton symporter activity. Predicted to be involved in gamma-aminobutyric acid transport. Is expressed in adult abdomen; adult head; and adult thorax. FBgn0285913 Alliance "Is expressed in several structures, including Malpighian tubule primordium; embryonic Malpighian tubule; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human LYSMD1 (LysM domain containing 1) and LYSMD2 (LysM domain containing 2)." FBgn0285917 FlyBase Gene Snapshot "scribbler (sbb) encodes a transcriptional co-regulator that acts mainly as a co-repressor. It interacts physically and genetically with the product of Gug and is used by the repressor encoded by tll in early embryos. It regulates larval behavior, photoreceptor axon target choice, and functions downstream of Hedgehog signaling." FBgn0285925 UniProtKB Neural cell adhesion molecule. (UniProtKB:P10674) FBgn0285926 FlyBase Gene Snapshot "IGF-II mRNA-binding protein (Imp) encodes a protein that regulates the stability, translation and/or transport of its associated mRNAs, a large number of them encoding F-actin regulators. It is an essential protein required for neural and germline stem cell maturation, neuronal remodeling, as well as the expression modulation of asymmetrically localized maternal mRNAs." FBgn0285937 FlyBase Gene Snapshot "Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis." FBgn0285943 Alliance "Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in Nebenkern assembly. Part of mitochondrial proton-transporting ATP synthase complex. Is expressed in adult head; primary spermatocyte; secondary spermatocyte; spermatid cyst; and spermatozoon. Orthologous to human ATP5PD (ATP synthase peripheral stalk subunit d)." FBgn0285944 FlyBase Gene Snapshot paralytic (para) is an essential gene required for locomotor activity. It encodes an alpha-subunit of voltage-gated sodium channels. It is required for generation of sodium-dependent action potentials. FBgn0285947 FlyBase Gene Snapshot Ribosomal protein S10b (RpS10b) encodes a structural constituent of ribosomes. FBgn0285948 FlyBase Gene Snapshot Ribosomal protein L27A (RpL27A) encodes a ribosomal structural constituent. FBgn0285949 Alliance A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Orthologous to human RPL31 (ribosomal protein L31). FBgn0285950 FlyBase Gene Snapshot Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent. FBgn0285951 Alliance Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 32. Orthologous to human MRPS34 (mitochondrial ribosomal protein S34). FBgn0285952 UniProtKB "Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Functions as a regulator of autophagy (PubMed:19546244). (UniProtKB:Q9GU68)" FBgn0285954 FlyBase Gene Snapshot "cabeza (caz) encodes a chromatin binding protein involved in locomotion, synaptic growth at the neuromuscular junction and eye development." FBgn0285955 FlyBase Gene Snapshot crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis. FBgn0285958 FlyBase Gene Snapshot "alpha-L-fucosidase (Fuca) encodes an enzyme belonging to the family of hydrolases. It has also been identified as a transmembrane protein in the plasma-membrane of spermatozoa. Its roles include N-glycan degradation, glycan structure degradation, and is potentially involved in fertilization, particularly in initial sperm-egg recognition." FBgn0285959 Alliance Involved in germ-line stem-cell niche homeostasis and lncRNA-mediated post-transcriptional gene silencing. Is expressed in organism; ovary; and unfertilized egg. FBgn0285963 Alliance "Enables aminopeptidase activity. Involved in several processes, including cell dedifferentiation; germ-line stem-cell niche homeostasis; and male germ-line stem cell population maintenance. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head." FBgn0285969 Alliance Located in cytosol. Is active in nucleus. FBgn0285970 UniProtKB Molecular scaffold for (UniProtKB:Q8SY96) FBgn0285971 FlyBase Gene Snapshot piragua (prg) encodes a transcription factor that interacts genetically with fwe. It is required for embryonic dorsal closure and head involution as well as thorax and eye imaginal development. FBgn0285975 Alliance Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of G1/S transition of mitotic cell cycle. FBgn0285976 Alliance Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of G1/S transition of mitotic cell cycle. FBgn0286006 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in organism. FBgn0286007 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Is expressed in organism. FBgn0286027 UniProtKB mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). (UniProtKB:Q9VJQ4) FBgn0286051 Alliance Enables 3'-5'-RNA exonuclease activity. Involved in rRNA 3'-end processing and sno(s)RNA 3'-end processing. Located in nucleolus. Orthologous to human REXO5 (RNA exonuclease 5). FBgn0286070 Interactive Fly signaling protein - a critical molecule functioning downstream of Alk - mutational loss genocopies the lack of visceral muscle founder cell specification of Alk and jeb mutants - interacts with Steppke as part of a larger signaling scaffold coordinating receptor tyrosine kinase-dependent MAPK activation FBgn0286071 FlyBase Gene Snapshot ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. FBgn0286075 FlyBase Gene Snapshot DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. FBgn0286198 FlyBase Gene Snapshot "Lysine ketoglutarate reductase/saccharopine dehydrogenase (LKRSDH) encodes a bifunctional enzyme that catalyzes the first two steps in the lysine degradation pathway. Independently of its enzymatic activity, it also acts as a transcriptional corepressor in ecdysone signaling." FBgn0286199 Alliance Predicted to enable monoamine oxidase activity. Is expressed in organism. FBgn0286203 Alliance Predicted to enable catechol oxidase activity and tyrosinase activity. Involved in chitin-based cuticle development. Predicted to be active in plasma membrane. Is expressed in adult head. FBgn0286204 UniProtKB "Transcriptional activator. In tracheal terminal cells, regulates the transcription of factors involved in the formation of a mature apical extracellular matrix (aECM) which is essential for the integrity and shape of seamless tubes. (UniProtKB:Q9VHJ6)" FBgn0286213 FlyBase Gene Snapshot Ribosomal protein S12 (RpS12) is an essential gene encoding a protein component of the cytoplasmic small ribosomal subunit. FBgn0286222 Alliance "Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; epithelium; and germline cell. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase)." FBgn0286506 FlyBase Gene Snapshot "Mannose phosphate isomerase (Mpi) encodes a putative enzyme that is predicted to catalyze the interconversion of fructose 6-phosphate and mannose 6-phosphate, and thus may be involved in mannose metabolism." FBgn0286507 Alliance Involved in chromatin organization. Part of chromatin. FBgn0286508 FlyBase Gene Snapshot beta Hydroxy acid dehydrogenase 1 (Had1) encodes an enzyme that catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate and is predicted to be involved in the catabolism of D-glucuronate into D-xylulose 5-phosphate. FBgn0286511 Alliance "Enables phospholipase D activity. Involved in several processes, including gastrulation involving germ band extension; phototransduction; and positive regulation of Golgi vesicle fusion to target membrane. Located in cytoplasmic vesicle. Is expressed in several structures, including adult head; embryonic anal pad; embryonic epipharynx; embryonic hypopharynx; and embryonic large intestine. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1) and PLD2 (phospholipase D2)." FBgn0286516 Alliance Predicted to be active in nucleus. Orthologous to human PNRC1 (proline rich nuclear receptor coactivator 1) and PNRC2 (proline rich nuclear receptor coactivator 2). FBgn0286517 Alliance Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of G1/S transition of mitotic cell cycle. FBgn0286518 Alliance Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of G1/S transition of mitotic cell cycle. FBgn0286519 Alliance Involved in positive regulation of G1/S transition of mitotic cell cycle. FBgn0286567 FlyBase Gene Snapshot gryzun (gry) encodes a protein required for secretion that localizes to the early Golgi apparatus. It has been implicated in memory formation. FBgn0286723 UniProtKB "Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:26893370, PubMed:29739804). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104). (UniProtKB:Q9V3U0)" FBgn0286728 FlyBase Gene Snapshot C/D box small nucleolar RNA 69 (snoRNA:CD69) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0286729 FlyBase Gene Snapshot C/D box small nucleolar RNA 70 (snoRNA:CD70) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0286730 FlyBase Gene Snapshot C/D box small nucleolar RNA 71 (snoRNA:CD71) is predicted to encode a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation in rRNA. FBgn0286732 FlyBase Gene Snapshot C/D box small nucleolar RNA 72 (snoRNA:CD72) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3412 in 28SrRNA:CR45844. FBgn0286733 FlyBase Gene Snapshot C/D box small nucleolar RNA 73 (snoRNA:CD73) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C3412 in 28SrRNA:CR45844. FBgn0286734 FlyBase Gene Snapshot C/D box small nucleolar RNA 74 (snoRNA:CD74) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of C2716 in 28SrRNA:CR45844. FBgn0286737 FlyBase Gene Snapshot C/D box small nucleolar RNA 75 (snoRNA:CD75) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0286739 FlyBase Gene Snapshot C/D box small nucleolar RNA 76 (snoRNA:CD76) is predicted to encode a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation in rRNA. FBgn0286740 FlyBase Gene Snapshot C/D box small nucleolar RNA 77 (snoRNA:CD77) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of an unknown target. FBgn0286741 Alliance Predicted to enable metal ion binding activity. FBgn0286758 FlyBase Gene Snapshot C/D box small nucleolar RNA 39c (snoRNA:CD39c) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of U1357 and G1359 in 18SrRNA:CR45838. FBgn0286778 Alliance "Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization. Located in cytosol and nucleoplasm. Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; embryonic/larval garland cell; embryonic/larval salivary gland; and epithelium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. Orthologous to several human genes including TENT5A (terminal nucleotidyltransferase 5A); TENT5B (terminal nucleotidyltransferase 5B); and TENT5C (terminal nucleotidyltransferase 5C)." FBgn0286781 UniProtKB Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis. (UniProtKB:Q9V431) FBgn0286782 UniProtKB "Probable endopeptidase. In tracheal terminal cells, acts downstream of ich to regulate seamless tube growth and/or maintenance probably by processing lumenal matrix proteins. (UniProtKB:B7YZU2)" FBgn0286783 FlyBase Gene Snapshot Electron transfer flavoprotein-ubiquinone oxidoreductase (Etf-QO) encodes a mitochondrial membrane bound protein that acts as a hub with the product of wal and fuels electrons from fatty acid oxidation by matrix dehydrogenases into the respiratory chain. FBgn0286784 FlyBase Gene Snapshot "Transitional endoplasmic reticulum 94 (TER94) encodes a protein that operates as a hexamere, functioning as a ubiquitin-dependent molecular chaperone. The hexamere associates with different co-factors to process nuclear and cytoplasmic substrates marked by ubiquitin." FBgn0286785 FlyBase Gene Snapshot "scab (scb) encodes the alpha-PS3 Integrin, believed to dimerise with mys and possibly Itgbn. It regulates adhesion, signalling, polarity and cell migration. Genetic interaction with Laminin genes implicates them as extracellular matrix ligands." FBgn0286786 UniProtKB Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity). (UniProtKB:Q9U3Z7) FBgn0286788 FlyBase Gene Snapshot "Origin recognition complex subunit 1 (Orc1) encodes the largest subunit of the origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells. The ATPase activity of the product of Orc1 is critical for the formation and function of the pre-replicative complex. The regulated degradation of the product of Orc1 by ubiquitin-mediated proteolysis after initiation of DNA replication helps to prevent re-replication." FBgn0286809 FlyBase Gene Snapshot "xmas (xmas) encodes encodes a hydrophilic protein that is involved in spermatogenesis, oogenesis and embryogenesis." FBgn0286813 FlyBase Gene Snapshot SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. FBgn0286818 UniProtKB Participates in the folding of proteins containing disulfide bonds. (UniProtKB:P54399) FBgn0286827 Alliance Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. FBgn0286828 Alliance "Involved in chromosome organization. Located in cytosol and nucleoplasm. Part of chromatin. Is expressed in several structures, including adult head; anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm." FBgn0286852 Alliance "Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain; ganglia; and glial cell." FBgn0286868 Alliance Acts upstream of with a negative effect on chaeta development. Is expressed in adult abdomen and adult head. FBgn0286878 Alliance Involved in DNA replication initiation. FBgn0286898 FlyBase Gene Snapshot "Transport and Golgi organization 1 (Tango1) is the only Drosophila member of the MIA/cTAGE (melanoma inhibitory activity/cutaneous T cell lymphoma-associated antigen) gene family. It encodes a transmembrane protein required for correct ER exit site (ERES) morphogenesis and general secretion. The Tango1 product maintains ERES size and ERES-Golgi connection through self-interaction and interactions with Sec23, Rab1 and cis-Golgi proteins." FBgn0286930 Alliance Predicted to be involved in gamma-tubulin complex localization. Predicted to be part of gamma-tubulin ring complex. FBgn0286976 Alliance Predicted to be located in plasma membrane. Predicted to be active in membrane. FBgn0286977 Alliance Predicted to be active in membrane. FBgn0286979 Alliance Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase). FBgn0286980 UniProtKB "Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:27643701). Activity towards 3-fluoro-L-tyrosine is weak (PubMed:27643701). Important for male and female fertility (PubMed:29764939). May be involved in maintaining the viability of sperm, both during development in the testes and storage in the female spermatheca (PubMed:29764939). (UniProtKB:E1JIB2)" FBgn0287182 Alliance Predicted to enable protein kinase regulator activity. Predicted to be involved in cellular response to amino acid starvation and regulation of translation. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). FBgn0287183 Alliance Is expressed in adult head. Orthologous to human DNAJC16 (DnaJ heat shock protein family (Hsp40) member C16). FBgn0287184 Alliance Predicted to enable [acyl-carrier-protein] S-acetyltransferase activity and fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in adult head; adult heart; adult oenocyte; and spermatozoon. Orthologous to human FASN (fatty acid synthase). FBgn0287185 FlyBase Gene Snapshot neverland (nvd) encodes an evolutionarily conserved oxygenase-like protein that is required for the biosynthesis pathway of ecdysone. It converts cholesterol to 7-dehydrocholesterol. FBgn0287186 FlyBase Gene Snapshot "scarecrow (scro) is an NK-2 homeobox gene that is expressed in specific neuronal clusters of the ventral nerve cord and in the optic lobes of the brain, as well as in the developing pharynx." FBgn0287187 Alliance "Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; embryonic/larval muscle cell; and gut section. Orthologous to human MRPS5 (mitochondrial ribosomal protein S5)." FBgn0287204 UniProtKB Required for normal Golgi function. (UniProtKB:Q9VKH0) FBgn0287209 FlyBase Gene Snapshot "Glutamine:fructose-6-phosphate aminotransferase 1 (Gfat1) encodes an enzyme that catalyzes the transamination of fructose 6-phosphate to D-glucosamine 6-phosphate. It is involved in the biosynthesis of UDP-N-acetylglucosamine, a precursor for chitin biosynthesis and protein glycosylation." FBgn0287225 UniProtKB Required to maintain the proper number of mitochondria in neurons and muscles. (UniProtKB:Q9VEX6) FBgn0287234 FlyBase Gene Snapshot schlaff (slf) encodes a chitin binding protein involved in wing formation and the substrate for the product of Tg. FBgn0287423 Alliance "Involved in humoral immune response. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative." FBgn0287454 Alliance Part of MLL3/4 complex. Is expressed in organism. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). FBgn0287461 Alliance Is expressed in midgut primordium and proctodeum. FBgn0287462 Alliance Is expressed in ectoderm and organism. FBgn0287463 Alliance Is expressed in organism. FBgn0287464 Alliance Is expressed in embryonic/larval gut and mesoderm. FBgn0287478 FlyBase Gene Snapshot "Calmodulin-binding transcription activator (Camta) encodes a Ca[2+]-responsive transcription factor that either binds directly to DNA sequences containing a CGCG core motif or functions as a coactivator of NKX2 transcription factors. It mediates various physiological functions, including the regulation of visual signal transduction, memory formation and cell survival." FBgn0287585 UniProtKB Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine. (UniProtKB:Q9VPD3) FBgn0287589 Alliance Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Orthologous to human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2). FBgn0287597 Alliance Orthologous to human C1orf198 (chromosome 1 open reading frame 198). FBgn0287600 Alliance Is expressed in embryonic head; mesoderm; and midgut primordium. FBgn0287601 Alliance Is expressed in embryonic/larval gut; mesoderm; and organism. FBgn0287602 Alliance Is expressed in organism. FBgn0287603 Alliance Is expressed in organism. FBgn0287604 Alliance Is expressed in embryonic head and mesoderm. FBgn0287605 Alliance Is expressed in organism. FBgn0287630 Alliance Predicted to enable nucleic acid binding activity and zinc ion binding activity. Is expressed in gonad and testis. Orthologous to human ZMAT3 (zinc finger matrin-type 3); ZMAT4 (zinc finger matrin-type 4); and ZNF346 (zinc finger protein 346). FBgn0287631 Alliance Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Is expressed in leg and spermatozoon. FBgn0287633 Alliance Involved in positive regulation of antimicrobial humoral response. Is active in nucleus. FBgn0287645 Alliance Involved in behavioral response to ethanol and central complex development. Is expressed in DALv2 lineage neurons; embryonic Malpighian tubule; embryonic/larval salivary gland; embryonic/larval tracheal system; and synaptic neuropil domain. Used to study alcohol use disorder. FBgn0287695 UniProtKB "Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites. (UniProtKB:Q9VMC9)" FBgn0287696 Alliance Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. FBgn0287720 FlyBase Gene Snapshot "Pendulin (Pen) encodes a member of the Importin-alpha protein family, an essential adaptor in the Ran-GTP nuclear transport cycle binding a cargo protein to the nuclear import receptor encoded by Fs(2)Ket. In addition to nuclear protein import, the product of Pen is involved in centrosome duplication, mitotic spindle dynamics, nuclear envelope assembly, ring canal formation in the female germline, geotaxic behaviour and perception of pain." FBgn0287724 Alliance Enables voltage-gated calcium channel activity. Involved in calcium ion transmembrane transport; calcium-mediated signaling; and neuron remodeling. Predicted to be part of voltage-gated calcium channel complex. Is expressed in adult head. FBgn0287725 Alliance "Involved in piRNA-mediated retrotransposon silencing by heterochromatin formation. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; germarium region 1; germline cell; and somatic cell of ovariole." FBgn0287767 Alliance "Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol and nucleus. Is expressed in several structures, including adult head; embryonic/larval brain; embryonic/larval crystal cell; embryonic/larval midgut primordium; and gut section." FBgn0287768 FlyBase Gene Snapshot "escargot (esg) encodes a Snail-type transcription factor that contributes to stem cell maintenance, tracheal morphogenesis and neuroblast differentiation." FBgn0287774 Alliance "Predicted to enable RNA helicase activity. Predicted to be active in nucleolus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm." FBgn0287775 FlyBase Gene Snapshot "18 wheeler (18w) encodes a member of the Toll-like receptor family. It contributes to multiple processes including ovarian follicle cell migration, antibacterial humoral response and ventral cord development. A role in convergent extension during early embryogenesis is suggested by the genetic interaction of 18w with Toll-6 and Tollo." FBgn0287788 Alliance Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process and ATP biosynthetic process. Is expressed in adult head and oocyte. FBgn0287825 UniProtKB "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334). (UniProtKB:Q9V7N5)" FBgn0287828 Alliance Predicted to enable ATP binding activity and diacylglycerol-dependent serine/threonine kinase activity. Involved in flight. Predicted to be located in plasma membrane. Is expressed in adult brain. FBgn0287831 UniProtKB "Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine (PubMed:25406072, PubMed:7498465, PubMed:8901578). In astrocytes, regulates sleep homeostasis by limiting the accumulation of serotonin and dopamine in the brain upon sleep deprivation (PubMed:10710313, PubMed:32955431). Is not essential for sclerotization (PubMed:9703021). (UniProtKB:Q94521)" FBgn0287844 Alliance Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sensory perception of sound. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in antenna; chordotonal neurons; and spermatozoon. Used to study sensorineural hearing loss. FBgn0287864 FlyBase Gene Snapshot hibris (hbs) encodes a Ig repeat transmembrane protein with a fibronectin type III domain. It functions as a receptor involved in muscle cell fusion. FBgn0287873 FlyBase Gene Snapshot "zipper (zip) encodes the sole nonmuscle myosin 2 heavy chain protein, which forms a complex with two obligate binding partners, encoded by the nonmuscle myosin essential light chain, Mlc-c, and the nonmuscle myosin regulatory light chain, sqh. The myosin holoenzyme has motor activity that tethers to, and can translocate on, actin filaments. Both motor activity (a filamentous-actin-activated ATPase) and formation of bipolar filaments of the Zipper/light chain complex are regulated by phosphorylation of sqh by kinases, including those encoded by Rok, gek and Strn-Mlck. zip function is required for regulating cortical stiffness and cell shape changes during cytokinesis and morphogenesis." FBgn0288229 Alliance "Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland body; extraembryonic structure; and yolk nucleus." FBgn0288232 UniProtKB May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProtKB:Q9V774) FBgn0288310 FlyBase Gene Snapshot mauve (mv) encodes a member of the family of beige and Chediak-Higashi syndrome (BEACH)-domain containing proteins. Proteins in this family function to restrain the size of lysosomes and lysosome-related organelles. FBgn0288433 UniProtKB Probable transcription factor that can both act as an activator or a repressor depending on the context (By similarity). Involved in posterior spiracle development. Acts downstream of ems and cut in posterior spiracle development. (UniProtKB:A1Z9R4) FBgn0288447 FlyBase Gene Snapshot "Baramicin A2 (BaraA2), like its identical paralog BaraA1, encodes a polypeptide precursor that is cleaved at furin cleavage sites to give rise to antifungal peptides, and is regulated by the Toll signalling pathway. BaraA2 mutants are susceptible to fungal and Gram-positive bacterial infections and also show deficient recovery after neurotoxin injection." FBgn0288469 UniProtKB Involved in peroxisome biogenesis. (UniProtKB:Q9VWB0) FBgn0288470 Alliance Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be part of mRNA cleavage factor complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. FBgn0288631 Alliance Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and positive regulation of synapse pruning. Located in cis-Golgi network and endoplasmic reticulum exit site. Is expressed in adult head. FBgn0288686 UniProtKB "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. (UniProtKB:P08841)" FBgn0288690 Alliance Predicted to enable 5'-3' DNA helicase activity and 5'-flap endonuclease activity. Is expressed in organism and spermatozoon. FBgn0288700 FlyBase Gene Snapshot stargazin-like protein (stg1) encodes a channel regulator that modulates both AMPA receptor activity and glutamatergic synaptic transmission. FBgn0288833 FlyBase Gene Snapshot Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. FBgn0288834 Alliance "Predicted to enable DNA binding activity. Predicted to be involved in DNA recombination; DNA repair; and DNA replication. Predicted to be located in nucleus. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium." FBgn0288835 Alliance Involved in sperm competition. Located in cytosol and nucleus. FBgn0288846 FlyBase Gene Snapshot "uncoordinated 45 (unc-45) encodes a protein that binds the product of Hsp83 and myosin, and may may serve as a scaffold for their interaction. It is required for normal myosin accumulation and appears to play a role in myosin folding and/or protection from stress." FBgn0288856 UniProtKB "Required for efficient DNA replication, probably through involvement in telomere replication (PubMed:26110638). May have a role in telomere capping of heterochromatic chromosome ends (PubMed:26110638). (UniProtKB:Q7K4V4)" FBgn0288857 FlyBase Gene Snapshot "Yippee (Ype) encodes a predicted member of the E3 ubiquitin ligase complex. It has roles in adult cuticle pigmentation, wing morphology, bristle formation, developmental rate, and adult emergence." FBgn0288875 FlyBase Gene Snapshot Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction. FBgn0288888 FlyBase Gene Snapshot "taxi (tx) encodes a transcription factor that affects cell adhesion by regulating the expression of mys. It is involved in the development of multiple organs and cell-types including tendon cells, chordotonal organs and the wing." FBgn0288966 FlyBase Gene Snapshot "Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain." FBgn0288967 Alliance Predicted to enable microtubule severing ATPase activity. FBgn0288976 UniProtKB "Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. (UniProtKB:Q8INF7)" FBgn0289108 UniProtKB "Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (By similarity). Plays an important role in a RNA repair and splicing pathway which controls axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury, by activating splicing of Xbp1 to promote axon regeneration in response to axotomy (PubMed:25961792). (UniProtKB:Q9VD92)" FBgn0289122 FlyBase Gene Snapshot INO80 complex subunit (Ino80) encodes a component of the INO80 chromatin remodelling complex that interacts with Polycomb and Trithorax group proteins. It is involved in the regulation of homeotic gene expression and regression of ecdysone dependent transcription. FBgn0289323 UniProtKB "Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). (UniProtKB:A1ZAK1)" FBgn0289556 Alliance "Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces and cell-cell adhesion. Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; embryonic/larval midgut cell; gut section; and somatic precursor cell." FBgn0289578 Alliance "Predicted to enable 2 iron, 2 sulfur cluster binding activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Is expressed in several structures, including adult fat body; adult head; adult heart; embryonic/larval midgut primordium; and gut section." FBgn0289579 Alliance "Predicted to enable dihydrolipoyl dehydrogenase activity. Predicted to be involved in glycine catabolic process. Predicted to be part of glycine cleavage complex and pyruvate dehydrogenase complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval muscle cell; gut section; and visceral muscle primordium." FBgn0289650 FlyBase Gene Snapshot jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction. FBgn0289678 FlyBase Gene Snapshot paternal loss (pal) encodes a male-germline specific protein which localizes to spermatid nuclei during the histone-to-protamine transition. pal protein is required for the eviction of H3 and H4 histones after the removal of H2A and H2B during spermiogenesis. FBgn0289712 FlyBase Gene Snapshot "capping protein alpha (cpa) encodes an actin-binding protein that, along with the product of cpb, binds to the fast growing ends of actin filaments to restrict the addition or loss of actin monomers. It limits the nuclear translocation of the Hippo pathway mediator encoded by yki and restricts JNK signaling. It maintains epithelial integrity and controls the balance between proliferation and apoptosis in the wing imaginal disc. It plays important roles during oogenesis, as well as maintaining neuronal homeostasis." FBgn0289743 UniProtKB Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones. (UniProtKB:P33270) FBgn0289744 FlyBase Gene Snapshot "Endonuclease G (EndoG) encodes an enzyme with endodeoxyribonuclease and endoribonuclease activity. It is involved in germ cell programmed cell death, mitochondrion inheritance and spermatid development." FBgn0289745 Alliance "Enables serine hydrolase activity. Is expressed in several structures, including embryonic head epidermis; embryonic precursor of adult foregut; epidermis; gland; and gut section." FBgn0289868 FlyBase Gene Snapshot Odorant receptor 67c (Or67c) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. FBgn0289933 FlyBase Gene Snapshot "LanB1 (LanB1) encodes a subunit of laminin, a heterotrimeric protein found in the extracellular matrix (ECM) and a major component of the basal lamina. Laminins interact with a variety of cell surface molecules such as integrin receptors and other secreted ECM components. It contributes to ECM organization, tissue adhesion, cell motility and developmental patterning." FBgn0289994 FlyBase Gene Snapshot "Heat shock protein 27 (Hsp27) encodes a member of the ATP-independent, small heat shock protein family. It contributes to regulation of eye morphology, polyglutamine toxicity, lifespan and starvation tolerance."